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Hou, Zhengmeng, Jiashun Luo, Yachen Xie, Lin Wu, Liangchao Huang, and Ying Xiong. "Carbon Circular Utilization and Partially Geological Sequestration: Potentialities, Challenges, and Trends." Energies 16, no. 1 (December 28, 2022): 324. http://dx.doi.org/10.3390/en16010324.
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Enhancing carbon emission mitigation and carbon utilization have become necessary for the world to respond to climate change caused by the increase of greenhouse gas concentrations. As a result, carbon capture, utilization, and storage (CCUS) technologies have attracted considerable attention worldwide, especially in China, which plans to achieve a carbon peak before 2030 and carbon neutrality before 2060. This paper proposed six priorities for China, the current world’s largest carbon emitter, to achieve its dual carbon strategy in the green energy transition process. We analyzed and summarized the challenges and potentialities of conventional carbon utilization (CU), carbon capture utilization (CCU), and CCUS. Based on the current development trend, carbon dioxide capture, circular utilization, and storage (CCCUS) technology that integrates carbon circular utilization and partial sequestration, with large-scale underground energy storage were proposed, namely biomethanation. Technically and economically, biomethanation was believed to have an essential contribution to China’s renewable energy utilization and storage, as well as the carbon circular economy. The preliminary investigation reveals significant potential, with a corresponding carbon storage capacity of 5.94 × 108 t~7.98 × 108 t and energy storage of 3.29 × 1012 kWh~4.42 × 1012 kWh. Therefore, we believe that in addition to vigorously developing classical CCUS technology, technical research and pilot projects of CCCUS technology that combined large-scale underground energy storage also need to be carried out to complete the technical reserve and the dual-carbon target.
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Malcovati, L. "CCUS: CLINICAL PERSPECTIVE (HIGH-RISK CCUS)." Leukemia Research 128 (May 2023): 107087. http://dx.doi.org/10.1016/j.leukres.2023.107087.
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Mon, Min Thura, Roengchai Tansuchat, and Woraphon Yamaka. "CCUS Technology and Carbon Emissions: Evidence from the United States." Energies 17, no. 7 (April 5, 2024): 1748. http://dx.doi.org/10.3390/en17071748.
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Carbon Capture, Utilization, and Storage (CCUS) represents a vital technology for addressing pressing global challenges such as climate change and carbon emissions. This research aims to explore the relationship between the CCUS capability and carbon emissions in the United States considering thirteen predictors of CCUS and carbon emissions. Incorporating these predictors, we aim to offer policymakers insights to enhance CCUS capabilities and reduce carbon emissions. We utilize diverse econometric techniques: OLS, Lasso, Ridge, Elastic Net, Generalized Method of Moments, and Seemingly Unrelated Regression. Elastic Net outperforms the other models in explaining CCUS, while OLS is effective for carbon emissions. We observe positive impacts of the number of projects and foreign direct investment on the CCUS capacity, but limited influence from the CCUS technology level. However, the relationship between the CCUS capacity and carbon emissions remains limited. Our study highlights the importance of incentivizing projects to increase CCUS capabilities and recognizes the critical role of legal and regulatory frameworks in facilitating effective CCUS implementation in the US. Moreover, we emphasize that achieving decarbonization goals necessitates the development of affordable green alternatives. It is essential to view CCUS as a complementary, rather than a sole, solution for emission reduction as we work towards achieving net-zero emission targets.
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Song, Dongdong, Tong Jiang, and Chuanping Rao. "Review of Policy Framework for the Development of Carbon Capture, Utilization and Storage in China." International Journal of Environmental Research and Public Health 19, no. 24 (December 15, 2022): 16853. http://dx.doi.org/10.3390/ijerph192416853.
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Carbon capture, utilization and storage (CCUS) has been applied in many countries and has proven to be a key carbon-reduction technology for the future. China currently emits the most carbon, and prior research findings indicate the high potential of CCUS technology to support the country’s emission-reduction process. China introduced CCUS technology at the end of the 20th century and has since implemented a series of related policies. This paper compares the development status of CCUS in China and other countries, studies the legal and policy framework and the development process of CCUS in China, and analyzes the defects in relevant laws and policies. The results show that China’s current legal and policy system is not conducive to the further development of CCUS; specifically, there is no special law, and the policy system is incomplete. Consequently, it is difficult to advance and give full play to the emission-reduction effect of CCUS. To promote CCUS development in China, this paper proposes corresponding countermeasures, including formulating a special law, perfecting the CCUS policy system, expanding government financial support, and improving CCUS public awareness and support.
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Kabir, Md Ainul, Sharfuddin Ahmed Khan, and Golam Kabir. "Carbon Capture, Utilization, and Storage Risks from Supply Chain Perspective: A Review of the Literature and Conceptual Framework Development." C 10, no. 1 (January 31, 2024): 15. http://dx.doi.org/10.3390/c10010015.
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The technology called carbon capture, utilization, and storage (CCUS) is important for capturing CO2 emissions before they enter the air. Because everyone wants to stop global warming by reducing CO2 emissions, CCUS is an important and emerging technology that can help slow down climate change, lower emissions in many areas, and support the move toward a sustainable and carbon-neutral future. As CCUS technology and its adaptation increases, it is very important to pay attention to the CCUS risks from a supply chain (SC) point of view. The goal of this study was to identify CCUS supply chain risks and develop a conceptual framework (CF) that provides a structured approach to ensure safe and reliable CCUS supply chain operations. Therefore, this study analyzed the literature related to the SCs of different sectors and identified the SC risks, which was the foundation for CCUS SC risk identification. This study demonstrates that there is no research article that provides a comprehensive CCUS SC risk management framework that connects with risk management strategies. The conceptual framework that is proposed in this study connects CCUS SC functions, risks, and risk management strategies to construct a complete CCUS supply chain risk management system. Moreover, the CF provides guidelines for future research, which will enrich the CCUS supply chain risk management system as well as fight climate change.
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Adelman, Mark, Himanshu Deshwal, and Deepak Pradhan. "Critical Care Ultrasound Competency of Fellows and Faculty in Pulmonary and Critical Care Medicine: A Nationwide Survey." POCUS Journal 8, no. 2 (November 27, 2023): 202–11. http://dx.doi.org/10.24908/pocus.v8i2.16640.
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Purpose: Competency assessment standards for Critical Care Ultrasonography (CCUS) for Graduate Medical Education (GME) trainees in pulmonary/critical care medicine (PCCM) fellowship programs are lacking. We sought to answer the following research questions: How are PCCM fellows and teaching faculty assessed for CCUS competency? Which CCUS teaching methods are perceived as most effective by program directors (PDs) and fellows. Methods: Cross-sectional, nationwide, electronic survey of PCCM PDs and fellows in accredited GME training programs. Results: PDs and fellows both reported the highest rates of fellow competence to use CCUS for invasive procedural guidance, but lower rates for assessment of deep vein thrombosis and abdominal organs. 54% and 90% of PDs reported never assessing fellows or teaching faculty for CCUS competency, respectively. PDs and fellows perceived hands-on workshops and directly supervised CCUS exams as more effective learning methods than unsupervised CCUS archival with subsequent review and self-directed learning. Conclusions: There is substantial variation in CCUS competency assessment among PCCM fellows and teaching faculty nationwide. The majority of training programs do not formally assess fellows or teaching faculty for CCUS competence. Guidelines are needed to formulate standardized competency assessment tools for PCCM fellowship programs.
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Træden, Dicte, Morten Tulstrup, Morten Munk Johansen, Andreas Due Ørskov, Claus Marcher, Klas Raaschou-Jensen, Anne Stidsholt Roug, et al. "Overall Survival in Patients with Ccus Depends on Presence of Anemia." Blood 142, Supplement 1 (November 28, 2023): 1864. http://dx.doi.org/10.1182/blood-2023-177879.
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Introduction Clonal cytopenia of undetermined significance (CCUS) is a recently recognized hematological disorder characterized by the presence of one or more cytopenias, evidence of clonal hematopoiesis and not fulfilling the criteria for a myeloid neoplasm. In contrast to myelodysplastic syndromes (MDS) where 95% of the patients are anemic at time of diagnosis, that is only the case for around 60% of patients with CCUS (Weeks et al. Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis. NEJM Evid. 2023). Furthermore, as recent studies on survival in CCUS primarily included younger patients (Weeks et al. NEJM Evid. 2023) or population-based cohorts not specifically referred for diagnostic work up of unexplained cytopenia (UC) (Rossi et al. Clinical relevance of clonal hematopoiesis in persons aged ≥80 years, Blood 2021) additional survival data on patients with CCUS are warranted. In this study, we investigated survival outcomes in patients with CCUS referred for primary work up of UC. Methods We included 241 patients with CCUS and compared them to 144 patients with low-risk MDS, defined as having less than 5% blasts in the bone marrow. Bone marrow biopsies and next-generation sequencing (NGS) were performed in all patients and cytogenetic analyses using G-band karyotyping was done in 362 (94%) of cases. For NGS, we used a gene panel with the most commonly mutated genes in MDS. The patients were included at 6 different institutions in Denmark from 2013 and onwards. A cut-point of 5 years follow-up was chosen for more robust survival data, and patients were censored at this time point if followed for more than 5 years. Patients with CCUS were stratified into 3 groups dependent on the type of cytopenia present at diagnosis. CCUS patients with pancytopenia (n = 35), and CCUS patients without pancytopenia were split based on whether they were anemic (n = 143) or not (n =63). We compared overall survival between the CCUS groups and low-risk MDS in a Cox proportional hazards model adjusted for age, sex, number of variants and presence of high-risk variants. Results Of the 241 CCUS patients, 178 (74%) were anemic (hemoglobin < 12 and 13 g/dL for women and men, respectively), while this was the case for 130 (90%) of the patients with MDS. A total of 772 variants were identified in the entire cohort with a median of 2 (IQR: 1-3) per patient for both CCUS and MDS patients. The overall survival at 5 years was 45% for low-risk MDS patients and 62% for CCUS patients. For CCUS patients without anemia, CCUS patients with anemia and CCUS patients with pancytopenia overall survival at 5 years was 85%, 52% and 55%, respectively (p < 0.0001). In the adjusted Cox proportional hazards model, we found a significantly superior overall survival for CCUS patients without anemia compared to those with anemia (HR: 0.28, 95%-CI: 0.13-0.58, p = 0.001) and pancytopenia (HR: 0.22, 95%-CI: 0.09-0.53, p = 0.001) and patients with low-risk MDS (HR: 0.18, 95%-CI: 0.09-0.38, p < 0.001). There was no significant survival difference between CCUS patients with pancytopenia and low-risk MDS patients (HR: 0.67, 95%-CI: 0.46-1.50, p = 0.5). Of the remaining variables, age was the strongest prognostic factor with hazard ratio increasing with a factor 1.05 (95%-CI: 1.03-1.07, p < 0.001) per year aged. Predicted survival probabilities for a 65-year-old and 80-year-old person demonstrate a substantial difference in overall survival across all 3 categories of CCUS (figure 1). Discussion Here we show that the presence of anemia impacts overall survival among CCUS patients. We observe that CCUS patients without anemia, representing 26% of CCUS patients in our cohort, have a superior overall survival compared to those with anemia, even with a comparable mutational profile. Our findings indicate that other factors than mutational signatures impact overall survival. Moreover, the prevalence of CCUS increases with age, and our findings demonstrate a considerable difference in survival between a 65-year-old and 80-year-old person diagnosed with CCUS. This raises the concern that prediction models can overestimate the survival rates if the elderly group of CCUS patients is not well represented in these models. In conclusion, we show that age and hemoglobin levels are important factors in overall survival for CCUS patients, and that patients with CCUS without anemia have a superior overall survival and should be considered as a separate group within the CCUS category.
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Huang, Liangchao, Zhengmeng Hou, Yanli Fang, Jianhua Liu, and Tianle Shi. "Evolution of CCUS Technologies Using LDA Topic Model and Derwent Patent Data." Energies 16, no. 6 (March 8, 2023): 2556. http://dx.doi.org/10.3390/en16062556.
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Carbon capture, utilization, and storage (CCUS) technology is considered an effective way to reduce greenhouse gases, such as carbon dioxide (CO2), which is significant for achieving carbon neutrality. Based on Derwent patent data, this paper explored the technology topics in CCUS patents by using the latent Dirichlet allocation (LDA) topic model to analyze technology’s hot topics and content evolution. Furthermore, the logistic model was used to fit the patent volume of the key CCUS technologies and predict the maturity and development trends of the key CCUS technologies to provide a reference for the future development of CCUS technology. We found that CCUS technology patents are gradually transforming to the application level, with increases in emerging fields, such as computer science. The main R&D institutes in the United States, Europe, Japan, Korea, and other countries are enterprises, while in China they are universities and research institutes. Hydride production, biological carbon sequestration, dynamic monitoring, geological utilization, geological storage, and CO2 mineralization are the six key technologies of CCUS. In addition, technologies such as hydride production, biological carbon sequestration, and dynamic monitoring have good development prospects, such as CCUS being coupled with hydrogen production to regenerate synthetic methane and CCUS being coupled with biomass to build a dynamic monitoring and safety system.
