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Mariana, MUZYCHUK, and FOMINA Olena. "CbC-REPORTING IN TAX ADMINISTRATION." Foreign trade: economics, finance, law 116, no. 3 (June 15, 2021): 64–76. http://dx.doi.org/10.31617/zt.knute.2021(116)06.
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Background. Countering the erosion of the tax base through the use of transfer pricing (TP) is an important element of tax policy. Ukraine is implementing three-level TP reporting and the procedure of automatic exchange of tax information. The analysis of recent research and publications has showedthat research on the use of data obtained in the exchange of tax information procedure under the CbC standard is relevant and controversial. The aim of the articleis to investigate the conditions for the introduction of automatic information exchange in Ukraine and provide recommendations for the practical use of the obtained data for tax control purposes. Results. An analysis of the structure of three-level TP reporting and the conditions of its first submission in Ukraine was performed. The procedure of automatic exchange of tax information according to the CbCR standard is considered. Based on the results of this study, a set of proposals for the use of CbC reporting data for tax administration purposes has been developed. The implementation of these proposals will help strengthen tax control and administration. Conclusion. The information received under CbCR-standard is intended for comprehensive analysis and risk identification by tax administrations and cannot be an alternative to tax audits or investigations. The obtained results can be used to build the business processes on CbC information application by the tax authorities. Further research in this direction should focus on the development of recommendations for the business process on the automatic exchange of information according to the CbCR standard establishment and the further use of the data obtained under this exchange by the tax administration.
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Novis, David A., and Jane C. Dale. "Morning Rounds Inpatient Test Availability." Archives of Pathology & Laboratory Medicine 124, no. 4 (April 1, 2000): 499–503. http://dx.doi.org/10.5858/2000-124-0499-mrita.
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Abstract Objectives.—To determine the success with which laboratories were able to report morning test results on time, the laboratory practice characteristics associated with improved success, and the degree of satisfaction among clinicians with the timeliness of laboratory service. Design.—Hospital laboratories participating in the College of American Pathologist Q-Probes laboratory quality improvement program prospectively calculated the percentages of morning-run complete blood cell count (CBC) and electrolyte results that were reported on or before predetermined reporting deadlines, completed questionnaires concerning their departments' practice characteristics as they related to performing morning blood work, and distributed to physician utilizers of morning laboratory services questionnaires evaluating physician satisfaction with laboratory services. Setting and Participants.—A total of 367 public and private institutions located in the United States (355), Canada (5), Australia (2), and 1 each in the United Kingdom, Spain, Brazil, Korea, and Guam. Main Outcome Measure.—The percentages of morning-run CBC and electrolyte results reported on or before predetermined reporting deadlines. Results.—Participants submitted data on 40 256 CBC and 39 604 electrolyte specimens. In aggregate, a total of 88.9% of these tests (90.2% of CBCs and 87.6% of electrolytes) were reported on or before the reporting deadlines that the participating laboratories set for themselves. Half of the participants reported 94.6% of their CBC results and 95.5% of their electrolyte results on or before their self-imposed reporting deadlines. No specific demographic features or departmental practice characteristics were associated with higher or lower rates of institutional reporting compliance. Most physician utilizers of early-morning laboratory test results believed that the laboratory is sensitive to and meets the needs of clinicians for timely reporting of early-morning test results. Conclusions.—Most laboratories are capable of reporting 95% of their routine morning laboratory tests on time, and most physicians are satisfied with their laboratories' morning testing service.
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Coskun, Abdurrahman, Federica Braga, Anna Carobene, Xavier Tejedor Ganduxe, Aasne K. Aarsand, Pilar Fernández-Calle, Jorge Díaz-Garzón Marco, et al. "Systematic review and meta-analysis of within-subject and between-subject biological variation estimates of 20 haematological parameters." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 1 (December 18, 2019): 25–32. http://dx.doi.org/10.1515/cclm-2019-0658.
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Abstract Background Interpretation of the complete blood count (CBC) parameters requires reliable biological variation (BV) data. The aims of this study were to appraise the quality of publications reporting BV data for CBC parameters by applying the BV Data Critical Appraisal Checklist (BIVAC) and to deliver global BV estimates based on BIVAC compliant studies. Methods Relevant publications were identified by a systematic literature search and evaluated for their compliance with the 14 BIVAC criteria, scored as A, B, C or D, indicating decreasing compliance. Global CVI and CVG estimates with 95% CI were delivered by a meta-analysis approach using data from BIVAC compliant papers (grades A–C). Results In total, 32 studies were identified; four received a BIVAC grade A, 2 B, 20 C and 6 D. Meta-analysis derived CVI and CVG estimates were generally lower or in line with those published in a historical BV database available online. Except for reticulocytes, CVI estimates of erythrocyte related parameters were below 3%, whereas platelet (except MPV and PDW) and leukocyte related parameters ranged from 5% to 15%. Conclusions A systematic review of CBC parameters has provided updated, global estimates of CVI and CVG that will be included in the newly published European Federation of Clinical Chemistry and Laboratory Medicine BV Database.
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Mlinaric, Ana, Marija Milos, Désirée Coen Herak, Mirjana Fucek, Vladimira Rimac, Renata Zadro, and Dunja Rogic. "Autovalidation and automation of the postanalytical phase of routine hematology and coagulation analyses in a university hospital laboratory." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 3 (February 23, 2018): 454–62. http://dx.doi.org/10.1515/cclm-2017-0402.
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AbstractBackground:The need to satisfy high-throughput demands for laboratory tests continues to be a challenge. Therefore, we aimed to automate postanalytical phase in hematology and coagulation laboratory by autovalidation of complete blood count (CBC) and routine coagulation test results (prothrombin time [PT], international normalized ratio [PT-INR], activated partial thromboplastin time [APTT], fibrinogen, antithrombin activity [AT] and thrombin time [TT]). Work efficacy and turnaround time (TAT) before and after implementation of automated solutions will be compared.Methods:Ordering panels tailored to specific patient populations were implemented. Rerun and reflex testing rules were set in the respective analyzers’ software (Coulter DxH Connectivity 1601, Beckman Coulter, FL, USA; AutoAssistant, Siemens Healthcare Diagnostics, Germany), and sample status information was transferred into the laboratory information system. To evaluate if the automation improved TAT and efficacy, data from manually verified results in September and October of 2015 were compared with the corresponding period in 2016 when autovalidation was implemented.Results:Autovalidation rates of 63% for CBC and 65% for routine coagulation test results were achieved. At the TAT of 120 min, the percentage of reported results increased substantially for all analyzed tests, being above 90% for CBC, PT, PT-INR and fibrinogen and 89% for APTT. This output was achieved with three laboratory technicians less compared with the period when the postanalytical phase was not automated.Conclusions:Automation allowed optimized laboratory workflow for specific patient populations, thereby ensuring standardized results reporting. Autovalidation of test results proved to be an efficient tool for improvement of laboratory work efficacy and TAT.
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Ziani, Idriss, Ahmed Ibrahimi, Omar Bellouki, Youssef Zaoui, Yasmine Laraqui Housseini, Fouad Zouidia, Hachem El Sayegh, Lounis Benslimane, and Yassine Nouini. "Medullary Aplasia Revealing a Metastatic Prostatic Adenocarcinoma." Case Reports in Urology 2021 (February 23, 2021): 1–5. http://dx.doi.org/10.1155/2021/8898130.
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In this case report, we are reporting the case of a 68-year-old male patient who was admitted in our hospital for unintended weight loss, asthenia, and anorexia. Physical examination showed clinical signs of anemia such as pallor of skin and mucous membranes; hemodynamic parameters were normal. Complete blood count (CBC) analysis showed a pancytopenia with anemia, thrombocytopenia, and leukopenia. BM biopsy was performed, showing a malignant infiltration of bone marrow by a metastatic prostate cancer confirmed by immunohistochemistry. Prostate biopsy confirmed the diagnosis of acinar adenocarcinoma with Gleason score 8 ( 4 + 4 ), ISUP grade group 4. Our patient underwent chemical castration using LH-RH analogs in association with second-line hormone therapy by abiraterone acetate. The evolution was good on both the oncological and hematological levels.
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Taj, Nadia, Saba Javed, Munazza Munir, Anam Naz, Asma Sajid, and Ayesha Karim. "Prevalence of iron deficiency and thalassemia in patients presenting Tertiary Care Hospital." Professional Medical Journal 27, no. 12 (December 10, 2020): 2618–21. http://dx.doi.org/10.29309/tpmj/2020.27.12.4643.
