Dissertations / Theses on the topic 'Catarrhalis'
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Enright, Mark Charles. "Molecular characterization of Moraxella catarrhalis." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158242.
Full textGill, Lyndell R. "Moraxella (Branhamella) Catarrhalis: A Molecular Epidemiology Study." Digital Commons @ East Tennessee State University, 1995. https://dc.etsu.edu/etd/2684.
Full textBullard, Brian. "Characterization of the Moraxella catarrhalis Hag Adhesin." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1195596894.
Full textStawska, Agnieszka A. "Purification of Aspartate Transcarbamoylase from Moraxella (Branhamella) catarrhalis." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2864/.
Full textAttia, Ahmed Sherif. "The USPA2 protein and serum resistance of Moraxella Catarrhalis." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=145.
Full textFowler, Michael A. (Michael Allen) 1961. "Characterization of Aspartate Transcarbamoylase and Dihydroorotase in Moraxella Catarrhalis." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc277709/.
Full textBowman, Melissa Lynne. "Biochemical characterization of Moraxella catarrhalis strains associated with Otitis media." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/25397.
Full textEaston, Donna Meredith, and n/a. "Functional and Antigenic Characterisation of the Moraxella catarrhalis protein M35." University of Canberra. n/a, 2008. http://erl.canberra.edu.au./public/adt-AUC20081217.083105.
Full textJonatat, Carola [Verfasser]. "Die Aktivierung des humanen Bronchialepithels durch Moraxella catarrhalis / Carola Jonatat." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023464616/34.
Full textYeo, Siew-Fah. "Epidemiology and antimicrobial resistance of Haemophilus influenzae and Moraxella catarrhalis." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309743.
Full textNguyen, Kim Thuy. "Construction of a Physical Map of Moraxella (Branhamella) catarrhalis Strain ATCC25238." Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc279104/.
Full textVigelahn, Manuel [Verfasser]. "Molekulare Mechanismen der Moraxella catarrhalis induzierten Apoptose pulmonaler Epithelzellen / Manuel Vigelahn." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1079524452/34.
Full textCampbell, Sara J. "Mechanisms of Moraxella catarrhalis Induced Immune Signaling in the Pulmonary Epithelium." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1268141520.
Full textAkimana, Christine. "Structural and Functional Analysis of Moraxella catarrhalis Adhesins MCAP and OMPCD." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1180025995.
Full textSlevogt, Hortense Gisela [Verfasser]. "Molekulare Mechanismen der Interaktion von Moraxella catarrhalis mit pulmonalen Epithelzellen / Hortense Gisela Slevogt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023783436/34.
Full textChen, Miao. "Moraxella catarrhalis-induced innate immune responses in human pulmonary epithelial cells and monocytes." Toledo, Ohio : University of Toledo, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1260375737.
Full text["In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences."] Title from title page of PDF document. Bibliography: p. 80-112.
Heinrich, Annina. "Die Bedeutung von CEACAM3 für die Moraxella catarrhalis induzierte Aktivierung von humanen Granulozyten." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/18831.
Full textThe chronic obstructive pulmonary disease (COPD) is the fourth most common cause of death worldwide. 25 % of the acute bacterial exacerbations are caused by infection with the human restricted pathogen Moraxella catharralis. Both the acute and the chronic inflammatory stage of COPD are predominantly determined by neutrophil granulocytes in the respiratory tract, which in addition to antimicrobial effector functions can also regulate the inflammation or immune response by releasing cytokines. This work investigated if the interaction of M. catarrhalis with the human granulocyte-specific receptor carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 3 leads to an activation of the neutrophil granulocytes and to a NF-kappaB-dependent chemokine production. Primary granulocytes from healthy donors as well as NB4 cells were infected with M. catarrhalis in the presence of various inhibitors, siRNA or CEACAM-blocking antibodies, and then chemokine secretion was determined by ELISA. Using a luciferase reporter gene assay and chromatin immunoprecipitation, activation of the transcription factor NF-kappaB was investigated. In this work it could be shown that the specific interaction of CEACAM3 with M. catarrhalis UspA1 results in the activation of neutrophil granulocytes. Furthermore, there is a CEACAM3-UspA1-dependent activation of the transcription factor NF-kappaB and increased secretion of proinflammatory chemokines. NF-kappaB activation is dependent on the phosphorylation of the CEACAM3 ITAM-like motif and occurs via the Syk and Card9 signaling pathways. The results suggest that neutrophil granulocytes are able to specifically modulate M. catarrhalis induced airway inflammation in COPD via the surface receptor CEACAM3.
Serrano, Aybar Pablo. "Mechanisms of induction of CCL20/MIP3-α in lung epithelial cells by Moraxella catarrhalis." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1222875028.
Full textCumbes, Bevan Christopher. "Responses of the Opportunistic Pathogen Moraxella (Branhamella) catarrhalis to Clinically Relevant Changes in Environmental Conditions." Thesis, University of the West of England, Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524691.
Full textZabel, Solveig. "Die Bedeutung von CEACAM1 für die Moraxella-catarrhalis-induzierte TLR2-vermittelte Aktivierung des respiratorischen Epithels /." Berlin : Mbv, Mensch- & -Buch-Verl, 2009. http://d-nb.info/998778087/04.
Full textJAGER, BEAUVEIL AURELIE. "Activite in vitro comparee de differents antibiotiques vis-a-vis de streptococcus pneumoniae, haemophilus influenzae et moraxella catarrhalis : enquete epidemiologique au c.h.r. de metz au cours de l'annee 1990." Nancy 1, 1993. http://www.theses.fr/1993NAN1A202.
Full textZabel, Solveig [Verfasser]. "Die Bedeutung von CEACAM1 für die Moraxella catarrhalis-induzierte TLR2-vermittelte Aktivierung des respiratorischen Epithels / Solveig Zabel." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/1024004317/34.
Full textCarbonneau, Julie. "Caractérisation de la réponse immune naturellement acquise chez l'homme au cours de la colonisation avec Moraxella (Branhamella) catarrhalis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0004/MQ43791.pdf.
Full textZahradnik, Sabrina [Verfasser]. "Die M. catarrhalis – induzierte Verminderung viraler Rezeptoren und deren Bedeutung für die antivirale Immunantwort in pulmonalem Epithel / Sabrina Zahradnik." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1048047431/34.
Full textWestman, Eva. "Experimental acute otitis media : aspects on treatment, protection and structural changes." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162.
Full textTaylor, LaShan Denise. "Antibiotic Resistance: Multi-Drug Profiles and Genetic Determinants." [Johnson City, Tenn. : East Tennessee State University], 2001. http://etd-submit.etsu.edu/etd/theses/available/etd-1210101-134219/unrestricted/taylorl121101a.pdf.
Full textSteiner, Tamara Alice [Verfasser]. "Die Bedeutung des humanen β-Defensin-3 für die Infektion von humanem respiratorischem Epithel mit Moraxella catarrhalis / Tamara Alice Steiner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052221475/34.
Full textBeeck, Andreas. "Molekularepidemiologische Charakterisierung der BRO-[beta]-Laktamasen [BRO-beta-Laktamasen] europäischer Moraxella catarrhalis Isolate und Analyse der In-vitro-Aktivität verschiedener Antibiotika." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971101582.
Full textBalder, Rachel. "Type V Secretion System Exoproteins and their Roles in the Adherence of the Gram-Negative Bacterial Pathogens Moraxella catarrhalis, Burkholderia pseudomallei and Burkholderia mallei." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1188909479.
Full textUskudar, Guclu Aylin. "Identification Of Streptococcus Pneumoniae, Haemophilus Influenzae, And Moraxella Catarrhalis From Sputum Samples Of Patients With Community Acquired Pneumonia By Polymerase Chain Reaction." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12605920/index.pdf.
Full textStreptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis from sputum of patients with community acquired pneumonia admitted to The Department of Pulmonary Diseases of Gulhane Military Medical Academy. In this study, 107 sputa from 142 patients with suspected community acquired pneumonia were used to survey the causative agents. Identification of the pathogens was performed by sputum Gram stain and conventional microbiological methods. Polymerase chain reaction was performed to investigate the presence of S.pneumoniae, H.influenzae, and M.catarrhalis for the same sputum samples as well. PCR products were processed by electrophoresis on 2% agarose gels with visualization of the amplicon with ethidium bromide and UV illumination. The 33 of 107 samples were positive in cultures and 67 in PCR. S.pneumoniae (48.5%) was the most common etiologic agent as to PCR analysis. The incidences of H.influenzae and M.catarrhalis were determined as 18.6%, and 4.7% respectively. The incidence of S.pneumoniae in patients with CAP and control group individuals were almost the same. The sputum PCR positives were higher than those reported carriage rates for these three microorganisms. 9 of 107 patients with PCR-positive had evidence of infection with pathogens other than S.pneumoniae. The results indicated that some of the PCR results were false positive due to oropharyngeal contamination. PCR testing of sputum samples for diagnosing pneumococcal pneumonia is unable to distinguish colonization from infection in some circumstances. To distinguish the colonization from infection, sputum Gram stain should be applied to the sputum specimens. Because of being faster and easier, PCR looks like becoming more reliable technique by the using of valid specimens from patients with community-acquired pneumonia if supported by quantitative techniques.
Heinrich, Annina [Verfasser], Arturo [Gutachter] Zychlinsky, Hortense [Gutachter] Slevogt, and Ralf [Gutachter] Schumann. "Die Bedeutung von CEACAM3 für die Moraxella catarrhalis induzierte Aktivierung von humanen Granulozyten / Annina Heinrich ; Gutachter: Arturo Zychlinsky, Hortense Slevogt, Ralf Schumann." Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1185495614/34.
Full textBergström, Jennie. "Nested PCR for distinguishing Haemophilus haemolyticus from Haemophilus influenzae and Cloning and expression of fragmented Moraxella catarrhalis IgD-binding protein in E. coli." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8014.
Full textABSTRACT
Nontypable Haemophilus influenzae is a common cause of otitis, sinusitis and conjunctivitis. It is the most common bacterial pathogen associated with chronic obstructive pulmonary disease (COPD). Studies have shown that nonpathogenic Haemophilus haemolyticus are often mistaken for Haemophilus influenzae due to an absent hemolytic reaction on blood agar. Distinguishing H. haemolyticus from H. influenzae is important to prevent unnecessary antibiotic use, and to understand the role of H. influenzae in clinical infections. In this study, PCR-primers for amplifying 16S rDNA sequences were used to set up a method for distinguishing H. haemolyticus from H. influenzae. The aim was to use the method for analyzing apparent H. influenzae strains, to investigate if some strains were in fact H. haemolyticus. However, because of problems with unspecific primerannealing,no conclusions could be drawn regarding misclassification of H. haemolyticus.
Moraxella catarrhalis is the second most common bacterial pathogen associated with COPD. It also causes otitis and sinusitis. An important virulence factor of M. catarrhalis is the outer membrane protein Moraxella catarrhalis IgD-binding protein (MID). One part of the protein; MID764-913 , has been shown to function as an adhesin, and this part has been fragmented to further investigate its adhesive properties. The aim of this second, independent study, was to express some of these proteinfragments by cloning in E. coli. The time spent on this project was too short, and no proteins could be expressed duing this period.
Tiwari, Krishna Nand [Verfasser]. "Vergleich unterschiedlicher Methoden zur Quantifizierung der Adhäsion von Moraxella catarrhalis an pulmonalen Epithelzellen und Etablierung eines neuen Fluoreszenz-basierten Adhäsionsassays / Krishna Nand Tiwari." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1027814549/34.
Full textAlnahas, Safa [Verfasser], and Ulrich [Akademischer Betreuer] Steinhoff. "IL-17 and TNF-alpha are essential mediators of M. catarrhalis triggered exacerbation of HDM allergic airway inflammation / Safa Alnahas ; Betreuer: Ulrich Steinhoff." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1137323345/34.
Full textQaiem, Maqami Lily [Verfasser]. "Die Bedeutung der Protein-Kinase C und ihrer Isoformen für die Moraxella catarrhalis induzierte IL-8-Sekretion in humanem pulmonalen Epithel / Lily Qaiem Maqami." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1025239954/34.
Full textErman, Evelina. "Analys av antikroppar mot Moraxella catarrhalis hos patienter med multipelt myelom, Waldenströms makroglobulinemi och monoklonal gammopati av oklar signifikans med ”enzyme-linked immunosorbent assay”." Thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-8301.
Full textAl-Saadi, M. H. "Pathogenesis of malignant catarrhal fever in cattle." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3025852/.
Full textSharp, Colin Peter. "The molecular basis of malignant catarrhal fever." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29991.
Full textSwa, Sandi. "Large granular lymphocyte dysregulation in malignant catarrhal fever." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/30020.
Full textEsnault, Olivier Bertagnoli Stéphane. "Étude sur l'analyse de risque de la Fièvre Catarrhale Ovine (Bluetongue) dans le bassin ovin laitier de Roquefort cas particulier des centres d'insémination artificielle /." [S.l.] : [s.n.], 2008. http://oatao.univ-toulouse.fr/2086/1/debouch_2086.pdf.
Full textHemati, Behzad. "Interactions entre le virus Bluetongue et cellules dendritiques lymphatiques du mouton." Versailles-St Quentin en Yvelines, 2008. http://www.theses.fr/2008VERS0051.
Full textBluetongue virus (BTV), an orbivirus of the reoviridae family comprises 24 serotypes and is responsible for an insect transmitted hemorrhagic disease in ruminants that generates important economic losses all over the world. The severity of the BTV induced syndrome as well as the duration of viraemia greatly varies between BTV serotypes and hosts. The innate response to the virus could be involved in host sensitivity and has not been studied. We investigated the first steps of BTV dissemination and type I IFN response in the afferent lymphatic in sheep, right after intra-cutaneous delivery of the virus. We showed that BTV initially migrates in the skin draining lymph mainly associated to conventional dendritic cells (cDC). Lymph cDC supported BTV RNA, protein and infectious virus production of several serotypes, independently of viral attenuation. BTV expression in cDC did not impair their survival but rather favored it. Interaction of BTV with cDC preparation resulted in an increased expression of CD80 and CD86 as well as an increase in IL12, IL1b and IL6 mRNA expression. Finally lymph cDC cultured with BTV triggered stimulation of specific CD4 and CD8 T cell proliferation as well as IFNg production. BTV thus utilizes cDC for its first lymph dissemination step in the host without altering their classical immune function of antigen presentation, reflecting an optimal adaptation of the virus to its first cell target. Besides, we found that type I IFN is detectable in 2 peaks (24 hours and day 5 - 6) in afferent lymph in parallel to the viral dissemination. Only lymph plasmacytoid (pDC) and not cDC were producing type I IFN (IFNa) to BTV, independently on viral serotype, on viral replication and on endosomal acidification. Collectively these finding suggest the hypothesis that BTV replication in cDC and/or cDC and pDC responses might be involved in inter-individual susceptibility to BTV
Lankester, Felix John. "The impact and control of malignant catarrhal fever in Tanzania." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7769/.
Full textKumati, Osama B. Mohamed. "Virus life cycle and the parthenogenesis of malignant catarrhal fever." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38034/.
Full textSchock, Alexandra. "Characterisation of the T-cell proliferation in malignant catarrhal fever." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/29987.
Full textChauveau, Emilie. "Etude des mécanismes d'induction et de contrôle de la production d'interféron par le virus de la Bluetongue dans les cellules non-hématopoïétiques." Paris 7, 2012. http://www.theses.fr/2012PA077235.
Full textBluetongue disease is a severe hemorragic disease in ruminant, transmitted by midges from the genus Culicoides. Bluetongue virus (BTV) is the etiologic agent of the disease. This double stranded RNA (dsRNA) virus is an Orbivirus, belonging to the Reoviridae family. It has been reported for a long time that BTV infection induces interferon production. However the cellular sensors and signaling pathways involved in this process remain unknown. The aim of this project is to identify them and to evaluate the capacity of BTV to modulate type I IFN (IFN-I) synthesis, as other viruses do. As expected, in response to BTV infection, human and bovine cells showed a strong production of IFN[3. This production is dependent on viral replication and mediated through the RNA helicases, RIG-I or MDA5. These RNA helicases can activate IFNO production by sensing the dsRNA of BTV in a human cellular model. This antiviral response leads to the control of BTV replication. Furthermore, we found that BTV serotype 8 (BTV-8) can dampen the IFN-I pathway and that the non structural protein 3 (NS3) is involved in this process. NS3 specifically inhibits the transcripts production activated by the IFN-I production pathway. NS3 seems to target a protein involved in the RIG¬like receptor (RLR) pathway between MAVS and TBKVIKKe complex, but its mechanism of action remains to determine
Perrin, Aurélie Anne. "Contribution au développement de vaccins capripoxviraux recombinants contre la fièvre catarrhale ovine." Montpellier 2, 2007. http://www.theses.fr/2007MON20134.
Full textCourtejoie, Noémie. "Modélisation de la dynamique et du contrôle de la fièvre catarrhale ovine en France." Thesis, Paris Est, 2019. http://www.theses.fr/2019PESC0013.
Full textBluetongue virus serotype 8 (BTV-8) spread throughout France in 2007/09 and had a strong economic impact. Vaccination, first mandatory then voluntary, allowed regaining a disease-free status in December 2012, but a new outbreak occurred in August 2015. BTV-8 may have kept circulating all along. The aim of this thesis was to clarify the epidemiology of BTV-8 from emergence to re-emergence and to provide a critical analysis of surveillance and control measures, using various modelling tools. Using risk factor analyses, we characterized the immunity of cattle at the time of re-emergence and detected low-level BTV-8 circulation prior to that date. Using catalytic models developed in a Bayesian context, we added a time dimension, we separated the contribution of seroconversion mechanisms (infection and vaccination) and transmission mechanisms (vector-borne and transplacental), we estimated the burden of infection and the probability of vertical transmission (> 50% in 2016), and we assessed the coverage of voluntary vaccination (poorly implemented in 2011/12, with regional contrasts). We synthesized all available information and developed a mathematical, dynamic and stochastic model, using contact networks to represent different types of host and vector movements. We identified the control measures that had been effective (mandatory vaccination, trade restrictions), and suggested alternative ones (targeting emergency vaccination ahead of the front, controlling movements on pastures). Finally, we provided arguments in favor of a continuous and undetected BTV-8 circulation
Villard, Pierre. "Évaluation de l'impact et de l'efficacité de la surveillance et de la lutte de la fièvre catarrhale ovine en France." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1351.
Full textBluetongue virus (BTV) serotype 8 had a strong economic impact on the cattle industry during the epizootic between 2006 and 2009 in France. This thesis aimed to evaluate the financial impact of BTV diffusion after its re-emergence in 2015, and to bring new insights into the dynamics of Culicoides, and the surveillance and control system. By collecting and analyzing data, we were able to calculate the cost of surveillance system from September 2015 to December 2016 (€ 14.6 million excluding taxes). Thanks to the analysis of historical data on cattle movements, we were able to highlight changes in movement dynamics for farms according to their health status, as well as to estimate excess bovine mortality related to the circulation of BTV. By using catch data from Culicoides, we were able to establish a model for predicting the abundance of these vectors, validating at the same time the use of vector zones in entomological surveillance. We finally used an existing model to highlight results disparity according to several surveillance and control system against BTV. We have established that programmed surveillance does not provide relevant efficiency in the context of detecting a high-impact disease such as BTV, while movement restriction measures play an essential role in the preservation of the cattle industry against the BTV
Bouet-Cararo, Coraline. "Evaluation d'un vaccin recombinant dérivé d'adénovirus canin chez le mouton : application à la fièvre catarrhale ovine (FCO)." Paris 11, 2010. http://www.theses.fr/2010PA114846.
Full textBluetongue is a viral disease that affects Ruminants. Present vaccines (which are attenuated or inactivated vaccines) do not achieve complete cross protection against the 24 serotypes of the Bluetongue Virus (BTV). During this thesis different recombinant vaccines derived from the canine type 2 adenovirus have been developed to afford a broad protection in sheep against BTV
Levy, Claire Safrai. "Identification and characterization of ovine herpesvirus 2 microRNAs." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6468.
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