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1

Beza, Abebe Dress, Mohammad Maghrour Zefreh, Adam Torok, and Anteneh Afework Mekonnen. "How PTV Vissim Has Been Calibrated for the Simulation of Automated Vehicles in Literature?" Advances in Civil Engineering 2022 (October 26, 2022): 1–18. http://dx.doi.org/10.1155/2022/2548175.

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Recently, in the literature, microscopic simulation is one of the most attractive methods in impact assessment of automated vehicles (AVs) on traffic flow. AVs can be divided into different categories, each having different driving characteristics. Hence, calibrating microscopic simulators for different AV categories could be challenging in AVs’ impact assessment. The PTV Vissim microscopic traffic simulation software has been calibrated for simulating diverse types of AVs in a large body of literature. There are two main streams of studies in literature adapting AVs' driving behaviors in Viss
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Bespalova, T. Yu. "Distribution and genotypic diversity of Listeria monocytogenes strains isolated from humans and ruminants with common clinical and pathological phenotypes (neurolisterioses and abortions) (review)." Agricultural Science Euro-North-East 23, no. 2 (2022): 145–58. http://dx.doi.org/10.30766/2072-9081.2022.23.2.145-158.

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Listeria (L.) monocytogenes is an intracellular food pathogen that causes listeriosis in mammals in the form of sporadic cases or large outbreaks with a high mortality rate among humans and domestic ruminants. The determination of the sequence type (ST) and the clonal complex (CC) by multilocus sequencing (MLST) and other methods in L. monocytogenes strains from different sources allowed us to establish the existence of strains with organ tropism and causing forms of listeriosis common to humans and ruminants. The purpose of the review was to generalize the available data on the distribution a
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Miao, Bei, Hongyu Yao, Peng Chen, and Xue-Jun Song. "Differential Activation of pERK1/2 and c-Fos Following Injury to Different Regions of Primary Sensory Neuron." Life 12, no. 5 (2022): 752. http://dx.doi.org/10.3390/life12050752.

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Nerve injury causes hyperexcitability of the dorsal root ganglion (DRG) and spinal dorsal horn (DH) neurons, which results in neuropathic pain. We have previously demonstrated that partial dorsal rhizotomy (PDR) produced less severe pain-like behavior than chronic constriction injury (CCI) or chronic compression of DRG (CCD) and did not enhance DRG neuronal excitability. However, the mechanisms underlying such discrepancy remain unclear. This study was designed to compare the activation of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) in DRG and DH, and c-Fos in DH followi
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Gregor, Milan, Patrik Grznar, Stefan Mozol, and Lucia Mozolova. "Design of simulation experiments using Central Composite Design." Acta Simulatio 9, no. 2 (2023): 21–25. http://dx.doi.org/10.22306/asim.v9i2.99.

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In the context of research and development, it is key to achieve accurate and reliable results. However, often to obtain these results, a large number of experiments must be performed, which can significantly extend the research time and increase computational requirements. The solution to these problems may be efficient experimental planning, which allows for a reduction in the number of trials and optimization of the process. This article provides an insight into Central Composite Design (CCD) and its use in simulation experiments. We introduce various types of CCD designs, such as CCC (Cent
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Abood, Rafid A., Hasson M. Hasson, Asaad A. Khalaf, and Elaf M. Saleh. "Impact of Comorbidities on Survival Among Patients with Chronic Myeloid Leukaemia Using the Charlson Comorbidity Index: Retrospective study from Basra, Iraq." Sultan Qaboos University Medical Journal [SQUMJ] 19, no. 3 (2019): 236. http://dx.doi.org/10.18295/squmj.2019.19.03.010.

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Objectives: In chronic diseases, comorbidities are known to have a strong negative association with overall survival (OS). This study aimed to use the Charlson Comorbidity Index (CCI) to examine the effect of comorbidities on OS among patients with chronic myeloid leukaemia (CML) treated with tyrosine kinase inhibitors. Methods: This retrospective study was conducted between January 2006 and October 2016 and included 247 CML patients treated at the Basra Oncology & Haematology Centre, Basra, Iraq. Information from hospital records was used to calculate CCI scores and patients were divided
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Li, Y., G. Z. Wang, F. Z. Xuan, and S. T. Tu. "Geometry and Material Constraint Effects on Creep Crack Growth Behavior in Welded Joints." High Temperature Materials and Processes 36, no. 2 (2017): 155–62. http://dx.doi.org/10.1515/htmp-2015-0222.

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AbstractIn this work, the geometry and material constraint effects on creep crack growth (CCG) and behavior in welded joints were investigated. The CCG paths and rates of two kinds of specimen geometry (C(T) and M(T)) with initial cracks located at soft HAZ (heat-affected zone with lower creep strength) and different material mismatches were simulated. The effect of constraint on creep crack initiation (CCI) time was discussed. The results show that there exists interaction between geometry and material constraints in terms of their effects on CCG rate and CCI time of welded joints. Under the
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7

Demb, Joshua, Linn Abraham, Diana L. Miglioretti, et al. "Screening Mammography Outcomes: Risk of Breast Cancer and Mortality by Comorbidity Score and Age." JNCI: Journal of the National Cancer Institute 112, no. 6 (2019): 599–606. http://dx.doi.org/10.1093/jnci/djz172.

