Journal articles on the topic 'Cavenagh'

Abstract Background : While myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are considered sporadic hematopoietic stem cell clonal disorders, there are rare occurrences of familial cases (<5%) where two or more individuals within the same family are affected. These high-risk examples are characterised by wide variations in the age of onset, disease latency and outcome between and within families, making their investigation, follow-up and treatment all the more challenging.To date, germline mutations in 11 disease genes have been described, with mutations in the myeloid transcription factor GATA2 representing one of the best-characterised genetic loci predisposing to inherited hematological malignancies. We have noted that within GATA2 families, particularly those segregating a germline p.Thr354Met mutation, there is striking evidence of reduced penetrance. In our example, two first-degree cousins (III.1 and III.3) developed high-risk MDS with monosomy 7 with a third cousin (III.7) presenting with significant leukopenia (monocytopenia [0.1x109/L] and neutropenia [0.8x109/L]). This contrasts with the parental generation (II.1, II.3 and II.5) who all remain hematologically normal and symptom free into their mid-late 60s (Figure 1). We therefore set out to understand these differences in clinical presentation between mutation carriers. Aims:To investigate the molecular mechanisms underlying the variable penetrance and clinical heterogeneity observed in a GATA2-mutated family. Results:Targeted deep-sequencing of 33 genes frequently mutated in MDS/AML revealed a low overall burden of acquired mutations in the symptomatic carriers with no mutations detected in asymptomatic family members. It was noteworthy that an acquired ASXL1 mutation (p.Gly646TrpfsTer12) was identical in all affected individuals (III.1, III.3 and III.7) (Figure 1) although the variant allele frequency was lower (12%) in III.7 and remained stable (range 12-6%) over a 4 year monitoring period. GATA2 expression was lower in III.7 as assessed by quantitative RT-PCR and strikingly this was associated with monoallelic expression of the mutated GATA2 allele with complete loss of the wild-type (WT) allele expression. Temporal analysis of III.7 at yearly intervals demonstrated reactivation of the WT allele 2 years later, coinciding with a marked improvement in hematological parameters (normal monocyte count, neutrophils >1x109/L). These changes in GATA2 expression were not linked to gross changes in methylation, as assessed by methylation specific PCR and bisulphite sequencing, nor acquisition of additional mutations in the WT promoter. Instead, we believe that allele-specific fluctuations in expression are accompanied by changes in chromatin structure at the promoter. Using a SNP (rs1806462 [C/A]) located in the 5'UTR of GATA2, we assessed allele-specific enrichment of H3K4me3 and H3K27me3 chromatin marks by chromatin immunoprecipitation. Sanger sequencing revealed a significant enhancement in the deposition of H3K4me3 activating chromatin mark on the mutated allele compared to the WT allele at diagnosis and this was reversed at later follow-up, correlating with reactivation of the WT allele expression. There were no discernible allele-specific differences in the H3K27me3 mark across the phenotypes at different time-points. Conclusion: Variable penetrance amongst germline mutation carriers is a feature of many families with inherited forms of MDS/AML and this may be related to the nature of secondary genetic events acquired in at-risk individuals. In this study, however, we show that changes in the WT:mutant allele expression ratio as a result of local and allele-specific changes in chromatin deposition may also influence the penetrance of the inherited mutation. Figure 1 Figure 1. Disclosures Cavenagh: Amgen: Consultancy, Speakers Bureau; Novartis: Consultancy, Speakers Bureau; Janssen: Consultancy, Speakers Bureau; Celgene: Consultancy, Speakers Bureau.

