Relevant bibliographies by topics / CB₂

Academic literature on the topic 'CB₂'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "CB₂"

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Lougen, Colleen. "CB Insights." Journal of Business & Finance Librarianship 22, no. 3-4 (October 2, 2017): 247–50. http://dx.doi.org/10.1080/08963568.2017.1372018.

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Moreno, Francisco, Guillermo Orrego, and Andrés Pineda. "CB-SMoT+: Una Extensión al Algoritmo CB-SMoT." Lámpsakos 1, no. 8 (December 15, 2012): 9. http://dx.doi.org/10.21501/21454086.673.

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Una trayectoria es un registro de la evolución de la posición de un objeto móvil. Por ejemplo, un vehículo que se mueve en el espacio durante un intervalo de tiempo. Una trayectoria se representa mediante una secuencia de observaciones que indican la posición y el tiempo en el que fue tomada cada observación. CB-SMoT es un algoritmo que identifica las partes de una trayectoria durante las cuales el objeto mantuvo una velocidad promedio por debajo de un límite dado. En este artículo se propone una extensión para dicho algoritmo que permite identificar las partes de una trayectoria durante las cuales el objeto mantuvo una velocidad promedio entre observaciones por debajo de un límite dado. Esto posibilita la identificación, por ejemplo, de violaciones a un límite de velocidad que no son advertidas por el algoritmo original. Para el estudio se usó el sistema de gestión de bases de datos PostgreSQL y los algoritmos se implementaron en su lenguaje de programación, llamado PL/pgSQL. Además, se hicieron experimentos con 100 trayectorias de vehículos con el propósito de mostrar la utilidad y la viabilidad de la propuesta
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Woods, D. L., R. K. Gugel, and K. C. Falk. "CB 9940 and CB 9941 summer turnip rapes." Canadian Journal of Plant Science 81, no. 3 (July 1, 2001): 461–63. http://dx.doi.org/10.4141/p00-124.

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Two canola-quality summer turnip rape (Brassica rapa L.) lines that are resistant to blackleg [Leptosphaeria maculans (Desm.) Ces. et de Not.] have been developed. Glucosinolates are marginally higher, while seed yields and oil contents are lower than the check cultivars. Key words: Rape, canola, Brassica rapa, germplasm description, blackleg resistance
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Luxenburg, Joan, and Lloyd Klein. "CB Radio Prostitution." Journal of Offender Counseling Services Rehabilitation 9, no. 1-2 (February 27, 1985): 71–87. http://dx.doi.org/10.1300/j264v09n01_05.

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Yan, Peng-Fei, and Li-Hong Xie. "Monotone cb-spaces." Topology and its Applications 156, no. 15 (September 2009): 2537–44. http://dx.doi.org/10.1016/j.topol.2009.07.011.

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Workman, Paul, Richard A. S. White, and Kathleen Talbot. "CB 1954 revisited." Cancer Chemotherapy and Pharmacology 16, no. 1 (January 1986): 1–8. http://dx.doi.org/10.1007/bf00255278.

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Workman, Paul, Jane E. Morgan, Kathleen Talbot, Karen A. Wright, Jane Donaldson, and Peter R. Twentyman. "CB 1954 revisited." Cancer Chemotherapy and Pharmacology 16, no. 1 (January 1986): 9–14. http://dx.doi.org/10.1007/bf00255279.

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Bakovets, V. V., E. A. Kovalenko, T. P. Chusova, L. N. Zelenina, and P. E. Plyusnin. "State of water in CB[6] and CB[8] cavitands." Russian Chemical Bulletin 62, no. 10 (October 2013): 2109–15. http://dx.doi.org/10.1007/s11172-013-0309-5.

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Russell, W. A., and W. D. Guthrie. "Registration of BS17(CB)C4 and BS16(CB)C4 Maize Germplasm." Crop Science 31, no. 1 (January 1991): 238–39. http://dx.doi.org/10.2135/cropsci1991.0011183x003100010071x.

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Liu, Simin, Kimoon Kim, and Lyle Isaacs. "Mechanism of the Conversion of Inverted CB[6] to CB[6]." Journal of Organic Chemistry 72, no. 18 (August 2007): 6840–47. http://dx.doi.org/10.1021/jo071034t.

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Dissertations / Theses on the topic "CB₂"

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Köhler, Martin. "Cb-LIKE." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-185151.

