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1

1948-, Hieble Jacob Paul, ed. Cardiovascular function of peripheral dopamine receptors. New York: M. Dekker, 1990.

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2

1934-, Grobecker Horst, Philippu Athineos 1931-, Starke Klaus 1937-, and Schümann Hans-Joachim 1919-, eds. New aspects of the role of adrenoceptors in the cardiovascular system: Festschrift in honour of the 65th birthday of Prof. Dr. Hans-Joachim Schümann. Berlin: Springer-Verlag, 1986.

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3

van, Zwieten P. A., Schönbaum E, and Dutch Pharmacological Society, eds. Receptors in the cardiovascular system: Proceedings of a symposium. Stuttgart ; New York: G. Fischer, 1986.

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4

Kelly, J. G. Adrenergic receptors in the cardiovascular system: A review of their physiology and pharmacology. London: Rorer International Pharmaceuticals, 1986.

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5

Laboratory, Cold Spring Harbor, and Cold Spring Harbor Symposium on Quantitative Biology (67th : 2002), eds. Abstracts of papers presented at the 67th Cold Spring Harbor Symposium on Quantitative Biology: The cardiovascular system, May 29-June 3, 2002. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory, 2002.

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6

Gesellschaft für Fortschritte auf dem Gebiet der Inneren Medizin. Symposium. Cardiovascular receptors: New pharmacological and clinical aspects : 18th Symposium of the Gesellschaft für Fortschritte auf dem Gebiet der Inneren Medizin, Düsseldorf, December 1984 (chairman: Paul Schölmerich with collaboration of Erland Erdmann and Hasso Scholz). Stuttgart: G. Thieme, 1986.

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7

Laboratory, Cold Spring Harbor, ed. The cardiovascular system. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2002.

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8

Kutikhin, Anton G. Genomics of pattern recognition receptors: Applications in oncology and cardiovascular diseases. Basel: Springer, 2013.

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9

van, Zwieten P. A., and Schönbaum E, eds. Receptors in the cardiovascular system: Proceedings of a symposium, organized by the Dutch Pharmacological Society in OSS, the Netherlands, May 31, 1985. New York: G. Fischer Varlag, 1986.

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10

Ahsan, Husain, Graham Robert M, and Victor Chang Cardiac Research Institute., eds. Drugs, enzymes, and receptors of the renin-angiotensin system: Celebrating a century of discovery. Amsterdam: Harwood Academic Publishers, 2000.

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11

Lars, Edvinsson, and Uddman Rolf, eds. Vascular innervation and receptor mechanisms: New perspectives. San Diego: Academic Press, 1993.

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12

P, Soares-da-Silva, ed. Cardiovascular and renal actions of Dopamine: Proceedings of the IVth International Conference on Peripheral Dopamine held in Porto, Portugal on 18-20 June 1992. Oxford, England: Pergamon Press, 1993.

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13

Murphy, Natalie P. Coronary thrombosis and thrombolysis: The role of platelet glycoprotein IIb/IIIa. Dublin: University College Dublin, 1996.

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14

Dominique, Bagnard, ed. Neuropilin: From nervous system to vascular and tumor biology. New York: Kluwer Academic/Plenum Pub., 2002.

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15

Dominique, Bagnard, ed. Neuropilin: From nervous system to vascular and tumor biology. New York: Kluwer Academic/Plenum Pub., 2002.

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16

Dominique, Bagnard, ed. Neuropilin: From nervous system to vascular and tumor biology. New York: Kluwer Academic/Plenum Pub., 2002.

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17

1937-, Kanno Morio, and Hattori Yuichi, eds. Current aspects of cellular and subcellular mechanism of drug actions. Sapporo, Japan: Hokkaido University School of Medicine, 2000.

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18

1930-, Bevan John A., ed. Vascular neuroeffector mechanisms: Receptors, ion-channels, second messengers, and endogenous mediators : proceedings of the Sixth International Symposium on Vascular Neuroeffector Mechanisms, Melbourne, Australia, August 30-September 2, 1987. Oxford: Published for the ICSU Press by IRL Press, 1988.