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Huber, Sandra, Constance Regina Baer, Stephan Hutter, Gregor Hoermann, Christian Pohlkamp, Wencke Walter, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, and Claudia Haferlach. "Genomic Landscape of Ccus Compared to MDS Indicates a Potential Applicability of the IPSS-M." Blood 142, Supplement 1 (November 28, 2023): 4609. http://dx.doi.org/10.1182/blood-2023-177582.
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Background: The 5 th edition of the WHO classification newly included myeloid precursor lesions introducing CCUS as an entity. CCUS is defined as clonal hematopoiesis (CH) in the presence of unexplained, persistent cytopenia requiring detection of either somatic mutation in certain CH associated genes or clonal chromosomal abnormalities. Aim: Characterize a large CCUS cohort with respect to cytogenetics and molecular genetics and compare the findings to an MDS cohort to evaluate differences in the genomic landscape. Methods: The CCUS cohort comprised 222 cases (median age: 76 y; female: 33%), the MDS cohort 698 cases (median age: 73 y; female: 43%). The diagnoses were established following WHO 2022. All samples were analyzed by cytomorphology, cytogenetics, targeted NGS panel (median coverage 1500x) and whole genome (median coverage 100x) sequencing. Mutation (MUT) status of 59 genes associated with myeloid malignancies were analyzed in detail (54 CH associated; 5 relevant for IPSS-M). Results: Significant differences in age, gender, BM blasts, blood parameters and number and types of cytopenias were detected. CCUS patients (pts) were older, had more WBC, less PLT, harbored a higher HB, less BM blasts and were even more predominantly male compared to MDS pts (all p<0.05). Within the CCUS cohort 29 pts (13%) showed cytogenetic abnormalities (CA) only (thereof 69% loss of chromosome Y (Y-loss)), while the remaining 193 pts (87%) showed at least one MUT (VAF ≥2%) in any of the 54 CH associated genes (thereof 84% MUT only; 16% MUT+CA). Regarding cytogenetics 162 CCUS pts (73%) harbored normal karyotypes while CA were detected in 27% (MDS: 43%; p<0.001) with Y-loss being most frequent (39/60; 65%). Y-loss was more frequently found in CCUS than in MDS (17% vs. 5%; p<0.001), while complex karyotypes and del(5q) were more frequent in MDS (11% and 16% vs. 1% and 0%; both p<0.001). Based on WGS data additional pts with Y-loss (n=7; confirmed by FISH) and recurrent CN-LOH (4q: n=4; 7q: n=5) were observed. With respect to somatic MUTs, 356 MUTs were found within the entire CCUS cohort (in 28 CH genes, 3 non-CH genes). Overall, CCUS pts showed less MUTs (median: 1 [0-6]) compared to MDS (median: 2 [0-12]; p<0.001). CCUS pts most frequently harbored MUTs in DNMT3A (32%), TET2 (28%) and ASXL1 (14%) followed by MUTs in splicing genes and TP53 (Fig. 1A). MUTs in DNMT3A and PPM1D were more frequent in CCUS than MDS while MUTs in ASXL1, TP53, SF3B1, STAG2, RUNX1, NRAS, CUX1 were less frequent in CCUS (each p<0.05). Notably, biallelic TP53 MUTs were less frequent in CCUS compared to MDS ( TP53bi of mutated: 14% vs. 55% p=0.008). Within the 15 most frequently mutated genes in CCUS, MUTs in 6 genes ( DNMT3A, SF3B1, TP53, CBL, STAG2, PPM1D) showed a median VAF <10%. Nine of the top 15 genes showed significantly lower median VAFs than in MDS ( DNMT3A, TET2, ASXL1, SRSF2, U2AF1, SF3B1, TP53, PPM1D, IDH2; each p<0.05). Thus, the frequency and VAF of ASXL1, TP53, SF3B1 MUTs were significantly lower in CCUS than in MDS, while DNMT3A and PPM1D MUTs were significantly more often detected in CCUS but at a lower VAF than in MDS. Combining cytogenetics and mutational analysis we calculated the IPSS-M, a patient-specific risk score for MDS resulting in six risk categories, and detected a clear skewing towards low risk categories in CCUS (Fig. 1B). The frequency of categories very low (VL) and low (L) were significantly higher in CCUS than in MDS (30% vs. 15%; 50% vs. 40%; both p<0.013), while high and very high categories were more rare (1% vs. 13%; 1% vs. 14%; both p<0.001). Although CCUS follow-up data were short (median: 1.5 y), no differences in overall survival were observed between CCUS VL+L and MDS VL+L, while within CCUS survival differed between VL+L and the remaining cases ( p=0.05). Conclusions: Our data confirm the comparable mutational spectrum between CCUS and MDS but clearly show major differences in the frequency and VAF of distinct gene mutations. These biological differences hint towards different subgroups within CCUS with cases closer to MDS than others. A combined risk score for MDS and CCUS would reflect this continuous spectrum and has the potential to derive an objective risk assessment irrespective of observer-dependent grading of dysplasia. Our study indicates plausible short term results for CCUS patients stratified according to the IPSS-M. However, the definite applicability of the IPSS-M needs to be confirmed in larger CCUS studies with longer follow-up.
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Shah, Mithun V., Abhishek A. Mangaonkar, Kebede H. Begna, Hassan B. Alkhateeb, Patricia Greipp, Dong Chen, David S. Viswanatha, et al. "Therapy-Related Cytopenia of Undetermined Significance (t-CCUS) As a Precursor to Therapy-Related Myeloid Neoplasms (t-MN)." Blood 138, Supplement 1 (November 5, 2021): 1096. http://dx.doi.org/10.1182/blood-2021-145696.
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Abstract Background Clonal cytopenia of undetermined significance (CCUS) is a risk factor for development of myeloid neoplasms (MN) such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Therapy-related myeloid neoplasm (t-MN) is defined as the development of a MN in the context of prior DNA damaging therapies including chemotherapy, radiation, and immunosuppressive therapies. CCUS diagnosed in the setting of prior DNA damaging therapy (t-CCUS) and its outcomes are not known. The aim of this study was to study clinicopathological features and outcome of t-CCUS and compare it with t-MN. Methods Patients who had received DNA-damaging therapy and subsequently determined to have CCUS or t-MN were identified. The diagnosis of CCUS was made if the patient had non-diagnostic bone marrow biopsy evaluation combined with evidence of pathogenic myeloid somatic genetic alterations using conventional cytogenetics or next generation sequencing (NGS) panel. Pathogenic/likely pathogenic variants (PV) were stratified by DTA (DNMT3A, TET2, and ASXL1) genes vs. others. Event-free survival (EFS) was calculated using interval from t-CCUS to t-MN with death as a competing risk. Overall survival (OS) for t-CCUS and t-MN patients was calculated using interval from t-CCUS or t-MN diagnoses respectively to the last follow up. Statistical analysis was performed using JMP (v14.1, SAS Institute). Results We identified 30 patients with t-CCUS and 259 patients with t-MN. Eleven (37%) t-CCUS patients developed t-MN and were included in both cohorts (Fig. A). Clinical characteristics of t-CCUS patients are shown in Table 1. Briefly, age (median, interquartile range or IQR) at the diagnosis of primary malignancy and t-CCUS was not different between those who developed t-MN and those did not (P=0.09 and 0.378 respectively). There was no difference in hemoglobin, white blood cells, or ANC between the two groups. Patients who developed t-MN had a significantly lower platelet count (68 vs. 130, P<0.01) and higher bone marrow blast percent (2 vs. 0, P=0.04) compared to those who did not. At t-CCUS diagnosis, cytogenetics was abnormal in 11 (37%) patients and none had complex karyotype (CK). Paired cytogenetic analysis at t-CCUS and t-MN was available for 10 patients: 4 had unchanged karyotype at t-MN, whereas 6 had cytogenetic evolution. In contrast, 213 (83%) of 256 t-MN patients with available cytogenetics had abnormalities and 126/256 (49%) had CK. Thus, a significantly higher proportion of patients had CK t-MN compared to t-CCUS (χ 2 26.4, P<0.01). A 42-gene NGS panel identified 36 PV in 21 patients (median 1, range 1-4) at t-CCUS. The most common PV were in TET2 (37.1%), TP53 (11.4%), DNMT3A (8.6%), and ZRSR2 (8.6%) genes. Two patients had paired NGS available at t-CCUS and t-MN: one had BCOR and U2AF1 PV at t-CCUS and acquired an additional NRAS PV at t-MN. The second patient had 2 PV in TP53 at t-CCUS diagnosis, that remained the only PV identified at t-MN. In the t-MN cohort, median number of PV was 2 (range 1-9). The most common PV identified were TP53 (21.5%), TET2 (6.7%), DNMT3A (6.4%), and ASXL1 (6.4%), whereas 4.8% patients had no PV. Three of 22 patients in the t-CCUS cohort had TP53mut, compared to 55 of 157 in the t-MN cohort (χ 2 4, P=0.05). Management strategies for t-CCUS included observation (20), growth factors (4), treatment of primary malignancy (2), immunosuppressives (1), hypomethylating agent followed by allogeneic SCT (1), and others (2). Following t-CCUS, 9 patients progressed to MDS and 2 to AML with a median of 3.5 months (IQR 1.7-43.4). EFS was 43.4 months (IQR 6.8-80.9). The presence of abnormal cytogenetics (Fig. B) and the absence of DTA-mutations (Fig. C) predicted shorter EFS. At last follow up, 12 (40%) deaths were noted. Four (33%) patients died without developing t-MN. Causes of death in the t-CCUS cohort were: t-MN (3), primary malignancy (1), progressive cytopenia without MN (1), infection (1), graft-vs.-host-disease (1), and undetermined (5). t-MN patients had a significantly shorter survival compared to t-CCUS (Fig. D). Conclusion More than 10% of t-MN patients had a precursor t-CCUS. On the other hand, t-CCUS patients are at a high risk of progression to MN. t-MN is characterized by the acquisition of TP53mut, genomic instability, and a significantly shorter survival compared to t-CCUS. The presence of abnormal cytogenetics and the absence of DTA mutations at t-CCUS predict shorter EFS. Figure 1 Figure 1. Disclosures Litzow: Omeros: Other: Advisory Board; AbbVie: Research Funding; Jazz: Other: Advisory Board; Amgen: Research Funding; Astellas: Research Funding; Pluristem: Research Funding; Actinium: Research Funding; Biosight: Other: Data monitoring committee. Patnaik: Kura Oncology: Research Funding; Stemline Therapeutics: Membership on an entity's Board of Directors or advisory committees; Stemline Therapeutics: Membership on an entity's Board of Directors or advisory committees. Al-Kali: Novartis: Research Funding; Astex: Other: Research support to institution.
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Daunov, Michael, Howard Meyerson, Kwadwo Asare Oduro, Christopher B. Ryder, Navid Sadri, Jennifer Yoest, Shufen Cao, Pingfu Fu, Rose Beck, and Benjamin Tomlinson. "A Longitudinal Evaluation of Cytopenia Severity in Patients with Clonal Cytopenia of Undetermined Significance (CCUS) and Correlation with the Presence of Sub-Clinical Dysplasia." Blood 138, Supplement 1 (November 5, 2021): 3705. http://dx.doi.org/10.1182/blood-2021-153506.
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Abstract Introduction Clonal cytopenia of undetermined significance (CCUS) represents a clonal group of cells with the presence of a hematologic malignancy-associated somatic mutation without meeting the morphologic criteria for MDS. CCUS patients have a variable risk of progression to MDS. The WHO requires at least 10% of a cell lineage have dysplastic morphology for the diagnosis of MDS, but CCUS patients have been described with no evidence of dysplasia (CCUS-ND) or with low level dysplasia (CCUS-D). We previously identified CCUS-D as biologically distinct with higher risk MDS mutations. We hypothesized that CCUS-D would be independently associated with the risk of progressive cytopenia over time and thus may have clinical relevance in the setting of CCUS. Methods Cases of CCUS were identified on review of bone marrow biopsies completed for the diagnosis of cytopenia from 8/2016 to 9/2018 with results of a custom 31-gene NGS hotspot panel to detect mutations in the following genes: ASXL1, BRAF, CALR, CBL, CSF3R, DNMT3A, ETV6, EZH2, FLT3, GATA2, IDH1, IDH2, JAK2, JAK3, KIT, KRAS, MPL, MYD88, NPM1, NRAS, PHF6, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, TET2, TP53, U2AF1, WT1, and ZRSR2. The classification of CCUS-D or CCUS-ND required two or more board-certified hematopathologists to score the degree of morphologic dysplasia on bone marrow aspirates with at least one of the following morphologic criteria: >2%-<10% erythroid precursors with nuclear irregularities, >50% erythroid cells with megaloblastoid changes and/or basophilic stippling, >5%-<10% hypogranular and/or hypolobated granulocytes, or ≥10% megakaryocytes that were small and hypolobated or showed other nuclear abnormalities such as grape-like nuclei. We recorded baseline characteristics including cytogenetics, results of next-generation sequencing, and lab findings and then followed patients with annual blood counts. Statistical differences of baseline characteristics were evaluated by T-test for continuous variables, and Chi-square / Fisher's exact test were used for association between categorical variables. The repeated measures over time for various outcomes (WBC, ANC, hemoglobin, platelet) were visualized using scatter plot supervised with lowess smoother. The effects of dysplasia on various longitudinal outcomes were estimated using linear mixed-effect models. Results We identified 54 CCUS patients on review of 200 marrows completed for undiagnosed cytopenia. Twenty-six patients were identified with CCUS-D, and 28 patients with CCUS-ND. Baseline clinical characteristics including age, gender, race, smoking status, or presence of infection at time of initial diagnosis were similar. Hematology laboratory parameters including White Blood Cell Count (WBC), Absolute Neutrophil Count (ANC), Hemoglobin (Hgb), and Platelet Count (Plts) did not differ. (Table 1). Patients with CCUS-D had an average of 1.62 mutated genes detected per patient with the most common being TET2 (26.19%), SRSF2 (14.29%), and DNMT3A (14.29%). Patients with CCUS-ND had an average of 1.41 mutations per patient with the most common being TET2 (31.57%) and DNMT3A (31.57%). Patients were followed for a median of 32.2 months and a range from 1.0 to 48.8 months. On long term follow up, WBC, ANC, Hgb and plts trended lower in patients with CCUS-D compared to CCUS-ND, but the difference was marginally statistically significant (p = 0.09, 0.16, 0.13, 0.64 respectively). We also evaluated the rate of change in hematology parameters and found no significant difference in change rate of WBC, ANC, and hgb (p = 0.25, 0.13, and 0.28, respectively). There was a significant difference in the change rate of platelet counts between the two groups (p = 0.026). In particular, patients with CCUS-D had decreasing platelet counts at a rate of -0.04119 10E9/L/day and patients with CCUS-ND had increasing platelet counts at a rate of 0.01075 10E9/L/day. Two patients in the CCUS-D cohort progressed to MDS at an average of 938.5 days. One patient with CCUS-ND progressed to Large Granular Lymphocytic Leukemia at 805 days. Conclusions Low level (< 10%) dysplasia in cell lineages in CCUS is associated with a higher rate of decline in platelet counts but was not independently associated with increased risk of progressive neutropenia, leukopenia, or anemia. Longer follow up may be required to further understand the clinical significance of low level dysplasia in CCUS. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Shah, Syed Naseem, Marissa Li, Anmol Baranwal, Dong Chen, Rong He, Hassan B. Alkhateeb, Ayalew Tefferi, et al. "Outcome of TP53-mutated CCUS and the risk of progression to myeloid neoplasms." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): 7059. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.7059.
