Academic literature on the topic 'Cell assembly process'
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Journal articles on the topic "Cell assembly process"
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Sivia, Sebenova, Katarina Krajcova, and Velisek Karol. "Sensors in the Subsystems of Intelligent Assembly Cell." Applied Mechanics and Materials 220-223 (November 2012): 1825–28. http://dx.doi.org/10.4028/www.scientific.net/amm.220-223.1825.
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Intelligent assembly cell conception includes new solution kind of how to create structures of automated and flexible assembly system. Intelligent behavior of the system as the control system will repose on monitoring of important parameters of the system in the real time. The designed automation sensory equipment provides for automatic monitoring of all automated equipment motions in the first case and in the second important level is important to obtain the information about the status, presence and character of the assembled objects or assembly process. The application of the sensory equipment in the intelligent assembly process is designed on the ground of the sensory object properties of the pneumatic actuator model.
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Mao, Yong, and Jean E. Schwarzbauer. "Fibronectin fibrillogenesis, a cell-mediated matrix assembly process." Matrix Biology 24, no. 6 (2005): 389–99. http://dx.doi.org/10.1016/j.matbio.2005.06.008.
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Palm, R. "Interaction Process Models in a Robotized Assembly Cell." IFAC Proceedings Volumes 22, no. 10 (1989): 385–90. http://dx.doi.org/10.1016/s1474-6670(17)53204-8.
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Rónai, László, and Tamás Szabó. "Stability Analysis of an Assembly Process Using Simulation." Acta Technica Jaurinensis 13, no. 1 (2020): 14–24. http://dx.doi.org/10.14513/actatechjaur.v13.n1.531.
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This paper deals with an assembly process of batteries with cell holder. The operation involves snap-fitting phenomenon, which is a mechanical stability problem. The structure of the cell holder is modelled with 2D flexible beam elements assuming large displacements. The stability of the equilibrium is investigated taking into consideration non-frictional and Coulomb frictional contacts. The goal of the analysis to determine the boundary point of the feed-motion from which the battery snaps-in to the final assembled position autonomously. The effect of the velocity of the battery feed-motion is also considered with energy approach.
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Ružarovský, Roman, Nina Danišová, and Karol Velíšek. "Sensory System Design as an Implement for the Development of the Intelligent Assembly Cell." Advanced Materials Research 628 (December 2012): 287–91. http://dx.doi.org/10.4028/www.scientific.net/amr.628.287.
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Intelligent assembly cell conception includes new solution kind of how to create structures of automated and flexible assembly system. Intelligent behavior of the system as the control system will repose on monitoring of important parameters of the system in the real time. The designed automation sensory equipment provides for automatic monitoring of all automated equipment motions in the first case and in the second important level is important to obtain the information about the status, presence and character of the assembled objects or assembly process. The application of the sensory equipment in the intelligent assembly process is designed on the ground of the sensory object properties of the pneumatic actuator model. In the paper is described the sensor equipment application for the assembly part sorting situated before the input of the object into the assembly process and for the check function of assembly product is designed the combination of sensory equipment.
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Parker, Scott D., and Eric Hunter. "A Cell-Line-Specific Defect in the Intracellular Transport and Release of Assembled Retroviral Capsids." Journal of Virology 74, no. 2 (2000): 784–95. http://dx.doi.org/10.1128/jvi.74.2.784-795.2000.
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ABSTRACT Retrovirus assembly involves a complex series of events in which a large number of proteins must be targeted to a point on the plasma membrane where immature viruses bud from the cell. Gag polyproteins of most retroviruses assemble an immature capsid on the cytoplasmic side of the plasma membrane during the budding process (C-type assembly), but a few assemble immature capsids deep in the cytoplasm and are then transported to the plasma membrane (B- or D-type assembly), where they are enveloped. With both assembly phenotypes, Gag polyproteins must be transported to the site of viral budding in either a relatively unassembled form (C type) or a completely assembled form (B and D types). The molecular nature of this transport process and the host cell factors that are involved have remained obscure. During the development of a recombinant baculovirus/insect cell system for the expression of both C-type and D-type Gag polyproteins, we discovered an insect cell line (High Five) with two distinct defects that resulted in the reduced release of virus-like particles. The first of these was a pronounced defect in the transport of D-type but not C-type Gag polyproteins to the plasma membrane. High Five cells expressing wild-type Mason-Pfizer monkey virus (M-PMV) Gag precursors accumulate assembled immature capsids in large cytoplasmic aggregates similar to a transport-defective mutant (MA-A18V). In contrast, a larger fraction of the Gag molecules encoded by the M-PMV C-type morphogenesis mutant (MA-R55W) and those of human immunodeficiency virus were transported to the plasma membrane for assembly and budding of virions. When pulse-labeled Gag precursors from High Five cells were fractionated on velocity gradients, they sedimented more rapidly, indicating that they are sequestered in a higher-molecular-mass complex. Compared to Sf9 insect cells, the High Five cells also demonstrate a defect in the release of C-type virus particles. These findings support the hypothesis that host cell factors are important in the process of Gag transport and in the release of enveloped viral particles.
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Vetríková, Nina, and Michala Šimúnová. "Algorithms and Evolution Diagrams Application for Determining the New Assembly Process Sequences." Applied Mechanics and Materials 693 (December 2014): 16–21. http://dx.doi.org/10.4028/www.scientific.net/amm.693.16.
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In this contribution is presented application of evolution diagrams at the assembly process of at the intelligent manufacturing and assembly cell. At this assembly cell was designed new assembly configuration for next research to our department and institute. Intelligent manufacturing and assembly cell is situated at the Institute of Production Systems and Applied Mechanics. The complex design of assembly sequences at the intelligent manufacturing and assembly cell is realized on the basis of evolution diagrams and outgoing from knowledge about intelligent manufacturing and assembly systems. For intelligence increase of assembly process was this cell completed by additional sensors. This assembly process is possible to name intelligent assembly process.
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Koch, G. L., C. Booth, and F. B. Wooding. "Dissociation and re-assembly of the endoplasmic reticulum in live cells." Journal of Cell Science 91, no. 4 (1988): 511–22. http://dx.doi.org/10.1242/jcs.91.4.511.
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The endoplasmic reticulum (ER) of a typical interphase 3T3 fibroblast consists of a compact perinuclear arrangement of cisternae and lamellae which can be observed by immunofluorescence with anti-endoplasmin. During mitosis the reticulum dissociates into small fragments from which it appears to re-assemble in the daughter cells. When interphase 3T3 cells are exposed to calcium ionophores, but not other ionophores, there is a similar dissociation of the ER into small uniform fragments, which are dispersed throughout the cytoplasm. Electron microscopy shows that the fragments consist of small vesicular structures and that essentially all of the rough ER except the nuclear envelope is dissociated. The dissociation of the ER by calcium ionophore is a relatively specific process since other organelles and supramolecular assemblies remain unaffected. When cells with dissociated ER are returned to normal medium, there is a rapid reassembly of the fragments into the continuous reticulum. In a proportion of the cells it is possible to observe linear arrays of the fragments, which probably represent intermediates in the re-assembly process. These observations demonstrate that the ER in interphase 3T3 cells can be dissociated into, and re-assembled from, small fragments. Re-assembly of the ER from the fragments is dependent on the presence of millimolar levels of calcium in the external medium. In the presence of calcium, re-assembly is inhibited by the calcium channel blocker, verapamil. Thus calcium ions appear to play an important role in ER structure and assembly.