Goodby My Little Ones by C. Hickey, T. Lighty, and J. O'Brien, Onyx Books, 1996. This recent book, and the three others listed below, should be read by every pediatrician who is in the apnea monitoring business! It describes in detail the confession, trial, and conviction of "Mrs H," who murdered her five children. Two of these cases were reported by Dr A. Steinschneider in 1972, and formed the basis for the hypothesis of sleep apnea as a cause of sudden infant death syndrome (SIDS) (Pediatrics, 1972). This article started the apnea monitoring "rage" that continues today. The effectiveness of this monitoring in preventing deaths remains unproven despite extensive studies. OTHER BOOKS ON THE SAME SUBJECT: Sleep My Child, Forever by John Coston Mommie's Little Angels by Mary Lou Cavenaugh Precious Victims by Don W. Weber and Charles Bosworth, Jr

Abstract Background Proteasome inhibitors (PIs) are central to anti-MM therapy and 3 are currently licensed: bortezomib, carfilzomib and ixazomib, increasing treatment options. Bortezomib (BZ) and carfilzomib (CFZ) have been studied in head-to-head comparison using a CFZ dose of 56mg/m2 in doublet with dexamethasone in relapse (ENDEAVOR), and also at 36mg/m2 in triplet with melphalan and prednisolone in newly diagnosed non-transplant eligible patients. Differing results may relate to dosing and scheduling, as well as to different study populations. There is growing evidence for triplet regimens especially at relapse. Aims The MUK five phase 2 study compared the activity and safety of CFZ and BZ in triplet combination using a CFZ dose of 36mg/m2, with cyclophosphamide and dexamethasone (KCD vs VCD), for patients at first relapse, or refractory to no more than 1 prior line of therapy. Methods The study compares 8 cycles of VCD with 6 cycles of KCD (24 weeks treatment), and also assesses the benefit of maintenance carfilzomib in the KCD arm. Participants were randomised (R1) in a 2:1 ratio in favour of KCD, minimisation factors were β2M, prior bortezomib, prior ASCT and timing of first relapse (&lt; or ≥12 months). Participants in the KCD arm with at least stable disease (SD) after 6 cycles of KCD were randomised (R2) 1:1 to receive maintenance carfilzomib or no further treatment. Participants in the VCD arm did not receive maintenance. Inclusion criteria included Hb&gt;80g/L, neutrophils&gt;1.0x109/L, platelets 50x109/L and GFR&gt;30ml/min. KCD therapy was 28 day cycles of biweekly carfilzomib 20/36mg/m2 IV (weeks 1-3) while VCD was 21 day cycles of biweekly bortezomib 1.3mg/m2 SC (weeks 1 and 2), both with cyclophosphamide 500mg orally weekly (weeks 1-3 only for KCD) and dexamethasone 40mg orally weekly. Co-primary endpoints were ≥VGPR rates at 24 weeks post R1 (powered for non-inferiority comparison, deemed non-inferior (NI) if 90% confidence interval (CI) for odds ratio (OR) &gt;0.8), and PFS from R2 (superiority). Disease response was assessed according to the Modified IWG Uniform Response Criteria, and minimal residual disease (MRD) by multiparameter flow cytometry (10-4). Results From Feb 2013 to Sept 2016, 300 participants were randomised, 201 to KCD and 99 to VCD. Patient and disease features were balanced between arms, median ages 67 and 69 years, 57.5% and 64.6% male, 93.5% and 94.9% ECOG 0-1 for KCD and VCD respectively. Median time from diagnosis was 32.5 and 36.1 months, 50.0% and 45.5% were ISS 2/3, and 66.2 and 67.7% had had an ASCT. While 81.6% of patients in the KCD arm received all 6 treatment cycles, only 53.5% in the VCD arm received all 8 cycles; reasons for stopping treatment were toxicity (KCD, 7%; VCD, 19.2%), disease progression (6.5%, 6.1%) and withdrawal of consent (2.5%, 11.1%). Dose modifications occurred in 78.6%, and 85.4% of patients in the KCD and VCD arms respectively. A total of 196 and 96 patients were evaluable for efficacy analysis in the KCD and VCD arms. Major response (≥VGPR) at 24 weeks for KCD and VCD was 40.2% and 31.9% respectively (OR 1.48; 90% CI (0.95, 2.31), deemed NI). Overall response (≥PR) was 84.0% and 