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Gewitterzellen mit ihren negativen Begleiterscheinungen wie Starkregen, Hagel oder Fallwinden verursachen Verspätungen sowie Flugausfälle und sind damit für höhere Kosten der Airlines und Flughafenbetreiber verantwortlich. Eine verlässliche Vorhersage von Gewittern bis zu mehreren Stunden könnte dagegen den Entscheidungsträgern am Flughafen einen größeren zeitlichen Spielraum geben, um auf mögliche Gewitterzellen angemessen zu reagieren und adäquate Maßnahmen zu ergreifen. Zur Bereitstellung zuverlässiger Gewittervorhersagen bis zu sechs Stunden wurde Cb-LIKE am Deutschen Zentrum für Luft- und Raumfahrt (DLR) entwickelt. Der neue Gewittervorhersagealgorithmus wird in der vorliegenden Dissertation detailliert vorgestellt. Cb-LIKE ist ein automatisiertes System, das unter Verwendung von Modelldaten des COSMO-DE Wettermodells des Deutschen Wetterdienstes (DWD) Gebiete ausweist, die eher für oder gegen eine Entwicklung von Gewittern sprechen. Vier atmosphärische Parameter (CAPE, Vertikalwind, Radarreflektivität und Temperatur an der Wolkenobergrenze) fließen in das System ein. Eine neu entwickelte „Best-Member-Selection“ sorgt dabei durch einen Abgleich zur aktuellen Gewittersituation für die automatische Auswahl des realistischsten Modelllaufes aus einem Ensemble. Dadurch wird die beste Datengrundlage für die Berechnung der Gewittervorhersagen gewährleistet. Für die Auswahl des besten Members stehen vier verschiedene Modi zur Verfügung. Ein neu entwickeltes Fuzzy-Logik System ermöglicht anschließend die Kombination der Modelldaten und die Berechnung eines Gewitterindikators von 11,6¯6 bis 88,3¯3 für jeden Gitterpunkt des Modells für die nächsten sechs Stunden in stündlichen Intervallen. Je höher der Wert des Indikators, desto mehr sprechen die Modellparameter für die Entstehung von Gewittern. Zusätzlich wird die Vorhersagequalität des neuen Algorithmus anhand einer umfassenden Verifikation unter Verwendung einer „neighbourhood-verification“ Technik und von „multi-event contingency tables“ untersucht. Für die Sommerperiode 2012 weist Cb-LIKE im Vergleich zur COSMO-DE Radarreflektivität bessere Werte in den Verifikationsgrößen auf. So ist das „Fehlalarmverhältnis“ für den neuen Algorithmus niedriger (0,48 zu 0,56), die „Wahrscheinlichkeit der Detektion“ (0,52 zu 0,45) und der „Critical Success Index“ (0,50 zu 0,48) fallen dagegen höher aus. Die Resultate zeigen, dass der Cb- LIKE Algorithmus eine sinnvolle neue Methodik für Gewittervorhersagen von hoher Qualität auf der Datenbasis des COSMO-DE Modells darstellt. Die Ergebnisse aus der Verifikation ermöglichen außerdem die Übersetzung des Cb-LIKE Indikatorfeldes in die gewünschten probabilistischen Gewittervorhersagen. Zusätzlich wird die erfolgreiche Implementierung der Cb-LIKE Gewittervorhersagen in das WxFUSION System, eine graphische Benutzeroberfläche, vorgestellt.
Thunderstorm cells with their adverse weather hazards like heavy rain, hail or downbursts cause delays and flight cancellations at airports and, as a negative result, the airlines and airport operators have to bear high additional cost. A reliable thunderstorm forecast up to several hours could provide more time for the decision makers at the airport for an appropriate reaction on possible storm cells and initiation of adequate counteractions. To provide the required thunderstorm forecasts up to six hours Cb-LIKE has been developed at the DLR (Deutsches Zentrum für Luft- und Raumfahrt) Institute of Atmospheric Physics. The development of the new algorithm is described in detail in the present dissertation. Cb-LIKE is an automated system which designates areas with possible thunderstorm development by using model data of the COSMO-DE numerical weather prediction model, which is driven by the German Meteorological Service (DWD). Four atmospheric parameters (CAPE, vertical wind velocity, radar reflectivity and cloud top temperature) of the model output are used within the system. A newly developed “Best-Member-Selection“ allows the automatic selection of that model run of a COSMO-DE model ensemble which matches best the observed storm situation. Thereby, the application of the best available data basis for the calculation of the thunderstorm forecasts is ensured. Altogether there are four different modes for the selection of the best member. A newly developed fuzzy logic system enables the subsequent combination of the model data and the calculation of a thunderstorm indicator within a value range of 11. ¯ 66 up to 88. ¯ 33 for each grid point of the model domain for the following six hours in hourly intervals. The higher the indicator the more the model parameters imply the development of thunderstorms. The forecasting quality of the new algorithm is demonstrated by a thorough verification using a neighborhood verification approach and multi-event contingency tables. For the summer period of 2012 Cb-LIKE shows better results in the verification scores in comparison to the COSMO-DE radar reflectivity. For example the new algorithm features a lower „False Alarm Ratio“ (0,48 to 0,56) and a higher „Probability of Detection“ (0,52 to 0,45) and „Critical Success Index“ (0,50 to 0,48). The results show that Cb-LIKE is a sensible novel approach to obtain probabilistic thunderstorm forecasts of high quality on the data basis of the COSMO-DE model. Finally, the implementation of the Cb-LIKE forecasts into the WxFUSION system which is a graphical user interface is presented.
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Schreier, Martin. "The value increment of mass-customized products: An empirical assessment." Wiley-Blackwell, 2006. http://dx.doi.org/10.1002/cb.183.