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Agnetis, A., R. Macchiaroli, and F. Nicolò. "Optimization of the Assembly Process in a Flexible Cell." IFAC Proceedings Volumes 29, no. 1 (1996): 613–18. http://dx.doi.org/10.1016/s1474-6670(17)57730-7.
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Liu, Hai Xia, Sheng Jie Li, Feng Lin, and Yong Nian Yan. "Modified Gelatin-Based Cell Assembling Process Using Glycerin." Advanced Materials Research 476-478 (February 2012): 443–47. http://dx.doi.org/10.4028/www.scientific.net/amr.476-478.443.
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Cell assembly technology adopting the gelatin-based composite materials has found broad application in the field of disease mechanism research, drug development and organ reconstruction etc. But there are still several troublesome problems, such as the necessaries of high forming concentration of gelatin-based materials and the cell damage produced during extrusion. In view of existing situation, a modified gelatin-based cell assembling process using glycerin was brought forward. The results showed that adding 10% (v/v) glycerin to the existing gelatin-based composite materials, the cells inactivation effect under 4 °C or lower temperature environment can be reduced obviously, meanwhile, the glycerin has a compensatory effect of gelatin. It can significantly improve the forming temperature and the cell survival rate, get high cell survival rate even when the scanning speed is on 40 mm/s. In addition, the glycerin is easier to dissolve in culture medium in the tissue analog training process; it is more conducive to the rapid materials degradation, as well as cell proliferation and tissue regeneration. Therefore, modified gelatin-based cell assembly process with glycerin will be more widely used in tissue or organ in vitro assembly process.
Dissertations / Theses on the topic "Cell assembly process"
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Millerd, Paul M. B. A. Massachusetts Institute of Technology. "Driving cycle time reduction through an improved material flow process in the electronics assembly manufacturing cell." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73395.
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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division; in conjunction with the Leaders for Global Operations Program at MIT, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 62).<br>Many companies have implemented lean and six sigma programs over the past twenty years. Lean has been a proven system that has eliminated waste and created value at many companies throughout the world. Raytheon IDS's lean program, "Raytheon Six Sigma" became a top priority in the past ten years at the Integrated Air Defense Center (IADC) in Andover, MA. However, as Raytheon's corporate goals state, they want to take this further and bring "Raytheon Six Sigma" to the next level, fully engaging customers and partners. A focus of this continuous improvement effort was the Electronics Assembly Rack manufacturing cell, which was experiencing high levels of cycle time variability. To help reduce cycle times within the cell, a continuous improvement project was undertaken to improve the material flow process. A current state analysis of the process showed an opportunity to improve process standardization and prioritization while lowering inventory levels. In addition to working with managers from EA to evaluate the material flow process, a kitting cart was developed with a cross functional project team to serve as a tool to help improve the process. Although the improvements were not rolled out to the entire cell during the project, a successful pilot was conducted that helped improve engagement with operators and create a path for future success.<br>by Paul Millerd.<br>S.M.<br>M.B.A.
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Lundström, Jonathan, and Emil Hörnberg. "Rotator assembly at Indexator." Thesis, Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-64058.
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The thesis is concerning rotator assembly at Indexator. A need to increase production has been seen and it can be done by implementing an optimized assembly process. In addition to the assembly process a new design on workstations and new test equipment is needed.The study resulted into three assembly process proposals. The processes were balanced, layouts were produced and Plant simulation was utilized to produce simulation models. Each proposal were analyzed based on cost, performance, ease of implementation, flexibility and worker condition. This resulted in a stationary assembly process being most promising and a 3D simulation model was produced for visualization and better understanding. The stationary assembly process has a capacity for 90 rotators per day, while reducing the amount of workers by one.The layout of the workstations was done based on the assembly process layout and further developed to make the work cell lean and ergonomic. It resulted in three workstations to perform the assembly. The test bench was developed by creating target specifications, establish a test procedure and decide components for the test bench layout. The finished test bench can measure dynamic torque, count particles to ensure cleanliness and is able to run the test unattended.<br>Examensarbetet handlar om montering av rotatorer på Indexator. Målet är att ta fram en optimerad monteringsprocess som kan implementeras i Indexators fabrik utan svårigheter. Den nya monteringsprocessen kommer kräva en ny design på arbetsstationerna och nya testbänkar.Fyra koncept på monteringsprocessen togs fram, baserat på monteringens behov och målsättning. Efter utvärdering så modifierades de fyra koncepten till tre förslag på monteringsprocesser. Processerna balancerades, layouter utvecklades och simuleringsmodeller producerades för varje process. Varje förslag analyserades baserat på kostnad, prestanda, implementation,flexibilitet och arbetar-förhållande. Resultatet blev en stationär monteringsprocess och en 3Dsimulering gjordes för visualisering och förståelse. Den stationära monteringsprocessen har en kapacitet på 90 rotatorer per dag och reducerar behovet av montörer.Layouten för monteringsstationerna baseras på processens layout och har modifierats för ergonomiska aspekter. Inom monteringsstationerna så utvecklades layouten för att minimera antalet onödiga rörelser för montören. Testriggens design utvecklades genom att analysera de behov som fanns, skapa en kravspecifikation samt utvärdera och besluta om testprocedur, upplägg för testrigg och dess ingående komponenter. Testriggen uppfyller målsättningen som är att kunna mäta dynamiskt vridmoment, räkna partiklar för att säkerställa renhet i rotatorn och kunna utföra testningen självgående för att frigöra montören under testprogrammet.
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Mostafaee, Mani. "Six Sigma for quality assurance of Lithium-ion batteries in the cell assembly process : A DMAIC field study at Northvolt." Thesis, Luleå tekniska universitet, Institutionen för ekonomi, teknik, konst och samhälle, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-85966.