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Objectives: To find the frequency of iron deficient anemia and thalassemia in anemic patient reporting in tertiary hospital in Multan. Study Design: Cross Sectional study. Setting: Department of Obstetrics and Gynecology in Nishtar Hospital, Multan. Period: 20th October 2018 to 20th April 2019. Material & Method: In this study total 260 females with anemia HB<10.5g/dl were incorporated. Blood of all the patients were collected following the septic measures in CBC vial for counting of hemoglobin and blood investigation serum ferritin [<11ng/ml] and HB electrophoresis HBA [>6]. Gestational age was predicted depending upon last period of menstruation. Results: Age of patients in this study was between 24 to 34 year with the average age of 29.9±2.3 year, average gestational age 33.2±2.11 week, average parity 1.46±1.3. Iron deficient anemia was observed in 88.4 percent patient. Thalassemia was observed in 5.7 percent patient. Conclusion: The results of our study revealed that iron deficiency and thalassemia are significant contributing factors of anemia in patients reporting tertiary care hospitals Multan. General screening for carriers of thalassemia should be provided to all pregnant females attending prenatal care.
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Patel, Janhavi, Harsheev Desai, and Ali Okhowat. "The Role of the Canadian Media During the Initial Response to the COVID-19 Pandemic: A Topic Modelling Approach Using Canadian Broadcasting Corporation News Articles." JMIR Infodemiology 1, no. 1 (July 18, 2021): e25242. http://dx.doi.org/10.2196/25242.
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Background Beginning as a local epidemic, COVID-19 has since rapidly evolved into a pandemic. As countries around the world battle this outbreak, mass media has played an active role in disseminating public health information. Objective The aim of this study was to get a better understanding of the role that the Canadian media played during the pandemic and to investigate the patterns of topics covered by media news reporting. Methods We used a data set consisting of news articles published on the Canadian Broadcasting Corporation (CBC) website between December 2019 and May 2020. We then used Python software to analyze the data using Latent Dirichlet Allocation topic modelling. Subsequently, we used the pyLDAvis tool to plot these topics on a 2D plane through multidimensional scaling and divided these topics into different themes. Results After removing articles that were published before the year 2019, we identified 6771 relevant news articles. According to the CV coherence value, we divided these articles into 15 topics, which were categorized into 6 themes. The three most popular themes were case reporting and testing (n=1738), Canadian response to the pandemic (n=1259), and changes to social life (n=1171), which accounted for 25.67%, 18.59%, and 17.29% of the total articles, respectively. Conclusions Understanding the Canadian media’s reporting on the COVID-19 pandemic shows that the Canadian pandemic response is a product of consistent government communication, as well as the public’s understanding of and adherence to protocols.
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Ara, Tasneem, Qazi Smita Haque, and Salma Afrose. "A Rare Case of Congenital Methemoglobinemia with secondary polycythemia- Case Report and Literature Review." Haematology Journal of Bangladesh 3, no. 01 (December 14, 2019): 20–23. http://dx.doi.org/10.37545/haematoljbd201930.
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Congenital heart diseases are common cause of congenital cyanosis with polycythaemia. Congenital methemoglobinemia is a rare cause of lifelong cyanosis with polycythemia. Congenital methemoglobinemia is caused either by enzyme deficiency or by an abnormal Hb (Hb M). Asymptomatic despite presence of severe cyanosis indicates this rare disorder. We are reporting a rare case of polycythemia with cyanosis due to congenital methemoglobinemia. The patient was referred to our centre and attended Hematology OPD (out-patient department) when his routine CBC revealed erythrocytosis. At that time, we found him severely cyanosed especially apparent on lips, tongue, hands and feet. He was diagnosed as a case of congenital methemoglobinemia with 38% blood methemoglobin level (normal value-0.00-2.00%). On view of life long persistent cyanosis, without any cardiopulmonary and neurological abnormality, consanguinity of parent’s marriage, dark colored blood with high methemoglobin level, a final diagnosis of Type I enzyme deficiency congenital methemoglobinemia was made. He was treated with oral ascorbic acid 250 mg twice daily. At follow up after 6 months his skin color improved and RBC count returned to normal. We are reporting this case of congenital methemoglobinemia for the first time in Bangladesh to emphasize the importance of this rare entity in the differential diagnosis of asymptomatic cyanosis with polycythemia.
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Woolley, Bruce. "Teaching Undergraduate Journalism Students Foreign Correspondence: Can It Be Done?" Asia Pacific Media Educator 27, no. 1 (April 21, 2017): 85–102. http://dx.doi.org/10.1177/1326365x17701794.
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The University of Queensland has conducted five international field reporting courses in India and Vietnam since 2012,1 as well as three more courses based on similar work integrated learning principles (i.e., intensive, immersive and experiential) on campus at St Lucia in Brisbane during the same period. Previous research has found them to be valuable pedagogical innovations that have led to solid academic outcomes. The students themselves have also reported enjoying greater self-confidence, better reporting and technical skills, and increased employment prospects as a direct result of taking part in these courses. Some of that research is re-examined in this article but in a new light, given that the main focus here is on whether these courses in fact deliver on another important promise: to teach the core skills required of a foreign correspondent. To discover what those core skills might be, the researcher explored the extensive literature written by former and current correspondents about their experiences and their lessons learned. He also approached 12 former colleagues at the British Broadcasting Corporation (BBC), the Australian Broadcasting Corporation (ABC) and the Canadian Broadcasting Corporation (CBC), all of whom have been high profile international reporters, correspondents and producers, and invited them to offer their unstructured reflections on this question. These insights have then been filtered and assessed through the researcher’s own reflections of working as a foreign correspondent for the ABC in London between 1984 and 1987. The results are both encouraging and challenging. They suggest that while the students and their teachers are largely satisfied with the reporting, technical and personal skills that have been taught and learned, many correspondents consider that their core attributes include extensive experience in senior reporting roles prior to heading overseas, where the basic skills have been honed to the highest degree. That, of course, is something that no undergraduate could ever claim to have achieved.
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Rajesh, T. S., and A. N. Pallavi. "Congenital cavernous hemangioma of the skull - A rare case in infants." International Journal of Preclinical and Clinical Research 2, no. 1 (March 25, 2021): 28–30. http://dx.doi.org/10.51131/ijpccr/v2i1.2.
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Reporting a rare case of Calvarial Cavernous Hemangioma. A 2-months-oldmale baby presented with Right Frontal swelling noticed when baby was 20days old rapidly progressive in size. On examination, it was solitary 6*7cm firm irregular swelling fixed to bone which On CT/MRI showed 6*5*4cm mixed density extra axial lesion in right frontal region with bony destruction causing mass effect and mid line shift? neoplastic. Baby had no neurological deficits. CBC showed Pancytopenia. Patient was operated under GA, total excision of the lesion and margin of surrounding eroded bone was performed. Tumor was completely extradural. Histopathology showed Bony trabeculae separated by loose fibrocollagenous tissue enclosing many endothelium lined Vascular spaces. Post operative no recurrence is observed. Cavernous Hemangioma of skull is very rare in infancy and must be included in differential diagnosis of skull lesions . Untreated Cavernous Hemangiomas may show progression. A suspected Neoplastic swelling turned out to be benign lesion. Timely operative intervention prevented complications due to severe anemia because of intralesional bleed. Keywords: Calvaria; Cavernous Hemangioma; Benign
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Haider, Rana Zeeshan, Najeed Ahmed Khan, Eloisa Urrechaga, and Tahir Sultan Shamsi. "Mature and Immature/Activated Cells Fractionation: Time for a Paradigm Shift in Differential Leucocyte Count Reporting?" Diagnostics 11, no. 6 (May 21, 2021): 922. http://dx.doi.org/10.3390/diagnostics11060922.
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Leucocytes, especially neutrophils featuring pro- and anti-cancerous characteristics, are involved in nearly every stage of tumorigenesis. Phenotypic and functional differences among mature and immature neutrophil fractions are well reported, and their correlation with tumor progression and therapy has emerging implications in modern oncology practices. Technological advancements enabled modern hematology analyzers to generate extended information (research parameters) during complete blood cell count (CBC) analysis. We hypothesized that neutrophil and lymphocyte fractions-related extended differential leucocytes count (DLC) parameters hold superior diagnostic utility over routine modalities. The present study was carried out over a four-and-a-half-year period wherein extended neutrophil (immature granulocyte [IG] and mature neutrophil [NEUT#&]), and lymphocyte (activated/high fluorescence lymphocyte count [HFLC] and resting lymphocyte [LYMP#&]) parameters were challenged over routine neutrophil [NEUT#] and lymphocyte [LYMP#] items in a study population of 1067 hematological neoplasm patients. Extending the classical statistical approaches, machine-learning-backed data visualization was used to explore trends in the study parameters. As a whole, extended neutrophil and lymphocyte count outperformed and was diagnostically more relevant than routine neutrophil and lymphocyte parameters by showing the least difference from their respective (gold-standard) manual DLC counts. The mature neutrophil count was compared to IG, and resting lymphocyte count was compared to HFLC by calling the function ‘correlation’ as a ‘clustering function’ for heatmap based visualization. The aforementioned study parameters displayed close clustering (rearrangement) for their respective study items by presenting distinct trends of equally valuable weights (deviated values), advocating fractions-based extended DLC reporting. Importantly, using a Bland and Altman analysis analogously to a manual neutrophil count, the mature neutrophil count [NEUT#&] remained unbiased since a routine neutrophil count [NEUT#] was found to be a negatively biased. The extended DLC-parameter-driven fractions-based reporting has superior diagnostic utility over classical routine approaches; this finding can largely minimize labor-intensive manual DLC practices, especially in hematology–oncology departments.
