Dissertations / Theses on the topic 'Castlemaine'
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Hargreaves, Joan Mildred, and joan hargeaves@deakin edu au. "Tariff protection and politics: Castlemaine 1870-1901." Deakin University. School of Australian and International Studies, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20071012.152659.
Full textAstruc, Marie-Pierre. "Maladie de Castleman : revue de la litterature, à propos d'une observation." Montpellier 1, 1990. http://www.theses.fr/1990MON11293.
Full textBerger, Françoise. "L'hyperplasie lymphoide angio-folliculaire : syndrome(s) ou maladie(s) ; six observations recentes confrontees aux donnees de la litterature." Saint-Etienne, 1989. http://www.theses.fr/1989STET6202.
Full textGOUZENES, STEPHANE. "A propos d'un cas de la maladie de castleman de type plasmocytaire." Toulouse 3, 1991. http://www.theses.fr/1991TOU31093.
Full textHamidou, Mohamed. "L'hyperplasie lymphoide angiofolliculaire de castleman : etude anatomo-clinique et revue de la litterature." Toulouse 3, 1991. http://www.theses.fr/1991TOU31546.
Full textRENAUDEAU, SYLVIE. "Les pseudo-tumeurs de castleman : diagnostic des formes abdominales, a propos d'une observation." Nantes, 1990. http://www.theses.fr/1990NANT015M.
Full textGaspard, Catherine. "Hyperplasie angiofolliculaire ou maladie de Castelman : étude anatomo-clinique de 10 cas et revue de la littérature." Montpellier 1, 1996. http://www.theses.fr/1996MON11063.
Full textPHILIBERT, PATRICK. "Sarcome de kaposi extensif au cours d'un deficit immunitaire acquis en dehors de toute greffe d'organe et d'infection par le virus de l'immuno-deficience humaine : a propos d'une observation de maladie de castleman." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20408.
Full textChetty, Dharshnee Rama. "Interaction between DC-SIGN and DC-SIGNR with HHV-8 (LANA-1) and HIV-p24 in Castleman disease." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29653.
Full textKy, Tchouan. "Maladie de Castleman à forme multicentrique avec transformation monoclonale : étude à partir d'une observation et revue de la littérature." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M048.
Full textSbihi, Zineb. "Immunopathologie de la Maladie de Castleman Multicentrique associée à l'infection par HHV-8. Altérations des Cellules iNKT et Lymphocytes B." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066221/document.
Full textHuman Herpesvirus-8 is a B-lymphotropic \γ-herpesvirus closely related to the Epstein-Barr virus (EBV). He is specifically associated with monotypic (IgM/λ) plasmablasts in Multicentric Castleman disease (HHV-8 MCD), which is a B lymphoproliferative disorder. These cells express transcription factors suggesting they are at the plasmablast or pre-pasma cell stage of differentiation. Invariant natural killer T (iNKT) cells are innate-like T cells that play a role in antiviral immunity, specifically in controlling viral replication in EBV-infected B cells. Decline of iNKT cells is associated with age or HIV infection, both situations associated with HHV-8-related diseases. We demonstrated that iNKT cell abnormalities are associated with HHV-8 MCD. These iNKT cell alterations were found to be associated with an imbalance in the frequency of circulating and splenic B cell subsets, and results of Coculturing experiments indicate that iNKT cells may be required for maintaining this cell population. In the second part of our work thesis, we demonstrate that HHV-8 MCD is associated with a unique population of circulating plasmablasts detected during the flare of the disease, with the typical phenotype of the MCD HHV-8-infected plasmablasts in MCD lesions. Then, we used gene expression profile analysis (about 48 000 genes) to further define the phenotype of this MCD HHV-8-infected cells and to investigate the lymphoma relationship to normal B cell subpopulations. The results showed that MCD HHV-8-infected cells displayed a common gene expression profile that is clearly distinct from all the normal B cell subpopulations. The gene expression profile of MCD HHV-8-infected cells was defined as plasmablastic. Moreover, the transcriptomic pattern of MCD HHV-8-infected cells demonstrates that these cells are proliferating and escaping the immune system. Finally, we determined the clonality and the cellular origin of the monotypic circulating plasmablasts by studying the rearranged immunoglobulin heavy genes in LANA+ HHV-8-infected B cells from patients with HHV-8 MCD. Our results show that these cells are polyclonal without somatic mutation. Altogether our results allowed us to elaborate a model of MCD physiopathology
Salas, Joel. "La maladie de castleman en o. R. L. Et chirurgie cervico-faciale : a propos d'une masse parapharyngee ; revue de la litterature." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13808.