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Lack of technical cleanliness and particle contaminations in Lithium-ion battery manufacturing affect the performance of batteries which are a risk for the safety and quality of the product. Therefore, part of the manufacturing process occurs inside the Clean and Dry room area to maintain technical cleanliness. This paper aims to provide a framework to control particle contamination inside the Clean and Dry room and strengthen the product's quality and safety. A literature study was conducted, which was completed by a field study at Northvolt Labs in Västerås to achieve the study's aims. The study contributes to existing theories by providing a framework to find root causes of particle contamination in the manufacturing process based on the existing literature and standards. The Six Sigma problem-solving methodology DMAIC was implemented to conduct the field study. A risk assessment was conducted to find the possible threats toward technical cleanliness in the cell assembly process. The risk sources were identified by implementing measurement methods from relevant standards. The results indicate a high risk for technical cleanliness are coming from the decontamination method, material, machines, and environment. Furthermore, several recommendations were given that are expected to decrease the amount of nonconformity in the process.<br>Brist på teknisk renhet och partikelföroreningar vid tillverkning av litiumjonbatterier påverkar dess prestanda och utgör en risk för produktens säkerhet och kvalitet. Därför sker en del av tillverkningsprocessen i ett Clean & Dry rum för att upprätthålla teknisk renhet. Denna uppsats syftar till att ge ett ramverk för att kontrollera partikelföroreningar och därmed stärka produktens kvalitet och säkerhet. För att uppnå syftet genomfördes först en litteraturstudie vilket vidare kompletterades med en fältstudie vid Northvolt Labs i Västerås. Studien bidrar till befintliga teorier genom att tillhandahålla ett ramverk för att hitta och åtgärda rotorsaker till partikelkontaminering i tillverkningsprocessen baserat på befintlig litteratur och standarder. Sex Sigma problemlösningsmetoden DMAIC implementerades för att genomföra fältstudien. En riskbedömning genomfördes för att hitta riskfyllda aktiviteter i processen. Vidare implementerades mätmetoder från relevanta standarder för att mäta kontamineringsnivån. Resultaten indikerar stor risk för tekniskrenhet från saneringsmetoder, material, maskiner och miljön. Vidare rekommenderas flera åtgärder för att underhålla tekniskrenhet vilka förväntas minska avvikelser i processen.
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von, Unwerth Thomas, and Welf-Guntram Drossel. "FC³ - 1st Fuel Cell Conference Chemnitz 2019 - Saubere Antriebe. Effizient Produziert.: Wissenschaftliche Beiträge und Präsentationen der ersten Brennstoffzellenkonferenz am 26. und 27. November 2019 in Chemnitz." Universitätsverlag Chemnitz, 2019. https://monarch.qucosa.de/id/qucosa%3A35720.
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Die erste Chemnitzer Brennstoffzellenkonferenz wurde vom Innovationscluster HZwo und dem Fraunhofer-Institut für Werkzeugmaschinen und Umformtechnik IWU durchgeführt. Ausgewählte Fachbeiträge und Präsentationen werden in Form eines Tagungsbandes veröffentlicht.<br>The first fuel cell conference was initiated by the innovation cluster HZwo and the Fraunhofer Institute for Machine Tools and Forming Technology. Selected lectures and presentations are published in the conference proceedings.
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Tse, Laam Angela. "Membrane Electrode Assembly (MEA) Design for Power Density Enhancement of Direct Methanol Fuel Cells (DMFCs)." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/11522.
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Micro-direct methanol fuel cells (micro-DMFC) can be the power supply solution for the next generation of handheld devices. The applications of the micro-DMFCs require them to have high compactness, high performance, light weight, and long life. The major goal of this research project is to enhance the volumetric power density of direct methanol fuel cells (DMFCs). A performance roadmap has been formulated and showed that patterning the planar membrane electrode assembly (MEA) to 2-D and 3-D corrugated manifolds can greatly increase the power generation with very modest overall volume increases. In this project, different manufacturing processes for patterning MEAs with corrugations have been investigated. A folding process was selected to form 2D triangular corrugations on MEAs for experimental validations of the performance prediction. The experimental results show that the volumetric power densities of the corrugated MEAs have improved by about 25% compared to the planar MEAs, which is lower than the expected performance enhancement. ABAQUS software was used to simulate the manufacturing process and identify the causes of deformations during manufacture. Experimental analysis methods like impedance analysis and 4 point-probes were used to quantify the performance loss and microstructure alteration during the forming process. A model was proposed to relate the expected performance of corrugated MEAs to manufacturing process variables. Finally, different stacking configurations and issues related to cell stacking for corrugated MEAs are also investigated.
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Siegel, Frank. "Tiefdruckverfahren zur Herstellung von Katalysatorschichten für (PEM) Brennstoffzellen." Doctoral thesis, Universitätsbibliothek Chemnitz, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-203816.
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Diese Dissertation befasst sich mit der industrienahen Herstellung von Katalysatorschichten für Polymer-Elektrolyt-Membran-Brennstoffzellen mit Hilfe des Tiefdrucks als Fertigungsverfahren. Um die Anforderungen an die Katalysatorschicht hinsichtlich der Schichtdicke zu erreichen, wird ein Linienraster für den Tiefdruck entwickelt. Das patentierte und verifizierte Designkonzept des Linienrasters ermöglicht es, trotz Tinten mit geringem Feststoffgehalt hohe Trockenschichtdicken zu erzeugen. Aufgrund des verwendeten Tiefdruckrasters sind Optimierungsschritte an der Fertigungsanlage notwendig, um eine hohe Schichtqualität zu erreichen. Schließlich werden kontinuierlich und industrienah Katalysatorschichten gefertigt, die als Membran-Elektroden-Einheit in einer Polymer-Elektrolyt-Membran-Brennstoffzelle erfolgreich eingesetzt werden<br>This work presents an industrial close manufacturing process of active electrodes for Polymer Electrolyte Fuel Cells utilizing an adapted gravure printing process. To meet the requirements of the electrodes regarding the layer thickness (weight) and quality a novel line screen with maximized dipping volume for gravure printing was developed and investigated. A design rule for this kind of screens was realized and verified by a successful manufacturing of electrodes with different dried layer thicknesses. Due to the rough structure and the high dipping volumes of these line screens an adaption and optimization of the machinery and the whole process was necessary to achieve high quality electrodes. Finally, it is shown that it is possible to manufacture continuiously in an industrial close roll-to-roll process platinum loaded electrodes, working successful as cathode in a Membran-Electrode-Assembly
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Bonifacio, Rafael Nogueira. "Desenvolvimento de processo de produção de conjuntos eletrodo-membrana-eletrodo para células a combustível baseadas no uso de membrana polimérica condutora de prótons (PEMFC) por impressão a tela." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-29082011-151940/.
