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Relevant bibliographies by topics / Cardiovascular system – Diseases – Treatment

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Academic literature on the topic 'Cardiovascular system – Diseases – Treatment'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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Journal articles on the topic "Cardiovascular system – Diseases – Treatment"

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Gupta, Purnima, Evelyn Garcia, Amrita Sarkar, Sumit Kapoor, Khadija Rafiq, Hitendra S. Chand, and Rahul Dev Jayant. "Nanoparticle Based Treatment for Cardiovascular Diseases." Cardiovascular & Hematological Disorders-Drug Targets 19, no. 1 (January 28, 2019): 33–44. http://dx.doi.org/10.2174/1871529x18666180508113253.

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Nanotechnology has gained increased attention for delivering therapeutic agents effectively to the cardiovascular system. Heart targeted nanocarrier based drug delivery is a new, effective and efficacious approach for treating various cardiac related disorders such as atherosclerosis, hypertension, and myocardial infarction. Nanocarrier based drug delivery system circumvents the problems associated with conventional drug delivery systems, including their nonspecificity, severe side effects and damage to the normal cells. Modification of physicochemical properties of nanocarriers such as size, shape and surface modifications can immensely alter its invivo pharmacokinetic and pharmacodynamic data and will provide better treatment strategy. Several nanocarriers such as lipid, phospholipid nanoparticles have been developed for delivering drugs to the target sites within the heart. This review summarizes and increases the understanding of the advanced nanosized drug delivery systems for treating cardiovascular disorders with the promising use of nanotechnology.

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Jastrzębska, Marta, Michael E. Czok, and Przemysław Guzik. "Autoimmune diseases, their pharmacological treatment and the cardiovascular system." Cardiology Journal 20, no. 6 (December 11, 2013): 569–76. http://dx.doi.org/10.5603/cj.2013.0156.

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Cambón, Adriana, Lilia Arellano, Eva Villar-Álvarez, Xaniar Smailzadeh, Silvia Barbosa Fernández, and Pablo Taboada Antelo. "New Approach for Cardiovascular Diseases (CVD) Treatment." Materials Proceedings 4, no. 1 (November 12, 2020): 19. http://dx.doi.org/10.3390/iocn2020-07993.

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Cardiovascular disease (CVD) is a general term that includes diseases that affect the circulatory system and/or the heart. Their underlying pathology is atherosclerosis, an inflammatory disease characterized by the accumulation of lipids, inflammatory cells and fibrous tissue in the arteries' internal wall, provoking to some extent their obstruction. Atherosclerosis is still addressed as a simple disease instead of the complex interplay of different types of cells and cascade signaling pathways, so the use of any single imaging or therapeutic agent alone is unlikely to provide a satisfactory outcome. Hence, other treatment strategies need to be implemented, in particular, those using new nanomaterials able to target the plaque and to efficiently treat it, and that can be easily released by the body without provoking adverse effects. With this background, we have designed a biocompatible drug delivery vehicle that efficiently loads and protects the drug Atorvastatin (ATO reduces the LDL levels) while a folate receptor in the external shell targets inflamed areas. To avoid the common toxic effects of folic acid (FA) or ATO in the body at certain concentrations, the vehicle will provide covalent attachment for the FA on the surface and cage structure for ATO protection. To complement the treatment, genetic material will be included in a separate compartment to actively influence the regulation of immune responses and inflammatory disorders.

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Volpe, Massimo, Speranza Rubattu, and Allegra Battistoni. "ARNi: A Novel Approach to Counteract Cardiovascular Diseases." International Journal of Molecular Sciences 20, no. 9 (April 28, 2019): 2092. http://dx.doi.org/10.3390/ijms20092092.

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Cardiovascular diseases (CVDs) still represent the greatest burden on healthcare systems worldwide. Despite the enormous efforts over the last twenty years to limit the spread of cardiovascular risk factors, their prevalence is growing and control is still suboptimal. Therefore, the availability of new therapeutic tools that may interfere with different pathophysiological pathways to slow the establishment of clinical CVDs is important. Previously, the inhibition of neurohormonal systems, namely the renin–angiotensin–aldosterone system (RAAS) and the sympathetic nervous system, has proven to be useful in the treatment of many CVDs. Attempts have recently been made to target an additional hormonal system, that of the natriuretic peptides (NPs), which, when dysregulated, can also play a role in the development CVDs. Indeed, a new class of drug, the angiotensin receptor–neprilysin inhibitors (ARNi), has the ability to counteract the effects of angiotensin II as well as to increase the activity of NPs. ARNi have already been proven to be effective in the treatment of heart failure with reduced ejection fraction. New evidence has suggested that, in the next years, the field of ARNi application will widen to include other CVDs, such as heart failure, with preserved ejection fraction and hypertension.