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19

Michael, Lincoff A., and Topol Eric J. 1954-, eds. Platelet glycoprotein IIb/IIIa receptor inhibitors in cardiovascular disease. Totowa, N.J: Humana Press, 1999.

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20

Prichard, Brian N. C. 1932-, ed. Beta-blockers in clinical practice. Edinburgh: Churchill Livingstone, 1987.

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21

Cruickshank, J. M. Beta-blockers in clinical practice. Edinburgh: Churchill Livingstone, 1988.

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22

R, Bühler Fritz, ed. The Cardioselectivity of bisoprolol. Montreal: PharmaLibri, 1989.

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23

Burnstock, Geoffrey, Joel Linden, James G. Dobson Jr, and Bruce T. Liang. Cardiovascular Biology of Purines. Springer London, Limited, 2012.

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24

Burnstock, Geoffrey, Joel Linden, James G. Dobson Jr, and Bruce T. Liang. Cardiovascular Biology of Purines. Springer London, Limited, 2012.

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25

al, et, and P. Schoelmerich. Cardiovascular Receptors: New Pharmacological and Clinical Aspects. Thieme Publishing Group, 1987.

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26

Erdmann, Erland, R. Jacob, and W. Schaper. Cardiac Glycoside Receptors and Positive Inotropy: Evidence for More Than One Receptor? - Symposium, Munich, October 26-29 1983. Steinkopff, Dietrich, 2011.

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27

Erdmann, Erland, R. Jacob, and W. Schaper. Cardiac Glycoside Receptors and Positive Inotropy: Evidence for more than one receptor? Symposium, Munich, October 26-29, 1983. Steinkopff, 2011.

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28

Harbor, Cold Spring. The Cardiovascular System (Cold Spring Harbor Symposia on Quantitative Biology. Cold Spring Harbor Laboratory Press, 2003.

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29

Harbor, Cold Spring. Cardiovascular System (Cold Spring Harbor Symposia on Quantitative Biology. Cold Spring Harbor Laboratory Press, 2003.

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30

Zwieten, P. A. Van. Receptors in the Cardiovascular System (Progress in Pharmacology and Clinical Pharmacology). Lubrecht & Cramer, Limited, 1986.

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31

Hieble, Paul J. Cardiovascular Function of Peripheral Dopamine Receptors (Clinical Pharmacology, Vol 15). CRC, 1989.

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32

Kutikhin, Anton G., and Arseniy E. Yuzhalin. Genomics of Pattern Recognition Receptors: Applications in Oncology and Cardiovascular Diseases. Springer Basel AG, 2015.

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33

DeMello, Walmor C., and Edward D. Frohlich. Renin Angiotensin System and Cardiovascular Disease. Humana Press, 2012.

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34

Prostaglandins in clinical research, cardiovascular system: Proceedings of the Fourth International Symposium on Prostaglandins : Cardiovascular system ... in clinical and biological research). Liss, 1989.

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35

Junien, J. L. Nuclear Receptors As Molecular Targets for Cardiometabolic and Central Nervous System Diseases. IOS Press, Incorporated, 2008.

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36

E.E. van der Wall (Editor), P. K. Blanksma (Editor), M. G. Niemeyer (Editor), and A. M. Paans (Editor), eds. Cardiac Positron Emission Tomography: Viability, Perfusion, Receptors and Cardiomyopathy (Developments in Cardiovascular Medicine). Springer, 1995.

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37

Xander H. T. Wehrens (Editor) and Andrew R. Marks (Editor), eds. Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine). Springer, 2004.

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38

Sheridan, Peter J., and Kenneth Blum. Steroid Receptors and Disease: Cancer, Autoimmune, Bone, and Circulatory Disorders. Marcel Dekker Inc, 1988.

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39

Husain, Ahsan, and Robert M. Graham. Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery. Taylor & Francis Group, 2003.

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40

Husain, Ahsan, and Robert M. Graham. Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery. Taylor & Francis Group, 2000.

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41

Husain, Ahsan, and Robert M. Graham. Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery. Taylor & Francis Group, 2003.

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42

Graham, Robert M., and Ahsan Husain. Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery (The Victor Chang Molecular Cardiology Series, V. 1). CRC, 2000.

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43

Lambert, David G. Mechanisms and determinants of anaesthetic drug action. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0013.

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This chapter is broken into two main sections: a general description of the principles of ligand receptor interaction and a discussion of the main groups of ‘targets’; and explanation of some common pharmacological interactions in anaesthesia, critical care, and pain management. Agonists bind to and activate receptors while antagonists bind to receptors and block the effects of agonists. Antagonists can be competitive (most common) or non-competitive/irreversible. The main classes of drug target are enzymes, carriers, ion channels, and receptors with examples of anaesthetic relevance interacting with all classes. There are many examples in anaesthesia where multiple interacting drugs are co-administered—polypharmacology. To give an example: neuromuscular blockade. Rocuronium is a non-depolarizing neuromuscular blocker acting as a competitive antagonist at the nicotinic acetylcholine receptor. Rocuronium competes with endogenous acetylcholine to shift the concentration–response curve for contraction to the right. The degree of contractility is less for a given concentration of acetylcholine (agonist) in the presence of rocuronium. Using the same principle, the rightward shift can be compensated by increasing the amount of acetylcholine (as long as the amount of rocuronium presented to the receptor as an antagonist remains unchanged, its action can be overcome by increased agonist). Acetylcholine at the effect site is increased by acetylcholinesterase inhibition with neostigmine. One of the side-effects of neostigmine is that it acts as an indirect parasympathomimetic. In the cardiovascular system this would lead to muscarinic receptor-mediated bradycardia; these effects are routinely reversed by the competitive muscarinic antagonist glycopyrrolate.
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44

Cardiogenic reflexes: Report of an international symposium organized by the Department of Cardiovascular Studies, University of Leeds, and held in Leeds, 16-20 September 1985. Oxford: Oxford University Press, 1987.

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45

Dhaun, Neeraj, and David J. Webb. Endothelins and their antagonists in chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0114_update_001.

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The endothelins (ETs) are a family of related peptides of which ET-1 is the most powerful endogenous vasoconstrictor and the predominant isoform in the cardiovascular and renal systems. The ET system has been widely implicated in both cardiovascular disease and chronic kidney disease (CKD). ET-1 contributes to the pathogenesis and maintenance of hypertension and arterial stiffness, as well endothelial dysfunction and atherosclerosis. By reversal of these effects, ET antagonists, particularly those that block ETA receptors, may reduce cardiovascular risk. In CKD patients, antagonism of the ET system may be of benefit in improving renal haemodynamics and reducing proteinuria, effects seen both in animal models and in some human studies. Data suggest a synergistic role for ET receptor antagonists with angiotensin-converting enzyme inhibitors in lowering blood pressure, reducing proteinuria, and in animal models in slowing CKD progression. However, in clinical trials, fluid retention or cardiac failure has caused concern and these agents are not yet ready for general use for risk reduction in CKD.
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46

The Imidazoline Receptor: Pharmacology, Functions, Ligands, and Relevance to Biology and Medicine (Annals of the New York Academy of Sciences, V. 763). New York Academy of Sciences, 1995.

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47

(Editor), J. A. Bevan, H. Majewski (Editor), R. A. Maxwell (Editor), and D. F. Story (Editor), eds. Vascular Neuroeffector Mechanisms: Receptors, Ion-Channels, Second Messengers and Endogenous Mediators (Icsu Symposium Series, Vol 10). Oxford University Press, USA, 1988.

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48

Neuropilin: From Nervous System to Vascular and Tumor Biology (Advances in Experimental Medicine and Biology). Springer, 2007.

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49

Bagnard, Dominique. Neuropilin: From Nervous System to Vascular and Tumor Biology. Springer, 2012.

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50

Bagnard, Dominique. Neuropilin: From Nervous System to Vascular and Tumor Biology. Springer London, Limited, 2011.

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