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Kant, Sophy, Julian Walsh, Christopher R. Hall, Alison Rodger, and Gareth Mitchell. "An introduction to communicating science." New Directions in the Teaching of Physical Sciences, no. 3 (February 23, 2016): 27–32. http://dx.doi.org/10.29311/ndtps.v0i3.413.
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It is becoming increasingly recognised that students in Higher Education must acquire the skills necessary for professional and personal development, as well as for academic progress. The media have recently focused on the issue of declining public interest in the sciences and the lack of accurate reporting of science. We have developed a new programme, which endeavours to address both issues involving a three day intensive course covering writing, TV and radio. In addition to the targeted activities of learning the skills of science communication, the programme encourages partnerships, and exploits the resources and expertise available from various institutions. The undertaking of this type of programme is not limited to the acquisition of time slots in a studio such as Bush House. Most university campuses are now home to their own recording studios and even have television facilities. However, the programme requires only a video camera and audio recording equipment. The success of this science communication module and oftwo others run by MOAC and CBC (Team Development and Decision-making and Leadership) has encouraged us to develop a complete postgraduate certificate in transferable skills. We anticipate the certificate will be a valuable vehicle for consolidating and enhancing the training discussed in this article.
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Valenstein, Paul, and Molly Walsh. "Five-Year Follow-up of Routine Outpatient Test Turnaround Time: A College of American Pathologists Q-Probes Study." Archives of Pathology & Laboratory Medicine 127, no. 11 (November 1, 2003): 1421–23. http://dx.doi.org/10.5858/2003-127-1421-fforot.
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Abstract Context.—Timely reporting of outpatient tests can increase efficiency of care and improve customer satisfaction. Objectives.—We conducted a survey in 2002 to determine how quickly hospital-based laboratories turned around routine requests for 3 common assays and compared the results with a similar survey conducted in 1997. Design.—One hundred eighteen laboratories prospectively recorded the collection-to-verification turnaround time for 9252 complete blood cell counts (CBCs), 8832 thyroid tests, and 9193 basic metabolic panels. Results.—The median facility reported all test results by 7:00 am of the weekday immediately after the date of specimen collection. The bottom 10% of institutions reported 99% of CBCs and basic metabolic panels within 1 day and 60% of thyroid tests within 1 day. The 65 institutions that participated in both the 1997 and 2002 surveys showed significant overall improvement in turnaround time for all 3 types of tests (P < .001). In 2002, federal institutions had significantly slower turnaround times than nonfederal institutions for CBC tests (P < .001), thyroid tests (P = .03), and basic metabolic panels (P < .001). Other demographic and practice variables were not associated with turnaround time. Conclusion.—The turnaround time of routine outpatient tests appears to have improved between 1997 and 2002.
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Giridharan, Guruprasad A., Michael A. Sobieski, Mickey Ising, Mark S. Slaughter, and Steven C. Koenig. "Blood Trauma Testing For Mechanical Circulatory Support Devices." Biomedical Instrumentation & Technology 45, no. 4 (July 1, 2011): 334–39. http://dx.doi.org/10.2345/0899-8205-45.4.334.
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Abstract Preclinical hemolysis testing is a critical requirement toward demonstrating device safety for U.S. Food and Drug Administration (FDA) 510(k) approval of mechanical circulatory support devices (MCSD). FDA and ASTM (formerly known as the American Society for Testing and Materials) have published guidelines to assist industry with developing study protocols. However, there can be significant variability in experimental procedures, study design, and reporting of data that makes comparison of test and predicate devices a challenge. To overcome these limitations, we present a hemolysis testing protocol developed to enable standardization of hemolysis testing while adhering to FDA and ASTM guidelines. Static mock flow loops primed with fresh bovine blood (600 mL, Hematocrit = 27±5%, heparin titrated for ACT >300 sec) from a single-source donor were created as a platform for investigating test and predicate devices. MCSD differential pressure and temperature were maintained at 80 mmHg and 25°±2° C. Blood samples (3 ml) were collected at 0, 5, 90, 180, 270, 360 minutes to measure CBC and plasma free hemoglobin. This protocol led to 510(k) approval of two adult MCSD and has been used to test novel cannulae and a pediatric MCSD. Standardization of hemolysis testing procedures and transparency of results may enable better blood trauma characterization of MCS devices to facilitate the FDA 510(k) and PMA submission processes and improve clinical outcomes.
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Soderlund, Walter C., Ronald H. Wagenberg, and Ian C. Pemberton. "Cheerleader or Critic? Television News Coverage in Canada and the United States of the US Invasion of Panama." Canadian Journal of Political Science 27, no. 3 (September 1994): 581–604. http://dx.doi.org/10.1017/s0008423900017911.
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AbstractThe role of mass media in reporting United States military operations is a subject on which there is considerable interest as well as diversity of opinion. The significance of media coverage has been recognized by both supporters and opponents of American use of military force to achieve foreign policy objectives. However, analysts disagree on whether the media tend to be supportive or critical of such ventures.This study examines the above question with respect to the US invasion of Panama which began on December 20, 1989. Coverage of the invasion by three American networks (ABC, CBS and NBC) and two Canadian networks (CBC and CTV) in their major nightly television newscasts was compared for a 23-day period from December 15, 1989 to January 6, 1990. The data set picks up material on Panama beginning five days prior to the invasion and continues for three days following the surrender of General Noriega. In total 197 news stories are analyzed.Examined in the study are factors such as volume of coverage (number of stories and running time); placement of items in the newscast; substantive issues given prominence; news sources utilized, and whether these sources were favourable or unfavourable toward US foreign policy positions; positive and negative “images” presented of the key actors involved in the invasion (Manuel Noriega, Guillermo Endara and George Bush); and whether overall, in both text and visual impact, the story was likely to be interpreted as either pro- or anti-invasion by viewers.
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Sinha, Sudha, Brian Trainor, and Robert Weinstein. "On the Resurgence of the Hematologist as Consultant to Primary Care Practitioners." Blood 104, no. 11 (November 16, 2004): 3144. http://dx.doi.org/10.1182/blood.v104.11.3144.3144.
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Abstract The widespread use of “routine” automated blood testing in primary care practice appears to have increased the demand for consultative services by hematologists. To explore this hypothesis, we tracked consecutive first-time referrals to our university hospital hematology clinic retrospectively between July 2002 and June 2003 and prospectively from July 2003 to May 2004. Findings were similar in both time intervals and thus are combined for reporting. Of 557 consultative referrals, 326 patients (58.5 %) were referred for abnormalities of the peripheral blood counts, 209 (64%) of which were detected as incidental findings in asymptomatic patients. 144 (26%) of all referrals were for anemia and 79 (55%) of those proved to have primary medical conditions including active alcoholism, medication effects, chronic renal failure, iron deficiency, chronic inflammatory diseases or advanced liver disease. The rest had hematological disorders including, myelodysplastic syndromes, hemoglobinopathies, hemolytic anemias, and others. 66 (12%) of all referrals were for abnormalities of the white blood cell count and only 24 (36%) turned out to have a primary hematological disorder (e.g. CLL, CML or benign chronic leukopenia). The other 42 (64%) had primary medical disorders including leukocytosis of smoking or pregnancy, allergies, anti-convulsant-related leukopenia, etc. 50 patients were referred for thrombocytopenia or thrombocytosis, of which 29 (58%) had primary medical disorders including iron deficiency or inflammatory states, gestational thrombocytopenia, known hypersplenism, medication-related thrombocytopenia, or alcoholism. Similarly 20 of the 40 patients referred for bi- or pancytopenias had primary hematological disorders and 20 had medical disorders that included hypersplenism, drugs, or mild disorders that resolved by the time of referral. The remaining 231 patients (41.5%) included 69 who were referred for evaluation of, and counseling for, hypercoagulable disorders, 39 referred for presumed bleeding disorders (4 had senile purpura; 9 had storage pool disorders), 9 with hereditary hemochromatosis, 51 with hematological malignancies, 12 with unexplained lymphadenopathy (8 with infectious mononucleosis or other reactive lymphadenopathy, 1 with enlarged tonsils, 1 CLL, 1 T-cell lymphoma, 1 Kimura’s disease) and 9 patients with polyclonal hyperglobulinemia. Overall, only 45 % of the patients referred for consultation turned out to have a primary hematological disorder. The rest had conditions that are traditionally considered to be in the realm of internal medicine or primary care. Most consults were initiated based on incidental abnormalities of the CBC that were not, or could not be, worked up by the referring physician. Thus primary care practitioners are relying on hematologists to explain routine findings in often-asymptomatic patients with fortuitous abnormalities of the peripheral blood counts. Medical surveillance of asymptomatic patients is likely to result in progressively early detection of subtle changes in the CBC that internists and others will rely on hematologists to explain. Thus the hematologist’s role as consultant continues to expand.