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Energia é um recurso que historicamente apresenta tendência de crescimento de demanda. Projeções indicam que, para suprir as necessidades energéticas do futuro, será necessário um uso massivo do hidrogênio como combustível. O uso de sistemas de célula a combustível baseada no uso de membrana polimérica condutora de prótons (PEMFC) tem características que permitem sua aplicação para geração de energia elétrica em aplicações estacionárias, automotivas e portáteis. O uso de hidrogênio como combustível para PEMFC apresenta a vantagem de resultar em baixa emissão de poluentes quando comparado às dos combustíveis fósseis. Para que ocorram as reações em uma PEMFC é necessária a construção de conjuntos eletrodo-membrana-eletrodo (MEA), sendo o processo de produção de MEAs e os materiais utilizados, relevantes no custo final do kW instalado para geração de energia por sistemas de célula a combustível, o que é, atualmente, uma barreira tecnológica e financeira para a aplicação em grande escala desta tecnologia. Nesse trabalho foi desenvolvido um processo de produção de MEAs por impressão a tela que apresenta alta reprodutibilidade, rapidez e baixo custo. Foram desenvolvidos o processo de impressão a tela e a composição de uma tinta precursora da camada catalisadora (TPCC), que permitem o preparo de eletrodos para confecção de MEAs com a aplicação da massa exata de eletrocatalisador adequada para cátodos 0,6 miligramas de platina por centímetro quadrados (mgPt.cm-2) e ânodos 0,4 mgPt.cm-2 em apenas uma aplicação por eletrodo. A TPCC foi desenvolvida, produzida, aplicada e caracterizada, apresentando características semelhantes a de tintas de impressão a tela para outras aplicações. Os MEAs produzidos apresentaram desempenho de até 712 mA.cm-2 a 600 mV para MEAs de 25 cm2 e o custo para produção de MEAs de 247,86 cm2 capazes de gerar 1 kW de energia foi estimado em R$ 13.939,45, considerando custo de equipamentos, materiais e mão de obra.<br>Energy is a resource that presents historical trend of growth in demand. Projections indicate that future energy needs will require a massive use of hydrogen as fuel. The use of systems based on the use of proton exchange membrane fuel cell (PEMFC) has features that allow its application for stationary applications, automotive and portable power generation. The use of hydrogen as fuel for PEMFC has the advantage low pollutants emission, when compared to fossil fuels. For the reactions in a PEMFC is necessary to build membrane electrode assembly (MEA). And the production of MEAs and its materials are relevant to the final cost of kW of power generated by systems of fuel cell. This represent currently a technological and financial barriers to large-scale application of this technology. In this work a process of MEAs fabrication were developed that showed high reproducibility, rapidity and low cost by sieve printing. The process of sieve printing and the ink composition as a precursor to the catalyst layer were developed, which allow the preparation of electrodes for MEAs fabrication with the implementation of the exact catalyst loading, 0.6 milligrams of platinum per square centimeters (mgPt.cm-2) suitable for cathodes and 0.4 mgPt.cm-2 for anode in only one application step per electrode. The ink was developed, produced, characterized and used with similar characteristics to ink of sieve printing build for other applications. The MEAs produced had a performance of up to 712 mA.cm-2 by 600 mV to 25 cm2 MEA area. The MEA cost production for MEAs of 247.86 cm2, that can generate 1 kilowatt of energy was estimated to US$ 7,744.14 including cost of equipment, materials and labor.
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Rajtrová, Gabriela. "Změna organizace výrobních linek." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2009. http://www.nusl.cz/ntk/nusl-222298.
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The main goal of this diploma thesis is new lay – out of organizational structure of assembly lines, which is leading to the material flow shortening and elimination of problems with factionalism of industrial process. In this thesis is introduce the company, where is proposed new organizational structure of assembly lines, together with description of deficiencies current organization. The good know ledges of assembly process and technology is important for the right modification. According theoretic findings it was proposed new organizational structure of assembly lines and the cost saving was calculated
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Huang, Shih-Yu, and 黃士羽. "Investigation of cell assembly process for electrowetting display." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/3f9zz3.
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碩士<br>國立中興大學<br>精密工程學系所<br>101<br>Electrowetting display is considered as the most developed and innovative displays, however, there are some restrictions on production. For this paper we have succeeded in solving the problem of electro-wetting display assembly by TFT-LCD ODF (one drop fill) assembly process, it will be compatible to the TFT-LCD production line for mass production and lower costs. In addition, we designed the structure of electrowetting light valve with some advantages, such as high contrast, high brightness and lower response time possibly for e-reader. Furthermore, we also demonstrate that the thickness of 2 drops ink correspond to 4um with a lower driving voltage 10V.
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Li, Kuan-Ying, and 李冠穎. "Using PCB digital assembly process to preparation and characterization for Direct Methanol Fuel Cell." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/qx8b56.
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碩士<br>國立臺北科技大學<br>製造科技研究所<br>101<br>This study aims to deal with the preparation of membrane-electrolyte assembly (MEA) of Pt/Ru/CB nanocomposite as well as connecting to a direct methanol fuel cell and using PCB process packaging to test the efficiency of the DMFC. The components assembled in DMFC are including anode flow field plates, MEA and current collector.Using PCB boards for the anode flow field plates as well as the electicity collector plates and the type of flow field plate adopts serpentine flow field. Pt/Ru/CB MEA developed in this study uses carbon paper as main body, assembling Pt/Ru/CB MEA in two sides respectively and combining with gas diffusion layer (GDL) in the most lateral and assembling with the hot-pressing units. For the efficiency of DMFC, liquid motors are used to press methanol mixed solution at specific temperature into DMFC. Besides, the cathode of DMFC adopts natural-breath method with air and uses DC electronic load to activate DMFC to investigate operating voltage (OCV) and further to set constant voltage to measure current to calculate the efficiency of DMFC. In addition, Transmission electron microscope TEM is employed to measure the structure of Pt/Ru/CB MEA. Initial results of I-V curve show that self-developed MEA of Pt/Ru/C nanocomposite can enhance around 0.2% current density of DMFC after being assembled like commercial MEA.
Books on the topic "Cell assembly process"
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Sherwood, Dennis, and Paul Dalby. Thermodynamics today – and tomorrow. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198782957.003.0026.
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This last chapter explores the frontiers of how thermodynamics is currently being applied to biology, moving from the scale of the molecule to the scale of the cell. The key theme is ‘self-assembly’ – the process by which macromolecules spontaneously assemble into larger structures such as cell membranes, cell organelles, cells, and ultimately organisms. The starting point is the simplest process of self-assembly, the formation of a liquid from the condensation of a gas, which draws on some results from Chapter 15, and develops the concept of nucleation, this leads to a discussion of protein aggregation, and how virus particles are formed. The chapter, and the book, ends with a key challenge for the future: how can we deliberately design self-assembling systems that can perform valuable functions?
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Davis, Scott F. Synchronous cell manufacturing versus traditional assembly lines: A project in Industrial Technology. 1995.
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Moses, Matthew S., and Gregory S. Chirikjian. Reproduction. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199674923.003.0007.
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Computing pioneer and polymath John von Neumann introduced the concept of a Universal Constructor as part of his effort to develop a mathematical theory describing living organisms. A Universal Constructor is a kinematic machine able to manipulate and assemble primitive building blocks. Von Neumann showed how this hypothetical constructor, being itself composed of the same primitive blocks, could self-reproduce and evolve. Remarkably, although this model system pre-dates the discovery of the genetic code, it applies to cell molecular biology as well as man-made machines. This chapter describes some key laboratory demonstrations related to universal construction and machine self-reproduction, and discusses parallels between reproduction processes in machines and biological cells.
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Salinas-Rodríguez, Sergio G., Juan Arévalo, Juan Manuel Ortiz, et al., eds. Microbial Desalination Cells for Low Energy Drinking Water. IWA Publishing, 2021. http://dx.doi.org/10.2166/9781789062120.