68.1% (OR 2.72; 90% CI (1.62, 4.55); p=0.0014, deemed superior). MRD negativity (all evaluable patients; n=134 KCD, n=48 VCD) at 24 weeks was 16.4% for KCD and 12.5% for VCD. The safety population was 292 patients (KCD, 196; VCD 96). Treatment emergent neuropathy occurred in 21.4% and 56.3% of patients in the KCD and VCD arm, respectively. The proportion of patients with grade ≥3 neuropathy or grade ≥2 neuropathy with pain (key secondary endpoint) was lower with KCD (1.5%, vs 19.8% with VCD; p&lt;.0001). Details of serious adverse events (SAEs) are given in Table 1; these were largely comparable between the arms, except for more neurological SAEs in the VCD arm (8.1% vs 0.7%) and more cardiac SAEs in the KCD arm (4.2% vs 1.4%). Adverse reactions (ARs) were also comparable except for more grade ≥3 neutropenia and thrombocytopenia with VCD and more grade ≥3 anaemia with KCD. Conclusion Major response (≥VGPR) to KCD therapy is non-inferior to VCD and overall response rate is superior to VCD over a fixed treatment duration. This may be related to better tolerability and reduced incidence of neurotoxicity with KCD, with superiority of KCD in terms of grade ≥3 neuropathy or grade ≥2 neuropathy with pain. Further details on safety and activity will be presented at the meeting. Disclosures Yong: Janssen: Honoraria, Research Funding; Amgen: Honoraria, Research Funding. Auner: Amgen: Honoraria, Research Funding. Williams: Janssen: Honoraria, Other: travel support, Speakers Bureau; Celgene: Honoraria, Other: travel support, Speakers Bureau; Takeda: Honoraria, Other: travel support, Speakers Bureau; Amgen: Honoraria, Speakers Bureau; Novartis: Honoraria. Cavenagh: Amgen: Honoraria; Janssen: Honoraria; Celgene: Honoraria. Kaiser: Chugai: Consultancy; BMS: Consultancy, Other: Travel expenses; Takeda: Consultancy; Janssen: Honoraria; Celgene: Consultancy, Honoraria, Research Funding; Amgen: Consultancy, Honoraria. Rabin: Novartis: Consultancy, Speakers Bureau; Takeda: Consultancy, Other: Travel support for meetings, Speakers Bureau; Celgene: Speakers Bureau; Amgen: Consultancy, Speakers Bureau; Janssen: Consultancy, Other: Travel support for meetings, Speakers Bureau. Ramasamy: Janssen: Honoraria; Takeda: Honoraria, Research Funding; Amgen: Honoraria. Garg: Janssen: Other: travel support, Research Funding, Speakers Bureau; Takeda: Other: travel support; Novartis: Other: travel support, Research Funding. Hawkins: janssen: Honoraria. Morgan: Takeda: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Research Funding; Bristol Myers: Consultancy, Honoraria. Davies: Amgen: Consultancy, Honoraria; Bristol-Myers: Consultancy, Honoraria; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Consultancy, Honoraria. Owen: Celgene: Consultancy, Honoraria, Research Funding; Takeda: Honoraria, Other: travel support; Janssen: Consultancy, Other: travel support.

In recent years, there has been renewed appreciation of the morbidity which can result from unusual or overwhelming stress and while many situations can give rise to post-traumatic disorder, the most frequently studied of these is probably military combat. Psychiatric disorder pursuant to combat experience can not only become chronic, but may intensify with advancing age, decades after the original trauma (Archibald & Tuddenbaum, 1965; Wilmer, 1982). Moreover, a high percentage of combat veterans are believed ultimately to develop chronic psychiatric morbidity (Walker & Cavenar, 1982). The drug treatment of such post-traumatic states remains an important question, largely over looked until the last 2 years but recent case reports suggest that doxepin and imipramine (White, 1983; Burstein, 1984) are beneficial in treating post traumatic stress disorder (PTSD), which may be either combat or non-combat related. Hogben & Cornfield (1981) described five veterans whose PTSD improved when treated with phenelzine, while Van der Kolk (1983) has described beneficial results with antidepressants, lithium, benzodiazepines, beta blockers, and neuroleptics in uncontrolled studies of PTSD.

