Journal articles on the topic 'CDK17'
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Liu, Mingfa, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, and Haixiong Xu. "The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis." Journal of Immunology Research 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/1278081.
Full textLiang, Kaiwei, Xin Gao, Joshua M. Gilmore, Laurence Florens, Michael P. Washburn, Edwin Smith, and Ali Shilatifard. "Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing." Molecular and Cellular Biology 35, no. 6 (January 5, 2015): 928–38. http://dx.doi.org/10.1128/mcb.01426-14.
Full textLier, S., I. Rein, S. Lund, A. Lång, E. Lång, N. Meyer, A. Dutta, et al. "P10.12.A CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival." Neuro-Oncology 24, Supplement_2 (September 1, 2022): ii51. http://dx.doi.org/10.1093/neuonc/noac174.177.
Full textKohoutek, Jiri, and Dalibor Blazek. "Cyclin K goes with Cdk12 and Cdk13." Cell Division 7, no. 1 (2012): 12. http://dx.doi.org/10.1186/1747-1028-7-12.
Full textFan, Zheng, Jennifer R. Devlin, Simon J. Hogg, Maria A. Doyle, Paul F. Harrison, Izabela Todorovski, Leonie A. Cluse, et al. "CDK13 cooperates with CDK12 to control global RNA polymerase II processivity." Science Advances 6, no. 18 (April 29, 2020): eaaz5041. http://dx.doi.org/10.1126/sciadv.aaz5041.
Full textShah, Muzna, Muhammad Fazal Hussain Qureshi, Danish Mohammad, Mahira Lakhani, Tabinda Urooj, and Shamim Mushtaq. "CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions." Asian Pacific Journal of Cancer Biology 5, no. 1 (February 25, 2020): 1–9. http://dx.doi.org/10.31557/apjcb.2020.5.1.1-9.
Full textZhang, Bo, Xuelin Zhong, Moira Sauane, Yihong Zhao, and Zhi-Liang Zheng. "Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy." Cells 9, no. 3 (March 4, 2020): 621. http://dx.doi.org/10.3390/cells9030621.
Full textGuiro, Joana, Mathias Fagbemi, Michael Tellier, Justyna Zaborowska, Stephanie Barker, Marjorie Fournier, and Shona Murphy. "CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors." Biomolecules 12, no. 5 (May 14, 2022): 704. http://dx.doi.org/10.3390/biom12050704.
Full textQuereda, Victor, Simon Bayle, Francesca Vena, Sylvia M. Frydman, Andrii Monastyrskyi, William R. Roush, and Derek R. Duckett. "Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer." Cancer Cell 36, no. 5 (November 2019): 545–58. http://dx.doi.org/10.1016/j.ccell.2019.09.004.
Full textZhang, Tinghu, Nicholas Kwiatkowski, Calla M. Olson, Sarah E. Dixon-Clarke, Brian J. Abraham, Ann K. Greifenberg, Scott B. Ficarro, et al. "Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors." Nature Chemical Biology 12, no. 10 (August 29, 2016): 876–84. http://dx.doi.org/10.1038/nchembio.2166.
Full textGreenleaf, Arno L. "Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium." Transcription 10, no. 2 (October 22, 2018): 91–110. http://dx.doi.org/10.1080/21541264.2018.1535211.
Full textVaradarajan, Ramya, Joseph Ayeni, Zhigang Jin, Ellen Homola, and Shelagh D. Campbell. "Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes." Molecular Biology of the Cell 27, no. 13 (July 2016): 2051–63. http://dx.doi.org/10.1091/mbc.e16-02-0104.
Full textPraditsuktavorn, Pannee, Benet Pera, Nicholas Kwiatkowski, ShaoNing Yang, Tinghu Zhang, Nathanael Gray, and Leandro Cerchietti. "Transcription Regulation Targeting in Peripheral T Cell Lymphomas Induces Apoptosis and Sensitization to BCL2 Inhibitors." Blood 124, no. 21 (December 6, 2014): 810. http://dx.doi.org/10.1182/blood.v124.21.810.810.
Full textChen, Hong-Ru, Guan-Ting Lin, Chun-Kai Huang, and Ming-Ji Fann. "Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression." Experimental Neurology 261 (November 2014): 10–21. http://dx.doi.org/10.1016/j.expneurol.2014.06.024.
