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Ghi, Maria Grazia, Adriano Paccagnella, Daris Ferrari, Paolo Foa, Franco Nole, Franco Morelli, Giuseppe Azzarello, et al. "Cetuximab/radiotherapy (CET+RT) versus concomitant chemoradiotherapy (cCHT+RT) with or without induction docetaxel/cisplatin/5-fluorouracil (TPF) in locally advanced head and neck squamous cell carcinoma (LASCCHN): Preliminary results on toxicity of a randomized, 2x2 factorial, phase II-III study (NCT01086826)." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 5513. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.5513.
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5513 Background: The standard treatment options for LASCCHN are cCHT+RT or CET+RT. Strategies to improve the efficacy with the integration of induction chemotherapy are being investigated. Primary endpoints of this study were to compare: 1) the overall survival (OS) of induction vs. no induction arms; 2) the Grade(G)3-4 in-field toxicity of cCHT+RT vs. CET+RT. Methods: Patients (pts) with unresectable LASCCHN, stage III-IV, ECOG PS 0–1 were randomized to a 2x2 factorial design: Arm A1: cCHT+RT (2 cycles of ciplatin/5fluorouracil); Arm A2: CET+RTX; Arm B1: 3 cycles of TPF followed by the same cCHT+RT; Arm B2: 3 cycles of TPF followed by CET+RT. A total of 204 deaths over 420 pts ( including the 101 randomized in the phase II part of the study comparing cCHT+RT with or w/o induction TPF) were required to detect a HR of death of 0.675 (A1+A2 vs. B1+B2; 2-sided a=0.05; b=0.20) and a 10% difference in G3-4 in-field mucosal toxicity (A1+B1 vs. A2+B2). Results: By February 2012, 387 pts over 413 pts were evaluable for toxicity. 82% of pts were male; median age was 60y; PS: 0=77.8% and 1=22.2%. Disease stage was III (31%) or IV (69%). Sites of disease were oral cavity (21.7%), oropharynx (54.8%), hypopharynx (23.5%). At a median follow-up of 21 months, 126 deaths occurred. Data on G3-4 in-field toxicity (primary endpoint) and compliance to cCHT+RT vs CET+RT are shown in the table. Conclusions: No advantage for CET+RT over cCHT+RT was observed regarding G3-4 in-field toxicities and feasibility. Pts are still being followed-up to assess OS. [Table: see text]
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Tasic, Lidija, Radica Dunjic, Mladenko Vasiljevic, Svetlana Dikic, Aleksandar Jurisic, and Dijana Tasic. "Comparison of two different types of hormone therapy effects on haemostatic parameters in early postmenopausal women." Srpski arhiv za celokupno lekarstvo 139, no. 1-2 (2011): 52–57. http://dx.doi.org/10.2298/sarh1102052t.
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Introduction. Most postmenopausal women have some of menopausal symptoms due to oestrogen deprivation. Many therapeutic options are available for managing menopausal problems. However, hormone therapy is associated with a heightened risk for thromboembolic events. Objective. To investigate the effects of different types of hormone therapy on some haemostatic parameters. Methods. This randomized, controlled study included 56 healthy, early postmenopausal women aged 46-58 years on different types of hormone therapy (tibolone 2.5 mg/day, 25 women, or CCHT 2 mg estradiol plus 1 mg norethisteron acetate, 31 women) and 20 healthy postmenopausal women of the same age receiving placebo. Effects of these 2 medicaments on some haemostasis parameters were measured 3 and 6 months after the onset of treatment. Results. Short-term use (3 months) of both tibolone and CCHT had a detrimental effect on antithrombin, protein C and protein S levels (decreased), and even more so in the group treated with CCHT. Plasminogen-activator inhibitor type 1 levels were decreased by both tibolone and CCHT, but more so by CCHT; thrombin-antithrombin complex were increased in both groups. There were no changes in haemostatic parameters between 3-month and 6-month treatment in any group. Conclusion. Both therapeutic options are associated with an activation of thrombogenic and fibrinolytic markers within 3 months of use. Tibolone appears to produce a better balance between thrombogenesis and fibrinolysis. Since our results show a lower incidence of thrombotic events, further studies are required.
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Musteata, Vasile, Lilian Nichifor, Larisa Musteata, and Galina Durbailova. "Diagnosis Issues and Management of Nasopharyngeal Non-Hodgkin Lymphomas." Blood 138, Supplement 1 (November 5, 2021): 4588. http://dx.doi.org/10.1182/blood-2021-144340.
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Abstract Background: Non-Hodgkin lymphomas (NHL) comprise a variety of lymphoproliferative malignancies with certain differences related to the morphological, clinical, immunohistochemical and hematological patterns, as well as the results of treatment. The patients with generalized and relapsed nasopharyngeal NHL experience marked disease burden and unfavorable impact on their life quality and working capacity. Objective: The aim of the study was to characterize the diagnosis issues of NHL with primary involvement of the nasopharynx and evaluate the short- and long-term results of management options. Materials and methods: This analytical and cohort study included 66 patients with different stages of nasopharyngeal NHL, who were managed at the Institute of Oncology from Moldova between 2014-2021. The diagnosis was confirmed by cytological, histopathological and immunohistochemical examinations. The histological types of NHL were verified and distinguished according to the 2017 Revision of WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. The patients treatment, follow-up and researches were realized at the comprehensive cancer center. The study was related to the hospitalized care. The patients age ranged between 19-85 years (average age - 58.4±2,14 years). Males were 28 (42%), females - 38 (58%). Stage I NHL was diagnosed in 10 (15.2%) cases, stage II - in 36 (54.5%), stage III - in 8 (12.1%) and stage IV - in 12 (18.2%). The eligible NHL patients underwent combined chemotherapy (CChT) regimens (CVChlP, R-CVChlP, CHOP and R-CHOP), associated with radiotherapy locoregional treatment in cases of bulky disease or residual tumor masses. The ECOG-WHO score and complete response (CR) rate assessed the short-term results. The long-term results were asserted by the overall one- and 5-year survival. Results: Primary nasopharyngeal NHL occurred commonly in females (58%) and in patients over 60 years (42.4%). The ECOG-WHO score accounted 1-3 at diagnosis. The aggressive NHL were diagnosed mostly (76.1%) in stage I and II due to the earlier developed disease burden. The primary tumor site was localized in the palatine tonsils in 22 (33.3%) patients, in 33 (50%) patients in the pharyngeal tonsil, in 2 (3%) patients in the lingual tonsil. The palatine and pharyngeal tonsils were concomitantly involved in 9 (13.7%) patients. Palatine tonsil involvement occurred mostly in patients over 60 years old, and pharyngeal tonsil involvement - in patients of 40-59 years. CR was achieved in 10 (100%) cases with stage I after combined chemotherapy (CChT) and radiotherapy locoregional treatment. CR occurred in 21 (67.7%), partial response (PR) - in 7 (22.6%) and response failure (RF) - in 3 (9.7%) in stage II NHL after CChT and radiotherapy locoregional treatment. In stage II NHL treated with CChT along, CR was achieved in 1 (25%), PR - in 2 (50%) and RF in 1 (25%). In stage III treated with CChT and radiotherapy locoregional treatment, CR was registered in 1 (20%), PR - in 2 (40%) and RF - in 2 (40%). PR occurred in 2 (66.7%), RF - in 1 (33.3%) in stage III managed with CChT alone. In stage IV NHL, CR was obtained 1 (11.1%) case, PR - in 5 (55.6%), RF - in 3 (33.3%) after CChT and radiotherapy locoregional treatment. PR occurred in 1 (33.3%), RF - in 2 (66.7%) cases in stage IV patients managed with CChT alone. No significant differences of CR rate were found in stage III (12,5%) and stage IV (8.3%) NHL (P>0.05). Irrespective of the stage, the highest CR rate was registered after CChT and radiotherapy locoregional treatment (97.1% of all cases), as compared to CChT alone (2.9% of all cases). The ECOG-WHO score reached 0-1 under the management with CChT and radiotherapy locoregional treatment in all cases with CR and PR. The overall survival was 79.9% at one year and 34.5% at 5 years. One- and 5-year survival proved to be significantly higher în stage I and II NHL - 96.1% and 64.2% respectively. One- and 5-year survival was 79.9% and 34.5% in stage III and IV NHL. Conclusions: Primary nasopharyngeal NHL were outlined by the predominant involvement of females, patients over 60 years and frequent site in the pharyngeal tonsil. The aggressive NHL were revealed commonly in stage I and II due to the progressive disease burden. The rates of the indolent and aggressive NHL turned out to be statistically equal in stage III and IV. The response and overall survival rates proved to be superior after R-CHOP regimen followed by the radiotherapy locoregional treatment. Disclosures No relevant conflicts of interest to declare.
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Barnett, Tracey E., Neale R. Chumbler, W. Bruce Vogel, Rebecca J. Beyth, Patricia Ryan, and Sarita Figueroa. "The cost-utility of a care coordination/home telehealth programme for veterans with diabetes." Journal of Telemedicine and Telecare 13, no. 6 (September 1, 2007): 318–21. http://dx.doi.org/10.1258/135763307781644843.
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We examined the cost-effectiveness of a care coordination/home telehealth (CCHT) programme for veterans with diabetes. We conducted a retrospective, pre-post study which compared data for a cohort of veterans ( n=370) before and after the introduction of the CCHT programme for two periods of 12 months. To assess the cost-effectiveness, we converted the patients' health-related quality of life data into Quality Adjusted Life Year (QALY) utility scores and used costs to construct incremental cost-effectiveness ratios (ICERs). The overall mean ICER for the programme at one-year was $60,941, a value within the commonly-cited range of cost-effectiveness of $50,000–100,000. The programme was cost-effective for one-third of the participants. Characteristics that contributed to cost-effectiveness were marital status, location and clinically relevant co-morbidities. By targeting the intervention differently in future work, it may become cost-effective for a greater proportion of patients.
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Torelli, P., D. Cologno, C. Cademartiri, and GC Manzoni. "Primary and Secondary Chronic Cluster Headache: Two Separate Entities?" Cephalalgia 20, no. 9 (November 2000): 826–29. http://dx.doi.org/10.1046/j.1468-2982.2000.00127.x.
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The International Headache Society (IHS) classification divides chronic cluster headache (CH) into two subtypes: chronic CH unremitting from onset (CCHU) and chronic CH evolved from episodic (CCHE). The purpose of our study was to point out any similarities and differences between the two chronic CH subtypes and to determine whether or not they can be considered as two separate clinical entities. We reviewed data about 31 CCHE patients and 38 CCHU patients referred to the Parma Headache Centre between 1975 and 1999. Clinically, CCHE patients exhibited statistically significant differences from CCHU patients, i.e. earlier CH onset and duration of attacks varying more frequently between 120 and 180 min. From the point of view of lifestyle, heavy alcohol and coffee drinkers prevailed among CCHU patients, while CCHE patients were more frequently heavy smokers. Based on clinical features, it seems reasonable to suppose that chronic CH may occur as two distinct entities.
