Relevant bibliographies by topics / Cardiovascular system – Diseases – Genetic aspects

Academic literature on the topic 'Cardiovascular system – Diseases – Genetic aspects'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Cardiovascular system – Diseases – Genetic aspects.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Cardiovascular system – Diseases – Genetic aspects"

1

Tatour, Yasmin, and Tamar Ben-Yosef. "Syndromic Inherited Retinal Diseases: Genetic, Clinical and Diagnostic Aspects." Diagnostics 10, no. 10 (October 2, 2020): 779. http://dx.doi.org/10.3390/diagnostics10100779.

Full text
Abstract:
Inherited retinal diseases (IRDs), which are among the most common genetic diseases in humans, define a clinically and genetically heterogeneous group of disorders. Over 80 forms of syndromic IRDs have been described. Approximately 200 genes are associated with these syndromes. The majority of syndromic IRDs are recessively inherited and rare. Many, although not all, syndromic IRDs can be classified into one of two major disease groups: inborn errors of metabolism and ciliopathies. Besides the retina, the systems and organs most commonly involved in syndromic IRDs are the central nervous system, ophthalmic extra-retinal tissues, ear, skeleton, kidney and the cardiovascular system. Due to the high degree of phenotypic variability and phenotypic overlap found in syndromic IRDs, correct diagnosis based on phenotypic features alone may be challenging and sometimes misleading. Therefore, genetic testing has become the benchmark for the diagnosis and management of patients with these conditions, as it complements the clinical findings and facilitates an accurate clinical diagnosis and treatment.
APA, Harvard, Vancouver, ISO, and other styles
2

Kireeva, Victoria Vladimirovna, Svetlana Aleksandrovna Lepekhova, Lyubov Nazirovna Mansurova, and Saryuna Chingisovna Dugarova. "EPIGENETIC AND MOLECULAR AND GENETIC ASPECTS OF OBESITY AS A RISK FACTOR OF CARDIOVASCULAR CATASTROPHES." EurasianUnionScientists 5, no. 7(76) (August 20, 2020): 39–44. http://dx.doi.org/10.31618/esu.2413-9335.2020.5.76.926.

Full text
Abstract:
The review provides current information of obesity in the pathogenesis of cardiovascular diseases the leading cause of death. Showing the genetic basis for the development of metabolic syndrome. The question of external influence on genes, mutations in which lead to the development of obesity is determined. The question of the possible role of exogenous destroyers in the development of metabolic syndrome is considered. The main genes involved in monogenic and polygenic variants of obesity are identified. The review shows that to prevent the development of metabolic syndrome, it is necessary to form risk groups and to take mandatory preventive activity in these groups. Pathogenetic significance determines the attention of clinicians to this pathology, and the molecular and genetic aspects of formation the cardiovascular diseases dictate the need for personalized medicine to predict and prevent, and pharmacogenetics to correct obesity, metabolic syndrome and the cardiovascular system as a whole.
APA, Harvard, Vancouver, ISO, and other styles
3

Sychev, Dmitry A., Igor N. Sychev, Karin B. Mirzaev, Eric I. Rytkin, Dmitriy V. Ivashchenko, Irina V. Bure, and Vitaliy A. Otdelenov. "Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants." Annals of the Russian academy of medical sciences 74, no. 5 (December 4, 2019): 299–306. http://dx.doi.org/10.15690/vramn1214.

Full text
Abstract:
One of the main causes for adverse reactions development is not taking into account the pharmacokinetics of drugs and the dose. Pharmacokinetics of drugs is mostly defined by the cytochrome P-450 isoenzymes activity, carboxylesterases and many other isoenzymes of drug metabolism, as well as ADME transporters (P-gp etc.) which take part in the process of drug metabolism. The activity of these isoenzymes is defined by the genetic aspects of patients and non-genetic aspects such as comorbidity and drug-drug interactions. The development of complex algorithms for personalization of therapy based on the results of pharmacogenetic studies and in the form of a decision support system will play an important role in reduction of adverse drug reactions. A lot can be achieved for personalization of Direct Oral Anticoagulants for treatment of cardiovascular diseases. New approaches are being developed based on the results of pharmacogenetic and pharmacokinetic testing that will help diminish adverse effects of drugs.
APA, Harvard, Vancouver, ISO, and other styles
4

Jones, Elizabeth A. V., Ferdinand le Noble, and Anne Eichmann. "What Determines Blood Vessel Structure? Genetic Prespecification vs. Hemodynamics." Physiology 21, no. 6 (December 2006): 388–95. http://dx.doi.org/10.1152/physiol.00020.2006.

Full text
Abstract:
Vascular network remodeling, angiogenesis, and arteriogenesis play an important role in the pathophysiology of ischemic cardiovascular diseases and cancer. Based on recent studies of vascular network development in the embryo, several novel aspects to angiogenesis have been identified as crucial to generate a functional vascular network. These aspects include specification of arterial and venous identity in vessels and network patterning. In early embryogenesis, vessel identity and positioning are genetically hardwired and involve neural guidance genes expressed in the vascular system. We demonstrated that, during later stages of embryogenesis, blood flow plays a crucial role in regulating vessel identity and network remodeling. The flow-evoked remodeling process is dynamic and involves a high degree of vessel plasticity. The open question in the field is how genetically predetermined processes in vessel identity and patterning balance with the contribution of blood flow in shaping a functional vascular architecture. Although blood flow is essential, it remains unclear to what extent flow is able to act on the developing cardiovascular system. There is significant evidence that mechanical forces created by flowing blood are biologically active within the embryo and that the level of mechanical forces and the type of flow patterns present in the embryo are able to affect gene expression. Here, we highlight the pivotal role for blood flow and physical forces in shaping the cardiovascular system.
APA, Harvard, Vancouver, ISO, and other styles
5

Saveleva, N. N., I. I. Sokolova, S. I. German, and T. V. Tomilina. "SOME ASPECTS OF THE EATIOLOGY OF PARODONTUS DISEASES. (LITERATURE REVIEW)." Ukrainian Dental Almanac, no. 2 (June 25, 2018): 54–59. http://dx.doi.org/10.31718/2409-0255.2.2018.13.