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The primary argument in favor of mass customization is the delivery of superior customer value. Using willingness-to-pay (WTP) measurements, Franke & Piller (2004) have recently shown that customers designing their own watches with design toolkits are willing to pay premiums of more than 100% (DWTP). In the course of three studies, we found that this type of value increment is not a singular occurrence but might rather be a general phenomenon, as we again found average DWTPs of more than 100% among customers designing their own cell phone covers, T-shirts, and scarves. Building on this, we discuss the sources of benefits that are likely to explain this tremendous value increment. We argue that compared to conventional standard products, a mass-customized product might render the following utilitarian and hedonic benefits: (1) First, the output might be beneficial as self-designed products offer a much closer fit between individual needs and product characteristics. In addition to this mere functional benefit, extra value might also stem from (2) the perceived uniqueness of the self-designed product. As the customer takes on the role of an active codesigner, there may also be two general 'do-it-yourself effects': (3) First, the process of designing per se is likely to allow the customer to meet hedonic or experiential needs (process benefit). (4) Customers may also be likely to value the output of self-design more highly if they take pride in having created something on their own (instead of traditionally buying something created by somebody else). This is referred to as the 'pride of authorship' effect. (author's abstract)
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Ruzeviciute, Ruta, and Bernadette Kamleitner. "Attracting new customers to loyalty programs: The effectiveness of monetary versus non-monetary loyalty programs." John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/cb.1663.

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What type of reward attracts customers to loyalty programs? Given the increasing importance of loyalty programs, this question matters. Six sequential studies investigated whether monetary rewards universally attract people more than nonmonetary rewards. Results suggest that monetary rewards elicit a very robust attractiveness premium both on the level of individual rewards as well as on the level of entire reward programs. Across different industries, the more monetary loyalty program was consistently perceived as more attractive, and it was more likely to inspire intentions to join the program. Even in light of variations in consumption goals (hedonic vs. utilitarian), the effect persisted. The effect is not only consistent; it is also nonnegligible with medium effect sizes emerging in most settings. We discuss ensuing variations in effect sizes and conclude that monetarism holds a pervasive temptation for consumers that managers cannot ignore.
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Bayer, Michael J. "Neue Carborane aus CB 2 -, CB 3 - und C 2 B 2 -Organoboranen." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9837041.

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Somani, Hanif. "Novel analogues of CB 1954." Thesis, Institute of Cancer Research (University Of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338418.

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Přech, Zdeněk. "Posouzení finančního zdraví společnosti CB Auto, a.s." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-264297.

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The diploma thesis evaluates the financial health of the company CB Auto a.s., by using the methods of financial analysis. The purpose of the study is to evaluate the financial health with regard to the expansion of the portfolio of the company to open a new department OJETÉ VOZY Das Welt Auto Škoda Plus v Českých Budějovicích in 2013. The financial analysis is applied to period from 2010 to 2014. The thesis is divided into two parts, theoretical and application part. The basic terms from the financial analysis field are summarized in the theoretical part. This part also describes particular methods. These methods are applied in application part. Based on the results of this analysis the overall financial health is evaluated. Then there is introduced the proposal for improving the situation of the company in future.
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Kiill, Noélle Egídia Watanabe. "Efeito da inibição dos receptores canabinóides CB₁ ou CB₂ durante o período neonatal sobre o dimorfismo sexual esquelético ao longo do desenvolvimento /." Araçatuba, 2015. http://hdl.handle.net/11449/134199.