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Haussmann, Jan, Wilfried Budach, Vratislav Strnad, Stefanie Corradini, David Krug, Livia Schmidt, Balint Tamaskovics, et al. "Comparing Local and Systemic Control between Partial- and Whole-Breast Radiotherapy in Low-Risk Breast Cancer—A Meta-Analysis of Randomized Trials." Cancers 13, no. 12 (June 13, 2021): 2967. http://dx.doi.org/10.3390/cancers13122967.
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Purpose/Objective: The standard treatment for localized low-risk breast cancer is breast-conserving surgery, followed by adjuvant radiotherapy and appropriate systemic therapy. As the majority of local recurrences occur at the site of the primary tumor, numerous trials have investigated partial-breast irradiation (PBI) instead of whole-breast treatment (WBI) using a multitude of irradiation techniques and fractionation regimens. This meta-analysis addresses the impact on disease-specific endpoints, such as local and regional control, as well as disease-free survival of PBI compared to that of WBI in published randomized trials. Material and Methods: We conducted a systematic literature review and searched for randomized trials comparing WBI and PBI in early-stage breast cancer with publication dates after 2009. The meta-analysis was based on the published event rates and the effect sizes for available oncological endpoints of at least two trials reporting on them. We evaluated in-breast tumor recurrences (IBTR), local recurrences at the primary site and elsewhere in the ipsilateral breast, regional recurrences (RR), distant metastasis-free interval (DMFI), disease-free survival (DFS), contralateral breast cancer (CBC), and second primary cancer (SPC). Furthermore, we aimed to assess the impact of different PBI techniques and subgroups on IBTR. We performed all statistical analyses using the inverse variance heterogeneity model to pool effect sizes. Results: For the intended meta-analysis, we identified 13 trials (overall 15,561 patients) randomizing between PBI and WBI. IBTR was significantly higher after PBI (OR = 1.66; CI-95%: 1.07–2.58; p = 0.024) with an absolute difference of 1.35%. We detected significant heterogeneity in the analysis of the PBI technique with intraoperative radiotherapy resulting in higher local relapse rates (OR = 3.67; CI-95%: 2.28–5.90; p < 0.001). Other PBI techniques did not show differences to WBI in IBTR. Both strategies were equally effective at the primary tumor site, but PBI resulted in statistically more IBTRs elsewhere in the ipsilateral breast. IBTRs after WBI were more likely to be located at the primary tumor bed, whereas they appeared equally distributed within the breast after PBI. RR was also more frequent after PBI (OR = 1.75; CI-95%: 1.07–2.88; p < 0.001), yet we did not detect any differences in DMFI (OR = 1.08; CI-95%: 0.89–1.30; p = 0.475). DFS was significantly longer in patients treated with WBI (OR = 1.14; CI-95%: 1.02–1.27; p = 0.003). CBC and SPC were not different in the test groups (OR = 0.81; CI-95%: 0.65–1.01; p = 0.067 and OR = 1.09; CI-95%: 0.85–1.40; p = 0.481, respectively). Conclusion: Limiting the target volume to partial-breast radiotherapy appears to be appropriate when selecting patients with a low risk for local and regional recurrences and using a suitable technique.
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Khan, Mudussara A., Terri Walling, Aaron Cumpston, and Michael Craig. "CMV Colitis in a Patient Receiving Dasatinib." Blood 110, no. 11 (November 16, 2007): 4567. http://dx.doi.org/10.1182/blood.v110.11.4567.4567.
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Abstract Introduction: CMV generally produces an asymptomatic or minimally symptomatic acute illness in immunocompetent patients. CMV reactivation commonly occurs in patients with CML after allogeneic transplant but has not been described in those who are treated with tyrosine kinase inhibitors. We report a case of a patient with CML in lymphoid blast phase treated with dasatinib to cytogenetic remission that presented with CMV Colitis. Method: 73-year-old male diagnosed with CML in lymphoid blast crisis 2/2006 treated with chemotherapy and imatinib with good response. He relapsed in 2/2007 with leukostasis and underwent leukopharesis. His BCR/ABL mutation analysis was positive for F359V mutation conferring resistance to imatinib. He was started on dasatinib 70 mg twice daily and had a cytogenetic remission within four months. He presented five months after starting therapy with four weeks of recurrent fevers, chills, malnutrition and diarrhea. Results: CBC and differential revealed only mild thrombocytopenia, Absolute CD4 count of 209; absolute CD8 count of 1495. CMV DNA PCR Quantification of 1500 copies/ml. CT chest abdomen and pelvis showed right sided pleural effusion but no pneumonitis. Flex sigmoidoscopy showed inflamed edematous mucosa with submucosal hemorrhages scattered throughout colon and rectum. Pathology showed chronic colitis, focal viral cytopathic changes consistent with CMV presence. Presence of CMV was confirmed by immunoperoxidase stain for CMV. Treatment was started with IV ganciclovir then switched to oral valganciclovir with good response and resolution of CMV infection. Conclusion: CMV colitis is a well-known complication in immunocompromised hosts after HCT. We are reporting a case of CMV colitis in a patient with CML and had hematologic and cytogenetic remission on a novel tyrosine kinase inhibitor - dasatinib. CMV reactivation may occur in patients who are receiving dasatinib. Furthur evaluation is necessary to determine the incidence of this complication.
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Khalid, Attika, Sami Saeed, Madeeha Rehan, and Nadia Arif. "Platelet Indices as Potential Monitoring Biomarkers in COVID-19: A New Hope." Journal of Rawalpindi Medical College 25, no. 1 (March 30, 2021): 134–39. http://dx.doi.org/10.37939/jrmc.v25i1.1580.
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Objective: To investigate the relationship between established acute inflammatory markers in COVID-19 patients with Mean platelet volume (MPV) and Platelet large cell ratio (P-LCR).
Materials and Methods: This was a retrospective longitudinal study conducted at Fauji Foundation Hospital, Rawalpindi from 10th June to 10th August 2020. Biochemical parameters i.e. CRP, serum ferritin, LDH, and pro-BNP as well as hematological parameters (MPV and P-LCR) were noted once every week during admission of all the COVID-19 positive patients.Data were analyzed using IBM-SPSS version 23. Repeated measure ANOVA using a generalized linear model was done to check the trend of values during the duration of their stay. Pearson Correlation analysis and regression models were estimated to check the relationship of MPV and P-LCR with C- reactive protein, serum Ferritin, LDH, and pro-BNP. P-values less than 0.05 were considered statistically significant.
Results: The mean age of the studied group was 55.47 (SD=±15.0) years with the female to male ratio being 2:1. Mean platelet volume showed a statistically significant positive correlation with the established set of inflammatory markers other than pro-BNP with a p-value of less than 0.05.P-LCR however showed a positive correlation with CRP (p-value of less than 0.05) only with no significant correlation with other biochemical markers.
Conclusion: MPV is reported on routine complete blood count report (CBC). It is readily available at even the most under-resourced health centers; therefore reporting the platelet indices does not require extra testing, sampling, or reagent cost. A statistically significant positive correlation amongst the established acute inflammatory markers and relatively understudied platelet indices (MPV) in COVID-19 provides a cost-effective, readily available, and time-efficient tool for marking disease progression.
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Glumińska-Pawlic, Jadwiga. "BEPS 13: CBCR – Country-by-Country Reporting." Studia Iuridica Lublinensia 27, no. 2 (September 17, 2018): 23. http://dx.doi.org/10.17951/sil.2018.27.2.23.
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Mahmood, A., J. Shah, and A. Majumdar. "Governance concerns in CBCT interpretation and reporting." British Dental Journal 226, no. 7 (April 2019): 470. http://dx.doi.org/10.1038/s41415-019-0164-3.
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Harrigan, Amye M., Shelley MacDonald, Bruce N. Crooks, Sarah Dyack, and Amy M. Trottier. "A Case Series of TERC Variant telomere Biology Disorders in Unrelated Families from Eastern Canada." Blood 136, Supplement 1 (November 5, 2020): 11. http://dx.doi.org/10.1182/blood-2020-143187.