Full text
Abstract:
The review of the scientific literature is devoted to the topical issues of studying the etiology of periodontal diseases, which are one of the most common and complex pathologies of the maxillofacial region. Analysis of recent studies proves a stable relationship between the development of periodontal diseases and disorders in the immune system, the neurohumoral system, metabolic disorders, genetic predisposition, and so on. The article presents the data obtained in the course of studying the literature on the role of disorders in the functioning of individual organs (gastrointestinal tract, liver, lungs, heart, and urinary system) in the development of chronic periodontal diseases. The article notes that the anatomical and physiological proximity of the periodontal and digestive tract tissues, the generality of innervation and humoral regulation create prerequisites for the involvement of periodontal disease in the pathological process in diseases of the gastrointestinal tract. One of the main etiological factors in the development of inflammatory diseases of the gastrointestinal tract and periodontium is Helicobacter pylori, which is found in the loci of the oral cavity: in the oral and gingival fluid, on the mucous membrane of the tongue and cheeks, and in the periodontal pockets. It is pointed out that the liver also occupies a special place in the development of periodontal diseases, which is explained by the performance of its significant functions for the human body: regulatory, metabolic, antitoxic and other. There is evidence that the pathology of periodontal disease plays a leading role in the structure of dental diseases in patients with chronic obstructive pulmonary diseases, which is clinically manifested by symptoms of generalized periodontitis of the І-ІІ degrees of development and its complications - partial or complete secondary adentia, and with tooth preservation - defects in dental series and violations of occlusion, function, aesthetics. Scientists suggest a general biological mechanism for the development of generalized periodontitis and cardiovascular diseases, linking the development of periodontal diseases in patients with cardiovascular pathology with microcirculatory disorders. The dependence of the severity of inflammatory changes in the periodontal tissues on the disturbances of salt metabolism in urolithiasis is proved. The data obtained indicate that diseases of the internal organs contribute to the structural damage of periodontal tissues and they are a risk factor for periodontal diseases, which necessitate the presence of not only theoretical knowledge and practical skills in dentistry, but also their awareness of the features and clinical manifestations of somatic pathology. An urgent and justified step in the treatment of periodontal diseases is also the involvement in the process of rendering complex dental care to internist doctors capable of quickly and qualitatively assessment the condition of the internal organs and the basic systems of the patient's body.
APA, Harvard, Vancouver, ISO, and other styles
6

Fajemiroye, James Oluwagbamigbe, Luiz Carlos da Cunha, Roberto Saavedra-Rodríguez, Karla Lima Rodrigues, Lara Marques Naves, Aline Andrade Mourão, Elaine Fernanda da Silva, et al. "Aging-Induced Biological Changes and Cardiovascular Diseases." BioMed Research International 2018 (June 10, 2018): 1–14. http://dx.doi.org/10.1155/2018/7156435.

Full text
Abstract:
Aging is characterized by functional decline in homeostatic regulation and vital cellular events. This process can be linked with the development of cardiovascular diseases (CVDs). In this review, we discussed aging-induced biological alterations that are associated with CVDs through the following aspects: (i) structural, biochemical, and functional modifications; (ii) autonomic nervous system (ANS) dysregulation; (iii) epigenetic alterations; and (iv) atherosclerosis and stroke development. Aging-mediated structural and biochemical modifications coupled with gradual loss of ANS regulation, vascular stiffening, and deposition of collagen and calcium often disrupt cardiovascular system homeostasis. The structural and biochemical adjustments have been consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels. In addition, cardiomyocyte loss in this process often reduces adaptive capacity and cardiovascular function. The accumulation of epigenetic changes also plays important roles in the development of CVDs. In summary, the understanding of the aging-mediated changes remains promising towards effective diagnosis, discovery of new drug targets, and development of new therapies for the treatment of CVDs.
APA, Harvard, Vancouver, ISO, and other styles
7

Macit, Melahat S., and Nilüfer Acar-Tek. "Current Perspectives for Diabetes and Allostatic Load: The Role of Nutrition." Current Nutrition & Food Science 15, no. 7 (November 12, 2019): 646–52. http://dx.doi.org/10.2174/1573401314666180620164859.