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Sun, Siyu, Qinhui Tuo, Dongxu Li, Xiulong Wang, Xuefang Li, Yiyue Zhang, Guoan Zhao, and Fei Lin. "Antioxidant Effects of Salidroside in the Cardiovascular System." Evidence-Based Complementary and Alternative Medicine 2020 (September 26, 2020): 1–9. http://dx.doi.org/10.1155/2020/9568647.

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Cardiovascular disease is one of the main human health risks, and the incidence is increasing. Salidroside is an important bioactive component of Rhodiola rosea L., which is used to treat Alzheimer’s disease, tumor, depression, and other diseases. Recent studies have shown that salidroside has therapeutic effects, to some degree, in cardiovascular diseases via an antioxidative mechanism. However, evidence-based clinical data supporting the effectiveness of salidroside in the treatment of cardiovascular diseases are limited. In this review, we discuss the effects of salidroside on cardiovascular risk factors and cardiovascular diseases and highlight potential antioxidant therapeutic strategies.

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Diaconu, Camelia Cristina, Ana Maria Alexandra Stanescu, Anca Pantea Stoian, Radu Ciprian Tincu, Cristian Cobilinschi, Razvan Ion Florin Dragomirescu, Bogdan Socea, et al. "Hyperkalemia and Cardiovascular Diseases: New Molecules for the Treatment." Revista de Chimie 69, no. 6 (July 15, 2018): 1367–70. http://dx.doi.org/10.37358/rc.18.6.6326.

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Potassium is a key electrolyte for the maintenance of cardiovascular system health, being involved in a broad array of vital physiological processes. Hyperkalemia is a common clinical problem and potentially life-threatening condition predominantly seen in patients with cardiac and kidney disease, especially if receiving treatment with inhibitors of the renin-angiotensin-aldosterone axis. Several studies have demonstrated the short and long-term morbidity and mortality that hyperkalemia induces in patients with cardiovascular diseases. Plenty of data is currently emerging on this topic. This paper aims to review the new strategies and molecules for improving the management of hyperkalemia.

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Li, Shuzhen, Bingyu Yang, Yang Du, Yurui Lin, Jiaqi Liu, Songming Huang, Aihua Zhang, Zhanjun Jia, and Yue Zhang. "Targeting PPARα for the Treatment and Understanding of Cardiovascular Diseases." Cellular Physiology and Biochemistry 51, no. 6 (2018): 2760–75. http://dx.doi.org/10.1159/000495969.

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Three members of the peroxisome proliferator-activated receptor (PPAR) family, PPARα, PPARγ, and PPARβ/δ, have been investigated widely over the past few decades. Although the roles of these PPARs and their agonists/antagonists were defined in clinical and basic studies, the conflicting results from these studies indicate that more analysis is needed to understand the roles of PPARs. PPARα is a ligand-activated transcription factor that contributes to the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. In this review, we focus on the function and mechanisms of PPARα in the cardiovascular system under various pathological conditions, including vascular and heart injury, blood pressure regulation, and lipid disorder-related cardiovascular injury, as well as its polymorphisms and pharmacogenetic associations with cardiovascular diseases. The anti-inflammatory effect of PPARα in cardiovascular injury is mainly through inhibition of pro-inflammatory signaling pathways and improvement of the lipid profile. Moreover, PPARα also modulates the activity of endothelial nitric oxide synthase and resets the renin-angiotensin system to regulate vascular tone. PPARα gene variants appear to be associated with some cardiovascular risk factors, such as higher plasma lipid levels, cardiac growth, and increased risk of coronary artery disease. Nowadays, novel PPARα drugs with broad safety margins and therapeutic potential for metabolic syndrome and cardiovascular diseases are being developed and applied in the clinical setting. The insights from the current review shed new light on areas of further study and provide a better understanding of the role of PPARα in cardiovascular diseases.

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Fan, Mingqiang, Xiangxiang Yang, Tao Ding, Yu Cao, Qiaoke Si, Jing Bai, Yongchun Lin, and Xinke Zhao. "Application of Ultrasound Virtual Reality in the Diagnosis and Treatment of Cardiovascular Diseases." Journal of Healthcare Engineering 2021 (August 17, 2021): 1–10. http://dx.doi.org/10.1155/2021/9999654.

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Cardiovascular disease is a common chronic disease in the medical field, which has a great impact on the health of Chinese residents (especially the elderly). At present, the effectiveness of the prevention and treatment of cardiovascular diseases in my country is not optimistic. Overall, the prevalence and mortality of CVD are still on the rise. The timely and effective detection and treatment of cardiovascular and cerebrovascular diseases are of great practical significance to improve the health of residents and to carry out prevention and treatment. This article aims to study the application of ultrasound-based virtual reality technology in the diagnosis and treatment of cardiovascular diseases to improve the efficiency and accuracy of the diagnosis of cardiovascular and cerebrovascular diseases by medical staff. The focus is on the application of feature attribute selection related algorithms and classification related algorithms in medical and health diagnosis systems, and a cardiovascular and cerebrovascular disease diagnosis system based on naive Bayes algorithm and improved genetic algorithm is designed and developed. The system builds a diagnostic model for cardiovascular and cerebrovascular diseases and diagnoses and displays the corresponding results based on the patient’s examination data. This paper first puts forward the theoretical concepts of ultrasonic virtual reality technology, scientific computing visualization, genetic algorithm, naive Bayes algorithm, and surgery simulation system and describes them in detail. Then, we construct a three-dimensional ultrasonic virtual measurement system, from the collection and reconstruction of image data to the filtering and segmentation of image data, plus the application of three-dimensional visualization and virtual reality technology to construct a three-dimensional measurement system. The experimental results in this paper show that 10 isolated congenital heart disease models with atrial septal defect (ASD) established through the use of three-dimensional visualization and virtual reality technology measured the short diameter, long diameter, and area of the atrial septal defect in the left and right atria. Finally, a value of L less than 0.05 indicates that the statistics are meaningful, and a value of r generally greater than 0.9 indicates that the virtual measurement result is highly correlated with the real measurement result.

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Chaulin, Aleksey M., and Dmitry V. Duplyakov. "Environmental factors and cardiovascular diseases." Hygiene and sanitation 100, no. 3 (April 16, 2021): 223–28. http://dx.doi.org/10.47470/0016-9900-2021-100-3-223-228.

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Introduction. New advances in the diagnosis and treatment of cardiovascular diseases (CVD), as practice shows, are not able to significantly improve the statistical indicators of morbidity and mortality of CVD. This fact indicates that there are additional factors and mechanisms that are important to consider, both for prevention and for the most optimal management of patients. Recently, the relationship between environmental and lifestyle factors with CVD has been actively studied. However, despite understanding the relationship between environmental factors and various diseases, including CVD, the mechanisms by which specific factors increase or decrease the risk of developing CVD are not yet fully understood, and a number of studies are contradictory. The aim of our work was to generalize existing data on the impact of such critical environmental factors as air pollution and solar insolation on the cardiovascular system, as well as to comprehensively discuss the mechanisms by which these environmental factors can participate in the development and progression of CVD. To achieve our work’s goal, we analyzed modern foreign literature using the PubMed database. Conclusion. According to numerous experimental and clinical studies, air pollution and solar insolation deficiency play an essential role in developing CVD and the aggravation of patients with various CVD (atherosclerosis, hypertension, coronary heart disease, heart failure, myocardial infarction, and stroke). Thus, air pollution and lack of solar insolation can be considered as critical risk factors for CVD. Future research should focus on the study and establishment of specific pathogenetic mechanisms by which environmental factors affect the cardiovascular system’s health to develop effective treatment and prevention measures.

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Wang, Yifei, Shi Zhou, Shuai Lei, Liying Hao, Deri Sun, and Huiyuan Hu. "Vitamin D Deficiency and Cardiovascular Diseases." Science of Advanced Materials 12, no. 1 (January 1, 2020): 27–37. http://dx.doi.org/10.1166/sam.2020.3715.

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In recent years, there are increasing evidences of epidemiology and clinic which indicate that vitamin D deficiency has relationship with cardiovascular disease. It was found the levels of vitamin D were negatively correlated with cardiovascular events such as hypertension, heart failure, atrial fibrillation and coronary heart disease. This article reviews the connection between cardiovascular diseases and vitamin D, and explains the underlying mechanisms including regulating renin-angiotensin system or endothelial function, inhibition of natriuretic peptide expression or the release of parathyroid hormone, effects on inflammation or obesity, bioenergetics, activation of extracellular Ca2+, inhibition of oxidative stress, and so on. These mechanisms provide novel strategy for the treatment of these cardiovascular diseases.

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Dissertations / Theses on the topic "Cardiovascular system – Diseases – Treatment"

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Cho, Jinsoo. "Velocity-based cardiac segmentation and motion-tracking." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04082004-180106/unrestricted/cho%5Fjinsoo%5F200312%5Fphd.pdf.

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Lam, Lap-fung, and 林立峰. "Flow cytometric analysis of intra-platelet VASP for evaluation of clopidogrel resistance in ischemic heart disease patients undergoingpercutaneous coronary intervention." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48421200.

