Dissertations / Theses on the topic 'CATIONIC MICELLES'
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Schnee, Vincent Patrick. "The characterization of cationic pseudostationary phases for electrokinetic chromatography." CONNECT TO THIS TITLE ONLINE, 2007. http://etd.lib.umt.edu/theses/available/etd-05222008-102001/.
Full textZhou, Xing Zhi. "Cationic polypeptide-based micelles for camptothecin delivery in lung cancer therapy." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952141.
Full textFaivre, Valérie. "Étude des propriétés esterolytiques de complexes hydrophobes 2-hydroxymethylbenzimidazole-zn+² en présence de micelles cationiques (CTAB)." Vandoeuvre-les-Nancy, INPL, 1993. http://www.theses.fr/1993INPL008N.
Full textErgican, Erdogan. "Molecular level separation of arsenic (V) from drinking water using cationic micelles and ultrafiltration membrane." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3210067.
Full textSkoglund, Sara. "Self-assembly in mixtures of an anionic and a cationic surfactant: A comparison between static light scattering and cryotransmission electron microscopy." Thesis, KTH, Skolan för kemivetenskap (CHE), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-34032.
Full textKashapov, Ruslan R., Tatiana N. Pashirova, Sergey V. Kharlamov, Albina Yu Ziganshina, Elena P. Ziltsova, Svetlana S. Lukashenko, Lucia Ya Zakharova, Wolf D. Habicher, Shamil K. Latypov, and Alexander I. Konovalov. "Novel self-assembling system based on resorcinarene and cationic surfactant." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-138802.
Full textDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
Kashapov, Ruslan R., Tatiana N. Pashirova, Sergey V. Kharlamov, Albina Yu Ziganshina, Elena P. Ziltsova, Svetlana S. Lukashenko, Lucia Ya Zakharova, Wolf D. Habicher, Shamil K. Latypov, and Alexander I. Konovalov. "Novel self-assembling system based on resorcinarene and cationic surfactant." Royal Society of Chemistry, 2011. https://tud.qucosa.de/id/qucosa%3A27782.
Full textDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Pires, Paulo Augusto Rodrigues. "Síntese e propriedades de soluções de tensoativos catiônicos derivados de (3-dimetilaminopropil)amidas de ácidos carboxílicos." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-06102003-163601/.
Full textThe following surfactants have been synthesized: benzyl-(3-acyl-aminopropyl)dimethylammonium chloride, RCONH(CH'ind.2')'ind.3'N'pot.+'(CH'ind.3')'ind.2'CH'ind.2'C'ind.6'H'ind.5' Cl'pot.-' and (3-acylaminopropyl) trimethylammonium chloride, RCONH(CH'ind.2')'ind.3'N'pot.+'(CH'ind.3')'ind.3' Cl'ind.-', where RCO = C'ind.10' to C'ind.16'. The two series have been synthesized from the precursor RCONH(CH2)3N(CH3)2, by quaternization with benzyl chloride, and/or methyl iodide (followed by ion exchange), respectively. Adsorption at solution/air interface and micellization in aqueous solution has been studied, and the results compared with those of other cationic surfactants. Some properties, e.g., critical micelle concentrations, degrees of micelle dissociation, and aggregation numbers are similar to those of other cationic surfactants of equivalent hydrophobic chain length. The Gibbs free energies of adsorption at solution/air interface, and of micellization are, however, more favorable. The group [-CO-NH-CH'ind.2'-CH'ind.2'-CH'ind.2'-] is a part of the interface, and lead to favorable micellization. The microscopic polarity of interfacial water has been measured by appropriate solvatochromic probes, and is less than that of bulk water.
Ashrafizadeh, Seyed Nezameddin. "Cation exchange with reverse-micelles." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61109.
Full textThe HD reverse-micellar extraction system exhibited behavior similar to that of conventional ion-exchange resin systems. A preferential extraction for Mg$ sp{++}$ over K$ sp+$ was observed. The efficiency of the extraction was high for low salt concentrations and it was independent of surfactant concentration. The amount of water uptake was low, with W$ sb{o}$ ranging between 4 and 10. For a wide range of salt and surfactant concentrations W$ sb{o}$ was independent of surfactant concentration. The HD surfactant showed a low solubility in the aqueous phase.
The results of the equilibrium partition experiments were correlated using a thermodynamic model. Interaction parameters determined from binary system experimental data were used to predict the ternary system partition behavior. The ternary system predictions were compared with experimental results and found to be satisfactory.
Gélinas, Stéphanie. "Micellar-enhanced ultrafiltration using a twin-head cationic surfactant." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23262.