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Abstract Background Potential benefits of screening mammography among women ages 75 years and older remain unclear. Methods We evaluated 10-year cumulative incidence of breast cancer and death from breast cancer and other causes by Charlson Comorbidity Index (CCI) and age in the Medicare-linked Breast Cancer Surveillance Consortium (1999–2010) cohort of 222 088 women with no less than 1 screening mammogram between ages 66 and 94 years. Results During median follow-up of 107 months, 7583 were diagnosed with invasive breast cancer and 1742 with ductal carcinoma in situ; 471 died from breast canc
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8

Powell, E. D., T. Asmis, D. Jonker, et al. "Comorbidity and overall survival (OS) in cetuximab-treated patients with advanced colorectal cancer (ACRC)—Results from NCIC CTG CO.17: A phase III trial of cetuximab versus best supportive care (BSC)." Journal of Clinical Oncology 27, no. 15_suppl (2009): 4074. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4074.

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4074 Background: The interplay between comorbidity, age and performance status (PS) as predictors of outcome in ACRC is not well described. We examined these factors as predictors of treatment toxicity and outcome in cetuximab-treated patients with ACRC. Methods: Comorbidity was independently evaluated by 2 physicians using the Charlson Comorbidity Index (CCI), a previously validated measure of comorbidity based on the presence or absence of index medical conditions weighted according to their affect on mortality. CCI score was correlated with demographic data (age, gender), PS, site of primar
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Mullins, C. Daniel, Kaloyan A. Bikov, Ebere Onukwugha, Brian S. Seal, and Nader Hanna. "Frequency of second- and third-line treatment among elderly Medicare stage IV colon cancer patients." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14035-e14035. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14035.

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e14035 Background: Stage IV colon cancer (CC4) patients may receive multiple lines of chemotherapy and/or biologics as treatment (TX) to improve survival or quality of life, yet elderly patients generally receive less aggressive cancer TX. Methods: Elderly (65+) SEER-Medicare patients diagnosed with CC4 in 2003-7 were followed through death or 2009 to examine variation across sub-groups in the number of TX lines. TX included 5-fluorouracil and (levo)leucovorin-based (5FU/LV); irinotecan (IRI) and/or oxaliplatin (OX) with/out 5FU/LV; bevacizumab, cetuximab, or panitumumab (MNCLA), alone or in c
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Mollinedo-Cardalda, Irimia, Karina Pereira, Adriana López-Rodríguez, and José María Cancela-Carral. "Relación entre índices antropométricos y la obesidad en personas mayores de 60 años. Estudios Europeo IN COMMON SPORT." Revista Andaluza de Medicina del Deporte 14, no. 2 (2020): 87–92. http://dx.doi.org/10.33155/j.ramd.2020.08.001.

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Objetivo: Comprobar si el índice de masa corporal (IMC), el índice cintura-cadera (ICC), circunferencia de cintura (CCi), circunferencia de cadera (CCa) y porcentaje de grasa corporal se correlacionan entre sí en personas mayores de 60 años.
 Método: Se realizó un estudio descriptivo correlacional en 1055 personas mayores de 60 años de diferentes países europeos pertenecientes al proyecto europeo IN COMMON SPORTS. Se realizó una valoración inicial de las variables antropométricas.
 Resultados: Correlación significativa del IMC con el porcentaje de grasa corporal, CCi y CCa pero no co
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11

Abdul Rahim, Komal, Bilal Ahmed Usmani, Syed Iqbal Azam, et al. "Infections do not play fair: the Charlson-Age Comorbidity Index reveals sex-specific risk in laparotomy patients in an LMIC." Trauma Surgery & Acute Care Open 10, no. 2 (2025): e001659. https://doi.org/10.1136/tsaco-2024-001659.

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Background Surgical site infections (SSIs) are a major cause of increased morbidity, hospital stay, care costs, and mortality in surgical patients; these can be prognosticated by the Charlson Comorbidity Index (CCI) and accounting for age—the Charlson-Age Comorbidity Index (CACI). Given the limited use of CCI/CACI in low- and middle-income countries, we aimed to assess the use of CCI/CACI in prognosticating the 30-day incidence of SSIs among exploratory laparotomy patients at a tertiary care center in Pakistan. Methods The study analyzed data from adult patients with International Classificati
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Song, Xue-Jun, Carlos Vizcarra, Dong-Sheng Xu, Ronald L. Rupert, and Zheng-Nan Wong. "Hyperalgesia and Neural Excitability Following Injuries to Central and Peripheral Branches of Axons and Somata of Dorsal Root Ganglion Neurons." Journal of Neurophysiology 89, no. 4 (2003): 2185–93. http://dx.doi.org/10.1152/jn.00802.2002.

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We examined thermal hyperalgesia, excitability of dorsal root ganglion (DRG) neurons, and antinociceptive effects of N-methyl-d-aspartate (NMDA) receptor antagonists in rats with injury to different regions of DRG neurons. The central or peripheral branches of axons of DRG neurons were injured by partial dorsal rhizotomy (PDR) and chronic constriction injury of sciatic nerve (CCI), respectively, or the somata injured by chronic compression of DRG (CCD). Thermal hyperalgesia was evidenced by significantly shortened latencies of foot withdrawal to radiant heat stimulation of the plantar surface.
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Pyz-Łukasik, Renata, Waldemar Paszkiewicz, Michał Kiełbus, et al. "Genetic Diversity and Potential Virulence of Listeria monocytogenes Isolates Originating from Polish Artisanal Cheeses." Foods 11, no. 18 (2022): 2805. http://dx.doi.org/10.3390/foods11182805.