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Ischemic heart disease (IHD) is the most common cause of death around the world. The underlying cause of IHD is myocardial ischemia as a result of progressive narrowing of coronary arteries due to atherosclerosis with potential thrombotic complications mediated by platelets. In addition to the role in hemostasis, platelets are increasingly recognized as an important mediator in this atherothrombotic disease. Basic management of IHD lies on medical therapy and coronary revascularization procedures. Percutaneous coronary intervention (PCI) is a commonly used revascularization procedure in the treatment of IHD especially for relief and reduction of symptoms. On the other hand, antiplatelet therapy is often administrated to patients undergoing PCI in an attempt to prevent major adverse cardiac events (MACE) following the procedures. However not all patients respond to the same degree of the antiplatelet therapy and some still develop MACE or stent thrombosis in the presence of the treatment with antiplatelet drugs. Recently a flow cytometric-based assay has been developed to monitor the effect of the antiplatelet drug, particularly the P2Y12 receptor antagonist, in patients treated with this kind of drug. This assay measures the activity of platelets as platelet reactivity index (PRI) based on the phosphorylation state of an intracellular platelet protein called vasodilator stimulated phosphoprotein (VASP). The measured value of PRI is inversely related to the response of patient to the antiplatelet drug. In this study, the response of patients to the P2Y12 receptor antagonist Clopidogrel was investigated following PCI. The PRI of patients was found to be significantly lower than normal subjects without taking this drug, indicating the therapeutic effect of this drug on the patients. However nearly one-third of patients (17 out of 59) studied were found to be non-responsive to clopidogrel treatment based on a cut-off established in this study for classifying patients into responders or non-responders. Furthermore, significant difference between the two types of stents used in PCI procedure, namely bare metal stent (BMS) and drug eluting stent (DES), was observed in the study. Patients receiving DES had nearly three times higher percentage of being non-responsive to clopidogrel than the BMS counterpart (45% vs. 16%, p<0.028). This study provides evidence that DES may be implicated in the non-responsiveness or drug resistance of clopidogrel in patient undergoing PCI.
published_or_final_version
Pathology
Master
Master of Medical Sciences

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陳潔兒 and Kit-yee Brenda Chan. "Making it a practice: a pre-admission pre-operation education programme for patients on elective CABG." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40720111.

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Lai, Wing-hon Kevin, and 黎永漢. "Generation of vasculogenic progenitor cells from human induced pluripotent stem cells for the treatment of cardiovascular diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197112.

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Pluripotent stem cells hold great promise in regenerative medicine. Theoretically, a variety of tissues can be generated from this progeny. The production of tailor-made stem cells for individualized patient treatment is the ultimate goal of stem cell based therapy. Human induced pluripotent stem cells (iPSCs) hold the precious key to success and promote the clinical application of stem cells. By reprogramming somatic cells, pluripotent stem cells can be generated in a patient-specific manner and subsequently differentiated into specific tissue for regeneration. Nonetheless exposure of hiPSCs to animal feeder cells and serum during generation and maintenance imposes a risk of transmitting animal pathogens to human subjects, thus hindering their potential therapeutic application. In addition, the efficacy of iPSC generation is < 1% of total somatic cells used. The first part of the study focused on the development of improved methods to produce a more efficient xenogen-free culture system to produce more clinically compatible iPSCs. Specific tissue or cells derived from stem cells may offer a solution and cell therapy using endothelial cells and their progenitors may be possible in treatment of severe cardiovascular diseases. In theory, endothelial cells can be generated from different sources of progenitor cells although no direct comparison of these various derived endothelial cells (ECs) has been reported. Thus in the second part of the study, the functional and physiological properties of BM, ESC and iPSC-ECs will be evaluated to determine their therapeutic potential in ischemic disease. A mouse hind limb ischemia model was used to assess and monitor neovascularization by the derived ECs. The results can provide further insight to evaluate the possibility of using iPSCEC as the cell source for patient-specific treatment. Use of pluripotent stem cells is a promising approach in therapeutic angiogenesis although numerous hurdles continue to hamper their widespread clinical use. Conditioned medium derived from progenitor cells may be another possible strategy in the treatment of ischemic diseases such that direct cell transplantation is avoided. Conditioned media produced from ex vivo culture of endothelial cells contain a combination of angiogenic factors that can be applied to promote neovascularization in ischemic tissue. Nonetheless the efficacy of this angiogenic application is unknown. The third part of the study focused on the potential application of EC-derived conditioned media in the treatment of ischemic disease using a mouse hind limb ischemia model. Some cardiovascular risk factors such as diabetes might affect endothelial cell function such that autologous application of ECs and their conditioned media is not feasible. A human embryonic stem cell line may offer and alternative means to obtain stable quality ECs and conditioned medium for therapeutic use. In summary, advances in stem cell technology hold great promise for the treatment of cardiovascular disease, further improved by the generation of patient-specific stem cells using iPSC technology. Vascular cells can be generated from different sources of stem cells with similar angiogenic properties and may be used in the treatment of ischemic diseases.
published_or_final_version
Medicine
Doctoral
Doctor of Philosophy

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Stewart, Simon. "Optimising therapeutic efficacy in acute and chronic cardiac disease states /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phs851.pdf.

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Wang, Kai, and 王凱. "Structure-function and physiological properties of HCN-encoded pacemaker channels." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557273.

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Saikus, Christina Elena. "Towards mri-guided cardiovascular interventions." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44912.

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Imaging guidance may allow minimally invasive alternatives to open surgical exposure and help reduce procedure risk and morbidity. The inherent vascular and soft-tissue contrast of MRI make it an appealing imaging modality to guide cardiovascular interventional procedures. Advances in real-time MRI have made MRI-guided procedures a realistic possibility. The MR environment, however, introduces additional challenges to the development of compatible, conspicuous and safe devices. The overall goal of this work was to enable selected MRI-guided cardiovascular interventional procedures with clearly visible MR devices. In the first part of this work, we developed actively visualized devices for three distinct MRI-guided interventional procedures and techniques to assess their signal performance. We then investigated factors influencing complex device safety in the MR environment and evaluated a technique to better determine and monitor potential device heating. This input contributed to the development of a system to further improve device safety with continual device monitoring and dynamic scanner feedback control. In the final part of this work, we demonstrated the utility of MRI guidance and actively visualized devices to enable traditional and complex cardiovascular access. Together these provide important elements to bring MRI-guided cardiovascular interventional procedures closer to clinical implementation.

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Anchala, Raghupathy. "Management of hypertension and prevention of cardiovascular diseases in India : the role of decision support systems." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648283.

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Chiu, Sin-ming, and 趙善明. "Absence of Nucks1 enhances mesenchymal stem cells mediated cardiac protection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197087.

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Despite major advances in diagnosis and prevention of coronary artery disease (CAD), the development of therapies to regenerate functional cardiomyocytes after myocardial infarction (MI) is very challenging. Studies have demonstrated that bone marrow derived mesenchymal stem cells (BM-MSCs) secrete a panel of growth factors and anti-inflammatory cytokines to activate resident cardiomyocytes and cardiac stem cells in myocardial repair after MI. However, the mechanisms of modulating BM-MSC secretions are not well understood. Recently, molecular candidates in regulating BM-MSCs paracrine secretion to improve cardiac protection have been explored. Amongst the molecular candidates, Nuclear casein kinase and cyclin-dependent kinase substrate 1 (Nucks1) is suggested as a regulatory protein in nuclear factor-kappa B (NF-κB) signaling pathway by interacting with TANK-binding kinase 1 (TBK1). TBK1 is a non-canonical I kappa B (IκB) kinase that can activate the NF-κB transcription factor and its transcriptional response. NF-κB signaling pathway controls many cellular responses such as cell survival, proliferation and cytokine productions. We hypothesizes Nucks1 may have potential roles in regulating mouse BM-MSCs secretion of growth factors and cytokine profiles in heart repairs after MI. To test our hypothesis, the cardiac protection efficacy of acute infarcted mouse myocardium was measured after the transplantation of WT versus Nucks1 KO BM-MSCs. To this end, we developed a mouse model of acute myocardial infarction (AMI) induced by ligation of left descendant coronary artery. Acute infarcted mouse myocardium receiving WT or Nuck1 KO BM-MSCs transplantation, demonstrated a significant improvement of left ventricular ejection fraction (LVEF), ESP, +dP/dt, ESPVR and vessel density, and reduced infarction size in comparison with PBS control group post-4 weeks of transplantation. Furthermore, acute infarcted mouse myocardium receiving Nucks1 KO BM-MSCs transplantation provided better cardioprotective effects than those receiving WT BM-MSCs transplantation. Immunostaining disclosed CD31 and smooth muscle actin (SMA) expression in acute infarcted mouse myocardium receiving Nucks1 KO BM-MSCs were relatively higher than those receiving WT BM-MSCs transplantation. Additionally, a distinct secretion profile of growth factors and cytokines between Nucks1 KO BM-MSCs versus WT BM-MSCs under in vitro ischemia was studied. Expression of vascular endothelial growth factor alpha (VEGFα) in Nucks1 KO BM-MSCs under hypoxia/ serum deprivation was significantly higher than that of WT BMMSCs. Taken together, our data suggested BM-MSCs provide cardiac protection in acute infarcted myocardium. Transplantation of Nucks1 KO BMMSCs may further enhance the cardiac repair of the acute infracted myocardium through an induction of VEGFα.
published_or_final_version
Medicine
Master
Master of Philosophy

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Chan, Hoi Huen. "The vascular modulation effect of Panax ginseng." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1518.

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Books on the topic "Cardiovascular system – Diseases – Treatment"

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S, Dhalla Naranjan, ed. Pathophysiology of cardiovascular diseases. Boston: Kluwer Academic Publishers, 2004.

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Grines, Cindy, and Mark Freed. Essentials of cardiovascular therapy, 1994. Birmingham, Mich: Physicians' Press, 1994.

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Jenkins, Jimmy S. Victory over disease: Long term treatment of cardiovascular disease. Goodlettsville, Tenn: Cardiovascular Pharmacy Consultants, Inc., 1988.

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Nanomedicine and the cardiovascular system. Boca Raton, FL: CRC Press, 2011.

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David, Hoffmann. Healthy heart: Strengthen your cardiovascular system. Pownal, Vt: Storey Books, 2000.

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Haberman, Allan B. New strategies in cardiovascular therapeutics. Waltham, MA: Decision Resources, 1997.

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Cutler, David M. Intensive medical care and cardiovascular disease disability reductions. Cambridge, Mass: National Bureau of Economic Research, 2006.

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Jain, Kewal K. Applications of biotechnology in cardiovascular therapeutics. New York: Humana Press, 2011.

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Group, New Zealand Guidelines. New Zealand cardiovascular guidelines handbook: A summary resource for primary care practitioners. 2nd ed. Wellington, N.Z: New Zealand Guidelines Group, 2009.

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Chatterjee, Kanu, and Phillip A. Horwitz. Advances in cardiology. New Delhi: Jaypee Brothers Medical Publishers, 2014.

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Book chapters on the topic "Cardiovascular system – Diseases – Treatment"

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Frohlich, Edward D., and Javier Díez. "Left Ventricular Hypertrophy and Treatment with Renin Angiotensin System Inhibition." In Renin Angiotensin System and Cardiovascular Disease, 103–19. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-186-8_9.

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Daugschies, Arwid, and Jozef Vercruysse. "Cardiovascular System Diseases, Animals." In Encyclopedia of Parasitology, 1–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_515-2.

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Daugschies, Arwid, and Jozef Vercruysse. "Cardiovascular System Diseases, Animals." In Encyclopedia of Parasitology, 410–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_515.

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Palermo, A., and A. Libretti. "Ketanserin in the treatment of hypertension: clinical review." In Atherosclerosis and Cardiovascular Diseases, 361–66. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3205-0_47.

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Abutarbush, Sameeh M. "Diseases of the Cardiovascular System." In Illustrated Guide to Equine Diseases, 119–73. Ames, Iowa, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119265399.ch2.

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Wagner, Robert A. "Diseases of the Cardiovascular System." In Biology and Diseases of the Ferret, 401–19. Ames, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118782699.ch18.

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Eliseev, Oleg M. "Examination of the Cardiovascular System in Pregnancy." In Cardiovascular Diseases and Pregnancy, 16–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73605-6_3.

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Song, Yao-Hua, Lianbo Shao, Yu Zhang, Jin Zhou, Bin Liu, Xiangbin Pan, Yong-jian Geng, Xi-yong Yu, and Yangxin Li. "Exosomes Derived from Embryonic Stem Cells as Potential Treatment for Cardiovascular Diseases." In Exosomes in Cardiovascular Diseases, 187–206. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4397-0_13.

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Pagano, G., G. Niort, P. Nuccio, and A. Bulgarelli. "Role of fibrinogen in atherosclerosis: therapeutic effects of bezafibrate in short-term treatment." In Atherosclerosis and Cardiovascular Diseases, 431–37. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3205-0_57.

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Moritz, Mark W., Michael Ombrellino, and Harry Agis. "Laser Treatment of the Venous System." In Lasers in Cardiovascular Interventions, 321–36. London: Springer London, 2015. http://dx.doi.org/10.1007/978-1-4471-5220-0_24.

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Conference papers on the topic "Cardiovascular system – Diseases – Treatment"

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Chtchoupak, Oleg S., Boris N. Shpilevoj, and Natlia L. Zapaeva. "Laser-based optoelectronic system for therapy by medical treatment of cardiovascular diseases." In BiOS Europe '95, edited by Stefan Andersson-Engels, Mario Corti, Ivan Kertesz, Norbert Kroo, Heinz P. Weber, Terence A. King, Riccardo Pratesi, and Stefan Seeger. SPIE, 1996. http://dx.doi.org/10.1117/12.229526.

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Chtchoupak, Oleg S., Boris N. Spilevoi, and Natlia L. Zapaeva. "Laser-based optoelectronic system for therapy by medical treatment of cardiovascular diseases." In Photonics West '96, edited by Kurt J. Linden and Prasad R. Akkapeddi. SPIE, 1996. http://dx.doi.org/10.1117/12.237643.

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Narasimhan, Lakshmi, Di Wu, and Narinder Gill. "Meta-Analysis of Clinical Cardiovascular Data towards Evidential Reasoning for Cardiovascular Life Cycle Management." In InSITE 2007: Informing Science + IT Education Conference. Informing Science Institute, 2007. http://dx.doi.org/10.28945/3147.

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The cardiovascular disease is one of the serious and life-threatening diseases in the developed world. One aspect of medical treatment is using drugs with blood pressure reducing or cholesterol lowering functions. Importantly, such treatment needs to be individually tailored and is significantly correlated to the particular conditions of individual patients. However, such pathologies and mechanisms are still only under investigation. Several novel and unique computational methods, called meta-analyses techniques, for formatting and analyzing a wide variety of cardiac datasets are discussed in this paper with the aim to building cardiovascular database and related patient life-cycle management services. In this paper we also present an overview of a second order inference engine underlying the meta-analyses, which yields evidenced-based reasoning that is more likely to better assist decision-making on the effectiveness of cardiovascular treatment than what is available currently. Furthermore, the software architecture and other details of such a medical informatics system tailored to cardiovascular disease are also described. Research and development work on this project yields itself to application to many other areas, such as disease control and prevention in Epidemiology, and dietics. The system can therefore make a profound impact to medical informatics.