Full textSolubilization tests and MEUF experiments were performed with an aqueous feed solution of benzoic acid (molecular weight 122) and Rhodameen T12/90 (molecular weight 798), a twin-head, cationic tertiary amine surfactant. This surfactant has an 18 carbon hydrophobic tail and two hydrophilic polyoxyethylene heads. The equilibrium solubilization of benzoic acid by surfactant solutions was measured by semiquilibrium dialysis. The maximum solubilization was nearly one mole of benzoic acid per mole of Rhodameen.
MEUF was carried out in hollow fiber polysulfone membrane units with MWCO of 5,000 and 30,000. The permeate flux and overall rejection of benzoic acid and surfactant were measured for different initial feed compositions and initial surfactant concentrations under varying transmembrane pressures (TMP). The flux increased with TMP and decreased with Rhodameen concentration, but was not affected by the benzoic acid concentration. The highest rejections of benzoic acid (90%) and Rhodameen (95%) were obtained when the molar ratio of surfactant to solute in the feed was 1.2.
Bertoncini, Clelia Rejane Antonio. "Efeito de aditivos em micelas cationicas." reponame:Repositório Institucional da UFSC, 1989. http://repositorio.ufsc.br/xmlui/handle/123456789/75544.
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Micelas catiônicas de brometo e hidróxido de cetiltrietilamônio (CTEABr e CTEAOH) têm suas propriedades físico-químicas afetadas pela adição de n-butanol (BuOH). Através de medidas de condutividade, a 25oC, foram determinados os valores de CMC e a destes detergentes, em soluções aquosas na presença de BuOH. A CMC diminui em baixas concentrações e aumenta em altas concentrações de BuOH, enquanto que o valor de a aumenta continuamente com adição de BuOH. Os efeitos da adição de BuOH e NaBr nas propriedades catalíticas de CTABr e CTEABr, a 25oC, foram estudados através de medidas de constantes de velocidade para a reação de b-naftalenossulfonato de metila com íon brometo, sendo que a constante de velocidade diminui com a adição de BuOH. Os dados cinéticos podem ser explicados considerando que: i) a concentração de contra-íons reativos na superfície micelar não é constante, ou seja muda com a adição de BuOH e/ou NaBr; ii) a constante de ligação do substrato à micela depende da BuOH; iii) existe uma constante de velocidade para a decomposição espontânea do substrato e iv) a constante de ligação do BuOH à micela é descrita através de uma constante de distribuição de valor K = 1M-1. Feitas essas considerações, foram calculados valores de km = 9,1 x 10-4 de distribuição para o CTABr e km = 13,8 x 10-4 s-1 para o CTERABr, os quais ajustam perfeitamente os dados experimentais.
Wang, Wenhua 1960. "Reverse micellar extraction of amino acids using the two-tailed cationic surfactant DODMAC." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28954.
Full textThe effects of pH and of the concentrations of amino acid, NaCl, DODMAC and l-decanol on the reverse micellar extraction of aspartic acid, glutamic acid and threonine from aqueous salt solutions were determined by phase contact experiments. The concentrations of all ionic species in the aqueous phase were measured and the corresponding concentrations inside the reverse micelles were obtained by material balances and the condition of electrical neutrality. The results show that the amino acids were mainly extracted through an ion exchange mechanism. Important factors which dominate the amino acid extraction are the net charge of amino acid, the competition among anions, the dissociation equilibrium of DODMAC and the water uptake in the reverse micelles. The ionic species in the reverse micelles tend toward their undissociated states as the water uptake by the reverse micelles decreases.
The renormalization of Guggenheim's canonical partition function to satisfy the limits of order and disorder has been used to generate excess Gibbs energy models for liquid mixtures. Under well defined assumptions, the contributions to the activity coefficients arising from the new partition function correspond exactly with those given by existing semi-empirical models.
A thermodynamic model has been developed to calculate the concentrations of all ionic species in both the aqueous and the reverse micellar phases. With this model it is possible to study the effect of changes of extraction variables, such as the concentrations of salt, surfactant and cosurfactant, in the extraction of amino acids by reverse micelles. The model has been tested by performing flash calculations for the system DODMAC, l-decanol isooctane, NaCl an amino acid and water. Three different amino acids were considered. The calculated results are in good agreement with the experimental data.
Peroza, Meza Carlos Arturo. "Factors affecting the alkaline hydrolysis of carbaryl in the presence of cationic surfactants." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/6248.
Full textLardet, Dominique. "Influence des milieux micellaires sur la solvolyse des radicaux cations des dérivés de la phénothiazine." Lyon 1, 1986. http://www.theses.fr/1986LYO19014.