ABSTRACT Aim To evaluate the effectiveness of ProTaper universal retreatment system in the removal of root canal filling material with thermomechanical compaction, in comparison to manualmechanical technique, associated with orange oil or eucalyptol. Materials and methods Forty extracted lower incisors were filled with thermomechanical compaction technique. After 3 years, the root canal filling was removed by: G1 - manualmechanical technique with orange oil; G2 - manual-mechanical technique with eucalyptol; G3 - ProTaper universal retreatment system with orange oil and G4 - ProTaper universal retreatment system with eucalyptol. In sequence, all root canals were instrumented to F5 instrument. The teeth were longitudinally grooved, images of buccal half were obtained in stereomicroscope and covered area by root canal filling material was measured using image tool software, in cervical, middle and apical radicular thirds. The results were subjected ANOVA and Tukey test (p = 0.05). Results In all thirds, the manual-mechanical technique showed lower presence of root canal filling material on root canal dentin in comparison to ProTaper retreatment universal system, regardless of organic solvent used (p < 0.05). There is no difference between organic solvents in removal root canal filling material (p > 0.05). Conclusion The ProTaper universal retreatment system showed lower effectiveness in removal root canal filling material than manual-mechanical technique, regardless of organic solvents (orange oil or eucalyptol oil) used. Clinical significance Recently rotary instruments have been proposed to removal of root canal filling material. However, there are no studies evaluating its effectiveness in removal root canal filling material in association with orange oil or eucalyptol oil. How to cite this article Guiotti FA, Kuga MC, de Toledo Leonardo R, Chávez-Andrade GM, Magro MG, Cavenago BC, Faria G. Effectiveness of ProTaper Retreatment System associated with Organic Solvents in the Removal of Root Canal Filling Material. World J Dent 2013;4(3):175-179.

Pressure swing adsorption (PSA) appears to be an effective technology for biogas upgrading under different operating conditions with low greenhouse gas emissions. This study presents the simulation of biomethane adsorption with the adsorption bed filled with a carbon molecular sieve (CMS). A six dual-bed six-step PSA process was studied which produced a high purity of biomethane. The design of the adsorption bed was followed by the real process of which the biomethane capacity was more than 5000 Nm3/h. For the adsorbent, a CMS-3K was used, and a biomethane gas with a minimum 92% purity was produced at 6.5 bar adsorption pressure. To understand the adsorption characteristics of the CH4 and CO2 gases, the Langmuir isotherm model was used to determine the isotherm of a mixed gas containing 55% CH4 and 45% CO2. Furthermore, the experimental data from the work of Cavenati et al. were used to investigate the kinetic parameter and mass transfer coefficient. The mass transfer coefficients of two species were determined to be 0.0008 s−1 and 0.018 s−1 at 306 K for CH4 and CO2, respectively. The PSA process was then simulated with a cyclic steady state until the relative tolerance was 0.0005, which was then used to predict the CH4 and CO2 mole fraction along the adsorption bed length at a steady state. Moreover, the optimal conditions were analyzed using Aspen Adsorption to simulate various key operating parameters, such as flowrate, adsorption pressure and adsorption time. The results show a good agreement between the simulated results and the real operating data obtained from the company REBiofuel. Finally, the sensitivity analysis for the major parameters was presented. The optimal conditions were found to be an adsorption pressure of 6 bar, an adsorption time of 250 s and a purity of up to 97.92% with a flowrate reducing to 2000 Nm3/h. This study can serve as a commercial approach to reduce operating costs.

