Dissertations / Theses: 'Cassina'

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Baccini, Luciene Ruiz [UNESP]. "Obtenção de derivados semissintéticos dos alcalóides (-) - cassina e (-) e espectalina e avaliação do potencial antimalárico." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/97984.

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O projeto temático “Conservação e uso sustentável da diversidade vegetal do Cerrado e Mata Atlântica: diversidade química e prospecção de fármacos potenciais” resultou no estudo químico de várias espécies de plantas e microorganismos, alguns de interesse farmacológico. Da espécie vegetal Senna spectabilis foram isolados vários alcaloides 3-piperidinóis-2,6-dissubstituídos, entre estes (–)-cassina e (–)-espectalina, duas substâncias homólogas de difícil separação, presente em grande quantidade nas flores desta planta, bastante utilizada como ornamental. Os alcaloides piperidínicos (–)-cassina e (–)-espectalina foram selecionados como material de partida para a obtenção de vários derivados semissintéticos, objetivando alguns estudos de Química Medicinal. Durante a pesquisa deste projeto de mestrado, (–)-cassina e (–)-espectalina foram submetidas a uma série de testes preliminares para avaliação da atividade antimalárica. Os ensaios moleculares foram feitos com a cepa 3D7 de Plasmodium falciparum transfectada com a Proteína de Fluorescência Verde (Green Fluorescent Protein - GFP), no Instituto de Biociências USP-SP, sob supervisão da Profª Drª Célia Regina da Silva Garcia, co-orientadora da presente pesquisa. Devido aos resultados positivos apresentados pelos alcaloides naturais, algumas modificações estruturais foram propostas para os compostos, objetivando potencializar a atividade antimalárica detectada nos produtos naturais. Sendo assim, foram planejadas várias esterificações no grupo hidroxílico do carbono na posição três do anel piperidínico destes alcaloides para a obtenção de uma série de derivados semissintéticos (ésteres) para posterior avaliação antimalárica:...
The project Conservation and sustainable use of plant diversity in the Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs allowed the study of various plant and microorganisms species, several of these, of pharmacological interest. From S. spectabilis plant species were isolated various alkaloids 3-piperidinóis-2,6-disubstituted , being (‒)-cassina and (‒)-espectalina, two major homologous, of hard separation, which were chosen as raw material for the obtainment of several semi-synthetic derivatives, useful for further Medicinal Chemistry studies. During the research of this master's project, preliminary tests were carried out with (‒)-cassina and (‒)-espectalina for antimalarial activity. The molecular assays were performed with the 3D7 strain of Plasmodium falciparum transfected with Green Fluorescent Protein (GFP), at Institute of Biosciences University of São Paulo, under the supervision of Professor Dr. Regina Celia Garcia Silva, also a supervisor of this thesis. Due to the positive results for the natural alkaloids in this assay, aroused the interest for set several structural changes in these compounds, aiming to increase the antimalarial activity of the semi-synthetic ester derivatives. Thus, structural changes were made in the carbon hydroxyl group at C-3 of the piperidine ring of these alkaloids: ... (Complete abstract click electronic access below))

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PEREIRA, Rodrigo Machado. "Atividade antiproliferativa dos alcalóides piperidínicos (-)- cassina e (-)-espectalina sobre células de carcinoma hepatocelular humano - HepG2." Universidade Federal de Alfenas, 2016. https://bdtd.unifal-mg.edu.br:8443/handle/tede/791.

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O câncer tem sido apontado como um dos problemas mais críticos encontrados no sistema público de saúde em todo o mundo, além de ser um dos maiores desafios para a medicina deste século. O carcinoma hepatocelular é a segunda maior causa de morte por câncer em todo o mundo e o quinto mais incidente. Infelizmente, a maioria dos pacientes são diagnosticados em estágio avançado, quando as opções de tratamento são apenas paliativas. Dessa forma, torna-se relevante a busca por novas opções terapêuticas mais efetivas para o carcinoma hepatocelular. Neste contexto, as plantas representam uma importante fonte de descoberta de novos compostos com propriedades farmacológicas, incluindo agentes antineoplásicos. O presente trabalho objetivou investigar o potencial antitumoral in vitro dos alcaloides (-)-cassina e (-)-espectalina, os quais são derivados de Senna spectabilis. A viabilidade celular foi determinada por diferentes métodos colorimétricos (MTS e rezasurina) e pelo ensaio de exclusão em azul de tripano. Ensaio clonogênico foi realizado para avaliar a formação de colônias, enquanto a cinética de progressão do ciclo celular foi determinada por citometria de fluxo. O padrão de organização de elementos do citoesqueleto bem como a frequência de mitoses foram analisadas por imunofluorescência. O perfil de expressão foi determinado por qRT-PCR (ciclina D1) e Western blotting (Histona H3 fosforilada, ERK fosforilada e ERK total). Os resultados mostraram que a mistura de alcaloides reduz significativamente a viabilidade celular, contudo o efeito foi dependente da concentração utilizada. A redução na proliferação celular foi decorrente do bloqueio do ciclo celular preferencialmente na transição G1/S. Os eventos moleculares responsáveis pela regulação negativa do ciclo celular, pelo menos em parte, estão relacionados à capacidade dos alcaloides de inibir expressão de ciclina D1 e ativação de ERK, uma proteína da via de MAPKs. Além disso, os alcaloides também foram efetivos em alterar o padrão de organização normal dos filamentos de actina e microtubulos. Portanto, conclui-se que os alcaloides (-)-cassina e (-)-espectalina apresentam atividade antitumoral promissora contra células de carcinoma hepatocelular e sua estrutura química deve ser considerada para futuros estudos anticâncer in vivo.
Cancer is one of the most critical problems of public health in the world and one of the main challenges for medicine in this century. The hepatocellular carcinoma is the second cause of cancer death and the fifth most incident. Unfortunately, most patients are diagnosed at advanced stage, when the treatment options are palliative. Consequently, the search for novel therapeutic options for hepatocellular carcinoma becomes imperative. In the context, the plants represent an important source for discovery of novel compounds with pharmacological potential including antineoplastic agents. Herein, we aimed to investigate in vitro antitumor potential of an alkaloid mixture derived from Senna spectabilis, (–)-cassine and (–)-spectaline. Cell viability was measured by different colorimetric methods (MTS and rezasurin assay) and trypan blue exclusion. Clonogenic formation assay were promoted in order to evaluate colony formation inspection, while cell cycle progression was determined by flow cytometry. Cytoskeleton elements and mitosis frequency were analyzed by immunofluorescence. Gene expression was determined by immunoblot (ERK1, p-ERK and p-histone H3) and qRT-PCR (Cyclin D1). Alkaloid mixture significantly reduced cell viability of cancer cells in a concentration-dependent manner. Cell proliferation reduction occurred by cell cycle arrest mainly in G1/S transition. We demonstrated that antiproliferative potential of the alkaloids is due to, at least in part, down-regulation of cyclin D1 and ERK inactivation, which is a MAPK pathway protein. Alkaloids also drastically altered F-actin and microtubules distribution pattern. (-)-cassine and (-)-spectaline alkaloids have a promise antitumor activity against hepatoma cells and may be considered for further anticancer in vivo studies
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES

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Baccini, Luciene Ruiz. "Obtenção de derivados semissintéticos dos alcalóides (-) - cassina e (-) e espectalina e avaliação do potencial antimalárico /." Araraquara, 2013. http://hdl.handle.net/11449/97984.

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Orientador: Vanderlan da Silva Bolzani
Coorientador: Célia Regina da Silva Garcia
Banca: Maria Claudia Marx Young
Banca: Patricia Sartorelli
Resumo: O projeto temático "Conservação e uso sustentável da diversidade vegetal do Cerrado e Mata Atlântica: diversidade química e prospecção de fármacos potenciais" resultou no estudo químico de várias espécies de plantas e microorganismos, alguns de interesse farmacológico. Da espécie vegetal Senna spectabilis foram isolados vários alcaloides 3-piperidinóis-2,6-dissubstituídos, entre estes (-)-cassina e (-)-espectalina, duas substâncias homólogas de difícil separação, presente em grande quantidade nas flores desta planta, bastante utilizada como ornamental. Os alcaloides piperidínicos (-)-cassina e (-)-espectalina foram selecionados como material de partida para a obtenção de vários derivados semissintéticos, objetivando alguns estudos de Química Medicinal. Durante a pesquisa deste projeto de mestrado, (-)-cassina e (-)-espectalina foram submetidas a uma série de testes preliminares para avaliação da atividade antimalárica. Os ensaios moleculares foram feitos com a cepa 3D7 de Plasmodium falciparum transfectada com a Proteína de Fluorescência Verde (Green Fluorescent Protein - GFP), no Instituto de Biociências USP-SP, sob supervisão da Profª Drª Célia Regina da Silva Garcia, co-orientadora da presente pesquisa. Devido aos resultados positivos apresentados pelos alcaloides naturais, algumas modificações estruturais foram propostas para os compostos, objetivando potencializar a atividade antimalárica detectada nos produtos naturais. Sendo assim, foram planejadas várias esterificações no grupo hidroxílico do carbono na posição três do anel piperidínico destes alcaloides para a obtenção de uma série de derivados semissintéticos (ésteres) para posterior avaliação antimalárica:... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The project "Conservation and sustainable use of plant diversity in the Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs" allowed the study of various plant and microorganisms species, several of these, of pharmacological interest. From S. spectabilis plant species were isolated various alkaloids 3-piperidinóis-2,6-disubstituted , being (‒)-cassina and (‒)-espectalina, two major homologous, of hard separation, which were chosen as raw material for the obtainment of several semi-synthetic derivatives, useful for further Medicinal Chemistry studies. During the research of this master's project, preliminary tests were carried out with (‒)-cassina and (‒)-espectalina for antimalarial activity. The molecular assays were performed with the 3D7 strain of Plasmodium falciparum transfected with Green Fluorescent Protein (GFP), at Institute of Biosciences University of São Paulo, under the supervision of Professor Dr. Regina Celia Garcia Silva, also a supervisor of this thesis. Due to the positive results for the natural alkaloids in this assay, aroused the interest for set several structural changes in these compounds, aiming to increase the antimalarial activity of the semi-synthetic ester derivatives. Thus, structural changes were made in the carbon hydroxyl group at C-3 of the piperidine ring of these alkaloids: ... (Complete abstract click electronic access below))
Mestre

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Küpper, Patrick. "Stereoselektive Totalsynthese verschiedener Cassia- und Microcos-Piperidinderivate Synthese des (-)-Cassins /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=979464587.

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Souza, Lucimara Amélia de. "Estruturas secretoras em espécies de leguminosas da subtribo Cassiinae (Fabaceae, Caesalpinioideae, Cassieae)." Universidade Federal de Minas Gerais, 2014. http://hdl.handle.net/1843/BUOS-9K2GL4.

