Academic literature on the topic 'CD8+CD38+'
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Journal articles on the topic "CD8+CD38+"
Mocroft, A., M. Bofill, M. Lipman, E. Medina, N. Borthwick, A. Timms, L. Batista, et al. "CD8+, CD38+ Lymphocyte Percent." Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 14, no. 2 (February 1997): 158–62. http://dx.doi.org/10.1097/00042560-199702010-00009.
Full textPetrovas, Constantinos, Yvonne M. Mueller, Ioannis D. Dimitriou, Susan R. Altork, Anupam Banerjee, Peter Sklar, Karam C. Mounzer, John D. Altman, and Peter D. Katsikis. "Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells." Blood 109, no. 6 (November 9, 2006): 2505–13. http://dx.doi.org/10.1182/blood-2006-05-021626.
Full textAlvarez-Jimenez, Violeta, Jeanet Serafin-Lopez, Sergio Estrada-Parra, Iris Elvira Estrada-García, and Claudia Sandoval-Montes. "Analysis of extrinsic pathway mediators in CD8+CD38+ T cells of healthy donors stimulated with Mycobacterium tuberculosis antigens (99.20)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 99.20. http://dx.doi.org/10.4049/jimmunol.186.supp.99.20.
Full textHo, H. N., L. E. Hultin, R. T. Mitsuyasu, J. L. Matud, M. A. Hausner, D. Bockstoce, C. C. Chou, S. O'Rourke, J. M. Taylor, and J. V. Giorgi. "Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens." Journal of Immunology 150, no. 7 (April 1, 1993): 3070–79. http://dx.doi.org/10.4049/jimmunol.150.7.3070.
Full textRíos-Olivares, Eddy, José W. Rodríguez, Luis A. Rodríguez, Madhavan Nair, and Robert Hunter. "Co-expression of apoptosis-related molecules on activated CD8+CD38+ T-cells is associated with HIV-1 disease progression (B213)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): LB44. http://dx.doi.org/10.4049/jimmunol.178.supp.b213.
Full textCaselli, D., G. Comolli, A. Maccabruni, C. Klersy, and L. Minoli. "CD38/CD8 expression and HAART failure." Lancet 353, no. 9155 (March 1999): 840–41. http://dx.doi.org/10.1016/s0140-6736(05)76500-4.
Full textOstendorf, L., P. Garantziotis, D. L. Wagner, P. Durek, F. Heinrich, P. Enghard, G. R. Burmester, et al. "POS0010 CD38+ MEMORY T CELLS ARE A FUNCTIONALLY DISTINCT SUBSET THAT IS EXPANDED IN SLE AND ASSOCIATED WITH LUPUS NEPHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 207.1–207. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3104.
Full textTincati, Camilla, Giusi M. Bellistrì, Giuseppe Ancona, Esther Merlini, Antonella d’Arminio Monforte, and Giulia Marchetti. "Role ofIn VitroStimulation with Lipopolysaccharide on T-Cell Activation in HIV-Infected Antiretroviral-Treated Patients." Clinical and Developmental Immunology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/935425.
Full textBai, Francesca, Camilla Tincati, Esther Merlini, Carlotta Pacioni, Elisabetta Sinigaglia, Giovanni Carpani, Antonella d’Arminio Monforte, and Giulia Marchetti. "Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection." AIDS Research and Treatment 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/314849.
Full textLawrence Cheung, Chun Chau, Yong Hock Justin Seah, Juntao Fang, Nicole Orpilla, Justina Nadia Li Wen Lee, Han Chong Toh, Su Pin Choo, Kiat Hon Lim, Wai Meng David Tai, and Joe Yeong. "89 The immune marker LAG-3 increases the predictive value of CD38+ immune cells for survival outcome in immunotherapy-treated hepatocellular carcinoma." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A97—A98. http://dx.doi.org/10.1136/jitc-2021-sitc2021.089.
Full textDissertations / Theses on the topic "CD8+CD38+"
Jiang, Janina Q. "The production of HIV suppressive factors by CD28, CD38 and HLA-DR subpopulations of CD8+ T cells." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9104.
Full textTorrealba, Marina Passos. "Caracterização fenotípica e funcional de linfócitos TCD8+ circulantes na síndrome de Sézary." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-07122016-145539/.
Full textINTRODUCTION: Sézary syndrome (SS) is a cutaneous T cell lymphoma (CTCL), characterized by erythroderma, generalized lymphadenopathy and the presence of tumor cells in the skin, lymph nodes and peripheral blood. The TCD8+ lymphocytes play a key role in anti-tumor immune response, whereas, there are few studies showing its phenotypic and functional profile in SS. Considering that the immune response of SS patient is suppressed, strategies to enhancing the innate and adaptive immunity by Toll-like receptors (TLRs) agonists have been explored. OBJECTIVE: To characterize the profile of activation/inhibition markers of CD8+ T cells, their stages of differentiation, ability of response to IL-7/IL-15 and TLR7/TLR8 agonist of patients with SS. METHODOLOGY: Fifteen SS patients were enrolled (7 men and 8 woman) with 48-85 years from the Clinic of Cutaneous Lymphomas, HC-FMUSP, and a control group of 24 healthy individuals. Analysis of activation/inhibition markers and cellular differentiation in CD4/CD8 T cells from peripheral blood were assessed by flow cytometry. The expression of extracellular markers and intracellular cytokines in mononuclear cells in the peripheral blood (CMN) were evaluated by flow cytometry. Moreover, the effect of IL-7 and IL-15 stimulation in T cells was assessed by the STAT5 phosphorylation, proliferative mitogenic capacity, BCL-2 expression in CMNs as well as serum IL-7 levels by flow cytometry. RESULTS: Patients with SS show a phenotypic CD8 T peripheral lymphocytes profile of chronic activation, due to the high percentage of CD8+CD38+ T cells, reduced percentage of CD8+CD127+ (IL-7R) and naïve population. Furthermore, it was observed an increased PD-1 expression in the naïve CD8+ T cells. The activation marker CD26, previously only associated with CD4 T lymphocyte, was detected at decreased percentage in CD8 T lymphocytes. The TLR7/TLR8 agonist did not affect the IFN-? and TNF secretion of CD8 T lymphocytes of SS patients, in contrast to the control group. The response to IL-7/IL-15 appears to be functional in both CD4 and CD8 T lymphocytes. However, it was founded a differentiated and heterogeneous profile of STAT5 phosphorylation and Bcl-2 expression in the CD8 T lymphocytes in SS patients. The reduced IL-7 serum of patients with SS was inversely correlated with the absolute number of CD4 T lymphocytes. CONCLUSION: CD8 T lymphocytes of patients with SS are reduced in absolute numbers, and show an altered cellular differentiation profile and extracellular markers expression. The reduced percentage of CD8 naïve population associated with chronic activation of molecules reveals an immunosenescence profile. The CD8 T cells exhibit low ability to ligands of intracellular TLR receptors, probably due to chronic activation profile. In addition, there are partial response of CD8 T lymphocytes to the cytokine receptor ?c. Our results show disturbance in CD8 T lymphocytes that may impair the anti-tumor response contributing to the pathogenesis of Sézary syndrome
Lino, Vania Abadia Soares. "Quantificação de células T CD8+ CD38+ por citometria de fluxopara detecção de infecção/reativação de citomegalovírus em pacientes submetidos ao transplante de Células-Tronco Hematopoiéticas." Universidade Federal de Minas Gerais, 2011. http://hdl.handle.net/1843/BUOS-8GYLNE.
Full textIntrodução: A infecção/reativação por citomegalovírus (CMV) é uma das principais causas de morbi/mortalidade em pacientes imunossuprimidos. Já foi observado em pacientes transplantados de rim e fígado, que este processo é acompanhado de aumento significativo de linfócitos T CD8+CD38+ circulantes. Em pacientes que receberam Transplante de Células Tronco-Hematopoiéticas (TCTH) não há relatos que abordem o estudo desta subpopulação na vigilância/diagnóstico da doença por CMV. Objetivos: Este estudo pretendeu avaliar marcadores de ativação celular em linfócitos T circulantes (CD38 e HLA-DR), por citometria de fluxo, em pacientes submetidos ao TCTH e sua correlação com a infecção/reativação por CMV. Métodos: Amostras de sangue de 15 pacientes submetidos ao TCTH foram analisadas, por citometria de fluxo, utilizando os anticorpos monoclonais anti-CD3, anti-CD4, anti-CD8, anti-CD38, anti-HLADR e os resultados comparados com a antigenemia para CMV, realizada por imunofluorescência indireta. Utilizou-se o programa Minitab for Windows para as análises estatísticas e o valor de p < 0,05 foi considerado como significante. Resultados: Os pacientes com antigenemia positiva não apresentaram aumento significativo nos percentuais de linfócitos TCD8+ expressando os marcadores de ativação celular CD38 e HLADR, quando comparados com os pacientes com antigenemia negativa. Surpreendentemente, observou-se que ambos os grupos apresentaram percentuais extremamente elevados de linfócitos ativados, independente da presença de doença por CMV. Conclusão Este estudo sugere que, em pacientes submetidos ao TCTH, o estudo de sub-populações linfocitárias circulantes ativadas não parece contribuir para a identificação precoce da doença por CMV.
Uglietti, A. "FATTORI PREDITTIVI DI RISPOSTA VIROLOGICA SOSTENUTA IN PAZIENTI CON COINFEZIONE HIV-HCV TRATTATI CON PEG-INTERFERONE E RIBAVIRINA." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/245615.
Full textChang, Shu ting, and 張舒婷. "To investigate the role of CD38+HLADR+CD8+ T cells in the chronic hepatitis C patients." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/06120064164657479804.
Full text長庚大學
生物醫學研究所
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Hepatitis C virus (HCV) is a common cause of liver disease worldwide. The persistent infection of HCV is associated with impaired CD8 T cell function. Chronic infection can lead to fibrosis of the liver and ultimately to cirrhosis, which is generally apparent after decades. In some cases, those with cirrhosis will go on to develop liver cancer even die. Human leukocyte antigen-DR (HLA-DR) and CD38 are expressed by activated T cells during the acute phase of viral infections in humans. Previous studied indicated that the populations of CD38+HLADR+CD8+ T cells were increased when infected with Human Immunodeficiency Virus, Epstein–Barr virus and Hepatitis B virus. However, the role of CD38+HLADR+CD8+ T cells during chronic HCV infection is poor described and their function has not been studied yet. In my study, results showed that the percentage of CD38+HLADR+CD8+ T cells in peripheral blood of chronic HCV patients was significantly increased when compared with healthy volunteer. The CD38+HLADR+CD8+ T cells have increased expression of cytotoxitc molecules but also with higher levels of inhibitory receptor than CD38-HLADR-CD8+ T cells. In addition, results showed these cells would accumulate in the inflamed liver. Results indicated that the both HCV specific and non-HCV-specific CD8+ T cells contributed to the increase of CD38+HLADR+CD8+ T cells in patients with chronic hepatitis C. Moreover, the CD38+HLADR+CD8+ T cells would behave as innate CD8+ T cells and produce IFN-γ by cytokine-dependent pathway. Taken together, we suggest that during chronic HCV infection, these CD38+HLADR+CD8+ T cells, both HCV-specific and non-HCV specific, were increased and accumulated in the liver. Their role in the chronic hepatitis C needs to be elicited in the subsequent studies.
Blaich, Henning. "CD38 Expression auf CD8+ T-Lymphozyten als Marker der Immunaktivierung bei HIV infizierten Patienten unter antiretroviraler Therapie /." 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014802142&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textBartovská, Zofia. "Vybrané aspekty imunopatogeneze HIV infekce." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-311627.
Full textBook chapters on the topic "CD8+CD38+"
Vigano, A., M. Saresella, M. L. Villa, P. Ferrante, and M. Clerici. "CD38+CD8+ T Cells as a Marker of Poor Response to Therapy in HIV-Infected Individuals." In Human CD38 and Related Molecules, 207–17. Basel: KARGER, 2000. http://dx.doi.org/10.1159/000058770.
Full textLapietra, Gianfranco, Francesca Fazio, and Maria Teresa Petrucci. "The Modern Age of Monoclonal Antibodies: The Revolution of Daratumumab." In Multiple Myeloma [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95406.
Full textConference papers on the topic "CD8+CD38+"
Chen, Limo, Lixia Diao, Yongbin Yang, Xiaohui Yi, Jaime Rodriguez, Youhong Fan, Leticia Rodriguez, et al. "Abstract 567: CD38 blockade overcomes the immune resistance to anti-PD-L1 therapy by boosting CD8 T cell response." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-567.
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