Full text
Abstract:
Allostasis and allostatic load are new concepts explaining the changes in body stemming from chronic stress. These concepts are explained with the assessment of metabolic, cardiovascular, inflammatory, and neuroendocrine systems. Type 2 Diabetes Mellitus (DM) is a chronic disease with the fluctuations in fasting plasma glucose, and also in other various biomarkers and poses a risk forother chronic diseases. The course and duration of the disease, genetic factors, and environmental factors, including nutrition, aggravate these complications. Allostatic load is a multi-system assessment. Individuals’ compliance with the medical nutrition therapy in the short and long-term, changes in anthropometric and biochemical biomarkers that are used to measure the nutritional status. In the monitoring of patients with diabetes, it’s important to assess metabolic, cardiovascular, neuroendocrine, and immune system biomarkers as well as fasting blood glucose. There exist studies in the literature, investigating the relationship of the allostatic load with socio-economic status, chronic diseases such as diabetes and cardiovascular diseases, gender, and ethnicity. In these studies, chronic stress, nutritional status, stress, and allostasis are briefly described. In the present literature review, it was aimed to evaluate different aspects of the relationships among diabetes, nutrition, allostatic load, and stress.
APA, Harvard, Vancouver, ISO, and other styles
8

Demidov, O. N., A. V. Shakula, G. V. Gulevatiy, and A. V. Sobolev. "Role of clonal gemopoeisis in development of individual approaches for early diagnostics, treatment and rehabilitation of patients with cardio-vascular diseases." Bulletin of Restorative Medicine 97, no. 3 (June 28, 2020): 45–49. http://dx.doi.org/10.38025/2078-1962-2020-97-3-45-49.

Full text
Abstract:
Recently, due to significant improvement and cheapening of the new generation of full genome sequencing technology, it has become possible to identify acquired mutations in individual cells of the hematopoietic system. This has led to the detection of clones of hematopoietic cells with acquired mutations in certain genes in middle-aged and elderly people and made it possible to characterize a new prepathological state - clonal hemopoiesis. Clonal hemopoiesis is defined as the appearance and clonal expansion of cells of the hemopoietic system with genetic changes that give these cells certain advantages in proliferation and/or resistance to adverse factors in comparison with other hemopoietic cells. This phenomenon is found mainly in individuals after 55 years of age and is practically not found in individuals of young age. At this age, most individuals show signs of cardiovascular pathology of some degree of severity. This review discusses some aspects of the possible impact of clonal hemopoiesis on cardiovascular diseases.
APA, Harvard, Vancouver, ISO, and other styles
9

Motta, Benedetta M., Peter P. Pramstaller, Andrew A. Hicks, and Alessandra Rossini. "The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches." Stem Cells International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/8960236.

Full text
Abstract:
Genome-editing technology has emerged as a powerful method that enables the generation of genetically modified cells and organisms necessary to elucidate gene function and mechanisms of human diseases. The clustered regularly interspaced short palindromic repeats- (CRISPR-) associated 9 (Cas9) system has rapidly become one of the most popular approaches for genome editing in basic biomedical research over recent years because of its simplicity and adaptability. CRISPR/Cas9 genome editing has been used to correct DNA mutations ranging from a single base pair to large deletions in both in vitro and in vivo model systems. CRISPR/Cas9 has been used to increase the understanding of many aspects of cardiovascular disorders, including lipid metabolism, electrophysiology and genetic inheritance. The CRISPR/Cas9 technology has been proven to be effective in creating gene knockout (KO) or knockin in human cells and is particularly useful for editing induced pluripotent stem cells (iPSCs). Despite these progresses, some biological, technical, and ethical issues are limiting the therapeutic potential of genome editing in cardiovascular diseases. This review will focus on various applications of CRISPR/Cas9 genome editing in the cardiovascular field, for both disease research and the prospect of in vivo genome-editing therapies in the future.
APA, Harvard, Vancouver, ISO, and other styles
10

Cai, Wanwan, Wanbang Zhou, Zhe Han, Junrong Lei, Jian Zhuang, Ping Zhu, Xiushan Wu, and Wuzhou Yuan. "Master regulator genes and their impact on major diseases." PeerJ 8 (October 6, 2020): e9952. http://dx.doi.org/10.7717/peerj.9952.

Full text
Abstract:
Master regulator genes (MRGs) have become a hot topic in recent decades. They not only affect the development of tissue and organ systems but also play a role in other signal pathways by regulating additional MRGs. Because a MRG can regulate the concurrent expression of several genes, its mutation often leads to major diseases. Moreover, the occurrence of many tumors and cardiovascular and nervous system diseases are closely related to MRG changes. With the development in omics technology, an increasing amount of investigations will be directed toward MRGs because their regulation involves all aspects of an organism’s development. This review focuses on the definition and classification of MRGs as well as their influence on disease regulation.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Cardiovascular system – Diseases – Genetic aspects"

1

McCaskie, Pamela Ann. "Multiple-imputation approaches to haplotypic analysis of population-based data with applications to cardiovascular disease." University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0160.