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Orientador: João Cesar Bedran de Castro
Coorientador: José Antunes Rodrigues
Banca: Roberta Okamoto
Banca: Keico Okino Nonaka
Resumo: O objetivo do presente estudo foi caracterizar o impacto da breve bloqueio dos receptores canabinóides CB1 ou CB2 durante o período neonatal sobre o crescimento somático e desenvolvimento esquelético durante a infância, puberdade e na idade adulta em ratos. Ratos Wistar recém-nascidos foram distribuídos aleatoriamente em seis grupos, três grupos do sexo masculino e três grupos femininos. Os grupos tratados receberam durante os primeiros sete dias de vida de uma dose subcutânea de antagonistas dos receptores CB1 (AM251) ou CB₂ (SR144528) (3 mg/kg dissolvidos em 50 uL de veículo composto em álcool absoluto e tampão fosfato salino - PBS). Os grupos controle receberam a solução veículo com mesmo volume e período. O peso corporal foi mensurado aos 20, 40, 120 dias de idade e os fêmures direitos foram coletados. O comprimento e a espessura dos fêmures foram medidos e a densidade mineral óssea areal (DMO areal) foi determinada por meio de um densitômetro de dupla emissão de raios-X (DEXA). O teste biomecânico de flexão da cabeça do fêmur foi utilizado para avaliar a força máxima, a energia para fratura, e rigidez extrínseca dos ossos. Ganho de massa corporal, DMO areal e propriedades biomecânicas do osso aumentaram rapidamente com a idade em todos os grupos. Entre animais veículo, os padrões de dimorfismo sexual esquelética foram evidentes após a puberdade. No entanto, o bloqueio neonatal dos receptores canabinóides CB1 e CB2 promoveu um efeito transitório e sexo-dependentes sobre a massa corporal e desenvolvimento ósseo ao longo da vida, e que a inibição neonatal desses receptores nos machos promoveu um efeito bifásico sobre a aquisição de DMO areal ao longo do desenvolvimento, e aumento da fragilidade óssea nos machos AM251 na idade adulta. Este estudo demonstrou que...
Abstract: The aim of the present study was to characterize the impact of brief blockade of cannabinoid CB1 or CB2 receptors during neonatal period on somatic growth and skeletal development during childhood, puberty, and adulthood in rats. Newborn Wistar rats were randomly divided into six groups, three male groups and three female groups. The treated groups received during the firsts seven days of life a subcutaneous dose of a CB1 (AM251) or CB₂ (SR144528) receptors antagonist (3 mg/kg dissolved in 50 μl of a vehicle consisting of absolute ethanol and phosphate buffered saline - PBS). Control groups received the vehicle solution in the same volume and period. Body weight was measured at 20, 40, 120 days of age and femurs were collected. The length and thickness of the femurs were measured and the areal bone mineral density (areal BMD) was determined by dual-energy X-ray absorptiometry (DEXA). Biomechanical femoral neck bending testing was used to evaluate bone breaking strength, energy to fracture, and extrinsic stiffness. Weight gain, areal BMD and bone biomechanical properties increased rapidly with respect to age in all groups. In vehicle animals, skeletal sexual dimorphism patterns were evident after puberty. However, neonatal blockade of cannabinoid CB1 and CB2 receptors promoted a transient and sex-dependent effect on the body weight and bone development throughout the life, and that neonatal inhibiting the CB1 and CB2 receptors in males promotes a biphasic effect on the acquisition of areal BMD throughout development, and increased bone fragility in males AM251 in adulthood. This study demonstrated that brief blockade of cannabinoid CB1 or CB2 receptors during neonatal period causes a long-lasting and sex-dependents modification in somatic growth and skeletal development in rats
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Kiill, Noélle Egídia Watanabe [UNESP]. "Efeito da inibição dos receptores canabinóides CB₁ ou CB₂ durante o período neonatal sobre o dimorfismo sexual esquelético ao longo do desenvolvimento." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/134199.

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O objetivo do presente estudo foi caracterizar o impacto da breve bloqueio dos receptores canabinóides CB1 ou CB2 durante o período neonatal sobre o crescimento somático e desenvolvimento esquelético durante a infância, puberdade e na idade adulta em ratos. Ratos Wistar recém-nascidos foram distribuídos aleatoriamente em seis grupos, três grupos do sexo masculino e três grupos femininos. Os grupos tratados receberam durante os primeiros sete dias de vida de uma dose subcutânea de antagonistas dos receptores CB1 (AM251) ou CB₂ (SR144528) (3 mg/kg dissolvidos em 50 uL de veículo composto em álcool absoluto e tampão fosfato salino - PBS). Os grupos controle receberam a solução veículo com mesmo volume e período. O peso corporal foi mensurado aos 20, 40, 120 dias de idade e os fêmures direitos foram coletados. O comprimento e a espessura dos fêmures foram medidos e a densidade mineral óssea areal (DMO areal) foi determinada por meio de um densitômetro de dupla emissão de raios-X (DEXA). O teste biomecânico de flexão da cabeça do fêmur foi utilizado para avaliar a força máxima, a energia para fratura, e rigidez extrínseca dos ossos. Ganho de massa corporal, DMO areal e propriedades biomecânicas do osso aumentaram rapidamente com a idade em todos os grupos. Entre animais veículo, os padrões de dimorfismo sexual esquelética foram evidentes após a puberdade. No entanto, o bloqueio neonatal dos receptores canabinóides CB1 e CB2 promoveu um efeito transitório e sexo-dependentes sobre a massa corporal e desenvolvimento ósseo ao longo da vida, e que a inibição neonatal desses receptores nos machos promoveu um efeito bifásico sobre a aquisição de DMO areal ao longo do desenvolvimento, e aumento da fragilidade óssea nos machos AM251 na idade adulta. Este estudo demonstrou que...
The aim of the present study was to characterize the impact of brief blockade of cannabinoid CB1 or CB2 receptors during neonatal period on somatic growth and skeletal development during childhood, puberty, and adulthood in rats. Newborn Wistar rats were randomly divided into six groups, three male groups and three female groups. The treated groups received during the firsts seven days of life a subcutaneous dose of a CB1 (AM251) or CB₂ (SR144528) receptors antagonist (3 mg/kg dissolved in 50 μl of a vehicle consisting of absolute ethanol and phosphate buffered saline - PBS). Control groups received the vehicle solution in the same volume and period. Body weight was measured at 20, 40, 120 days of age and femurs were collected. The length and thickness of the femurs were measured and the areal bone mineral density (areal BMD) was determined by dual-energy X-ray absorptiometry (DEXA). Biomechanical femoral neck bending testing was used to evaluate bone breaking strength, energy to fracture, and extrinsic stiffness. Weight gain, areal BMD and bone biomechanical properties increased rapidly with respect to age in all groups. In vehicle animals, skeletal sexual dimorphism patterns were evident after puberty. However, neonatal blockade of cannabinoid CB1 and CB2 receptors promoted a transient and sex-dependent effect on the body weight and bone development throughout the life, and that neonatal inhibiting the CB1 and CB2 receptors in males promotes a biphasic effect on the acquisition of areal BMD throughout development, and increased bone fragility in males AM251 in adulthood. This study demonstrated that brief blockade of cannabinoid CB1 or CB2 receptors during neonatal period causes a long-lasting and sex-dependents modification in somatic growth and skeletal development in rats
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Layouni, Khaled. "Comportement et fatigue multiaxiale d'un élastomère chargé (NR-CB)." Paris, ENMP, 2004. http://www.theses.fr/2004ENMP1242.

