Relevant bibliographies by topics / CARE DIAGNOSTICS

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'CARE DIAGNOSTICS'

Author: Grafiati
Published: 11 September 2023

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Journal articles on the topic "CARE DIAGNOSTICS"

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Rajsic, Sasa, Robert Breitkopf, Mirjam Bachler, and Benedikt Treml. "Diagnostic Modalities in Critical Care: Point-of-Care Approach." Diagnostics 11, no. 12 (November 25, 2021): 2202. http://dx.doi.org/10.3390/diagnostics11122202.

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The concept of intensive care units (ICU) has existed for almost 70 years, with outstanding development progress in the last decades. Multidisciplinary care of critically ill patients has become an integral part of every modern health care system, ensuing improved care and reduced mortality. Early recognition of severe medical and surgical illnesses, advanced prehospital care and organized immediate care in trauma centres led to a rise of ICU patients. Due to the underlying disease and its need for complex mechanical support for monitoring and treatment, it is often necessary to facilitate bed-side diagnostics. Immediate diagnostics are essential for a successful treatment of life threatening conditions, early recognition of complications and good quality of care. Management of ICU patients is incomprehensible without continuous and sophisticated monitoring, bedside ultrasonography, diverse radiologic diagnostics, blood gas analysis, coagulation and blood management, laboratory and other point-of-care (POC) diagnostic modalities. Moreover, in the time of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, particular attention is given to the POC diagnostic techniques due to additional concerns related to the risk of infection transmission, patient and healthcare workers safety and potential adverse events due to patient relocation. This review summarizes the most actual information on possible diagnostic modalities in critical care, with a special focus on the importance of point-of-care approach in the laboratory monitoring and imaging procedures.
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Drain, Paul K., and Christine Rousseau. "Point-of-care diagnostics." Current Opinion in HIV and AIDS 12, no. 2 (March 2017): 175–81. http://dx.doi.org/10.1097/coh.0000000000000351.

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Mira, Juan C., and Lyle L. Moldawer. "Sepsis Diagnostics." Critical Care Medicine 45, no. 1 (January 2017): 129–30. http://dx.doi.org/10.1097/ccm.0000000000002117.

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Bharadwaj, Mitasha, Michel Bengtson, Mirte Golverdingen, Loulotte Waling, and Cees Dekker. "Diagnosing point-of-care diagnostics for neglected tropical diseases." PLOS Neglected Tropical Diseases 15, no. 6 (June 17, 2021): e0009405. http://dx.doi.org/10.1371/journal.pntd.0009405.

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Inadequate and nonintegrated diagnostics are the Achilles’ heel of global efforts to monitor, control, and eradicate neglected tropical diseases (NTDs). While treatment is often available, NTDs are endemic among marginalized populations, due to the unavailability or inadequacy of diagnostic tests that cause empirical misdiagnoses. The need of the hour is early diagnosis at the point-of-care (PoC) of NTD patients. Here, we review the status quo of PoC diagnostic tests and practices for all of the 24 NTDs identified in the World Health Organization’s (WHO) 2021–2030 roadmap, based on their different diagnostic requirements. We discuss the capabilities and shortcomings of current diagnostic tests, identify diagnostic needs, and formulate prerequisites of relevant PoC tests. Next to technical requirements, we stress the importance of availability and awareness programs for establishing PoC tests that fit endemic resource-limited settings. Better understanding of NTD diagnostics will pave the path for setting realistic goals for healthcare in areas with minimal resources, thereby alleviating the global healthcare burden.
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Pereira, Stephen. "Early diagnostics in secondary care." Pancreatology 20, no. 8 (December 2020): e2. http://dx.doi.org/10.1016/j.pan.2018.10.015.

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Ehrenkranz, Joel. "Point-of-Care Endocrine Diagnostics." Endocrinology and Metabolism Clinics of North America 46, no. 3 (September 2017): 615–30. http://dx.doi.org/10.1016/j.ecl.2017.04.010.

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de Puig, Helena, Irene Bosch, James J. Collins, and Lee Gehrke. "Point-of-Care Devices to Detect Zika and Other Emerging Viruses." Annual Review of Biomedical Engineering 22, no. 1 (June 4, 2020): 371–86. http://dx.doi.org/10.1146/annurev-bioeng-060418-052240.