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Fabaceae (Leguminosae) is considered one of the three major families of Angiospermae, containing 730 genera and 19,500 species of cosmopolitan distribution, being in Brazil, found about 190 genera and 2,100 native species. Several legumes groups have been amended over time, for instance subtribe Cassiinae, which features three genera resulting from dividing Cassia lato sensu rating: Cassia stricto sensu, Senna and Chamaecrista. External and internal secretory structures are widely distributed in Caesalpinioideae, being cited, extrafloral nectaries, mucilage cells, secretory cavities and ducts. The relevance of secretory structures in Cassiinae becomes evident when we see that in phylogenetic analysis: two clades are distinct in Senna based on the presence or absence of extrafloral nectaries. Thus, the present work has the general objective to investigate the occurrence of secretory structures in fruits, seeds and seedlings of Senna and and flowers of Cassia, Chamaecrista and Senna (Fabaceae, Caesalpinioideae). The aim is also to identify the type of secretory structure and infer the presence of these in adaptation of plants to the environment as well as the fruits and seeds protection, providing information that may be useful for the phylogenetic analysis of the group. The receptaculares colleters of Senna macranthera are located at the base of the floral receptacle and present early development and are fully developed and in secretory activity in the final stages of pre-anthesis. Colleters present structure and cellular dynamics compatible with the acidic polysaccharides synthesis of, dictyosomes as producing large amount of vesicles, flaked appearance secretion accumulation in the periplasmic and subcuticular space. At anthesis, the secretory activity ceases and there is early senescence colleters. The pericarpiais colleters of Senna occidentalis match trichomes that are located in the region corresponding to the median of the fruit valves depression; are functional during the period between anthesis and early fruit ripening, when they become senescent. Colleter secretion accumulates in the periplasmatic and subcuticular spaces; subcuticular space secretion overflows to the outside through fissures in the cuticle. Colleters are present in embryos and seedlings of various Senna species are located in the axils of the cotyledons, lateral to the plumule, in the apex of the embryo axis and seedling. Colleters are present in the embryo of the seed prior to dehydration, in the seedling during germination and seedling up to seven days, when they become senescent. The secretion has pectic nature and form a film covering the region of the apex and sides of the embryo and seedling. Floral colleters were observed in all genera of Cassiinae, highlighting their presence in Chamaecrista, in sections Apoucouita, Caliciopses, Chamaecrista and Xerocalyx, and Senna, which were observed in all species, presenting a unique distribution in the subtribe Cassiinae: scattered throughout the floral receptacle. The extrafloral nectaries study of Senna species deserves enphasys to the EFN amount for taxonomy, phylogenetic inferences and especially for his role in the genus Senna dispersal and adaptation to diverse habitats. The presence of colleters has proved to great importance in the genus Senna, is acting in protection against flowers and fruits desiccation in development, or in facilitating seed germination and seedling establishment for several genus species. The presence of this structure in several secretory organs and species of Senna should be explored in future phylogenetic analyzes, with the studies expansion to Cassia and Chamaecrista genera, as was done for the floral colleters, so that these data can contribute to understanding of relationships in subribo Cassiinae.
Fabaceae (Leguminosae) é considerada uma das três maiores famílias de Angiospermae, contendo 730 gêneros e 19.500 espécies de distribuição cosmopolita, sendo no Brasil, encontrados cerca de 190 gêneros nativos e 2.100 espécies. Diversos grupos de leguminosas têm tido sua classificação alterada ao longo do tempo, caso da subtribo Cassiinae, que apresenta três gêneros resultantes da divisão de Cassia lato sensu: Cassia stricto sensu, Chamaecrista e Senna. Estruturas secretoras externas e internas são amplamente distribuídas em Caesalpinioideae, sendo citadas, nectários extraflorais, células mucilaginosas, canais e cavidades secretoras. A relevância das estruturas secretoras em Cassiinae fica patente quando se verifica que, em estudo filogenético, dois grandes clados são distintos em Senna com base na presença ou ausência de nectários extraflorais. Desta forma, o presente trabalho tem por objetivos gerais averiguar a ocorrência de estruturas secretoras em frutos, sementes e plântulas de Senna e e em flores de indivíduos adultos de Cassia, Chamaecrista e Senna (Fabaceae, Caesalpinioideae). Pretende-se, ainda, identificar o tipo de estrutura secretora e inferir acerca da atuação destas na adaptação da planta ao ambiente, bem como na proteção de frutos e sementes, provendo informações que possam ser úteis para as análises filogenéticas do grupo. Os coléteres receptaculares de Senna macranthera localizam-se na base do receptáculo floral e apresentam desenvolvimento precoce, estando completamente desenvolvidos e em atividade secretora nos estágios finais do período de pré-antese. Os coléteres apresentam estrutura e dinâmica celular compatíveis com a síntese de polissacarídeos ácidos, como dictiossomos produzindo grande quantidade de vesículas, acúmulo de secreção de aspecto floculado no espaço periplasmático e subcuticular. Por ocasião da antese, a atividade secretora cessa e observa-se início de senescência dos coléteres. Os coléteres pericarpiais de Senna occidentalis correspondem a tricomas que se localizam na depressão correspondente à região mediana das valvas dos frutos; são funcionais durante o período compreendido entre a antese e o início da maturação dos frutos, quando se tornam senescentes. A secreção dos coléteres se acumula nos espaços periplasmático e subcuticular; do espaço subcuticular a secreção extravasa para o meio externo através de fissuras na cutícula. Os coléteres presentes nos embriões e plântulas de várias espécies de Senna localizam-se nas axilas dos cotilédones, lateralmente à plúmula, no ápice do eixo do embrião e plântula. Os coléteres estão presentes no embrião antes da desidratação da semente, na plântula durante o processo de germinação e em plântulas de até sete dias, quando se tornam senescentes. A secreção tem natureza péctica e forma um filme cobrindo a região apical e as laterais do eixo do embrião e da plântula. Os coléteres florais foram observados em espécies de todos os gêneros de Cassiinae, destacando sua presença em Chamaecrista, nas seções Apoucouita, Caliciopses, Chamaecrista e Xerocalyx e em Senna, onde foram observados em todas as espécies analisadas, apresentando uma distribuição única na subtribo Cassiinae: dispersos pelo receptáculo floral. O estudo dos nectários extraflorais de espécies de Senna merece destaque pelo valor dos NEFs para a taxonomia, inferências filogenéticas e principalmente, pelo seu papel na dispersão e adaptação do gênero Senna aos diversos habitats. A presença de coléteres tem se mostrado de grande importância no gênero Senna, seja atuando na proteção contra dessecação de flores e frutos em fase de desenvolvimento, ou na facilitação da germinação de sementes, e estabelecimento das plântulas de várias espécies do gênero. A presença desta estrutura secretora em vários órgãos e espécies de Senna deve ser explorada no futuro em análises filogenéticas, com a expansão dos estudos para o gênero Cassia e Chamaecrista, tal como foi realizado para os coléteres florais, de modo que estes dados possam colaborar para o entendimento das relações na subribo Cassiinae.

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Mota, Ellori Laíse Silva. "Ecologia populacional de Cassis tuberosa (Mollusca: Cassidae) em habitats costeiros no Nordeste brasileiro." Universidade Estadual da Paraíba, 2014. http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2037.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Of he more than 100,000 species of marine gastropods currently described, at least 60,000 are shelled, which due to its aesthetic value are involved in the international shell trade, which is poorly documented, and mainly, unquantified. The great majority of molluscs species traded for ornamental purposes are gastropods, large species as Cassis tuberosa, which is among the main targets of the ornamental trade. Thus, being a widely exploited species the ecological role of C. tuberosa in marine ecosystems may be compromised by their removal from the environment. In sandy beach environments analyzed in this study, the population of C. tuberosa is structurally young, which to characterize this area as important on the recruitment of this species. In reef areas studied, the gastropod population is predominantly adult, featuring an important area on the development of the specie, which may contribute to the reproductive stage and hence population growth. The absence of C. tuberosa capture both the sandy plain environment and the reefs to justifies the population density of this gastropod that can be consider high in the studied areas. On a conservation perspective, we suggest that the environments analyzed in this study are potential sites for monitoring of natural populations of C. tuberosa and the development of more detailed population and ecological studies that collaborate to the elaboration of management plans for this species.
Das mais de 100.000 espécies de gastrópodes marinhos descritas atualmente, pelo menos 60.000 possuem concha, que devido ao seu valor estético têm movimentado um comércio internacional ainda pouco documentado, e, sobretudo, pouco quantificado. A grande maioria das espécies de moluscos comercializadas para fins ornamentais são gastrópodes e entre estes, espécies de grande porte como Cassis tuberosa, que está entre os principais alvos do comércio ornamental. Assim, por ser uma espécie amplamente explorada o papel ecológico de C. tuberosa nos ecossistemas marinhos pode estar sendo comprometido pela sua remoção do ambiente. Nos ambientes de praia arenosa analisados neste estudo, a população de Cassis tuberosa é estruturalmente jovem, o que caracteriza assim uma área de importância no recrutamento desta espécie. Nas áreas recifais estudadas, a população do gastrópode é predominantemente adulta, caracterizando uma área importante no desenvolvimento da espécie, podendo favorecer o estágio reprodutivo e consequentemente o crescimento da população. A ausência de captura de C. tuberosa tanto no ambiente de planície arenosa quanto nos recifes justifica a densidade populacional deste gastrópode, que pode ser considerada alta nas áreas estudadas. Em uma perspectiva de conservação, sugerimos que os ambientes tratados neste estudo sejam locais em potencial para monitoramento de populações naturais de C. tuberosa e para o desenvolvimento de estudos populacionais e ecológicos mais detalhados que colaborem para elaboração de planos de manejo para esta espécie.

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Parente, Aragão Ticiana. "CASSIA VIRGÍNICA® (Cassia occidentalis L.): abordagem farmacológica e toxicológica." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/3235.