Full textKapasi, Anokhi J., and Deborah H. Spector. "Inhibition of the Cyclin-Dependent Kinases at the Beginning of Human Cytomegalovirus Infection Specifically Alters the Levels and Localization of the RNA Polymerase II Carboxyl-Terminal Domain Kinases cdk9 and cdk7 at the Viral Transcriptosome." Journal of Virology 82, no. 1 (October 17, 2007): 394–407. http://dx.doi.org/10.1128/jvi.01681-07.
Full texthu, Shan, David Moebius, Wojciech Dworakowski, Elliott Cooper, Derek LaPlaca, Sydney Alnemy, Phone Perera, et al. "Abstract 5393: An oral and selective CDK12 inhibitor demonstrates robust anti-tumor activity." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5393. http://dx.doi.org/10.1158/1538-7445.am2022-5393.
Full textKolloch, Lina, Teresa Kreinest, Michael Meisterernst, and Andrea Oeckinghaus. "Control of Expression of Key Cell Cycle Enzymes Drives Cell Line-Specific Functions of CDK7 in Human PDAC Cells." International Journal of Molecular Sciences 23, no. 2 (January 12, 2022): 812. http://dx.doi.org/10.3390/ijms23020812.
Full textStern, Yaakov E., Pompom Ghosh, Hannah L. Walker-Mimms, John W. Mosior, Denis Imbody, Hitendra S. Solanki, Andrii Monastyrskyi, Derek R. Duckett, and Eric B. Haura. "Abstract B028: CDK12/13 inhibition antagonizes resistance to KRASG12C inhibitors." Cancer Research 82, no. 23_Supplement_2 (December 1, 2022): B028. http://dx.doi.org/10.1158/1538-7445.cancepi22-b028.
Full textOgi, Sayaka, Yasuhiro Aga, Kazuhiro Onuma, Hidetoshi Sunamoto, Takashi Matsushita, Ayumi Ogawa, Tohru Hasegawa, et al. "Preclinical in vitro and in vivo evaluation of antitumor activity of UD-017, a novel selective and orally available CDK7 inhibitor, in colorectal cancer." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e14085-e14085. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e14085.
Full textDu, Jianhai, Na Wei, Tongju Guan, Hao Xu, Jianzhong An, Kirkwood A. Pritchard, and Yang Shi. "Inhibition of CDKS by roscovitine suppressed LPS-induced ·NO production through inhibiting NFκB activation and BH4 biosynthesis in macrophages." American Journal of Physiology-Cell Physiology 297, no. 3 (September 2009): C742—C749. http://dx.doi.org/10.1152/ajpcell.00138.2009.
Full textYamakawa, Hiroko, Akio Mizutani, Yasuyoshi Arikawa, Shunsuke Ebara, Yoshihiko Satoh, and Daisuke Morishita. "Abstract 5485: Discovery and preclinical evaluation of a novel highly selective and potent CDK12 inhibitor." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5485. http://dx.doi.org/10.1158/1538-7445.am2022-5485.
Full textYao, Yao, Woojun D. Park, Eugenio Morelli, Mehmet Kemal Samur, Nicholas P. Kwiatkowski, Yan Xu, Chandraditya Chakraborty, et al. "Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition." Blood 136, Supplement 1 (November 5, 2020): 1–2. http://dx.doi.org/10.1182/blood-2020-142592.
Full textLi, Ji, Porter, Broude, Roninson, and Chen. "Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay." Cells 8, no. 10 (October 6, 2019): 1208. http://dx.doi.org/10.3390/cells8101208.
Full textJohannessen, Liv, Nan Ke, Priyanka Sawant, Wojciech Dworakowski, Anthony D'Ippolito, Shanhu Hu, Nisha Rajagopal, Matthew Eaton, and Graeme Hodgson. "Activity of SY-5609, an oral, noncovalent, potent, and selective CDK7 inhibitor, in preclinical models of colorectal cancer." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 3585. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3585.
Full textLi, Tao-Sheng, Kimikazu Hamano, Masahiko Nishida, Masanori Hayashi, Hiroshi Ito, Akihito Mikamo, and Masunori Matsuzaki. "CD117+ stem cells play a key role in therapeutic angiogenesis induced by bone marrow cell implantation." American Journal of Physiology-Heart and Circulatory Physiology 285, no. 3 (September 2003): H931—H937. http://dx.doi.org/10.1152/ajpheart.01146.2002.