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Cette étude contribue à une compréhension assez fine du comportement du matériau, caoutchouc naturel renforcé avec du noir de carbone (NR-CB). Des sollicitations, monotones et cycliques, uniaxiales et multiaxiales, ont permis de dégager les principaux phénomènes physiques ainsi que leur influence sur le comportement de l’élastomère. Ensuite, nous avons modélisé le comportement du matériau par deux lois : la première est hyperélastique incompressible et la seconde est compressible endommageable. Enfin, une comparaison entre ces deux modèles a été effectuée. Par ailleurs, l’étude expérimentale de la fatigue sous chargements complexes a permis de décrire les interactions entre les sollicitations axiales et de torsion ainsi que l’effet du déphasage sur la localisation et la durée de vie. Cette analyse est complétée par des études fractographiques permettant l’identification des différentes phases de fissuration (échelle macroscopique) et des sites d’amorçage (échelle microscopique). Enfin, nous avons établi un critère de prévision de la durée de vie robuste sous chargements complexes. Ce critère prévoit la localisation de l’amorçage, l’orientation de fissures et le nombre de cycles à l’amorçage. Il a été validé sur des éprouvettes de structure et sur des pièces industrielles. Enfin, nous avons comparé ce critère à un modèle pris dans la littérature
This work explores the mechanical behaviour of a carbon-black reinforced natural rubber (NR-CB) subjected to monotonic, cyclic, uniaxial and multiaxial loading. Several physical phenomena have been identified. In particular, we have characterised the material compressibility under various kinds of loading conditions and confirmed the results by means of microscopic observations. Consequently, in order to describe the material behaviour, we have considered and compared two constitutive models: the first one is hyperelastic incompressible whereas the second one is more realistic as it uses a damage-induced compressible approach. Furthermore, fatigue experimental results obtained under complex loading histories allow to describe the interaction between axial and torsional loading. In particular, the phase angle effect on the lifetime and the crack location have been determined. These analyses were supported by fractographic observations that allow the identification of different tearing steps (macroscopic scale) and initiation sites (microscopic scale). Finally, we have established a model able to predict the location and orientation of cracks, as well as lifetime under complex loading. This criterion has been validated for complex geometry and industrial components. Finally, we have compared this model with another taken in literature
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Ghosh, Sumana. "CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1486.