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7059 Background: TP53-mutated ( TP53mut) myeloid neoplasms (MN) are aggressive leukemia with poor survival. A subset of TP53mut MN is preceded by TP53mut CCUS that is conventionally considered to be high-risk premalignant condition, though evidence supporting the notion is lacking. We studied outcomes of TP53mut CCUS compared to TP53 wild-type ( TP53wt) CCUS. Methods: Mayo Clinic Molecular Hematology Database (N=7593) was queried to identify patients (pts) harboring pathogenic variant(s) in exons 4-11 of the TP53 gene with ≥2% variance allele frequency (VAF). CCUS was defined using the 5th edition of the WHO Classification for MN. Results: Of 457 pts with TP53mut, 29 (5.9%) had TP53mut CCUS. The median age at diagnosis was 67 years, 17 (59%) were female, and 20 (69%) had received cytotoxic therapies. One and ≥2 TP53mut were seen in 26 (89.6%) and 3 (10.3%) pts, respectively. Median TP53mut VAF was 9% (range 3-42), 3 had TP53mut VAF ≥20%, and 4 (14%) had non-MDS defining cytogenetic anomalies. Of 16 pts with available follow up evaluation (median interval 22 months, Table), 3 (10.3%) progressed to TP53mut MN at 5, 13, and 14 months from diagnosis. We next compared outcomes of TP53mut CCUS to TP53wt CCUS (n=138). The proportion of pts developing MN was not different between TP53wt and TP53mut CCUS (18.1 vs 10.3%, P= .42). Progression free survival of TP53mut CCUS was comparable to TP53wt CCUS at 1- (77 vs 83%), 2- (67 vs 67%), and 5-years (67 vs 59%, P=.9). Similarly, overall survival of TP53mut vs TP53wt CCUS at 1- (81 vs 89%), 2- (76 vs 76%), and 5-years (76 vs 67%) was comparable ( P= .94). Conclusions: In contrast to the prevalent notion, TP53mut was not associated with a higher risk of MN progression or mortality compared to TP53wt CCUS. Majority of TP53mut clones showed remarkable stability over years. [Table: see text]
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Yu, Jing, Bo Zhou, Pingliang Fang, Bing Li, Wenchao Sun, and Long Chang. "Research on the Development and Policy Evolution of CCUS Industry at Home and Abroad." International Journal of Environmental Protection and Policy 12, no. 3 (June 21, 2024): 64–72. http://dx.doi.org/10.11648/j.ijepp.20241203.12.
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CCUS is internationally recognized as one of the three major pathways to achieve carbon neutrality goals. It is an important choice for realizing zero emissions from large-scale fossil energy utilization and a feasible technological solution to offset carbon emissions in industries such as power, steel, and cement where emissions reductions are challenging. Systematic analysis of the development and policy evolution of the CCUS industry at home and abroad can provide theoretical basis and practical guidance for China's energy transition and development under the background of carbon emission peaking and achieving carbon neutrality. Guided by the strategic goals of national energy security, carbon emission peaking, and achieving carbon neutrality, this study aims to analyze the global development process and stage characteristics of the CCUS industry, investigate the supporting policies in the CCUS field and their evolution patterns, summarize the current status and trends of the CCUS industry at home and abroad, and provide reference for the implementation of national energy green and low-carbon transformation and the construction of a new energy system. In terms of industry, European and American countries emphasize national-level technological guidance and macro-control. The United States has introduced the progressive 45Q tax credit policy, and the European Union has included CCUS in its carbon trading system. The US National Carbon Capture Center provides a testing environment and facilities for CCUS technology research and development, and has established a carbon dioxide industry cluster and transportation hub. In terms of policies, tax credits and carbon trading policies in Europe and America have attracted various types of capital investment, establishing a relatively complete legal framework system. These regions have been leading in CCUS technology research and deployment, holding dominant positions and decision-making power in mainstream international CCUS organizations such as the CSLF, IEA, GCCSI, and OGCI. This study benchmarks the forward-looking and strategic development status of the CCUS industry at home and abroad, elucidates the challenges facing CCUS industry development, and proposes future trends and policy support needs for the CCUS industry. The research reveals that Europe and America emphasize national-level technological guidance and macro-control, focusing on the construction of regional industrial networks and having established a relatively complete legal and regulatory framework system. Compared to other countries, China needs to establish national-level guidance on CCUS development, regional carbon dioxide capture and transportation networks, and enact specific laws, regulations, and technical standards for CCUS.
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Wesley, Michael J., Terry Lohrenz, Mikhail N. Koffarnus, Samuel M. McClure, Richard De La Garza, Ramiro Salas, Daisy G. Y. Thompson-Lake, Thomas F. Newton, Warren K. Bickel, and P. Read Montague. "Choosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Users." Journal of Addiction 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/189853.
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Addiction is considered a disorder that drives individuals to choose drugs at the expense of healthier alternatives. However, chronic cocaine users (CCUs) who meet addiction criteria retain the ability to choose money in the presence of the opportunity to choose cocaine. The neural mechanisms that differentiate CCUs from non-cocaine using controls (Controls) while executing these preferred choices remain unknown. Thus, therapeutic strategies aimed at shifting preferences towards healthier alternatives remain somewhat uninformed. This study used BOLD neuroimaging to examine brain activity as fifty CCUs and Controls performed single- and cross-commodity intertemporal choice tasks for money and/or cocaine. Behavioral analyses revealed preferences for each commodity type. Imaging analyses revealed the brain activity that differentiated CCUs from Controls while choosing money over cocaine. We observed that CCUs devalued future commodities more than Controls. Choices for money as opposed to cocaine correlated with greater activity in dorsal striatum of CCUs, compared to Controls. In addition, choices for future money as opposed to immediate cocaine engaged the left dorsolateral prefrontal cortex (DLPFC) of CCUs more than Controls. These data suggest that the ability of CCUs to execute choices away from cocaine relies on activity in the dorsal striatum and left DLPFC.
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Wang, Pengtao, Xi Wu, Gangke Ge, Xiaoyan Wang, Haifeng Wang, Yang Zhang, Wei Wang, et al. "Identification of potential CCUS clusters and its pipeline network optimization in China." E3S Web of Conferences 358 (2022): 02015. http://dx.doi.org/10.1051/e3sconf/202235802015.
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Climate change is a huge challenge facing the world. Carbon Capture, Utilization and Storage (CCUS) is an important technology that is expected to ensure the continued safe and large-scale use of fossil energy under the pressure of climate change in China. However, the current CCUS project has a large initial investment, and it is difficult to realize the commercialization of CCUS technology. The development of CCUS cluster centers can effectively reduce the overall investment of CCUS projects, which is the development trend of CCUS projects. This study identified 20 coal-fired power plant cluster centers and 6 oil and gas field gathering and transportation centers by utilizing Chinese coal-fired power plant data and oil and gas field data. Finally, the CO2 pipe network between the cluster centers is planned. This study provides data and research methods for identifying potential CCUS clusters and storage and transportation centers in China. It can provide a theoretical reference for further research on the matching site selection of CO2 transport pipelines and CO2 sources and sinks in China.
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Nielsen, Jacob A. E., Kostas Stavrianakis, and Zoe Morrison. "Community acceptance and social impacts of carbon capture, utilization and storage projects: A systematic meta-narrative literature review." PLOS ONE 17, no. 8 (August 2, 2022): e0272409. http://dx.doi.org/10.1371/journal.pone.0272409.
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This manuscript presents a systematic meta-narrative review of peer-reviewed publications considering community acceptance and social impacts of site-specific Carbon Capture Utilization and Storage (CCUS) projects to inform the design and implementation of CCUS projects who seek to engage with communities during this process, as well as similar climate mitigation and adaptation initiatives. A meta-narrative approach to systematic review was utilized to understand literature from a range of site specific CCUS studies. 53 peer-reviewed papers were assessed reporting empirical evidence from studies on community impacts and social acceptance of CCUS projects published between 2009 and 2021. Three separate areas of contestation were identified. The first contestation was on acceptance, including how acceptance was conceptualized, how the different CCUS projects engaged with communities, and the role of acceptance in social learning. The second contestation related to communities: how communities were represented, where the communities were located in relation to the CCUS projects, and how the communities were defined. The third contestation was around CCUS impacts and the factors influencing individuals’ perceptions of impacts, the role of uncertainty, and how impacts were challenged by local communities, politicians and scientists involved in the projects. The next step was to explore how these contestations were conceptualised, the aspects of commonality and difference, as well as the notable omissions. This facilitated a synthesis of the key dimensions of each contestation to inform our discussion regarding community awareness and acceptance of CCUS projects. This review concludes that each CCUS project is complex thus it is not advisable to provide best practice guidelines that will ensure particular outcomes. This systematic review shared recommendations in the literature as to how best to facilitate community engagement in relation to CCUS projects and similar place-based industrial innovation projects. These recommendations focus on the importance of providing transparency, acknowledging uncertainty and encouraging collaboration.
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Schellong, Sebastian M., T. Schwarz, T. Pudollek, B. Schmidt, and H. E. Schroeder. "Die vollständige Kompressionssonographie zur Diagnose der proximalen und distalen Venenthrombose – eine retrospektive Untersuchung." Vasa 30, no. 4 (November 1, 2001): 253–57. http://dx.doi.org/10.1024/0301-1526.30.4.253.
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Background: Compression ultrasound is considered the preferred test for the diagnosis of deep vein thrombosis of the leg (DVT). Since sensitivity for distal thrombosis is low additional tests are required. We developed a protocol of complete compression ultrasound of all venous segments of the leg (CCUS). A retrospective outcome study was performed to get an estimate of the rate of indeterminate results necessitating repeated testing as well as for the clinical safety of CCUS in a cohort of consecutive, unselected patients. Patients and methods: Case records of all patients referred for clinical suspicion of deep vein thrombosis within a three months period were reviewed. Patients with negative CCUS were followed directly or via the general practitioner in order to know whether an episode of venous thromboembolism had been documented since the initial CCUS. Results: 132 inpatients and 154 outpatients were identified. Clinical probability was high in 50 patients, medium in 142, and low in 94. The first CCUS was negative in 209 cases. Five patients (1,8%) had repeated CCUS within the next 7 days because of incomplete visualisation of the distal veins and turned out to be negative as well. Of all 214 patients with negative CCUS a clinical follow-up information was obtained after 168 ± 25 days. Five patients had died, none due to pulmonary embolism. In two patients deep vein thrombosis had been documented (0,9% [95% CI: 0,1–3,3%]) 148 and 172 days after CCUS, respectively. Conclusion: CCUS for diagnosis of DVT needs to be repeated in very few cases only. Clinical safety seems to fall into the same range as with combined algorithms and should be tested in a prospective design. Patients with medium and high probability showed a very low incidence of DVT within three months following CCUS; therefore, they may be included in a prospective outcome study.
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Cao, Jinhong, Ming Gao, Zhaoxia Liu, Hongwei Yu, Wanlu Liu, and Hengfei Yin. "Research and Application of Carbon Capture, Utilization, and Storage–Enhanced Oil Recovery Reservoir Screening Criteria and Method for Continental Reservoirs in China." Energies 17, no. 5 (February 28, 2024): 1143. http://dx.doi.org/10.3390/en17051143.