Full text
Abstract:
[Truncated abstract] This thesis investigates novel methods for the genetic association analysis of haplotype data in samples of unrelated individuals, and applies these methods to the analysis of coronary heart disease and related phenotypes. Determining the inheritance pattern of genetic variants in studies of unrelated individuals can be problematic because family members of the studied individuals are often not available. For the analysis of individual genetic loci, no problem arises because the unit of interest is the observed genotype. When the unit of interest is the linear combination of alleles along one chromosome, inherited together in a haplotype, it is not always possible to determine with certainty the inheritance pattern, and therefore statistical methods to infer these patterns must be adopted. Due to genotypic heterozygosity, mutliple possible haplotype configurations can often resolve an individual's genotype measures at multiple loci. When haplotypes are not known, but are inferred statistically, an element of uncertainty is thus inherent which, if not dealt with appropriately, can result in unreliable estimates of effect sizes in an association setting. The core aim of the research described in this thesis was to develop and implement a general method for haplotype-based association analysis using multiple imputation to appropriately deal with uncertainty haplotype assignment. Regression-based approaches to association analysis provide flexible methods to investigate the influence of a covariate on a response variable, adjusting for the effects of other variables including interaction terms. ... These methods are then applied to models accommodating binary, quantitative, longitudinal and survival data. The performance of the multiple imputation method implemented was assessed using simulated data under a range of haplotypic effect sizes and genetic inheritance patterns. The multiple imputation approach performed better, on average, than ignoring haplotypic uncertainty, and provided estimates that in most cases were similar to those observed when haplotypes were known. The haplotype association methods developed in this thesis were used to investigate the genetic epidemiology of cardiovascular disease, utilising data for the cholesteryl ester transfer protein gene (CETP), the hepatic lipase (LIPC) gene and the 15- lipoxygenase (ALOX15) gene on a total of 6,487 individuals from three Western Australian studies. Results of these analyses suggested single nucleotide polymorphisms (SNPs) and haplotypes in the CETP gene were associated with increased plasma high-density lipoprotein cholesterol (HDL-C). SNPs in the LIPC gene were also associated with increased HDL-C and haplotypes in the ALOX15 gene were associated with risk of carotid plaque among individuals with premature CHD. The research presented in this thesis is both novel and important as it provides methods for the analysis of haplotypic associations with a range of response types, while incorporating information about haplotype uncertainty inherent in populationbased studies. These methods are shown to perform well for a range of simulated and real data situations, and have been written into a statistical analysis package that has been freely released to the research community.
APA, Harvard, Vancouver, ISO, and other styles
2

Wilder, Steven P. "Computational analysis of susceptibility genes for diabetes and cardiovascular diseases in animal models." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670109.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Thomas, Saralene Iona. "Genetic markers in the differential diagnosis in a family setting of episodic loss of consciousness." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51777.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Pretorius, Jakobus. "Investigation of the relationship between genetic and environmental risk factors associated with obesity and insulin resistance in South African patients with non-alcoholic fatty liver disease(NAFLD)." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71689.