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Cassia occidentalis L., conhecida popularmente como Fedegoso, é amplamente utilizada como medicamento natural em regiões de florestas e outras áreas tropicais ao redor do mundo, para o tratamento de cólicas intestinais e uterinas, estados febris, processos inflamatórios e como diurético, laxante, expectorante e abortivo. O fitoterápico CASSIA VIRGÍNICA®, comercializado pelo Laboratório Pernambucano (LAPERLI), preparado a partir de caules e folhas de Cassia occidentalis, tem sido indicado para o tratamento de gripes, febres, úlceras varicosas e erisipelas. O presente trabalho teve como objetivo avaliar a presença de efeitos antiinflamatório, analgésico, antipirético e antiulcerogênico, bem como o potencial toxicológico reprodutivo do fitoterápico CASSIA VIRGÍNICA®. Foram usados ratos Wistar e camundongos, de ambos os sexos, adultos, tratados oralmente com o extrato seco de CASSIA VIRGÍNICA® em diferentes doses, 50, 100, 200, 250, 400 e 500mg/kg, na dependência do ensaio realizado. O estudo farmacológico foi realizado utilizando o modelo de edema de pata induzido por injeção subplantar de carragenina, dextrana e histamina, para avaliar a atividade antiinflamatória aguda; o modelo de analgesia utilizando o ácido acético para indução de contorções abdominais; o modelo de febre induzida por levedura de cerveja e o modelo de úlcera induzida pela administração de etanol. Para avaliar a toxicidade reprodutiva, ratas Wistar prenhes foram tratadas oralmente, durante os períodos de pré-implantação (1º ao 6º dia de gestação) e organogênese (7º ao 14º dia de gestação), nas doses de 250mg/kg e 500mg/kg. No 20º dia de gestação, as ratas foram sacrificadas, laparotomizadas e avaliadas quanto a parâmetros reprodutivos (número de fetos vivos e mortos, relação feto/mãe, massa dos fetos, das placentas e dos ovários, número de corpos lúteos, relação corpo lúteo/mãe, número de sítios de implantação, índice de implantação, número de sítios de reabsorção, perda pré e pósimplantação). Os resultados obtidos mostraram que o extrato seco de CASSIA VIRGÍNICA® produziu uma redução máxima aproximada de 55% e 41% no edema de pata induzido pela carragenina e dextrana, respectivamente, porém não, no edema induzido pela histamina. Houve diminuição significativa das contorções abdominais nos animais tratados com o fitoterápico de 71, 60 e 62%, respectivamente nas doses de 100, 200 e 400mg/kg. Com relação à atividade antipirética, o fitoterápico na dose de 400mg/kg produziu redução significativa da temperatura, maior do que 1°C (36,58±0,19 para 35,32±0,48), a partir da primeira hora de administração, de maneira semelhante à produzida pela dipirona (35,23±0,23). O extrato protegeu a mucosa gástrica contra lesões induzidas por etanol nas doses de 100 e 200mg/kg com percentual de área ulcerada igual a 8,52±1,34% e 11,62±1,24% correspondendo a uma redução em relação ao controle (19,73±2,41), de 56 e 41% da área ulcerada. Os resultados mostraram que não ocorreram diferenças estatisticamente significantes quanto aos parâmetros reprodutivos avaliados. Porém, foi constatada a presença de feto morto, tanto na dose de 250 quanto de 500mg/kg do extrato seco de CASSIA VIRGÍNICA®. Os resultados indicam que o fitoterápico possui atividades antiedematogênica, analgésica e antipirética, porém, mais estudos são necessários para esclarecer os mecanismos envolvidos nestas atividades. A vantagem do fitoterápico em relação aos antiinflamatórios atuais é que esta não apresenta propriedade irritante de mucosa gástrica, pelo contrário, possui um efeito gastroprotetor. A constatação de feto morto sugere que os estudos devem ser ampliados para melhor caracterizar os efeitos tóxicos do fitoterápico e seu uso não deve ser recomendado durante o período de gestação

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Iavorski, Alessandro. "Cônicas e curvas de Cassini." Universidade Tecnológica Federal do Paraná, 2014. http://repositorio.utfpr.edu.br/jspui/handle/1/809.

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CAPES
Este trabalho foi desenvolvido com o propósito de servir de material de apoio para professores e alunos de matemática. Apresenta a exploração de algumas curvas como lugar geométrico dos pontos que satisfazem uma determinada propriedade. Apresenta como sugestão de trabalho uma família de curvas chamadas de curvas de Cassini, que são determinadas por uma propriedade similar `a propriedade que define as cônicas. Propõe atividades envolvendo as cônicas e as curvas de Cassini, para que essas atividades possam ser utilizadas em sala de aula e para que possam servir de base para elaboração de outras.
This work was developed with the purpose of serving as a support material for teachers and students of mathematics. Presents the exploration of some curves as locus of points that satisfy a given property. Presents as suggestion of work a family of curves called Cassini curves, which are determined by a property similar to the property that defines the conics. Proposes activities involving the conics and curves of Cassini so that these activities can be used in the classroom and what can be the basis for development of other.

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Gonçalves, Barbosa da Silva Mirtes. "Avaliação toxicológica pré-clínica do extrato seco de Cassia occidentalis L. (CASSIA VIRGÍNICA®)." Universidade Federal de Pernambuco, 2009. https://repositorio.ufpe.br/handle/123456789/3269.

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Cassia occidentalis L. (Leguminosae) popularmente conhecida como fedegoso é geralmente encontrada em regiões de florestas e em outras áreas tropicais ao redor do mundo. Na medicina tradicional, raízes, folhas e caules são usados como laxante, antiinflamatório, analgésico, antipirético, diurético, hepatoprotetor, vermicida e abortivo. Baseado principalmente no largo uso popular, a Cassia occidentalis é comercializada por alguns laboratórios farmacêuticos entre eles o Laboratório Pernambucano Ltda. (LAPERLI) com o nome comercial de CASSIA VIRGÍNICA®. O fitoterápico CASSIA VIRGÍNICA®, preparado a partir de caules e folhas de Cassia occidentalis (CO), tem sido indicado para o tratamento de gripes, febres, úlceras varicosas e erisipelas. Apesar do amplo uso desta espécie, poucos são os trabalhos disponíveis na literatura sobre seu potencial toxicológico. A maioria dos estudos toxicológicos utilizando Cassia occidentalis, refere-se à toxicidade de suas sementes. Neste sentido, o objetivo deste trabalho foi avaliar a segurança da administração oral do extrato seco de caules e folhas de Cassia occidentalis (CASSIA VIRGÍNICA®) em ratos Wistar de ambos os sexos. Para isto, foram realizados testes de toxicidade aguda nas doses de 0.625 a 5.0 g/kg, de toxicidade subcrônica e de toxicidade reprodutiva nas doses de 0.10, 0.50 e 2.5 g/kg/dia. Os resultados demonstraram que, nos estudos de toxicidade aguda, CO não produziu morte ou sinais de toxicidade em doses de até 5.0 g/kg. A administração por 30 dias de CO não alterou os parâmetros bioquímicos e hematológicos dos animais tratados, que se mantiveram dentro dos valores de referência para espécie. Entretanto, foi constatada uma discreta diarréia durante o período de tratamento. Não foram observadas alterações significativas na massa corporal nem no consumo de água e ração. Também não foram registradas alterações significativas nas massas, absoluta e relativa, e nem na morfologia macroscópica externa ou microscópica dos principais órgãos. Nos estudos que avaliaram a capacidade reprodutiva em machos, o tratamento durante 60 dias com CO não produziu efeitos tóxicos sobre os parâmetros reprodutivos ou sobre os conceptos. Além disso, não houve alteração significativa nas massas dos órgãos reprodutivos (epidídimo, vesícula seminal, ducto deferente, testículos, próstata) nem no número de espermatozóides. Desta forma, conclui-se que extrato seco de caules e folhas de Cassia occidentalis (CASSIA VIRGÍNICA®) é seguro por via oral, uma vez que apresentou baixa toxicidade aguda e subcrônica e não interferiu na capacidade reprodutiva dos ratos Wistar

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Casiday, Augustine Michael Cortney. "Tradition and theology in John Cassian." Thesis, Durham University, 2002. http://etheses.dur.ac.uk/1726/.

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11

Jasinski, J. M. "Cassini observations of Saturn's magnetospheric cusp." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1470751/.

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The magnetospheric cusp is a funnel-shaped region where shocked solar wind plasma is able to enter the high latitude magnetosphere via the process of magnetic reconnection. The first in-situ analysis of the cusp region at Saturn is presented using data from the Cassini spacecraft, primarily from particle instruments and magnetic field observations. The analysis is presented in three sections. Firstly, two high-latitude spacecraft crossings are confirmed to be cusp observations by: (i) comparing the observed plasma with that of the magnetosheath and the adjacent magnetosphere, (ii) investigating the direction of the observed ions and (iii) analysing the composition of the plasma. The ion observations are shown to be a result of `bursty' reconnection occurring at the dayside magnetopause. The field-aligned distances to the reconnection site are calculated from the observed energy-pitch angle dispersions. Secondly, all the observations of the cusp are presented for the high latitude spacecraft orbits between 2007 and 2013. A comparison of the observations is made as well as classification into groups due to varying characteristics. The locations of the reconnection site are calculated and compared to the literature. The events are also compared to solar wind propagation models to investigate any correlations. Finally, the magnetic field observations of the cusps are analysed, focusing on the diamagnetic depressions. This characteristic is not observed in all of the cusps, and the possible explanations for this are discussed. The data are subtracted from a magnetic field model, and the calculated magnetic pressure deficits are compared to the particle pressures. A high plasma pressure layer in the magnetosphere adjacent to the cusp is discovered to also depress the magnetic field. A summary of the consequences of this work is discussed specifically regarding the ongoing debate of the role of reconnection at Saturn and its influence on magnetospheric dynamics.

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Kim, Jinha. "The spiritual anthropology of John Cassian." Thesis, University of Leeds, 2002. http://etheses.whiterose.ac.uk/288/.

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This thesis is an investigation into the spiritual anthropology of John Cassian, who composed two monastic works, the Institutes and the Conferences. Although Cassian transmits the teachings of the Egyptian desert fathers living in the later fourth century, many polemical mind-sets, from his Latin contemporaries to modem critics, have not been able simply to accept his delivery with a spirit of respect and support. In his texts, the doctrine of free will and grace has been judged to be Semi-Pelagian through the viewpoint of Augustinian orthodoxy. Moreover, since Salvatore Marsili's comparative study in the 1930s, it has been accepted that Cassian's ascetic theology depended heavily on the writings of Evagrius Ponticus. Thus, the authenticity of his texts has been obscured for over fifteen hundred years in the West. Consequently, they have been regarded as second-class materials in the primitive desert monastic literature. This thesis re-examines the above settled convictions, and attempts to defend Cassian's repeated statements that he wrote what he had seen and heard in the desert. As the two assertions both relate to anthropological issues, the thesis investigates Cassian's spiritual anthropology-, human created nature, the Fall, its results, salvation, perfection, free will and grace. Chapter I uses as the context Cassian's life and the monastic setting of Gaul that had an influence on his works. Chapter II explores a literary feature of his writings and identifies the authenticity of Cassian's texts in comparison with the desert monastic literature. Here, the thesis argues against the dominant assumption of his dependence on Evagrius'works and reveals that Cassian was not a transmitter of the Evagrian schemata. Chapter III focuses on the instructions of created human nature in Cassian's texts and establishes that they were derived from the Alexandrian and the desert theological tradition, not that of the Evagrian Origenist. Chapter IV deals with the Fall and its effect on human nature. In the process, the thesis verifies that Conferences XIII does not offer an alternative to the Augustinian teachings on grace, but reflects the doctrinal milieu within the Alexandrian theology, which was to be regarded as Semi-Pelagian in the eyes of later Augustinianism. Chapter V presents soteriology in Cassian's works, in which all related texts show the Eastern synergistic tendencies regarding grace and free will as cooperating harmoniously with each other for salvation. Overall, the thesis asserts that distinctive divergences and inconsistencies among the speakers in treating each theme serve to verify the authenticity of Cassian's Abbas. The thesis concludes that Cassian was,indeed,the most notable transmitter of oral and lived Egyptian monastic theology to the West, as he claimed.

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Ruchikachorn, Nutthaporn. "Endophytic fungi of Cassia fistula L." Thesis, Liverpool John Moores University, 2005. http://researchonline.ljmu.ac.uk/5773/.