In 2003 Grüttmüller proved that if $n\geqslant 3$ is odd, then a partial transversal of the Cayley table of $\mathbb{Z}_n$ with length $2$ is completable to a transversal. Additionally, he conjectured that a partial transversal of the Cayley table of $\mathbb{Z}_n$ with length $k$ is completable to a transversal if and only if $n$ is odd and either $n \in \{k, k + 1\}$ or $n \geqslant 3k - 1$. Cavenagh, Hämäläinen, and Nelson (in 2009) showed the conjecture is true when $k = 3$ and $n$ is prime. In this paper, we prove Grüttmüller’s conjecture for $k = 2$ and $k = 3$ by establishing a more general result for Cayley tables of Abelian groups of odd order.

Cavanaugh Mound (3SB3, also known as Etter's Mound, Jones Mound, Site Zeta, and occasionally misspelled Cavenaugh) is a largely intact Late Prehistoric platform mound on the Arkansas River just east of the Oklahoma border, about 14 km from the Spiro Mounds complex. The site is situated on a high terrace above the Arkansas River as it runs between the Ouachita Mountains to the south and the Ozarks to the north. The Poteau River enters the Arkansas River floodplain just west of Cavanaugh, creating one of the widest stretches of bottomland in the region. The area immediately around Cavanaugh Mound is now a residential neighborhood in the city of Fort Smith, and the mound itself is in a tiny lot with a church to the south, a trailer park to the east (named Indian Mounds Trailer Park), and a row of houses to the west. At about 60 m across and 9 m high, Cavanaugh Mound is one of the largest, if not the largest, prehistoric mound in the region. Very little has been published concerning this site, however, and very little formal archeological work has been done there. This article is partly intended to call attention to Cavanaugh Mound, and to compile all reports and descriptions of the mound in one publication. The first part of the article is therefore mostly descriptive. I also offer some tentative interpretations of the site and its possible relationship to the nearby Spiro and Skidgel sites. The size , shape, and stratigraphy of the mound all indicate that it was constructed and used in a manner similar to other Caddoan era platform mounds in the Arkansas River valley. The mound appears to be alone on the landscape, not connected to a group of surrounding mounds and not located within or near a contemporaneous settlement. It overlooks the Poteau/ Arkansas River bottoms to the west and was probably visible from both the Spiro and Skidgel sites in prehistoric times.

Objetivos: O presente estudo teve como objetivo relatar a análise de um prontuário de paciente submetido ao tratamento de uma queimadura por hipoclorito de sódio em mucosa oral devido à extravasamento de hipoclorito de sódio durante o tratamento endodôntico. Materiais e Métodos: Através da análise de prontuários de pacientes atendidos na disciplina de Estágio Supervisionado do Complexo Odontológico da FSG Centro Universitário entre os anos de 2017 e 2018, selecionou-se um prontuário de um paciente que sofreu queimadura acidental devido ao extravasamento de hipoclorito de sódio. Resultados: O extravasamento de hipoclorito resultou numa lesão por queimadura na lingual do elemento 45. Como medidas, o paciente foi orientado a usar medicação sistêmica, medicamento Ad-Muc® associado a bochechos com clorexidina a 0,12% e sessões de laserterapia de baixa intensidade. Conclusão: O presente relato destaca os problemas associados ao extravasamento acidental de solução irrigadora à base de hipoclorito de sódio. O adequado diagnóstico, juntamente com a conduta adotada, associando medicação sistêmica, tópica e realização de laserterapia, neste caso, se mostrou efetiva.Descritores: Endodontia; Hipoclorito de Sódio; Acidentes.ReferênciasNoites R, Carvalho MF, Vaz IP. Complicações que podem surgir durante o uso do hipoclorito de sódio no tratamento endodôntico. Rev Port Estomatol Cir Maxilofac. 