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Artisanal cheeses can be sources of Listeria monocytogenes and cause disease in humans. This bacterial pathogen is a species of diverse genotypic and phenotypic characteristics. The aim of the study was to characterize 32 isolates of L. monocytogenes isolated in 2014–2018 from artisanal cheeses. The isolates were characterized using whole genome sequencing and bioinformatics analysis. The artisanal cheese isolates resolved to four molecular groups: 46.9% of them to IIa (1/2a-3a), 31.2% to IVb (4ab-4b-4d-4e), 12.5% to IIc (1/2c-3c), and 9.4% to IIb (1/2b-3b-7). Two evolutionary lineages emerged
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14

Jadhav, Vikas D., Vishwas B. Gaikwad, Ghanshyam B. Jadhav, et al. "Response Surface Methodology (RSM) Approach for Optimization of Parameters for Synthesis of Organic Compounds and Evaluation of Biological Activity with Molecular Docking." Asian Journal of Chemistry 35, no. 5 (2023): 1153–60. http://dx.doi.org/10.14233/ajchem.2023.27593.

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The triazolidine derivatives were synthesized by green and sustainable chemistry approach. The response surface methodology (RSM) was applied to optimize the reaction parameters during the synthesis. Reaction parameter which affect the yield of product were studied, which includes the temperature and time of the reaction. Various statistical RSM with different central composite designs (CCD) such as circumscribed (CCC), face-centered (CCF) and inscribed (CCI) were used to find the maximum yield of the product (%) of reaction at the given parameters and selected, which gave the maximum possible
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15

Kabadi, Shruti V., Bogdan A. Stoica, Kimberly R. Byrnes, Marie Hanscom, David J. Loane, and Alan I. Faden. "Selective CDK Inhibitor Limits Neuroinflammation and Progressive Neurodegeneration after Brain Trauma." Journal of Cerebral Blood Flow & Metabolism 32, no. 1 (2011): 137–49. http://dx.doi.org/10.1038/jcbfm.2011.117.

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Traumatic brain injury (TBI) induces secondary injury mechanisms, including cell-cycle activation (CCA), which lead to neuronal cell death, microglial activation, and neurologic dysfunction. Here, we show progressive neurodegeneration associated with microglial activation after TBI induced by controlled cortical impact (CCI), and also show that delayed treatment with the selective cyclin-dependent kinase inhibitor roscovitine attenuates posttraumatic neurodegeneration and neuroinflammation. CCI resulted in increased cyclin A and D1 expressions and fodrin cleavage in the injured cortex at 6 hou
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Sorbera, L. A., J. Castañer, and M. del Fresno. "CCI-779." Drugs of the Future 27, no. 1 (2002): 7. http://dx.doi.org/10.1358/dof.2002.027.01.654066.

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Md. Shahidul, Islam, Islam Md. Jahirul, Haqu Md. Mansurul, and Nahar Foyzoon. "Household-Level Economic Penalties Resulted From Cci Events Among the Coastal Fishers of Bangladesh." DIU Journal of Health and Life Sciences 7, no. 1 & 2 (2020): 73–84. http://dx.doi.org/10.36481/diuhls.v07i1-2.aa305921.

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Climate change-induced (CCI) calamities have immense negative impacts on coastal fishers’ livelihoods by damaging their household and fishery-related assets, which triggers cyclic poverty among them. This study aimed to identify household-level economic penalties due to CCI calamities among the coastal fishers of Bangladesh. A cross-sectional study was conducted among 338 coastal fishers living in 11 coastal districts using a random sampling technique. Males outnumbered females [84.6% vs. 15.4%], with nearly all (99.1%) living below the poverty line. On average, coastal fishers had to struggle
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*Md., Shahidul Islam Md. Jahirul Islam Md. Mansurul Haque Foyzoon Nahar. "Household -Level Economic Penal Ties Resulted from CCI events Among the Coastal Fishers of Bangladesh." Daffodil International University Journal of Allied Health Sciences. 7, no. 1&2 (2020): 73–84. https://doi.org/10.5281/zenodo.10989875.

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 Climate change-induced (CCI) calamities have immense negative impacts on coastal fishers’ livelihoods by damaging their household and fishery-related assets, which triggers cyclic poverty among them. This study aimed to identify household-level economic penalties due to CCI calamities among the coastal fishers of Bangladesh. A cross-sectional study was conducted among 338 coastal fishers living in 11 coastal districts using a random sampling technique. Males outnumbered females [84.6% vs. 15.4%], with nearly all (99.1%) living below the poverty line. On average, coastal fishers had
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Deguchi, Ryo, Moe Fujimoto, Hiroshi Sekiyama, and Shigehito Sawamura. "Effect of Yokukansan on sleep disturbance and neuropathic pain in chronic constriction injury using a rat model." Sleep and Biological Rhythms 19, no. 3 (2021): 277–83. http://dx.doi.org/10.1007/s41105-021-00315-y.

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AbstractPatients with chronic pain develop peripheral neuropathy and experience sleep disturbance. Yokukansan is used to treat insomnia and control neuropathic pain. We studied if Yokukansan affects neuropathic pain and sleep disturbance using a rat model of chronic constriction injury (CCI). Male Wistar rats (4-week age) were divided into the following groups (n = 7, per group): CCI rats fed normal chow (CCI-0); CCI rats fed powdered chow mixed with 1% Yokukansan (CCI-1); CCI rats fed powdered chow mixed with 3% Yokukansan (CCI-3); and sham-operated control rats fed normal chow (SHAM). We exa
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Lee, Sangmi, Yi Chen, Lisa Gorski, Todd J. Ward, Jason Osborne, and Sophia Kathariou. "Listeria monocytogenesSource Distribution Analysis Indicates Regional Heterogeneity and Ecological Niche Preference among Serotype 4b Clones." mBio 9, no. 2 (2018): e00396-18. http://dx.doi.org/10.1128/mbio.00396-18.