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Endophytic fungi from Cassia fistula or golden shower, a well known medicinal plant in Thailand and Asia, were isolated from trees growing in three geographical separate sites. These locations were Kanchanaburi, Nakhon Ratchasima and Bangkok and were selected to allow comparisons between their endophytic assemblages and to evaluate these data in relation to differences in plant diversity and density and local environment. Kanchanaburi which was the site closest to a natural forest situation provided the highest number of isolates with Bangkok, where the trees were isolated individuals, having the least. Members of the Xylariaceae proved to be common and frequent isolates especially species of Xylaria and Daldinia but Nemania and Hypoxylon were also obtained. Phomopsis was also well represented and clearly was dominant at the Kanchanaburi site. Species of Fusarium, Colletotrichum, Penicillium, Nigrospora, Coprinus and Psathyrella were also identified but were occasional isolates. Differences in endophytic assemblages between samples obtained early in the rainy season (July, 2001) with those sampled towards the end of the rainy season (December, 2001) were found to occur in the Nakhon Ratchasima samples with over twice as many isolates obtained from the December samples. This is likely to be a reflection on the longer exposure period to the potential inoculum of these leaves. A total of 956 endophytic isolates were obtained from the three sites with samples from Kanchanaburi (December 2000) and Bangkok and Nakhon Ratchasima in July 2001 with a further samples from Nakhon Ratchasima in December, 2001. Isolations were also made from different anatomical regions of the leaf, leaf lamina, midrib and veins. There were no appreciable differences in either the number of isolates obtained or an association between leaf area and specific fungal species. Identification of many xylariaceous endophytic isolates is well known to be problematic since Xylaria species rarely produce their anamorphic form in culture and virtually no members of the Xylariaceae develop their teleomorph in culture. Therefore molecular techniques were used to compare DNA sequences of the ITS region from a selection of endophyes with sequences obtained from teleomorphic material, or cultures derived from teleomorphs of identified and authenticated Xylariaceae. Comparisons were also made with data held in GenBank. This enabled the identity of a number of taxa to be made although more sequences from Xylaria species are required for future investigations. A number of non-xylariaceous taxa were also named as a result of DNA sequence comparisons. Secondary metabolites from the xylariaceae were also investigated and their metabolite profiles used to support identifications. The metabolite profiles proved to be a useful tool to confirm doubtful endophytic isolates when their DNA sequences could not place them with certainty in a right group. Together with extracts from other endophytic species, their inhibitory effects on bacteria and fungi were tested. Cassia endophytes were found to show low antimicrobial activity. However, they may later be shown to have other activities when when tested e. g. anti-malarial, anti-cancer and anti-HIV.

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Brighi, Giancorrado. "Data Analysis of Cassini Bistatic Radar Experiments." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24323/.

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The purpose of this work is to analyse bistatic radar data collected by the Cassini spacecraft about Titan's surface, providing profiles of dielectric constant and rms surface slope with horizontal scales of centimeters to meters. These properties are plotted against longitudes and latitudes of Titan, supported by discussions about the consistency between computed values and present knowledge of general features of Titan geomorphology. The entire work is carried out on Python, with the help of the spiceypy package from NASA NAIF, as well as other useful packages like cartopy, scipy and numpy. General algorithms for signal processing of the bistatic radar data are developed, aimed at obtaining the spectra of the echoes scattered by Titan's surface. Once the reflections' spectra are available, the rms slope and the dielectric constant can be computed. The assessment of the rms slope, proportional to the spectral broadening of the echoes, consists on fitting echoes' spectra by means of a Gaussian template, to later evaluate the full-width half-power of the fitting curve. The dielectric constant is computed from the power ratio between orthogonally polarized components of signal reflections from Titan, and from the knowledge of the incidence angle of reflection. Five flybys, of the thirteen available ones, have been chosen to carry out the following study, trying to analyse bistatic observations spanning over regions of Titan expected to be morphologically different. As a general trend, the dielectric constant estimates are consistent with the expected materials covering the surface of the planet, while the rms slope results are more valuable if read in a comparative way instead of looking at them from an absolute point of view. The main issues with data analysis of bistatic radar experiments are also mentioned, from the inapplicability of the quasi-specular model to beam-limitation of computed results, and sometimes tackled in a qualitative manner.

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Horst, Sarah M. "Post-Cassini Investigations of Titan Atmospheric Chemistry." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145467.

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The arrival of the Cassini-Huygens mission to the Saturn system ushered in a new era in the study of Titan. Armed with a variety of instruments capable of remote sensing and in situ investigations of Titan's atmosphere and surface, Cassini and Huygens have provided a wealth of new information about Titan and have finally allowed humankind to see its surface. This work focuses on two discoveries made by the Cassini Plasma Spectrometer (CAPS): the detection of oxygen ions (O+) precipitating into Titan's atmosphere (Hartle et al., 2006) and the discovery of very large positive (Waite et al., 2007; Crary et al., 2009) and negative ions (Coates et al., 2007, 2009) present in Titan's thermosphere.Through the use of a photochemical model, I demonstrate that the observed densities of CO, CO₂ and H₂O can be explained by a combination of O and OH or H₂O input to the upper atmosphere. Given the detection of O+ precipitation into Titan's upper atmosphere, it is no longer necessary to invoke outgassing from Titan's interior as a source for atmospheric CO or to assume that the observed CO is the remnant of a larger primordial abundance in Titan's atmosphere. Instead, it is most likely that the oxygen bearing species in Titan's atmosphere are the result of external input, most likely from Enceladus.I have also used very high resolution mass spectrometry to investigate the com- position of Titan aerosol analogues, or "tholins". Although there are an enormous number of molecules present in tholin samples, they exhibit numerous patterns, in- cluding very regular spectral spacing. These patterns may help constrain the com- position of the very large ions observed in the CAPS spectra, since the resolution of the instrument makes identification of the molecules impossible. Additionally, tholins produced with CO possess molecules of prebiotic interest, including all 5 nucleotide bases and the 2 smallest amino acids (glycine and alanine). This indicates that chemistry occurring in Titan's upper atmosphere may be capable of forming incredibly complex organic molecules, which may have implications for the origin of life on Earth and elsewhere in the universe.

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Danton, Ombeline. "Extraction de substances naturelles antalgiques à partir de plantes utilisées dans la pharmacopée traditionnelle au Mali." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAC001/document.

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Le travail présenté dans ce manuscrit porte sur l’isolation de métabolites secondaires de plantes utilisées en médecine traditionnelle au Mali. Après avoir réalisé une enquête ethnopharmacologique, mis en parallèle avec la littérature, trois plantes ont été sélectionnées pour être étudiées : Cassia sieberiana DC., Vitex madiensis Oliv. et Pericopsis laxiflora (Benth.) Meeuwen. L’activité analgésique des extraits aqueux et méthanoliques de ces plantes ont été évaluées. Les résultats nous ont mené à conduire un fractionnement bio-guidé des extraits méthanoliques de Cassia sieberiana DC. et de Pericopsis laxiflora (Benth.) Meeuwen. Huit composés ont été isolés à partir de fractions de l’extrait méthanolique de Cassia sieberiana DC., parmi lesquels quatre nouvelles molécules et trois nouveaux stéréoisomères ont été identifiés. Onze composés ont été isolés à partir de fractions de l’extrait méthanolique de Pericopsis laxiflora (Benth.) Meeuwen. Ce travail de recherche a permis d’approfondir nos connaissances sur la composition chimique de Cassia sieberiana DC. et de Pericopsis laxiflora (Benth.) Meeuwen et leur potentielle activité antalgique
The present work deals with the isolation of analgesic secondary metabolites from plants used in traditional medicine in Mali. After conducting an ethnopharmacological study and comparing it with the literature, three plants were selected to be studied: Cassia sieberiana DC., Vitex madiensis Oliv. And Pericopsis laxiflora (Benth.) Meeuwen. The analgesic activity of their aqueous and methanolic extracts were screened. Results lead us to realise a bioguided partitionning on the methanolic extracts of Cassia sieberiana DC. and Pericopsis laxiflora (Benth.) Meeuwen. Eight coumpounds were isolated from analgesic fractions of methanolic extract of Cassia sieberiana DC., among which four new compounds and three new stereoisomers were identified. Eleven coumpounds were isolated from analgesic fractions of methanolic extract of Pericopsis laxiflora (Benth.) Meeuwen. This research work allowed us to deepen our knowledge about the chemical composition of Cassia sieberiana DC. and Pericopsis laxiflora (Benth.) Meeuwen and their potential analgesic activity

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Gingras, Denis. "René Cassin et les droits de l'homme." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25238.pdf.

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Wang, Yu. "Analyse von Telemetriesignalen und Radar-Rückstreusignalen zur Rekonstruktion von Bahnstörungen interplanetarer Raumsonden am Beispiel der simulierten Abstiegsdynamik der Huygens-Sonde." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974189200.

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Srama, Ralf. "Vom Cosmic-Dust-Analyzer zur Modellbeschreibung wissenschaftlicher Raumsonden." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962125466.

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Fletcher, Leigh Nicholas. "Saturn's atmosphere : structure and composition from Cassini/CIRS." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445756.

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Van, Alphen-Stahl Jonathan. "Phylogeograpy of Aphanicercella cassida (Plecoptera : Notonemourida) : cryptic speciation?" Bachelor's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/25612.

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Stoneflies (Plecoptera) in South Africa are limited to cool pristine mountain streams. This provides them with very limited habitat in which to survive. The species of stonefly studied in this project (Aphanicercella cassida) has a very wide distribution unlike most other species which have a limited range. Of particular interest is a population in Mpumalanga (north of South Africa) which is very disjunct from the other populations of A. cassida found widely in the southwestern Cape. Despite this large geographic distance the insects appear to be morphologically identical to one another. It is believed that there is limited or no gene flow between the northern and southern populations as stoneflies are poor fliers. Molecular analysis of the cytochrome oxidase I gene in the mitochondrial DNA was analysed to see if any genetic differentiation was occurring inspite of the morphological homogeneity. A 557 base pair region was compared across three populations of A. cassida one in Mpumalanga and two in the southwestern Cape. Two congeneric species, A. bullata and A. scutata, were used as outgroups. The findings of this study were quite dramatic. The northern population is extremely different from the southern populations at the molecular level. There is more variation between the two populations of A. cassida than between the two outgroup species and the split between the two disjunct populations displays evidence of an ancient vicariance event. This finding definitely warrants further investigation into whether the population of A. cassida in Mpumalanga is a cryptic species. More sampling has to be done within the studied populations and more populations should be added to the analysis before any definite decision can be made regarding this fascinating emergence of possible cryptic species in South African stoneflies.

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LIVLJAHIC, KATARINA. "L'antiphonaire monte cassino, archivio della badia, ms 542." Paris, EPHE, 1998. http://www.theses.fr/1998EPHE4041.