Full textCouty, Jean-Pierre. "Aspects moléculaires de l'infection par l'herpèsvirus humain de type 8 (hhv-8/kshv)." Limoges, 1999. http://www.theses.fr/1999LIMO104A.
Full textBeardmore, Carol. "The rural community through the eyes of the land agent on the Marquis of Anglesey's Dorset and Somerset Estate : William Castleman and his sons c1812-1854." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/36702.
Full textCormier, Jean-Grégory. "Génomique fonctionnelle du complexe majeur d'histocompatibilité dans la myasthènie auto-immune avec hyperplasie folliculaire du thymus." Paris 5, 2011. http://www.theses.fr/2011PA05T012.
Full textAutoimmune myasthenia gravis (MG) is characterized by muscular weakness due to autoantibodies targeting the acetylcholine receptor (AChR). This complex disorder is heterogeneous, its more common form associating a thymic follicular hyperplasia (TFH). The major histocompatibility complex (MHC) plays a predominant part in the genetic component of this form, with the association of the 8. 1 haplotype (HLA-A1-B8-DR3). Using microsatellites (STR), the laboratory had undertaken a detailed description of the effects of this haplotype. However, this haplotype explains only partly the impact of MHC on the risk of developing the disease. The goal of my work was to identify new MHC alleles influencing MG with TFH or the autoantibody titer. A first approach focusing on the distal class I region combining STR and SNPs has delineated two protective haplotypes around the HLA-F and ZNRD1-AS1 loci as well as a predisposing haplotype including the RNF39 gene. A re-sequencing study of the class III candidate gene, NCR3, has then revealed an accumulation in the patients group of rare variants, including three coding mutations. Finally, a SNP-based fine mapping of the entire MHC has shown an association between MG with TFH and non 8. 1 alleles around the TAPBP locus, in the extended class II region, and also an influence of non 8. 1 alleles at the border of class II and III regions on the anti-AChR autoantibody titers. Hence, although functional variants remain to be identify, overall our work provides a better understanding of the complex role of the MHC in MG with TFH
Ferreira, Pedro Rafael Neves. "Síndrome de POEMS associado a doença de Castleman : a case report." Master's thesis, 2017. http://hdl.handle.net/10451/35213.
Full textO Síndrome de POEMS é uma entidade clínica rara, de índole paraneoplásica, cujo acrónimo representa as suas principais manifestações – polineuropatia (P), organonomegália (O), endocrinopatia (E), gamapatia monoclonal (M), alterações da pele (S). A sua fisiopatologia é intrincada e carece ainda de investigação, assumindo-se no entanto que o Fator de Crescimento Endotelial Vascular (VEGF), em conjunto com os seus co-indutores, seja responsável pelas manifestações cardinais. Por se tratar de uma patologia rara e com uma vasta panóplia de sinais/sintomas que podem mimificar outras patologias mais frequentes, o seu diagnóstico é frequentemente tardio e exige um elevado nível de suspeição clínica. Estima-se que cerca de 11-30% dos doentes com Síndrome de POEMS exibam concomitantemente Doença de Castleman (DC). Dado que existe partilha de vias fisiopatológicas, principalmente ao nível da produção de IL-6 e VEGF, foi proposto um sinergismo entre ambas as patologias. O presente Case Report descreve um quadro clássico de Síndrome de POEMS, associado a DC, sendo ilustrativo da complexidade diagnóstica e raridade destas duas patologias.