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ABSTRACTBiodiversity analysis of the foodborne pathogenListeria monocytogenesrecently revealed four serotype 4b major hypervirulent clonal complexes (CCs), i.e., CC1, CC2, CC4, and CC6. Hypervirulence was indicated by overrepresentation of these clones, and serotype 4b as a whole, among human clinical isolates in comparison to food. However, data on potential source-dependent partitioning among serotype 4b clones in diverse regions are sparse. We analyzed a panel of 347 serotype 4b isolates, primarily from North America, to determine the distribution of clones in humans, other animals, food, a
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Subraja, Tedy, Lestari Lestari, and Ridha Husla. "ANALISA PENGANGKATAN CUTTING MENGGUNAKAN METODE CCI, CTR DAN CCA PADA SUMUR T TRAYEK 12 ¼"." JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI 7, no. 2 (2022): 220–29. http://dx.doi.org/10.25105/pdk.v7i2.13178.

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Lumpur pemboran merupakan salah satu faktor yang memiliki peranan paling penting selama berlangsungnya operasi pengeboran, maka dari itu perlu untuk mengontrol sifat-sifat fisik dari lumpur pemboran agar sesuai dengan spesifikasi yang diharapkan. Lumpur pengeboran mempunyai fungsi penting dalam operasi pengeboran yaitu mengangkat serbur (cutting) ke permukaan, mencegah runtuhnya dinding lubang bor agar suatu kegiatan pemboran dapat berjalan dengan lancar. Pada tugas akhir ini dilakukan analisa pengangkatan cutting pada sumur T trayek 12 ¼". Metode-metode yang digunakan pada penelitian pengangk
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Subraja, Tedy, Lestari Lestari, Ridha Husla, Apriandi R.R.W, and Ghanima Yasmaniar. "ANALISA PENGANGKATAN CUTTING MENGGUNAKAN METODE CCI, CTR DAN CCA PADA SUMUR T TRAYEK 17 ½”." PETRO:Jurnal Ilmiah Teknik Perminyakan 11, no. 1 (2022): 6–11. http://dx.doi.org/10.25105/petro.v11i1.12794.

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Lumpur pemboran merupakan salah satu faktor yang memiliki peranan paling penting selama berlangsungnya operasi pengeboran, maka dari itu perlu untuk mengontrol sifat-sifat fisik dari lumpur pemboran agar sesuai dengan spesifikasi yang diharapkan. Lumpur pengeboran mempunyai fungsi penting dalam operasi pengeboran yaitu mengangkat serbur (cutting) ke permukaan, mencegah runtuhnya dinding lubang bor agar suatu kegiatan pemboran dapat berjalan dengan lancar. Pada tugas akhir ini dilakukan analisa pengangkatan cutting pada sumur T trayek 17 ½”.Metode-metode yang digunakan pada penelitian pengangka
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Nicholls, Richard, and Marwa Gad Mohsen. "Managing customer-to-customer interaction (CCI) – insights from the frontline." Journal of Services Marketing 33, no. 7 (2019): 798–814. http://dx.doi.org/10.1108/jsm-11-2018-0329.

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Purpose The purpose of this study is to explore the capacity of frontline employees (FLEs) to provide insights into customer-to-customer interaction (CCI) and its management in service organisations. Design/methodology/approach This exploratory study used focus groups and semi-structured in-depth interviews with FLEs to investigate their experiences and reflections in dealing with CCI in a complex service setting in the UK. Findings FLEs are able to recall CCI encounters, both positive (PCCI) and negative (NCCI), with ease. They are capable of conceptualising and exploring complex nuances surr
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Dhakal, Prajwal, Elizabeth Lyden, Avantika Pyakuryal, Manoj P. Rai, and Vijaya Raj Bhatt. "Using Charlson comorbidity index (CCI) to predict outcomes of older patients with acute promyelocytic leukemia (APL)." Journal of Clinical Oncology 40, no. 16_suppl (2022): e18751-e18751. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e18751.

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e18751 Background: A large-scale study specifically analyzing an association between comorbidity burden and outcomes is lacking in APL. We hypothesized that a greater comorbidity burden independently predicts worse outcomes in patients ≥60 years with APL. Methods: We utilized the National Cancer Database to identify patients ≥60 years diagnosed with APL between 2004 and 2015. CCI scores were used to evaluate comorbidity burden, and patients were divided into 3 groups with CCI of 0, 1, and ≥2. We used chi-square test to determine association between CCI and different variables. Multiple logisti
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Dhakal, Prajwal, Elizabeth Lyden, Avantika Pyakuryal, and Vijaya Raj Bhatt. "Predicting early mortality and overall survival (OS) in acute promyelocytic leukemia (APL) based on Charlson comorbidity index (CCI)." Journal of Clinical Oncology 40, no. 16_suppl (2022): e19017-e19017. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e19017.

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e19017 Background: CCI is an established tool used to measure the comorbidity burden in patients, with higher CCI signifying a greater comorbidity burden. We performed a large database analysis to evaluate CCI as a predictor of one-month mortality and OS in patients < 60 years with APL. Methods: Using the National Cancer Database, we identified a total of 4969 patients < 60 years diagnosed with APL between 2004 and 2015. We divided patients into 3 groups with CCI of 0, 1, and ≥2. Multiple regression analysis was used to evaluate the effects of CCI on one-month mortality. Cox regression m
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Yamazaki, Yoko, Masahiro Umino, Haruhisa Fukayama, and Masahiko Shimada. "The Effect of Alternating Current Iontophoresis on Rats with the Chronic Constriction Injury to the Infraorbital Nerve." International Journal of Dentistry 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/405292.