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The world's largest demonstrator of a revolutionary energy system in desalination for drinking water production is in operation. MIDES uses Microbial Desalination Cells (MDC) in a pre-treatment step for reverse osmosis (RO), for simultaneous saline stream desalination and wastewater treatment. MDCs are based on bio-electro-chemical technology, in which biological wastewater treatment can be coupled to the desalination of a saline stream using ion exchange membranes without external energy input. MDCs simultaneously treat wastewater and perform desalination using the energy contained in the wastewater. In fact, an MDC can produce around 1.8 kWh of bioelectricity from the energy contained in 1 m3 of wastewater. Compared to traditional RO, more than 3 kWh/m3 of electrical energy is saved. With this novel technology, two low-quality water streams (saline stream, wastewater) are transformed into two high-quality streams (desalinated water, treated wastewater) suitable for further uses. An exhaustive scaling-up process was carried out in which all MIDES partners worked together on nanostructured electrodes, antifouling membranes, electrochemical reactor design and optimization, life cycle assessment, microbial electrochemistry and physiology expertise, and process engineering and control. The roadmap of the lab-MDC upscaling goes through the assembly of a pre-pilot MDC, towards the development of the demonstrator of the MDC technology (patented). Nominal desalination rate between 4-11 Lm-2h-1 is reached with a current efficiency of 40 %. After the scalability success, two MDC pilot plants were designed and constructed consisting of one stack of 15 MDC pilot units with a 0.4 m2 electrode area per unit. This book presents the information generated throughout the EU funded MIDES project and includes the latest developments related to desalination of sea water and brackish water by applying microbial desalination cells. ISBN: 9781789062113 (Paperback) ISBN: 9781789062120 (eBook)
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Brown, Ronald T., ed. Comprehensive Handbook of Childhood Cancer and Sickle Cell Disease. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195169850.001.0001.
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Over recent decades, tremendous advances in the prevention, medical treatment, and quality of life issues in children and adolescents surviving cancer have spawned a host of research on pediatric psychosocial oncology. This important volume fulfills the clear need for an up-to-date, comprehensive handbook for practitioners that delineates the most recent research in the field--the first of its kind in over a decade. Over 60 renowned authors have been assembled to provide a thorough presentation of the state-of-the art research and literature, with topics including: -Neuropsychological effects of chemotherapy and radiation therapy -Bone marrow transplantation -Important issues about quality of life during and following treatment -Collaborative research among child-focused psychologists -Standards of psychological care for children and adolescents -Stress and coping in the pediatric cancer experience -The role of family and peer relationships The Comprehensive Handbook of Childhood Cancer and Sickle Cell Disease represents both multidisciplinary and international efforts, an alliance between physicians and parents, and a combination of research and service. With a wealth of information of great interest to patients and their families, this volume will also be a welcome resource to the psychologists, psychiatrists, pediatricians, oncologists, nurses, and social workers who confront these issues as they help children and their families through the treatment, recovery, and grieving processes.
Book chapters on the topic "Cell assembly process"
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Sanderson, David, Emma Shires, Jack C. Chaplin, Harvey Brookes, Amer Liaqat, and Svetan Ratchev. "Context-Aware Plug and Produce for Robotic Aerospace Assembly." In IFIP Advances in Information and Communication Technology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-72632-4_13.
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AbstractAerospace production systems face increasing requirements for flexibility and reconfiguration, along with considerations of cost, utilisation, and efficiency. This drives a need for systems with a small number of automation platforms (e.g. industrial robots) that can make use of a larger number of end effectors that are potentially flexible or multifunctional. This leads to the challenge of ensuring that the configuration and location of each end effector is tracked by the system at all times, even in the face of manual adjustments, to ensure that the correct processes are applied to the product at the right time. We present a solution based on a Data Distribution Service that provides the system with full awareness of the context of its automation platforms and end effectors. The solution is grounded with an example use case from WingLIFT, a research programme led by a large aerospace manufacturer. The WingLIFT project in which this solution was developed builds on the adaptive systems approach from the Evolvable Assembly Systems project, with focus on extending and increasing the aerospace industrial applicability of plug and produce techniques. The design of this software solution is described from multiple perspectives, and accompanied by details of a physical demonstration cell that is in the process of being commissioned.
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Viturawong, Y., S. Chongthammakun, N. Niamsiri, T. Srikhirin, and T. Osotchan. "Viscoelastic Property and Cell Adhesion Process of Cultured Fibroblasts on Different Self-assembled Monolayers Monitored by Acoustic Wave Biosensor." In IFMBE Proceedings. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-02913-9_81.
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M. Bijonowski, Brent. "Spatiotemporal Regulation of Cell–Cell Adhesions." In Epigenetics to Optogenetics - A New Paradigm in the Study of Biology [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97009.
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Cell–cell adhesions are fundamental in regulating multicellular behavior and lie at the center of many biological processes from embryoid development to cancer development. Therefore, controlling cell–cell adhesions is fundamental to gaining insight into these phenomena and gaining tools that would help in the bioartificial construction of tissues. For addressing biological questions as well as bottom-up tissue engineering the challenge is to have multiple cell types self-assemble in parallel and organize in a desired pattern from a mixture of different cell types. Ideally, different cell types should be triggered to self-assemble with different stimuli without interfering with the other and different types of cells should sort out in a multicellular mixture into separate clusters. In this chapter, we will summarize the developments in photoregulation cell–cell adhesions using non-neuronal optogenetics. Among the concepts, we will cover is the control of homophylic and heterophilic cell–cell adhesions, the independent control of two different types with blue or red light and the self-sorting of cells into distinct structures and the importance of cell–cell adhesion dynamics. These tools will give an overview of how the spatiotemporal regulation of cell–cell adhesion gives insight into their role and how tissues can be assembled from cells as the basic building block.
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Jeffery-Smith, Anna, and C. Y. William Tong. "The Biology of Viruses." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0008.
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In order to be classified as a virus, certain criteria have to be fulfilled. Viruses must ● Be only capable of growth and multiplication within living cells, i.e. obligate intracellular parasite. Host cells could include humans, animals, insects, plants, protozoa, or even bacteria. ● Have a nucleic acid genome (either RNA or DNA, but not both) surrounded by a protein coat (capsid). ● Have no semipermeable membrane, though some have an envelope formed of phospholipids and proteins. ● Be inert outside of the host cell. Enveloped viruses are susceptible to inactivation by organic solvents such as alcohol. ● Perform replication by independent synthesis of components followed by assembly (c.f. binary fission in bacteria). Viruses are considered as a bundle of genetic programmes encoded in nucleic acids and packaged with a capsid +/ - envelope protein, which can be activated on entry into a host cell (compare this with computer viruses packaged in an enticing way in order to infect and take over control of your PC). Although they share some similarities in their properties, mycoplasma and chlamydia are true bacteria. The virion (assembled infectious particle) consists of viral nucleic acid and capsid. The nucleic acid of a virus can either be ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), and the amount of genetic material varies widely, with some viruses able to encode a few proteins and others having genetic material that encodes hundreds of proteins. In association with the nucleic acid there may be non- structural viral proteins, such as a viral polymerase. The nucleic acid and non- structural proteins are protected by a surrounding layer of capsid proteins. The capsid includes proteins which can attach to host cell receptors. The proteins and the cell receptors to which they bind determine a virus’ tropism, i.e., the ability to bind to and enter different cell types. The term nucleocapsid refers to the nucleic acid core surrounded by capsid protein. Some viruses also have an envelope made up of phospholipids and proteins surrounding the nucleocapsid. This envelope can be formed by the host cell membrane during the process of a virus budding from a cell during replication.