Full text
Abstract:
Thesis (MSCMedSc)--Stellenbosch University, 2012.
Includes bibliography
ENGLISH ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The disease spectrum of NAFLD extends from steatosis (types 1,2) to non-alcoholic steatohepatitis (NASH) with inflammation (types 3,4). The aims of the study were 1) to analytically validate high-throughput real time polymerase chain reaction (RT-PCR) assays for three selected single nucleotide polymorphisms (SNPs), FTO rs9939609 (intron 1 T>A), TNF-α rs1800629 (-308 G>A) and PPARγ rs1801282 (Pro12Ala, 34 C>G), and 2) to perform genotype-phenotype association studies in relation to biochemical abnormalities, disease severity and age of onset. A total of 119 patients with fatty liver identified on ultrasound, including 88 histologically confirmed NAFLD patients, and 166 control individuals were genotyped for the three selected SNPs. RT-PCR validated against direct sequencing as the gold standard was used for detection of genetic variation. All three SNPs were in Hardy Weinberg equilibrium in the study population, except for a deviation in genotype distribution detected for PPARγ rs1801282 in the NAFLD patient subgroup (p<0.001). After adjustment for age and gender, the risk-associated FTO rs9939609 A-allele was detected at a significantly higher frequency in the Caucasian compared with Coloured patients (p=0.005). The opposite was detected for the risk-associated TNF-α rs1800629 A-allele, which occurred at a significantly higher frequency in the Coloured compared with Caucasian NAFLD patients (p=0.034). The onset of fatty liver disease symptoms was on average 5 years younger in the presence of each risk-associated TNF-α rs1800629 A-allele (p=0.028). When considered in the context of an inferred genotype risk score ranging from 0-6, disease onset occurred on average 3 years earlier (p=0.008) in the presence of each risk-associated FTO A-allele, TNF-α A-allele or PPARγ C-allele. After adjustment for age, gender and race, no differences in genotype distribution or allele frequencies were observed between histologically confirmed NAFLD (types 1,2) and NASH (types 3,4) patients, while the minor allele frequency for the TNF-α rs1800629 was significantly higher in the total NAFLD (types 1-4) (p=0.047) as well as NASH subgroup (NAFLD types 3,4) (p=0.030) compared with obese patients without a histologically confirmed NAFLD diagnosis. A significant correlation was furthermore observed between the number of TNF-α rs1800629 A-alleles and increasing CRP levels (p=0.029), with a favourable reduced effect in the presence of low- to moderate alcohol intake. The average waist circumference of physically active NAFLD patients was 12% lower than in physically inactive patients (p=0.004). In view of the results presented in this study, the inclusion of the selected SNPs, and in particular the pro-inflammatory TNF-α rs1800629 polymorphism, may be considered as part of a comprehensive cardiovascular risk evaluation of NAFLD patients. Ultimately, early detection of patients with fatty liver disease symptoms and effective intervention based on the underlying disease mechanism may prevent progression from NAFLD to NASH, shown to be an independent risk factor for cardiovascular diseases.
AFRIKAANSE OPSOMMING: Nie-alkoholiese lewervervetting (NALV) is die mees algemene kroniese lewersiekte in die wêreld. Die siektespektrum van NALV strek van steatose (vervette lewer tipes 1,2) tot steatohepatitis met inflammasie (NASH tipes 3,4). Die doel van die studie was 1) om analities die hoë omset polimerase kettingreaksie (RT-PKR) metode te valideer vir die geselekteerde enkel nukleotied polimorfismes (ENPs) FTO rs9939609 (intron 1 T>A), TNF-α rs1800629 (-308 G>A) en PPARγ rs1801282 (Pro12Ala, 34 C>G), en 2) om genotipe-fenotipe assosiasie studies uit te voer ten opsigte van relevante biochemiese abnormaliteite, graad van die siekte en aanvangsouderdom. ’n Totaal van 119 pasiënte met vervette lewers is geïdentifiseer met behulp van ultraklank, insluited 88 histologies-bevestigde NALV pasiënte, en 166 kontrole individue. Hierdie pasiënte is gegenotipeer vir die 3 geselekteerde ENP’s. RT-PKR gevalideer met direkte DNA volgorde bepaling as die goue standaard, is gebruik vir opsporing van genetiese variasie. Al die ENP’s was in Hardy Weinberg ekwilibrium in die studie populasie, behalwe vir ’n afwyking in genotipe verspreiding waargeneem vir PPARγ in die NALV subgroep (p<0.001). Nadat aanpassings gemaak is vir ouderdom en geslag, is die risiko-geassosieerde FTO rs9939609 A-alleel waargeneem teen ’n betekenisvol hoër frekwensie in die Kaukasiese pasiënte in vergelyking met Kleurling pasiënte (p=0.005). Die teenoorgestelde is waargeneem vir die risiko-geassosieerde TNF-α rs1800629 A-alleel wat voorgekom het teen ’n betekenisvol hoër frekwensie in die Kleurling NALV pasiënte, in vergelyking met Kaukasiese NALV pasiënte (p=0.034). Die aanvang van NALV was gemiddeld 5 jaar vroeër in die teenwoordigheid van elke risiko-geassosieerde TNF-α rs1800629 A-alleel (p=0.028). Met inagneming van ’n genotipe risiko telling tussen 0–6, het aanvang van siekte gemiddeld 3 jaar vroeër voorgekom (p=0.008) in die teenwoordigheid van elke toenemende risiko-geassosieerde FTO A-alleel, TNF-α A-alleel en PPARγ C-alleel. Nadat aanpassings gemaak is vir ouderdom, geslag en ras, is geen verskille waargeneem in genotipe verspreiding of alleel frekwensies tussen histologies bevestigde NALV (tipes 1,2) en NASH (tipes 3,4) pasiënte nie, terwyl die minor alleel telling vir die TNF-α rs1800629 betekenisvol hoër was in die totale NALV (tipes 1–4) (p=0.047) asook die NASH subgroep (NALV tipes 3,4) (p=0.03) in vergelyking met vetsugtige pasiënte sonder ’n histologies bevestigde diagnose. ‘n Statisties beteknisvolle korrelasie is verder waargeneem tussen die aantal TNF-α rs1800629 A-allele en toenemende CRP vlakke (p=0.029), met n gunstige verlaagde effek in die teenwoordigheid van lae alcohol gebruik. Die gemiddelde middellyf-omtrek van fisies aktiewe NALV pasiënte was 12% minder as fisies onaktiewe pasiente (p=0.004). Na aanleiding van die resultate van hierdie studie behoort insluiting van geselekteerde ENP’s, en in besonder die pro-inflammatoriese TNF-α rs1800629 polimorfisme, as deel van ’n omvattende kardiovaskulere risiko evaluasie oorweeg te word. Aan die einde van die dag mag vroeë identifikasie van NALV pasiente en effektieve intervensie gebasseer op die onderliggende siekte meganisme, vordering tot NASH verhoed wat getoon is om ’n onafhanklike risiko faktor vir kardiovaskulêre siekte te wees.
Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology
APA, Harvard, Vancouver, ISO, and other styles
5

Chan, Hiu-ting, and 陳曉庭. "The effect of diet intake on vascular function and therapeutic effect of cardiovascular medicine in patients with cardiovascular disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50434342.