2009; 50(1):53-56.Salum G, Barros Filho S, Rangel LFGO, Rosa RH, dos Santos SSF, Leão MVP. Hipersensibilidade ao hipoclorito de sódio em intervenções endodônticas. Rev Odontol Univ São Paulo. 2012;24(3):200-8.Borin G, Becker AN, Oliveira EPM. A história do hipoclorito de sódio e a sua importância como substância auxiliar no preparo químico mecânico de canais radiculares. Rev Endod Pesq Ensino On Line. 2007;3(5):1-5.Witton R, Brennan PA. Severe tissue damage and neurologic defict following extravasation of sodium hypochlorite solution during routine endodontic treatment. Br Dent J. 2005; 198(12):749-50.Bramante CM, Duque JA, Cavenago BC, Vivan RR, Bramante AS, Andrade FB, Duarte MAH. Use of a 660-nm laser to aid in the healing of necrotic alveolar mucosa caused by extruded sodium hypochlorite: a case report. J Endod. 2015;41(11):1899-902.Tenore G, Palaia G, Ciolfi C, Mohsen M, Battisti A, Romeu U. Subcutaneous emphysema during root canal therapy: endodontic accident by sodium hypoclorite. Ann Stomatol (Roma). 2017; 8(3):117-122.Hulsmann M, Hahn W. Complications during root canal irrigation – literature review and case reports. Int Endod J. 2000;33(3):186-93.Silva JPM, Boijink D. Acidente com hipoclorito de sódio durante tratamento endodôntico: Análise de prontuário. Rev Odontol Araçatuba. 2019;40(1):25-8.Ribeiro MS, Silva DFT, Zezell DM, Nunez SC. Laser de baixa intensidade. A Odontologia e o laser. São Paulo: Quintessense; 2004.Azzi VJB, Di Pietro SN. Aplicação da laserterapia no tratamento de queimaduras: uma revisão sistemática. Rev Bras Terap e Saúde. 2012;3(1):15-26.Graça BP. O Hipoclorito de sódio em Endodontia [dissertação]. Porto: Faculdade de Ciências da Saúde/Universidade Fernando Pessoa; 2014.Gursoy UK, Bostanci V, Kosger HH. Palatal mucosa necrosis because of accidental sodium hypochlorite injection instead of anaesthetic solution. Int Endod J. 2006;39(2):157-61.Freitas RPA, Barcelos APM, Nóbrega BM, Macedo AB, Oliveira AR, Ramos AMO et al. Laserterapia e microcorrente na cicatrização de queimadura em ratos: terapias associadas ou isoladas?. Fisioter Pesqui. 2013;20(1):24-30.Prockt AP, Takahashi A, Pagnoncelli RM. Uso de terapia com laser de baixa intensidade na cirurgia bucomaxilofacial. Rev Port Estomatol Cir Maxilofac. 2008;49(4):247-55.Noba C, Mello-Moura ACV, Gimenez T, Tedesco TK, Moura-Netto C. Laser for bone healing after oral surgery: systematic review. Lasers med Sci. 2018;33(3):667-74.Rocha Júnior AM, Oliveira RG, Farias RE, Andrade LCF, Aarestrup FM. Modulação da proliferação fibroblástica e da resposta inflamatória pela terapia a laser de baixa intensidade no processo de reparo tecidual. An Bras Dermatol. 2006;81(2):150-56.Soares RG, Dagnese C, Irala LED, Salles AA, Limongi O. Injeção acidental de hipoclorito de sódio na região periapical durante tratamento endodôntico: relato de caso. RSBO. 2006; 4(1):17-21.Doherty MAH, Thomas MBM, Dummer PMH. Sodium hypochlorite accident – a complication of poor access cavity design. Dent Update. 2009;36(1):7-12.