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Simpson, Michael L., and Gary S. Sayler. "The Device Science of Whole Cells as Components in Microscale and Nanoscale Systems." In Cellular Computing. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780195155396.003.0009.
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Intact whole cells may be the ultimate functional molecular-scale machines, and our ability to manipulate the genetic mechanisms that control these functions is relatively advanced when compared to our ability to control the synthesis and direct the assembly of man-made materials into systems of comparable complexity and functional density. Although engineered whole cells deployed in biosensor systems provide one of the practical successes of molecular-scale devices, these devices explore only a small portion of the full functionality of the cells. Individual or self-organized groups of cells exhibit extremely complex functionality that includes sensing, communication, navigation, cooperation, and even fabrication of synthetic nanoscopic materials. Adding this functionality to engineered systems provides motivation for deploying whole cells as components in microscale and nanoscale devices. In this chapter we focus on the device science of whole cell components in a way analogous to the device physics of semiconductor components. We consider engineering the information transport within and between cells, communication between cells and synthetic devices, the integration of cells into nanostructured and microstructured substrates to form highly functional systems, and modeling and simulation of information processing in cells. Even a casual examination of the information processing density of prokaryotic cells produces an appreciation for the advanced state of the cell’s capabilities. A bacterial cell such as Escherichia coli ( 2 μm2 cross-sectional area) with a 4.6 million basepair chromosome has the equivalent of a 9.2-megabit memory. This memory codes for as many as 4300 different polypeptides under the inducible control of several hundred different promoters. These polypeptides perform metabolic and regulatory functions that process the energy and information, respectively, made available to the cell. This complexity of functionality allows the cell to interact with, influence, and, to some degree, control its environment. Compare this to the silicon semiconductor situation as described in the International Technology Roadmap for Semiconductors (ITRS). ITRS predicts that by the year 2014, memory density will reach 24.5 Gbits/cm2, and logic transistor density will reach 664 M/cm2. Assuming four transistors per logic function, 2 μm2 of silicon could contain a 490-bit memory or approximately three simple logic gates.
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Deamer, David W. "Self-Assembly Processes Were Essential for Life’s Origin." In Assembling Life. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190646387.003.0010.
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In the absence of self-assembly processes, life as we know it would be impossible. This chapter begins by introducing self-assembly then focuses on the primary functions of membranes in living cells, most of which depend on highly evolved proteins embedded in lipid bilayers. These serve to capture light energy in photosynthesis and produce ion concentration gradients from which osmotic energy can be transduced into chemical energy. Although lipid bilayer membranes provide a permeability barrier, they cannot be absolutely impermeable because intracellular metabolic functions depend on external sources of nutrients. Therefore, another set of embedded proteins evolved to form transmembrane channels that allow selective permeation of certain solutes. The earliest life did not have proteins available, so in their absence what was the primary function of membranous compartments in prebiotic conditions? There are three possibilities. First, the compartments would allow encapsulated polymers to remain together as random mixtures called protocells. Second, populations of protocells that vary in composition would be subject to selective processes and the first steps of evolution. Even though any given protocell would be only transiently stable, certain mixtures of polymers would tend to stabilize the surrounding membrane. Such an encapsulated mixture would persist longer than the majority that would be dispersed and recycled, and these more robust protocells would tend to emerge as a kind of species. Last and perhaps most important, there had to be a point in early evolution at which light energy began to be captured by membranous structures, just as it is today. Bilayer membranes are not necessarily composed solely of amphiphilic molecules. They can also contain other nonpolar compounds that happen to be pigments capable of capturing light energy. This possibility is almost entirely unexplored, but the experiments are obvious and would be a fruitful focus for future research. Questions to be addressed: What is meant by self-assembly? Why is self-assembly important for the origin of life? What compounds can undergo self-assembly processes? How can mixtures of monomers and lipids assemble into protocells? We tend to think of living cells in terms of directed assembly.
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Buzsáki, György. "Internally Organized Cell Assembly Trajectories." In The Brain from Inside Out. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190905385.003.0007.
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Sequences of neuronal patterns are not always imposed on brain circuits in an outside-in manner by the sensory inputs. Internally organized processes can sustain self-organized and coordinated neuronal activity even without external inputs. A prerequisite of cognition is the availability of internally generated neuronal sentences. Self-generated, sequentially evolving activity is the default state of affairs in most neuronal circuits. Neuronal activity moves perpetually, and its trajectory depends only on initial conditions. Large recurrent networks can generate an enormous number of trajectories without prior experience. On the other hand, each is available to be matched by experience to “represent” something useful for the downstream reader mechanisms. The richness of the information depends not on the numbers of generated sequences but on the reader mechanisms. It is typically the reader structure that initiates the transfer of information, coordinating the onset of messages from multiple senders.
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Villas-Boas, Mauro, and Ana Sepulveda De Rezende. "Exploring Structural, Functional, and Kinetic Aspects of Nucleic Acid–Protein Complexes with Pressure: Nucleosomes and RNA Polymerase." In High Pressure Effects in Molecular Biophysics and Enzymology. Oxford University Press, 1996. http://dx.doi.org/10.1093/oso/9780195097221.003.0012.
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High pressure has provided us with new insights into two complex DNA-protein systems: nucleosomes and RNA polymerase. In spite of their complexity, we can derive new and useful information about them by coupling high pressure with a variety of other physical techniques and functional assays. These studies have shown clearly that multiple conformations of these large–molecular weight DNA-protein assemblies are present simultaneously in solution, although both molecular assemblies are generally considered to be single structures in most in vitro experiments. Considering the variety of different cellular situations encountered by nucleosomes and RNA polymerases, it is perhaps to be expected that evolution would select structures with flexible and multifarious conformations that possesses sufficient stability, rather than static, rigid, singular, and highly stable structures. The molecular organization in the nucleus of a biological cell is extensive and involves intricate protein-protein and protein–nucleic acid interactions that are changing continually during the cell cycle. These dynamic activities in the nucleus are tightly coordinated with many extranuclear events throughout the cell. Highly organized molecular complexes involving multisubunit proteins (and higher order protein assemblies) interacting with the nucleic acid components are the rule rather than the exception in the nucleus (Alberts et al., 1983; Darnell et al., 1990; Lewin, 1994). For instance, chromosomes are organized in a structural hierarchy culminating in the metaphase state in which they are packed tightly together with proteins in a highly specific and economical manner that still largely eludes our understanding; the DNA of a eukaryotic cell is replicated with the help of a complex assembly of proteins; and information coded within the DNA sequence is transcribed with the assistance of multisubunit DNA-binding proteins, some acting as enzymes and others serving mainly as organizational and structural assistants to the catalytic process. Many important features of protein-nucleic acid (DNA and RNA) interactions have been elucidated in the last decade (Pabo & Sauer, 1992; Steitz, 1990), and exciting results have been obtained for singleprotein molecules and dimers binding to DNA. Although we are a long way from understanding these interactions completely, enough aspects are known so that structural predictions are sometimes possible simply from the amino acid sequence.