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TERC variant telomere biology disorders are a rare and heterogenous group of disorders that arise from germline variants in TERC, a gene that encodes for the RNA component of telomerase. Variants in TERC lead to accelerated telomere attrition and can manifest as a wide array of clinical phenotypes affecting multiple organ systems. In this case series, we aim to add to the literature describing TERC variant telomere biology disorders by reporting cases from two unrelated families from Eastern Canada, one of whom was found to have a novel germline TERC variant and the other had a unique phenotypic presentation of previously described TERC variant. The proband of family A presented intrapartum at the age of 19 with moderate thrombocytopenia but was otherwise healthy. Her past medical history was significant for premature greying of hair as a teenager. The patient went on to have a bone marrow biopsy post-partum, as the thrombocytopenia was persistent. The bone marrow biopsy revealed a diagnosis of myelodysplastic syndrome (MDS). When she was 30 years of age, proband A's father was subsequently diagnosed with MDS. He was 53 years of age at the time of his diagnosis and he passed away of his disease 1 year later. Proband A has not required any treatment for her MDS as her blood counts have remained stable, and she now has three children. Given the family history, the proband of family A and her three children were referred to adult and pediatric hematology, respectively and medical genetics. The two youngest children, an 11-year-old male and a 9-year-old female, were found to have leukopenia and thrombocytopenia, respectively. On next generation sequencing, the proband and the two youngest children were found to have a TERC n.107 G>T (NR_001566.1) variant. The eldest child, who's CBC was normal, was not a carrier. This variant has been previously reported in the literature however it has not been reported with MDS as the phenotype. The findings in this family support allelic segregation of this variant with disease, which changes the classification of the variant from "likely pathogenic" to "pathogenic" according to the American College of Medical Genetics and Genomics/Association for Molecular Pathology classification of sequence variants. The proband of family B is a male who presented to his primary care provider at the age of 35 with symptoms of generalized fatigue and was found to have macrocytic anemia and thrombocytopenia on his complete blood count. His past medical history was significant for premature greying of hair, diabetes mellitus type 2, obesity and smoking. He underwent a bone marrow biopsy that revealed a diagnosis of aplastic anemia. One year later, he was also diagnosed with pulmonary fibrosis. This diagnosis was made based on a CT scan that was done because of proband B's strong maternal family history of pulmonary fibrosis affecting his mother, maternal uncle and grandfather. Proband B was referred to hematology and medical genetics for further testing. Next generation sequencing revealed a TERC n.437 T>G (NR_001566.1) variant. Unfortunately, there was no tissue available for testing from the other affected family members as they had passed away from complications related to pulmonary fibrosis. This is the first report of this TERC variant in the literature. Reporting novel presentation of known TERC variants and/or novel TERC variants is important to help clinicians recognize and diagnose telomere biology disorders as this has important implications for the management of patients, their families, and future generations. Disclosures No relevant conflicts of interest to declare.
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Harvey, Simon, and Shanon Patel. "Guidelines and template for reporting on CBCT scans." British Dental Journal 228, no. 1 (January 2020): 15–18. http://dx.doi.org/10.1038/s41415-019-1115-8.
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Calu, Daniela Artemisa, and Mirela Nichita. "Non-Financial Reporting and Reporting for Management in the Circumstances of the Coronavirus Crisis." CECCAR Business Review 1, no. 6 (June 30, 2020): 13–20. http://dx.doi.org/10.37945/cbr.2020.06.02.
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Tonelli, Michele, Elena Cichero, Alì Mokhtar Mahmoud, Alessandro Rabbito, Bruno Tasso, Paola Fossa, and Alessia Ligresti. "Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction." MedChemComm 9, no. 12 (2018): 2045–54. http://dx.doi.org/10.1039/c8md00461g.
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Herein we continued our previous work on the development of CB2 ligands, reporting the design and synthesis of a series of benzimidazole-containing derivatives that were explored as selective CB2 ligands.
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Sugar, Elizabeth, Adam J. Pascoe, and Nilofer Azad. "Reporting of preclinical tumor-graft cancer therapeutic studies." Cancer Biology & Therapy 13, no. 13 (August 16, 2012): 1262–68. http://dx.doi.org/10.4161/cbt.21782.
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Bujaki, Merridee L. "Cost-benefit analysis in correspondence related to building the Rideau Canal." Accounting History 15, no. 2 (May 2010): 229–51. http://dx.doi.org/10.1177/1032373210352373.
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The relationship between government and the military is examined through the use of cost-benefit analysis (CBA) statements included in correspondence related to building the Rideau Canal. Discourse analysis is used to identify and evaluate CBA statements. CBA statements are used for rhetorical, technical and reporting purposes. Rhetorical uses of CBA predominate in the period leading up to the construction of the Rideau Canal. CBA as a tool for decision-making of a technical nature is common during the construction of the canal. CBA serves both rhetorical and technical purposes in progress reports. Patterns in the use of CBA in correspondence between government and military are also analysed and reveal a number of communication channels where communication using CBA statements between government and the military is either common or is lacking.
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Dzaye, Omar, Ramzi Dudum, Mohammadhassan Mirbolouk, Olusola A. Orimoloye, Albert D. Osei, Zeina A. Dardari, Daniel S. Berman, et al. "Validation of the Coronary Artery Calcium Data and Reporting System (CAC-DRS): Dual importance of CAC score and CAC distribution from the Coronary Artery Calcium (CAC) consortium." Journal of Cardiovascular Computed Tomography 14, no. 1 (January 2020): 12–17. http://dx.doi.org/10.1016/j.jcct.2019.03.011.
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Ram, Angeline, John O’Connell, Marina Efthymiou, and Eric Tchouamou Njoya. "HOW SAFE IS SAFE? A CANADIAN AIR CARRIERS (CAC) SAFETY BEHAVIOR INVESTIGATION." Journal of Air Transport Studies 10, no. 2 (July 1, 2019): 1–31. http://dx.doi.org/10.38008/jats.v10i2.141.
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The importance of safety within an organization is determined by the implementation of a Safety Management System (SMS), organizational culture, management commitment and behaviour, the activity of staff themselves, and to what degree safety reporting is upheld (Cohen, Wiegmann and Shappell, 2015). Canada was the first country globally to implement regulation mandating a Safety Management System (SMS) program. Many Canadian air carriers (CAC) proudly announce safety as a top priority, which is achieved through their SMS program. Amidst aviation’s verbal safety saturation, safety is often communicated as the top priority within the industry; however, are the public declarations consistent with CAC practices? This paper investigates whether safety behaviour within CAC is aligned to the objectives of the SMS. In-depth interviews with seven senior safety experts were conducted to identify areas of improvement and a survey with 164 respondents. This research found that there are many areas of improvement of the safety performance of CAC. Factors, which affect safety reporting behaviour and the priority of safety, include management’s support of a safety culture, job function, and the number of air carriers an individual has worked for. This research also suggests that a job function that was created to instil public confidence is more likely to deviate from safety procedures and less likely to report. A template for safety success, which influences organizational culture resulting in economic viability output, is proposed and recommendations for safety culture enforcement by the regulators.
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NICHITA, Mirela, and Daniela Artemisa CALU. "Financial Reporting for Entities Applying IFRS, in the Context of the Coronavirus Crisis." CECCAR Business Review 2020, no. 5 (May 30, 2020): 13–23. http://dx.doi.org/10.37945/cbr.2020.05.02.
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Bunget, Ovidiu-Constantin, Alin-Constantin Dumitrescu, Cristian Lungu, and Andrei-Marius Olariu. "Opinions Regarding the Impact of the COVID-19 Pandemic over the Financial Reporting." CECCAR Business Review 1, no. 7 (July 31, 2020): 11–18. http://dx.doi.org/10.37945/cbr.2020.07.02.
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Fu, Yuan, Hong-Yu Lin, Somsinee Wisitpitthaya, William A. Blessing, and Yimon Aye. "A Fluorimetric Readout Reporting the Kinetics of Nucleotide-Induced Human Ribonucleotide Reductase Oligomerization." ChemBioChem 15, no. 17 (September 24, 2014): 2598–604. http://dx.doi.org/10.1002/cbic.201402368.
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Shammo, Jamile M., Agne Paner, MV Ramana Reddy, Rachel L. Mitchell, and Parameswaran Venugopal. "A Striking Reduction of Monoclonal Protein in a Patient with Concurrent Plasma Cell Dyscrasia and CMML-2, after Treatment with Rigosertib (01910.Na)." Blood 126, no. 23 (December 3, 2015): 5362. http://dx.doi.org/10.1182/blood.v126.23.5362.5362.