POEMS syndrome is a rare parenoplasic syndrome, whose acronym stands for the main manifestations - polyneuropathy (P), organomegaly (O), endocrinopathy (E), monoclonal gammopathy (M) and skin abnormalities (S). Its pathophysiology is intricate and still requires investigation. However, it is assumed that the Vascular Endothelial Growth Factor (VEGF), together with its co-inducers, is responsible for the cardinal manifestations. Due to its rarity and multiplicity of symptoms that mimic other more frequent pathologies, POEMS is frequently a late diagnosis, requiring high levels of clinical suspicion. It is estimated that about 11-30% of patients with POEMS syndrome, exhibit concomitant Castleman Disease (CD). Since POEMS syndrome and CD share pathophysiological features, mainly regarding VEGF and IL-6 production, a synergism is proposed between these diseases. This case report describes a classic POEMS syndrome, associated with Castleman's disease, emphasizing the rarity and diagnostic complexity of these pathologies.
Faustino, Iolanda Vicente. "Doença de Castleman multicêntrica : as dificuldades no diagnóstico de uma doença rara e heterogénea." Master's thesis, 2018. http://hdl.handle.net/10451/42221.
Full textA doença de Castleman é uma doença linfoproliferativa benigna rara que abrange todos os grupos etários. A forma multicêntrica apresenta uma heterogeneidade de manifestações clínicas e tem um mau prognóstico. O presente trabalho faz uma revisão da literatura da doença de Castleman multicêntrica idiopática, havendo uma focalização na vertente diagnóstica. Verifico que a confirmação histológica por biópsia ganglionar é um dos parâmetros obrigatórios e que a PET-TC é o método imagiológico mais sensível. A semiologia e as alterações laboratoriais são variáveis e coincidentes com um estado inflamatório sistémico. A ausência de hipergamaglobulinémia associada a trombocitopenia constituem sinais de alerta para a pesquisa da síndrome TAFRO (do inglês Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis, Organomegaly), variante mais grave da doença. Os principais diagnósticos diferenciais da doença de Castleman multicêntrica são as neoplasias, tais como: linfomas, mieloma múltiplo, síndrome POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes), as doenças auto-imunes do tecido conjuntivo e as infeções, sobretudo o herpes vírus humano 8. De modo a facilitar a abordagem diagnóstica, proponho uma tabela onde se encontram descriminados os parâmetros a avaliar na biópsia ganglionar que devem ser completados com outros exames. Concluo que para o futuro é necessário: a existência de informação agregada facilmente disponível para a comunidade médica, assim como, o estabelecimento de critérios universais de gravidade e de protocolos de seguimento.
Castleman’s disease is a rare benign lymphoproliferative disease that can occur in individuals of all ages. The multicentric subtype has very heterogeneous clinical manifestations and is associated with a poor prognosis. This thesis aims to survey the literature in the field of idiopathic multicentric Castleman’s disease, focusing mainly on the diagnosis. It has been ascertained that the histological confirmation (which falls back on biopsies) is compulsory and that the PET-CT scan is the most sensitive imaging method. The semiology and laboratorial alterations are variable and coincident with a systemic inflammatory state. The absence of hypergammaglobulinemia associated with thrombocytopenia are red flags that determine the investigation of TAFRO (Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis, Organomegaly), most severe subtype of the disease. The main differential diagnosis are neoplasms, such as: lymphoma, multiple myeloma, POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes), connective tissue autoimmune disease and infections, mostly HHV8. In order to facilitate the diagnostic approach, a table has been proposed, in which all findings that should be evaluated in a lymph node biopsy are listed. These findings will then require additional exams. In conclusion, in the future we will need compiled information that is readily available for the medical community, as well as established universal criteria of disease severity and follow-up guidelines.
Reichenberger, Franziska [Verfasser]. "Genexpressionsmuster und Phänotypisierung der Kaposi-Sarkom Virus-infizierten Zellen beim Morbus Castleman / vorgelegt von Franziska Reichenberger geb. Peitsch." 2010. http://d-nb.info/1010568388/34.
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