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Kumar, Raman, and Nonika Singla. "Cryptanalytic Performance Appraisal of Improved CCH2 Proxy Multisignature Scheme." Mathematical Problems in Engineering 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/429271.
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Many of the signature schemes are proposed in which thetout ofnthreshold schemes are deployed, but they still lack the property of security. In this paper, we have discussed implementation of improved CCH1 and improved CCH2 proxy multisignature scheme based on elliptic curve cryptosystem. We have represented time complexity, space complexity, and computational overhead of improved CCH1 and CCH2 proxy multisignature schemes. We have presented cryptanalysis of improved CCH2 proxy multisignature scheme and showed that improved CCH2 scheme suffered from various attacks, that is, forgery attack and framing attack.
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Afzali, Sayed Fakhreddin, Bijan Azad, Mohammad H. Golabi, and Rosa Francaviglia. "Using RothC Model to Simulate Soil Organic Carbon Stocks under Different Climate Change Scenarios for the Rangelands of the Arid Regions of Southern Iran." Water 11, no. 10 (October 10, 2019): 2107. http://dx.doi.org/10.3390/w11102107.
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Soil organic carbon (SOC) is strongly influenced by climate change, and it is believed that increased temperatures might enhance the release of CO2 with higher emission into the atmosphere. Appropriate models may be used to predict the changes of SOC stock under projected future scenarios of climate change. In this investigation, the RothC model was run for a period of 36 years under climate scenarios namely: P (no climate change) as well as CCH1 and CCH2 (climate change scenarios) in the arid rangelands of Ghir–O-Karzin’s BandBast in southern Iran. Model results have shown that after 11 years (2014–25), SOC stock decreased by 3.05% under the CCH1 scenario (with a projected annual precipitation decrease by 6.69% and mean annual temperature increase by 9.96%) and by 0.23% under the P scenario. In CCH2, with further decreases in rainfall (10.93%) and increase in temperature (12.53%) compared to CCH1, the model predicted that the SOC stock during the 25 years (2025–50) was reduced by 2.36% and 3.53% under the CCH1 and CCH2 scenario respectively. According to model predictions, with future climatic conditions (higher temperatures and lower rainfall) the decomposition rate may increase resulting in higher losses of soil organic carbon from the soil matrix. The result from this investigation may also be used for developing management techniques to be practiced in the other arid rangelands of Iran with similar conditions.
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Yoo, Yeong, Yousef Al-Shawesh, and Alain Tchagang. "Coordinated Control Strategy and Validation of Vehicle-to-Grid for Frequency Control." Energies 14, no. 9 (April 28, 2021): 2530. http://dx.doi.org/10.3390/en14092530.
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The increased penetration of renewable energy sources (RES) and electric vehicles (EVs) is resulting in significant challenges to the stability, reliability, and resiliency of the electrical grid due to the intermittency nature of RES and uncertainty of charging demands of EVs. There is a potential for significant economic returns to use vehicle-to-grid (V2G) technology for peak load reduction and frequency control. To verify the effectiveness of the V2G-based frequency control in a microgrid, modeling and simulations of single- and multi-vehicle-based primary and secondary frequency controls were conducted to utilize the integrated components at the Canadian Centre for Housing Technology (CCHT)-V2G testing facility by using MATLAB/Simulink. A single-vehicle-based model was validated by comparing empirical testing and simulations of primary and secondary frequency controls. The validated conceptual model was then applied for dynamic phasor simulations of multi-vehicle-based frequency control with a proposed coordinated control algorithm for improving frequency stability and facilitating renewables integration with V2G-capable EVs in a microgrid. This proposed model includes a decentralized coordinated control of the state of charge (SOC) and charging schedule for five aggregated EVs with different departure times and SOC management profiles preferred by EV drivers. The simulation results showed that the fleet of 5 EVs in V2B/V2G could effectively reduce frequency deviation in a microgrid.
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Guo, Jianhui, Tiyun Wu, Bradley F. Kane, Donald G. Johnson, Louis E. Henderson, Robert J. Gorelick, and Judith G. Levin. "Subtle Alterations of the Native Zinc Finger Structures Have Dramatic Effects on the Nucleic Acid Chaperone Activity of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein." Journal of Virology 76, no. 9 (May 1, 2002): 4370–78. http://dx.doi.org/10.1128/jvi.76.9.4370-4378.2002.
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ABSTRACT The nucleocapsid protein (NC) of human immunodeficiency virus type 1 has two zinc fingers, each containing the invariant CCHC zinc-binding motif; however, the surrounding amino acid context is not identical in the two fingers. Recently, we demonstrated that zinc coordination is required when NC unfolds complex secondary structures in RNA and DNA minus- and plus-strand transfer intermediates; this property of NC reflects its nucleic acid chaperone activity. Here we have analyzed the chaperone activities of mutants having substitutions of alternative zinc-coordinating residues, i.e., CCHH or CCCC, for the wild-type CCHC motif. We also investigated the activities of mutants that retain the CCHC motifs but have mutations that exchange or duplicate the zinc fingers (mutants 1-1, 2-1, and 2-2); these changes affect amino acid context. Our results indicate that in general, for optimal activity in an assay that measures stimulation of minus-strand transfer and inhibition of nonspecific self-priming, the CCHC motif in the zinc fingers cannot be replaced by CCHH or CCCC and the amino acid context of the fingers must be conserved. Context changes also reduce the ability of NC to facilitate primer removal in plus-strand transfer. In addition, we found that the first finger is a more crucial determinant of nucleic acid chaperone activity than the second finger. Interestingly, comparison of the in vitro results with earlier in vivo replication data raises the possibility that NC may adopt multiple conformations that are responsible for different NC functions during virus replication.
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Venturini, R. S., S. Carvalho, C. C. Pires, P. S. Pacheco, A. C. R. S. Pellegrin, A. B. Moro, J. F. Lopes, et al. "Consumo e desempenho de cordeiros e borregos alimentados com dietas de alto concentrado de milho ou sorgo." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 68, no. 6 (December 2016): 1638–46. http://dx.doi.org/10.1590/1678-4162-8856.
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RESUMO Objetivou-se avaliar os consumos de matéria seca, nutrientes e desempenho na terminação de cordeiros e borregos submetidos a dietas de alto concentrado de grão de milho ou sorgo. Foram utilizados 32 animais, sendo 16 cordeiros (dente de leite) e 16 borregos (dois dentes) da raça Corriedale. As dietas eram constituídas de feno de aveia- branca (Avena sativa), grão de milho (Zea mays) ou de sorgo (Sorghum bicolor (L.) Moench), farelo de soja (Glycine Max), calcário calcítico, bicarbonato de sódio e monensina. Os cordeiros apresentaram superioridade (P≤0,05) quanto ao CMS (% do PV e g/kg PV0,75), ao CPB (kg/dia, % do PV e g/kg PV0,75), ao CEE (% do PV), ao CFDN e ao CFDA (% do PV e g/kg PV0,75), ao CNDT (% do PV), ao ganho de peso médio diário, à conformação in vivo e à conversão alimentar. Por outro lado, o CEE, o CCHT e o CCNE (kg/dia), o peso vivo inicial, o peso vivo final e o peso vivo ao abate foram superiores (P≤0,05) na categoria dos borregos. Em relação aos grãos avaliados, verificou-se maior (P≤0,05) CEE (kg/dia, % do PV e g/kg PV0,75) e menor (P≤0,05) CFDN (% do PV) e CFDA (kg/dia, % do PV e g/kg PV0,75) para os animais alimentados com dieta de alto concentrado à base de grão de milho em relação àqueles alimentados com grão de sorgo. Os cordeiros apresentam consumos relativos superiores aos borregos, porém sua resposta zootécnica é maior. O uso de dietas de alto concentrado de sorgo ou de milho proporcionou resultados semelhantes.
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Gorelick, Robert J., William Fu, Tracy D. Gagliardi, William J. Bosche, Alan Rein, Louis E. Henderson, and Larry O. Arthur. "Characterization of the Block in Replication of Nucleocapsid Protein Zinc Finger Mutants from Moloney Murine Leukemia Virus." Journal of Virology 73, no. 10 (October 1, 1999): 8185–95. http://dx.doi.org/10.1128/jvi.73.10.8185-8195.1999.
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ABSTRACT Mutagenesis studies have shown that retroviral nucleocapsid (NC) protein Zn2+ fingers (-Cys-X2-Cys-X4-His-X4-Cys- [CCHC]) perform multiple functions in the virus life cycle. Moloney murine leukemia virus mutants His 34→Cys (CCCC) and Cys 39→His (CCHH) were able to package their genomes normally but were replication defective. Thermal dissociation experiments showed that the CCHH mutant was not defective in genomic RNA dimer structure. Primer tRNA placement on the viral genome and the ability of the tRNA to function in reverse transcription initiation in vitro also appear normal. Some “full-length” DNA copies of the viral genome were synthesized in mutant virus-infected cells. The CCCC and CCHH mutants produced these DNA copies at greatly reduced levels. Circle junction fragments, amplified from two-long-terminal-repeat viral DNA (vDNA) by PCR, were cloned and characterized. Remarkably, it was discovered that vDNA isolated from cells infected with mutant virions had a wide variety of abnormalities at the site at which the two ends of the linear precursor had been ligated to form the circle (i.e., the junction between the 5′ end of U3 and the 3′ end of U5). In some molecules, bases were missing from regions corresponding to the U3 and U5 linear vDNA termini; in others, the viral sequences extended either beyond the U5 sequences into the primer-binding site and 5′ leader or beyond the U3 sequences into the polypurine tract into the env coding region. Still other molecules contained nonviral sequences between the linear vDNA termini. Such defective genomes would certainly be unsuitable substrates for integration. Thus, strict conservation of the CCHC structure in NC is required for infection events prior to and possibly including integration.
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Phonera, Marvin Collen, Martin Chitolongo Simuunza, Henson Kainga, Joseph Ndebe, Mwelwa Chembensofu, Elisha Chatanga, Setiala Kanyanda, et al. "Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever in Cattle of Smallholder Farmers in Central Malawi." Pathogens 10, no. 12 (December 10, 2021): 1613. http://dx.doi.org/10.3390/pathogens10121613.