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Le sujet central de la these est l'etude du seul antiphonaire note, conserve dans les archives de l'abbaye de monte cassino, en italie meridionale. Le manuscrit est une source destinee a l'usage, lors de l'office. Il est probablement compose dans le scriptorium cassinien (12e s. ) pour une des eglises paroissiales proches et dependantes de monte cassino. La these comporte son analyse codicologique, paleographique et liturgique, ainsi qu'une analyse modale de son fonds d'antiennes. Elle demontre son appartenance au fonds gregorien, tout en conservant des influences du style musical beneventain
The main topics of the thesis is a study of the only notated antiphonary conserved in the archive of the monte cassino abbey, in southern italy. The manuscript is an office source. It was probably made in cassinese scriptorium (12th c. ) and used in one of the dependant churches. The thesis contains its codicological, paleographic and liturgical analysis, and also a modal analysis of its antiphon repertory. If shows that the antiphonary belongs to the gregorian repertory, but conserves some influences of the beneventan musical style

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Muzanila, Yasinta C. "Processing of cassava, residual cyanogens and mycotoxin content tradionally processed cassava products." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263048.

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Maia, Maria Augusta da Silva Adrego. "Cassiano Branco - 1897-1970." Master's thesis, Instituições portuguesas -- UNL-Universidade Nova de Lisboa -- FCSH-Faculdade de Ciências Sociais e Humanas -- -Departamento de História da Arte, 1986. http://dited.bn.pt:80/29804.

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Carvalho, Maria de Jesus Mendes de. "Cassiano Branco - a obra." Master's thesis, Instituições portuguesas -- -Universidade Lusíada, 1998. http://dited.bn.pt:80/30326.

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Jeller, Helma. "Pré-condicionamento em sementes de Cassia excelsa Schrad." Universidade Federal de São Carlos, 2002. https://repositorio.ufscar.br/handle/ufscar/1893.

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Universidade Federal de Sao Carlos
Cassia excelsa is a woody species commun in cerrado and srubland of brazilian northeast, known by cassia-do-nordeste . It could be used in landscape place and due to small size is used in street arborization, and could be recommended to recomposition of degradated areas. The aim of this work was to extend the knowlege about the ecophysiological behaviour, with the the study of priming in seed germination. For this purpuse, it was evaluated the effects of water and PEG solutions (-0,2; -0,4 and -0,6 MPa) in uptake process at 20ºC. The effects of the drying and storage after priming; the answer under water, thermic and salt stress after priming was also verified. Besides it, the priming effects in seed viability and vigor under optimal conditions (27ºC) were observed by eletrical conductivity, accelerated aging and submersion tests. In all the tests was used 4 replicates of 25 seeds, with daily evaluation, and considered germinated when radicle was > 2 mm long. According to the results of uptake curve of Cassia excelsa seeds was observed that with the decreased in the osmotic potential increase the time necessary to priming. At optimal temperature (27ºC) the answer of primed seeds was efficient if water or PEG solution at -0,2 MPa was used, and this answer is maintened after 15 days of storage at 5ºC, but the drying of the seeds overcome the positive effects of the pré-treatment. The priming in water or in PEG solutions increased germination percentage under water, salt and thermal stress, however, with restriction to germination rate. The electrical conductivity of the primed seeds in water or in PEG was reduced, constrated to the non-primed seeds, and increased in the dried seeds after the priming. The priming in water or PEG was efficiente to overcome the deteriorative process occurring in aging, in dehidrated and in moist seeds, after priming. The seed vigor of primed seeds was no affected by submersion in distilled water during diferents time periods.
Cassia excelsa Schrad. é uma espécie de porte arbóreo encontrada no cerrado e nas caatingas do nordeste brasileiro, conhecida também como cassia-do-nordeste. Pode ser empregada em paisagismo em geral e devido ao seu pequeno porte é utilizada na arborização urbana, podendo ser indicada para plantios associados a outras espécies destinados a recomposição de áreas degradadas (Figura 1). Considerando que o período compreendido entre a semeadura e o estabelecimento da planta é uma fase crucial no ciclo reprodutivo da planta e que o pré-condicionamento pode melhorar o desempenho germinativo das sementes, este trabalho tem por objetivo contribuir para o conhecimento do comportamento ecofisiológico desta espécie, a partir de estudos dos efeitos do pré-ondicionamento na germinação das sementes de Cassia excelsa. Para tanto, avaliou-se o efeito da água e soluções de PEG 6000 (a -0,2; -0,4 e -0,6 MPa) na curva de embebição a 20ºC; verificou-se o efeito da secagem e armazenamento após o condicionamento; avaliou-se a resposta sob condições de estresse hídrico, térmico e salino após o condicionamento; e por último, investigou-se o efeito do condicionamento osmótico na viabilidade e vigor das sementes, sob condições ótimas (27ºC) a partir do teste de condutividade elétrica, envelhecimento precoce e teste de exaustão. Utilizou-se em cada experimento 4 repetições de 25 sementes escarificadas, com avaliação diária, considerando-se sementes germinadas aquelas que apresentavam radícula > 2 mm. A partir curva de embebição das sementes de Cassia excelsa verificou-se que com a redução do potencial osmótico da solução aumenta o tempo necessário para o condicionamento osmótico. Em condição ótima de temperatura (27ºC) as sementes respondem positivamente ao condicionamento, se forem utilizadas água destilada ou soluções de PEG a -0,2 MPa, sendo mantida esta resposta durante o armazenamento por 15 dias a 5ºC, contudo, a secagem das sementes reverte os efeitos positivos obtidos pelo tratamento. Sob condições de déficit hídrico, sob temperaturas sub ou supra ótima e salinidade elevada houve um aumento na germinabilidade das sementes pré-condicionadas, tanto com água como em PEG, porém com restrição à velocidade de germinação. A partir do teste de condutividade verifica-se que as sementes condicionadas em água ou em PEG apresentaram redução na lixiviação de eletrólitos, comparado às sementes não condicionadas (controle), e as sementes que foram secas após o condicionamento apresentam maior lixiviação do que as úmidas. O précondicionamento com PEG ou água destilada foi eficiente em reverter o processo de deterioração que ocorre durante o envelhecimento precoce, tanto para as sementes que foram secas ou mantidas úmidas, após o condicionamento. O vigor das sementes não foi afetado pela submersão das sementes por 24, 48 e 72 horas após o pré-condicionamento em água ou em PEG.

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Ajaiyeoba, E. O., J. S. Ashidi, Larry Commander Okpako, P. J. Houghton, and Colin W. Wright. "Antiplasmodial compounds from Cassia siamea stem bark extract." Wiley, 2008. http://hdl.handle.net/10454/4529.

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no
Cassia siamea L. (Fabaceae) was identified from the southwest Nigerian ethnobotany as a remedy for febrile illness. This led to the bioassay-guided fractionation of stem bark of the plant extract, using the parasite lactate dehydrogenase assay and multi-resistant strain of Plasmodium falciparum (K1) for assessing the in vitro antimalarial activity. Emodin and lupeol were isolated from the ethyl acetate fraction by a combination of chromatographic techniques. The structures of the compounds were determined by spectroscopy, co-spotting with authentic samples and comparison with literature data. Both compounds were found to be the active principles responsible for the antiplasmodial property with IC50 values of 5 µg/mL, respectively.

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Etessami, Pantea. "Mutagenesis studies on the genome of cassava latent virus : (African cassava latent virus)." Thesis, University of East Anglia, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235620.

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29

Driver, Steven David. "The reading of Egyptian monastic culture in John Cassian." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1995. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ28139.pdf.

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30

Kellett, Stephanie. "Cassini observations of the ring current in Saturn’s magnetosphere." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9633.

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In this thesis we have employed plasma and magnetic field data from the Cassini spacecraft in order to better understand Saturn’s ring current region. Three data studies are presented along with a derivation of the general expression for the field-perpendicular current density in terms of the plasma bulk parameters. In the first data study an essentially direct determination of the equatorial current sheet thickness was made using data from six north-south Cassini orbits. The dayside data indicated the presence of an equatorial current disk with a near constant half-thickness of ~1.5 RS. More variable conditions were found on the nightside. The data examined also provided evidence of a northward displacement of the current layer from the equatorial plane. Next, the nature of the ring current in Saturn’s dayside magnetosphere was investigated. The total azimuthal current density was found to rise from small values near ~6 RS, peak at ~100 pA m-2 near ~8 RS, and then reduce to values below ~25 pA m-2 at distances beyond ~15 RS, up to the 20 RS limit of our study. The overall total current density profile was found to be similar to that produced by the pressure gradient current, but augmented in strength by factors of ~1.5-2.0 by the difference between the inertia and pressure anisotropy currents. Comparison of the current density profiles deduced from plasma data with those obtained from current disk modelling of the magnetic field perturbations showed good agreement with the gross features. Finally, both the local time dependency and temporal variability of Saturn’s ring current was explored using data obtained from eleven near-equatorial Cassini orbits. In general, the plasma parameters, azimuthal current, and related magnetic perturbation fields were found to exhibit only modest variations with local time and from pass-to-pass over the interval of this study.

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Voris, Trent T. "Nanosatellite Probes in Interplanetary Space: An Augmented Cassini Mission." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1774.

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The exploration of interplanetary space is one of the most challenging and costly ventures in human history. The relatively low amount of information on other sites beyond Earth is largely due to the rarity of effective trajectories as well as the high levels of risk and complexity inherent in innovative space exploration. One solution to this lack of information is the use of deployable satellite probes to help augment the main mission and its instrumentation. This “Mother- Daughter” architecture allows for the low-cost exploration of hazardous sites and numerous points of interest without compromising the primary mission. While the end goal is the use of nanosatellites on future interplanetary missions, this thesis focuses on an existing interplanetary mission, Cassini. The aim to demonstrate the scientific viability of this “Mother-Daughter” architecture can be achieved by locating numerous unexplored sites that could have been surveyed with a nanosatellite probe onboard Cassini. Each of these potential sites can be expanded into a unique science mission of its own, and in many cases the trajectories can be selected and optimized to better suit the practical design of a nanosatellite in the various interplanetary environments.

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Driver, Steven D. "John Cassian and the reading of Egyptian monastic culture /." New York : Routledge, 2002. http://catalogue.bnf.fr/ark:/12148/cb39266490j.