Full text
Abstract:
Cardiovascular diseases (CVDs) remain to be the leading causes of morbidity and mortality in Hong Kong and worldwide. Among different modifiable risk factors, dietary pattern is on the major determinant for CVD and overall mortality. Other than pharmacological therapies for cardiovascular risk factors, such as hypertension, hyperlipidemia and diabetes, maintaining a healthy diet is a more sustainable method in general population to prevent CVDs. Current lifestyle intervention in the West countries focus on high intake of fruit and vegetables with more than 400g per day and limited saturated fats with less than 10% of energy, there is very limited data on impact of dietary pattern on CVDs in Chinese. Prior studies among Chinese in Hong Kong have shown that only half of the local population fell within these recommended ranges for fat, saturated fatty acid and cholesterol intakes. Several different dietary patterns have been recommended for CVDs prevention based on: i) food groups, such as Mediterranean diet, the Dietary Approaches to Stop Hypertension (DASH) diet; ii) macronutrients: the low-carbohydrate diet, low glycemic index diet, very-low- fat diet and iii) nutrition or vitamin supplement. However, the effect of different dietary patterns based on modulations of food group, macronutrients and particular micronutrients on vascular structure and function in Chinese subjects is unclear. In the first part of this thesis, the relationships between different dietary pattern and surrogate markers of subclinical atherosclerosis and vascular function in different high risk populations for CVDs were investigated. In Chapter 3, we compared the assessment of dietary pattern in Chinese using different tool, including Food Frequency Questionnaire (FFQ); Dietary Record; and Dietitian assessment. In this study, we demonstrated that suitable dietary assessments tools should be chosen for the assessment of different dietary pattern, according to characteristics of assessments. In Chapter 4, the relationship between the fruit intake and subclinical atherosclerosis as measured by carotid intimal thickness (IMT) was investigated in patient with type II diabetes mellitus (DM). Our results showed that high fruit intake was associated with lower burden of carotid atherosclerosis, independent of level of vitamin intake in patients with type II DM. In Chapter 5, we compared the impact of high carbohydrate diet on arterial stiffness between control subjects without CVDs and patients with high risk for CVDs. Our findings showed that high carbohydrate diet mainly affected patients with established CVDs, and their increased arterial stiffness was associated with an elevation of blood pressure. In Chapter 6, we determined the effect of dietary vitamin intake on oxidative stress in patients with high risk of CVDs. In those high risk patients for CVDs, we demonstrated that increased dietary intake of vitamin A, beta-carotene and alpha tocopherol were associated with decreased oxidative stress, but these relationships were not observed in those control subjects without CVDs. It is likely attributed to the higher systemic oxidative stress levels in patients with high risk of CVDs. On the other hand, food intake may also affect the clinical efficacy of cardiovascular therapies. In particularly, it has been well established that herbal intake which is commonly used by Chinese can affect the anticoagulant effect of warfarin on patients with non-valvular atrial fibrillation (AF). Thus, in this second part of the thesis, we investigated the effect of concomitant herbal intake on anticoagulation control in patients with non-valvular AF treated with warfarin. Our results showed that patients with AF treated with warfarin had limited knowledge on potential interaction between herbal substances in foods and warfarin, in which increased herbal substances intake significantly reduced the percentage time of anticoagulant effect within the therapeutic range. Moreover, a single section of education on knowledge of herbal ingredients did not improve their percentage time of therapeutic range for these patients. In conclusion, these findings suggest that dietary pattern in Chinese might have significant impact of vascular function in patients with type II DM and high risk for CVDs. Moreover, the herbal substances in the diet among Chinese could have significant impact of the therapeutic effects in some of the cardiovascular medications, such as warfarin. Future clinical studies will be needed to confirm these potential beneficial effects of particular diet intake on vascular function in patients with high risks of CVDs as well as potential interaction between herbal substances in Chinese diet and cardiovascular medications.
published_or_final_version
Medicine
Doctoral
Doctor of Philosophy
APA, Harvard, Vancouver, ISO, and other styles
6

Chow, Wai-sum, and 周瑋琛. "A systematic review on the role of chocolate in the prevention of cardiovascular diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47560198.

Full text
Abstract:
Background: Research studies in recent years suggested possible role of dark chocolate in preventing cardiovascular diseases due to its high flavonal and procyanidins contents. Whether there is clear clinical benefit and the mechanisms mediating such benefits is controversial. Objective: This systematic review aims to comprehensively examine the current clinical evidence regarding effectiveness and the possible mechanisms of chocolate in reducing the risk and / or surrogate markers of cardiovascular diseases. Methods: Comprehensive electronic literature search was performed using Ovid, Medline and Cochrane database. Only English language literatures published during year 1950 - 2010 were reviewed. All intervention studies and observational studies of adult human subjects taking white or dark chocolate in relation to outcomes of cardiovascular risk were included. All review articles and meta-analysis were also included. Clinical diagnosis of cardiovascular disease and surrogate markers including blood pressure, vascular endothelial function as measured by flowed mediated vasodilation, and blood biomarkers such as lipid profile were studied as outcome variables. Results: The review outlines recent observational and interventional studies and meta-analysis to give an overview of the topic. For observational studies, a cohort studies and two case control studies were found. The observational studies showed that dark chocolate consumption was inversely associated with blood pressure, cardiovascular mortality and C-reactive protein. All interventional studies searched showed that dark chocolate increased FMD and improved platelet function. However, the effects of cocoa on intermediate outcomes such as blood pressure, antioxidant capacity and inflammatory marker changes were inconsistent among interventional studies. Three interventional studies indicated that there was a dose-dependent improvement in immediate outcome variables after 1 month or even 2 hours acute consumption of dark chocolate with procyanidins or cocoa drink with flavonol. However, publication bias and potential conflict of interests may be a potentially important factor in interpreting study results in the current literature. Conclusions: There are some clinical and scientific evidences that consumption of dark chocolate produces positive cardiovascular benefits. A small amount of dark chocolate may be good for the heart. However, gaps in our knowledge such as a lack of long-term RCT in clinical outcomes must be filled in before recommending habitual dark chocolate consumption for reduction of cardiovascular risk.
published_or_final_version
Community Medicine
Master
Master of Public Health
APA, Harvard, Vancouver, ISO, and other styles
7

Ng, Kuen-to, and 伍權韜. "The gender difference and association between social position and cardiovascular risk factors in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45012775.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Chen, Hua, and 陳華. "Relationship between psychological status and vascular function in subjects with and without cardiovascular diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290409.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Cai, Wenjun, and 蔡文珺. "A review of the association between occasional and moderate alcohol consumption and cardiovascular disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206907.