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CCUS-EOR is a crucial technology for reducing carbon emissions and enhancing reservoir recovery. It enables the achievement of dual objectives: improving economic efficiency and protecting the environment. To explore a set of CCUS-EOR reservoir screening criteria suitable for continental reservoirs in China, this study investigated and compared the CCUS-EOR reservoir screening criteria outside and in China, sorted out the main reservoir parameters that affect CO2 flooding, and optimized the indices and scope of CCUS-EOR reservoir screening criteria in China. The weights of parameters with respect to their influences on CCUS-EOR were determined through principal component analysis. The results show that there are 14 key parameters affecting CO2 flooding, which can be categorized into four levels. For the first level, the crude oil-CO2 miscibility index holds the greatest weight of 0.479. It encompasses seven parameters: initial formation pressure, current formation pressure, temperature, depth, C2–C15 molar content, residual oil saturation, and minimum miscibility pressure. The second level consists of the crude oil mobility index, which has a weight of 0.249. This index includes four parameters: porosity, permeability, density, and viscosity. The third level pertains to the index of reservoir tectonic characteristics, with a weight of 0.141. It comprises two parameters: permeability variation coefficient and average effective thickness. Lastly, the fourth level focuses on the index of reservoir property change, with a weight of 0.131, which solely considers the pressure maintenance level. Based on the CCUS-EOR reservoir screening criteria and index weights established in this study, comprehensive scores for CCUS-EOR were calculated for six blocks in China. Among these, five blocks are deemed suitable for CCUS-EOR. Based on the comprehensive scoring results, a planning for field application of CCUS-EOR is proposed. The study provides a rational method to evaluate the CCUS-EOR reservoir screening and field application in continental reservoirs in China.
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LIU, GUIZHEN, BOFENG CAI, QI LI, GREGORY LEAMON, LIBIN CAO, and YING ZHOU. "PERCEPTIONS AND ACCEPTANCE OF CCUS ENVIRONMENTAL RISK ASSESSMENT, BY EXPERTS AND GOVERNMENT OFFICERS, IN CHINA." International Journal of Big Data Mining for Global Warming 01, no. 02 (December 2019): 1950010. http://dx.doi.org/10.1142/s2630534819500104.
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In May 2017, Department of Science, Technology and Standards, MEP, China held the first training conference of “2017 CCUS environmental risk assessment technology”. After the conference, specially designed questionnaires were sent to the participants so as to collect the professional opinions to improve the guideline in the next revision. Basic information of participants, knowledge of capture, utilization and geological storage (CCUS), and attitude to the CCUS environmental risk are contained in the questionnaires. The 82 questionnaires were issued to the participants, and 77 valid questionnaires were collected with the response rate of 93.9%. According to the data mining, (a) nearly one third of the participants had not heard of the CCUS before the training; (b) the attitude to CCUS environmental impact and risk is influenced by the knowledge of CCUS; (c) the severities of the three aspects of capture component are medium; (d) for onshore CCUS projects, underground water, atmosphere, soil, and human health were considered the highest sensitivity receptors; (e) the enterprises were very concerned of the CCUS environmental management policies, three most important policies were conducting environmental monitoring across the whole chain, clarifying the environmental management responsibilities, and establishing emergency plans for environmental accidents. The result of this survey would provide the guidance for the improvement of the technical guideline which planned to be released during the official version in 2020.
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Ganan-Gomez, Irene, Bijender Kumar, Juan Jose Rodriguez Sevilla, Feiyang Ma, Yi June Kim, Kelly S. Chien, Kate Nelson, et al. "Mutant Natural Killer Cell Dysfunction Enables the Immune Escape of Premalignant MDS Cell Clones." Blood 142, Supplement 1 (November 28, 2023): 514. http://dx.doi.org/10.1182/blood-2023-184349.
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Myelodysplastic syndromes (MDS) cannot be cured by standard pharmacological therapies owing to their inability to eradicate aberrant hematopoietic stem cells (HSCs). Given that developing early intervention strategies for MDS patients requires an improved understanding of the mechanisms underlying aberrant HSC expansion, we sought to elucidate how MDS HSCs evade immune surveillance and expand in patients with clonal cytopenias of undetermined significance (CCUS), the pre-malignant stage of MDS. To characterize transcriptomic changes induced by CCUS in the aged immune microenvironment, we used single-cell RNA sequencing (scRNA-seq) of bone marrow (BM) mononuclear cells (MNCs) isolated from 2 young healthy donors (yHDs), 2 elderly healthy donors (eHDs), and 3 CCUS patients harboring mutations in MDS driver genes such as DNMT3A or TET2. CCUS immune cells were enriched in CD8 + T effector and NK cells, which were in activated states, characterized by the significant (P adj<0.05) upregulation of genes involved in protein translation, mitochondrial metabolism, and response to interferon signaling. A computational interactome analysis of ligand-receptor pair expression predicted gained intercellular communications among myeloid cells and CD8 + T and NK cells in CCUS patients compared with yHDs and eHDs, consistent with a tumor recognition process. However, CCUS CD8 + T and NK cells had downregulated NF-kB-mediated inflammatory signaling genes, which suggested a loss of proinflammatory capacity. Because an efficient antitumor CD8 + T-cell response requires functional NK cells, we further dissected their functional state by performing scRNA-seq of CD3 + and/or CD56 + BM cells isolated from 2 yHDs, 2 eHDs, and 3 CCUS patients. A trajectory reconstruction analysis showed that CCUS NK cells were in more advanced differentiation states than HD NK cells were, which was confirmed by the significant downregulation of the transcription factor FOXO1 (P adj=1.17 x 10 -81). Differential gene expression analyses revealed that CCUS NK cells had significantly (P adj<0.05) upregulated MYC and mTOR target genes and genes involved in oxidative metabolism, protein synthesis, and immune signaling (consistent with an NK cell proliferative burst) compared with eHD NK cells, which suggests that CCUS NK cells are hyperactivated. However, cytokine secretion assays with K562 cells revealed that NK cells from 5 CCUS patients secreted significantly (P=0.002) less interferon gamma than those from 6 eHDs did. CCUS NK cells and eHD NK cells produced similar levels of granzyme and perforin, and CCUS NK cells could degranulate (based on CD107a expression); however, CCUS NK cells had significantly lower CD16 expression (P=0.008), which suggests an impaired capacity to form stable immune synapses and degranulate in a polarized manner. Indeed, compared with those from 3 yHDs and 4 eHDs, NK cells from 3 CCUS patients had a significantly (P<0.0001) impaired cytolytic capacity against leukemic cells that could not be rescued by prolonged culture with feeder cells. Moreover, NK cells from 4 CCUS patients failed to kill both heterotypic and isotypic CCUS CD34 + cells ex vivo (Fig. 1). To investigate the molecular mechanisms of NK cell dysfunction, we performed joint targeted single-cell DNA sequencing and immunophenotypic analyses of MNCs from 5 CCUS patients with DNMT3A or TET2 mutations, which revealed that NK cells were enriched in aberrant clones and had mutational burdens similar to those of myelomonocytes (Fig. 2). Deletion of DNMT3A or TET2 by CRISPR/Cas9 in cord blood-derived NK cells and subsequent killing assays showed a significant (P<0.0001) progressive loss of cytolytic capacity with tumor re-challenging in knock-out NK cells, which demonstrated that loss of function mutations in those genes are a direct cause of NK cell dysfunction in the context of sustained immune activation. This study demonstrates that MDS driver mutations in CCUS NK cells induce immune dysfunction, thus enabling the expansion of malignant cells and thereby contributing to MDS onset. Our results suggest that immunotherapy with adoptive NK cell transfer could restore the anti-tumor immune response in patients with CCUS and may be an effective approach to arrest disease progression and prevent MDS onset.
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Muslemani, Hasan, Xi Liang, Katharina Kaesehage, and Jeffrey Wilson. "Business Models for Carbon Capture, Utilization and Storage Technologies in the Steel Sector: A Qualitative Multi-Method Study." Processes 8, no. 5 (May 13, 2020): 576. http://dx.doi.org/10.3390/pr8050576.
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Carbon capture, utilization, and storage (CCUS) is a combination of technologies capable of achieving large-scale reductions in carbon dioxide emissions across a variety of industries. Its application to date has however been mostly limited to the power sector, despite emissions from other industrial sectors accounting for around 30% of global anthropogenic CO2 emissions. This paper explores the challenges of and requirements for implementing CCUS in non-power industrial sectors in general, and in the steel sector in particular, to identify drivers for the technology’s commercialization. To do so we first conducted a comprehensive literature review of business models of existing large-scale CCUS projects. We then collected primary qualitative data through a survey questionnaire and semi-structured interviews with global CCUS experts from industry, academia, government, and consultancies. Our results reveal that the revenue model is the most critical element to building successful CCUS business models, around which the following elements are structured: funding sources, capital & ownership structure, and risk management/allocation. One promising mechanism to subsidize the additional costs associated with the introduction of CCUS to industry is the creation of a ‘low-carbon product market’, while the creation of clear risk-allocation systems along the full CCUS chain is particularly highlighted. The application of CCUS as an enabling emission reduction technology is further shown to be a factor of consumer and shareholder pressures, pressing environmental standards, ethical resourcing, resource efficiency, and first-mover advantages in an emerging market. This paper addresses the knowledge gap which exists in identifying viable CCUS business models in the industrial sector which, with the exception of a few industry reports, remains poorly explored in the academic literature.
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Ganan-Gomez, Irene, Kelly S. Chien, Feiyang Ma, Hui Yang, Lin Tan, Philip Lorenzi, Guillermo Garcia-Manero, and Simona Colla. "The Transcriptional and Epigenetic Reprogramming of Aged Hematopoietic Stem Cells Drives Myeloid Rewiring in Clonal Hematopoiesis-Associated Cytopenias." Blood 138, Supplement 1 (November 5, 2021): 3273. http://dx.doi.org/10.1182/blood-2021-150663.
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Abstract Patients (pts) with myelodysplastic syndromes (MDS) have few therapy options. Interventions to improve outcomes should consider strategies that arrest MDS in its early phases, when symptoms are minimal and prolonged survival is expected. To develop prevention strategies that arrest MDS before the disease outcomes become irreversibly dismal, we dissected the molecular and biological mechanisms that maintain MDS in one of its premalignant phases, clonal cytopenia of undetermined significance (CCUS). Recognizing that CCUS is an aging-related disease, we first sought to determine, at the single-cell level, how CCUS affects the transcriptional and epigenetic profile of the aging hematopoietic stem and progenitor cell (HSPC) compartment and overcomes aging-induced degenerative phenotypes. We performed single-cell RNA sequencing (scRNA-seq) analysis of Lin -CD34 + HSPCs isolated from the bone marrow (BM) of 3 young healthy donors (yHDs), 4 elderly HDs (eHDs), and 3 elderly pts with CCUS carrying mutations in common MDS driver genes. We found that the frequencies of hematopoietic stem cells (HSCs) and megakaryocytic (Mk)/erythroid (Er) progenitors were increased at the expense of myeloid (My) progenitors in eHDs as compared with yHDs (Fig. a). In contrast, CCUS pts had a predominant My-biased HSPC distribution (Fig. a). However, immunophenotypic quantification in large cohorts of eHDs and CCUS pts revealed that CCUS pts' BM had significantly fewer CD34 +CD38 - HSC populations and CD34 +CD38 + My progenitors, suggesting that My bias in CCUS results from the aberrant My differentiation of HSCs rather than My cell expansion. Further differential expression analysis among the scRNA-seq clusters showed that, compared with yHD HSCs, eHD HSCs were characterized by a significant upregulation of genes involved in the TNFα-induced activation of NF-κB (e.g., MCL1; Fig. b), which is consistent with previous findings that aged HSCs undergo transcriptional reprogramming to maintain their survival in response to changes in the systemic environment (He et al. Blood 2020). In contrast, CCUS HSCs, compared with eHD HSCs, overexpressed regulators of translation, respiratory electron transport, and mitochondrial translation initiation (Fig. c), which underscores these cells' state of proliferation and metabolic activation and their ability to overcome aging-induced phenotypic alterations. To evaluate whether the aberrant lineage differentiation in eHD and CCUS HSPCs arose from the altered fate determination of HSCs, we performed single-cell assays for transposase-accessible chromatin sequencing to profile chromatin accessibility in sorted HSCs or Lin -CD34 + HSPCs from yHDs, eHDs, and CCUS pts. Consistent with our transcriptomic data, compared with yHD HSCs, eHD HSCs were mostly poised for Mk differentiation, whereas CCUS HSPCs were poised for lymphoid/My differentiation. Indeed, eHD HSCs had an increased activity of transcriptional factors belonging to the NF-κB family and open peaks at the distal elements of genes involved in hemostasis (Fig. d). In contrast, CCUS HSCs were poised to downregulate the expression of genes involved in NF-κB signaling and Mk/Er differentiation (Fig. e). These results suggested that CCUS HSCs are highly metabolically active to maintain My differentiation. Indeed, metabolomic analyses confirmed that intermediates of oxidative phosphorylation were significantly upregulated in CCUS CD34 + cells as compared with eHD CD34 + cells (Fig. f). Further, scRNA-seq analysis of mononuclear cells isolated from the BM of 3 CCUS and 3 eHD samples revealed the widespread upregulation of genes involved in protein processing and mitochondrial metabolism. This analysis also revealed impaired terminal My differentiation despite the HSPC My bias, with decreased frequencies of monocytic cells, and an intriguing expansion of cytotoxic cell subsets in the BM of CCUS pts. In conclusion, our results demonstrate that CCUS HSCs carrying MDS driver mutations evade aging-induced phenotypic degeneration, become metabolically active, and have aberrant My skewing. Our study clarifies the molecular mechanisms underlying MDS initiation and offers an opportunity for early therapeutic intervention. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Stavrianakis, Kostas, Jacob Nielsen, and Zoe Morrison. "Public perception and acceptance of CCUS: preliminary findings of a qualitative case study in Greece." Open Research Europe 3 (November 21, 2023): 205. http://dx.doi.org/10.12688/openreseurope.16663.1.
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The development and implementation of carbon capture, utilisation and storage (CCUS) technologies plays an increasingly important part in European Union (EU) and global decarbonisation policies and strategies that seek to address climate change to achieve the Paris Agreement goals. Several studies have shown the important role social acceptance plays in determining the outcomes of CCUS projects and how social acceptance is shaped by the national and local contexts. Yet most studies on CCUS and social acceptance have focused on countries in northern Europe and North America despite the increasing numbers of CCUS projects in other regions of the world. This study seeks to help address this gap by conducting a case study on how local dynamics shaped people's acceptance and awareness of CCUS in a Greek community. Based on semi-structured interviews with community members near a CCUS pilot plant, this single case study explores the factors and dynamics that shaped the interviewees' perceptions of CCUS technologies. Our findings indicate that, despite the low level of awareness of CCUS technologies, participants could draw on their situated knowledge to identify potential drawbacks with their application. We identified scepticism regarding the adoption of new technologies and the organisations involved based on past experiences, and a notable lack provision of technology and location-specific information as well public engagement by the project consortium. Our recommendations for future projects and community engagement include the early involvement of the public in project development, location-based transparent information, appropriate channels to facilitate knowledge exchange, and educational initiatives to build communities' capability to influence projects.
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Stavrianakis, Kostas, Jacob Nielsen, and Zoe Morrison. "Public perception and acceptance of CCUS: preliminary findings of a qualitative case study in Greece." Open Research Europe 3 (February 13, 2024): 205. http://dx.doi.org/10.12688/openreseurope.16663.2.
Full textAbstract:
The development and implementation of carbon capture, utilisation and storage (CCUS) technologies plays an increasingly important part in European Union (EU) and global decarbonisation policies and strategies that seek to address climate change to achieve the Paris Agreement goals. Several studies have shown the important role social acceptance plays in determining the outcomes of CCUS projects and how social acceptance is shaped by the national and local contexts. Yet most studies on CCUS and social acceptance have focused on countries in northern Europe and North America despite the increasing numbers of CCUS projects in other regions of the world. This study seeks to help address this gap by conducting a case study on how local dynamics shaped people's acceptance and awareness of CCUS in a Greek community. Based on semi-structured interviews with six community members near a CCUS pilot plant, this single case study explores the factors and dynamics that shaped the interviewees' perceptions of CCUS technologies. Our findings indicate that, despite the low level of awareness of CCUS technologies, participants could draw on their situated knowledge to identify potential drawbacks with their application. We identified scepticism regarding the adoption of new technologies and the organisations involved based on past experiences, and a notable lack provision of technology and location-specific information as well public engagement by the project consortium. Our recommendations for future projects and community engagement include the early involvement of the public in project development, location-based transparent information, appropriate channels to facilitate knowledge exchange, and educational initiatives to build communities' capability to influence projects.
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Haferlach, Claudia, Sandra Huber, Constance Regina Baer, Stephan Hutter, Manja Meggendorfer, Wolfgang Kern, Gregor Hoermann, and Torsten Haferlach. "A Proposal for a Classification of Ccus, MDS and AML Primarily Based on Genetic Abnormalities Considering the Biological Continuum of These Entities." Blood 142, Supplement 1 (November 28, 2023): 6492. http://dx.doi.org/10.1182/blood-2023-179188.
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Background: According to the 5 th edition of the WHO classification (WHO 2022) and the International Consensus Classification (ICC) the main parameters used for the definition of CCUS, MDS and AML are cytopenias, dysplasia, blast count and distinct genetic abnormalities. These entities represent a disease continuum as CCUS can progress to MDS and MDS to AML. Thus, we asked the question whether this continuum can be reflected in a proposed comprehensive classification system. Methods: We evaluated 222 CCUS, 718 de novo MDS and 751 de novo AML. The diagnosis was established following WHO 2022. Bone marrow samples were analyzed by cytomorphology, chromosome banding analysis, targeted NGS panel sequencing (median coverage 1500x) and WGS (median coverage 100x). Overall survival (OS) was available for 1552/1691 patients. Median follow-up with respect to OS was CCUS: 1.7 years, MDS: 9.3 years, AML: 6.7 years. Results: In the WHO 2022 classification a subset of AML entities (AML with defining genetic abnormalities (DGA)) is defined by fusions ( PML:: RARA, RUNX1:: RUNX1T1, CBFB:: MYH11, DEK:: NUP214, RBM15:: MRTFA other defined genetic alterations/ ODGA), rearrangements ( KMT2A, NUP98, MECOM) and distinct mutations ( NPM1, CEBPA). These well-established distinct entities were kept in the classification proposal. 511 AML cases (67%) were classified as AML DGA (Figure 1). The remaining 240 AML cases classified as AML myelodysplasia-related and AML defined by differentiation according to WHO 2022 were combined with MDS and CCUS cases and categorized hierarchically into 5 distinct groups based on the presence of the following genetic abnormalities (GA group): 1. 5q deletion, 2. SF3B1 mutation, 3. other spliceosome mutations (SP: SRSF2, U2AF1, ZRSR2), 4. IDH1/2 or DNMT3A or TET2 mutations (I/D/T), 5. None of these (NO) (Figure 1). Next, within these GA groups the presence of progression markers (PM) was evaluated: PM subset A: presence of a) biallelic TP53 alterations ( TP53bi), or b) mutations in RUNX1 or ASXL1 and mutations in RAS pathway genes or KMT2A-PTD (R/A+RAS/PTD); PM subset B: presence of a) complex karyotype without TP53bi (complex), or b) RUNX1,or ASXL1 mutations (R/A), or RAS pathway mutations or KMT2A-PTD (RAS/PTD); PM subset C: absence of these PM. The assignment into GA groups and PM subsets differed substantially between CCUS, MDS and AML. With respect to GA group CCUS, MDS and AML cases were assigned into GA groups del(5q): CCUS (0%), MDS (76%), AML (24%); SF3B1: CCUS (4%), MDS (91%), AML (5%); SP: CCUS (16%), MDS (55%), AML (29%); I/D/T: CCUS (45%), MDS (30%), AML (25%); NO: CCUS (27%), MDS (62%), AML (11%). With respect to PM subsets CCUS, MDS and AML cases were assigned into A: CCUS (1%), MDS (43%), AML (56%); B: CCUS (10%), MDS (54%), AML (36%); C: CCUS (27%), MDS (69%), AML (4%) (Figure 1). Next, OS was evaluated. Median OS for PM subsets A (n=168), B (n=301) and C (n=572) was 0.7, 2.0 and 6.8 years ( p<0.001), respectively and thus were named acute myeloid neoplasm (MN), high risk MN and low risk MN. Median OS in years in each GA group in acute MN was del(5q): 0.3, SF3B1: 0.7, SP: 1.1, I/D/T: 0.9 and NO: 0.3. The respective data for high risk and low risk MN were: 1.9, 3.3, 2.0, 1.5, 1.3 and 6.4, 7.4, 6.9, 5.8, and 6.8 years (Figure 1). Conclusions: The proposed classification aims at reflecting the biological continuum of CCUS, MDS and AML and allows reclassification during the course of the disease without changing the disease entity following the concept of MPN with chronic phase and blast phase. Further, the classification reflects prognosis and also directly indicates potential therapeutic targets. It is flexible as new genetic markers can easily be added without changing the overall concept.
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V., Arunkumar, Prabagaravarthanan R., and Bhaskar M. "Prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) infections among patients admitted in critical care units in a tertiary care hospital." International Journal of Research in Medical Sciences 5, no. 6 (May 27, 2017): 2362. http://dx.doi.org/10.18203/2320-6012.ijrms20172085.
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Background: The emergence of Methicillin-resistant Staphylococcus aureus (MRSA) infections in hospital leads to significant morbidity and mortality. Hence the present study was undertaken to estimate the prevalence of MRSA in critical care units (CCUs) at our centre. The objective of this study was to find the prevalence of MRSA infections in CCUs, to determine their antibiotic profile. And to screen for MRSA in the environment of CCUs in order to find whether they act as a source of infection.Methods: The present cross-sectional study included 100 patients admitted to various CCUs in our hospital. The clinical specimens (urine, Sputum, pus, blood and CSF) were collected from the admitted patients along with environmental samples from these CCUs. Two samples were collected from each patient and subjected to culture and antibiotic susceptibility testing.Results: 168 samples from 100 patients were processed. Out of which five pus samples from five different patients admitted in surgical intensive care unit (SICU) were positive for MRSA infection showing 5% prevalence in CCUs. All MRSA strains were sensitive to vancomycin and teicoplanin. Out of 30 environmental swabs, 1 swab taken from paediatric intensive care unit (PICU) showed positivity for MRSA (3%).Conclusions: CCUs in our hospital have shown 5% prevalence of MRSA among the admitted patients. There was no correlation between environmental MRSA presence and infection in the samples from patient.
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Li, Xiao-Yu, Xu Gao, and Jing-Jing Xie. "Comparison and Clarification of China and US CCUS Technology Development." Atmosphere 13, no. 12 (December 16, 2022): 2114. http://dx.doi.org/10.3390/atmos13122114.
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The content of the China-US CCUS technology development roadmap is summarized based on the roadmap update in 2019. Qualitative analysis and evaluation were conducted from the perspectives of running CCUS demonstrations or industrial projects, CO2 pipeline infrastructure, established regulatory frameworks, policy support, research and development capabilities, and geological storage resources. A simple analysis of the development status of carbon capture, storage, and utilization technology through relevant patent data is provided. Future planning by China and the United States in terms of planning volume, investment funds, related industries, transportation methods, geological storage, geological utilization, other utilization methods, and incentive policies is compared. Overall, US CCUS technology development is in the leading position in the world; it has entered the stage of small-scale commercial promotion, while the overall development level of China’s CCUS technology is still behind the international advanced level in a small-scale experimental demonstration period, and is still in the catch-up stage. However, as the Chinese government has put forward the strategy of “carbon peaking and carbon neutralization”, CCUS has ushered in a golden opportunity for development in China, and some large-scale industrial demonstration projects have been carried out. This study analyzes China’s advantages and challenges in developing CCUS and gives some suggestions on the direction that China’s CCUS development should take in the future.
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Chavez, Monique, Sridhar N. Srivatsan, Christopher A. Miller, Andrew J. Menssen, Ajay Khanna, Jin Shao, Catrina Fronick, et al. "Reduced Subclone Diversity in Clonal Cytopenia of Undetermined Significance Compared to Myelodysplastic Syndrome." Blood 142, Supplement 1 (November 28, 2023): 2696. http://dx.doi.org/10.1182/blood-2023-189591.
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Introduction: Clonal cytopenias of undetermined significance (CCUS) and myelodysplastic syndromes (MDS) represent a disease continuum that are distinguished by the presence of dysplasia in >10% of blood cells. However, morphologic dysplasia is subject to high inter-observer variability, suggesting that dysplasia may not be ideal to differentiate CCUS from MDS. Defining the clonal architecture of samples from cytopenic patients may provide a more accurate objective measure of disease status than dysplasia. We hypothesize that the number and size of subclones is reduced in patients with CCUS compared to MDS, suggesting that increased subclonal diversity is a hallmark of higher-risk disease. Methods: We performed whole genome sequencing with higher exome coverage (eWGS) on bone marrow (n=58) or peripheral blood (n=4) and paired normal DNA from baseline banked samples from patients with CCUS (n=13), MDS (n=29; IPSS-R very low/low [3], intermediate [5], high/very high [19], no score [2]), and secondary AML (sAML) (n=20), including 32 previously reported patients, to define clonal architecture. Putative somatic variants, including 76 genes that are recurrently mutated in myeloid neoplasms, were validated in hematopoietic and paired normal samples, and available serial samples (n=23), using orthogonal target enrichment sequencing platforms achieving higher coverage (~600-1000x). Clonality of validated somatic mutations was defined using SciClone. Results: The absolute neutrophil count, hemoglobin, and platelet counts trended lower in MDS vs CCUS patients (median, 1.3 vs 2 K/ul [ns]; 9.3 vs 11.35 g/dL [p<0.01]; 63 vs 109.5 K/uL [ns], respectively). The ages and median number of total validated somatic mutations identified by eWGS at baseline was similar for CCUS (n=428), MDS (n=300), and sAML patients (n=420.5). We first defined the founding clone (i.e., the dominant clone with the highest median variant allele frequency [VAF]) and subclones. While the number of total clones per sample was not different between CCUS, MDS, and sAML (median, n=3 for each), the median VAF of all the mutations present in the founding clone (i.e., measure of the maximal molecular disease burden) was significantly lower in CCUS (21.3%) compared to MDS (39.2%, p<0.05) and sAML samples (45.2%, p<0.001), but MDS and sAML were not different (p=0.2) (Figure 1A). In contrast, there was no significant difference in the median VAF of subclones in CCUS and MDS samples (13.4% vs 16.8%), which were both lower than sAML (25.3%, p<= 0.01). However, the proportion of patients with no subclones (i.e., only the founding clone detected) was higher for CCUS (5/13 [38.5%]) compared to MDS and sAML (4/29 [13.8%] and 0/20 [0%], respectively, p 0.0006), suggesting that CCUS samples have reduced subclonal diversity compared to MDS. Consistent with this, genes commonly mutated in subclones occurred less frequently in CCUS vs MDS samples, including activated signaling (0/13 vs 6/29) and transcription factor genes (3/13 vs 9/29, respectively). Nine CCUS patients had serial samples sequenced (median 2 serial samples, range 1-5) at a median follow-up of 539 days (range, 84-4066 days). In CCUS patients with serial samples, there was minimal change in the founding clone (0.16%, range -3.7-23.9%) or the subclone median VAFs (0.2%, range -22.4-22.2%), with only 2 patients having a founding clone or subclone VAF increase of >5%. UPN 529198 had the acquisition of a new SRSF2(P95H)-mutant subclone 4066 days after initial banking but remained with stable cytopenias and no MDS (Figure 1B). One CCUS patient developed MDS 70 days after banking with a blast count that increased from 2% to 15% but had a negligible change in the founding clone VAF (2.8% increase). However, 3 subclones did increase in size (max VAF increase of 6.1%). In summary, while the total number of mutations is similar between CCUS, MDS and sAML samples, the clonal architecture varies across diseases. CCUS has a lower total molecular disease burden and a lower proportion of patients with a subclone compared to MDS patients in our cohort. The data suggest that defining clonal architecture and incorporating subclonal complexity in the evaluation of cytopenic patients could provide an objective measure to characterize and monitor disease burden rather than relying on the presence or absence of dysplasia, especially when considering the diagnosis of CCUS and lower-risk MDS.