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Endocannabinoid (eCB) system is composed of endogenous CB ligands including anandamide (AEA) and 2-Arachidonyl glycerol (2-AG), enzymes involved in their biosynthesis and degradation such as diacylglycerol lipase-α (DAGL- α), and CB receptors. Primarily, there are three types of CB receptors - CB receptor 1(CB1), CB receptor 2 (CB2) and non CB1 non CB2 types of CB receptor (e.g. GPR, TRPV1) and they belong to G-protein (Gi/o) coupled receptors (GPCR) family.CB1 receptors are abundant in the brain where they modulate neuronal activities. On the other hand, CB2 receptors are predominantly expressed in the immune cells and regulate the growth and proliferation of different immune cells and modulate the activities of cytokines network and anti-oxidant machinery in stress conditions. Inflammation plays a central role in hearing loss (HL) caused by different ototoxic insults including anti-neoplastic agents such as cisplatin, aminoglycosides and acoustic trauma. These insults can trigger chronic production of reactive oxygen species (ROS) in regions of cochlea such as organ of Corti, stria vascularis (SVA), spiral ligament (SL) and spiral ganglion neurons (SG). This leads to increased synthesis of pro-inflammatory cytokines, disruption of mitochondrial membrane integrity, activation of DNA damage/repair pathways and activation of pro-apoptotic enzymes. Jeong et al. (2007) have shown that CB2 receptor specific agonist (JWH-015) protects the HEI-OC1 hair cell cultures against cisplatin-induced cytotoxicity in-vitro. The goal of the current study was to examine the distribution and function of CB receptors (mainly CB2) in the cochlea and determine whether activation of these receptors could protect the cochlea by altering the expression of ROS generating proteins, along with pro-inflammatory and pro-apoptotic proteins. This study also investigated whether inhibition of eCB synthesis can causes HL. Aim 1 of the current study investigated the expression of CB receptors in the cochlea using different in-vivo models such as male Wistar rat and knock-in mice with GFP-tagged CB2 receptors, in-vitro models such as organotypic culture of neonatal mouse (C57BL/6) cochlea and University of Bristol organ of Corti (UB/OC1) cells. We show that both CB1 and CB2 receptors are expressed in the outer and the inner hair cells (OHCs and IHCs), SV, SG and supporting cells (SCs) included outer and inner pillar cells. The distribution of DAGL- α was also examined in the male Wistar rats and we found the similar distribution pattern of this enzymes as CB2. DAGL- α catalyzes the hydrolysis of DAG to synthesize 2-AG, which acts as a chief endogenous CB2 ligand. Our initial studies suggested a role of CB2 and not CB1 in protection, leading us to focus on CB2 receptors for subsequent studies. Aim 2 examined the otoprotective role of trans-tympanic application of CB2 specific agonist (JWH-015) against cisplatin-induced hearing loss in male Wistar rats. Activation of CB2 receptors restored cisplatin-induced elevations in ABR thresholds which was significantly reversed by CB2 antagonist AM-630. Pre-treatment with JWH-015 protected against cisplatin-induced loss of hair cell and synaptic ribbons. In-vitro studies in UB/OC-1 cells demonstrated that pre-treatment of JWH-015 modulates the activities of signal transducer and activator of transcription 1 and 3 (STAT1 and STAT3), increases the expression of anti-apoptotic protein Bcl-xL, indicating its role in regulating the apoptosis Activation of CB2 also abrogated cisplatin-induced decrease in Na+/K+ATPase- α in the SV and SL fibrocytes and ameliorated the expression of different pro-inflammatory genes including TRPV1, COX2, NOX3, KIM1, iNOS and TNF- α. We also found that blocking of CB2 by AM630 itself resulted in hearing loss and loss in CB2 receptors, indicating eCB system is tonically active and could be important for physiological function of the cochlea. Indeed, we observed that inhibition of DAGL- α by RHC80267 results in HL. Aim 3 of this current study investigated whether pre-treatment of CB2 agonist will interfere with anti-cancer efficacy of cisplatin against various cancer cell lines head and neck cancer cells (UMSCC10B), and colon cancer cells (HCT116). Our data indicate that JWH-015 did not interfere with cisplatin-induced apoptosis in these cells. Overall, this study provides novel insights into the essential role eCBs plays in protection the cochlea under non-stressed conditions and following exposure to ototoxic agents. It also demonstrates that application of exogenous CB2 agonist (JWH-015) could serve as an effective protective agent against cisplatin ototoxicity These data suggest that localized delivery of CB2 agonists should be studied in human for protection against hearing loss.
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Books on the topic "CB₂"

1

G, Harris Eric, ed. CB. 2nd ed. Mason, OH: South-Western Cengage Learning, 2011.

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Murray, Kyle B. (Kyle Bayne), 1973- author and Harris Eric G. author, eds. CB. Toronto, Ontario: Nelson Education, 2014.

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Michalina, Jerzy. CB i radiokomunikacja. Olsztyn: Wydaw. BOGMAR, 1994.

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Gordon, John. CB radio. Portsmouth: Radio Active Publications, 1996.

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Mjeda, Luka. CB Zagreb. Zagreb: S.L.M., 2002.

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G, Harris Eric, ed. CB 2008-2009. Mason, OH: Cengage Learning South-Western, 2009.

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Darlington, Mansur. Honda CB 250 T, CB 400 T and CB 400 A twins owners workshop manual. Sparkford: Haynes, 1990.

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Kneitel, Tom. Tomcat's big CB handbook. Commack, N.Y: CRB Research Books, 1988.

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Didion, James J. Tradition and vision: CB Commercial looks toward the new century. New York: Newcomen Society of the United States, 1991.

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Cb. Cengage Learning, 2021.

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Book chapters on the topic "CB₂"

1

Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, Sarah Parylak, Micaela Morelli, Nicola Simola, Nicola Simola, et al. "CB-154." In Encyclopedia of Psychopharmacology, 276. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4111.

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Kröger, Detlef, and Claas Hanken. "CB-infobank I." In Casebook Internetrecht, 357–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-19011-7_52.