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Rapid diagnostic tests (point-of-care devices) are critical components of informed patient care and public health monitoring (surveillance applications). We propose that among the many rapid diagnostics platforms that have been tested or are in development, lateral flow immunoassays and synthetic biology–based diagnostics (including CRISPR-based diagnostics) represent the best overall options given their ease of use, scalability for manufacturing, sensitivity, and specificity. This review describes the identification of lateral flow immunoassay monoclonal antibody pairs that detect and distinguish between closely related pathogens and that are used in combination with functionalized multicolored nanoparticles and computational methods to deconvolute data. We also highlight the promise of synthetic biology–based diagnostic tests, which use synthetic genetic circuits that activate upon recognition of a pathogen-associated nucleic acid sequence, and discuss how the combined or parallel use of lateral flow immunoassays and synthetic biology tools may represent the future of scalable rapid diagnostics.
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Mashamba-Thompson, Tivani P., and Paul K. Drain. "Point-of-Care Diagnostic Services as an Integral Part of Health Services during the Novel Coronavirus 2019 Era." Diagnostics 10, no. 7 (July 3, 2020): 449. http://dx.doi.org/10.3390/diagnostics10070449.

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Point-of-care (POC) diagnostic services are commonly associated with pathology laboratory services. This issue presents a holistic approach to POC diagnostics services from a variety of disciplines including pathology, radiological and information technology as well as mobile technology and artificial intelligence. This highlights the need for transdisciplinary collaboration to ensure the efficient development and implementation of point-of-care diagnostics. The advent of the novel coronavirus 2019 (COVID-19) pandemic has prompted rapid advances in the development of new POC diagnostics. Global private and public sector agencies have significantly increased their investment in the development of POC diagnostics. There is no longer a question about the availability and accessibility of POC diagnostics. The question is “how can POC diagnostic services be integrated into health services in way that is useful and acceptable in the COVID-19 era?”.
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Demikhova, O. V., N. L. Karpina, L. N. Lepekha, M. A. Bagirov, and R. B. Amansakhedov. "OPTIMISATION OF DIAGNOSTICS AND DIFFERENTIAL DIAGNOSTICS DISSEMINATED PULMONARY TUBERCULOSIS." Annals of the Russian academy of medical sciences 67, no. 11 (November 10, 2012): 15–21. http://dx.doi.org/10.15690/vramn.v67i11.466.

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One of the reasons of dramatic situation with tuberculosis in Russia is untimely diagnostics of tuberculosis. The aim of the study was to identify the causes of diagnostic mistakes when we deal with disseminated pulmonary tuberculosis at current stage and to modernize the diagnostic process. The analysis of the diagnostic activity of the consultative diagnostic center of Central Tuberculosis Research Institute of Russian Academy Medical Sciences for 2011 was performed with special attention on the results of the survey of 505 patients with pulmonary dissemination. The frequency of discrepancies of disseminated pulmonary tuberculosis diagnostics was 96,1%. Based on the studies carried out the main causes diagnostic mistakes in patients with disseminated pulmonary tuberculosis were determined. New directions of improving of tuberculosis diagnostics were developed: overall high-technology examination of patient, adherence to the diagnostic procedure, developed by consultative diagnostic center of Central Tuberculosis Research Institute(CTRI), timely performing fiber-optic bronchoscopy with complex biopsy and diagnostic surgery procedures, further training of primary health care doctors. Implementation of proposed activities will significantly (by 3–5 times) reduce the time for diagnostics of respiratory system disease.
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Vologin, N. A. "Experience of the functional diagnostics department in an acute care hospital." Kazan medical journal 67, no. 4 (July 15, 1986): 302. http://dx.doi.org/10.17816/kazmj70556.

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The Cheboksary Emergency Medical Care Hospital has a functional diagnostics department, which includes 6 rooms: electrocardiography, phonocardiography, examination of respiratory function, central nervous system, peripheral hemodynamics and veloergometry. Establishment of the functional diagnostics department allowed to rationally use complex expensive equipment and provide round-the-clock failure-free service by functional diagnostic methods to all those in need, improve the quality of examination and reduce its duration.
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Dissertations / Theses on the topic "CARE DIAGNOSTICS"

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Horák, Josef [Verfasser], and Gerald A. [Akademischer Betreuer] Urban. "Microfluidic immunosensor for point-of-care diagnostics = Microfluidischer Immunosensor für patientennahe Diagnostik." Freiburg : Universität, 2013. http://d-nb.info/1123477787/34.

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Hyde, E., and Maryann L. Hardy. "Patient Centred Care & Considerations." CRC Press, 2020. http://hdl.handle.net/10454/18565.

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Shatova, Tatyana A. "Portable blood plasma separation for point of care diagnostics." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/103847.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2015.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 127-136).
Point of care testing is expanding the healthcare field towards personalized and early-detection medicine. Microfluidic platforms present an opportunity for low cost, portable diagnostic sensors through manipulation of small volumes of fluids on isolated, compact devices. One of the challenges of microfluidic sensors is the biological sample pretreatment steps that are manually performed prior to on-chip loading and sensing. This issue is especially prominent for human blood, which contains about a billion cells in one milliliter total volume. These blood cells can rupture, clog devices, block optical readouts, and foul electrodes. At the same time, the liquid portion of human blood, plasma, is rich in a variety of disease indicators, many of which have not yet been identified, and thus is an essential part in the diagnostic field. This thesis focuses on the design of a small, around 1 cm long, microfluidic device that separates out blood plasma from undiluted human blood. This design does not require any external field or equipment, beyond a loading syringe and collection tubing. The separation results show 10-100 times improvement in plasma purity over the literature values for passive separation designs. This separation system was then combined with a colorimetric malaria sensor that produced a visually detectable colored result with a 7.5 nM limit of detection in whole blood. This thesis details the design of a low power point of care diagnostic process that is capable of blood processing and detection, and which eliminates the need for any external laboratory-scale equipment. Advantages and challenges of other low power, microfluidic sensor constructs are also discussed.
by Tatyana A. Shatova.
Ph. D.
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Chaychian, Sara. "Magnetic DNA detection sensor for point-of-care diagnostics." Thesis, Brunel University, 2014. http://bura.brunel.ac.uk/handle/2438/11496.

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This thesis focuses on inductive base sensor design at MHz range frequency. The background theory, design, experiments and results for a new magnetic particles sensor is presented. A new magnetic sensor based on a planar coil was investigated for DNA pathogen detection. Change in inductance of the planar coil due to the presence of magnetic particles with varying mass was measured. The experimental set-up consisted of different sized planar coil with associated electronics for inductance measurements. The best sensor performance was accomplished using two different inductors while oscillating at frequencies 2.4MHz using 9.5μH inductor and 7.2MHz with 85μH inductor. The sensor has very large signal to noise ratio (580×103), while the average amount of frequency drift was 0.58. This sensor was tested with various types of magnetic particles. In addition, iron-oxide nanoparticles were synthesized through water in oil microemulsion method and with an average size of 25nm. The best sensitivity achieved for detection of 50μg iron-oxide particles was with the bead size of 10nm. 81Hz frequency shift was attained in regard to that amount of particles. This research shows that increasing the resonance frequency to 7.2MHz can cause the larger output signal difference (frequency shift) in the presence of magnetic particles; however, the sensor stability is the most important factor for determining the detection resolution and sensitivity. The sensitivity is better if the sensor can detect smaller amount of magnetic sample. The results of this research demonstrate that while the sample consists of smaller size particles, the sensor can detect the lower amount of sample. This is due to the heating effect of nanoparticles. On the other hand the sample distance from the sensor has a major impact on the sensitivity too; the shorter the distance, the higher the sensitivity. This technique can potentially be extended to detect several different types of bacterial pathogens and can be modified for multiplex quantitative detection. This sensing technique will be incorporated into a handheld, disposable microfluidic chip for point-of-care diagnostics for sexually transmitted diseases.
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Kao, Linus Tzu-Hsiang. "Point-of-Care Body Fluid Diagnostics in Microliter Samples." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1238692368.

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Ereku, Luck Tosan. "Design of microfluidic multiplex cartridge for point of care diagnostics." Thesis, Brunel University, 2017. http://bura.brunel.ac.uk/handle/2438/15331.

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A simple, but innovative microfluidic Lab-on-a-chip (LOC) device which is broadly applicable in point of care diagnostics of biological pathogens was designed, fabricated and assembled utilising explicit microfluidic techniques. The purpose of this design was to develop a cartridge with the capability to perform multiplex DNA amplification reactions on a single device. To achieve this outcome, conventional laboratory protocols for sample preparation; involving DNA extraction, purification and elution were miniaturized to suit this lab-on-a-chip device of 75mm X 50mm cross-sectional area. The extraction process was carried out in a uniquely designed microchamber embedded with chitosan membrane that binds DNA at pH 5.0 and elutes when a different solution at pH 9.0 flows through. Likewise, purification protocol that occurs in the designed waste reservoir is very significant in biomedical field because it is concerned with waste treatment and cartridge disposability, was performed with a super absorbent powder that converts liquid to a gel like substance. This powder is known as sodium polyacrylate, which is also they treated with anti-bacterial chemicals to prevent environmental contamination. Furthermore, this process also employed the use of a passive valve for a precise fluid handling operation involving flow regulation from extraction to waste reservoir. In order to achieve the intended multiplexing function a multiplexer was created to distribute flow simultaneously through a bifurcated network of channels connected to six similar amplification microchambers. Prior to fabrication, computational fluid dynamics (CFD) simulation was utilized at flowrates less than 10μL/s as the means to test the effectiveness of each design components and also to specifically deduct empirical values that can be analyzed to improve or understand the relationship between the fluid and geometrical constraints of the microfluidic modular elements. The device produced was a hybrid cartridge composed of PDMS and glass which is the most widely used materials microfluidics research due to their low cost and simplicity of fabrication by soft lithography technique. The choice of material also took into account the various physical and chemical properties advantages and disadvantages in their bio-medical applications. Such properties include but not limited to surface energy that determines the wetting fluid characteristics, biocompatibility, optical transparency. Subsequently, after a prototype cartridge was developed fluid flow experimentation using liquid coloured dye was used on the fully fabricated cartridge to test the efficacy of its microfluidic functionalities before expensive DNA amplification reagents were utilised at similar flowrates to the CFD simulations. This gave rise to comparison between similar and dissimilar flow Peculiarities in the microfluidic circuit of both experiments. The final experiment was performed with the aid of a recent molecular technique in DNA amplification known as of RPA kit (recombinase polymerase amplification reaction). It involved performing two main reaction experiments; first, was the positive experiment that bears the sample DNA and the latter, negative that served as the control without DNA. In the end, quantitative analysis of results was done using an agarose gel that showed 143 base pairs, for the positive samples, thus validating the amplification experiment.
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Lathwal, Shefali. "Application of polymerization-based amplification in point-of-care diagnostics." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104209.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 129-134).
Diagnostic tests in resource-limited settings require technologies that are affordable and easy-to-use with minimal infrastructure. Colorimetric detection methods that provide results that are readable by eye, without reliance on specialized and expensive equipment, have great utility in these settings. Existing colorimetric methods based on enzymatic reactions and gold nanoparticles often produce results that must be read within a specified time interval to ensure their validity. In many instances, a user has to wait several minutes for the color to develop. Moreover, the result can be interpreted incorrectly because of low visual contrast. Therefore, a colorimetric detection technology that produces bright and unambiguous readout within a time interval of a few seconds to less than two minutes, and removes the burden of accurate time keeping from the user can be very beneficial in low-resource settings. Photo-initiated polymerization-based amplification (PBA) is a technology that allows detection of a surface-bound analyte through co-localization of a visible-light photoinitiator with the analyte present on the surface. In the presence of an appropriate dose of light and monomers, a subsequent free radical polymerization reaction results in formation of an interfacial hydrogel in areas where the initiator has been localized. In this thesis, we modified the eosin/tertiary amine-based PBA technology, which had previously been developed on transparent glass surfaces, for use with cellulose-based (paper) surfaces. Using Plasmodium falciparum histidine-rich protein as an example, we showed that paper-based PBA allowed high-contrast visual detection of proteins with a limit-of-detection of single digit nM concentration (~7 nM) in complex matrices such as human serum and plasma purified from blood samples through the use of a hand-operated microfluidic device. The paper-based immunoassay required only 10 [mu]L sample per test and the total time for signal amplification, from illumination to colorimetric detection, was 2-2.5 minutes per test. The method provided quantitative information regarding analyte levels when combined with cellphone-based imaging. It also allowed decoupling of the capture of analyte on the surface from the signal amplification and visualization steps. We showed that in comparison with enzymatic amplification methods and silver deposition on gold nanoparticles, PBA-based readout on paper was cheaper, easier to perceive at its limit-of-detection, and had the lowest incidence of false readouts due to timing errors. In addition to developing PBA for use in paper devices, we combined PBA with a dilution array approach for quantifying analyte levels by counting number of visible polymer spots on a biochip. We used an empirical design approach that did not depend on measurement of equilibrium and kinetic binding parameters of the antibodies used in the assay and provided a dynamic range of three orders of magnitude, 70 pM to 70 nM, for visual quantification of the analyte. We also built a portable, light-weight, and customizable LED-based device with automated timer functionality for use with PBA assays in point-of-care settings.
by Shefali Lathwal.
Ph. D.
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Yetisen, Ali Kemal. "Holographic point-of-care diagnostic devices." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/246754.

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Developing non-invasive and accurate diagnostics that are easily manufactured, robust and reusable will provide monitoring of high-risk individuals in any clinical or point-of-care environment, particularly in the developing world. There is currently no rapid, low-cost and generic sensor fabrication technique capable of producing narrow-band, uniform, reversible colorimetric readouts with a high-tuneability range. This thesis aims to present a theoretical and experimental basis for the rapid fabrication, optimisation and testing of holographic sensors for the quantification of pH, organic solvents, metal cations, and glucose in solutions. The sensing mechanism was computationally modelled to optimise its optical characteristics and predict the readouts. A single pulse of a laser (6 ns, 532 nm, 350 mJ) in holographic “Denisyuk” reflection mode allowed rapid production of sensors through silver-halide chemistry, in situ particle size reduction and photopolymerisation. The fabricated sensors consisted of off-axis Bragg diffraction gratings of ordered silver nanoparticles and localised refractive index changes in poly(2-hydroxyethyl methacrylate) and polyacrylamide films. The sensors exhibited reversible Bragg peak shifts, and diffracted the spectrum of narrow-band light over the wavelength range λpeak ≈ 500-1100 nm. The application of the holographic sensors was demonstrated by sensing pH in artificial urine over the physiological range (4.5-9.0), with a sensitivity of 48 nm/pH unit between pH 5.0 and 6.0. For sensing metal cations, a porphyrin derivative was synthesised to act as the crosslinker, the light absorbing material, the component of a diffraction grating, as well as the cation chelating agent. The sensor allowed reversible quantification of Cu2+ and Fe2+ ions (50 mM - 1 M) with a response time within 50 s. Clinical trials of a glucose sensor in the urine samples of diabetic patients demonstrated that the glucose sensor has an improved performance compared to a commercial high-throughput urinalysis device. The experimental sensitivity of the glucose sensor exhibited a limit of detection of 90 µM, and permitted diagnosis of glucosuria up to 350 mM. The sensor response was achieved within 5 min and the sensor could be reused about 400 times without compromising its accuracy. Holographic sensors were also tested in flake form, and integrated with paper-iron oxide composites, dyed filter and chromatography papers, and nitrocellulose-based test strips. Finally, a generic smartphone application was developed and tested to quantify colorimetric tests for both Android and iOS operating systems. The developed sensing platform and the smartphone application have implications for the development of low-cost, reusable and equipment-free point-of-care diagnostic devices.
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Newton, L. A. A. "The development of novel electroanalytical interfaces for point of care diagnostics." Thesis, Nottingham Trent University, 2012. http://irep.ntu.ac.uk/id/eprint/355/.

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Reduced sulphydryl thiols (RSH): cysteine, homocysteine and glutathione are fundamental cellular components having important biological functions, including roles within the pathogenesis of a variety of clinical conditions. Independent analysis of these species is problematic and analytical difficulties relating to instrumental selectivity and sensitivity need to be overcome. This thesis describes the work carried out on the development and characterisation of a range of systems that could be used to facilitate thiol detection, ideally at the point-of-care, focussing largely on electrochemical techniques. Silver-thiol interactions were studied as a route to assist the sample processing. Here a novel controlled silver release mechanism was assessed. Silver release was found to be dependent upon the thiol structure. This has possible future applications to the development of methods to prevent biofilm formation, although the full mechanism of silver-thiol release requires further understanding. The development of unique molecular imprinted polymers was attempted. These would facilitate the detection of amino acids and the relevant thiol species via the amine functionality. The polymers proved unstable in the presence of hydroxylamine. However, this property makes the polymers suitable for use as protective or sacrificial polymers which can potentially be exploited in the manufacture of patterned electrodes. The nucleophilic substitution reaction between thiols and quinones, or quinone type materials, was explored as a possible route to assist selective thiol detection via electrochemical or colorimetric methods. Development of such reagentless sensing platforms would be beneficial in clinical analysis. Selectivity of thiol determination was achieved, although sensitivity issues will restrict real-world applications. A pH sensor utilising uric acid redox sensitivity was developed and was integrated within a disposable electrode assembly to enable wound pH monitoring. This platform was adapted as a prototype generic sensor for thiol analysis.
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Pappa, Anna maria. "Metabolite detection using organic electronic devices for point-of-care diagnostics." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEM020/document.

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De nos jours, efficacité et précision des diagnostics médicaux sont des éléments essentiels pour la prévention en termes de santé et permettre une prise en charge rapide des maladies des patients. Les récentes innovations technologiques, particulièrement dans les domaines de la microélectronique et des sciences des matériaux ont permis le développement de nouvelles plateformes personnalisées de diagnostics portatifs. Les matériaux électroniques organiques qui ont déjà par le passé démontré leur potentiel en étant intégrés dans des produits de grande consommation tels que les écrans de smartphones ou encore les cellules solaires montrent un fort potentiel pour une intégration dans des dispositifs biomédicaux. En effet, de par leurs natures et leurs propriétés physiques et chimiques, ils peuvent être à la fois en contact avec les milieux biologiques et constituer l’interface entre les éléments biologiques à l’étude, et les dispositifs électroniques. L’objectif de mes travaux de thèse et d’étudier et évaluer les performances des matériaux organiques électroniques intégrés dans des dispositifs biomédicaux en étudiant leurs interactions avec des milieux biologiques et par l’utilisation et l’optimisation de ces dispositifs permettre la détection de métabolites tel que le glucose ou lactate par exemple. Pendant ma thèse, j’ai notamment créé une plateforme de diagnostics combinant à la fois microfluidique et électronique organique permettant la multi détection de métabolites présents dans des fluides corporels humains, j’ai également conçu des capteurs intégrant des transistors organiques au sein des circuits électroniques classiques afin de détecter la présence des cellules tumorales. D’autres applications biologiques ont également été envisagées telles que la détection d’acides nucléiques par l’utilisation d’une approche simple de biofonctionnalisation. Bien que l’objectif ma thèse était de de créer des capteurs biomédicaux en utilisant une approche in vitro, il pourrait être également possible d’intégrer ces dispositifs « in vivo » ou encore dans des e-textiles
Rapid and early diagnosis of disease plays a major role in preventative healthcare. Undoubtedly, technological evolutions, particularly in microelectronics and materials science, have made the hitherto utopian scenario of portable, point-of-care personalized diagnostics a reality. Organic electronic materials, having already demonstrated a significant technological maturity with the development of high tech products such as displays for smartphones or portable solar cells, have emerged as especially promising candidates for biomedical applications. Their soft and fuzzy nature allows for an almost seamless interface with the biological milieu rendering these materials ideally capable of bridging the gap between electronics and biology. The aim of this thesis is to explore and validate the capabilities of organic electronic materials and devices in real-world biological sensing applications focusing on metabolite sensing, by combining both the right materials and device engineering. We show proof-of-concept studies including microfluidic integrated organic electronic platforms for multiple metabolite detection in bodily fluids, as well as more complex organic transistor circuits for detection in tumor cell cultures. We finally show the versatility of organic electronic materials and devices by demonstrating other sensing strategies such as nucleic acid detection using a simple biofunctionalization approach. Although the focus is on in vitro metabolite monitoring, the findings generated throughout this work can be extended to a variety of other sensing strategies as well as to applications including on body (wearable) or even in vivo sensing
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Books on the topic "CARE DIAGNOSTICS"

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Khan, Raju, Chetna Dhand, S. K. Sanghi, Shabi Thankaraj Salammal, and A. B. P. Mishra. Advanced Microfluidics-Based Point-of-Care Diagnostics. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003033479.

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Issadore, David, and Robert M. Westervelt, eds. Point-of-Care Diagnostics on a Chip. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-29268-2.

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Gogoi, Manashjit, Sanjukta Patra, and Debasree Kundu, eds. Nanobiosensors for point-of-care medical diagnostics. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-5141-1.

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Insight, LLC Medtech. U.S. markets for point-of-care diagnostics. Newport Beach, CA: Medtech Insight, 2003.

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Verhagen, Arianne, and Jeroen Alessie. Evidence based diagnostics of musculoskeletal disorders in primary care. Houten: Bohn Stafleu van Loghum, 2018. http://dx.doi.org/10.1007/978-90-368-2146-9.

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Dutta, Gorachand, ed. Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-7130-3.

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Inc, Medical Data International. U.S. markets for point-of-care diagnostics, 1999-2004. Santa Ana, Calif: Medical Data International, 1999.

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Acharya, Amitabha, and Nitin Kumar Singhal, eds. Nanosensors for Point-of-Care Diagnostics of Pathogenic Bacteria. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-1218-6.

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Differential diagnosis in primary care. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2012.

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1947-, Moorhouse Mary Frances, and Murr Alice C. 1946-, eds. Diagnostics infirmiers: Interventions et justifications. 6th ed. Saint-Laurent, Québec: ERPI, 2012.

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Book chapters on the topic "CARE DIAGNOSTICS"

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Peetz, Dirk, Jürgen Koszielny, and Michael Spannagl. "Coagulation diagnostics." In Point-of-Care Testing, 145–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54497-6_15.

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Kixmüller, Dorthe, Norbert Gässler, and Ralf Junker. "Hematological diagnostics." In Point-of-Care Testing, 155–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54497-6_16.

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Yetisen, Ali Kemal. "Point-of-Care Diagnostics." In Holographic Sensors, 1–25. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-13584-7_1.

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Bier, Frank F., and Soeren Schumacher. "Integration in Bioanalysis: Technologies for Point-of-Care Testing." In Molecular Diagnostics, 1–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/10_2012_164.

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Adams, Frauke, Jörg-M. Hollidt, and Christof Winter. "Companion diagnostics and liquid biopsy." In Point-of-Care Testing, 433–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54497-6_43.

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Bala, Miklosh, and Fausto Catena. "Auxiliary Clinical Diagnostics." In Hot Topics in Acute Care Surgery and Trauma, 91–99. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-92345-1_8.

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Kulinsky, Lawrence, Zahra Noroozi, and Marc Madou. "Present Technology and Future Trends in Point-of-Care Microfluidic Diagnostics." In Microfluidic Diagnostics, 3–23. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-134-9_1.

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Fielding, C. Langdon. "Point-of-Care Testing." In Interpretation of Equine Laboratory Diagnostics, 23–26. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118922798.ch3.

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Debnath, Mousumi, Godavarthi B. K. S. Prasad, and Prakash S. Bisen. "Biopharmaceutical Industry and Health Care." In Molecular Diagnostics: Promises and Possibilities, 413–24. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3261-4_24.

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Ezoji, Hoda, and Mostafa Rahimnejad. "Nanobiomaterials for Point-of-Care Diagnostics." In Handbook of Nanobioelectrochemistry, 43–68. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9437-1_3.

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Conference papers on the topic "CARE DIAGNOSTICS"

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Homola, Jiří, Marketa Bockova, Tomas Springer, and Jiri Slaby. "Plasmonic biosensors for medical diagnostics." In Biophotonics in Point-of-Care II, edited by Michael T. Canva, Ambra Giannetti, Julien Moreau, and Hatice Altug. SPIE, 2022. http://dx.doi.org/10.1117/12.2630949.

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van Klinken, Anne, R. Jansen, A. Hendriks, C. Li, M. Dolci, P. Sevo, L. Picelli, M. S. Cano, P. Zijlstra, and Andrea Fiore. "Integrated spectral interrogator for point-of-care biosensors." In Optical Diagnostics and Sensing XXIII: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2023. http://dx.doi.org/10.1117/12.2649821.

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Choi, Honggu, Chun-Li Chang, Cagri Savran, and David Nolte. "Diffraction-based BioCD biosensor for point-of-care diagnostics." In Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2018. http://dx.doi.org/10.1117/12.2291069.

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Dryden, Simon, Salzitsa Anastasova, Giovanni Satta, Alex J. Thompson, Daniel R. Leff, and Ara W. Darzi. "Toward point-of-care uropathogen detection using SERS active filters." In Optical Diagnostics and Sensing XX: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2020. http://dx.doi.org/10.1117/12.2545515.

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Jaitpal, Siddhant, Suhash Chavva, and Samuel Mabbott. "Towards point-of-care detection of microRNAs using paper-based microfluidics." In Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2021. http://dx.doi.org/10.1117/12.2589180.

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Dochow, Sebastian. "Miniaturized, high performance microscopes for point-of-care applications (Conference Presentation)." In Optical Diagnostics and Sensing XXIII: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2023. http://dx.doi.org/10.1117/12.2651438.

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Harris, Georgia, Carl Banbury, Michael T. Clancy, Neil Eisenstein, Iain B. Styles, Ann Logan, Antonio Belli, and Pola Goldberg Oppenheimer. "Portable and Eye-Safe Raman Spectroscopy for Point-of-Care Neurological Diagnostics." In Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2022. http://dx.doi.org/10.1117/12.2608249.

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"Front Matter: Volume 10501." In Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2018. http://dx.doi.org/10.1117/12.2323027.

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Le Cardinal de Kernier, Isaure, Stéphanie Bressieux, Nelly Rongeat, Anaïs Ali-Chérif, Sophie Morales, Serge Monneret, and Pierre Blandin. "Statistical study of blood cell populations by very wide-field bimodal phase/ fluorescence imaging." In Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2019. http://dx.doi.org/10.1117/12.2506531.

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Shadgan, Babak, Allan Fong, Neda Manouchehri, Kitty So, Katelyn Shortt, Femke Streijger, Andrew Macnab, and Brian Kwon. "Changes of mean arterial pressure affect spinal cord oxygenation as monitored by an implantable near-infrared spectroscopy sensor in an animal model of acute spinal cord injury (Conference Presentation)." In Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2019. http://dx.doi.org/10.1117/12.2506715.

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Reports on the topic "CARE DIAGNOSTICS"

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Lau, J., and B. Baker. Isothermal DNA Assay to Detect Drug-Resistant Tuberculosis for Point-of-Care Diagnostics. Office of Scientific and Technical Information (OSTI), August 2013. http://dx.doi.org/10.2172/1093910.

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Mukundan, Harshini. The Microbe Strikes Back: Emerging infectious Diseases and the need for point of care diagnostics. Office of Scientific and Technical Information (OSTI), November 2018. http://dx.doi.org/10.2172/1481963.

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DiFatta, Chas, and Mark Poepping. The Case for Comprehensive Diagnostics. Internet2, May 2005. http://dx.doi.org/10.26869/ti.12.1.

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Regan, J., S. Letant, K. Adams, R. Mahnke, N. Nguyen, J. Dzenitis, B. Hindson, et al. A Multiplexed Diagnostic Platform for Point-of-Care Pathogen Detection. Office of Scientific and Technical Information (OSTI), February 2008. http://dx.doi.org/10.2172/926006.

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Galasso, Alberto, and Hong Luo. Risk-Mitigating Technologies: the Case of Radiation Diagnostic Devices. Cambridge, MA: National Bureau of Economic Research, September 2019. http://dx.doi.org/10.3386/w26305.

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Ciapponi, Agustín. Do midlevel dental providers improve oral health? SUPPORT, 2017. http://dx.doi.org/10.30846/1702132.

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Access to dental care and dentists is difficult around the world, particularly in low- income countries. Consequently, many nations have employed alternative non dentist midlevel providers to conduct diagnostic, treatment planning, or irreversible surgical dental procedures.
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Harrington, Cherise B. Patterns of diagnostic care in nonspecific low back pain: Relation to patient satisfaction and perceived health. Fort Belvoir, VA: Defense Technical Information Center, November 2006. http://dx.doi.org/10.21236/ad1013990.

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Pai, Menaka, Allan Grill, Noah Ivers, Antonina Maltsev, Katherine J. Miller, Fahad Razak, Michael Schull, et al. Vaccine Induced Prothrombotic Immune Thrombocytopenia (VIPIT) Following AstraZeneca COVID-19 Vaccination. Ontario COVID-19 Science Advisory Table, March 2021. http://dx.doi.org/10.47326/ocsat.2021.02.17.1.0.

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This Science Brief provides information for health care professionals about Vaccine Induced Prothrombotic Immune Thrombocytopenia (VIPIT), a rare adverse event following the AstraZeneca vaccine. This brief describes the pathophysiology, presentation, diagnostic work-up and treatment of VIPIT. Figure 1 presents a decision tree for diagnosis and rule out of VIPIT.
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Hamilton, Carolyn. Review and Recommendations for Strengthening Transitioning-from-State-Care Services for Youth in the Protection System. Inter-American Development Bank, July 2022. http://dx.doi.org/10.18235/0004354.

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Research studies from a range of countries indicate that, despite differences in policies, youth who age out of state care have significant similarities in outcomes globally. These young people have difficulty finding stable and affordable housing; accessing a social network, healthcare, and supportive and safe social relationships; and engaging in education, training, and employment. The present report, focused on youth aging out of residential care and detention in Belize, aims to contribute to the growing literature on frameworks, models, programs, and best practices to address service gaps and barriers and improve outcomes for youth transitioning to post care. The report presents a diagnostic of available services to support youth in Belize to successfully transition to post-care and provides recommendations to strengthen services that improve their post-care outcomes.
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Bosart, Lance F., and Daniel Keyser. Observational Case Studies and Diagnostic Analyses of Long-Lived Large-Amplitude Inertia-Gravity Waves. Fort Belvoir, VA: Defense Technical Information Center, December 1996. http://dx.doi.org/10.21236/ada329684.

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