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This study aimed to examine the effect of AC iontophoresis on rats with the chronic constriction injury (CCI) to the infraorbital nerve by animal experiments. CCI model rats were divided into four groups, namely, rats that received general anesthesia for 60 min except AC IOP (CCI:n=5), AC IOP with 0.9% physiological saline for 60 min (CCI + saline AC IOP:n=5), AC IOP with 4% lidocaine hydrochloride for 60 min (CCI + lidocaine AC IOP:n=5), and attachment of two electrodes soaked with 4% lidocaine hydrochloride to the facial skin for 60 min (CCI + attach lidocaine:n=5). In the CCI + lidocaine AC
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Ajibawo, Temitope, Oluwatimilehin Okunowo, and Adeniyi Okunade. "Impact of Comorbidity Burden on Cardiac Implantable Electronic Devices Outcomes." Clinical Medicine Insights: Cardiology 16 (January 2022): 117954682211082. http://dx.doi.org/10.1177/11795468221108212.

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Background: There is limited data on the impact of comorbidity burden on clinical outcomes of patients undergoing cardiac implantable electronic devices (CIED) implantation. Objectives: Our aim was to assess trends in CIED implantations and explore the relationship between comorbidity burden and outcomes in patients undergoing de novo implantations. Methods: Using the National Inpatient Sample database from 2000 to 2014, we identified adults ⩾18 years undergoing de novo CIED procedures. Comorbidity burden was assessed by Charlson comorbidity Index (CCI), and patients were classified into 4 cat
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Yang, Xu, Ke Zhang, Hiba Shaghaleh, et al. "Continuous Cropping Alters Soil Hydraulic and Physicochemical Properties in the Karst Region of Southwestern China." Agronomy 13, no. 5 (2023): 1416. http://dx.doi.org/10.3390/agronomy13051416.

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Continuous cropping causes soil degradation and decreases crop yield in the karst region of southwestern China. However, the relationship between continuous cropping systems and soil hydraulic and physicochemical properties remains incompletely elucidated. In this study, we performed a comparative investigation on the soil physicochemical properties and soil-water-characteristic-curve-derived parameters from sites subjected to 3, 5, or 7 years of continuous cropping (CC3, CC5, and CC7) and cropping rotation (CC0). Soil organic matter content, clay content, and pH were significantly greater in
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Santril, Nitri Ramadhani. "Gambaran Efektivitas Transfusi Thrombocyte Concentrate Pada Pasien Immune Thrombocytopenic Purpura di RSUP Dr. M. Djamil Padang." Majalah Kedokteran Andalas 46, no. 9 (2024): 1440. http://dx.doi.org/10.25077/mka.v46.i9.p1452-1458.2024.

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Latar Belakang: Transfusi trombosit pasien immune thrombocytopenic purpura (ITP) diindikasikan pada kasus ITP dengan perdarahan. Transfusi trombosit pada pasien ITP tidak diikuti dengan peningkatan jumlah trombosit. Corrected count increment (CCI) merupakan penghitungan untuk menilai efektivitas transfusi trombosit. Efektif bila CCI 1 jam pasca transfusi >7,5 x 109/L dan CCI 24 jam >4,5 x 109/L. Tujuan: Mendapatkan gambaran efektivitas transfusi trombosit concentrate (TC) berdasarkan nilai CCI. Metode: Penelitian dilakukan terhadap 31 pasien ITP yang mendapatkan transfusi TC Desember 202
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Ardiansyah, Muhammad, Budi Nugroho, and Khalimatus Sa'diyah. "Estimasi Kadar Klorofil Dan Kadar N Daun Jagung Menggunakan Chlorophyll Content Index." Jurnal Ilmu Tanah dan Lingkungan 24, no. 2 (2022): 53–61. http://dx.doi.org/10.29244/jitl.24.2.53-61.

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Kadar klorofil berkaitan dengan kondisi tanaman, sehingga dapat digunakan untuk menaksir kadar hara pada tanaman. Pengukuran kadar klorofil daun secara konvensional membutuhkan waktu dan biaya, sehingga perlu dikembangkan teknologi yang cepat dan efisien. Penelitian ini bertujuan untuk (a) menganalisa indek kadar klorofil (Chlorofil Content Index, CCI) dan kadar klorofil daun pada 10 perlakuan dosis pupuk termasuk kontrol dan beberapa fase pertumbuhan jagung, (b) menganalisa hubungan antara CCI dan kadar klorofil daun, dan (c) menganalisa hubungan CCI dan kadar N. Pada penelitian ini CCI diuku
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Enenkel, Markus, Christoph Reimer, Wouter Dorigo, et al. "Combining satellite observations to develop a global soil moisture product for near-real-time applications." Hydrology and Earth System Sciences 20, no. 10 (2016): 4191–208. http://dx.doi.org/10.5194/hess-20-4191-2016.