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Fambrough, Douglas M., M. Victor Lemas, Kunio Takeyasu, Karen J. Renaud, and Elizabeth M. Inman. "Chapter 3 Structural Requirements for Subunit Assembly of the Na, K-ATPase." In Cell Biology and Membrane Transport Processes. Elsevier, 1994. http://dx.doi.org/10.1016/s0070-2161(08)60453-0.
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Saltzman, W. Mark. "Tissue Barriers to Molecular and Cellular Transport." In Tissue Engineering. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780195141306.003.0014.
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Previous chapters have revealed the importance of molecular diffusion in tissue engineering. Molecules—and gradients of molecules—may represent the underlying mechanism of tissue induction and pattern formation (Chapter 3); growth factors—and the rate of delivery of growth factors to a cell surface—can influence the rate of cell proliferation (Chapter 4); chemoattractants can influence the rate and pattern of cell migration within a tissue space (Chapter 7). To think quantitatively about these processes, it is often helpful to think about molecular concentrations and the spatial variations in concentration that produce diffusion fluxes. This idea has been illustrated earlier in the book for specific examples such as bicoid gradient formation in the insect embryo (Section 3.3.4) and ligand diffusion to the cell surface (Section 4.3.2). Some of the basic concepts of molecular transport are also reviewed in Appendix B. But tissues are often heterogeneous structures, formed by the assembly of cells and the accumulation of matrix materials in the extracellular space. The heterogeneous composition of tissues can have a dramatic influence on local rates of molecular movement through the tissue; capillary endothelial cells prevent the diffusion of intravascular proteins into the tissue interstitial space, for example. This chapter discusses this concept and provides quantitative methods for evaluating rates of molecular movement between tissue spaces that are separated by diffusive barriers. In addition, the last section of the chapter shows how this same analysis may be useful when thinking about rates of cellular movement between tissue compartments. In multicellular organisms, thin lipid membranes serve as semipermeable barriers between aqueous compartments. The plasma membrane of the cell separates the cytoplasm from the extracellular space; endothelial cell membranes separate the blood within the vascular space from the rest of the tissue. Properties of the lipid membrane are critically important in regulating the movement of molecules between aqueous spaces. While certain barrier properties of membranes can be attributed to the lipid components, accessory molecules within the cell membrane—particularly transport proteins and ion channels—control the rate of permeation of many solutes.
Conference papers on the topic "Cell assembly process"
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Abu-Hamdan, M. G., and A. Sherif El-Gizawy. "Development of an Autonomous Assembly Cell." In ASME 1994 Design Technical Conferences collocated with the ASME 1994 International Computers in Engineering Conference and Exhibition and the ASME 1994 8th Annual Database Symposium. American Society of Mechanical Engineers, 1994. http://dx.doi.org/10.1115/detc1994-0372.
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Abstract The problem of implementing intelligent control structure in real world flexible assembly environment is discussed and the development of a sensory-based system is described. The new system possesses the ability to deal with assembly process environment as an autonomous one. The use of an integrated sensory devices not only enhances the accuracy of the assembly operations by providing measurements and information feedback, but also makes the entire system more robust in the presence of uncertainties due to operational errors.
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Laskowski, Christina, and Stephen Derby. "Fuel Cell ASAP: Two Iterations of an Automated Stack Assembly Process and Ramifications for Fuel Cell Design-for-Manufacture Considerations." In ASME 2009 7th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2009. http://dx.doi.org/10.1115/fuelcell2009-85231.
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Polymer-electrode membrane (PEM) fuel cell technology, a low-emissions power source receiving much attention for its efficiency, will need to progress from low-volume production to high-volume within the course of the next decade. To successfully achieve this transition, significant research progress has already been made towards developing a fully-functional fuel cell automatic stack assembly robotic station. Lessons can be drawn from this research with regards to design-for-manufacture (DFM) and design-for-assembly (DFA) considerations of fuel cells; however, more work still remains to be done. This document outlines both iterations of the robotic fuel cell assembly stations, other work to date, DFM and DFA lessons learned, and the anticipated future progression of automatic fuel cell stack assembly stations. A literature search reveals numerous patents pertaining to equipment and processes for fuel cell assembly as well as a great number of patents pertaining to fuel cell stack features to aid in manufacture or assembly. However, most of this is focused upon proper compression of the membrane material, with little thought given to overall assembly and throughput. Journal articles have begun to consider real-world manufacturing considerations pertinent to production scale-up, but much remains to be done. Therefore, there is a need for more contributions to stack manufacture and assembly. Work already completed (by the authors and their lab) towards the manufacturing workcell specifically includes the design and construction of two individual robotic fuel cell assembly stations, including custom-built end effectors and parts feeders. The second station incorporated numerous improvements, including overlapping work envelopes, elimination of a shuttle cart, software synchronization, fewer axes, and a better end effector. Consequentially, the second workcell achieved a four-fold improvement in cycle time over the previous iteration. Future improvements will focus in part upon improving the reliability of the overall system. Close study of the manufacturing workcell indicated that stack component design features are key for production and scale-up of fuel cell stack manufacturing processes. Critical features are discussed in this article, as well as their ramifications for the overall stack design. As the stack assembly workcell continues to improve, research will focus upon the ramifications and interplay of tolerances, stack failure modes, sealing, reliability, and the potential for component redesign specifically to optimize fuel cell manufacturing throughput.
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Hruskova, Erika, Radovan Holubek, and Karol Velisek. "The Possibilities of Increasing the Flexibility of Intelligent Assembly Cell." In ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2010. http://dx.doi.org/10.1115/esda2010-24460.
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In relation to how the complexity of modern assembly technology increases, requirements for precise, fast and relevant information specifically for the assemble process also increase. Automation allows the fast and precise measurement of various parameters, assessment of the values obtained and the implementation of the required measures in real time. Automation tools allow evaluation, parameter measurement, comparison and application via computer technology and various software resources. One of the aims of the VEGA 1/0206/09 Intelligent assembly cell project solution as per our institute is the creation of a means of forming assembly cells, their duly defined critical placements, verification of the assembly process as a dynamic system of consistency from a technological, handling and control sub-system point of view via means of 3D models in CATIA environment software. Authors of this paper are members and experts of project group (VEGA 1/0206/09) interested in robotics, manipulators and technological devices. Whereas mechanical production trends in the 21st century tend to focus more on resilience and flexibility, the authors of this article have taken into consideration the possibility of re-evaluating the above-mentioned data — which is an essential element in terms of raising flexibility, thus definitively contributing to increased competitiveness.