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Abstract Rigosertib (ON 01910.Na) is a member of a broader class of unsaturated sulfone kinase inhibitors capable of inducing profound mitotic spindle abnormalities, abnormal centrosome localization, G2-M cell cycle phase arrest and mitotic catastrophe, culminating in apoptosis. Rigosertib is a Ras mimetic that interferes with phosphoinositide 3-kinase (PI-3K)/Akt, reactive oxygen species and Ras/Raf/polo-like kinase (PLK) signaling pathways. Although broadly cytotoxic against malignant cells, it is remarkably non-toxic for non-neoplastic cells. For this reason, this is a particularly attractive compound to test against neoplastic diseases of the bone marrow such as MDS and acute leukemia. This is a report of an unexpected reduction in monoclonal IgG, during a subject participation in a Phase III, randomized study of rigosertib, in patients with MDS who have either failed to respond, or progressed after receiving hypomethylating agents (ONTIME Trial). A 75-year-old man with CMML-2 had a CBC on day 1 of the trial that demonstrated leukocytosis, with absolute monocytosis, 7% blasts in the peripheral blood, Hgb of 9.4 gm/dl, and platelets of 7 K. He was transfusion dependent for both pRBCs and platelets. His chemistry panel demonstrated a high total protein of 9.9 (NL: 6.0 - 8.2 G/DL) with low albumin at 2.4 (NL: 3.5 - 5.0 G/DL); therefore, an SPEP/IPEP was performed, reporting the presence of monoclonal IgG kappa. Quantitative immunoglobulins showed an elevated IgG of 3594 mg/dl (NL: 596 - 1584 MG/DL). Serum free light chains were remarkable for an elevated Kappa fraction at 38.94 (NL: 0.33 - 1.94 MG/DL). On day 1 of cycle 5 of rigosertib, he was started on pulse decadron for 2 months, after which his disease progressed to AML, and he died shortly thereafter. Neither his bone marrow biopsies, nor his hematological parameters demonstrated a response to treatment with rigosertib. In contrast and interestingly, his total protein, serum kappa light chain load, and total IgG, all were drastically reduced shortly after initiation of rigosertib, as can be seen in the graph below depicting a substantial drop in his kappa light chain as well as the kappa/light chain ratio. Importantly, reduction in the monoclonal protein was noted prior to initiation of pulse decadron. Even though his initial bone marrow biopsy did not note a monoclonal plasma cell population, a subsequent bone marrow reported a low-level involvement with a plasma cell dyscrasia, with kappa light chain restriction. His final bone marrow biopsy confirmed progression to AML, but the previously seen plasma cell dyscrasia was no longer present. Conclusion: We are not aware of prior reports describing a similar effect of rigosertib on M-proteins. However, in vitro studies with rigosertib have demonstrated antitumor effects and induction of apoptosis in myeloma cell lines1. This observation merits further exploration of this agent in multiple myeloma. References: 1. Reddy MV, et al. Discovery of a Clinical Stage Multi-Kinase Inhibitor Sodium (E)-2-{2-Methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON01910.Na): Synthesis, Structure-Activity Relationship, and Biological Activity. J Med Chem, 2011, 54(18):6254-76. Figure 1. Decrease in serum free kappa light chains following initiation of rigosertib. Figure 1. Decrease in serum free kappa light chains following initiation of rigosertib. Figure 2. Decrease in kappa/lambda ratio following initiation of rigosertib. Figure 2. Decrease in kappa/lambda ratio following initiation of rigosertib. Disclosures Shammo: Onconova: Research Funding.
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Dunleavy, Michael P., Avirup Guha, Andrea Cardona, Christopher Fortuna, Emile G. Daoud, Subha V. Raman, and Thura T. Harfi. "Prevalence of Coronary Artery Calcification on Pre-Atrial Fibrillation Ablation CT Pulmonary Venograms and its Impact on Selection for Statin Therapy." Journal of Clinical Medicine 9, no. 6 (May 28, 2020): 1631. http://dx.doi.org/10.3390/jcm9061631.
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Atherosclerotic cardiovascular disease (ASCVD) shares many risk factors with atrial fibrillation (AF). Obtaining computed tomography images of the pulmonary veins (CTPV) before AF ablation procedures is common and can incidentally detect coronary artery calcification (CAC). The purpose of this study was to investigate the prevalence of CAC on pre-ablation CTPV, the frequency of CAC reporting on CTPV reports, and its impact on statin therapy among patients hospitalized for AF procedures. We retrospectively evaluated consecutive patients undergoing CTPV and AF procedures from October 2016 to December 2017 in a single-center tertiary hospital. The patients’ demographic and clinical characteristics were analyzed. The CAC presence on CTPV was visually assessed. The severity was classified qualitatively. The statin therapy status was evaluated using the patient’s admission and discharge medication lists. A total of 638 subjects were included in our study, with 34.5% female. The mean age was 63.3 ± 10.8 years. CAC was detected in 70.1% of all patients, and in 58.1% of patients without a history of ASCVD. When present, CAC was documented in 92.6% of the clinical CTPV reports. While coronary artery atherosclerosis was present in a majority of AF patients, and its presence was widely reported, it was not associated with increased statin therapy at discharge.
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BÂTCĂ-DUMITRU, Corina-Graziella, and Alina-Mihaela IRIMESCU. "Financial Reporting According to National Accounting Regulations, in the Context of the Coronavirus Crisis." CECCAR Business Review 2020, no. 5 (May 30, 2020): 3–12. http://dx.doi.org/10.37945/cbr.2020.05.01.
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Păunescu, Mirela, Adriana Florina Popa, and Radu Ciobanu. "Specific Cases Regarding the Income Tax – The Reporting of Tax Losses and Tax Redemptions." CECCAR Business Review 2, no. 3 (March 31, 2021): 15–23. http://dx.doi.org/10.37945/cbr.2021.03.02.
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Kühn, Anna-Lena, Markus Stiglbauer, and Janina Heel. "Does mandatory CSR reporting lead to higher CSR transparency? The case of France." Corporate Ownership and Control 11, no. 2 (2014): 29–45. http://dx.doi.org/10.22495/cocv11i2p3.
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Expedited by the financial crisis and increased stakeholder activism, the demand for reliable and accountable business practices and transparency has gained momentum in the current corporate social responsibility (CSR) debate. Consequently, companies have started to become aware of the increasing importance of conveying increased transparency and accountability to stakeholders, gaining their legitimacy and establishing a positive public image through adequate CSR reporting. Since it is obligatory to disclose information on corporate financial performance and on companies’ environmental and social impact in France, this paper addresses how transparent French listed companies of the CAC 40 communicate their CSR engagement externally. To turn the latent construct ‘transparency of CSR reporting’ into a measurable value, we conduct qualitative content analysis based on the Global Reporting Initiative (GRI) guidelines. Assuming mandatory CSR reporting to increase companies’ CSR transparency in general, most of the companies communicate their corporate profile, strategy and management broadly. Whereas companies report the environmental dimension most frequently, they refer only marginally to the economic and social dimensions.
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TIRON-TUDOR, Adriana, Teodora Viorica FĂRCAȘ, Ioana DRAGU, and Ecaterina Monica MOISE. "Non-Financial Reporting in Romania in the pre-Directive 2014/95/EU Period (1990-2013)." CECCAR Business Review 2020, no. 5 (May 30, 2020): 63–72. http://dx.doi.org/10.37945/cbr.2020.05.07.
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Cappabianca, Salvatore, Maria Paola Belfiore, Alfonso Reginelli, Raffaella Capasso, Alessandra Del Prete, Mario Petrillo, Paola Mascia, et al. "Mandatory Reporting of Coronary Artery Calcifications Incidentally Noted on Chest Multi-Detector Computed Tomography: A Multicentre Experience." Current Vascular Pharmacology 17, no. 1 (November 16, 2018): 92–98. http://dx.doi.org/10.2174/1570161116666180117111856.
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Background: Coronary Artery Calcifications (CACs) are associated with coronary atherosclerosis and Cardiovascular (CV) events. In “non-cardiovascular” settings, CACs can be easily detected on chest Multi-Detector Computed Tomography (MDCT). Their evaluation may help to better stratify CV risk in the general population, especially for primary prevention. </P><P> Aims: We retrospectively evaluated the relationship between CAC distribution and CV risk, determined by Framingham Risk Score (FRS), in a cohort of patients who underwent chest MDCT performed for several clinical indications. </P><P> Method: We retrospectively recruited 305 patients (194 men, 111 women; mean age 70.5 years) from 3 different Italian centres. Patients with coronary stent, pacemaker and/or CV devices were excluded from the study. Circumflex Artery (LCX), Left Main Coronary Artery (LMCA), left Anterior Descending artery (LAD) and right coronary artery (RCA) were analysed. </P><P> Results: From a total population of 305 patients, 119 (39%) had low FRS (<10%), 115 (38%) had intermediate FRS (10-20%), and 71 (23%) had high FRS (>20%). The study identified 842 CACs located in decreasing order as follows: RCA (34.5%), LAD (32.3%), LCX (28%) and LMCA (13%). Statistical two-step analysis subdivided patients into two clusters according to FRS (risk threshold = 12.38%): cluster I (mean 9.34) and cluster II (mean 15.09). A significant association between CAC distribution and cluster II was demonstrated. CACs were mostly detected in patients with intermediate FRS. All patients (100%) with the highest CV risk showed intermediate RCA and LMCA involvement. </P><P> Conclusion: Radiologists can note the distribution of CACs on a chest MDCT and should mandatorily record them in their reports. Depending on CAC presence and location, these findings may have important clinical implications, mostly in asymptomatic patients with intermediate FRS. This information may reclassify a patients’ CV risk and improve clinical management.