Full textSanson, Nicolas. "Assemblages induits de copolymères à blocs double hydrophiles (DHBC) et de cations métalliques multivalents : Nouveaux précurseurs de nanoparticules hybrides." Montpellier 2, 2005. http://www.theses.fr/2005MON20037.
Full textBen, Chaabane Tahar. "Transfert d'électron en micelles et vésicules : effet du potentiel électrique interfacial." Paris 11, 1987. http://www.theses.fr/1987PA112188.
Full textHaramagatti, Chandrashekara Rajashekara. "Structure, dynamics and phase behaviors of cationic micellar solutions raman and neutron scattering study of alkyltrimethylammonium bromides /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982482361.
Full textHassan, Raeisi Azadeh [Verfasser]. "Investigation of hydrophobically modified polyacrylamide gels prepared in micellar solutions of a cationic surfactant / Azadeh Hassan Raeisi." Clausthal-Zellerfeld : Universitätsbibliothek Clausthal, 2014. http://d-nb.info/1051940516/34.
Full textBelmajdoub, Abdelaly. "Étude comparative des systèmes micellaires bromure de cetyltrimethylammonium/eau lourde et bromure de cétyltriméthylammonium/fromamide par relaxation magnétique nucléaire multichamp/multifréquence des isotopes **(1)H, **(2)H, **(14)N, **(13)C, et **(17)O." Nancy 1, 1988. http://www.theses.fr/1988NAN10250.
Full textLeifsdotter, Josefine. "Investigation of the micelle-to-vesicle transition in mixtures of an anionic and a cationic surfactant: the effect of adding salt." Thesis, KTH, Skolan för kemivetenskap (CHE), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-158474.
Full textDupont-Leclercq, Laurence Rubini Patrice Henry Bernard. "Etude cinétique et thermodynamique de réactions d'échange de protons et de complexation de cations métalliques en milieu micellaire." S. l. : S. n, 2009. http://www.scd.uhp-nancy.fr/docnum/SCD_T_2009_0057_DUPONT-LECLERCQ.pdf.
Full textLin, Zhiqing. "The effect of chemical structures of cationic surfactants or counterions on solution drag reduction effectiveness, rheology and micellar microstructure /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488203552779718.
Full textAmado, André Miele. "Agregação da acridina laranja em soluções aquosas e na interação com micelas de SDS." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-17042013-095936/.
Full textIn this work we present an experimental study of Acridine Orange (AO) aggregation in homogeneous aqueous solutions and its interaction with a surfactant Sodium Dodecyl Sulfate (SDS). The objective of this study was to define the structure and temporal characteristics of aggregates of organic compounds with developed-conjugated system, used as photosensitizers and probes of biological structures, in its interaction with heterogeneous nano-structures. The information on photosensitizer aggregation characteristics is important as this process would affect its efficiency in practical applications, in biology and medicine, in particular. AO was chosen as a model for the following reasons: AO is a known compound with various characteristics well described in literature; AO has a high fluorescence quantum yield, high photoactivity, high affinity to biological structures (cell membrane, DNA and RNA, in particular), therefore, AO is widely used as a fluorescent marker and a photosensitizer in phototherapy; AO possesses a tendency to aggregate in aqueous solution. The aggregation of AO modifies essentially its absorption and fluorescence spectra, decreases the lifetime and quantum yield of its excited states. This makes AO a suitable model for studying the aggregation phenomenon. We have analyzed optical absorption, fluorescence and resonant light scattering spectra in the static mode and as a function of time as well as the dynamic light scattering for various AL and SDS concentrations. It was found that: in aqueous solutions AO forms H aggregates; The increase in concentration of AO in homogeneous solutions induces an increase in its aggregation number; The presence of salt stimulates aggregation due to decrease of electrostatic repulsion between AO molecules; The SDS concentrations above 60 M stimulate AO aggregation inducing the formation of mixed nAL + mSDS aggregates; Mixed nAL + mSDS aggregates are characterized by flexibility and instability; Transformation dynamics of the mixed aggregates is characterized by four components, the first one with a characteristic time <36 and the other three with times ranging from minutes to several hours; AO aggregation in a solution decreases its fluorescence and increases the resonant light scattering intensities; SDS at high concentrations reduces AO aggregation number until its monomeric form bound with SDS aggregates and / or micelles; AO monomers bound with SDS micelles possess higher fluorescence intensity as compared with that in homogeneous aqueous solutions. Our research shows that aggregation modifies efficacy of photosensitizers at their application. This has always to be considered especially due to its prolonged dynamics as the photosensitizer characteristics are modifying continuously during its application.
Wang, Bin. "Utility of Cationic and Anionic Chiral Surfactants in Capillary Electrophoresis (CE) and CE Coupled to Mass Spectrometry (CE-MS)." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_theses/16.