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Schellong, Sebastian M., Jan Beyer, Kai Halbritter, Benjamin Schmidt, Alexander G. G. Turpie, Bengt I. Eriksson, Frank Misselwitz, and Peter Kälebo. "VENUS - A Study To Validate Centrally Adjudicated Venous Ultrasound Against Venography after Major Orthopaedic Surgery." Blood 106, no. 11 (November 16, 2005): 281. http://dx.doi.org/10.1182/blood.v106.11.281.281.
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Abstract Mandatory, bilateral, centrally adjudicated venography is currently required to assess the incidence of deep vein thrombosis (DVT) in confirmatory trials of new antithrombotic agents. Non-invasive and less cumbersome methods would be welcomed by both patients and investigators. Centrally adjudicated complete compression ultrasound (CCUS) of all leg veins could become an alternative to venography. Despite the fact that no formal validation of venography has ever been performed, CCUS will have to be externally validated against this ’gold standard’ to gain general acceptance and regulatory approval. A substudy of two recent phase IIb trials of a novel, oral anticoagulant for the prevention of venous thromboembolism in patients undergoing elective hip or knee arthroplasty was undertaken to validate CCUS against venography. The studies had similar designs and methodology, and were designed to allow the pooling of data. Mandatory bilateral venography was performed 7±2 days after surgery; CCUS was performed later the same day, with the sonographers blinded to the venography result. All sonographers were required to have completed a training course, and to have obtained personal certification for the standardized examination and documentation procedure. Venograms and CCUS videos were adjudicated centrally by two independent readers at separate locations; discrepancies were resolved by consensus reading. From the 1347 patients participating in the two trials, 870 matching pairs of evaluable venograms and CCUS videos were obtained. Observed prevalences of any DVT, including muscle vein thrombosis, were 19.1% with venography, and 13.0% with CCUS. Sensitivity and specificity values [with 95% confidence intervals (95% CI)] for detecting DVT with CCUS are shown in the table. Although false positives did not severely impair specificity, the small number of true positives detected by CCUS resulted in remarkably low sensitivity, in particular for proximal DVT. Based on these external validation figures, centrally adjudicated CCUS is not a viable technique to replace venography for the screening of DVT early after major orthopaedic surgery in confirmatory trials of novel antithrombotic agents. DVT Sensitivity [% (95% CI)] Specificity [% (95% CI)] Any 27.4 (21.2, 33.6) 95.8 (94.8, 96.8) Proximal 13.0 (−0.7, 26.8) 99.2 (98.9, 99.7) Distal 25.9 (19.7, 32.1) 96.2 (95.3, 97.2)
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Dinh, Vi Am, Paresh C. Giri, Inimai Rathinavel, Emilie Nguyen, David Hecht, Ihab Dorotta, H. Bryant Nguyen, and Ara A. Chrissian. "Impact of a 2-Day Critical Care Ultrasound Course during Fellowship Training: A Pilot Study." Critical Care Research and Practice 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/675041.
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Objectives. Despite the increasing utilization of point-of-care critical care ultrasonography (CCUS), standards establishing competency for its use are lacking. The purpose of this study was to evaluate the effectiveness of a 2-day CCUS course implementation on ultrasound-naïve critical care medicine (CCM) fellows.Methods. Prospective evaluation of the impact of a two-day CCUS course on eight CCM fellows’ attitudes, proficiency, and use of CCUS. Ultrasound competency on multiple organ systems was assessed including abdominal, pulmonary, vascular, and cardiac systems. Subjects served as self-controls and were assessed just prior to, within 1 week after, and 3 months after the course.Results. There was a significant improvement in CCM fellows’ written test scores, image acquisition ability, and pathologic image interpretation 1 week after the course and it was retained 3 months after the course. Fellows also had self-reported increased confidence and usage of CCUS applications after the course.Conclusions. Implementation of a 2-day critical care ultrasound course covering general CCUS and basic critical care echocardiography using a combination of didactics, live models, and ultrasound simulators is effective in improving critical care fellows’ proficiency and confidence with ultrasound use in both the short- and long-term settings.
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Pal, Mayur, Viltė Karaliūtė, and Shruti Malik. "Exploring the Potential of Carbon Capture, Utilization, and Storage in Baltic Sea Region Countries: A Review of CCUS Patents from 2000 to 2022." Processes 11, no. 2 (February 16, 2023): 605. http://dx.doi.org/10.3390/pr11020605.
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Carbon capture, utilization, and storage (CCUS) refers to technologies that capture carbon dioxide (CO2) emissions from sources such as power plants, industrial facilities, and transportation, and either store it underground or use it for beneficial purposes. CCUS can play a role in reducing greenhouse gas emissions and mitigating climate change, as CO2 is a major contributor to global warming. In the Baltic Sea region countries (BSR), patent searches from 2000 to 2020 reveal that CCUS technologies are focused on CO2 storage, monitoring, utilization, and transport. However, the adoption and deployment of these technologies has been slow due to a variety of factors, including a lack of government action on climate change, public skepticism, increasing costs, and advances in other options such as renewables and shale gas. Overall, CCUS has the potential to significantly reduce CO2 emissions and contribute to climate change mitigation efforts, but more work is needed to overcome the barriers to its widespread adoption in the BSR and elsewhere. This could include policy measures to incentivize the use of CCUS technologies, public education and outreach efforts to increase understanding and support for CCUS, and research and development to improve the efficiency and cost-effectiveness of these technologies.
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Li, Marissa, Terra Lasho, Alejandro Ferrer, Naseema Gangat, Aref Al-Kali, Abhishek A. Mangaonkar, Michelle Elliot, et al. "Clinical, Molecular, and Prognostic Comparisons between Clonal Cytopenias of Undetermined Significance and Lower-Risk Myelodysplastic Syndromes - a Study of 184 Molecularly Annotated Patients." Blood 136, Supplement 1 (November 5, 2020): 35–36. http://dx.doi.org/10.1182/blood-2020-134963.
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Introduction Clonal cytopenias of undetermined significance (CCUS) is defined by the presence of somatic driver mutations/copy number variations in hematopoietic cells in patients with low blood counts, in the absence of morphological evidence for myeloid neoplasms. Patients with CCUS are often symptomatic and can be transfusion dependent (TD), with high rates of progression to myeloid neoplasms, especially myelodysplastic syndromes (MDS). In addition, similar to MDS, there are reports of CCUS patients responding to hypomethylating agents. Due to the lack of a formal diagnosis/morphological dysplasia, CCUS patients are often denied therapies or clinical trial enrollment. We carried out this study to validate our hypothesis that CCUS shares similar clinical and survival characteristics with lower risk MDS (LR-MDS). Methods CCUS patients were prospectively identified from the clonal hematopoiesis clinic, whereas LR-MDS patients were retrospectively identified from our institutional database. LR-MDS was defined as very low, low and intermediate risk MDS based on the R-IPSS categorization. Baseline demographics, blood counts, bone marrow (BM) morphology, cytogenetics, and NGS results were abstracted. Transfusion dependency was defined as requiring at least one unit of red cell or platelets every 4 weeks. The Mann-Whitney-U and Fischer's exact test were used to compare quantitative and qualitative data in subgroups. Kaplan-Meier overall survival (OS) estimates were used for survival analysis and compared using the log-rank test. Results 186 patients were included in the study; 74 (40%) with CCUS and 112 (60%) with LR-MDS, median age 66 years, with 63% being male (Table 1). In the CCUS group, 93% had one or more mutations (67% >1 mutation) detected by NGS, while 7% had clonal cytogenetic abnormalities. Common mutations in CCUS included TET2 (30%), SRSF2 (20%), DNMT3A (13%) and ASXL1 (11%); with 28% of patients being red cell TD and 15% being platelet TD. On application of the R-IPSS stratification, 40%, 45%, 12% and 3% were in the very low, low, intermediate and high risk categories, respectively. LR-MDS subtypes included MDS-RS (50%), MDS-MLD (21%), MDS-EB (10%), MDS del5q (7%), and MDS-U (12%). SF3B1 mutations were seen in 67% (95% of MDS-RS), while TET2 and DNMT3A mutations were seen in 29% and 21%, respectively. 60% of LR-MDS patients had >1 mutation. 44% were red cell TD, while 10% were platelet TD. In comparison to patients with CCUS, LR-MDS patients were more likely to have higher white blood cell counts (p=0.002), higher neutrophil counts (p=0.009), higher platelet counts (p<0.001), be red cell TD (p=0.031), have BM ring sideroblasts (p<0.001), have higher BM blast% (p=0.004) and carry SF3B1 mutations (p<0.001); whereas CCUS patients were more likely to have higher monocyte counts (p=0.009) and more likely to carry IDH1 (p=0.005), ZRSR2 (p=0.005) and ATM (p=0.012) mutations. Importantly there were no differences with regards to R-IPSS cytogenetic risk groups, R-IPSS prognostic categories, platelet TD, and mutations involving TET2, DNMT3A, SRSF2 and ASXL1 and TP53. Notably signal pathway mutations and mutations involving tumor suppressor genes were infrequent (<5%) in both groups. The LR-MDS patients had a longer median follow up (53 vs 15 months) and at last follow up 72 (64%) and 11 (15%) deaths had been documented in the LR-MDS and CCUS groups respectively. 13 (18%) CCUS patients progressed to MDS (10) and AML (3) over a median of 15 months, while 9 (8%) LR-MDS patients progressed to higher grade MDS (1) and AML (8), respectively (median follow up 53 months). There was no difference in the median survival between CCUS (median OS not reached) versus LR-MDS (median OS 8.3 years) (p=0.372, Figure 1). Conclusion In spite of subtle phenotypic/molecular differences between LR-MDS and CCUS, both entities had similar prognostication, distribution of high risk mutations and survival outcomes. Within a short follow-up, 18% of CCUS patients progressed to MDS/AML, indicating that regardless of the absence of dysplasia these entities are a continuum of myeloid neoplasms. In order to improve access to treatments and clinical trial opportunities, we recommend that close consideration be given to consider CCUS as a MDS subtype. Disclosures Shah: Dren Bio: Consultancy.
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Koh, Moon-Hyun. "CO2 Capture, Utilization, and Storage (CCUS) Policy Trends in the European Union (EU) and Major European Countries." Korean Public Land Law Association 100 (November 30, 2022): 463–83. http://dx.doi.org/10.30933/kpllr.2022.100.463.
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According to the 1st Working Group (WG) report of the 6th Assessment Report (AR 6) of the Intergovernmental Panel on Climate Change (IPCC) published on August 9, 2021, the average global temperature is now higher than before industrialization. It has already risen 1.09〬 C, and the average carbon dioxide concentration in the atmosphere is 410ppm, the highest level in 2 million years. If carbon emissions continue according to the current trend, it is highly likely that the temperature rise limit target according to the Paris Agreement and the threshold of an irreversible climate catastrophe will reach 1.5〬 C within 20 years at the most. With such a prospect, it is not enough to emphasize the importance of technology development to reduce greenhouse gas, which threatens the survival of mankind. Carbon Dioxide Capture, Utilization and Storage (CCUS) technology, which is a representative technology for large-scale reduction of greenhouse gas, which is the main cause of global warming, has recently attracted attention. The national vision of achieving carbon neutrality in 2050 is closely related to the implementation of the Nationally Determined Contribution (NDC) under Articles 3 and 4 of the Paris Agreement. Carbon dioxide capture, utilization and storage (CCUS) technology is a representative technology for large-scale reduction of greenhouse gases closely related to achieving carbon neutrality in 2050. In order to increase the effectiveness of Korean CCUS technology, it is important to consider overseas advanced CCUS policies. Accordingly, in this report, examples of carbon dioxide capture, transport, utilization and storage (CCUS) projects that can be seen as part of the Green New Deal policies of the European Union (EU) and major European countries and carbon dioxide in major European countries such as Germany, Norway and the United Kingdom Recent policy trends on capture, transport, utilization and storage (CCUS) are reviewed. Through this, first, CCUS is an important means to achieve 2050 carbon growth by supplementing the problems of new and renewable energy such as intermittent, inefficiency, and noise pollution. Because it is important, regular and occasional disclosure of information to residents and enhancement of public acceptance through resident meetings and seminars are very important. Third, the United States, Canada and China are CCUS powerhouses as well as major European countries such as Germany, Norway, the United Kingdom and the Netherlands. As above mentioned CCUS powerhouses are spurring CCUS research and development, if Korea neglects research and development on CCUS, it will fall into a technology-dependent country. Through this, implications such as that Korea should achieve the carbon-neutral 2050 target and achieve sustainable development were derived.
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Koh, Moon-Hyun. "CO2 Capture, Utilization, and Storage (CCUS) Policy Trends in the European Union (EU) and Major European Countries." Korean Public Land Law Association 100 (November 30, 2022): 463–83. http://dx.doi.org/10.30933/kpllr.2022.100.463.
Full textAbstract:
According to the 1st Working Group (WG) report of the 6th Assessment Report (AR 6) of the Intergovernmental Panel on Climate Change (IPCC) published on August 9, 2021, the average global temperature is now higher than before industrialization. It has already risen 1.09〬 C, and the average carbon dioxide concentration in the atmosphere is 410ppm, the highest level in 2 million years. If carbon emissions continue according to the current trend, it is highly likely that the temperature rise limit target according to the Paris Agreement and the threshold of an irreversible climate catastrophe will reach 1.5〬 C within 20 years at the most. With such a prospect, it is not enough to emphasize the importance of technology development to reduce greenhouse gas, which threatens the survival of mankind. Carbon Dioxide Capture, Utilization and Storage (CCUS) technology, which is a representative technology for large-scale reduction of greenhouse gas, which is the main cause of global warming, has recently attracted attention. The national vision of achieving carbon neutrality in 2050 is closely related to the implementation of the Nationally Determined Contribution (NDC) under Articles 3 and 4 of the Paris Agreement. Carbon dioxide capture, utilization and storage (CCUS) technology is a representative technology for large-scale reduction of greenhouse gases closely related to achieving carbon neutrality in 2050. In order to increase the effectiveness of Korean CCUS technology, it is important to consider overseas advanced CCUS policies. Accordingly, in this report, examples of carbon dioxide capture, transport, utilization and storage (CCUS) projects that can be seen as part of the Green New Deal policies of the European Union (EU) and major European countries and carbon dioxide in major European countries such as Germany, Norway and the United Kingdom Recent policy trends on capture, transport, utilization and storage (CCUS) are reviewed. Through this, first, CCUS is an important means to achieve 2050 carbon growth by supplementing the problems of new and renewable energy such as intermittent, inefficiency, and noise pollution. Because it is important, regular and occasional disclosure of information to residents and enhancement of public acceptance through resident meetings and seminars are very important. Third, the United States, Canada and China are CCUS powerhouses as well as major European countries such as Germany, Norway, the United Kingdom and the Netherlands. As above mentioned CCUS powerhouses are spurring CCUS research and development, if Korea neglects research and development on CCUS, it will fall into a technology-dependent country. Through this, implications such as that Korea should achieve the carbon-neutral 2050 target and achieve sustainable development were derived.
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Zhan, Yu. "Analysis on application status of CCUS technology in emission reduction of modern coal chemical project in chemical industry." E3S Web of Conferences 520 (2024): 02028. http://dx.doi.org/10.1051/e3sconf/202452002028.
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To gain a deeper understanding of the current application status of carbon capture, utilization, and storage (CCUS) technology in modern coal chemical projects aimed at reducing emissions in the chemical industry, a study on the application of CCUS technology in emission reduction in the chemical industry was proposed. This article provides a detailed summary of the application status of CCUS technology in the global chemical industry, comprehensively sorts out its technical classification and characteristics, and deeply analyzes the carbon emission characteristics of modern coal chemical industry. On this basis, a comprehensive analysis was conducted on the main technical, economic, and policy issues faced by the modern coal chemical industry in promoting the application of CCUS technology. Through the analysis and research of these issues, some suggestions have been made, including strengthening top-level planning, focusing on solving CCUS technology challenges, enhancing policy support, etc., to promote better progress in the modern coal chemical industry in carbon capture technology engineering demonstration and low-carbon development.
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Liu, H. J., P. Were, Q. Li, Y. Gou, and Z. Hou. "Worldwide Status of CCUS Technologies and Their Development and Challenges in China." Geofluids 2017 (2017): 1–25. http://dx.doi.org/10.1155/2017/6126505.
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Carbon capture, utilization, and storage (CCUS) is a gas injection technology that enables the storage of CO2 underground. The aims are twofold, on one hand to reduce the emissions of CO2 into the atmosphere and on the other hand to increase oil/gas/heat recovery. Different types of CCUS technologies and related engineering projects have a long history of research and operation in the USA. However, in China they have a short development period ca. 10 years. Unlike CO2 capture and CO2-EOR technologies that are already operating on a commercial scale in China, research into other CCUS technologies is still in its infancy or at the pilot-scale. This paper first reviews the status and development of the different types of CCUS technologies and related engineering projects worldwide. Then it focuses on their developments in China in the last decade. The main research projects, international cooperation, and pilot-scale engineering projects in China are summarized and compared. Finally, the paper examines the challenges and prospects to be experienced through the industrialization of CCUS engineering projects in China. It can be concluded that the CCUS technologies have still large potential in China. It can only be unlocked by overcoming the technical and social challenges.
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Sitinjak, Charli, Sitinjak Ebennezer, and Józef Ober. "Exploring Public Attitudes and Acceptance of CCUS Technologies in JABODETABEK: A Cross-Sectional Study." Energies 16, no. 10 (May 11, 2023): 4026. http://dx.doi.org/10.3390/en16104026.
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One of the most essential elements of environmental protection is an appropriate policy towards carbon capture, utilisation, and storage (CCUS). On the one hand, these technologies are being dynamically developed. Still, on the other hand, we often encounter social resistance to change and new technologies, which is one of the main barriers to their implementation. This research examined public acceptance and awareness of Indonesia’s CCUS technologies. Five hundred respondents completed an online survey representing Jakarta, Bogor, Depok, Bekasi, and Tangerang. The study found that the respondents had more favourable feelings towards carbon capture and utilisation (CCU) than CO2 capture and storage (CCS), perceiving CCU as more innovative, necessary, cost-effective, secure, environmentally friendly, and beneficial to regional and national economies than CCS. However, in Indonesia, most respondents did not embrace the development of CCUS technology due to a lack of knowledge and fear, which can lead to violence. The results indicate that an individual’s awareness of perceived risks and the ability to safeguard the environment are crucial to their acceptance of CCUS technology. These findings contribute to understanding the public perception of CCUS technologies in Indonesia and can help to develop effective communication strategies to improve public understanding and acceptance of CCUS initiatives.
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Gu, Changwan, Jingjing Xie, Xiaoyu Li, and Xu Gao. "Levelized Cost Analysis for Blast Furnace CO2 Capture, Utilization, and Storage Retrofit in China’s Blast Furnace–Basic Oxygen Furnace Steel Plants." Energies 16, no. 23 (November 28, 2023): 7817. http://dx.doi.org/10.3390/en16237817.
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As the largest carbon emitter in China’s manufacturing sector, the low-carbon transition of the steel industry is urgent. CO2 capture, utilization, and storage (CCUS) technology is one of the effective measures to reduce carbon emissions in steel industry. In this paper, a comprehensive assessment model of source–sink matching-levelized cost in China’s steel industry is constructed to evaluate the potential, economy, and spatial distribution of CCUS retrofits of blast furnaces in the BF-BOF steel industry. The results show that, if no extra incentive policy is included, the levelized cost of carbon dioxide (LCOCD) of 111 steel plants with a 420.07 Mt/a CO2 abatement potential ranges from −134.87 to 142.95 USD/t. The levelized cost of crude steel (LCOS) range of steel plants after the CCUS retrofits of blast furnaces is 341.81 to 541.41 USD/t. The incentives such as carbon market and government subsidies will all contribute to the early deployment of CCUS projects. The CCUS technology could be prioritized for deployment in North China, Northwest China, and East China’s Shandong Province, but more powerful incentives are still needed for current large-scale deployment. The research results can provide references for the early deployment and policy formulation of CCUS in China’s steel industry.
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Kumar, Munish, and Gabriel Lauderdale-Smith. "Petrophysical Considerations for CO2 Capture and Storage." Petrophysics – The SPWLA Journal of Formation Evaluation and Reservoir Description 65, no. 1 (February 1, 2024): 51–69. http://dx.doi.org/10.30632/pjv65n1-2024a3.
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Carbon capture, utilization, and storage (CCUS) is a process that involves capturing carbon dioxide (CO2) emissions and storing them in geological formations. While the challenge of CCUS is one of multiple disciplines, this paper will discuss the key petrophysical considerations worth noting for CCUS projects. As the storage capacity and effectiveness of the storage reservoir depend on the physical and chemical properties of the geological formations that are used for storage, petrophysicists working on CCUS projects must have a good understanding of the subsurface and its limitations. Any CCUS project can be better managed by application and adherence to the CO2 Storage Resources Management System (SRMS), which aims to develop a consistent approach to estimating storable quantities of CO2 in the subsurface and evaluating development projects. In this paper, we will also discuss a risk matrix that we have designed as a tool for project petrophysicists to document uncertainties and rank them to enhance communication with team members. We finally share a petrophysical checklist to highlight considerations as the evaluation of prospective, contingent, and (commercial storage) capacity-scale CCUS projects are matured and use a well in the North West Shelf, Australia, as a case study to show how reservoirs can be analyzed for suitability for CO2 storage.
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Miu, Luciana. "Public perceptions of CCUS in Central and Eastern Europe – implications for community engagement." Baltic Carbon Forum 2 (October 13, 2023): 6–7. http://dx.doi.org/10.21595/bcf.2023.23580.
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Carbon capture, utilization, and storage (CCUS) is emerging as a subject of major interest for EU climate policy due to their potential role in avoiding hard-to-abate CO2 emissions, as well as to lead to “negative emissions” through direct air capture or bioenergy with carbon capture and storage. Despite CCUS technologies being deployed since the 1970s, their widespread implementation is still challenged by a range of factors, including policy inertia, high costs, and relative novelty in the public discourse. In particular, as CCUS emerges slowly into the realm of public and political debate, opinions on these technologies and associated projects are easily changeable and affected by a range of factors, which make concerted public and community engagement extremely important for deploying them where they matter most.The Central and Eastern Europe (CEE) region is characterized by a higher-than-average economic dependence on heavy industry, old assets and infrastructure, and a high occurrence of regions where the transition to climate neutrality will have a significant impact on local economies, employment, and social welfare [1]. CCUS could play an important role in decarbonizing the heavy industry sectors of the region, particularly given the potentially significant storage capabilities of countries such as Romania and Poland, as well as emerging storage potential in the Black Sea and Eastern Mediterranean Sea. However, climate policy in these jurisdictions is sluggish, and there is a general failure to approach CCUS in a systematic way, with targeted application to sectors where it can have the highest impact, such as cement and oil refining. As a result, the public debate around CCUS is practically non-existent, and where public opinions do emerge, they may be significantly influenced by the context of a particular project and generate significant resistance based on the relationship with project developers, the amplification of perceived risks, and the lack of appropriate explanations of costs, benefits and risks. This in turn can lead to a reticence of political stakeholders to commit to deploying CCUS, causing the public debate to further stagnate and creating a vicious circle whereby opportunities to familiarize the public with these technologies (well in advance of their deployment) are missed.In order to deploy CCUS at pace and scale, as part of the catching-up climate policies of CEE countries, public perception of CCUS must be thoroughly researched and developed into appropriate guidelines for community engagement by project developers. There is experience in the region – the feasibility study for Romania’s planned Getica CCS demonstrator (subsequently abandoned) included comprehensive research into the perceptions of local communities, and a toolkit for communications around CCUS by project developers. Similarly, learnings from Poland’s failed Belchatow CCS project can serve to re-assess the state of public opinion on CCS, and how the local and national-level contexts for CCUS perceptions interact. The CEE region has significant potential for deploying CCUS, and public perception must be an integral part of planning as the region moves into the key decade of 2030-2040 for implementing large-scale projects.
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Zhou, Shan. "President's Page: CCUS: Challenges and opportunities." Leading Edge 43, no. 4 (April 2024): 206. http://dx.doi.org/10.1190/tle43040206.1.
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Carbon capture, usage, and storage (CCUS) technologies can move carbon dioxide produced from fossil-fueled power plants and other industrial facilities to geologic storage sites at a distance. Due to the pressing societal need to reduce greenhouse gas emissions, CCUS has gained wide attention as a flexible, cost-effective, and rapid approach to climate change mitigation and energy security. CCUS is particularly appealing to industries for which decarbonizing has been historically challenging.