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Brattwall, M., M. Warrén Stomberg, N. Rawal, M. Segerdahl, E. Houltz, and J. Jakobsson. "Patient assessed health profile: A six-month quality of life questionnaire survey after day surgery." Scandinavian Journal of Public Health 38, no. 6 (June 11, 2010): 574–79. http://dx.doi.org/10.1177/1403494810374221.
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Aim: Patient assessed quality of life is one of the principal end-points after day surgery. The aim of the present study was to describe the natural course, differences and timing of final evaluation for three common day surgical procedures; inguinal hernia repair (IHR), arthroscopic procedures (AS); and cosmetic breast augmentation (CBA). Method: A total of 355 patients prospectively completed an extended eight-item EQ-5D questionnaire (pain, mobility, mood, self-care, activities, sleep, sex, need for analgesic), preoperatively and at one, three and six months postoperatively. Results: Pain and mobility problems were frequently reported prior to surgery among IHR and AS patients, while CBA patients had less deviation from normal in the preoperative health profile. The proportions of patients reporting surgery-related deviations were 35%, 20% and 5% at one, three and six months respectively. After one month, 50% of AS patients still suffered subjective discomfort as compared to 13% and 20% of the IHR and CBA patients, respectively. Pain and ambulation problems were the most common symptoms in all groups. Six months after surgery, 94% of IHR, 89% of AS and 97% of CBA patients were fully recovered. Conclusions: No major morbidity or severe complications were observed and patients’ satisfaction was high overall. We found procedure-specific changes in the postoperative health profile after day surgery. AS patients recovered more slowly compared with IHR and CBA patients. We conclude that time for final evaluation differs significantly between procedures.
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Pirinen, Teija, Kaija-Leena Kolho, Merja Ashorn, and Eeva T. Aronen. "Sleep and Emotional and Behavioral Symptoms in Adolescents with Inflammatory Bowel Disease." Sleep Disorders 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/379450.
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The current study assessed the associations between sleep and psychosocial symptoms in 157 Finnish adolescents with inflammatory bowel disease (IBD). Sleep trouble was self-rated in Sleep Self-Report (SSR) and in Youth Self-Report (YSR). Psychosocial symptoms of the adolescents were assessed by the YSR and Child Behavior Checklist (CBCL). Patients reporting sleep trouble had significantly more psychosocial symptoms than their counterparts without sleep trouble. This was shown in the CBCL and YSR scales of total problems (P<0.01), anxious/depressed mood (P<0.05), and aggressive behavior (P<0.01). Additionally, SSR sleep problem subscale scores indicating lower sleep quality (bedtime, sleep behavior) associated significantly with attention problems (P<0.05). These results point out that sleep trouble should be recognized and treated in adolescents with IBD to possibly avoid the emerging of psychosocial symptoms.
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Tiron-Tudor, Adriana, Teodora Viorica Fărcaş, Ioana Dragu, and Ecaterina Monica Moise. "The Road to Transposing the Non-Financial Reporting EU Directive within the Romanian Context – The 2013-2020 Period." CECCAR Business Review 1, no. 6 (June 30, 2020): 63–72. http://dx.doi.org/10.37945/cbr.2020.06.08.
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Mooberry, Micah J., Robert Bradford, Robin Kellerman, Eric Sobolewski, Harry C. Stafford, Robert G. McMurray, Eric D. Ryan, and Nigel S. Key. "An Exploratory Study of the Effects of Strenuous Exercise On Markers of Activation of Coagulation, Inflammation and Endothelial Activation: Possible Implications for Exercise-Related Morbidity in Sickle Cell Trait." Blood 120, no. 21 (November 16, 2012): 3224. http://dx.doi.org/10.1182/blood.v120.21.3224.3224.
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Abstract Abstract 3224 The acute physiological response to strenuous exercise is characterized by a transient hypercoagulable state as well as an acute inflammatory response. Despite these well-recognized findings, the mechanisms involved in these exercise-induced effects are not well understood. To further evaluate the effect of exercise on multiple hematologic parameters, subjects underwent an exercise protocol with blood samples obtained at several time points. Fifteen healthy male African-American subjects [10 normal hemoglobin (HbAA), 5 sickle cell trait (HbAS)], ages 18–35, exercised at 65% of VO2max × 30 min followed by an increase in treadmill grade of 2.5% every 3 min until volitional exhaustion. Blood was collected at baseline, immediately post-exercise, and at 1 and 2 hours post-exercise. Analyses included CBC, D-dimer, sVCAM, LDH, haptoglobin, plasma free hemoglobin (PF Hb), RBC phosphatidylserine (PS) exposure (by flow cytometry), microparticle (MP) procoagulant activity (Zymuphen MP-activity assay measuring ‘PS equivalents’), and MP-tissue factor (MP-TF) activity (in-house chromogenic assay). Flow cytometric enumeration of MPs in platelet poor plasma was performed using a standardized ISTH protocol, and included platelet MP (PMP: AnnV+/CD41+), endothelial MP (EMP: CD31+/CD41−), red cell MP (RBC MP: AnnV+/CD235a+), leukocyte MP (LMP: AnnV+/CD45+), and monocyte MP (MMP: AnnV+/CD14+) analyses. As previously reported, increases in total WBC count, monocyte count, and sVCAM occurred immediately after exercise, with return towards baseline thereafter. A similar transient increase was seen with both MP procoagulant activity and MP-TF activity (Fig. 1), with a 2.5- (p<0.01) and 3-fold (p<0.01) increase, respectively. Acute increases were also observed for PMPs, EMPs, LMPs and MMPs, which peaked immediately post-exercise. No significant changes were noted for D-dimer, Hb, LDH, or haptoglobin; however, a modest increase in PF Hb was noted following exercise. Interestingly, some unique differences were seen in HbAS compared to HbAA subjects; specifically, EMPs peaked later (at 2 hrs) and were more elevated in HbAS subjects, although the difference was not statistically significant (HbAS 138.2 +/−162.3 EMPs/uL vs. HbAA 65.4 +/− 29.3 EMPs/uL; p=0.26). Additionally, there was a trend towards increased RBC MPs in HbAS subjects (HbAS: 291 +/− 284 RBC MPs/uL at baseline vs. 975 +/− 1033 RBC MPs/uL at 2 hrs; p=0.13). A trend towards increased RBC PS exposure immediately post-exercise in HbAS subjects compared to HbAA was also apparent (Fig. 2), with almost 3× more RBC PS exposure in the HbAS group (post exercise % PS+ RBCs: HbAS 1.28 +/− 1.05% vs. HbAA 0.22 +/− 0.10%; p=0.09, n=4). We also observed a trend towards lower haptoglobin and increased D-dimer in HbAS subjects compared to HbAA subjects at all time points. These data confirm previous observations reporting systemic activation of coagulation occurring after strenuous exercise, and demonstrate a transient increase in MP-TF activity. Interestingly, the time course and magnitude of this activity differs from that seen in the human endotoxemia model (data not shown), in which there is a 5–7 fold increase in MP-TF activity that peaks much later (4 hours) post LPS exposure. The much earlier peak and lower magnitude (∼ 3-fold increase) with exercise suggest a mechanism that does not involve cellular synthesis of TF but is instead likely due to a release of pre-formed TF stores. Other findings in this study may also be relevant to the pathophysiology of the well-documented risk of exertional sudden death with sickle cell trait. In particular, we speculate that the increased RBC PS exposure, elevated RBC MPs and a relative increase in EMPs may contribute to increased activation of coagulation and occlusion of the microvasculature during exercise that may result in DIC, rhabdomyolysis and sudden death. Disclosures: No relevant conflicts of interest to declare.
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Caruso, Silvia, Ennio Storti, Alessandro Nota, Shideh Ehsani, and Roberto Gatto. "Temporomandibular Joint Anatomy Assessed by CBCT Images." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2916953.