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Abstract. The soil moisture dataset that is generated via the Climate Change Initiative (CCI) of the European Space Agency (ESA) (ESA CCI SM) is a popular research product. It is composed of observations from 10 different satellites and aims to exploit the individual strengths of active (radar) and passive (radiometer) sensors, thereby providing surface soil moisture estimates at a spatial resolution of 0.25°. However, the annual updating cycle limits the use of the ESA CCI SM dataset for operational applications. Therefore, this study proposes an adaptation of the ESA CCI product for daily gl
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Hayashi, Ken, Tatsuhiko Sato, Motoaki Yoshida, and Koichi Yoshimura. "Corneal shape changes of the total and posterior cornea after temporal versus nasal clear corneal incision cataract surgery." British Journal of Ophthalmology 103, no. 2 (2018): 181–85. http://dx.doi.org/10.1136/bjophthalmol-2017-311710.

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AimTo compare changes in the shape and astigmatism of the total and posterior cornea between eyes with a nasal clear corneal incision (CCI) and eyes with a temporal CCI in cataract surgery.MethodsThe left eyes of 100 patients undergoing phacoemulsification were randomly assigned to undergo a 2.4 mm nasal (nasal CCI group) or temporal CCI (temporal CCI group). Corneal astigmatic changes were compared between groups using power vector analysis, and corneal shape changes were compared using videokeratography maps at 2 days, and at 2, 4 and 8 weeks postoperatively.ResultsThe mean J0 and J45 values
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Jenni-Moser, Béatrice, and Marie-Madlen Jeitziner. "CCI – ein Resümee." intensiv 24, no. 01 (2016): 14–15. http://dx.doi.org/10.1055/s-0041-107570.

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Thenjiwe Sithole, Jaco Du Toit, and Sebastian Von Solms. "A Cyber Counterintelligence Competence Framework: Developing the Job Roles." European Conference on Cyber Warfare and Security 22, no. 1 (2023): 450–57. http://dx.doi.org/10.34190/eccws.22.1.1093.

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In recent years, there have been intensifying cyber risks and volumes of cyber incidents prompting a significant shift in the cyber threat landscape. Both nation-state and non-state actors are increasingly resolute and innovative in their techniques and operations globally. These intensifying cyber risks and incidents suggest that cyber capability is inversely proportional to cyber risks, threats and attacks. Therefore, this confirms an emergent and critical need to adopt and invest in intelligence strategies, predominantly cyber counterintelligence (CCI), which is a multi-disciplinary and pro
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Enenkel, M., C. Reimer, W. Dorigo, et al. "Combining satellite observations to develop a daily global soil moisture product for a wide range of applications." Hydrology and Earth System Sciences Discussions 12, no. 11 (2015): 11549–89. http://dx.doi.org/10.5194/hessd-12-11549-2015.

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Abstract. The soil moisture dataset that is generated via the Climate Change Initiative (CCI) of the European Space Agency (ESA) (ESA CCI SM) is a popular research product. It is composed of observations from nine different satellites and aims to exploit the individual strengths of active (radar) and passive (radiometer) sensors, thereby providing surface soil moisture estimates at a spatial resolution of 0.25°. However, the annual updating cycle limits the use of the ESA CCI SM dataset for operational applications. Therefore, this study proposes an adaptation of the ESA CCI processing chain f
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Sasagawa, Taiga, Tomoko Kawaguchi Akitsu, Reiko Ide, et al. "Accuracy Assessment of Photochemical Reflectance Index (PRI) and Chlorophyll Carotenoid Index (CCI) Derived from GCOM-C/SGLI with In Situ Data." Remote Sensing 14, no. 21 (2022): 5352. http://dx.doi.org/10.3390/rs14215352.

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The photochemical reflectance index (PRI) and the chlorophyll carotenoid index (CCI) are carotenoid-sensitive vegetation indices, which can monitor vegetation’s photosynthetic activities. One unique satellite named “Global Change Observation Mission-Climate (GCOM-C)” is equipped with a sensor, “Second Generation Global Imager (SGLI)”, which has the potential to frequently and simultaneously observe PRI and CCI over a wide swath. However, the observation accuracy of PRI and CCI derived from GCOM-C/SGLI remains unclear in forests. Thus, we demonstrated their accuracy assessment by comparing them
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37

Dong, Zhiqiang, Yong Sun, Peihua Lu, Yanqing Wang, and Gencheng Wu. "Electroacupuncture and Lumbar Transplant of GDNF-Secreting Fibroblasts Synergistically Attenuate Hyperalgesia after Sciatic Nerve Constriction." American Journal of Chinese Medicine 41, no. 03 (2013): 459–72. http://dx.doi.org/10.1142/s0192415x1350033x.

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Electroacupuncture (EA) has been shown to induce potent analgesic effects on neuropathic pain in both patients and rodents. Cell therapy to release antinociceptive agents near the pain processing centers of the spinal cord is a promising next step in the development of treatment modalities. This study investigated the effects of the combination of EA and cell therapy by glial cell line-derived neurotrophic factor (GDNF) on neuropathic pain in rats. The hyperalgesic state was induced by chronic constriction injury (CCI) of the sciatic nerve and fibroblasts genetically modified to secrete bioact
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38

Goyal, Jatinder, Gregory Russell Pond, Matt D. Galsky, et al. "Study of the impact of Charlson comorbidity index and hypertension on survival in patients with metastatic castration-resistant prostate cancer." Journal of Clinical Oncology 31, no. 6_suppl (2013): 111. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.111.

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111 Background: Clinical and laboratory factors, i.e. visceral metastasis, anemia, LDH, PSA, PSA-doubling time, bone scan progression, pain, performance status (PS), are recognized to be prognostic factors for overall survival (OS) in metastatic castration resistant prostate cancer (mCRPC). We sought to determine if the Charlson comorbidity Index (CCI) and hypertension (HTN) provide prognostic information independent of these known factors. Methods: We retrospectively evaluated 221 patients with mCRPC treated with docetaxel plus prednisone (DP) combined with AT-101 (bcl-2 antagonist) or placeb
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39

Yang, Yan, Cody Cox, and YoonJung Cho. "Development and Initial Validation of Cultural Competence Inventory–Preservice Teachers." Journal of Psychoeducational Assessment 38, no. 3 (2019): 305–20. http://dx.doi.org/10.1177/0734282919848890.

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Despite the critical role of emotions in multicultural teacher education, no attempt has been made to develop an instrument including affect as a dimension in measuring cultural competence for preservice teachers. To bridge this gap, the present three-study research used three distinct samples of 456 preservice teachers to develop and estimate the reliability of scores and validity of inferences for Cultural Competence Inventory–Preservice Teachers (CCI-PT), an 18-item instrument including three subscales: emotional cultural competence (ECC), behavioral cultural competence (BCC), and cognitive
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40

Ofori-Asenso, Richard, Ella Zomer, Ken Chin, et al. "Effect of Comorbidity Assessed by the Charlson Comorbidity Index on the Length of Stay, Costs and Mortality among Older Adults Hospitalised for Acute Stroke." International Journal of Environmental Research and Public Health 15, no. 11 (2018): 2532. http://dx.doi.org/10.3390/ijerph15112532.

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The burden of comorbidity among stroke patients is high. The aim of this study was to examine the effect of comorbidity on the length of stay (LOS), costs, and mortality among older adults hospitalised for acute stroke. Among 776 older adults (mean age 80.1 ± 8.3 years; 46.7% female) hospitalised for acute stroke during July 2013 to December 2015 at a tertiary hospital in Melbourne, Australia, we collected data on LOS, costs, and discharge outcomes. Comorbidity was assessed via the Charlson Comorbidity Index (CCI), where a CCI score of 0–1 was considered low and a CCI ≥ 2 was high. Negative bi
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Cheng, Kuang-I., Yu-Chin Chang, Li-Wen Chu, et al. "The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain." International Journal of Molecular Sciences 23, no. 24 (2022): 15873. http://dx.doi.org/10.3390/ijms232415873.

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Autophagy facilitates the degradation of organelles and cytoplasmic proteins in a lysosome-dependent manner. It also plays a crucial role in cell damage. Whether loganin affects autophagy in chronic constriction injury (CCI)-induced neuropathic pain remains unclear. We investigated the neuroprotective effect of loganin on the autophagic–lysosomal pathway in the rat CCI model. Sprague–Dawley rats were divided into sham, CCI, sham + loganin, and CCI + loganin. Loganin (5 mg/kg/day) was intraperitoneally injected once daily, and rats were sacrificed on day 7 after CCI. This study focused on the m
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Cheng, Kuang-I., Kan-Ting Yang, Chien-Lun Kung, et al. "BKCa Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia." Cells 10, no. 4 (2021): 949. http://dx.doi.org/10.3390/cells10040949.

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This study explored whether KMUP-1 improved chronic constriction injury (CCI)-induced BKCa current inhibition in dorsal root ganglion (DRG) neurons. Rats were randomly assigned to four groups: sham, sham + KMUP-1, CCI, and CCI + KMUP-1 (5 mg/kg/day, i.p.). DRG neuronal cells (L4–L6) were isolated on day 7 after CCI surgery. Perforated patch-clamp and inside-out recordings were used to monitor BKCa currents and channel activities, respectively, in the DRG neurons. Additionally, DRG neurons were immunostained with anti-NeuN, anti-NF200 and anti-BKCa. Real-time PCR was used to measure BKCa mRNA l
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Wheeler, Meghann, Shama D. Karanth, Hiren J. Mehta, et al. "Survival Differences by Comorbidity Burden among Patients with Stage I/II Non-Small-Cell Lung Cancer after Thoracoscopic Resection." Cancers 15, no. 7 (2023): 2075. http://dx.doi.org/10.3390/cancers15072075.

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We sought to compare overall survival (OS) by comorbidity burden among patients with stage I/II non-small cell lung cancer (NSCLC) who received thoracoscopic resection. Utilizing data from the National Cancer Database, we conducted a survival analysis among patients aged 50+ with stage I/II NSCLC who received thoracoscopic resection between 2010 and 2017. The comorbidity burden was measured by the Charlson comorbidity index (CCI, 0, 1, 2+). Multivariable Cox proportional hazard models were used to compare overall survival relative to the CCI (CCI of 0 as the referent). Subgroup analyses were c
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Kalinin, Egor V., Yaroslava M. Chalenko, Polina V. Safarova, Victoria A. Fedorova, and Svetlana A. Ermolaeva. "Analysis of production levels of InlA and InlB invasion factors in Listeria monocytogenes isolates collected in the Russian Federation." Journal of microbiology, epidemiology and immunobiology 100, no. 5 (2023): 276–86. http://dx.doi.org/10.36233/0372-9311-397.

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Background. Listeria monocytogenes is characterized by the presence of epidemic hypervirulent clones. A key feature of L. monocytogenes is its capacity to invade non-professional phagocytic cells. Hypervirulent clones are strongly associated with the increased production and/or the presence of certain isoforms of invasion factors InlA and InlB.
 The purpose of the study is to create a test system for InlA and InlB detection and to measure the InlA and InlB production levels in L. monocytogenes isolates belonging to clonal groups with different virulence potential.
 Materials and meth
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Peixoto, Jennifer Granja, Alessandra Germano Dias, Laís Maini Miranda, Érica Cesário Defilipo, Manuella Barbosa Feitosa, and Paula Silva de Carvalho Chagas. "Análise de confiabilidade de medidas das pressões plantares estática e dinâmica de crianças e adolescentes com desenvolvimento normal." Fisioterapia e Pesquisa 24, no. 1 (2017): 46–53. http://dx.doi.org/10.1590/1809-2950/16222224012017.