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Crimean-Congo hemorrhagic fever virus (CCHFV) is endemic in Africa, Asia, and Eastern Europe where it circulates among animals and ticks causing sporadic outbreaks in humans. Although CCHF is endemic in sub-Saharan Africa, epidemiological information is lacking in many countries, including Malawi. To assess the risk of CCHF in Malawi, we conducted an epidemiological study in cattle reared by smallholder livestock farmers in central Malawi. A cross-sectional study was conducted in April 2020 involving seven districts, four from Kasungu and three from Lilongwe Agriculture Development Divisions. A structured questionnaire was administered to farmers to obtain demographic, animal management, and ecological risk factors data. Sera were collected from randomly selected cattle and screened for CCHF virus (CCHFV) specific antibodies using a commercial ELISA kit. Ticks were collected from cattle and classified morphologically to species level. An overall CCHFV seropositivity rate of 46.9% (n = 416; 95% CI: 42.0–51.8%) was observed. The seropositivity was significantly associated with the age of cattle (p < 0.001), sex (p < 0.001), presence of ticks in herds (p = 0.01), district (p = 0.025), and type of grazing lands (p = 0.013). Five species of ticks were identified, including Hyalomma truncatum, a known vector of CCHFV. Ticks of the species Hyalomma truncatum were not detected in two districts with the highest seroprevalence for CCHF and vector competency must be further explored in the study area. To our knowledge, this is the first report of serologic evidence of the presence of CCHV among smallholder cattle in central Malawi. This study emphasizes the need for continued monitoring of CCHFV infection among livestock, ticks, and humans for the development of data-based risk mitigation strategies.
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Wang, Sha, Xiao Liu, Hui Qian, Shizhu Zhang, and Ling Lu. "Calcineurin and Calcium Channel CchA Coordinate the Salt Stress Response by Regulating Cytoplasmic Ca2+Homeostasis in Aspergillus nidulans." Applied and Environmental Microbiology 82, no. 11 (April 1, 2016): 3420–30. http://dx.doi.org/10.1128/aem.00330-16.
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ABSTRACTThe eukaryotic calcium/calmodulin-dependent protein phosphatase calcineurin is crucial for the environmental adaption of fungi. However, the mechanism of coordinate regulation of the response to salt stress by calcineurin and the high-affinity calcium channel CchA in fungi is not well understood. Here we show that the deletion ofcchAsuppresses the hyphal growth defects caused by the loss of calcineurin under salt stress inAspergillus nidulans. Additionally, the hypersensitivity of the ΔcnaAstrain to extracellular calcium and cell-wall-damaging agents can be suppressed bycchAdeletion. Using the calcium-sensitive photoprotein aequorin to monitor the cytoplasmic Ca2+concentration ([Ca2+]c) in living cells, we found that calcineurin negatively regulates CchA on calcium uptake in response to external calcium in normally cultured cells. However, in salt-stress-pretreated cells, loss of eithercnaAorcchAsignificantly decreased the [Ca2+]c, but a deficiency in bothcnaAandcchAswitches the [Ca2+]cto the reference strain level, indicating that calcineurin and CchA synergistically coordinate calcium influx under salt stress. Moreover, real-time PCR results showed that the dysfunction ofcchAin the ΔcnaAstrain dramatically restored the expression ofenaA(a major determinant for sodium detoxification), which was abolished in the ΔcnaAstrain under salt stress. These results suggest that double deficiencies ofcnaAandcchAcould bypass the requirement of calcineurin to induceenaAexpression under salt stress. Finally, YvcA, a member of the transient receptor potential channel (TRPC) protein family of vacuolar Ca2+channels, was proven to compensate for calcineurin-CchA in fungal salt stress adaption.IMPORTANCEThe feedback inhibition relationship between calcineurin and the calcium channel Cch1/Mid1 has been well recognized from yeast. Interestingly, our previous study (S. Wang et al., PLoS One7:e46564, 2012,http://dx.doi.org/10.1371/journal.pone.0046564) showed that the deletion ofcchAcould suppress the hyphal growth defects caused by the loss of calcineurin under salt stress inAspergillus nidulans. In this study, our findings suggest that fungi are able to develop a unique mechanism for adapting to environmental salt stress. Compared to cells cultured normally, the NaCl-pretreated cells had a remarkable increase in transient [Ca2+]c. Furthermore, we show that calcineurin and CchA are required to modulate cellular calcium levels and synergistically coordinate calcium influx under salt stress. Finally, YvcA, a member of of the TRPC family of vacuolar Ca2+channels, was proven to compensate for calcineurin-CchA in fungal salt stress adaption. The findings in this study provide insights into the complex regulatory links between calcineurin and CchA to maintain cytoplasmic Ca2+homeostasis in response to different environments.
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González-del Moral, Octavio, Avelino Martín, Miguel Mena, María del Carmen Morales-Varela, and Cristina Santamaría. "Hydrocarbon species µ3-CCH2–, µ3-CCH3 and µ-CHCH3 supported on Ti3O3." Chemical Communications, no. 29 (2005): 3682. http://dx.doi.org/10.1039/b504467g.
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Maïna, Alima, Abdoulkarim Issa Ibrahim, Abdou Alassane, and Hassane Adakal. "Epidémiologie de la fièvre Hémorragique de Crimée-Congo (FHCC) chez les bovins dans le département de Boboye au Niger." International Journal of Biological and Chemical Sciences 14, no. 3 (June 18, 2020): 698–705. http://dx.doi.org/10.4314/ijbcs.v14i3.5.
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La distribution et la dynamique des populations des tiques est un élément clé dans la connaissance des maladies transmises par ces vecteurs. C’est ainsi que cette étude a été conduite afin de mieux connaître l’épidémiologie de la Fièvre Hémorragique de Crimée-Congo (FHCC) dans les 8 communes du département de Boboye au Niger, où 355 sérums de bovins ont été collectés. En plus des sérums, des tiques ont été collectées sur 144 bovins, soit 18 par commune. Les sérums ont été soumis à un test ELISA (Enzyme Linked Immunosorbent Assay) indirect pour la détection d’anticorps anti-FHCC. Soixante-douze (72) éleveurs ont été interviewés sur leur connaissance de l’écologie des tiques, vecteurs du virus de la FHCC. Les résultats de l’enquête ont révélé que les éleveurs n’ont pas recours aux acaricides et que, dans leur majorité (55/72 soit 76,4 %), ils pratiquent la transhumance. L’étude a permis l’identification de 1342 tiques réparties en trois genres : Hyalomma (91,7%), Amblyomma (5,7%) et Rhipicephalus (Boophilus) (2,6%). La séroprévalence globale a été de 9,1±0,03%. Les communes de Harikanassou et Kiota ont été celles où les fortes prévalences ont été observées de 26,7 ± 12,9% et 22,5 ±12,9%. Le virus de la FHCC est en circulation chez la population animale, alors des investigations doivent être faites chez la population humaine.Mots clés : Anticorps anti-FHCC, Enzyme Linked Immunosorbent Assay Indirecte, Prévalence, Sérums, Tiques.
English Title: Crimean-Congo Hemorrhagic Fever (CCHF) ’s Epidemiology in cattle in Boboye’s department of Niger Republic
To understand disease transmission by ticks, knowledge of population dynamics and distribution of these vectors are essentials. To sought that, the epidemiology of Crimean-Congo Hemorrhagic Fever (CCHF) in Niger Republic was studied by sampling 355 bovines (sera and ticks) in eight (8) local governments in Boboye’s department. Eighteen (18) bovines were sampled for ticks collection per local government making them a total of 144 bovine. Indirect ELISA test (enzyme-linked immunosorbent assay) was used to detect anti- CCHF antibodies. Seventy-two (72) farmers were surveyed on their knowledge on ticks’ ecology, main vectors of CCHF virus. The results revealed that farmers are not using acaricides, and their majority (55/72 thus 76.4%) practice Transhumance. The study allowed the identification of 1342 ticks distributed in 3 genus: Hyalomma (91.7%), Amblyomma (5.7%) and Rhipicephalus (Boophilus) (2.6%). The global seroprevalence against CCHF was (9.1 ± 0.03) %. Harikanassou and Kiota were the most affected local governments with respectively (26.7±12.9) % and (22.5±12,9) % prevalence. CCHV virus is circulating in animal population, so investigations must be made in human population.
Keywords: Anti-CCHF antibodies, Indirect Enzyme Linked Immunosorbent Assay, Prevalence, Sera, Ticks.
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Zidi, Sid Ahmed, Mohamed Khatir, and Samir Hadjeri. "Steady - State and Transient Performance of HVDC Link Based 3-Level vsc Supplying a Passive Load = Performances en Régime Stationnaire et Transitoire de la Liaison CCHT Utilisant le VSC 3 Niveaux Alimentant une Charge Passive." Synthèse : Revue des Sciences et de la Technologie, no. 31 (2015): 80–89. http://dx.doi.org/10.12816/0027859.
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Chen, Chien-Juan, Ting-Yi Lin, Chao-Ling Wang, Chi-Kung Ho, Hung-Yi Chuang, and Hsin-Su Yu. "Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator Transport HFE Polymorphism on the Human Red Blood Cell Mean Corpuscular Volume (MCV)." International Journal of Environmental Research and Public Health 16, no. 3 (January 27, 2019): 354. http://dx.doi.org/10.3390/ijerph16030354.
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Research has shown that long-term exposure to lead harms the hematological system. The homeostatic iron regulator HFE (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals. The aim of our study was to investigate whether the HFE genotype modifies the blood lead levels that affect the distributions of serum iron and other red blood cell indices. Overall, 121 lead workers and 117 unexposed age-matched subjects were recruited for the study. The collected data included the blood lead levels, complete blood count, serum iron, total iron binding capacity, transferrin, and ferritin, which were measured during regular physical examinations. All subjects filled out questionnaires that included demographic information, medical history, and alcohol and tobacco consumption. HFE genotyping for C282Y and H63D was determined using polymerase chain reaction and restriction fragment length polymorphism (PCR/RFLP). The mean blood lead level in lead workers was 19.75 µg/dL and was 2.86 µg/dL in unexposed subjects. Of 238 subjects, 221 (92.9%) subjects were wild-type (CCHH) for HFE C282Y and H63D, and 17 (7.1%) subjects were heterozygous for a H63D mutation (CCHD). Multiple linear regression analysis showed that blood lead was significantly negatively associated with hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular volume (MCV), whereas the HFE variant was associated negatively with MCV and positively with ferritin. An interactive influence on MCV was identified between blood lead and HFE variants. Our research found a significant modifying effect of the HFE variant, which possibly affected MCV. The HFE H63D heterozygous (CCHD) variant seemed to provide a protective factor against lead toxicity. Future studies should focus on competing binding proteins between iron and lead influenced by gene variation.
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Bertone, M., D. L. J. Vucković, A. Cunje, C. F. Rodriquez, E. Lee-Ruff, and A. C. Hopkinson. "The thioformamidyl group as an α-substituent in carbocations." Canadian Journal of Chemistry 73, no. 9 (September 1, 1995): 1468–77. http://dx.doi.org/10.1139/v95-182.