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Laskowski, Christina, and Stephen Derby. "Fuel Cell ASAP: Two Iterations of an Automated Stack Assembly Process and Ramifications for Fuel Cell Design-for-Manufacture Considerations." In ASME 2009 International Manufacturing Science and Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/msec2009-84104.
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Polymer-electrode membrane (PEM) fuel cell technology will need to progress from low-volume production to high-volume within the course of the next decade. To successfully achieve this transition, a fully-functional fuel cell automatic stack assembly robotic station is being developed. This document outlines both iterations of the robotic fuel cell assembly stations, other work to date, DFM and DFA lessons learned, and the anticipated future progression of automatic fuel cell stack assembly stations. Two individual robotic fuel cell assembly stations were constructed, including custom-built end effectors and parts feeders. The second station incorporated numerous improvements, including overlapping work envelopes, elimination of a shuttle cart, software synchronization, fewer axes, and a better end effector. Consequentially, the second workcell achieved a four-fold improvement in cycle time over the previous iteration. Future improvements will focus in part upon improving the reliability of the overall system. As the stack assembly workcell continues to improve, research will focus upon the ramifications and interplay of tolerances, stack failure modes, sealing, reliability, and the potential for component redesign specifically to optimize fuel cell manufacturing throughput.
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Montagnier, P. "Design of a graphical user interface (GUI) between a PC-based CAD system and a flexible assembly robotic cell." In Fifth International Conference on FACTORY 2000 - The Technology Exploitation Process. IEE, 1997. http://dx.doi.org/10.1049/cp:19970139.
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Wilson, Christopher G., and Marc E. Levenston. "Chondrocytes and Fibrochondrocytes Differentially Process Aggrecan During De Novo Extracellular Matrix Assembly." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176669.
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The material properties of articular cartilage and meniscal fibrocartilage depend on the composition and ultrastructure of the extracellular matrix (ECM). Aggrecan is the predominant large proteoglycan in these tissues, and confers compressive stiffness through immobilization of negatively charged sulfated glycosaminoglycans (sGAG). The abundance of sGAG is in part regulated by cell-mediated proteolysis of the aggrecan core protein, and transforming growth factor-β (TGF-β) family cytokines upregulate aggrecan synthesis in chondrocytes and fibrochondrocytes. The function(s) of aggrecan and mechanisms of aggrecan processing in the meniscus, however, are not well understood. The objective of this study was to examine tissue-specific kinetics and mechanisms of TGF-β-induced aggrecan turnover using the cell-agarose culture system. In addition, the tissue-specific functional implications of increased proteoglycan production were evaluated in terms of construct material properties.
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Ciszak, Olaf. "Modeling and Simulation of Technological Assembly Process With Utilization of MTBF Parameter." In ASME 2014 12th Biennial Conference on Engineering Systems Design and Analysis. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/esda2014-20457.
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The present study deals with vital aspects of technological assembly process modeling and simulation based on application of the MTBF (Mean Time Between Failures) parameter, as exemplified upon experimental assembly of an automobile disc brake caliper unit. The proposed simulation model of the analyzed assembly work cell is hereby expounded upon. The paper further presents the outcomes and conclusions of the undertaken experimental procedure.
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Tsvankin, Vadim, Dmitry Belchenko, Devon Scott, and Wei Tan. "Anisotropic Strain Effects on Vascular Smooth Muscle Cell Physiology." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176284.
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Biological development is a complex and highly-regulated process, a significant part of which is controlled by mechanostimulus, or the strain imparted on a cell by its environment. Mechanostimulus is important for stem cell differentiation, from cytoskeletal assembly to cell-cell and cell-matrix adhesion [1]. The mechanics of cells and tissues play a critical role in organisms, under both physiological and pathological conditions; abnormal mechanotransduction — the mechanism by which cells sense and respond to strain — has been implicated in a wide range of clinical pathologies [2,3].
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Agarwal, Gunjan, and Carol Livermore. "Templated Assembly by Selective Removal for Size-Selective Sorting of Biological Materials." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13128.
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This work presents the size-selective sorting of single biological cells using the assembly process known as Templated Assembly by Selective Removal (TASR). We have demonstrated experimentally, for the first time, the selective self assembly and sorting of single SF9 cells (a clonal isolate, derived from Spodoptera frugiperda (Fall Armyworm) IPLB-Sf21-AE cells) into patterned hemispherical sites on rigid assembly templates using TASR. TASR-based size-selective assembly of biological systems represents a potentially valuable tool, with potential for implementation in several biological applications, such as cell sorting for medical research or diagnostics, or isolation of single cells for the study of biological or mechanical behavior.
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Zhu, Qingfu, Ziyu Zhu, and Mei He. "3D Additive Manufacturing and Micro-Assembly for Transfection of 3D-Cultured Cells and Tissues." In ASME 2018 13th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/msec2018-6567.
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3D additive manufacturing, namely 3D printing, has been increasingly needed in the fabrication of biological materials and devices. Compared to traditional fabrication, direct 3D digital transformation simplifies the manufacturing process and enhances capability in geometric fabrication. In this paper, we demonstrated a rapid and low-cost 3D printing approach for “lego” assembly of micro-structured parts as an electro-transfection device. Electro-transfection is an essential equipment for engineering and regulating cell biological functions. Nevertheless, existing platforms are mainly employed to monolayer cell suspensions in vitro, which showed more failures for translating into tissues and in vivo systems constituted by 3D cells. The knowledge regarding the three-dimensional electric transport and distribution in a tissue microenvironment is lacking. In order to bridge the gap, we assembled PDMS parts molded from 3D-printed molds as the 3D-cell culture chamber, which connects arrays of perfusion channels and electrodes. Such design allows spatial and temporal control of electric field uniformly across a large volume of 3D cells (105∼106 cells). Most importantly, multi-dimensional electric frequency scanning creates local oscillation, which can enhance mass transport and electroporation for improving transfection efficiency. The COMSOL electrostatic simulation was employed for proof of concept of 3D electric field distribution and transport in this “lego” assembled electro-transfection device, which builds the foundation for engineering 3D-cultured cells and tissues.
Reports on the topic "Cell assembly process"
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Nowlan, M. Automated solar cell assembly teamed process research. Semiannual subcontract report, December 6, 1993--June 30, 1994. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/10109616.
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Nowlan, M. J., S. J. Hogan, G. Darkazalli, et al. Automated solar cell assembly team process research. Annual subcontract report, 1 January 1993--31 December 1993. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/10157624.
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Nowlan, M. J., S. J. Hogan, W. F. Breen, et al. Automated Solar Cell Assembly Teamed Process Research. Final subcontract report, 6 January 1993--31 October 1995. Office of Scientific and Technical Information (OSTI), 1996. http://dx.doi.org/10.2172/219251.
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Nowlan, M. J., S. J. Hogan, G. Darkazalli, W. F. Breen, J. M. Murach, and S. F. Sutherland. Automated Solar Cell Assembly Teamed Process Research: Semiannual Subcontract Report, 7 January 1993 - 30 June 1993. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/10131199.
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