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Al-Ansari, Dana E., Nura A. Mohamed, Isra Marei, Huseyin Yalcin, and Haissam Abou-Saleh. "Assessment of Metal Organic Framework as Potential Drug Carriers in Cardiovascular Diseases." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0127.

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Background: Cardiovascular diseases (CVDs) are considered the major cause of death worldwide. Therapeutic delivery to the cardiovascular system may play an important role in the successful treatment of a variety of CVDs, including atherosclerosis, ischemic-reperfusion injury, and microvascular diseases. Despite their clinical benefits, current therapeutic drugs are hindered by their short half-life and systemic side effects. This limitation could be overcome using controlled drug release with the potential for targeted drug delivery using a nanomedicine approach. In the current study, we have assessed the use of a highly porous nano-sized preparation of iron-based Metal-organic Framework (MOF) commonly referred to as MIL-89 as potential drug carriers in the cardiovascular system. Aims: To assess the effect of MOFs on the viability and cytotoxicity of human vascular cells and the cellular uptake in vitro, and the organ-system toxicity of MOF in vivo using the Zebrafish model. Methods: Human pulmonary endothelial cells (HPAECs) and pulmonary smooth muscle cells (HPASMCs) were treated with variable concentrations of MOFs. The viability, cytotoxicity and anti-inflammatory effects were measured using AlamarBlue, LDH assay and ELISA. The cellular uptake of MOFs were assessed using light, confocal, and transmission electron microscopes and EDS analysis. Moreover, Zebrafish embryos were cultured and treated with MOFs-nanoparticles at 0 hours post fertilization (hpf) followed by different organ-specific assays at 24, 48, and 72 hpf. Results: Although MOFs affect the viability at high concentrations, it does not cause any significant cytotoxicity on HPAECs and HPASMCs. Interestingly, MOFs were shown to have an anti-inflammatory effect. Microscopic images showed an increased (concentration-dependent) cellular uptake of MOFs and transfer to daughter cells in both cell types. Moreover, the in vivo study showed that high concentrations of MOFs delay zebrafish embryos hatching and cause heart deformation, which is currently investigated using cardiotoxicity markers. Conclusion: MOFs is a promising nanoparticle prototypes for drug delivery in the cardiovascular system with high cellular uptake and anti-inflammatory effects. Further investigations of MOFs, including diseased models and drug- loaded formulation is required.

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Киреева, Виктория, Viktoriya Kireeva, Г. Лифшиц, G. Lifshic, Н. Кох, N. Koh, Ю. Усольцев, Yu Usolcev, Константин Апарцин, and Konstantin Apartsin. "Advantages of a personalized approach to the prevention and treatment of cardiovascular diseases in the staff of the INC Of the SBRAS." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. Москва: INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec9ed47.

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Purpose of the study. To test the functional associations of polymorphic variants of genes in the regulation of blood pressure and vascular tone in employees of the ISC SB RAS. Materials and methods. The study involved patients, employees of the ISC SB RAS, being under care of the outpatient clinic of the Hospital of the ISC SB RAS. During routine laboratory testing the patients were taken 2 ml of blood for genetic analysis and further molecular genetic study on “Hypertension”, “Endothelial dysfunction”, “Pharmacogenetics”, “Inflammatory response” panels. Results. In the analysis of 12 genes coding for key proteins of hormonal enzyme blood pressure regulation systems, polymorphism of CYP11B2 showed statistically significant correlation with the presence of arterial hypertension, which makes its further study promising. The presence of allele C showed protective significance in relation to the development of hypertension with OR = 0,247. When checking associations of functional polymorphic variants of genes, the products of which are involved in the regulation of vascular tone, with hypertension in patients younger than 50 years old we found association of T/T rs5443GNB3 genotype with the debut of hypertensive disease under the age of 50. The data obtained allow the doctor to choose the most personalized and effective safe drug from certain groups, as well as its dose for employees having passed molecular genetic testing. These data can reveal predisposition to the most widespread and socially significant diseases in the surveyed subjects and provide specific personalized recommendations for the prevention of these diseases.

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Richardson, William J., Dennis D. van der Voort, and James E. Moore. "A Device to Subject Cells to Longitudinal Stretch Gradients on a Tube In Vitro." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80941.

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In the US, cardiovascular disease accounts for more than 800,000 deaths and an economic burden of nearly $300 billion per year. A major pathology afflicting the cardiovascular system is atherosclerosis, characterized by intraluminal plaque formation, producing a stenosis and obstructing flow. Balloon angioplasty, often coupled with the implantation of either a bare-metal or drug-eluting stent, has become a standard treatment of atherosclerosis. However, the host tissue’s response to stenting is frequently maladaptive, leading to intimal hyperplasia via smooth muscle cell (SMC) division and migration to the intima, and increased matrix protein synthesis, all contributing to restenosis of the vessel.