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RESUMO A pressão plantar é utilizada na avaliação clínica do pé e informa características da distribuição de carga plantar em atividades funcionais. Diversos instrumentos de avaliação podem ser utilizados e devem ter as propriedades psicométricas analisadas. A confiabilidade teste-reteste é uma medida de reprodutibilidade. O objetivo deste estudo foi analisar a confiabilidade teste-reteste das medidas de pressão máxima na estática e dinâmica de crianças e adolescentes com desenvolvimento normal (DN). Onze crianças e adolescentes com DN, de ambos os sexos, com idade entre 6 e 17 anos foram aval
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46

Kristoffersen, Malfrid H., Eva H. Dybvik, Ole M. Steihaug, et al. "Patient-reported outcome measures after hip fracture in patients with chronic cognitive impairment." Bone & Joint Open 2, no. 7 (2021): 454–65. http://dx.doi.org/10.1302/2633-1462.27.bjo-2021-0058.r1.

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Aims Hip fracture patients have high morbidity and mortality. Patient-reported outcome measures (PROMs) assess the quality of care of patients with hip fracture, including those with chronic cognitive impairment (CCI). Our aim was to compare PROMs from hip fracture patients with and without CCI, using the Norwegian Hip Fracture Register (NHFR). Methods PROM questionnaires at four months (n = 34,675) and 12 months (n = 24,510) after a hip fracture reported from 2005 to 2018 were analyzed. Pre-injury score was reported in the four-month questionnaire. The questionnaires included the EuroQol five
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47

Fu, Huiqun, Fenghua Li, Sebastian Thomas, and Zhongjin Yang. "Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord." Scandinavian Journal of Pain 17, no. 1 (2017): 330–38. http://dx.doi.org/10.1016/j.sjpain.2017.08.014.

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AbstractBackground and aimsDysfunction of GABAergic inhibitory controls contributes to the development of neuropathic pain. We examined our hypotheses that (1) chronic constriction injury (CCI)-induced neuropathic pain is associated with increased spinal GABAergic neuron apoptosis, and (2) hyperbaric oxygen therapy (HBO) alleviates CCI-induced neuropathic pain by inhibiting GABAergic neuron apoptosis.MethodsMale rats were randomized into 3 groups: CCI, CCI+HBO and the control group (SHAM). Mechanical allodynia was tested daily following CCI procedure. HBO rats were treated at 2.4 atmospheres a
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Xu, Zhaomin, Carla Francesca Justiniano, Adan Z. Becerra, et al. "Surgeon and hospital variation in adjuvant chemotherapy delivery to patients with stage III colon cancer." Journal of Clinical Oncology 35, no. 15_suppl (2017): 3596. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.3596.

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3596 Background: It is well established that age and comorbidities have significant impact on adjuvant chemotherapy delivery to stage III colon cancer patients. This study examines differences in the hospital and surgeon-specific probabilities of adjuvant therapy delivery to stage III colon cancer patients by comorbidity burden and age. Methods: Patients who underwent surgery for stage III colon cancer from 2004-2013 were included from the New York State Cancer Registry and the Statewide Planning and Research Cooperative System. Comorbidity burden was defined with the Charlson Comorbidity Inde
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Wong, Melisa L., Timothy L. McMurry, Jessica R. Schumacher, et al. "Comorbidity Assessment in the National Cancer Database for Patients With Surgically Resected Breast, Colorectal, or Lung Cancer (AFT-01, -02, -03)." Journal of Oncology Practice 14, no. 10 (2018): e631-e643. http://dx.doi.org/10.1200/jop.18.00175.

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Purpose: Accurate comorbidity measurement is critical for cancer research. We evaluated comorbidity assessment in the National Cancer Database (NCDB), which uses a code-based Charlson-Deyo Comorbidity Index (CCI), and compared its prognostic performance with a chart-based CCI and individual comorbidities in a national sample of patients with breast, colorectal, or lung cancer. Patients and Methods: Through an NCDB Special Study, cancer registrars re-abstracted perioperative comorbidities for 11,243 patients with stage II to III breast cancer, 10,880 with stage I to III colorectal cancer, and 9
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Yang, Hua, Limin Meng, Shuanli Xin, Chao Chang, Xiufeng Zhao, and Bingyan Guo. "Association of age-adjusted Charlson comorbidity index with adverse outcomes in patients undergoing transcatheter aortic valve replacement: A retrospective cohort study." Medicine 102, no. 47 (2023): e36283. http://dx.doi.org/10.1097/md.0000000000036283.

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Patients undergoing transcatheter aortic valve replacement (TAVR) have a high comorbid burden. Our objective was to assess the association between the age-adjusted Charlson comorbidity index (Age-CCI) and mortality and readmission rates within 1-year post-TAVR. Data were extracted from the Medical Information Mart for Intensive Care IV database (MIMIC-IV version 2.0). The primary endpoint was a composite outcome of all-cause mortality or readmission within 1-year after TAVR. To examine the associations of Age-CCI with outcomes, we used multivariable Cox proportional hazards regression, restric
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