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Kröger, Detlef, and Claas Hanken. "CB-infobank II." In Casebook Internetrecht, 372–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-19011-7_53.

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Hair, Joseph F., G. Tomas M. Hult, Christian M. Ringle, Marko Sarstedt, Nicholas P. Danks, and Soumya Ray. "An Introduction to Structural Equation Modeling." In Classroom Companion: Business, 1–29. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80519-7_1.

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AbstractStructural equation modeling is a multivariate data analysis method for analyzing complex relationships among constructs and indicators. To estimate structural equation models, researchers generally draw on two methods: covariance-based SEM (CB-SEM) and partial least squares SEM (PLS-SEM). Whereas CB-SEM is primarily used to confirm theories, PLS represents a causal–predictive approach to SEM that emphasizes prediction in estimating models, whose structures are designed to provide causal explanations. PLS-SEM is also useful for confirming measurement models. This chapter offers a concise overview of PLS-SEM’s key characteristics and discusses the main differences compared to CB-SEM. The chapter also describes considerations when using PLS-SEM and highlights situations that favor its use compared to CB-SEM.
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Benölken, Heinz, and Wilhelm Krutzki. "Anforderungen an das CB-Instrumentarium." In Consulting Banking, 121–28. Wiesbaden: Gabler Verlag, 1998. http://dx.doi.org/10.1007/978-3-663-05955-4_5.

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Gao, Rui Han, and Zhu Tao. "CB[n]-Based Coordination Chemistry." In Handbook of Macrocyclic Supramolecular Assembly, 695–730. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2686-2_31.

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Gao, Rui Han, and Zhu Tao. "CB[n]-Based Coordination Chemistry." In Handbook of Macrocyclic Supramolecular Assembly, 1–36. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1744-6_31-1.

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Niedereichholz, Christel, and Anja Winkelmann. "CB als Basis für Firmenkunden-Marketing." In Consulting Banking, 237–66. Wiesbaden: Gabler Verlag, 1998. http://dx.doi.org/10.1007/978-3-663-05955-4_10.

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Benölken, Heinz, and Wilhelm Krutzki. "Der Nutzen des CB (Zusammenfassende Übersicht)." In Consulting Banking, 279–83. Wiesbaden: Gabler Verlag, 1998. http://dx.doi.org/10.1007/978-3-663-05955-4_12.

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Ross, Robert B. "Niobium Nb (also called columbium, Cb)." In Metallic Materials Specification Handbook, 264–65. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3482-2_29.

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Conference papers on the topic "CB₂"

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Calvi, Marta. "Determination of $V_{cb}$." In 8th International Symposium on Heavy Flavour Physics. Trieste, Italy: Sissa Medialab, 1999. http://dx.doi.org/10.22323/1.003.0033.

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Nandi, Soumitra. "Improvements to inclusive $V_{cb}$." In 9th International Workshop on the CKM Unitarity Triangle. Trieste, Italy: Sissa Medialab, 2017. http://dx.doi.org/10.22323/1.291.0048.

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Gong, Shengjie, and Kwang Mong Sim. "CB-Cloudle and cloud crawlers." In 2014 5th IEEE International Conference on Software Engineering and Service Science (ICSESS). IEEE, 2014. http://dx.doi.org/10.1109/icsess.2014.6933503.

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Watanabe, Ryotaro. "$|V_{cb}|$ and New Physics." In 11th International Workshop on the CKM Unitarity Triangle. Trieste, Italy: Sissa Medialab, 2023. http://dx.doi.org/10.22323/1.411.0060.

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Lee, Sunghun, Myeongwon Lee, Jin Park, and Hongjip Kim. "A Numerical Study on Flow Characteristics of Super Sonic Diffuser for the Position and Nose Cone Angles of Center Body." In ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/ajkfluids2019-5430.

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Abstract The center body diffuser is one of supersonic diffuser that can simulate high-altitude environment. There is center-body structure inside the diffuser, and a complex fluid flow is occurred inside the diffuser because of the interaction of the CB structure with gas exhausted from the nozzle outlet. In this study, starting point and flow characteristics of diffuser were investigated according to changing the CB nose cone angle and the length of distance between nozzle and CB structure. The differences of the supersonic flow were compared through each parameter of CB distance and CB nose angle. First changed parameter was length between nozzle and CB. According to the length of distance between nozzle and CB, axial momentum was developed and oblique shock wave moved front of CB from end of CB nose cone. Also, when CB position was located on a certain length, starting point of CBD decreased. Next change parameter was angle of CB nose cone. According to the angle raised, angle of oblique shock wave was raised and radial momentum of supersonic diffuser developed. But, according to radial momentum of supersonic flow over certain angle, the starting pressure of CBD increased. Because axial momentum which isolated vacuum chamber from atmospheric pressure. Through these CFD analysis results, it was shown that angle and length of distance between nozzle and CB influent performance of CBD.
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Oliveira, Osmair Vital de, Isabella Barros de Oliveira, Felipe Edilino de Lima, and Rafael Giordano Viegas. "Encapsulation of the vitamins D3 and E in cucurbit[7]uril: A computational investigation." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol202066.