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Dahmen, Christian, Tim Wortmann, and Sergej Fatikow. "Magnetic Resonance Imaging of Magnetic Particles for Targeted Drug Delivery." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13149.

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Recently there have been initial investigations towards magnetic resonance imaging (MRI) guided actuation and control of untethered devices inside the human cardiovascular system. This form of therapy has the potential to revolutionize today’s treatment of cancer and other diseases by providing an accuracy of targeted drug application far beyond conventional approaches. Additionally it is based on standard MRI hardware and does not require any special or tailored hardware. In this article, we present recent work that is focused on visual feedback for the position control of untethered magnetic devices in the MRI. For reliable recognition and tracking, a thorough understanding of the impact of magnetic material on the process of MRI image acquisition is required. A simulation of the image formation process has been implemented. Additionally, initial experimental results of MRI artifact imaging are presented.

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Valenti, Isabella E., Breigh N. Roszelle, Michael V. Perone, Steven Deutsch, and Keefe B. Manning. "Impact of Outlet Valve Orientation on Fluid Dynamics of the 12 cc Penn State Pediatric Ventricular Assist Device." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192744.

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Congenital cardiovascular defects are the leading cause of death among live births [1]. These defects involve the interior walls of the heart, valves, arteries, and veins and change the normal flow of blood through the heart and into the systemic system. Fortunately, several options exist for the more than 35,000 children born with congenital heart disease. Ventricular assist devices (VADs) currently hold the most promise for bridge-to-transplant treatment; however, a major problem for these devices is thrombus formation and deposition.

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Rasponi, Marco, Francesco Piraino, Nicola Cagol, Matteo Moretti, Gianfranco B. Fiore, and Alberto Redaelli. "Development of a Microfluidic Device Embedding High-Conductivity Flexible Electrodes for Three-Dimensional Cell Culture Stimulations." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80658.

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Successful treatment of cardiovascular diseases has so far been limited by the lack of suitable autologous tissue to restore injured tissues. Currently, a novel encouraging frontier for such treatment is represented by tissue engineering [1]. Although traditional bioreactors for cardiac tissue engineering, based on a classical macro-scale approach, are widely used, research for identifying effective stimulation patterns has not lead to robust results yet. In this sense, the phenomena driving cell growth and differentiation become more addressable in reduced-scale systems, and microfluidics represents a valid alternative approach to overcome traditional bioreactors limitations. In order to favor the differentiation paths, recently developed microfluidic bioreactors tend to increase the control within cell culture chambers by coupling mechanical, electrical, thermical or optical effects. In particular, stem cell differentiation into cardiomyocytes seems to draw beneficial effects from electrical and mechanical stimulations [2]. This work introduces a simple method of embedding conductive and flexible material within microfluidic devices as a means to realize microscale bioreactors for cell electro-mechanical stimulation. Thanks to the proposed technology, high conductivity three-dimensional (3D) electrodes can be simply realized.

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Du, Wei, Kenneth M. Pryse, Judy A. Fee, Elliot L. Elson, and Ruth J. Okamoto. "Vascular Smooth Muscle Cell Mechanics During Cyclic Stretch: Effect of Serum and a Serum Substitute." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176205.

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Remodeling of arteries in response to altered loads is an area of intense interest to cardio-vascular clinicians and researchers. In humans, changes due to cardiovascular diseases (e.g. aortic dilatation) may occur slowly over many years, and mathematical models that describe the remodeling response are needed for predicting the course, and possible treatment, of these diseases. Recently, Humphrey and co-workers have proposed constrained mixture models [1] that consider local stresses in the arterial wall to be the sum of contributions from collagen, elastic fibers, and vascular smooth muscle cells (VSMCs). While numerous studies (e.g., [2]) have considered the active response of VSMCs in large arteries under quasi-static conditions, little is known about the mechanical response of VSMCs to continuous cyclic stretch. We have chosen 3-D bio-artificial tissue constructs as a model system in which to study the response of VSMCs to continuous cyclic stretch. However, VSMCs undergo a shift from a contractile phenotype to a de-differentiated phenotype during culture [3]. Some investigators have suggested that serum deprivation can induce re-differentiation toward a more contractile phenotype [4, 5]. The goal of our study was to compare the effect of incubation conditions on the active responses of VSMCs in 3-D tissue constructs to continuous cyclic stretch.

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Reports on the topic "Cardiovascular system – Diseases – Treatment"

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Yu, Miao, Hong Yu, and Jianrong Li. Effectiveness of traditional Chinese medicine enema in the recovery of gastrointestinal function in the abdominal surgical treatment of digestive system diseases: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0039.

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