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Duarte, Marciel Lelis. "Tubetes e substratos na produção de mudas de cássia-rosa (Cassia grandis L.f) e canafístula (Cassia ferruginea (Schrad.) Schrader ex DC)." Universidade Federal de Viçosa, 2016. http://www.locus.ufv.br/handle/123456789/8367.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico
Diante da exploração, muitas vezes desordenada, dos recursos naturais, culminando na degradação das áreas e perda da biodiversidade, a recuperação ambiental por meio do plantio de espécies nativas é importante para reestabelecer o equilíbrio dos ecossistemas e para preservar as espécies. Mudas de qualidade são fundamentais para garantir o sucesso dos plantios florestais, pois possibilitam o maior crescimento e sobrevivência pós-plantio no campo. Para a produção de mudas de boa qualidade, entre vários fatores, a escolha adequada do recipiente e do substrato no qual as espécies serão cultivadas é de vital importância. Entretanto, para muitas espécies arbóreas nativas esse conhecimento ainda é escasso. O objetivo deste estudo foi avaliar o crescimento de mudas de cássia- rosa (Cassia grandis L.f) e canafístula (Cassia ferruginea (Schrad.) Schrader ex DC.), produzidas em tubetes de diferentes capacidades e substratos. Foi utilizado um fatorial 4 x 5, constituído de quatro substratos e cinco tubetes (35; 50; 120; 180 e 288 cm3 de capacidade) disposto em delineamento estatístico de blocos casualizados, com três repetições e 25 plantas por parcela. Os substratos testados foram: 100% substrato comercial (tropstrato florestal); 50% substrato comercial + 50% de casca de arroz carbonizada; 50% substrato comercial + 50% fibra da casca de coco; e 25% substrato comercial + 25% casca de arroz carbonizada + 25% fibra da casca de coco + 25% terra de subsolo). Ao fim do experimento foram determinadas a altura, o diâmetro, a massa de matéria seca da parte aérea (MSPA), a massa de matéria seca de raízes (MSR) e a massa de matéria seca total (MST), além das relações altura/diâmetro (RHDC), massa de matéria seca da parte aérea/massa de matéria seca de raízes (RMSPAMSR), altura/massa de matéria seca da parte aérea (RHMSPA) e índice de qualidade de Dickson (IQD). A capacidade dos tubetes e os substratos tiveram influência significativa no crescimento das mudas. O melhor crescimento das mudas de cássia-rosa ocorreu nos tubetes de 288 e 180 cm3 de capacidade, usando substrato composto por 50% de fibra da casca de coco + 50% substrato comercial. Já para as mudas de canafístula o melhor crescimento ocorreu nos tubetes de 288, 180 e 120 cm3 de capacidade, usando substrato composto por 50% de fibra da casca de coco + 50% substrato comercial e o substrato composto por 25% substrato comercial + 25% casca de arroz carbonizada + 25% fibra da casca de coco + 25% terra de subsolo.
Given to the exploration of natural resources, many times disordered, culminating in degradation of areas and loss of biodiversity, the environmental recovery through native species is important to reestablish the equilibrium of ecosystems and to preserve the species. Seedlings quality are fundamental to ensure the success of forest plantations, since they allow a better growth and survival once planted. For the production of quality seedlings it is necessary to know the proper choice of the container and the substrate in which species are cultivated. However, for many native woody species this knowledge is still scarce. The aim of this study was to evaluate the effect of size of tubes and types of substrates on the quality of seedlings of Cassia grandis L.f e Cassia ferruginea (Schrad.) Schrader ex DC, produced in tubes of different size and types of substrates. A factorial 4 x 5 consisting of four types of substrate and five volumes of tubes (35, 50, 120, 180 and 288 cm3 capacity) arranged in a randomized block design, with three replicates and 25 plants per repetition was used. Substrates tested were: 100% commercial substrate (forest tropstrato); 50% commercial substrate + 50% carbonized rice husk; 50% commercial substrate + 50% coconut fiber; and 25% commercial substrate + 25% carbonized rice hulls + 25% coconut fiber + 25% subsoil). An the end of the experiment data regarding to height, collar diameter, aerial part dry weight and root, and the ration between height and collar diameter (RHDC), height aerial part and dry weight (RHMSPA), aerial part dry weight root and dry weight (RMSPAMSR) and Dickson quality index (IQD) were collected. The best development of seedlings of cássia-rosa occurred in tubes of 288 and 180 cm3 capacity, using substrate composed of 50% coconut fiber + 50% commercial substrate. Regarding to seedlings of canafístula, the best development occurred in tubes of 288, 180 and 120 cm3 capacity, using substrate composed of 50% commercial substrate + 50% coconut fiber and the substrate composed of 25% commercial substrate + 25% carbonized rice hull + 25% coconut fiber + 25% subsoil.

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Mathende, Julius. "An analysis of the production of cassava as a food security option for Zimbabwe." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-12112006-165129/.

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Parsley, Robert Foust. "Understanding means living interpretation of Scripture according to John Cassian /." Theological Research Exchange Network (TREN), 1994. http://www.tren.com.

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Amuge, Teddy. "Genome-wide transcriptome analysis of cassava challenged with Ugandan cassava brown streak virus (UCBSV)." Thesis, University of Pretoria, 2019. http://hdl.handle.net/2263/72121.

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Cassava is staple to millions in Africa, yet cassava brown streak disease (CBSD) greatly threatens cassava production. This study reports the mechanism of cassava’s resistance to CBSD using Ugandan cassava brown streak virus (UCBSV), one of the two CBSD-causal virus species. In a green house, five varieties: Albert, Kiroba, Mkombozi, Namikonga and NDL06/132 were analysed for response to UCBSV at 20 time points. In the first experiment, Albert and Namikonga were compared. In the second experiment, all five varieties were studied. Plants were phentyped for foliar and root symptoms of CBSD, virus titre was measured using qRT-PCR while RNAseq and QuantStudio were used to determine gene expression. Virus infected plants of susceptible variety (Albert) developed clear leaf symptoms and necrotic storage roots. UCBSV-infected plants of Namikonga (resistant) showed minimal leaf symptoms and storage roots were non-necrotic. UCBSV titre was highest in susceptible variety (Albert), and very low in the resistant variety (Namikonga). More genes were differentially expressed in Namikonga (10,028) compared to Albert (688). In Namikonga, highest expression was recorded at 2 dag and 5 dag, when only two genes were differentially expressed in Albert. GO terms for phosphorelay signal transduction, ribosome and elongation factors were enriched in Namikonga and none in Albert. In another experiment, UCBSV-infected storage roots from Kiroba were non-necrotic. Defence genes identified in Kiroba were similar to Namikonga’s, except that in Kiroba, genes were highly expressed at 1 dag and 51 dag. One storage root of Mkombozi developed a necrotic spot. Mkombozi had no distinct pattern of defence-gene expression as seen in Kiroba and Namikonga. Varieties NDL06/132 and Albert were susceptible, and showed limited numbers of differentially expressed genes. Therefore, Kiroba and Namikonga are resistant to CBSD. The resistance mechanism involves up regulation of known defence proteins, and restricted multiplication of UCBSV in infected plants.
Thesis (PhD)--University of Pretoria, 2019.
Bill and Melinda Gates Foundation & University of Pretoria
Plant Science
PhD
Unrestricted

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37

Wellbrock, A. "Cassini plasma spectrometer observations of Titan's ionospheric electrons and ions." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1387441/.

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The work in this thesis uses data from the Cassini spacecraft in the Saturnian system to study the ionosphere and magnetic environment of Saturn’s largest moon Titan. The main instrument utilised is the Cassini Plasma Spectrometer – Electron Spectrometer (CAPS-ELS). Following the presentation of relevant background information, the first part of the thesis is concerned with the analysis of electrons in Titan’s ionosphere and exosphere, whereas in the second part we investigate observations of organic negative ions that can reach masses as high as 13,800 amu/q. The first of two electron topics is the study of photoelectrons in Titan’s ionosphere. We report on observations of photoelectrons (Coates et al., 2007a) in Titan’s exosphere and ionospheric tail that were created in Titan’s lower sunlit ionosphere. We compare observations to hybrid model results (Sillanpää et al., 2011) to confirm that photoelectrons can travel to these locations via magnetic field lines and discuss the implications for Titan’s ionospheric environment and magnetic tail. In the second electron topic we explore regions in Titan’s topside ionosphere where electrons undergo a change in energy of up to 100 eV. These events are observed predominantly on the hemisphere of Titan where the electric field of Saturn’s corotating magnetospheric plasma points away from the moon. A number of events also appear to be associated with pick up ions. The negative ion part of this thesis describes the investigation of factors that control the masses and number densities of negative ions (Coates et al., 2007b, 2009). These have been observed in the altitude range 950 – 1400 km which makes up the main part of Titan’s ionosphere. We find that the highest masses and densities are observed at the lower altitudes within this range. In addition, we reveal solar zenith angle trends for different mass groups, including a region of predominantly low densities near the day-night terminator.

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Fairbairn, Donald MacAllister. "Grace and Christology in Cyril of Alexandria and John Cassian." Thesis, University of Cambridge, 1999. https://www.repository.cam.ac.uk/handle/1810/272806.

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Santos, Elias Pereira dos. "Sorria meu bem, sorria: no ar, o Cassino do Chacrinha!" Universidade Federal de Minas Gerais, 2014. http://hdl.handle.net/1843/BUOS-9KWL9D.

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This work seeks to investigate the entities that, in relation to each other, compose the text and the textualities of an specific device: the programa de auditório Cassino do Charcinha, a TV show that aired in the 1980's on Rede Globo de Televisão and was replayed on Canal Viva in 2012/2013. Our effort is to comprehend how this independent and multidimensional device, composed by a variety of texts, recaptures and re-signifies elements from the first programas de auditório, entertainment products that were born in the radio (1940's). Strongly influenced by the irreverence of the Brazilian teatro de revista from the beginning of the Twentieth century e by the vivacity and diversity of the Brazilian circus, this kind of show finds its place also on TV since the 1950's. We understand textualities as processes of construction of unstable meanings, with its conditions constantly altered by the movement born in the relations of the entities of a text open to multiple meanings by the action of its readers. That movement, however, leaves its perceptible traces in some moments, that we try to capture in this study. The traces of these textualities are present even in today's programa de auditório devices.
Este trabalho visa investigar as entidades que se relacionam para compor o texto e as textualidades de um dispositivo específico: o programa televisivo de auditório Cassino do Chacrinha, veiculado nos anos 1980 pela Rede Globo de Televisão e reexibido pelo Canal Viva em 2012/2013. Interessa-nos perceber como este dispositivo independente e multidimensional, composto por textos diversos, relê e ressignifica elementos percebidos desde os primeiros programas de auditório, produtos de entretenimento que nasceram na mídia rádio (anos 1940). Fortemente influenciado pela irreverência do teatro de revista brasileiro do início do século XX e pela vivacidade e diversidade do circo brasileiro, esse tipo de programa tem marcante presença também na TV desde os anos 1950. Procuramos entender as textualidades como processos de construção de sentidos instáveis e com condições constantemente alteradas pelo movimento criado nas relações das entidades de um texto aberto a sentidos diversos pela ação de seus leitores. Mas este movimento também deixa suas marcas perceptíveis em alguns momentos que nos interessou perceber neste estudo. Estas textualidades marcantes estão presentes no dispositivo programa de auditório até os dias de hoje.

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Ramires, Paula Florencio. "Dimensão humana da qualidade ambiental: Balneário Cassino, Rio Grande-RS." reponame:Repositório Institucional da FURG, 2011. http://repositorio.furg.br/handle/1/2237.