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In this work, molecular dynamics simulation (MD) was used to study the encapsulation of fat-soluble vitamins D3 (vD3) and E (a-TOC) into cucubit[7]uril (CB[7]) in an aqueous solution. Cucurbiturils is a class of macrocyclic molecules largely used as carrier and controlled release agent in order to improve the solubility and chemoprotective of drugs. Along 50 ns of MD trajectory, the vitamins formed a stable complex with CB[7] without significantly altering its structure. Moreover, the second solvation shell of the CB[7] was not disrupted by the inclusion of the vitamins. The solvation enthalpy was ~ –173.0 kcal/mol for both complexes and –177.6 kcal/mol for the isolated CB[7], suggesting that the vitamin@CB[7] complexes are soluble in water. The binding free energy indicates that CB[7] can act as carrier agent for these vitamins, with values of –17.54 and –23.76 kcal/mol for vD3@CB[7] and a-TOC@CB[7], respectively. Finally, herein we highlight that CB[7] can be a new host to be used for vitamin delivery in biological systems.
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Lall, Ravinder P. "Chemical biological (CB) defense, technology, solution, for tactical CB threat detection by active/passive CB electromagnetic (EM) radiation (photons), 8-12μM wavelength and electro-optics." In Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing X. SPIE, 2009. http://dx.doi.org/10.1117/12.818888.

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Sain, Arghya, and Kathleen L. Melde. "Surface roughness modeling for CB-CPWs." In 2012 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting. IEEE, 2012. http://dx.doi.org/10.1109/aps.2012.6348793.

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Kogan, Dan. "Design and implementation of CB Lite." In the conference. New York, New York, USA: ACM Press, 1993. http://dx.doi.org/10.1145/168555.168568.

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A. V., Nomoev, Romanov N. A., Kalashnikov S. V., and Tsyrenova M. A. "Liquid Crystals 5 CB Doped Nanoparticles." In NANOMATERIALS AND TECHNOLOGIES-VI. Buryat State University Publishing Department, 2016. http://dx.doi.org/10.18101/978-5-9793-0883-8-22-26.

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Reports on the topic "CB₂"

1

Winegar-Johnson, Anna. Responding to the CB Threat Past- Present- Future. Fort Belvoir, VA: Defense Technical Information Center, July 2001. http://dx.doi.org/10.21236/ada386130.

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Morii, M. Determination of |V{sub cb}| and Results from BABAR. Office of Scientific and Technical Information (OSTI), June 2004. http://dx.doi.org/10.2172/827008.

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Thomas, M. C. Next Generation LWIR Spectrum Projector (CB-2) Design Study. Fort Belvoir, VA: Defense Technical Information Center, June 2004. http://dx.doi.org/10.21236/ada424508.

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Millage, Kyle K., Gene E. McClellan, Bahman Asgharian, Joshua J. Bergman, Darren R. Oldson, and Sharon A. Watson. Medical Modeling of Particle Size Effects for CB Inhalation Hazards. Fort Belvoir, VA: Defense Technical Information Center, September 2015. http://dx.doi.org/10.21236/ada621672.

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Yam, Aleksander, and Alex Vainer. Creation of Vapor/Gas Impermeable Coatings for CB Hardening of Existing Structures. Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada584952.

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BATTELLE MEMORIAL INST BEL AIR MD. Wide Area Decontamination: CB Decontamination Technologies, Equipment and Projects - Literature Search and Market Survey. Fort Belvoir, VA: Defense Technical Information Center, March 1999. http://dx.doi.org/10.21236/ada403026.

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Myrick, Michael L. University of South Carolina CB Support, Basic Research in Materials and Techniques for Optical Computing Standoff Sensors. Fort Belvoir, VA: Defense Technical Information Center, October 2004. http://dx.doi.org/10.21236/ada429819.

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Marti-Arbona, Ricardo. Scientist on the Flight Line Event DTRA CB and US Air Force Air Combat Command 823rd Red Horse Squadron. Office of Scientific and Technical Information (OSTI), July 2018. http://dx.doi.org/10.2172/1459625.

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Della Ricca, Giuseppe. Measurement of |V{sub cb}| using {bar B}{sup 0} {yields} D*{sup +}{ell}{sup -}{bar {nu}}{sub {ell}} Decays. Office of Scientific and Technical Information (OSTI), August 2003. http://dx.doi.org/10.2172/815252.

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Aubert, B. Measurement of the {bar B}{sup 0} --> D*{sup +} {ell}{sup -} {bar {nu}}{sub {ell}} Decay Rate and |V{sub cb}|. Office of Scientific and Technical Information (OSTI), August 2004. http://dx.doi.org/10.2172/829739.

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