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Aim. Since cone beam computed tomography (CBCT) has been used for the study of craniofacial morphology, the attention of orthodontists has also focused on the mandibular condyle. The purpose of this brief review is to summarize the recent 3D CBCT images of mandibular condyle. Material and Methods. The eligibility criteria for the studies are (a) studies aimed at evaluating the anatomy of the temporomandibular joint; (b) studies performed with CBCT images; (c) studies on human subjects; (d) studies that were not clinical case-reports and clinical series; (e) studies reporting data on children, adolescents, or young adults (data from individuals with age ≤ 30 years). Sources included PubMed from June 2008 to June 2016. Results. 43 full-text articles were initially screened for eligibility. 13 full-text articles were assessed for eligibility. 11 articles were finally included in qualitative synthesis. The main topics treated in the studies are the volume and surface of the mandibular condyle, the bone changes on cortical surface, the facial asymmetry, and the optimum position of the condyle in the glenoid fossa. Conclusion. Additional studies will be necessary in the future, constructed with longitudinal methodology, especially in growing subjects. The limits of CBCT acquisitions are also highlighted.
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Gendarme, Sébastien, Helene Goussault, Jean-Baptiste Assié, Cherifa Taleb, Christos Chouaïd, and Thierry Landre. "Impact on All-Cause and Cardiovascular Mortality Rates of Coronary Artery Calcifications Detected during Organized, Low-Dose, Computed-Tomography Screening for Lung Cancer: Systematic Literature Review and Meta-Analysis." Cancers 13, no. 7 (March 28, 2021): 1553. http://dx.doi.org/10.3390/cancers13071553.
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Although organized, low-dose, computed-tomography (CT) scan lung-cancer screening has been shown to lower all-cause and lung-cancer-specific mortality, the primary cause of death for subjects eligible for such screening remains cardiovascular (CV) mortality. This meta-analysis study was undertaken to evaluate the impact of screening-scan-detected coronary artery calcifications (CACs) on CV and all-cause mortality. We conducted a systematic review and meta-analysis of studies reporting CV mortality according to the Agatson CAC score for participants in a lung-cancer screening program of randomized clinical or cohort studies. PubMed, Embase, and Cochrane databases were screened in June 2020. Two authors independently selected articles and extracted data. Six studies, including 20,175 subjects, were retained. CV and all-cause mortality rates were higher for subjects with CAC scores >0, with respective relative risks of 2.02 [95% CI 1.23–3.32] and 2.29 [95% CI 1.00–5.21]. Both mortality rates were even higher for those with high CAC scores (>400 or >1000). CACs are more common in men than in women, with an odds ratio of 1.49 [95% CI 1.40–1.59]. The presence of CAC is associated with CV mortality with an RR of 2.05 [95% CI 1.20–3.57] in men and 2.37 [CI 95% 1.29–5.09] in women, respectively. Analysis of lung-cancer-screening scans for CACs is a tool able to predict CV mortality. Prospective studies within those programs are needed to assess the benefit of primary CV prevention based on CAC detection.
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Amado, Pedro, Fábio Albuquerque, and Nuno Rodrigues. "Los factores explicativos de la divulgación por segmentos en entidades no financieras cotizadas en los mercados europeos." Contaduría y Administración 63, no. 2 (April 10, 2018): 36. http://dx.doi.org/10.22201/fca.24488410e.2018.1629.
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<p><span lang="EN-US">Segment reporting (external) is a relevant tool for investors and other stakeholders, as the information is presented in a divisional way, enabling more accurate analysis to be made for decision making. However, reporting entities do not always assure the inherent potential of segment reporting. This research aims to identify the explanatory factors that may influence the level of segment disclosure. For this purpose, we have investigated the segment disclosures presented in accordance with the International Financial Reporting Standards (IFRS) 8 of the International Accounting Standards Board (IASB), as adopted by the European Union, based on consolidated reports and accounts (for the year 2015) of a sample of 91 entities from the Portuguese Stock Index (PSI-20), <em>Cotation Assistée en Continu </em>(CAC-40), <em>Deutscher Aktienindex </em>(DAX-30) and OMX Nordic 40 (OMX-N40). The findings indicate that size is directly related to both the number of operating segments disclosed and the level of disclosure required for each segment. Further, the latter seems to be also influenced by the existence of barriers to entry (directly) and the degree of internationalisation (inversely).</span></p>
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Sporer, Siegfried L., Antonio L. Manzanero, and Jaume Masip. "Optimizing CBCA and RM research: recommendations for analyzing and reporting data on content cues to deception." Psychology, Crime & Law 27, no. 1 (May 5, 2020): 1–39. http://dx.doi.org/10.1080/1068316x.2020.1757097.
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Craciunescu, Oana, Taoran Li, Zhang Chang, Beverly Steffey, Sheridan Meltsner, and Junzo Chino. "Role of Pre Treatment CBCT in Dose Reporting for MRI-Based Planning of Cervical Cancer Patients." Brachytherapy 14 (May 2015): S74. http://dx.doi.org/10.1016/j.brachy.2015.02.323.
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Nikolaev, A. E., A. N. Shapiev, I. A. Blokhin, D. M. Ramazanova, A. N. Shapieva, V. A. Gombolevskij, and L. A. Nizovtsova. "New approaches for assessing coronary changes in multi-layer spiral computed tomography." Russian Journal of Cardiology, no. 12 (December 28, 2019): 124–30. http://dx.doi.org/10.15829/1560-4071-2019-12-124-130.
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The article presents an overview of qualitative and quantitative methods for coronary calcification assessment by computed tomography (CT). Coronary calcium is one of the well-known predictors of coronary artery disease and its complications. Coronary artery calcification is a common significant finding on routine and low-dose CT. In the review, the Coronary Artery Calcium Data and Reporting System (CAC-DRS) and the Coronary Artery Disease Reporting and Data System (CAD-RADS) are analyzed. Recommendations are given for the further management of patients with stable or acute chest pain in accordance with the CAD-RADS classification. The main aim of CAD-RADS is the standardization of accounting for coronary computed tomography angiography (CCTA) results for facilitating the interpretation by clinicians and subsequent management of patients. Such an approach should lead to an increase of healthcare quality.
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Saremi, Adonis, and Rohit Arora. "Therapeutic Implications of Coronary Artery Calcium Using Cardiac Computed Tomography." Clinical medicine. Cardiology 1 (January 2007): CMC.S330. http://dx.doi.org/10.4137/cmc.s330.
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The objective of this document is to review the clinical applicability of coronary artery calcium (CAC) scoring in both asymptomatic and symptomatic patients at risk for cardiovascular disease. We begin by describing the pathological basis of atherosclerosis, the characteristic stages of atherosclerotic plaque development, and the mechanism and role of arterial calcification in advanced atherosclerotic lesions. We also explain the utility of CAC scoring in cardiovascular risk assessment, discuss the most current clinical methods for measuring CAC, and examine major clinical studies reporting CAC scores in both asymptomatic and symptomatic heart patients. Lastly, the current recommendations for CAC scoring as stated by the American College of Cardiology/American Heart Association (ACC/AHA) are outlined, and a number of considerations for future research are provided. Atherosclerosis begins when certain factors cause chronic endothelial injury, which eventually leads to the build up of fibrofatty plaques in the intima of arterial blood vessels. In time, blood vessel walls can weaken, thrombi can form and plaques can send emboli to distal sites. There are six characteristic stages of plaque development. Mature plaques may be calcified in an active process comparable to bone remodeling, where calcium phosphate crystals coalesce among lipid particles inside arterial walls. Calcification is only present in atherosclerotic arteries, and the site and levels of calcium are non-linearly and positively associated with luminal narrowing of coronary vessels. Calcification is also postulated to stabilize vulnerable plaques in atherosclerotic vessels. Recent studies have shown that CAC scoring can improve the management of both asymptomatic and symptomatic heart patients. Electron beam computed tomography (EBCT) and Multidetector computed tomography (MDCT) are two fast cardiac CT methods used to measure CAC. No matter what technique one uses, CAC is scored with either the Agatston or the “volume” score system. The ACC/ AHA currently finds it is reasonable for asymptomatic patients with intermediate Framingham risk scores (FRS) to undergo CAC assessment because these patients can be re-stratified into the high risk category if their CAC scores are ≥400. Conversely, CAC measurement in asymptomatic patients with low or high FRS is not warranted. There is also no evidence to suggest that high risk asymptomatic patients with no detectable coronary calcium should not be treated with secondary prevention medical therapy. For symptomatic patients, the ACC/AHA recommends CAC assessment as a second line technique to diagnose obstructive CAD, or when primary testing modalities are not possible or are unclear. Furthermore, they do not recommend the use of CAC measurement to determine the etiology of cardiomyopathy, to help identify patients with acute MI in the emergency room, or to assess the progression or regression of coronary atherosclerosis. Future research needs to incorporate calcium scores with percentile rankings, larger population samples, more women with at least intermediate Framingham risk, sufficient numbers of non-Caucasians, reports on cost-effectiveness, and data on populations with Chronic Kidney Disease, End Stage Renal Disease and Diabetes.