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Dissertação(mestrado)-Universidade Federal do Rio Grande, Programa de Pós-Graduação em Geografia, Instituto de Ciências Humanas e da Informação, 2011.
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Visando contribuir com o planejamento ambiental esta pesquisa teve como objetivo avaliar a qualidade ambiental urbana percebida do Balneário Cassino. Fundado no final do século XIX com a finalidade de ser um espaço de lazer da aristocracia local o balneário passou por várias transformações ao longo do tempo, o que repercutiu na qualidade ambiental e de vida da população. Atualmente a implementação/estabelecimento do pólo naval traz novos desafios para a população local e para o poder público no sentido de reverter as repercussões negativas resultantes das transformações da paisagem ocorridas até então e manter a qualidade ambiental diante das novas mudanças em curso. Ao revelar a dimensão humana da qualidade ambiental do Balneário Cassino e o seu comportamento espacial, este pesquisa traz informações que podem ser utilizadas pelos tomadores de decisão para atender aos diferentes anseios e demandas dos grupos sociais (unidades espaciais) constituindo subsídios ao planejamento e gestão do Balneário Cassino. Para alcançar estes objetivos esta pesquisa recorreu às teorias e metodologias do planejamento ambiental e da percepção ambiental, bem como às geotecnologias.
To contribute to the environmental planning this study was to evaluate the perceived urban environmental quality of the Balneário Cassino. Founded in the late nineteenth century in order to be a leisure resort of the aristocracy, has undergone several transformations over time, which had repercussions on the environment and quality of life. Currently the implementation / establishment of the naval center brings new challenges for the local population and for the government to reverse the negative effects arising from changes in the landscape that have occurred so far and maintain environmental quality in the face of new changes taking place. By revealing the human dimension of environmental quality of the Balneário Cassino and its spatial behavior, this research provides information that can be used by decision makers to meet the desires and demands of different social groups (spatial units) are subsidies to the planning and management of the Balneário Cassino. To achieve these objectives this study drew on theories and methodologies of environmental planning and environmental perception, as well as geotechnology.

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Poltronieri, Sara. "Determination of the orbit of Titan from Cassini. Altimeter data." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425600.

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The research presented in this thesis concerns the improvement of Titan’s orbit determination by the means of the altimetric data captured by the Cassini’s RADAR instrument. The work carries out the development and implementation in the SOSYA (SOlar SYstem Astrometry) software tool, of a module, called SOSYA?ART (SOlar SYstem Astrometry?Altimetric Run Tool), that computes bodies’Orbit Determination by an altimetric type process. Moreover, the Measurements Simulation part of SOSYA has been enriched the introduction of the module that creates synthetic altimetric measurements at given observation times set. This research can be divided in four parts. The first part gives a brief introduction of the Cassini mission and a detailed description of the RADAR instrument on board the satellite with its features and scientific purposes. RADAR is a multimode instrument that uses the five beam antenna feed assembly associated with the spacecraft high gain antenna to transmit and receive electromagnetic radiation according to different operative modes: imaging mode, altimeter mode, radiometer and scatterometer mode. A precise observation sequence of observations is performed during each Titan’s encounter: within 25,000 km range active scatterometer measurements start, then the low resolution altimeter mode is planned between 9000 and 22.500 while the high resolution altimeter mode is performed between 4000 and 9000 km. The imaging mode is selected while the spacecraft altitude passes from 4000 km to its minimum value, then outbound observations are repeated in reverse order. Basic concepts of the radar theory and signal modulation are presented. Radar data acquisition is a type of remote sensing technique. These techniques acquire information detecting and measuring changes that the object causes on the surrounding field (potential, electromagnetic or acoustic field). In fact, radar altimetry involves bouncing microwave pulses off the surface of the target body and measuring the time it takes the echo to return to the spacecraft. The second part is concerned with the fundamentals of orbit determination. Statistical orbit determination is the set of techniques that allows the estimation of the orbital parameters of a spacecraft or a celestial body during its motion in the Solar System. It is the problem of determining the best estimate of the orbital parameters of a spacecraft or a celestial body, whose initial state is unknown, from observations influenced by random and systematic errors, using a mathematical model that is not exact. Then we give the detailed development of the geometrical observation model used to determine the altimetric measurement for the residuals computation at each observation time. The problem of orbit determination is solved by SOSYA?ART for Titan’s state at epoch, t0, keeping fixed the trajectory of Cassini spacecraft. Titan’s surface is considered as a sphere of 2575 km radius and the problem is solved in the reference frame centered on the barycenter of the Saturnian system. At each observation time, Cassini’s ephemeris and attitude values are read from SPICE’s SPK and CK kernels files and corrected for light time, while Titan’s states are integrated and interpolated by the means of SOSYA’s Orbit Simulation capability [2]. Then, as the field of view direction of RADAR beam is strictly connected to the spacecraft’s attitude, the intersection point with the surface is computed and residual value is found. The weighted least squares method is applied to fit to the observational data and the set of adjustable parameters are Titan’s position and velocity. The third part is dedicated to the altimetric data used and to the flybys during which they were collected by the Cassini RADAR. The altimetric observation processed in the software tool is the distance, or rather the range-to-target (RTT), measured from the antenna’s center of phase to the surface of the target body. The altimetric data have been received from CO.RI.S.T.A. (Consortium for Research on Advanced Remote Sensing Systems) and they have been collected in 12 of 44 Titan’s flybys, beginning from the flyby completed on 26th October 2004 (Ta) and up to the one completed on 20th December 2007 (T39). The total number of altimetric measurements processed is 13080 and they are not uniformly distributed in the 14 flybys: T13 and T25 have the lowest numbers of observations so they are precessed but not included in results discussion. For each of these encounters we searched for the SPK kernels, containing Cassini’s ephemerides, and the relative CK kernels, containing the spacecraft attitude matrices. In order to give a description of the flybys used in the Orbit Determination process, we implemented a simple SPICE-based routine that reads the ephemeris files and gives three output files containing respectively: 1) Cassini barycentric states, 2) Titan barycentric states and 3) Cassini states in Titancentered reference frame. Then by the use of Matlab, the states have been plotted in order to visualize the entire encounters in two different ways: the first one is the Titan-centric representation of the flyby while the second one is the orthogonal projection on the xy plane of the Saturn-barycentric passage. For each available flyby, we give its general description, as duration and the closest approach distance and time. Moreover we give tables that summarize the distribution over time of the altimetric observation sequence. The last part of the work is entirely dedicated to the Orbit Determination process and to the discussion about the solutions obtained for Titan’s states computed at the batch epochs by SOSYA?ART. Since the altimetric observation errors were not available, we have used a constant value for the weight of 80 m for all the observations corresponding to the maximum resolution value that the instrument achieves approximatively. Titan’s flybys T13 and T25 are have been processed but they are not discussed with the others results obtained because they have very few observations. The mean of all the rms values at first iteration is 4.703 km and it decreases to the value of 81.67 m at last iteration underlining the goodness of the solutions for Titan’s states obtained with respect the initial ones. The global mean of residuals at the first iteration is -340 m and it decreases to the global mean at the last iteration of ?4.296 · 10?4 km, giving the possibility of neglecting the bias estimation. The minimum value of standard deviation of the estimated position is 294 m, while the maximum value is 5.233 km. The standard deviation of the velocity ranges from a minimum of 6.322 · 10?2 m/s to a maximum value of 7.2 m/s. Although our estimation has been made only for Titan and yields particular and local solutions, the results are fully satisfying. Jacobson [8] obtained 1- uncertainties for Titan of 40 km along R, 150 km along T and 50 km along N. These results come from astrometry, radiometric tracking and spacecraft imaging data and estimating all the major Saturnian satellites. The accuracy of our solution is limited by the altimetric measurement errors and by the a priori covariance matrix values applied to the initial conditions of the natural bodies integrated. In fact we proved that the standard deviation errors effectively decrease by the use of different a priori variance matrices. In addition, the resulting accuracy of the estimation is due to the short orbital arcs considered in the orbit determination process over which the measurements are taken. Our research can be further extended to other mission scenarios in order to reach a better accuracy in the orbit determination of natural satellites by the means of altimetric data collected on board spacecrafts by radar or laser instruments. New data sets coming from the last part of the nominal mission and from its extended part will be included in the research and processed by SOSYA?ART. In this way we have a sufficient numbers of points at which Titan’s state has been computed and this becomes the basis on which starting the reconstruction of the improved moon’s orbit together with the other types of observation. In order to compute a global solution all over the entire tour with more accurate estimation of Titan’state, a multi-arc approach would be probably indicated. SOSYA?ART will be enriched by the consider covariance analysis module testing the impact of the introduction of the altimetric observations on the state estimation process without having the real data. The altimetric measurements simulation module will be improved by the introduction of the possibility of adding noise to the signal.

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Simons, Benedikt. "Cassius Dio und die Römische Republik Untersuchungen zum Bild des römischen Gemeinwesens in den Büchern 3 - 35 der "Rhomaika"." Berlin New York, NY de Gruyter, 2009. http://d-nb.info/999262092/04.

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Siritunga, Dimuth S. K. "Generation of acyanogenic Cassava (Manihot esculenta Crants) : Transgenic Approaches /." Connect to this title online, 2002. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1038927219.

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Thesis (Ph. D)--Ohio State University, 2002.
Title from first page of PDF file. Document formatted into pages; contains xxi, 201 p.: ill. Includes abstract and vita. Advisor: Richard Sayre, Dept. of Plant Biology. Includes bibliographical references (p. 184-201).

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Nelson, Graham. "Casson invariants of cobordisms." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320628.

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45

Naseem, Saadia [Verfasser]. "Molecular studies on the interactions between African cassava mosaic virus (ACMV) and East African cassava mosaic virus (EACMV-UG) infecting cassava (Manihot esculenta Crantz) / Saadia Naseem." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover, 2011. http://d-nb.info/1012624684/34.

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ALBUQUERQUE, Priscilla Barbosa Sales de. "Avaliação reológica da galactomanana extraída das sementes de Cassia grandis." Universidade Federal de Pernambuco, 2013. https://repositorio.ufpe.br/handle/123456789/13326.