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Gallo, Alexandre, Eduardo G. Pereira, Alberto Fossa, Hannah Hylton-Edwards, Thomas Muinzer, Edmilson Moutinho Dos Santo, Clara Dybwad, and Cylon Liaw. "Towards the International Standardization of Carbon Dioxide Capture, Transportation, Utilization and Storage (CCUS) Technologies: Current Challenges and Future Directions." Journal of Sustainable Development Law and Policy (The) 12, no. 2 (December 13, 2021): 157–89. http://dx.doi.org/10.4314/jsdlp.v12i2.2.
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Climate change poses a serious threat to the development of the current and future generations. Therefore, Carbon Dioxide Capture, Transportation, Utilization and Storage (CCUS) has emerged as an essential tool to mitigate such impacts of global warming along with other initiatives and strategic decisions such as energy transition and conservation, sustainable practices amongst others. This article is focused on the CCUS practices and more specifically the peculiarities of CCUS vis-à-vis the standardization rules at the International Organization for Standardization (ISO). The main question this article aims to address is to determine if CCUS should have its own standing technical committee (TC) or if it should be somehow related to the existing Carbon Capture and Storage (CCS) technical committee.
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Singleton, Scott. "President's Page: Leading the way to a carbon-neutral world." Leading Edge 40, no. 10 (October 2021): 712–13. http://dx.doi.org/10.1190/tle40100712.1.
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Carbon capture and storage (CCS) and carbon capture, utilization, and storage (CCUS) are expanding at lightning speed as the world increasingly embraces the need for a carbon-neutral future. As it is described on the U.S. Department of Energy (DOE) website, “CCUS is a process that captures carbon dioxide emissions from sources like coal-fired power plants and either reuses or stores it so it will not enter the atmosphere. Carbon dioxide storage in geologic formations includes oil and gas reservoirs, unmineable coal seams and deep saline reservoirs — structures that have stored crude oil, natural gas, brine and carbon dioxide over millions of years” ( https://www.energy.gov/carbon-capture-utilization-storage ). The International Energy Agency (IEA) states that “CCUS is the only group of technologies that contributes both to reducing emissions in key sectors directly and to removing CO2 to balance emissions that are challenging to avoid – a critical part of “net-zero” goals. After years of slow progress, new investment incentives and strengthened climate goals are building new momentum behind CCUS” ( https://www.iea.org/reports/ccus-in-clean-energy-transitions ).
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Bertone, Michele, Luca Stabile, and Giorgio Buonanno. "An Overview of Waste-to-Energy Incineration Integrated with Carbon Capture Utilization or Storage Retrofit Application." Sustainability 16, no. 10 (May 14, 2024): 4117. http://dx.doi.org/10.3390/su16104117.
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This paper provides an overview of the integration of Carbon Capture, Utilization, or Storage (CCUS) technologies with Waste-to-Energy (WtE) incineration plants in retrofit applications. It explains the operational principles of WtE incineration, including the generation of both biogenic and fossil CO2 emissions and the potential for CCUS technologies to mitigate these emissions. In addition, the paper covers the regulatory framework influencing the adoption of such technologies and highlights the recent Directive 2023/959 for the inclusion of WtE incinerators in the European Union Emissions Trading System (EU ETS) by 2028. This measure could provide a significant impulse for the integration of CCUS in WtE incineration plants. Moreover, it discusses the use of CO2 captured, which could be used in Carbon Capture and Storage (CCS) and Carbon Capture and Utilization (CCU), and offers a comparison of the CCUS projects that have already been implemented worldwide, with a focus on the Netherlands and Italy. It illustrates the Netherlands’ advantageous position due to its developed CO2 market and early CCUS adoption, compared to Italy’s emerging market and initial storage solutions.
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Wang, He. "Analyzing the current state and future development of carbon capture, utilization and storage (CCUS) strategies and technologies in China." Journal of Physics: Conference Series 2608, no. 1 (October 1, 2023): 012061. http://dx.doi.org/10.1088/1742-6596/2608/1/012061.
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Abstract Carbon capture, utilization, and storage (hereafter as CCUS) encompass the procedures of capturing carbon dioxide before it is emitted into the atmosphere, transporting it via pipelines or vehicles and finally utilizing it or storing it in a secure manner. CCUS is vital in transitioning the world into more sustainable and low carbon energy production since it serves as a temporary “band-aid” in reducing the impacts of humanity’s high dependence on fossil fuels. The Chinese government has recently committed itself to reach carbon neutrality by 2060 and CCUS technologies will be a critical cornerstone in reaching this substantial goal. Up to 60% of China’s energy supply in 2019 derived from coal, thus an effective CCUS strategy integrated with the 1,110 operational Chinese coal power plants could be decisive in reaching their carbon neutrality goal. This research paper will analyze the most effective best available technologies (BATs) in terms of cost efficiency and practicality, providing a comprehensive report on the optimal steps for China to take in order to reach its carbon neutral goals through CCUS.
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Hansen, Lein Mann. "Australia well positioned to become a CCUS leader." APPEA Journal 62, no. 2 (May 13, 2022): S25—S28. http://dx.doi.org/10.1071/aj21107.
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Australia’s carbon capture, utilisation and storage (CCUS) sector could be set for fresh boost as oil and gas players are investing heavily in large-scale projects. In 2020, Australia emitted around 499 million tonnes of CO2-equivalent (CO2e). Country-wide, only 2.5 million tonnes of CO2 is captured and stored annually in the Gorgon CCUS project. Starting its CCUS journey on the wrong foot, Australia’s ambitious Gorgon project suffered from cost overruns, delays and much lower capture rates than planned. Nevertheless, 3 years after startup we now see renewed momentum on the back of significant budgetary support from the Federal Government, in addition to inclusion of CCUS projects in the Emissions Reduction Fund and Australian Carbon Credit Units (ACCU), which increased its value ever since. Large players are sizing up opportunities for CCUS in the country and to invest in research and development of next-generation CCUS as well as direct air capture technologies. Considering the vast CO2 storage potential in depleted oil and gas fields and saline aquifers, Rystad Energy have identified three potential storage hotspots in Australia: the northwestern hub, the mid-eastern hub and the southeastern hub. These storage hubs have a cumulative CO2 storage potential of 855 gigatonnes, that is located near to important industrial clusters and is sufficiently large, so it does not pose any barrier for CO2 storage.
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Fu, Yao, Yibo Wang, and Tongyang Zheng. "The Current Status and Future Prospects of Carbon Capture, Carbon Transportation, And Carbon Utilization Technologies in Chinese Coal-Fired Power Plants Within the Context of Dual Carbon Goals." Highlights in Science, Engineering and Technology 96 (May 5, 2024): 116–25. http://dx.doi.org/10.54097/rs28cm11.
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Carbon dioxide capture, utilization, and storage (CCUS) constitute vital measures for achieving net emissions reduction in China. Against the backdrop of the “dual carbon” initiative in China, this paper meticulously examines and analyzes the key technological principles, merits and demerits, and bottlenecks associated with CCUS carbon capture in the country’s thermal power plants at the current stage. It combines the prevailing industrial application status and the future development trajectory of pertinent technologies with considerations of industrial economic benefits and business models. Building upon this analysis, the paper summarizes the application status of CCUS technology in China’s thermal power plant industry and presents future prospects. On the technological front, the three capture methods grapple with the challenge of high costs. Therefore, there is a need to intensify efforts in developing low-cost and efficient carbon capture materials, as well as researching and practically applying low-cost oxygen generation technology. Economically, CCUS technology currently faces high costs, low returns, and certain commercial barriers, placing China in a demonstrative business model stage. To overcome these challenges and realize the economic benefits of CCUS technology, government incentives and technological innovation are imperative. These measures aim to reduce the overall cost of CCUS technology, stimulate the scale development, and foster commercialization, ultimately contributing to the achievement of China’s carbon emission reduction targets.
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RATNER, Svetlana V., and Anastasiya V. SINEL'NIKOVA. "Analysis of trends and development factors of carbon capture and storage technologies in Russia and abroad." Economic Analysis: Theory and Practice 22, no. 9 (September 28, 2023): 1725–45. http://dx.doi.org/10.24891/ea.22.9.1725.
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Subject. The article deals with hydrogen and carbon capture, use and storage technologies (CCUS). Without them it is impossible to achieve the goals of decarbonization of the world economy in 2050. However, currently, the speed of CCUS technologies development is significantly lower than previously expected. Objectives. The study aims to review the dynamics and factors of CCUS technologies development and analyze the most commercially promising areas of their industrial application in Russia. Methods. The study draws on methods of literature review, content analysis of regulatory documentation, descriptive statistics, and case study. The analytical reviews of the International Energy Agency and the CCUS project database of the Global CCS Institute served as the information base of the paper. Results. Currently, the U.S. remains the leader in the practical use of CCUS technologies due to extensive network of pipelines, through which CO2 can be transported, high demand for carbon dioxide generated by numerous oil producing companies for use in enhanced oil recovery technologies, and government financing programs, including those introduced after the global financial crisis of 2008–2009. The most promising areas of CCUS technologies implementation are energy, heavy industry, long-distance transportation, and low-carbon hydrogen production. Conclusions. In the world, the main barriers to CCUS technologies development are the instability of national policies of the leading countries in the field of restrictions on CO2 emission. In Russia, these barriers are sanction restrictions on the country's energy sector, declining growth rates of hydrogen energy due to reduced access to foreign innovative developments, and increased barriers to entry into international markets of innovative energy products of the Russian Federation.
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Carpenter, Chris. "Study Describes Challenges, Opportunities of CO2 EOR in China." Journal of Petroleum Technology 74, no. 07 (July 1, 2022): 87–89. http://dx.doi.org/10.2118/0722-0087-jpt.
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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 209468, “CCUS In China: Challenges and Opportunities,” by Hu Guo, China University of Petroleum; Xiuqin Lyu, Sinopac Northwest Oil Field Company; and En Meng, China University of Petroleum, et al. The paper has not been peer reviewed. One of the most attractive carbon capture, usage, and storage (CCUS) applications in China is that of carbon dioxide (CO2) enhanced oil recovery with captured CO2 (CCS EOR). CO2 EOR with captured CO2 presents an important path for China. The complete paper reviews the progress of CCUS technology in China. The current challenges of CCS EOR include high capture costs, small scale, low incremental oil recovery, and huge capital input. The costs can be significantly reduced when the scale is enlarged to the commercial level and transportation costs are further reduced by pipelines or trains. Importance of CCUS At the time of writing, 49 CCUS pilots or field tests had been conducted or were under construction in China. CCUS demonstration projects were small-scale, and no projects involving more than 1.0 million tons of CO2 per year (mtpa) were conducted. 1.3 million tons of CO2 were estimated to be injected in 2020 for EOR use. The authors reference a study that mentions nine CO2 EOR projects. Among these, the Jilin oilfield project was notable for its size of 2.0 million cumulative tons of CO2 injected. CO2-enhanced coalbed methane was also an attractive option for China, and several field tests were conducted by CNOOC and its partners. Another notable CCUS demonstration project involved the Shaanxi Jinjie power plant. This was the largest coal-fired power postcombustion (PC) CO2-capture project, with a capture capacity of 0.15 mtpa. The project began in November 2019. In January 2021, equipment installation was completed. By June of 2021, 168 trial operations had been passed. The captured CO2 will be used for EOR. This demonstration project will gain knowledge to reduce PC CO2 emissions, a great challenge for China because the majority of electricity is based on coal combustion. Gas processing and power plants rank first for the US in terms of CCUS project numbers. Power plants also rank first in the number of CCUS projects for China, but the number of natural-gas-processing projects was much less.
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Li, Peilin, Lina Che, Luhe Wan, and Liguo Fei. "A MULTIMOORA-Based Risk Evaluation Approach for CCUS Projects by Utilizing D Numbers Theory." Axioms 11, no. 5 (April 26, 2022): 204. http://dx.doi.org/10.3390/axioms11050204.
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As the global climate warms, carbon emissions must be reduced in order to alleviate the human climate crisis. Carbon capture, utilization and storage (CCUS) is an emerging technology that can reduce carbon emissions. However, most of the CCUS projects have ended in failure. The reason can be attributed to insufficient risk assessment. To this end, the purpose of this study is to construct a comprehensive risk assessment model for CCUS projects. The main body of this research is divided into two parts. First, in order to evaluate the CCUS project, a risk indicator system is constructed. In what follows, a decision-making framework for risk assessment under the D numbers environment is proposed, including two stages of decision-making preparation and decision-making process. The main task of the preparation stage is to gather evaluation experts and collect decision-making information. In the decision-making stage, this paper takes the D numbers theory as the core (acting on the effective expression and fusion of subjective evaluation information), respectively, proposes the method of determining the weight of risk evaluators, the fusion method of decision-making information from different experts, and the comprehensive decision model based on the MULTIMOORA method. In order to verify the effectiveness of the constructed model, the case of CCUS project site selection in Shengli power plant is analyzed, and the results showed that the third site is the best option. This study finds the importance of a comprehensive and timely risk assessment for the successful implementation of CCUS projects, and suggests that stakeholders carry out a risk assessment of CCUS projects prior to implementation based on the method presented in this paper, so as to improve the success rate.