Full textNgo, Thi Huong Viet. "Synthèse et propriétés amphiphiles de lipides cationiques à chaîne alkyle ou perfluoroalkyle polyfonctionnels en milieu aqueux." Thesis, Tours, 2010. http://www.theses.fr/2010TOUR4021.
Full textAmphiphilic compounds N,N,N-trimethyl-(3-N-perfluoroalkylamidopropyl)ammonium iodide (Fn-AH3-AmI) and N1,N12-Bis [3-(trimethylammonium)propyl iodide]- perfluoroalcane diamide (Fn(AH3-AmI)2) are obtained byreaction between (di)esters and 3-N,N-dimethyl-1-propylamine and thenquaternization by methyl iodide.The aqueous solution behaviour of one head compounds Fn-AH3-AmI interms of surface and aggregative properties is examined as a function oftemperature T, KI amount and ethanol, and also by varying their tail length(n = 8, 10, 12, 14) and their hydrocarbon or perfluorocarbon type.Hydrocarbon compounds associate into micelles. Micelles and vesicles cancoexist in the case of the perfluorocarbon homologues.The surface and aggregatives properties of the bolaforms Fn(AH3-AmI)2 (n =6, 8, 10) are also examinated as a function of T, KI and the hydrophobic tailstructure. The aggregate formation is thought to be attributed to the bendingability of the bolaforms.Fn-AH3-AmI and Fn(AH3-AmI)2 compounds are involved in the formulationof vesicles whose size is examinated as a function of the co-lipid 1,2-dioleoylsn-glycero-3-phosphatidylethanolamine (DOPE) amount
Dupont-Leclercq, Laurence. "Etude cinétique et thermodynamique de réactions d'échange de protons et de complexation de cations métalliques en milieu micellaire." Thesis, Nancy 1, 2009. http://www.theses.fr/2009NAN10057/document.
Full textThis study aims at understanding the influence of micellar media on the thermodynamics and the kinetics of cations complexation and proton transfer. Two kinds of systems were studied: - On the one hand, we studied molecules which self-organize in micelles such as amphiphilic ammonium salts, to investigate the kinetics of proton transfer and alkylpolyglucosides, to determine the thermodynamics of Cu(II) complexation. - On the other hand, we analysed acid-base reactions and Cu(II) complexation involving original tartaric acid derivatives which can be solubilized in non-ionic micelles. Deep modifications of thermodynamics and kinetics parameters in the presence of micelles were demonstrated and interpreted from a fundamental point of view. We took advantages of these changes to develop new analytical techniques for CMC measurements, determination of water-micelles partition constants, identification of species solubilized in the micellar pseudophase and interpretation of the variation of Cu(II) micellar extraction yields as a function of pH. To perform these experiments, various analytical techniques were used: nuclear magnetic resonance (Dynamic and Static NMR), pHmetry, UV-visible and circular dichroism spectroscopies, micellar enhanced-ultrafiltration. The use of these techniques in micellar media was discussed
Bate, Bate. "Engineering behavior of fine-grained soils modified with a controlled organic phase." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39627.
Full textBohunská, Miroslava. "Studium interakcí tenzidové složky přípravku Septonex s vybranými proteiny." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449410.
Full textQuainoo, Emmanuel W0bil. "METHOD DEVELOPMENT AND INVESTIGATION OF FLUORESCENT PHOSPHOINOSITIDE CELL SIGNALING PROPERTIES BY CAPILLARY ELECTROPHORESIS." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693846.
Full textMalinenko, Alla. "Effet d’ion specifique sur l’auto-assemblage d’amphiphiles cationiques : des approches experimentale et informatique." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0065/document.
Full textThe present study is a holistic approach focused on the investigation of ion specific effects on the self-assembly properties of cationic gemini surfactants. Our main focus was on the effect of various counterions on the self-organization features of cationic surfactants in aqueous solution. In order to obtain amore comprehensive understanding of the effect of interfacial ionic and molecular interactions on aggregate properties we used different approaches. We combined an experimental study focused on the bulk solution properties (critical micelle concentration, ionization degree, aggregation number, etc.), with approaches focused on investigating the interfacial micellar properties by analyzing the interfacial counterion and waterconcentrations, experimentally (chemical trapping) and computationally (molecular dynamic simulations). Moreover, the impact of counterion nature was investigated by studying the growth of wormlike micelles using rheology. Besides the examination of the surfactants properties in solution, the ion specific effects onthe crystalline structures of gemini surfactants were studied.We found that ion specific effects which determine the behavior of micellar aggregates of cationic quaternary ammonium gemini in aqueous solutions strongly depend on the free energy of hydration of the counterions, in others words, on their hydrophilic/hydrophobic properties. Contrarily to aqueous solution, in crystals, the size of the ion becomes the determining factor. Comparison of the results obtained for the same system in aqueous solution and in solid state showed the importance of ion-water interactions in ion specific effects. However, one should note that the properties of substrate (the gemini in our case) should be taken into account not less carefully in order to fully predict Hofmeister effects
Bahri, Hamed. "Thermodynamique dans les milieux diphasés dispersés : cas des solutions micellaires et des microémulsions." Paris 6, 1986. http://www.theses.fr/1986PA066280.
Full textMader, Dorathea Felicitas. "Relation structure - propriétés de commutation dans les matériaux à transition de spin : effet de nanostructuration et de dilution du cation métallique." Thesis, Nancy 1, 2011. http://www.theses.fr/2011NAN10124/document.
Full textIn the last years, intensive research activity has been dedicated to iron(II)-based spin transition compounds, for a better understanding of the fundamental phenomena as within the scope of practical application. These molecular materials possess two electronic configurations, which are interchangeable by the application of an external perturbation (thermal and optic bistability). Strong electron-lattice coupling may lead to cooperative behaviour, consequently abrupt spin transitions and hysteretic behaviour at the origin of a memory effect. Understanding and controlling this property is of primary interest in fundamental and applied research. The influence of metal dilution on the photo-induced transitions in FexZn1-x(btr)2(NCS)2.H2O is investigated by X-Ray diffraction on single crystals. We suggest a microscopic model interpreting the dynamics of the phase transition (nucleation and growth mechanisms of spin-like domains) through a structural analysis of the diffraction data. The effects of nanostructuration on the physicochemical properties have been studied on the one-dimensional coordination polymer [Fe(Htrz)2trz](BF4). Different surfactant-based organized molecular systems with various structural organizations are chosen for the synthesis in confined environments: reverse micellar solutions as well as lamellar (Lalpha) and reverse hexagonal (HII) liquid crystal phases. A relationship between size and shape, microstructure and physicochemical properties is established with a specific attention to reaction dynamics in the liquid crystal phase
Vitart, Xavier. "Contribution a l'extraction liquide-liquide et a la separation de certains elements du groupe viii, notamment du ruthenium, par des systemes synergiques polyimines aromatiques-echangeurs cationiques micellaires." Paris 6, 1987. http://www.theses.fr/1987PA066663.
Full textBerlot, Isabelle. "Synthèse, caractérisation et étude électrochimique de tensioactifs dérivés du pyrrole." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10087.
Full textHahn, Jungseok. "Deposition of cationic polymer micelles on planar and patterned SiO₂ surfaces." 2003. http://hdl.handle.net/2152/12109.
Full textHahn, Jungseok Webber Stephen E. "Deposition of cationic polymer micelles on planar and patterned SiO₂ surfaces." 2003. http://wwwlib.umi.com/cr/utexas/fullcit?p3119625.
Full textSoliman, Ghareb Mohamed. "Polysaccharide-based Polyion Complex Micelles as New Delivery Systems for Hydrophilic Cationic Drugs." Thèse, 2009. http://hdl.handle.net/1866/3844.
Full textPolyion complex (PIC) micelles have emerged as promising delivery systems of ionic hydrophilic drugs. It was the aim of this study to develop dextran-based PIC micelles for the delivery of hydrophilic cationic drugs using a new family of carboxymethyldextranblock- poly(ethylene glycol) (CMD-PEG) copolymers. Four CMD-PEG copolymers were prepared: (i) two copolymers identical in terms of the length of CMD and PEG blocks, but different in terms of the charge density of the CMD block; and (ii) two copolymers in which the charged block is the same, but the PEG block is of different molecular weight. The micellization of CMD-PEG copolymers and drug delivery aspects of the resulting micelles were evaluated using different cationic drugs: diminazene (DIM), a model cationic drug, minocycline hydrochloride (MH), a semisynthetic tetracycline antibiotic with promising neuroprotective properties and different aminoglycoside antibiotics. The cytotoxicity of CMD-PEG copolymers was evaluated in different cell lines using MTT and Alamar blue assays. CMD-PEG micelles encapsulating different drugs were characterized using different techniques, such as 1H NMR spectroscopy, dynamic light scattering (DLS), and isothermal titration calorimetry (ITC). The pattern of drug release and pharmacological activity of micelles-encapsulated drugs were also evaluated. The CMD-PEG copolymers did not induce cytotoxicity in human hepatocytes and murine microglia (N9) in concentrations as high as 15 mg/mL after incubation for 24 h. Electrostatic interactions between CMD-PEG copolymers and different cationic drugs triggered the formation of PIC micelles with a CMD/drug core and a PEG corona. The properties of DIM/CMD-PEG micelles were strongly dependent on the degree of carboxymethylation of the CMD block. Micelles of CMD-PEG copolymers having degree of carboxymethylation ≥ 60%, incorporated up to 64 wt% DIM, resisted salt-induced disintegration in solutions up to 400 mM NaCl and sustained DIM release under physiological conditions (pH 7.4, 150 mM NaCl). In contrast, micelles of CMD-PEG of degree of carboxymethylation ~ 30% had lower drug content (~ 40 wt% DIM) and disintegrated at lower salt concentration (∼ 100 mM NaCl). The CMD-PEG copolymer that showed the most satisfactory micellar properties, in terms of high drug loading capacity, sustained drug release and micelles stability was selected as a potential delivery system of minocycline hydrochloride (MH) and different aminoglycosides. CMD-PEG micelles encapsulating either MH or aminoglycosides had small size (< 200 nm in diameter), high drug loading capacity (≥ 50 wt% drug) and sustained drug release. These micelles were stable in aqueous solution for up to one month, after freeze drying and in the presence of bovine serum albumin. Furthermore, the micelles protected MH against degradation in aqueous solutions. Micelles-encapsulated drugs maintained their pharmacological activity where MH micelles reduced lipopolysaccharides-induced inflammation in murine microglia (N9) cells. And aminoglycosides micelles were able to kill a test micro-organism (E. coli X-1 blue strain) in culture. Aminoglycosides/CMD-PEG micelles were unstable under physiological conditions. Micelle properties were greatly enhanced by hydrophobic modification of CMD-PEG. Thus, aminoglycosides/dodecyl-CMD-PEG micelles showed smaller size and better stability under physiological conditions. The results obtained in this study show that CMD-PEG copolymers are promising delivery systems for cationic hydrophilic drugs.
Feng, Tzu-Hua, and 馮子驊. "Synthesis and Characterization of Star-Shaped Cationic Copolymer Hybrid Micelles as a Gene Vector." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/52853289244065649927.
Full text高雄醫學大學
醫藥暨應用化學研究所
100
In this study, amphiphilic star-shaped cationic copolymers were synthesized of hydrophobic monomer and hydrophilic cationic monomer. The synthesized polymer was determined by 1H-NMR spectroscopy and gel permeation chromatography (GPC). The synthesized star-shaped cationic copolymer micelles and hybrid micelles contained PEG are formed by oil-in-water solvent evaporation method. The polyplex binding ability, transfection efficiency and cytotoxicity of micelles are all compared by gel electrophoresis performance, luciferase assay and MTT assay.
Fang, I.-Ju, and 方怡茹. "Capillary Electrophoretic Studies on Influence of Interactions of Cationic Solutes with Sodium Dodecyl Sulfate on the Formation of Micelles and its Critical Micelle Concentration." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/78468409324891983767.
Full text國立臺灣大學
化學研究所
92
Abstract The migration behavior of cationic solutes and influences of the interactions of cationic solutes with sodium dodecyl sulfate (SDS) on the formation of micelles and its critical micelle concentration (CMC) were investigated by capillary electrophoresis at neutral/acidic pH. Catecholamines and structurally related compounds, including epinephrine, norepinephrine, dopamine, norephedrine, and tyramine, which involve different extents of hydrophobic, ionic and hydrogen bonding interactions with SDS surfactant, are selected as cationic solutes. The dependence of the effective electrophoretic mobility of cationic solutes on the concentration of SDS monomers in the premicellar region provides direct evidence of the formation of ion-pairs between cationic solutes and SDS monomers. Three different approaches, based on the variations of either the effective electrophoretic mobility or the retention factor as a function of SDS concentration in the premicellar and micellar regions, and the linear relationship between the retention factor and the product of a distribution coefficient and the phase ratio, were considered to determine the CMC value of SDS micelles. The suitability of the methods used for the determination of the CMC of SDS with these cationic solutes was discussed. Depending on the structures of cationic solutes and electrophoretic conditions, the CMC value of SDS determined varies in a wide concentration range. The results indicate that, in addition to hydrophobic interaction, both ionic and hydrogen bonding interactions have pronounced effects on the formation of SDS micelles. Ionic interaction between cationic solutes and SDS surfactant stabilizes the SDS micelles, whereas hydrogen bonding interactions weakens the solubilization of the attractive ionic interaction. The elevation of the CMC of SDS depends heavily on hydrogen bonding interactions between cationic solutes and SDS surfactant. Thus the CMC value of SDS is remarkably elevated with catecholamines, such as epinephrine and norepinephrine, as compared with norephedrine. In addition, the effect of methanol content in the sample solution of these cationic solutes on the CMC of SDS was also examined. The binding constant of cationic solutes with SDS monomers and those of cationic solutes to SDS micelles are evaluated. The influence of ��-cyclodextrin (��-CD) on the critical micelle concentration (CMC) of sodium dodecyl sulfate (SDS) was investigated by capillary electrophoresis using cationic solutes as probe molecules at pH 7.0. The variations of the electrophoretic mobility of probe molecules as a function of surfactant concentration in both premicellar and micellar regions in the absence and presence of ��-CD was analyzed. The results indicate that, as a consequence of a strong inclusion complexation between ��-CD and SDS, the encapsulation of ��-CD with probe molecules is greatly diminished, or even vanished, in the presence of SDS. The complexes formed between ��-CD and SDS monomers exist predominantly in the form of a 1:1 stoichiometry, while complexes with a 2:1 stoichiometry reported previously in the literature as a minor component is indicative at a concentration of ��-CD exceeding about 7mM. The elevation of the CMC value of SDS depends on the concentration of ��-CD in the buffer electrolyte . The binding constants of probe molecules to ��-CD, to surfactant molecules, and to the complexes formed between ��-CD and SDS are reported.
Rajashekara, Haramagatti Chandrashekara. "Structure, Dynamics and Phase Behaviors of Cationic Micellar Solutions:." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-B612-A.
Full textPekařová, Kateřina. "Kationické povrchově aktivní látky a hodnocení jejich vlastností." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388732.
Full textChen, Wei-Ju, and 陳薇如. "Analysis of Cellular Uptake and Distribution of Cationic Micelles Complexed with Oligonucleotides and Transmenbrane Enhancers in Mammalian Cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/44901608525423901619.
Full text國立臺灣大學
生物化學暨分子生物學研究所
97
Gene therapy offers the promise of treating disease. In general, two target sites inside cells are cytoplasm or nucleus in case of delivering therapeutic molecules such as DNA, RNA, peptides and proteins by nanoparticles. There are complicated problems in targeting these molecules. It was difficult for the large charge molecules such as DNA to pass across plasma and nucleic membrane on their own. For these reasons, I developed a non-viral micelle delivery system using the surface-modified lipid nanoparticles. It was composed one positive charge lipid, called GEC-cholesterol with cholesterol, PEG lipid and biotinylated lipid. The surface-exposed biotin moiety could interact with the bifunctioned fusion protein containing streptavidin. Adding magnetic field sequentially could force the lipid nanoparticles complexed with oligonucleotides into the cytosol; meanwhile NLS associated with intracellular binding proteins then transported into the nucleus of cancer cells and rat bone marrow stem cells. The results indicated that manipulating the magnetic force could efficiently enhance nanoparrticles transported into cells. Besides, NLS-Streptavidin fusion proteins themselves couldn’t enter into the cytoplasm. But magnetic nanoparticles inside the lipid micelles were entered significantly into the nucleus with the assistant of magnetic fields. Thus, magnetic field might be benefit for targeting nanoparticles with cargos into nucleus.
Wazen, Nada. "Micelles polyioniques ternaires pour la libération intracellulaire d’oligonucleotides." Thèse, 2010. http://hdl.handle.net/1866/5100.
Full textAntisens oligonucleotides (ONs) present great potential as therapeutic agents. However, their physicochemical properties hinder their use in gene therapy. Targeting systems, such as polyion complex micelles (PICMs), have been proposed to circumvent the main hurdles related to ON delivery. Their unique core/shell structure can protect the ON against premature degradation and the coupling of a ligand on their surface can increase their specificity and internalization. In other systems, a polymer with pH-sensitive properties can be added to facilitate the release of the ON from the endosome and increase its efficiency. The present work was aimed at optimizing ternary PICMs targeted for the delivery of antisens ON. Such systems would provide both cellular internalization of cargo by interaction with receptors on the surface of cell membranes and escape from the endosome through a mechanism of destabilization of the endosomal membrane. PICMs composed of cationic copolymers of poly(ethylene glycol)-bloc-poly((alkylamino)ethyl methacrylate) with a methacrylic acid copolymer adjuvant were prepared. Their physicochemical properties suggest that efficient complexation of nucleic acids was obtained, regardless of the nature of the cationic polymer and the nature of the nucleic acid. Finally, a synthetic approach was developed for the conjugation of an antibody fragment directed against the transferrin receptor via a labile disulfide bond at the end of the cationic copolymer. In conclusion, the work presented herein displays the versatility and potential of ternary PICMs as vehicles for the delivery of ONs and also provides a method for the conjugation of a ligand to generate targeted ternary PICMs.
Bhat, Shreedhar. "Soft Materials Derived From Bile Acid Analogues." Thesis, 2007. http://hdl.handle.net/2005/483.
Full textFALSINI, SARA. "Development of new therapeutic strategies for hERG targeting in leukemia cells." Doctoral thesis, 2014. http://hdl.handle.net/2158/850296.
Full textDufresne, Marie-Hélène. "Mise au point de micelles polyioniques pour l'administration de biomacromolécules thérapeutiques : synthèse de polymères et études physicochimiques." Thèse, 2008. http://hdl.handle.net/1866/6649.
Full textCASHIN, PATRICK. "Sulfonamide Partitioning to Aqueous Cationic Micellar Systems." Thesis, 2011. http://hdl.handle.net/1974/6291.
Full textThesis (Master, Chemistry) -- Queen's University, 2011-01-31 09:46:28.248
Wang, MeiHui, and 王美惠. "Regeneration Cationic Surfactant in Micellar-Enhanced Ultrafiltration System." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/75176096972777344506.
Full text國立屏東科技大學
環境工程與科學系
88
Removal of dissolved low-molecular-weight organics and multivalent metal ions from wastewater is not efficient by conventional separation techniques such as distillation and adsorption process. Micellar-enhanced ultrafiltration (MEUF) system has been successfully applied as a technique for removing dissolved contaminants from aqueous streams and for surfactant soil washing process. Regeneration of surfactant from this separation processes are economically attractive by reducing raw material costs. Therefore, it is important to recover surfactant from MEUF process. The objective of this study is to understand the binding behaviors between surfactant and contaminants and to study how to utilize a simple physichemical method to separate surfactant from pollutants (chromate or phenol). Then the process feasibility of the combination of both membrane separation system and surfactant regeneration system were evaluated by reusing the surfactant, metal, organics, and product water. Precipitation method was utilized to recover cationic surfactant from pollutants. Two processes were used in this study. Firstly, salts such as calcium chloride, iron chloride, barium chloride was added to react with chromate and form insoluble precipitates. Secondly ions which had opposite charge (counter ion) were added to the surfactant because of the low solubility of surfactant-iodine complex. Redissolution of surfactant back into water is an important step before it can be recycled and reused. One way to accomplish this goal is to introduce co-ion(ions with the same charge as the counter ion) which tends to precipitate with the counter ion preferentially to the surfactant ion. This research included two sections:the first section is to construct a batch experiments to determine the type and optimal ratio of precipitation agents, counter ion and co-ion. The second section is to combine the membrane separation system with surfactant recovery system. The results showed that:(1)the molar ratio of precipitation agents and chromate greater than 2, the regeneration ratio of surfactant was greater than 70% ;(2)the molar ratio of counter ion and chromate greater than 1.25, the molar ratio of co-ion and CPC greater than 1.5, the regeneration ratio of surfactant was around 50% ;(3)the molar ratio of counter ion and phenol greater than 1, co-ion and CPC molar ratio greater than 0.5, the regeneration ratio of surfactant was around 50% ;(4)regenerated surfactant still had the capacity to adsorb contaminants.
陳惠美. "Studies of the Preparation and Characterization of Cationic Polymeric-Micelle." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/83ecst.
Full textChung, Zen-Hung, and 鍾仁宏. "Preparation of Cationic PLGA Micelle Conjugated with Polyurethane Dendrimer for Delivery of DNA." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/xqg826.
Full text嘉南藥理大學
生物科技系
103
Gene therapies using DNA and siRNA have been widely investigated in fundamental research. There are many methods to increase the transfection and gene expression including viral and non-viral vectors. Due to many drawbacks of viral vectors, non-viral carriers became another choice for gene therapy. Generally, the polymeric micelles were usually composed of amphiphilic block copolymers. The research was designed to use polyurethane dendrimers(PUAD) as a hydrophilic periphery. Because of the dendrimers with cationic characteristic, therefore, we conduct some test on the polymeric micelles to make sure that their potential to be a transfection vector. Biodegradable material poly(D,L-lactide-co-glycolide)(PLGA) was used as a inter hydrophobic core and reduced the toxicity of cationic PUAD. In this study, we used different generations of PUAD (G 2.0, 3.0) and PLGA to form amphiphilic block copolymers by dehydration reaction and their chemical structures were confirmed using FT-IR and NMR. The following tests were to evaluate the characteristics of PLGA-PUAD micelles: DLS to analyze its particle size and zeta-potential, electrophoresis, cytotoxicity, and transfection efficiency. It was found that the PUAD-PLGA can become a potential non-viral gene vectors based on the above results.