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Abinitio: molecular orbital calculations at MP2(FULL)/6-311G(d,p) or MP2(FULL)/6-31G(d,p) are reported for carbocations RR′CCHO+, RR′CCHS+, RR′CCONH2+, and RR′CCSNH2+where R and R′ are H, CH3, C-C3H5, and C6H5. Primary (R=R′=H), secondary (R=H, R′=alkyl or phenyl), and tertiary (R′=R′=CH3) ions prefer the cyclic oxiranyl or thiiranyl structure 9, with the open structure 8 being a transition structure for ring opening. Tertiary carbocations with R=R′=phenyl or cyclopropyl and the 9-thioformamidyl-9-fluorenyl cation have the open structure. Isodesmic reactions show CONH2 to be weakly stabilizing in the methyl cation, and CSNH2 has a larger stabilizing effect, roughly equivalent to that of a methyl group. An α-thioamide substituent is less stabilizing in the ethyl cation and even less stabilizing in the isopropyl cation. In C6H5CHCSNH2+ the CSNH2 group is slightly destabilizing and, by extrapolation, is more destabilizing in Ar2CCSNH2+. The rearrangement of the α-thioformamidyl-benzyl cation to benzothiophene is calculated to have a low barrier, 15.4 kcal/mol at HF/6-31G(d,p). Keywords: molecular orbitals, destabilized carbocations, rearrangement.
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Mitchell, Nicky, and P. Kenneth Gordon. "Attitudes Towards Computerized CBT for Depression Amongst a Student Population." Behavioural and Cognitive Psychotherapy 35, no. 4 (May 14, 2007): 421–30. http://dx.doi.org/10.1017/s1352465807003700.
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Some studies of computerized cognitive behaviour therapy (CCBT) have found evidence of its effectiveness, yet a number have reported low uptake and/or completion rates. This study investigated attitudes towards CCBT for depression amongst 122 university students. The credibility of CCBT, expectancy-for-improvement and perceived likelihood of using it were all poor, although a minority (9.8%) stated a preference for CCBT over other interventions. When 20 of the original sample received a demonstration of a CCBT programme for depression, significant increases in credibility, expectancy-for-improvement and in perceived likelihood of using CCBT were found. Numbers stating a preference for CCBT increased to 30%. At both stages, most students stated a preference for CCBT to be accompanied by counselling. Qualitative analysis provided information about factors that might influence these attitudes. Implications for service delivery are discussed.
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Rossi, Robert M., Allison Divanovic, and Emily A. DeFranco. "Obstetric Outcomes Associated with Fetal Cyanotic Congenital Heart Disease." American Journal of Perinatology 36, no. 07 (October 29, 2018): 701–8. http://dx.doi.org/10.1055/s-0038-1673652.
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Objective To characterize obstetric outcomes associated with cyanotic congenital heart disease (CCHD) in a contemporary population. Study Design We conducted a population-based retrospective cohort study of all livebirths in Ohio (2006–2015). Obstetric characteristics of pregnancies complicated by fetal CCHD were compared with those without CCHD, excluding those with other anomalies and aneuploidy. The primary objective was to determine the risk of cesarean delivery among CCHD affected pregnancies. Multivariate logistic regression estimated the influence of CCHD on these obstetric outcomes. Results Among 1,463,506 live births in Ohio, there were 863 (0.06%) CCHD affected births. The overall cesarean rate was 45.9 versus 31.0% (p< 0.001) in CCHD compared with non-CCHD pregnancies. After adjusting for various confounders, CCHD affected pregnancies were associated with a higher risk for cesarean delivery (adjusted relative risk [aRR]: 2.0, 95% confidence interval [CI]: 1.6–2.4), preterm birth (PTB) (aRR: 1.5, 95% CI: 1.1–2.0), induction of labor (aRR: 1.2, 95% CI: 1.04–1.4), small for gestational age (SGA) birthweight (aRR: 2.4, 95% CI: 2.0–2.9), and fetal intolerance of labor (FIOL; aRR: 2.0, 95% CI: 1.6–2.4). Women with CCHD affected pregnancies were also less likely to undergo a trial of labor (aRR: 0.4, 95% CI: 0.3–0.5) prior to cesarean delivery. Conclusion Obstetric outcomes associated with CCHD include higher risk for cesarean delivery, PTB, SGA, and FIOL.
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Ramboarina, S., S. Druillennec, N. Morellet, S. Bouaziz, and B. P. Roques. "Target Specificity of Human Immunodeficiency Virus Type 1 NCp7 Requires an Intact Conformation of Its CCHC N-Terminal Zinc Finger." Journal of Virology 78, no. 12 (June 15, 2004): 6682–87. http://dx.doi.org/10.1128/jvi.78.12.6682-6687.2004.
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ABSTRACT The modification of zinc-binding residues inside the conserved CCHC motif of human immunodeficiency virus type 1 NCp7, in particular into CCHH, induces a complete loss of infectivity. Since the mutant His28NCp7 has been shown to be devoid of infectivity in vivo, the structure-function relationships of the mutant His28(12-53)NCp7 were investigated by nuclear magnetic resonance and surface plasmonic resonance. Although the Cys28→His mutation modifies drastically the structure of the core domain (residues 12 to 53) of NCp7, His28(12-53)NCp7 still interacts with a 10-fold-lower affinity to specific nucleic acid targets, such as SL3, a stem-loop critically involved in viral RNA packaging, and without affinity change with the nonspecific, single-stranded nucleic acid poly(T). Moreover, His28(12-53)NCp7 and native (12-53)NCp7 displayed the same affinity with reverse transcriptase, but the natures of the complexes are probably different, accounting for the drastic reduction in the amount of RNA packaged in the mutated virus. We propose a structural model of His28(12-53)NCp7 that provides insights into the NCp7 structural features necessary for target recognition and that shows that the specific native structure of the zinc finger domain is strictly required for the optimal target selectivity of NCp7.
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Wei, Peixing, Brad Jianhe Wang, Hao Li, Libin Wang, Yingchun Gong, and Suyong Huang. "Performance evaluation of a novel cross-laminated timber made from flattened bamboo and wood lumber." BioResources 16, no. 3 (June 1, 2021): 5187–202. http://dx.doi.org/10.15376/biores.16.3.5187-5202.
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A novel flattened bamboo-wood composite cross-laminated timber (CCLT) made from flattened bamboo and hemlock lumber was developed, and its mechanical performance was investigated and quantified in this work. The results demonstrated that the CCLT columns and control hemlock CLT counterparts had nearly equal axial compression strength, but the CCLT yielded a higher compression modulus of elasticity (MOE). Additionally, the CCLT compression behaviors were not significantly affected by the height. Compared with hemlock CLT, the CCLT exhibited a slightly higher flatwise bending MOE and strength in the major strength direction. Furthermore, the MOE and strength of the CCLT under edgewise bending were 17.3% less and 16.2% greater than those under flatwise bending, respectively. The load-carrying capacity of the CCLT was mainly governed by the interfacial failure between the bamboo and wood, in which no rolling shear failure was observed. Those features are unique for the new CCLT for engineered applications.
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Gerhards, S. A. H., L. E. de Graaf, L. E. Jacobs, J. L. Severens, M. J. H. Huibers, A. Arntz, H. Riper, G. Widdershoven, J. F. M. Metsemakers, and S. M. A. A. Evers. "Economic evaluation of online computerised cognitive–behavioural therapy without support for depression in primary care: randomised trial." British Journal of Psychiatry 196, no. 4 (April 2010): 310–18. http://dx.doi.org/10.1192/bjp.bp.109.065748.
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BackgroundEvidence about the cost-effectiveness and cost utility of computerised cognitive–behavioural therapy (CCBT) is still limited. Recently, we compared the clinical effectiveness of unsupported, online CCBT with treatment as usual (TAU) and a combination of CCBT and TAU (CCBT plus TAU) for depression. The study is registered at the Netherlands Trial Register, part of the Dutch Cochrane Centre (ISRCTN47481236).AimsTo assess the cost-effectiveness of CCBT compared with TAU and CCBT plus TAU.MethodCosts, depression severity and quality of life were measured for 12 months. Cost-effectiveness and cost-utility analyses were performed from a societal perspective. Uncertainty was dealt with by bootstrap replications and sensitivity analyses.ResultsCosts were lowest for the CCBT group. There are no significant group differences in effectiveness or quality of life. Cost-utility and cost-effectiveness analyses tend to be in favour of CCBT.ConclusionsOn balance, CCBT constitutes the most efficient treatment strategy, although all treatments showed low adherence rates and modest improvements in depression and quality of life.
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Temur, Ahmet Irfan, Jens H. Kuhn, David B. Pecor, Dmitry A. Apanaskevich, and Maryam Keshtkar-Jahromi. "Epidemiology of Crimean-Congo Hemorrhagic Fever (CCHF) in Africa—Underestimated for Decades." American Journal of Tropical Medicine and Hygiene 104, no. 6 (June 2, 2021): 1978–90. http://dx.doi.org/10.4269/ajtmh.20-1413.
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Abstract.Crimean-Congo hemorrhagic fever (CCHF) is endemic in Africa, but the epidemiology remains to be defined. Using a broad database search, we reviewed the literature to better define CCHF evidence in Africa. We used a One Health approach to define the impact of CCHF by reviewing case reports, human and animal serology, and records of CCHF virus (CCHFV) isolations (1956–mid-2020). In addition, published and unpublished collection data were used to estimate the geographic distribution of Hyalomma ticks and infection vectors. We implemented a previously proposed classification scheme for organizing countries into five categories by the level of evidence. From January 1, 1956 to July 25, 2020, 494 CCHF cases (115 lethal) were reported in Africa. Since 2000, nine countries (Kenya, Mali, Mozambique, Nigeria, Senegal, Sierra Leone, South Sudan, Sudan, and Tunisia) have reported their first CCHF cases. Nineteen countries reported CCHF cases and were assigned level 1 or level 2 based on maturity of their surveillance system. Thirty countries with evidence of CCHFV circulation in the absence of CCHF cases were assigned level 3 or level 4. Twelve countries for which no data were available were assigned level 5. The goal of this review is to inform international organizations, local governments, and healthcare professionals about shortcomings in CCHF surveillance in Africa to assist in a movement toward strengthening policy to improve CCHF surveillance.
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Liu, Min, and Angie Gelli. "Elongation Factor 3, EF3, Associates with the Calcium Channel Cch1 and Targets Cch1 to the Plasma Membrane in Cryptococcus neoformans." Eukaryotic Cell 7, no. 7 (May 23, 2008): 1118–26. http://dx.doi.org/10.1128/ec.00116-08.