A má oclusão classe II de Angle é uma oclusopatia de alta prevalência na população brasileira, com grandes impactos nas estruturas dentárias, ósseas, bem como na qualidade de vida dos indivíduos. O objetivo deste estudo foi relatar a eficácia do arco seccionado de forças paralelas, no tratamento da classe II divisão 1. O caso clínico refere-se a uma paciente do sexo feminino de 19 anos de idade. O tratamento da má oclusão foi iniciado com o uso do Arco Utilidade ou Arco Base Inferior, a fim de nivelar e corrigir as interferências antero-posteriores, bem como possibilitar a ancoragem do molar inferior. Em seguida utilizou-se o Arco Seccionado de Forças Paralelas, associado ao uso de elástico 5/16 médio, a fim de potencializar a distalização do molar superior, eliminando os efeitos indesejáveis pelo uso do elástico intermaxilar. Após a correção da posição molar em classe I, foram feitos os ajustes finais de fechamento de diastemas, nivelamento e alinhamento. Conclui-se que o tratamento da classe II divisão 1, com base na terapia bioprogressiva com o uso dos arcos seccionados de forças paralelas foi altamente eficaz, possibilitando além da correção da má oclusão, garantir a estabilidade oclusal e a harmonia do perfil facial da paciente.Descritores: Má Oclusão; Má Oclusão de Angle Classe II; Ortodontia Corretiva.ReferênciasBauman JM, Souza JGS, Bauman CD, Florido FM. Aspectos sociodemográficos relacionados à gravidade da maloclusão em crianças brasileiras de 12 anos. Ciênc. saúde coletiva. 2018;23(3):723-32.Campos FL, Vazquez FL, Cortellazzi KL, Guerra LM, Ambrosano GMB, Meneghim MC et al. A má oclusão e sua associação com variáveis socioeconômicas, hábitos e cuidados em crianças de cinco anos de idade. Rev Odontol UNESP. 2013;42(3):160-66.Angle EH. Classification of malocclusion. Dental Cosmos.1899;41:248-64.Arruda RT, Cruz CM, Crepaldi MV, Santana AP, Guimaraes Junior CH. Trtamento precoce da classe II: relato de caso. R Faipe. 2017;7(1):25-35.Garbin AJI, Grieco FAD, Rossi LB. Ortodontia de visão. Ribeirão Preto: Editora Tota, 2016.Seehra J, Newton JT, Dibiase AT. Interceptive orthodontic treatment in bullied adolescents and its impact on self-esteem and oral-health-related quality of life. Eur J Orthod. 2013;35(5):615-21.Gatto RCJ, Garbin AJI, Corrente JE, Garbin CAS. Self-esteem level of Brazilian teenagers victims of bullying and its relation with the need of orthodontic treatment. RGO Rev Gaúch Odontol. 2017;65(1):30-6.Gatto RCJ, Garbin AJI, Corrente JE, Garbin CAS. The relationship between oral health-related quality of life, the need for orthodontic treatment and bullying, among Brazilian teenagers. Dental Press J. Orthod. 2019;4(2):73-80.Dibiase A, Sandler PJ. Early treatment of Class II malocclusion. In: Cobourne MT. (eds) Orthodontic management of the developing dentition. Springer: Cham; 2017. p.151-67.Janson G, Barros SEC, Simão TM, Freitas MR. Variáveis relevantes no tratamento da má oclusão de Classe II. R Dental Press Ortodon Ortop Facial. 2009;14(4):149-57.Gimenez CMM, Bertoz APM, Bertoz FA, Vedovello Filho M, Tubel CAM. Momento Oportuno para a Abordagem Ortodôntica no Tratamento da Classe II. UNOPAR Cient Ciênc Biol Saúde. 2010;12(3):5-10.Capistrano A, Xerez JE, Tavares S, Borba D, Pedrin RRA. APM/FLF no tratamento da Classe II em adulto: 8 anos de acompanhamento. Rev Clín Ortod Dental Press. 2018;17(2):58-71Ricketts RM, Bench RW, Gugino CF, Hilgers. JJ, Schulhof RJ. Bioprogressive Therapy. Denver: Rocky Mountain Orthodontics; 1979.Garbin AJI, Grieco FAD, Guedes-Pinto E. Bioprogressiva e reabilitação neuro-oclusal: a evolução da Ortodontia. Araçatuba: Editora Somos; 2009.Tadesco AF, Oppermann NJ, Duarte MS, Cunha FL, Cavenaghi M. Avaliação do comportamento do eixo facial em pacientes classe II divisão 1, tratados sem extração, com mecânica secccionada e elásticos. RGO. 2005;53(1):67-70.Ferreira FM, Garbin AJI, Grieco FAD, Rossi LP. Arco seccionado de forças paralelas no tratamento da má oclusão de classe II. Ortho Sci Orthod sci pract. 2014;7(25):58-69.Lopes MAP, Santos DCL, Negrete D, Flaiban E. O uso de distalizadores para a correção da má oclusão de Classe II. Rev. Odontol Univ Cid São Paulo. 2013;25(3):223-32.Ricketts RM. Cephalometric analysis and synthesis. Angle Orthod, Appleton, 1961;31(3):141-56. Sahad MG, Grieco FAD, Cartaxo ZBP, Guedes Pinto E, Prokopowitsch I, Araki ÂT. Tratamento da má oclusão de Classe II, subdivisão direita, segundo a terapia bioprogressiva. Rev Clín Ortod Dental. Press 2012; 11(1):92-7.Aranha MF, Garbin AJI, Grieco FAD, Guedes Pinto E, Mendonça MR. Utilização dos arcos seccionados para o tratamento da má oclusão classe II, divisão 2. Rev Clín Ortod Dental Press. 2010;9(3):51-56.Garbin AJI, Wakayama B, Teruel GP. Tratamento da classe II divisão 1 – uma abordagem terapêutica com a mecânica bioprogressiva e arco seccionado de forças paralelas. Rev UNINGÁ; 2019;56(S3):71-83.Loriato LB, Machado AW, Pacheco W. Considerações clínicas e biomecânicas de elásticos em ortodontia. R Clin Ortodon Dental Press. 2006;5(1):42-55.

O aumento da urbanização das cidades brasileiras, muitas vezes sem planejamento, têm provocado sérios danos ambientais e prejuízos à saúde dos seus moradores. As áreas arborizadas apresentam inúmeros efeitos benéficos no microclima – temperatura e umidade do ar, fatores que contribuem na melhoria do conforto térmico e qualidade de vida dos munícipes. O objetivo deste trabalho foi realizar um estudo descritivo e quantitativo quanto às diferenças de temperatura e umidade relativa do ar em dois locais de um conjunto habitacional denominado Braz Cavenaghi, município de Itapira-SP, com características semelhantes de área, destacando-se pela diferença da vegetação arbórea existente e como essa vegetação pode favorecer conforto térmico dos moradores. Os dados foram coletados em uma área bem arborizada e em um local desprovido de vegetação. Os resultados mostraram que a arborização urbana influencia os valores de temperatura e umidade relativa do ar favorecendo a redução do calor gerado nesse ambiente, ampliação das taxas de evapotranspiração com aumento da umidade do ar desempenhando assim, um importante papel na melhoria das condições ambientais das cidades e qualidade de vida de seus habitantes.Descritores: Microclima; Planejamento de Cidades; Nascentes Naturais.ReferênciasPinheiro CR, Souza DD. A importância da arborização nas cidades e sua influência no microclima. R gest Sust Ambient. Florianópolis. 2017;6(1):67-82.Labaki LC. Vegetação e conforto térmico em espaços urbanos abertos. Fórum Patrimônio. 2011;4(1):23-42.Oliveira MM, Alves WS. A influência da vegetação no clima urbano de cidades pequenas: um estudo sobre as praças públicas de Iporá-GO. Rev Territorial. 2013;2(2):61-77.Abreu LV. Avaliação da escala de influência da vegetação no microclima por diferentes espécies arbóreas [dissertação]. 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