Relevant bibliographies by topics / CcdA antitoxin

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  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'CcdA antitoxin'

Author: Grafiati
Published: 6 September 2023
Last updated: 31 July 2025

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Journal articles on the topic "CcdA antitoxin"

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Aguirre-Ramírez, Marisela, Jesús Ramírez-Santos, Laurence Van Melderen, and M. Carmen Gómez-Eichelmann. "Expression of the F plasmid ccd toxin–antitoxin system in Escherichia coli cells under nutritional stress." Canadian Journal of Microbiology 52, no. 1 (2006): 24–30. http://dx.doi.org/10.1139/w05-107.

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The ccd system of the F plasmid encodes CcdB, a protein toxic to DNA-gyrase, and CcdA, its antitoxin. The function attributed to this system is to contribute to plasmid stability by killing bacteria that lose the plasmid during cell division. However, the function of ccd in resting bacteria is not clear. Results presented show that ccd transcription increases as bacteria enter stationary phase and that the amount of the Ccd proteins is higher in bacteria under nutritional stress than in growing bacteria. Moreover, an increase in the frequency of Lac+ "adaptive" mutations was observed in statio
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Burger, Virginia M., Alexandra Vandervelde, Jelle Hendrix, et al. "Hidden States within Disordered Regions of the CcdA Antitoxin Protein." Journal of the American Chemical Society 139, no. 7 (2017): 2693–701. http://dx.doi.org/10.1021/jacs.6b11450.

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Madl, Tobias, Laurence Van Melderen, Natacha Mine, et al. "Structural Basis for Nucleic Acid and Toxin Recognition of the Bacterial Antitoxin CcdA." Journal of Molecular Biology 364, no. 2 (2006): 170–85. http://dx.doi.org/10.1016/j.jmb.2006.08.082.

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Lepka, Daniela, Tobias Kerrinnes, Evelyn Skiebe, Birgitt Hahn, Angelika Fruth, and Gottfried Wilharm. "Adding toYersinia enterocoliticaGene Pool Diversity: Two Cryptic Plasmids from a Biotype 1A Isolate." Journal of Biomedicine and Biotechnology 2009 (2009): 1–10. http://dx.doi.org/10.1155/2009/398434.

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We report the nucleotide sequence of two novel cryptic plasmids (4357 and 14 662 base pairs) carried by aYersinia enterocoliticabiotype 1A strain isolated from pork. As distinguished from most biotype 1A strains, this isolate, designated 07-04449, exhibited adherence to eukaryotic cells. The smaller plasmid pYe4449-1 carries five attributable open reading frames (ORFs) encoding the first CcdA/CcdB-like antitoxin/toxin system described for aYersiniaplasmid, a RepA-like replication initiation protein, and mobilizing factors MobA and MobC. The deduced amino acid sequences showed highest similarit
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Kwak, Yee Gyung, George A. Jacoby, and David C. Hooper. "Effect of Qnr on Plasmid Gyrase Toxins CcdB and ParE." Antimicrobial Agents and Chemotherapy 59, no. 8 (2015): 5078–79. http://dx.doi.org/10.1128/aac.00524-15.

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ABSTRACTPlasmid toxins CcdB and ParE are part of addiction systems promoting plasmid maintenance. Both target host DNA gyrase, as do quinolones and plasmid-determined Qnr proteins that protect gyrase from quinolone inhibition. We clonedqnrB4,qnrS1,ccdB,parE, and the antitoxin-encoding genesccdAandparDon compatible plasmids and tested them in combination. CcdB and ParE had no specific effect on quinolone susceptibility or Qnr protection, and Qnr did not act as a CcdB or ParE antitoxin.
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Cotrim, Camila Aparecida, Saulo Santesso Garrido, Eliane Trovatti, and Reinaldo Marchetto. "Síntese, caracterização e estudos de interação de um análogo da antitoxina CcdA empregando fluorescência no estado estacionário." Química Nova 33, no. 4 (2010): 841–45. http://dx.doi.org/10.1590/s0100-40422010000400014.

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Wu, Alma Y., Muhammad Kamruzzaman, and Jonathan R. Iredell. "Specialised functions of two common plasmid mediated toxin-antitoxin systems, ccdAB and pemIK, in Enterobacteriaceae." PLOS ONE 15, no. 6 (2020): e0230652. http://dx.doi.org/10.1371/journal.pone.0230652.

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Isaeva, A. S., E. E. Kulikov, N. V. Ravin, B. D. Dorokhov, K. K. Tarasyan, and A. V. Letarov. "Application of the new ccdAB-type natural toxin-antitoxin module for stabilization of inheritance of expressive plasmid vectors based on the bacteriophage N15 replicon in Escherichia coli cells." Microbiology 79, no. 5 (2010): 638–45. http://dx.doi.org/10.1134/s0026261710050085.

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Hudson, Lauren K., Lisha Constantine-Renna, Linda Thomas, et al. "Genomic characterization and phylogenetic analysis of Salmonella enterica serovar Javiana." PeerJ 8 (November 20, 2020): e10256. http://dx.doi.org/10.7717/peerj.10256.

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Salmonella enterica serovar Javiana is the fourth most reported serovar of laboratory-confirmed human Salmonella infections in the U.S. and in Tennessee (TN). Although Salmonella ser. Javiana is a common cause of human infection, the majority of cases are sporadic in nature rather than outbreak-associated. To better understand Salmonella ser. Javiana microbial population structure in TN, we completed a phylogenetic analysis of 111 Salmonella ser. Javiana clinical isolates from TN collected from Jan. 2017 to Oct. 2018. We identified mobile genetic elements and genes known to confer antibiotic r
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Yang, Chenguang, Zhenhua Fan, Lvming Wu, Bo Fu, and Hongbin Sun. "Purification and characterization of CcdB and CcdA toxin-antitoxin system from Acetobacter malorum." Bioscience, Biotechnology, and Biochemistry, April 26, 2025. https://doi.org/10.1093/bbb/zbaf063.

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Abstract The Toxin-Antitoxin (TA) system, a genetic element in microorganisms, consists of a stable toxin and an unstable antitoxin. The CcdAB system, a typical TA system, encodes the CcdB toxin and CcdA antitoxin and was identified in Acetobacter, though its biological role remains unclear. In this study, CcdA and CcdB proteins were successfully expressed, and purification conditions were optimized to obtain high-purity proteins. Their interaction was studied using a pull-down assay and confirmed through bioinformatics tools, revealing stable secondary structures. Induced expression of CcdB i
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Dissertations / Theses on the topic "CcdA antitoxin"

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Saavedra, De Bast Manuel. "Systèmes Ta de la famille ccd, de simples gènes égoïstes?" Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210045.

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Les systèmes toxine-antitoxine (TA) sont très répandus au sein des génomes bactériens. Ces opérons bicistroniques de petite taille ont été découverts sur des plasmides à bas nombre de copies. Dans ce contexte génétique, les systèmes TA confèrent un avantage sélectif à leurs molécules-hôtes en tuant les bactéries-filles qui ne les ont pas héritées par le mécanisme de tuerie post-ségrégationnelle (PSK, post-segregational killing). Ces systèmes génétiques sont également appelés modules d’addiction étant donné qu’ils rendent la descendance des bactéries qui les contiennent dépendantes de leur prés
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Wilbaux, Myriam. "Le système toxine-antitoxine ccdO157 d'Escherichia coli: caractérisation fonctionelle et distribution." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210503.

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Les systèmes toxine-antitoxine (TA) bactériens ont été découverts il y a une vingtaine d’année sur les plasmides à bas nombre de copie. Ils sont composés de deux gènes organisés en opéron, l’un codant pour une toxine stable et l’autre pour une antitoxine instable capable de neutraliser l’effet de la toxine. Les systèmes TA sont fortement représentés au sein de l’ensemble des génomes bactériens. Ils se localisent aussi bien sur des éléments génétiques mobiles (plasmides, phages, transposons,…) que dans les chromosomes, ce qui suggère que le transfert horizontal de gènes participe à leur dissémi
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Tandon, Himani. "Computational studies on interacting proteins with special reference to toxin-antitoxin systems." Thesis, 2019. https://etd.iisc.ac.in/handle/2005/4971.

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Proteins interact with other proteins to maintain functional homeostasis of the cell by tightly regulating cellular processes. Hence, it becomes important to understand not only the downstream effects of protein-protein interactions (PPIs), but its impact on interacting partners too. Much of the work embodied in this thesis pertains to sequence, structure, dynamics and functional analysis of protein-protein complexes. Firstly, the impact of PPIs on structure and dynamics of individual interacting partners was studied using a dataset of 58 protein-protein complexes of known 3-D structure. It wa
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Guptha, Kritika. "Molecular Determinants of Mutant Phenotypes in the CcdAB Toxin -Antitoxin System." Thesis, 2017. http://etd.iisc.ernet.in/2005/3634.

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A major challenge in biology is to understand and predict the effect of mutations on protein structure, stability and function. Chapter 1 provides a general introduction on protein sequence-structure relationships and use of the CcdAB toxin-antitoxin system as a model to study molecular determinants of mutant phenotypes. In Chapter 2, we describe the use of saturation mutagenesis combined with deep sequencing to determine phenotypes for 1664 single-site mutants of the E. coli cytotoxin, CcdB. We examined multiple expression levels, effects of multiple chaperones and proteases and employed exte
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Guptha, Kritika. "Molecular Determinants of Mutant Phenotypes in the CcdAB Toxin -Antitoxin System." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3634.

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A major challenge in biology is to understand and predict the effect of mutations on protein structure, stability and function. Chapter 1 provides a general introduction on protein sequence-structure relationships and use of the CcdAB toxin-antitoxin system as a model to study molecular determinants of mutant phenotypes. In Chapter 2, we describe the use of saturation mutagenesis combined with deep sequencing to determine phenotypes for 1664 single-site mutants of the E. coli cytotoxin, CcdB. We examined multiple expression levels, effects of multiple chaperones and proteases and employed exte
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Wang, Ling Yi, and 王齡苡. "CcdAB(Sm), a Chromosomal Toxin-Antitoxin Module, Mediates Cell Death in Serratia marcescens Multicellular Behavior." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/64863291456604535525.

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碩士<br>長庚大學<br>醫學生物技術暨檢驗學系<br>98<br>Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its cognate antitoxin and are found on the chromosomes of many bacteria including pathogens. It has been demonstrated that chromosomal TA systems influence bacterial multicellular behaviors such as biofilm formation and fruiting body formation. However, the role of TA systems in swarming behavior, another type of bacterial multicellular behavior, remains elusive. Swarming is a complex multicellular behavior requires the integration of chemical and physical signals, which leads to the physi
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Bhowmick, Jayantika. "CcdB : Stability, folding and application to design novel antibacterials." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/5134.

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The primary amino acid sequence typically dictates the ultimate conformation of the protein. Mutations in the sequence demonstrate neutral, positive or negative effects on the structure-function relationship of the protein. Destabilising mutations often reduce the soluble levels of the protein in vivo, leading to complete or partial loss of its function. Global suppressors are diverse compensatory mutations that can alleviate the detrimental effects of multiple destabilised, inactive mutants, despite being physically distant from the site of the original inactive mutations. The molecular mecha
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Book chapters on the topic "CcdA antitoxin"

1

Deghorain, Marie, Nathalie Goeders, Thomas Jové, and Laurence Van Melderen. "Type II Toxin-Antitoxin Loci: The ccdAB and parDE Families." In Prokaryotic Toxin-Antitoxins. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-33253-1_4.

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Journal articles
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