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ABSTRACT Ca2+-mediated signaling events in eukaryotic cells are initiated by Ca2+ channels located in the plasma membranes and endomembranes. Cch1, a high-affinity Ca2+ channel in the plasma membranes of Cryptococcus neoformans and other fungi, plays a role in many different cellular processes, but the mechanisms that regulate Cch1 are not well understood. A Ras recruitment two-hybrid screen was used to identify protein partners of Cch1 as a means of identifying possible mechanisms of channel regulation. Here, we show that Cch1 specifically associates with a cytoplasmic protein known as elongation factor 3 (EF3). The robust interaction between the cytosolic C terminus of the Cch1 protein and EF3 shown here was confirmed by demonstrating that Cch1 could coimmunoprecipitate with EF3 in yeast lysates. To examine the effects of EF3 on Cch1 behavior, we altered the EF3 gene function by constructing a C. neoformans antisense EF3 repression strain. Our results show that the repression of EF3 led to the mislocalization of Cch1, suggesting a role for EF3 in targeting Cch1 to the plasma membrane of C. neoformans. Consistent with this notion, the antisense EF3 repression strain displayed a growth defect under conditions of limited extracellular Ca2+. Collectively, these results suggest that EF3 and Cch1 are functionally coupled and that EF3 has a function apart from its role in the protein translation cycle.
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Kaltenthaler, Eva, Glenys Parry, and Catherine Beverley. "COMPUTERIZED COGNITIVE BEHAVIOUR THERAPY: A SYSTEMATIC REVIEW." Behavioural and Cognitive Psychotherapy 32, no. 1 (January 2004): 31–55. http://dx.doi.org/10.1017/s135246580400102x.
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Depression, anxiety disorders and phobias are common mental health problems associated with considerable occupational and interpersonal impairment. Although there is substantial evidence to support the use of cognitive behaviour therapy (CBT) in the treatment of these disorders, access is limited. Computerized cognitive behaviour therapy (CCBT) is one of a variety of aids to self-management that offer patients the potential benefits of CBT with less therapist involvement than therapist led CBT (TCBT). In this systematic review of the efficacy of CCBT, 16 studies were identified. Of these 11 were RCTS and the remaining 5 were pilot or cohort studies. The quality of studies ranged from poor to moderate (although the criteria used precluded the highest rating). In the studies comparing CCBT with TCBT, five studies showed CCBT have equivalent outcomes to TCBT. One study of depressed inpatients found TCBT to be significantly more effective than CCBT. Four studies found CCBT to be more effective than treatment as usual (TAU). Two studies found CCBT to be no more effective than TAU. Two studies compared CCBT with bibliotherapy. Of these, one study found CCBT to be as effective as bibliotherapy and one found bibliotherapy to be significantly more effective than CCBT on some outcome measures. Although the results of this review are not conclusive, CCBT is potentially useful in the treatment of anxiety disorders, depression and phobias. From the results of this review, we make three recommendations to improve the quality of research in this field, and suggest four areas requiring further research.
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Fleming, Theresa, and Sally Merry. "Youth Work Service Providers' Attitudes Towards Computerized CBT for Adolescents." Behavioural and Cognitive Psychotherapy 41, no. 3 (May 17, 2012): 265–79. http://dx.doi.org/10.1017/s1352465812000306.
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Background:Attitudes of social service providers towards computerized CBT (cCBT) might affect use of cCBT by their clients and may provide important insights that should be considered in dissemination. There is no literature exploring the attitudes of providers of youth work services towards cCBT despite the likelihood of them having close relationships with young people at high risk of mental ill-health.Method:Focus groups and semi-structured interviews were undertaken with a total of 40 providers (21 youth workers and social service staff providing alternative schooling, justice or other intensive youth work programmes to adolescents, 6 youth service managers, 2 trainers, 5 peer leaders and 6 trainees).Results:Participants considered supporting young people who were distressed to be an important part of their role. They were generally interested in cCBT, especially those who were more mental health oriented and those who saw a cCBT programme in action. Their greatest concerns regarding cCBT related to it possibly displacing human contact, while advantages were seen as its appeal to young people and its potential therapeutic power. They would utilize cCBT in a range of ways, with many wishing to offer it in group settings. Training and resources would be required for them to use cCBT.Conclusions:Many providers of youth work services would like to be involved in the use of cCBT; this might extend the reach of cCBT to vulnerable young people. They would wish to utilize cCBT in ways that fit their current approaches. Providers’ opinions need to be considered in the dissemination of cCBT.
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Cagatay, Atahan, Mahir Kapmaz, Asli Karadeniz, Seniha Basaran, Mustafa Yenerel, Selim Yavuz, Kenan Midilli, Halit Ozsut, Haluk Eraksoy, and Semra Calangu. "Haemophagocytosis in a patient with Crimean–Congo haemorrhagic fever." Journal of Medical Microbiology 56, no. 8 (August 1, 2007): 1126–28. http://dx.doi.org/10.1099/jmm.0.46910-0.
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Crimean–Congo haemorrhagic fever (CCHF) is a severe disease with a case fatality of 2.8 to 80 %. A patient dwelling in an endemic region for CCHF was admitted with fever preceding bleeding diathesis and pancytopenia. Despite no history of tick exposure, CCHF was highly suspected. With an oral ribavirin therapy, clinical and laboratory improvements were obtained. The diagnosis was confirmed by detection of IgM antibody to CCHF virus and positive RT-PCR. Although the main pathogenesis of CCHF infection is not elucidated yet, haemophagocytosis, a symptom rarely reported in viral haemorrhagic fevers, was observed in this case. Haemophagocytosis is suggested to have a role in the development of pancytopenia in CCHF, the mechanism of which still needs to be investigated, probably with cytokine studies. Together with clinical symptoms and patient history, haemophagocytosis may be an indicator for CCHF.
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Bestetti, Reinaldo B., Renata Dellalibera-Joviliano, Ellen Rizzi, Giselle F. Bonacio, Milton Faria-Jr, Rosemeire Furlan-Daniel, and Suzeley Castro-França. "Plasma Levels of Matrix Metalloproteinases 2 and 9 in Patients with Chronic Chagas Heart Disease and Systemic Arterial Hypertension: Correlation with TGF-Beta Plasma Levels." Cardiology Research and Practice 2023 (April 19, 2023): 1–7. http://dx.doi.org/10.1155/2023/8484697.
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Background. Chronic Chagas heart disease (CCHD) and systemic arterial hypertension (SAH) frequently coexists in areas where Chagas disease is endemic. The effects of the association of both conditions (CCHD-SAH) on the extracellular matrix (ECM) remodeling are unknown. Matrix metalloproteinases (MMP) 2 and 9 are involved in ECM remodeling. The aim of this study was to evaluate MMP 2 and MMP9 in CCHD-SAH patients and to correlate their levels with those of the profibrogenic cytokine TGF-beta. Methods. We included 19 patients with CCHD-SAH, 14 patients with CCHD alone, and 19 controls matched by sex and age. MMP-2 and MMP-9 plasma levels were studied by gel zymography and showed as optical densities (OD). TGF-beta plasma levels were measured by double-ligand ELISA and expressed as pg/mL. Results. Median (5th, 95th) MMP-2 plasma levels were 1224.7 OD (1160, 1433.5) in patients with CCHD alone, 1424.1 OD (1267.5, 1561) in patients with CCHD-SAH, and 940 OD (898.1, 1000.8) in controls ( p = 0.001 ). MMP-9 plasma levels were 1870 OD (1740, 1904.1) in patients with CCHD alone, 1754.6 OD (1650, 2049) in those with CCHD-SAH and 89.7 OD (80, 96) in controls ( p = 0.0003 ). MMP-9 plasma levels were higher than those of MMP 2 in patients with CCHD-SAH ( p = 0.01 ). No correlation was found between TGF-beta plasma levels with MMP-2 serum levels (r = 0.12; p = 0.7 ), but a moderate negative correlation (r = −0.46; p = 0.048 ) was observed between TGF-beta and MMP-9 plasma levels. Conclusions. MMP-2 and especially MMP-9 may play a role in the ECM remodeling process in patients with CCHD-SAH. TGF-Beta may counteract the MMP effect on the ECM remodeling process in patients with CCHD-SAH.
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Putu Dianisa Rosari Dewi, Eka Gunawijaya, and Ni Putu Veny Kartika Yantie. "Early versus late diagnosis of critical congenital heart disease at Sanglah Hospital Denpasar, Bali." GSC Advanced Research and Reviews 11, no. 3 (June 30, 2022): 072–76. http://dx.doi.org/10.30574/gscarr.2022.11.3.0159.
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Background: Critical congenital heart disease (CCHD) remains significant clinical and public health challenge. Risk of morbidity and mortality in CCHD increases when there is a delay in diagnosis and referral to a tertiary center with expertise in treating these patients. In the last few years, pulse oximetry screening for CCHD in newborns has been added to the list of recommended uniform screening panels and advocated by several health-care authorities. Early detection of CCHD by using pulse oxymetry was recommended by American Academy of Pediatrics (AAP), the American Heart Association, and the American College of Cardiology to improve early identification of infants with CCHD. Objective: To describe early versus late diagnosis of critical congenital heart disease (CCHD) at single tertiary center. Methods: A retrospective observational study was conducted in Sanglah Hospital, Bali. Data collected from medical records. Early diagnosis defined as diagnosis which made during prenatal examination or before birth hospital dischare. Late diagnosis defined as diagnosis which made after birth hospital discharge, after 3 days of birth, or even at death. Diagnosis of CCHD was retrieved based on echocardiography examination. Results: From June 2016 to February2020 we found 86 CCHD cases which were tetralogy of Fallot (41 cases), pulmonary atresia (15 cases), transposition of great arteries (14 cases), total anomalous pulmonary venous return (4 cases), tricuspid atresia (3 cases), truncus arteriosus (3 cases), and hypoplastic left heart syndrome (1 case). Only 26% cases of children with CCHD were diagnosed early, mostly came with chief complaint bluish appearance. Range of oxygen saturation at diagnosis varied from 51-90%. Among cases with late diagnosis, the most common defect was tetralogy of Fallot. Most late diagnosed CCHD came because of referral from other hospitals or pediatricians. Conclusion: The rate of delayed CCHD diagnosis still occurs in 74%. Factors that might be contribute to late CCHD diagnosis include certain CCHD types, nontertiary hospital nursery and absence of clinical findings.
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FAROQUE, MD ABDULLAH AL, MARUF HOSSAIN MINAR, NUR UN NESA, MD RAFIQUL ISLAM SARDER, and MD FAZLUL AWAL MOLLAH. "Genetic characterisation of wild catla (Catla catla Hamilton) populations using microsatellite DNA markers." Bangladesh Journal of Fisheries 33, no. 2 (December 31, 2021): 167–76. http://dx.doi.org/10.52168/bjf.2021.33.19.
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The genetic characterisation of catla, Catla catla populations from three rivers, the Halda, the Jamuna, and the Padma was performed employing six microsatellite DNA markers Ccat A12, Ccat C3, Ccat C6, Ccat C8, Ccat G1, and Ccat G2. All the studied loci were detected as polymorphic (P95) in nature. The appearance of five rare alleles in Halda, at Ccat A12 (149 and 153 bp), Ccat C6 (180 bp), and Ccat C8 (98 and 104 bp) demonstrated the genetic richness of the Halda population. The average highest (6.33) and lowest (4.67) number of alleles were recorded in the Halda and the Padma populations, respectively. The Halda population exhibited the highest (0.5111) average heterozygosity (Ho) compared to the Jamuna (0.4889) and the Padma (0.4167). The population differentiation (FST) between the Halda and the Padma populations was the highest (0.0653) and the lowest (0.0366) between the Halda and the Jamuna populations. The highest gene flow (Nm) (6.5747) existed between the Halda, and the Jamuna populations and the lowest (3.5811) between the Halda and the Padma populations. These findings revealed a reduced genetic variability of wild stocks of C. catla in relation to allelic diversity and heterozygosity that provided a benchmark for future comprehensive management programme to conserve the genetic resources of wild populations of this species.
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Stallard, Paul, Thomas Richardson, and Sophie Velleman. "Clinicians' Attitudes Towards the Use of Computerized Cognitive Behaviour Therapy (cCBT) with Children and Adolescents." Behavioural and Cognitive Psychotherapy 38, no. 5 (July 9, 2010): 545–60. http://dx.doi.org/10.1017/s1352465810000421.
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Background: Research has begun to examine the effectiveness of computerized cognitive behaviour therapy (cCBT) with children and adolescents. Although cCBT appears promising, the attitudes of clinicians towards this type of intervention with children and young people have not been assessed, yet these are important in determining when and if cCBT will be offered. Aims: To survey clinicians’ attitudes towards cCBT with children and adolescents. Method: A self-report questionnaire was completed by 43 mental health professionals attending a conference. Results: Clinicians were cautious but generally positive about the use of cCBT with children and adolescents, particularly for the delivery of prevention programmes and in the treatment of mild/moderate problems. Few felt that cCBT should be available freely online without any professional support. Indeed, the lack of a therapeutic relationship and professional support were identified as the biggest problems, whilst the potential to use cCBT at home was the greatest advantage identified. Conclusions: This survey suggests that clinicians are generally positive about the use of cCBT with children and adolescents for the prevention and treatment of mild/moderate problems. Further research is required to address clinicians’ concerns about the effectiveness of cCBT for more substantial problems and the level of therapeutic support required.
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Jo, Haesung, Jaemin Park, and Insu Kim. "Environmentally Constrained Optimal Dispatch Method for Combined Cooling, Heating, and Power Systems Using Two-Stage Optimization." Energies 14, no. 14 (July 8, 2021): 4135. http://dx.doi.org/10.3390/en14144135.
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The reliance on coal-fired power generation has gradually reduced with the growing interest in the environment and safety, and the environmental effects of power generation are now being considered. However, it can be difficult to provide stable power to end-users while minimizing environmental pollution by replacing coal-fired systems with combined cooling, heat, and power (CCHP) systems that use natural gas, because CCHP systems have various power output vulnerabilities. Therefore, purchasing power from external electric grids is essential in areas where CCHP systems are built; hence, optimal CCHP controls should also consider energy purchased from external grids. This study proposes a two-stage algorithm to optimally control CCHP systems. In Stage One, the optimal energy mix using the Lagrange multiplier method for state-wide grids from which CCHP systems purchase deficient electricity was calculated. In Stage Two, the purchased volumes from these grids were used as inputs to the proposed optimization algorithm to optimize CCHP systems suitable for metropolitan areas. We used case studies to identify the accurate energy efficiency, costs, and minimal emissions. We chose the Atlanta area to analyze the CCHP system’s impact on energy efficiency, cost variation, and emission savings. Then, we calculated an energy mix suitable for the region for each simulation period. The case study results confirm that deploying an optimized CCHP system can reduce purchased volumes from the grid while reducing total emissions. We also analyzed the impact of the CCHP system on emissions and cost savings.
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Vasilenko, N. F., E. A. Manin, O. V. Maletskaya, A. S. Volynkina, D. A. Prislegina, O. V. Semenko, and A. N. Kulichenko. "The modern condition of Crimean-Congo hаemorrhagic fever natural focus in the Russian Federation." Journal of microbiology epidemiology immunobiology, no. 4 (September 2, 2019): 46–52. http://dx.doi.org/10.36233/0372-9311-2019-4-46-52.
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Aim.To determine the boundaries of the Crimean-Congo haemorrhagic fever (CCHF) natural focus in the Russian Federation at the current stage, to clarify the range of the main reservoirs and vectors of CCHF pathogen, to assess the epidemiological capacity of the natural focus.Materials and methods.The materials of epidemiological and epizootological monitoring of the CCHF natural focus, methods of epidemiological and epizootological analysis, molecular-genetic and cartographic methods were used in the work. The findings have been treated using by software package Microsoft Office Excel 2010.Results.The unified integrity of the CCHF semi-desert-steppe natural focus, which occupies vast territory of the southern part of the Russian Federation of 831 thousand square kilometres, is science-based. Expanding the geographic area of the CCHF agent with the involvement new administrative district can be seen. The trend of shifting of the CCHF natural focus borders in a northerly direction has been established. An increasing of epidemiological capacity of the CCHF natural focus has been noted.Hyalomma marginatumticks are the main reservoirs and vectors of CCHF virus. The genotype «Europe-1» is predominant genotype in the natural focus.Conclusion.It is necessary to improve the tactics of CCHF epidemiological surveillance using modern science-based approaches. For example, automated forecasting-modeling system, using results of multifactorial risk analysis, which have an impact on the intensity of CCHF epidemic appearances, allows to quantitative forecast epidemiological situation on this infection in the aggregate and for certain subjects of the south of the Russian Federation.
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Tang, Qing, Masayuki Saijo, Yuzhen Zhang, Muer Asiguma, Dong Tianshu, Lei Han, Bawudong Shimayi, Akihiko Maeda, Ichiro Kurane, and Shigeru Morikawa. "A Patient with Crimean-Congo Hemorrhagic Fever Serologically Diagnosed by Recombinant Nucleoprotein-Based Antibody Detection Systems." Clinical Diagnostic Laboratory Immunology 10, no. 3 (May 2003): 489–91. http://dx.doi.org/10.1128/cdli.10.3.489-491.2003.
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ABSTRACT We treated a male patient with Crimean-Congo hemorrhagic fever (CCHF). The diagnosis of CCHF was confirmed by reverse transcription-PCR and recombinant nucleoprotein (rNP)-based immunoglobulin G (IgG) and IgM capture enzyme-linked immunosorbent assays of serially collected serum samples. The patient was treated with intravenous ribavirin and recovered with no consequences. The study indicates that rNP-based CCHF virus antibody detection systems are useful for confirming CCHF virus infections. This case also suggests that intravenous ribavirin therapy may be promising for the treatment of CCHF patients.
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Titov, Nickolai. "Status of Computerized Cognitive Behavioural Therapy for Adults." Australian & New Zealand Journal of Psychiatry 41, no. 2 (February 2007): 95–114. http://dx.doi.org/10.1080/00048670601109873.
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A growing body of evidence supports the efficacy of computerized cognitive behavioural therapy (CCBT). This technology has the potential to increase the capacity of mental health services, and to overcome some of the barriers to accessing mental health services, including stigma, traveling time for rural patients, treatment delays, and the low availability of skilled clinicians. This review discusses key issues around the implementation of CCBT in current mental health services, and summarizes recent evidence for the efficacy of CCBT in anxiety and depression. Many CCBT systems exist, and the evidence for each varies in quality and quantity. It is concluded that CCBT, particularly guided by a therapist, represents a promising resource. However, considerable work needs to be done to develop CCBT techniques that are appropriate to Australasian populations, acceptable to patients and clinicians, easy to use, and are clinically and cost effective. Suggestions are made for further research and useful website addresses are provided to assist clinicians in familiarizing themselves with CCBT.
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Zhang, Liting, Weijun Gao, Yongwen Yang, and Fanyue Qian. "Impacts of Investment Cost, Energy Prices and Carbon Tax on Promoting the Combined Cooling, Heating and Power (CCHP) System of an Amusement Park Resort in Shanghai." Energies 13, no. 16 (August 17, 2020): 4252. http://dx.doi.org/10.3390/en13164252.
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Poor economic performance has limited the diffusion of the combined cooling, heating, and power (CCHP) system. Various factors influence the economic performance of the CCHP system. To analyze the impacts of these different factors and promote the CCHP system, this study evaluated its comprehensive performance through a multi-criteria method, using an amusement park resort in Shanghai as a research case. First, three CCHP systems with different penetration rates were presented and simulated in a transient simulation model for comparison. The economic and environmental performance of these different penetration CCHP systems were evaluated based on the dynamic payback period and carbon dioxide emissions. The impacts of investment cost, energy prices, investment subsidy and a carbon tax on the economic performance of the three systems were discussed, and a sensitivity analysis was used to compare these factors. The results show that the current subsidy can reduce the economic gap between the CCHP system and the conventional system, but it still needs to be increased by 1.71 times to achieve market competitiveness of the CCHP system with 100% penetration under the current investment cost and energy prices. In addition, the introduction of a carbon tax could accelerate the promotion of the CCHP system. When the carbon tax reaches 25 $/ton, the CCHP system becomes the best choice of energy supply system.
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Liu, Min, Ping Du, Garrett Heinrich, Gary M. Cox, and Angie Gelli. "Cch1 Mediates Calcium Entry in Cryptococcus neoformans and Is Essential in Low-Calcium Environments." Eukaryotic Cell 5, no. 10 (September 1, 2006): 1788–96. http://dx.doi.org/10.1128/ec.00158-06.
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ABSTRACT The ability of Cryptococcus neoformans to grow at the mammalian body temperature (37°C to 39°C) is a well-established virulence factor. Growth of C. neoformans at this physiological temperature requires calcineurin, a Ca2+/calmodulin-dependent protein phosphatase. When cytosolic calcium concentrations are low (∼50 to 100 nM), calcineurin is inactive and becomes active only when cytosolic calcium concentrations rise (∼1 to 10 μM) through the activation of calcium channels. In this study we analyzed the function of Cch1 in C. neoformans and found that Cch1 is a Ca2+-permeable channel that mediates calcium entry in C. neoformans. Analysis of the Cch1 protein sequence revealed differences in the voltage sensor (S4 regions), suggesting that Cch1 may have diminished voltage sensitivity or possibly an alternative gating mechanism. The inability of the cch1 mutant to grow under conditions of limited extracellular calcium concentrations ([Ca2+]extracellular, ∼100 nM) suggested that Cch1 was required for calcium uptake in low-calcium environments. These results are consistent with the role of ScCch1 in mediating high-affinity calcium uptake in Saccharomyces cerevisiae. Although the growth defect of the cch1 mutant under conditions of limited [Ca2+]extracellular (∼100 nM) became more severe with increasing temperature (25°C to 38.5°), this temperature sensitivity was not observed when the cch1 mutant was grown on rich medium ([Ca2+]extracellular, ∼0.140 mM). Accordingly, the cch1 mutant strain displayed only attenuated virulence when tested in the mouse inhalation model of cryptococcosis, further suggesting that C. neoformans may have a limited requirement for Cch1 and that this requirement appears to include ion stress tolerance.
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AlHadi, Ahmad N., Khawla A. Alammari, Lojain J. Alsiwat, Nojood E. Alhaidri, Nouf H. Alabdulkarim, Nouf A. Altwaijri, and Shamma A. AlSohaili. "Perception of Mental Health Care Professionals in Saudi Arabia on Computerized Cognitive Behavioral Therapy: Observational Cross-sectional Study." JMIR Formative Research 5, no. 5 (May 3, 2021): e26294. http://dx.doi.org/10.2196/26294.
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Background Mental health disorders are common in Saudi Arabia with a 34% lifetime prevalence. Cognitive behavioral therapy (CBT), a type of psychotherapy, is an evidence-based intervention for the majority of mental disorders. Although the demand for CBT is increasing, unfortunately, there are few therapists available to meet this demand and the therapy is expensive. Computerized cognitive behavioral therapy (cCBT) is a new modality that can help fill this gap. Objective We aimed to measure the knowledge of cCBT among mental health care professionals in Saudi Arabia, and to evaluate their attitudes and preferences toward cCBT. Methods This quantitative observational cross-sectional study used a convenience sample, selecting mental health care professionals working in the tertiary hospitals of Saudi Arabia. The participants received a self-administered electronic questionnaire through data collectors measuring their demographics, knowledge, and attitudes about cCBT, and their beliefs about the efficacy of using computers in therapy. Results Among the 121 participating mental health care professionals, the mean age was 36.55 years and 60.3% were women. Most of the participants expressed uncertainty and demonstrated a lack of knowledge regarding cCBT. However, the majority of participants indicated a positive attitude toward using computers in therapy. Participants agreed with the principles of cCBT, believed in its efficacy, and were generally confident in using computers. Among the notable results, participants having a clinical license and with cCBT experience had more knowledge of cCBT. The overall attitude toward cCBT was not affected by demographic or work-related factors. Conclusions Mental health care professionals in Saudi Arabia need more education and training regarding cCBT; however, their attitude toward its use and their comfort in using computers in general show great promise. Further research is needed to assess the acceptance of cCBT by patients in Saudi Arabia, in addition to clinical trials measuring its effectiveness in the Saudi population.
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ÖNER, Pınar, and Müge ÖZGÜLER. "An evaluation of the laboratory and clinical data of the Crimean-Congo hemorrhagic fever patients during the Covid-19 pandemic." Journal of Experimental and Clinical Medicine 40, no. 1 (March 18, 2023): 107–12. http://dx.doi.org/10.52142/omujecm.40.1.23.
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In this study, the purpose was to investigate the demographic, laboratory, and clinical characteristics of the Crimean-Congo Hemorrhagic Fever (CCHF) cases that were treated in our hospital during the Coronavirus disease-2019 (COVID-19) pandemic. It was also investigated whether the patients hospitalized with a provisional diagnosis of CCHF who tested negative for CCHF PCR were infected with COVID-19. In our study, data (epidemiological, clinical, laboratory, prognosis) from 38 patients diagnosed with CCHF through reverse-transcriptase polymerase chain reaction (PCR) and viral-RNA and/or Immunoglobulin M antibodies using ELISA between May 2020 and November 2022 were investigated retrospectively. Of all the patients, 23 were CCHF PCR (+) and 15 were CCHF PCR (-).15 (65.2%) of PCR (+) patients and 9 (60%) of PCR (-) patients were engaged in farming. 65.2% of PCR (+) and 26.7% of PCR (-) patients presented with a history of tick bites. 21 (91.3%) of PCR (+) and 12 (80%) of PCR (-) patients had a history of rural living. Among the PCR (+) patients, 65.2%, 17.4%, and 17.4% received treatment for CCHF in 2022, 2021, and 2020 respectively. 87% of PCR (+) and 60% of PCR (-) patients were discharged after full recovery. The most common symptoms were fever, diffuse body ache, weakness, and headache. Significant differences were found between PCR (+) and PCR (-) patients in terms of leukocytes, LDH, INR, NEU, PLT, fibrinogen, and NLR values. 3 patients hospitalized with a provisional diagnosis of CCHF tested negative for CCHF PCR and positive for COVID-19 PCR. Thoracic CT, clinical, and laboratory findings of these patients showed no differences from the other patients. The possibility of misdiagnosis should be considered in CCHF and COVID-19 infections due to their similar symptoms and indications. Extensive multicentric studies need to be conducted to investigate the causes of the increased number of CCHF cases during the pandemic.
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Creswell, Cathy, Susan Cruddace, Stephen Gerry, Rachel Gitau, Emma McIntosh, Jill Mollison, Lynne Murray, et al. "Treatment of childhood anxiety disorder in the context of maternal anxiety disorder: a randomised controlled trial and economic analysis." Health Technology Assessment 19, no. 38 (May 2015): 1–184. http://dx.doi.org/10.3310/hta19380.
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BackgroundCognitive–behavioural therapy (CBT) for childhood anxiety disorders is associated with modest outcomes in the context of parental anxiety disorder.ObjectivesThis study evaluated whether or not the outcome of CBT for children with anxiety disorders in the context of maternal anxiety disorders is improved by the addition of (i) treatment of maternal anxiety disorders, or (ii) treatment focused on maternal responses. The incremental cost-effectiveness of the additional treatments was also evaluated.DesignParticipants were randomised to receive (i) child cognitive–behavioural therapy (CCBT); (ii) CCBT with CBT to target maternal anxiety disorders [CCBT + maternal cognitive–behavioural therapy (MCBT)]; or (iii) CCBT with an intervention to target mother–child interactions (MCIs) (CCBT + MCI).SettingA NHS university clinic in Berkshire, UK.ParticipantsTwo hundred and eleven children with a primary anxiety disorder, whose mothers also had an anxiety disorder.InterventionsAll families received eight sessions of individual CCBT. Mothers in the CCBT + MCBT arm also received eight sessions of CBT targeting their own anxiety disorders. Mothers in the MCI arm received 10 sessions targeting maternal parenting cognitions and behaviours. Non-specific interventions were delivered to balance groups for therapist contact.Main outcome measuresPrimary clinical outcomes were the child’s primary anxiety disorder status and degree of improvement at the end of treatment. Follow-up assessments were conducted at 6 and 12 months. Outcomes in the economic analyses were identified and measured using estimated quality-adjusted life-years (QALYs). QALYS were combined with treatment, health and social care costs and presented within an incremental cost–utility analysis framework with associated uncertainty.ResultsMCBT was associated with significant short-term improvement in maternal anxiety; however, after children had received CCBT, group differences were no longer apparent. CCBT + MCI was associated with a reduction in maternal overinvolvement and more confident expectations of the child. However, neither CCBT + MCBT nor CCBT + MCI conferred a significant post-treatment benefit over CCBT in terms of child anxiety disorder diagnoses [adjusted risk ratio (RR) 1.18, 95% confidence interval (CI) 0.87 to 1.62,p = 0.29; adjusted RR CCBT + MCI vs. control: adjusted RR 1.22, 95% CI 0.90 to 1.67,p = 0.20, respectively] or global improvement ratings (adjusted RR 1.25, 95% CI 1.00 to 1.59,p = 0.05; adjusted RR 1.20, 95% CI 0.95 to 1.53,p = 0.13). CCBT + MCI outperformed CCBT on some secondary outcome measures. Furthermore, primary economic analyses suggested that, at commonly accepted thresholds of cost-effectiveness, the probability that CCBT + MCI will be cost-effective in comparison with CCBT (plus non-specific interventions) is about 75%.ConclusionsGood outcomes were achieved for children and their mothers across treatment conditions. There was no evidence of a benefit to child outcome of supplementing CCBT with either intervention focusing on maternal anxiety disorder or maternal cognitions and behaviours. However, supplementing CCBT with treatment that targeted maternal cognitions and behaviours represented a cost-effective use of resources, although the high percentage of missing data on some economic variables is a shortcoming. Future work should consider whether or not effects of the adjunct interventions are enhanced in particular contexts. The economic findings highlight the utility of considering the use of a broad range of services when evaluating interventions with this client group.Trial registrationCurrent Controlled Trials ISRCTN19762288.FundingThis trial was funded by the Medical Research Council (MRC) and Berkshire Healthcare Foundation Trust and managed by the National Institute for Health Research (NIHR) on behalf of the MRC–NIHR partnership (09/800/17) and will be published in full inHealth Technology Assessment; Vol. 19, No. 38.
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Marks, I. M., K. Cavanagh, and L. Gega. "Computer-aided psychotherapy: revolution or bubble?" British Journal of Psychiatry 191, no. 6 (December 2007): 471–73. http://dx.doi.org/10.1192/bjp.bp.107.041152.
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SummaryResearch into computer-aided psychotherapy is thriving around the world. Most of it concerns computer-aided cognitive–behavioural therapy (CCBT). A recent narrative review found 97 computer-aided psychotherapy systems from nine countries reported in 175 studies, of which 103 were randomised controlled trials. The rapid spread of the mass delivery of psychotherapy through CCBT, catalysed in the UK by the National Institute for Health and Clinical Excellence's recommendation of two CCBT programmes and the Department of Health's CCBT implementation guidance, seems unprecedented. This editorial is a synopsis of the current status of CCBT and its future directions.
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Talah, Djamila, and Hamid Bentarzi. "A General Overview of Combined Cycle Gas Turbine Plants." Algerian Journal of Signals and Systems 7, no. 4 (December 29, 2022): 135–55. http://dx.doi.org/10.51485/ajss.v7i4.175.
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The Combined Cycle Gas Turbines (CCGT) has encountered a large diffusion over the last decades. Different researchers have focused on performance evaluation of CCGT through mathematical modeling techniques. Hence, there are some important factors which should be respected while modeling the CCGT. These factors include type of different components of the CCGT system, their configuration, the modeling methods, and the purpose of the modeling, the type and structure of the control system and the simulation objectives. Hence, a brief overview about CCGT design and technologies, mathematical modeling, simulation tools and methods are presented in this paper.
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J A, Ansari, Mumtaz A. Khan, Ranjha M A, Rathore T R, Khan G, Salman M, Nazia Hassan, Akram Qamar, and Aamer Ikram. "CRIMEAN CONGO HEMORRHAGIC FEVER IN PAKISTAN: CASE CONTROL STUDY, 2012-2015." Pakistan Journal of Public Health 8, no. 1 (May 16, 2018): 22–26. http://dx.doi.org/10.32413/pjph.v8i1.98.
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Background: Sporadic cases of CCHF continue to occur since first known fatality in 1976 in Pakistan. This study was conducted to identify the population groups more at risk to acquire CCHF infection. Methods: A case-control study comprising record review of the lab investigations sent to National Institute of Health, Islamabad was conducted from 2012 to 2015. A case was defined as any blood sample confirmed to be CCHF using RT-PCR testing. A total of 255 confirmed cases and 510 sex matched controls were randomly selected during January 2012-December 2015. Controls were selected from the samples which tested negative for CCHF on RTPCR. Data from all suspected cases were collected on a structured questionnaire. Univariate and multivariate analysis was conducted to find associations using Epi-Info and SPSS. Results: among 255 confirmed CCHF cases male were 80%. Baluchistan reported maximum number of cases (55%).The most affected age group was above 41 years (n=143, attack rate 0.45/100,000). In multivariate analysis the risk factors remained significantly associated with the CCHF were contact with Positive CCHF case (OR 3.77; 95% CI 2.49-5.71), health care workers (OR 3.76; 95% CI 2.22-6.36), butchers (OR 2.97; 95% CI 1.19-4.3.25), animal handlers (OR 2.55; 95% CI 1.12-2.72) and tannery workers (OR 2.13; 95% CI 1.22-2.72). Drivers and persons with travel history to endemic areas were significant in univaraite analysis but remained insignificant in multivariate analysis. Conclusion: Contact with the positive CCHF case and workers like health care professionals, butchers, animal handlers and tannery workers are at increased risk for CCHF. Educational intervention is recommended to control the CCHF.
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Duarte, A., S. Walker, E. Littlewood, S. Brabyn, C. Hewitt, S. Gilbody, and S. Palmer. "Cost-effectiveness of computerized cognitive–behavioural therapy for the treatment of depression in primary care: findings from the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial." Psychological Medicine 47, no. 10 (February 23, 2017): 1825–35. http://dx.doi.org/10.1017/s0033291717000289.
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BackgroundComputerized cognitive–behavioural therapy (cCBT) forms a core component of stepped psychological care for depression. Existing evidence for cCBT has been informed by developer-led trials. This is the first study based on a large independent pragmatic trial to assess the cost-effectiveness of cCBT as an adjunct to usual general practitioner (GP) care compared with usual GP care alone and to establish the differential cost-effectiveness of a free-to-use cCBT programme (MoodGYM) in comparison with a commercial programme (Beating the Blues) in primary care.MethodCosts were estimated from a healthcare perspective and outcomes measured using quality-adjusted life years (QALYs) over 2 years. The incremental cost-effectiveness of each cCBT programme was compared with usual GP care. Uncertainty was estimated using probabilistic sensitivity analysis and scenario analyses were performed to assess the robustness of results.ResultsNeither cCBT programme was found to be cost-effective compared with usual GP care alone. At a £20 000 per QALY threshold, usual GP care alone had the highest probability of being cost-effective (0.55) followed by MoodGYM (0.42) and Beating the Blues (0.04). Usual GP care alone was also the cost-effective intervention in the majority of scenario analyses. However, the magnitude of the differences in costs and QALYs between all groups appeared minor (and non-significant).ConclusionsTechnically supported cCBT programmes do not appear any more cost-effective than usual GP care alone. No cost-effective advantage of the commercially developed cCBT programme was evident compared with the free-to-use cCBT programme. Current UK practice recommendations for cCBT may need to be reconsidered in the light of the results.
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Hülya, Yilmaz, Gürdal Yilmaz, Ugur Kostakoglu, Mustafa Arslan, Süleyman Caner Karahan, and Iftihar Koksal. "Evaluation of Serum TNF-alpha, IL-6, IL-10, and IFN-gamma Levels in Patients with Crimean–Congo Hemorrhagic Fever." Open Forum Infectious Diseases 4, suppl_1 (2017): S312—S313. http://dx.doi.org/10.1093/ofid/ofx163.730.
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Abstract Background Crimean–Congo hemorrhagic fever (CCHF) is a potentially fatal disease caused by a tick-borne virus from the Bunyaviridae family. Cytokines plays an important role in the pathogenesis of viral, bacterial, and immunologic diseases. This study aimed to investigate the role of TNF-alpha, IL-6, IL-10, and IFN-gamma levels in the severity of infection and clinical outcome of patients with CCHF. Methods Patients with confirmed CCHF were divided into two groups (severe cases: Patients who exhibited hemorrhage during their hospital stay, and mild/moderate cases: Patients who displayed no hemorrhage during their hospital stay). Demographic characteristics, laboratory tests on admission of all patients with CCHF were investigated, and serum TNF-alpha, IL-6, IL-10, and IFN-gamma levels were measured. Results A total of 154 patients with confirmed CCHF were investigated. Forty-six (29.9%) of these patients were in the severe group. In patients with severe CCHF, significantly higher serum levels of TNF-alpha (68.2 ± 23.5; P = 0.008) and IL-6 (73.1 ± 41.6; P = 0.003) were detected, compared with cytokine levels in patients who mild/moderate CCHF (Table 1). No differences in serum IL-10 and IFN-gamma levels between patients who severe CCHF and those who mild/moderate CCHF were detected (P > 0.05). Conclusion Cytokines, chemokines, and other inflammatory mediators function in a manner, acting on many different cell types to regulate the host’s immune response. When cytokines present in high concentrations, they might toxic or even lethal effects. In accordance with this view, we have detected increased serum TNF-alpha, IL-6 levels in the patients with severe CCHF. Disclosures All authors: No reported disclosures.
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Peverengo, Luz, Luz Rodeles, Miguel Hernan Vicco, and Iván Marcipar. "The potential influence of atherogenic dyslipidemia on the severity of chronic Chagas heart disease." Revista da Associação Médica Brasileira 62, no. 1 (February 2016): 45–47. http://dx.doi.org/10.1590/1806-9282.62.01.45.
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SUMMARY Introduction: chronic Chagas heart disease (CCHD) is the most common manifestation of American Trypanosomiasis, causing about 50,000 deaths annually. Several factors bear correlation with the severity of CCHD. However, to our knowledge, the assessment on the contribution of major cardiovascular risk factors (CRF), such as hypertension and atherogenic dyslipidemia (AD) to CCHD severity is scarce, despite their well-established role in coronary artery disease, heart failure and stroke. Objective: to explore the potential relationship of blood pressure and AD with the clinical profile of patients with CCHD. Methods: we performed a cross-sectional study in T. cruziseropositive patients categorized according to a standard CCHD classification. All individuals were subjected to complete clinical examination. Autoantibodies induced by T. cruzi were assessed by ELISA. Results: we observed that Atherogenic index (AI) levels rose significantly in relation to the severity of the CCHD stage, with CCHD III cases showing the highest values of AI. Furthermore, those patients with globally dilated cardiomyopathy with reduced ejection fraction showed higher levels of AI. In regard to autoantibodies, anti-B13 also showed relation with the severity of the disease. Conclusion: we observed that AI correlated with CCHD stages and contributed, in association with anti-B13 antibodies and age, to the prediction of systolic heart failure.
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Waller, R., and S. Gilbody. "Barriers to the uptake of computerized cognitive behavioural therapy: a systematic review of the quantitative and qualitative evidence." Psychological Medicine 39, no. 5 (September 24, 2008): 705–12. http://dx.doi.org/10.1017/s0033291708004224.
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BackgroundStudies of cognitive behavioural therapy delivered by computer (cCBT) show clinical efficacy for treating anxiety and depression, but have not focused on barriers to uptake. Potential barriers include adverse consequences, accessibility and acceptability.MethodAn integrated systematic review was conducted of quantitative and qualitative studies and surveys from multiple electronic databases where computers delivered cCBT for anxiety or depression.ResultsSubstantial numbers of potential participants are lost prior to trials commencing with little explanation. Among trial participants, drop-outs may be higher in the cCBT groups (odds ratio 2.03, 95% confidence interval 0.81–5.09). Only a median of 56% completed a full course of cCBT and personal circumstance was a more common cause of drop-out than difficulties with the technology or social background. Risk was rarely assessed in the majority of programs. Significant staff time was needed to support clients. Therapists were more negative about cCBT than clients.ConclusionsWhile cCBT is likely to be an effective and acceptable intervention for some people, there are barriers to its uptake that will substantially limit its impact if not addressed. These included investigating the outcome and attitudes of those who do not make it as far as cCBT trials and why so few finish a full course of cCBT.
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Shen, Jianfei, Fengyun Li, Di Shi, Hongze Li, and Xinhua Yu. "Factors Affecting the Economics of Distributed Natural Gas-Combined Cooling, Heating and Power Systems in China: A Systematic Analysis Based on the Integrated Decision Making Trial and Evaluation Laboratory-Interpretative Structural Modeling (DEMATEL-ISM) Technique." Energies 11, no. 9 (September 3, 2018): 2318. http://dx.doi.org/10.3390/en11092318.
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As a clean and efficient energy, natural gas is the main driving force for China’s energy transformation and the realization of green energy development. Distributed natural gas combined cooling, heating and power (DNG-CCHP) is the main utilization method of distributed natural gas with many advantages. However, the economics of China’s DNG-CCHP system are poor, hindering the healthy and sustainable development of the system in China. Thus, this paper systematically analyzes the factors affecting the economics of DNG-CCHP system in China. Firstly, through the analysis of the development status and obstacles of China’s DNG-CCHP system, the economic impact factor set of DNG-CCHP systems involving 34 factors is constructed. Then, the integrated DEMTTEL-ISM method is used to construct the multi-level hierarchical structure of influencing factors, the influence mechanism of the factors on the economics of DNG-CCHP system is systematically and comprehensively analyzed, and the path of improving system economics is proposed accordingly. Finally, based on the research findings and the development of China’s DNG-CCHP, the coordinated development of DNG-CCHP and distributed renewable energy was discussed, and several policy suggestions are put forward to contribute to the integration of distributed natural gas and distributed renewable energy.
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Bigagli, Elisabetta, Maura Lodovici, Marzia Vasarri, Marta Peruzzi, Niccolò Nassi, and Donatella Degl’Innocenti. "Significance of Serum Oxidative and Antioxidative Status in Congenital Central Hypoventilation Syndrome (CCHS) Patients." Antioxidants 11, no. 8 (July 30, 2022): 1497. http://dx.doi.org/10.3390/antiox11081497.
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Congenital central hypoventilation syndrome (CCHS) is a rare neurological genetic disorder that affects sleep-related respiratory control. Currently, no drug therapy is available. In light of this, there is a need for lifelong ventilation support, at least during sleep, for these patients. The pathogenesis of several chronic diseases is influenced by oxidative stress. Thus, determining oxidative stress in CCHS may indicate further disorders in the course of this rare genetic disease. Liquid biopsies are widely used to assess circulating biomarkers of oxidative stress. In this study, ferric reducing ability of plasma, thiobarbituric acid-reactive substances, advanced oxidation protein products (AOPPs), and advanced glycation end-products were measured in the serum of CCHS patients to investigate the relationship between oxidative stress and CCHS and the significance of this balance in CCHS. Here, AOPPs were found to be the most relevant serum biomarker to monitor oxidative stress in CCHS patients. According to this communication, CCHS patients may suffer from other chronic pathophysiological processes because of the persistent levels of AOPPs.