Full text
Abstract:
Objective: The review aims to evaluate associations of occasional and moderate drinking with cardiovascular diseases (CVD), specifically to compare results for occasional and moderate drinking, as moderate drinking is widely investigated while occasional drinking is relatively understudied and can potentially inform whether alcohol is causally related to CVD. Methods: A systematic review was conducted by searching for observational and interventional studies from three databases (ScienceDirect, Ebscohost, and PubMed) for alcohol consumption and its association with cardiovascular health. Online internet sources were also used for more supplementary research in this literature review. Patient-oriented outcomes, primarily on heart diseases, including cardiovascular heart disease, myocardial infarction, and coronary heart disease, were extracted from all study groups. Results: Fifteen studies were included, most of which were conducted in the United States of America (9 studies). Generally, moderate alcohol consumption is associated with a reduction in CVD risks, including extensive coronary calcification, sudden cardiac death, congestive heart failure, acute coronary syndrome, ischemic heart disease. Studies also suggests that alcohol may be associated with better endothelial function and lower systolic blood pressure Current occasional alcohol use is found to be associated lower IHD mortality in men, but is not related to IHD mortality in women. Conclusion: We found consistent evidence of protective association of moderate alcohol consumption against cardio-mortality and CVD, while occasional alcohol consumption has relatively less protection against CHD deaths. Such associations were only found in studies with living controls. Only a small number of studies have studied occasional drinking, in relation to cardiovascular health. Further studies that specifically examine occasional drinking, are needed. If the biological effects of occasional drinking towards CVD are limited, then occasional drinking may indicate the magnitude of residual and unobserved confounding in the association with cardiovascular health. This will in turn inform alcohol-related policies such as alcohol duties and minimum alcohol pricing.
published_or_final_version
Public Health
Master
Master of Public Health
APA, Harvard, Vancouver, ISO, and other styles
10

Henning, Andrea L. "Monitoring Monocyte Oxldl Phagocytosis As a Cardiovascular Disease Risk Factor Following a High-fat Meal." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc700101/.

Full text
Abstract:
Macrophage-derived foam cells play a predominant role in the deposition of arterial plaques during the early stages of atherosclerosis. The deposition of arterial plaques is known to be effected by several factors, including a person’s dietary habits. The consumption of a high-fat (>60% of calories from fat) meal is known to elevate serum LDL and triglycerides, which have been previously implicated in the formation pf foam cells. One limitation of current research models is that it is not possible to directly measure foam cells in vivo. Thus, the purpose of the present study was to validate the use of blood derived monocytes as a proxy measure of foam cells. In order to complete this objective, we evaluated monocyte oxLDL phagocytosis capacity following consumption of a high-fat meal. Eight men and women participated in the present study and venous blood samples were collected prior to the meal, 1-h, 3-h, and 5-h post-meal. Monocytes (CD14+/16- and CD14+/16+) were evaluated for adhesion molecule expression (CD11a, CD11b, and CD18), scavenger R (CD36) expression, and oxLDL phagocytosis using an image-based flow cytometry method developed in our laboratory for this purpose. Data was statistically analyzed for significance using a single-factor ANOVA with repeated measures and a p < 0.05. Consumption of a high-fat meal caused an increase significant increase in the proportion of pro-inflammatory monocytes (CD14+/16+) and a decrease in classic monocytes (CD14+/16-), with the greatest difference occurring at 5 h post prandial (p = 0.038). We also found that pro-inflammatory monocyte expression of adhesion molecules and CD36 increased in a manner that would promote in vivo movement of monocytes into the subendothelial space. Finally, over the course of the 5 h postprandial period, the majority of oxLDL uptake occurred in pro-inflammatory compared to classic monocytes. These results suggest that consuming a high-fat meal increases the potential of monocytes to become foam cells for at least 5 h postprandial.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Cardiovascular system – Diseases – Genetic aspects"

1

Genes and cardiovascular function. New York: Springer, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Sinagra, Gianfranco, F. Camerini, and Luisa Mestroni. Genetic cardiomyopathies: A clinical approach. Milan: Springer, 2013.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Kåre, Berg, and Nora Audrey Hart 1936-, eds. Cardiovascular diseases: Genetics, epidemiology, and prevention. New York: Oxford University Press, 1991.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Molecular cardiology for the cardiologists. Boston: Kluwer Academic Publisher, 1995.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Baars, H. F. Clinical Cardiogenetics. London: Springer-Verlag London Limited, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

A, Doevendans Pieter, and Kääb Stefan 1963-, eds. Cardiovascular genomics: New pathophysiological concepts : proceedings of the 2001 European Science Foundation Workshop in Maastricht. Boston: Kluwer Academic Publishers, 2002.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Cardiovascular genomics: Methods and protocols. New York, N.Y: Humana Press, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Cardiovascular disease in racial and ethnic minorities. Totowa, N.J: Humana, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Molecular cardiology for the cardiologist. 2nd ed. Boston: Kluwer Academic, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Dhalla, Naranjan S. Molecular defects in cardiovascular disease. Edited by Ošt̕ádal Bohuslav. New York: Springer, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Cardiovascular system – Diseases – Genetic aspects"

1

Benetos, Athanase, Abraham Aviv, Patrick Lacolley, Michel E. Safar, and Véronique Regnault. "Genetic and Cellular Aspects of Arterial Stiffness." In Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases, 83–94. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-5198-2_8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Girolami, Jean-Pierre, Nelly Blaes, Nadine Bouby, and François Alhenc-Gelas. "Genetic Manipulation and Genetic Variation of the Kallikrein-Kinin System: Impact on Cardiovascular and Renal Diseases." In Recent Developments in the Regulation of Kinins, 145–96. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06683-7_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Bredella, Miriam A., and Bruno C. Vande Berg. "Metabolic-Endocrine." In IDKD Springer Series, 169–82. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71281-5_12.