Full textTaylor, Mary Love, Hiba I. Dada, Hannah Florian, Paul Kelly Marcom, Carey K. Anders, Leylah Drusbosky, and Jeremy Meyer Force. "Identification of pathogenic CDK12 alterations in cell-free DNA (cfDNA) from patients with breast cancer." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 1028. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1028.
Full textPark, Shin Young, Ki Yun Kim, Do Youn Jun, Su-Kyeong Hwang, and Young Ho Kim. "G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181." Cancers 12, no. 12 (December 19, 2020): 3845. http://dx.doi.org/10.3390/cancers12123845.
Full textHupe, Marie C., Anne Offermann, Finn Becker, Vincent Joerg, Wenzel Vogel, Johannes Braegelmann, Sven Perner, and Axel Stuart Merseburger. "Targeting mediator subunits CDK8/CDK19 for treatment of advanced prostate cancer." Journal of Clinical Oncology 37, no. 7_suppl (March 1, 2019): 152. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.152.
Full textGramatzki, D., T. Weiss, L. Hänsch, M. Silginer, E. J. Rushing, P. Roth, M. Gramatzki, M. Peipp, and M. Weller. "P10.19.B An immunotoxin targeting CD317 for the treatment of glioblastoma." Neuro-Oncology 24, Supplement_2 (September 1, 2022): ii53. http://dx.doi.org/10.1093/neuonc/noac174.184.
Full textTsoi, Helen, Kwong-Fai Wong, John M. Luk, and Don Staunton. "Clinical utility of CDH17 biomarker in tumor tissues and liquid biopsies for detection and prognostic staging of colorectal cancer (CRC)." Journal of Global Oncology 5, suppl (October 7, 2019): 53. http://dx.doi.org/10.1200/jgo.2019.5.suppl.53.
Full textCain, Chris. "Selecting CDK7." Science-Business eXchange 7, no. 28 (July 2014): 817. http://dx.doi.org/10.1038/scibx.2014.817.
Full textZhang, Guizhong, Jian Cheng, Zhao Liu, Tian Deng, Funmilayo Oladunni Adeshakin, and Xiaochun Wan. "CD317-mediated cell cytoskeleton regulation as a novel means of tumor immune evasion." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 242.43. http://dx.doi.org/10.4049/jimmunol.204.supp.242.43.
Full textPeng, Fang, Chuansheng Yang, Yanan Kong, Xiaojia Huang, Yanyu Chen, Yangfan Zhou, Xinhua Xie, and Peng Liu. "CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β -catenin Signaling." Current Cancer Drug Targets 20, no. 2 (February 11, 2020): 156–65. http://dx.doi.org/10.2174/1568009619666191118113220.
Full textLarochelle, Stéphane, Karl A. Merrick, Marie-Emilie Terret, Lara Wohlbold, Nora M. Barboza, Chao Zhang, Kevan M. Shokat, Prasad V. Jallepalli, and Robert P. Fisher. "Requirements for Cdk7 in the Assembly of Cdk1/Cyclin B and Activation of Cdk2 Revealed by Chemical Genetics in Human Cells." Molecular Cell 25, no. 6 (March 2007): 839–50. http://dx.doi.org/10.1016/j.molcel.2007.02.003.
Full textHänsch, L., M. Peipp, R. Myburgh, M. Silginer, T. Weiss, D. Gramatzki, F. Vasella, M. Manz, M. Weller, and P. Roth. "PL03.3.A Development and characterization of CD317-specific CAR T cells as an innovative immunotherapeutic strategy against glioblastoma." Neuro-Oncology 23, Supplement_2 (September 1, 2021): ii2. http://dx.doi.org/10.1093/neuonc/noab180.005.
Full textTun, Nay Min, and Gina M. Villani. "Predictive value of KIT immunohistochemical staining for KIT mutations in patients with gastrointestinal stromal tumors (GIST): A systematic review." Journal of Clinical Oncology 30, no. 4_suppl (February 1, 2012): 30. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.30.
Full textYang, Bikang, Jing Chen, and Yincheng Teng. "CDK12 Promotes Cervical Cancer Progression through Enhancing Macrophage Infiltration." Journal of Immunology Research 2021 (February 11, 2021): 1–14. http://dx.doi.org/10.1155/2021/6645885.
Full textYang, L. L., L. Wu, G. T. Yu, W. F. Zhang, B. Liu, and Z. J. Sun. "CD317 Signature in Head and Neck Cancer Indicates Poor Prognosis." Journal of Dental Research 97, no. 7 (February 27, 2018): 787–94. http://dx.doi.org/10.1177/0022034518758604.
Full textGramatzki, Dorothee, Emese Szabo, Martin Gramatzki, Matthias Peipp, and Michael Weller. "Targeting of CD317 by the immunotoxin HM1.24-ETA’ to allow immunotherapy in glioblastoma patients." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e13560-e13560. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e13560.
Full textLi, Juan, Shaokai Luo, Guocai Zhang, Wende Hong, and Xiuzhen Tong. "Expression of the CD117 Antigen on Multiple Myeloma and Its Significance." Blood 104, no. 11 (November 16, 2004): 4867. http://dx.doi.org/10.1182/blood.v104.11.4867.4867.
Full textZhou, Jun, Xiaoqun Yang, Luting Zhou, Peipei Zhang, and Chaofu Wang. "Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution." Disease Markers 2019 (October 13, 2019): 1–9. http://dx.doi.org/10.1155/2019/4708154.
Full textGoh, Kee C., Wai C. Ong, Changyong Hu, Ai L. Liang, Walter Stunkel, Yong C. Tan, Kanda Sangthongpitag, et al. "SB1317, a Potent and Orally Active FLT3-CDK Inhibitor with High Anti-Tumor Efficacy in Models of Hematological Malignancies." Blood 110, no. 11 (November 16, 2007): 1593. http://dx.doi.org/10.1182/blood.v110.11.1593.1593.
Full textChalfant, Victor, Carlos Riveros, Sanjeev Shukla, Teruko Osumi, and K. Balaji. "Abstract 1622: Signaling of cyclin-dependent kinase 12 (CDK12) in prostate cancer cell lines." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1622. http://dx.doi.org/10.1158/1538-7445.am2022-1622.
Full textFujiwara, Kentaro, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Hiroki Akiba, Hiroko Iwanari, Osamu Kusano-Arai, et al. "111In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis." Annals of Nuclear Medicine 34, no. 1 (October 12, 2019): 13–23. http://dx.doi.org/10.1007/s12149-019-01408-y.
Full textAhmed, Rehana L., Daniel P. Shaughnessy, Todd P. Knutson, Rachel I. Vogel, Khalil Ahmed, Betsy T. Kren, and Janeen H. Trembley. "CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells." Pharmaceuticals 12, no. 2 (April 2, 2019): 50. http://dx.doi.org/10.3390/ph12020050.
Full textWang, Dong, Bethany Veo, Angela Pierce, Sujatha Venkataraman, and Rajeev Vibhakar. "MEDB-81. Combined inhibition of CDK11 and EZH2 results in regression of MYC-amplified medulloblastoma." Neuro-Oncology 24, Supplement_1 (June 1, 2022): i125. http://dx.doi.org/10.1093/neuonc/noac079.455.
Full textВалова, Я. В., Э. Ф. Муллагалеева, Э. Т. Мингажева, Д. С. Прокофьева, А. Х. Нургалиева, Р. Р. Фаисханова, and Э. К. Хуснутдинова. "Screening for a variant of the splicing site in the CDK12 gene in patients with ovarian cancer." Nauchno-prakticheskii zhurnal «Medicinskaia genetika», no. 6(215) (June 29, 2020): 42–43. http://dx.doi.org/10.25557/2073-7998.2020.06.42-43.
Full textHupe, Marie C., Anne Offermann, Cleopatra Schreiber, Axel Stuart Merseburger, and Sven Perner. "CDK12 upregulation and adverse correlation with tumor-associated immune cell infiltrates in prostate cancer." Journal of Clinical Oncology 38, no. 6_suppl (February 20, 2020): 181. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.181.
Full textAlfaleh, Mohamed, Neetika Arora, Michael Yeh, Christopher de Bakker, Christopher Howard, Philip Macpherson, Rachel Allavena, et al. "Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning." Antibodies 8, no. 1 (February 12, 2019): 15. http://dx.doi.org/10.3390/antib8010015.
Full textLudwig, Marion, Anita Tölk, Anna Skorska, Christian Maschmeier, Ralf Gaebel, Cornelia Aquilina Lux, Gustav Steinhoff, and Robert David. "Exploiting AT2R to Improve CD117 Stem Cell Function In Vitro and In Vivo - Perspectives for Cardiac Stem Cell Therapy." Cellular Physiology and Biochemistry 37, no. 1 (2015): 77–93. http://dx.doi.org/10.1159/000430335.
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