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Galactomananas são caracterizadas como o maior grupo de polissacarídeos com capacidade de reserva de energia do endosperma de sementes de plantas, especialmente aquelas pertencentes à família Leguminosae, como a espécie Cassia grandis da subfamília Caesalpinioideae, amplamente encontrada na zona da mata do Estado de Pernambuco, Brasil. As galactomananas têm grande aplicação industrial como espessantes, emulsionantes, gelificantes, floculantes e formadores de película. O presente trabalho teve por objetivo a extração, caracterização e a avaliação das propriedades reológicas da galactomanana contida nas sementes da Cassia grandis. As sementes de C. grandis foram coletadas na cidade de Angelim, agreste do Estado de Pernambuco, e o processo de extração incluiu, primeiramente, remoção das vagens, seguido pela fervura em água destilada a 100ºC para retirada de suas cascas e secagem até peso constante. Posteriormente, as sementes sem casca foram trituradas em solução de NaCl 0,1M [5% (p/v)], filtradas através de tecido vual e tela de serigrafia (tipo 90) e precipitadas com etanol 46% (1:3 v/v). O precipitado foi filtrado em tela de serigrafia (tipo 110), lavado consecutivamente com etanol 100% e acetona pura, filtrado entre cada lavagem e finalmente seco e pulverizado. O rendimento da extração foi calculado pela porcentagem de matéria seca final obtida em relação ao peso inicial das sementes. A caracterização do polissacarídeo extraído foi realizada por espectroscopia de infravermelho transformada de Fourier (FTIR) e por difração de raios X. As propriedades reológicas foram determinadas em soluções aquosas da galactomanana nas concentrações de 0,5, 0,8, 1,0, 1,5 e 2,0% (p/v), em regime rotacional e oscilatório. A viscosidade e os módulos de armazenamento e perda de energia foram determinados e analisados em função da tensão, da frequência, da taxa de cisalhamento e da temperatura. A galactomanana foi eficientemente extraída e apresentou rendimento de 35,77% ± 7,83. Os resultados dos espectros do FTIR e da difração de raios X confirmaram que o polissacarídeo extraído das sementes de Cassia grandis é um polissacarídeo constituído principalmente de galactose e manose, ou seja, trata-se de uma galactomanana. As soluções aquosas deste polissacarídeo apresentaram comportamento pseudoplástico, devido o decaimento da viscosidade com a taxa de cisalhamento, revelando um regime newtoniano para concentrações de até 1%. Os módulos de ganho e perda de energia aumentaram continuamente em função da frequência de oscilação, indicando a ausência de ligações permanentes características de um gel em concentrações mais baixas; a 2%, porém, o polímero transforma-se em um gel fraco. Os estudos de tensão e deformação permitiram uma avaliação mais precisa desta transição e indicaram que o ponto de gelificação ocorre a 1,6% (p/v). Em conclusão, os resultados obtidos sugerem um potencial de aplicação biotecnológica para a galactomanana extraída das sementes de Cassia grandis, principalmente no que se refere à utilização de suas suspensões em revestimentos e géis úteis para indústrias farmacêuticas e alimentícias.

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47

Hager, Conroy Kathryn. "Shifting foundations : understanding the relationship between John Cassian and Evagrius Ponticus." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:aa7bc2cd-bdaf-4a46-aabc-ed601a7044d6.

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John Cassian is an Eastern-educated monk writing in the early fifth century for the monks of Gaul and is crucial to the development of Western monasticism through the transmission of Greek ascetic ideas to the Latin West. He is heavily influenced by the teachings of Evagrius Ponticus, a prolific late fourth-century Egyptian monk crucial to the development of Christian mysticism; however, there has been no clear line drawn between the influence of Evagrius and Cassian's own originality. While Cassian uses Evagrian asceticism to the fullest, he nevertheless places it onto a divergent theological foundation which fundamentally alters that inherited asceticism. Evagrius' asceticism is shaped by his anthropology, cosmology, soteriology, and eschatology - all of which are based on his understanding of Creation and Christology. The monk working through Evagrius' asceticism sees the world and all the divisions in it - e.g. body/soul, human/angel/demon, vice/virtue - as a temporary construct which facilitates the eventual obliteration of all divisions through salvation - including divisions between good and evil. Cassian, however, writes twenty years after Evagrius' death and in a changed theological atmosphere, in which Evagrius' basic premises have become more controversial. Cassian is able to work an ascetic program previously defined by Evagrian theology into a legitimate and coherent asceticism based on a different understanding of Creation. This resembles Evagrius' asceticism to such an extent, that he has been called "merely a Latin translator". However, through fleshing out and comparing Cassian's understanding of the practical, the eight principal vices, the spiritual battle, and the contemplative life, it becomes clear that Cassian has a fundamentally different understanding of Creation and Christology, and this changes the relationship between body and soul, created and Creator, and corruption and salvation - all fundamental areas in an effective and coherent asceticism. Therefore, although the frame of his asceticism is Evagrian, the theological underpinnings of that asceticism create a vastly different experience for the monk through a different definition of humanity and the relationship between created and Creator.

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Deias, Dalia. "Inventer l'Observatoire : sciences & politiques sous Giovanni Domenico Cassini (1625-1712)." Thesis, Paris, EHESS, 2020. http://www.theses.fr/2020EHES0165.

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En 1667, commence la construction de l’Observatoire à Paris. Dès son origine, c’est un projet qui représente une rupture dans l’Europe des savoirs. On le conçoit comme un magnifique palais installé dans un vaste parc au milieu d’autres constructions plus légères. Idéalement, les savants de la nouvelle Académie des sciences, fondée dans un même geste, pourront y loger, s’y réunir et y trouver toutes facilités pour se livrer à la pratique savante. Pour le roi, il s’agit avant tout de développer les connaissances astronomiques et géographiques : l’Observatoire est le réservoir de cette expertise cruciale et le symbole de son pouvoir et de son rayonnement.Au carrefour des sciences studies, de l’histoire des pratiques d’observation astronomique et des études sur les correspondances savantes à l’âge classique, cette thèse a pour objet de revenir sur l’histoire de l’Observatoire, en interrogeant à nouveaux frais les contours précis du projet initial et les modalités de sa mise en œuvre dans le Grand Siècle, qui correspond aux premières décennies de son existence. Revisitant les travaux classiques des historiens des sciences, notre étude se structure autour d’un ensemble considérable de lettres et de notes inédites de Giovanni Domenico Cassini et de ses correspondants. Professeur d’astronomie à Bologne jusqu’en 1669, astronome royal et premier savant courtisan de Louis XIV par la suite, Cassini est appelé en France pour donner un avis sur le bâtiment en construction. Il y vivra et travaillera pendant tout le Grand Siècle : ses manuscrits constituent une source particulièrement riche pour étudier cette institution, réinterroger les choix fondamentaux la concernant et suivre l’évolution de son dessein.De cet examen, nous concluons que bien que d’autres lieux d’observation céleste aient existé auparavant, Cassini invente une nouvelle forme d’organisation de la pratique savante. Fonctionnant sans règles explicites, l’Observatoire innove cependant grandement dans l’organisation du travail collectif au sein d’un établissement dédié à la pratique astronomique et dans la constitution de réseaux d’observateurs aux quatre coins du monde travaillant de manière coordonnée à la poursuite d’un projet commun au service de la monarchie. Nous montrons que le savant organise l’Observatoire autour d’un concept qui provient de son travail sur les méridiennes italiennes, l’esattezza des mesures et de l’écart entre terre et le ciel. Les techniques de l’Observatoire se répandront ainsi grâce à lui : les réseaux de sociabilité de l’Italien conditionneront le fonctionnement quotidien de l’établissement et la circulation des savoirs dans la ville et dans le monde entier
In 1667, the construction of the Observatoire de Paris began. From the very beginning, it was a project that represented a breakthrough in the Europe of knowledge. It was conceived as a magnificent palace set in a vast park in the middle of other lighter constructions. Ideally, the savants of the new Académie des sciences, founded in a single act, will be able to stay, meet and find all the facilities to engage in scholarly practice. For the king, it is above all a question of developing astronomical and geographical knowledge: the Observatoire is the reservoir of this crucial expertise and the symbol of its power and influence.At the crossroads of the science science, the history of astronomical observation practices and the studies on correspondence in the classical age, the aim of this thesis is to return to the history of the Observatoire, questioning once again the precise outlines of the initial project and the methods of its implementation in the Grand Siècle, which corresponds to the first decades of its existence. Revisiting the classic works of historians of science, our study is structured around a considerable number of letters and unpublished notes by Giovanni Domenico Cassini and his correspondents. Professor of astronomy in Bologna until 1669, royal astronomer and first courtier of Louis XIV thereafter, Cassini was called to France to give an opinion on the building under construction. He lived and worked there throughout the Great Century: his manuscripts constitute a particularly rich source for studying this institution, questioning the fundamental choices concerning it and following the evolution of its purpose.From this examination, we conclude that although other celestial observation sites have existed before, Cassini invented a new kind of organisation of pratique savante. Functioning without explicit rules, the Observatoire nevertheless greatly innovates in the organisation of collective work within an establishment dedicated to astronomical practice and in the constitution of networks of observers around the world working in a coordinated manner in pursuit of a common project at the service of the monarchy. In the thesis we show that the savant organises the Observatory around a concept that comes from his work on the Italian meridians, the esattezza of measurements and the gap between Earth and Sky. The techniques of the Observatoire will spread thanks to him: the networks of sociability of the Italian will condition the daily functioning of the establishment and the circulation of knowledge in the city and throughout the world

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Stewart, Paul Nathan. "Stellar Astrophysics With Cassini: Syzygies, Stardust, and the Sizes Of Stars." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/14517.

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The Cassini spacecraft has been exploring the complex and fascinating Saturnian system for over a decade. This thesis presents Cassini observations employed for the study of evolved stars. Utilising the on-board near-infrared spectrometer, we demonstrate the recovery of flux calibrated stellar spectra. Data were taken from a publicly-accessible archive, and the overwhelming majority were obtained for various spacecraft engineering and calibration purposes; their application to stellar astrophysics being an opportunistic extension to the mission outcomes. An atlas of stellar spectra has been compiled utilising existing observations acquired to monitor the performance of the instrument. Exploiting archival observations of stars as they are occulted by edges within Saturn’s rings, we demonstrate the recovery of stellar spatial information, specifically angular diameters, and compare these to measurements from ground-based interferometry. High-resolution two-dimensional images of stellar environments are reconstructed by tomographically combining these occultation observations from different edges within the planetary rings. An extensive astrophysical study of the evolved star Mira employing all of these techniques over multiple epochs reveals spectrally dependant molecular shells in its extended atmosphere, and allows for the appraisal of state-of-the-art models which aim to describe the atmospheres of such stars. Finally, the carbon star, IRC+10216 is shown to be embedded in a dynamic shroud of thick dusty circumstellar clouds, challenging existing models of the inner structure of the stellar environment.

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McAndrews, Hazel Joanna. "Cassini observations of low energy electrons in and around Saturn's magnetosphere." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446320/.

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The work in this thesis utilises data from the Cassini spacecraft in the analysis of the Saturnian system. Data from the electron spectrometer (ELS), the ion spectrometer (IMS) and the magnetometer (MAG) gathered during the first two years of the mission have been used in two main areas of research. The first is the investigation of the magnetopause, which forms the boundary between the region of space dominated by the planetary magnetic field and currents, and the interplanetary magnetic field. The second concerns the high energy electrons fluxes in the inner magneto sphere, and the effects caused when the icy moons carve out cavities in these populations. We find evidence strongly suggestive of reconnection events as observed at Earth at two separate encounters with the magnetopause. The energisation of the plasma, together with the open field configuration provides us with an estimate for the reconnection voltage at Saturn. It is found to, at times, be comparable to the corotation electric field, which is assumed to dominate the dynamics of the system. The large database of 200 crossings of the magnetopause is also used to derive general characteristics of the electron behaviour at this boundary. We find that boundary layer plasma is often present inside the magnetopause of Saturn, although the evidence suggests that internal plasma may play a role in formation of this layer. The ELS is able to utilise the penetration of high energy electrons directly into the detector to study the 'microsignatures' of the icy moons in the inner magnetosphere. The absorption of the high energy electrons leaves a cavity in the plasma. The subsequent re-filling over time by the surrounding plasma has allowed us to derive diffusion rates at Tethys, Enceladus and Mimas. In general, outward diffusion is faster than inward diffusion, although this varies at Enceladus.

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