Full text
Abstract:
AbstractAll components of the musculoskeletal system can be involved by metabolic disorders as a result of endocrine diseases, genetic alterations, and environmental or nutritional aspects, with important worldwide variations in prevalence and severity. Early detection of these disorders is crucial because of the efficacy of preventive measures and availability of treatments. The current chapter will focus on the imaging appearance of metabolic disorders of bone marrow and of the mineralized skeleton. Marrow and bone disorders in athletes, the elderly, and individuals with eating disorders will be reviewed.
APA, Harvard, Vancouver, ISO, and other styles
4

"Renin-Angiotensin System and Cardiovascular Physiology." In New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases, edited by Maria Cláudia Irigoyen, Kátia De Angelis, Ivana Cinthya de Moraes da Silva, Silvia Lacchini, Janaina Barcellos Ferreira, Kátia Bilhar Scapini, and Fernanda Marciano Consolim-Colombo, 45–78. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681083131116010006.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

"Renin Receptors in Cardiovascular and Renal Diseases." In New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases, edited by A. H. Jan Danser, 217–31. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681083131116010014.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

"Renin Angiotensin System: Old System with New Different Components." In New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases, edited by Danielle Yuri Arita, Rosana Inácio dos Reis, Bruno Sevá Pessôa, and Dulce Elena Casarini, 3–14. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681083131116010004.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

"Cardiac Intracellular Renin-Angiotensin System." In New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases, edited by Rajesh Kumar, Kenneth M. Baker, Wen Chen, Larissa Miranda Pereira, Candice M. Thomas, and Qian Chen Yong, 79–91. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681083131116010007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

"Exercise and Renin Angiotensin System." In New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases, edited by Tatiana Sousa Cunha, Kleiton Augusto Santos Silva, Andrea Sanches, Sebastiao Donato Silva Jr., Vanessa Oliveira, Lilia Firoozmand, Fernanda Klein Marcondes, and Lisete C. Michelini, 275–321. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681083131116010017.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

"ACE Gene “Dosage” and Cardiovascular and Renal Disease." In New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases, edited by José Geraldo Mill, Alexandre Costa Pereira, Rebeca Caldeira Machado, Ludimila Forechi, Marcelo Perim Baldo, and José Eduardo Krieger, 175–93. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681083131116010012.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Raghavapanicker Sanal Kumar, Valsalayam, Shiv Kumar Choudhary, Pradeep Kumar Radhakrishnan, Rajaghatta Sundararam Bharath, Nichith Chandrasekaran, Vigneshwaran Sankar, Ajith Sukumaran, and Charlie Oommen. "Internal Flow Choking in Cardiovascular System: A Radical Theory in the Risk Assessment of Asymptomatic Cardiovascular Diseases." In Cardiac Diseases - Novel Aspects of Cardiac Risk, Cardiorenal Pathology and Cardiac Interventions. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96987.

Full text
Abstract:
The theoretical discovery of Sanal flow choking in the cardiovascular system (CVS) demands for interdisciplinary studies and universal actions to propose modern medications and to discover new drugs to annul the risk of flow-choking leading to shock-wave generation causing asymptomatic-cardiovascular-diseases. In this chapter we show that when blood-pressure-ratio (BPR) reaches the lower-critical-hemorrhage-index (LCHI) the flow-choking could occur in the CVS with and without stent. The flow-choking is uniquely regulated by the biofluid/blood-heat-capacity-ratio (BHCR). The BHCR is well correlated with BPR, blood-viscosity and ejection-fraction. The closed-form analytical models reveal that the relatively high and the low blood-viscosity are cardiovascular-risk factors. In vitro data shows that nitrogen, oxygen, and carbon dioxide gases are predominant in fresh blood samples of the human being/Guinea-pig at a temperature range of 37–40 °C (98.6–104 °F). In silico results demonstrate the occurrence of Sanal flow choking leading to shock wave generation and pressure-overshoot in CVS without any apparent occlusion. We could conclude authoritatively, without any ex vivo or in vivo studies, that the Sanal flow choking in CVS leads to asymptomatic-cardiovascular-diseases. The cardiovascular-risk could be diminished by concurrently lessening the viscosity of biofluid/blood and flow-turbulence by increasing the thermal-tolerance level in terms of BHCR and/or by decreasing the BPR.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Cardiovascular system – Diseases – Genetic aspects"

1

Rastgar Agah, Mobin, Kaveh Laksari, Kurosh Darvish, and Alexander Rachev. "Buckling of Porcine Aorta Under Static and Dynamic Loading." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80931.

Full text
Abstract:
Tortuosity and buckling of blood vessels are defined as the deviation from original configuration and has been observed throughout the vascular system. The blood flow in the regions down-stream of tortuous section decreases, which may cause a deficiency in blood supply to the organs and ischemia. Although tortuosity of blood vessels has been associated with aging, atherosclerosis, hypertension, genetic and other cardiovascular disease, the mechanism behind its initiation and development is not yet understood. In a series of theoretical and experimental studies, biomechanical aspects of buckling of arteries has been investigated under quasi-static loading (Han, 2007; Liu and Han, 2011); however, it has been shown theoretically that the buckling behavior of arteries under dynamic loading are different and arteries may become mechanically unstable at pressures other than the static critical loading (Rachev, 2009). This work addresses buckling of porcine aorta and experimental verification of dynamic buckling in this case. We hypothesize that dynamic buckling can partly contribute to the traumatic rupture of aorta that is a leading cause of fatality in motor vehicle crashes.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Cardiovascular system – Diseases – Genetic aspects' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography