Relevant bibliographies by topics / Cardiosphere-derived cell

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Cardiosphere-derived cell'

Author: Grafiati
Published: 11 March 2023

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Journal articles on the topic "Cardiosphere-derived cell"

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Emani, Sitaram M., and Pedro J. del Nido. "Cell-Based Therapy With Cardiosphere-Derived Cardiocytes." Circulation Research 122, no. 7 (March 30, 2018): 916–17. http://dx.doi.org/10.1161/circresaha.118.312809.

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Dergilev, K. V., Z. I. Tsokolaeva, Yu D. Vasilets, I. B. Beloglazova, and E. V. Parfenova. "Cardiac progenitor cell sheets secrete proangiogenic growth factors and locally activate capillarogenesis after infarction." Complex Issues of Cardiovascular Diseases 10, no. 3 (September 25, 2021): 34–43. http://dx.doi.org/10.17802/2306-1278-2021-10-3-34-43.

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Background. The application of tissue-engineered constructs that simulate the natural microenvironment of cells, maintain their viability and functional properties, is a new promising route for the treatment of ischemic diseases. However, the mechanisms that ensure the effectiveness of this type of treatment and the principles of choosing the optimal population of progenitor cells remain poorly understood. Aim. To study the profile of secretion of proangiogenic growth factors of cardiosphere-derived cell sheet (CS), and to study the effect of their transplantation on postinfarction myocardial vascularization. Methods. Assembly of cardiosphere-derived cell sheets were performed on thermosensitive culture plates. Characterization of cell sheets was performed using immunofluorescence staining and a commercial kit for the determination of proangiogenic factors “Mouse Angiogenesis Antibody Array”. The evaluation of the angiogenic properties of the cell graft in vivo was carried out using a rat myocardial infarction model. Results. It was found that the cardiosphere-derived cell sheet secrete factors involved in the regulation of vasculo-/angiogenesis. At the same time, the cultivation of cell sheets under hypoxic conditions (3% O2) led to an increase in the secretion of proangigenic factors VEGF and pIgF, fGf-1, FGF-2, endothelin-1, as well as MMP-9, which is involved in extracellular matrix remodeling. Cell sheet transplantation on the epicardial surface of the heart after myocardial infarction ensures cell viability and local increase in capillarization of the damaged area. Conclusion. Thus, the application of cardiosphere-derived cell sheets, which have proangiogenic properties and ability to maintain post transplantation cell survival, can be considered as a promising approach for the development of new methods of therapy for heart diseases
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Pakzad, Khadijeh Kathy, Jun Jie Tan, Stephanie Anderson, Mary Board, Kieran Clarke, and Carolyn A. Carr. "Metabolic maturation of differentiating cardiosphere-derived cells." Stem Cell Research 54 (July 2021): 102422. http://dx.doi.org/10.1016/j.scr.2021.102422.

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Chen, Lijuan, Muhammad Ashraf, Yingjie Wang, Mi Zhou, John Zhang, Gangjian Qin, Jack Rubinstein, Neal L. Weintraub, and Yaoliang Tang. "The Role ofNotch 1Activation in Cardiosphere Derived Cell Differentiation." Stem Cells and Development 21, no. 12 (August 10, 2012): 2122–29. http://dx.doi.org/10.1089/scd.2011.0463.

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Xie, Yucai, Ahmed Ibrahim, Ke Cheng, Zhijun Wu, Wenbin Liang, Konstantinos Malliaras, Baiming Sun, et al. "Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells." STEM CELLS 32, no. 9 (August 18, 2014): 2397–406. http://dx.doi.org/10.1002/stem.1736.

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Martens, Andreas, Ina Gruh, Dimitrios Dimitroulis, Sebastian V. Rojas, Ingrid Schmidt-Richter, Christian Rathert, Nawid Khaladj, et al. "Rhesus monkey cardiosphere-derived cells for myocardial restoration." Cytotherapy 13, no. 7 (August 2011): 864–72. http://dx.doi.org/10.3109/14653249.2011.571247.

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Marbán, Eduardo. "Breakthroughs in Cell Therapy for Heart Disease: Focus on Cardiosphere-Derived Cells." Mayo Clinic Proceedings 89, no. 6 (June 2014): 850–58. http://dx.doi.org/10.1016/j.mayocp.2014.02.014.

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Fujita, Akira, Koji Ueno, Toshiro Saito, Masashi Yanagihara, Hiroshi Kurazumi, Ryo Suzuki, Akihito Mikamo, and Kimikazu Hamano. "Hypoxic-conditioned cardiosphere-derived cell sheet transplantation for chronic myocardial infarction." European Journal of Cardio-Thoracic Surgery 56, no. 6 (April 24, 2019): 1062–74. http://dx.doi.org/10.1093/ejcts/ezz122.

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Abstract OBJECTIVES Cell therapy provides a suitable environment for regeneration through paracrine effects such as secretion of growth factors. Cardiosphere-derived cells (CDCs) have a high capacity for growth factor secretion and are an attractive target for clinical applications. In particular, a cell sheet technique was reported to have clinical advantages by covering a specific region. Here, we examined the effect of the hypoxic-conditioned (HC) autologous CDC sheet therapy on a rabbit chronic myocardial infarction model. METHODS CDC sheet function was assessed by the enzyme-linked immunosorbent assay and quantified by polymerase chain reaction in vitro (days 1–3 of conditioning). The rabbit chronic myocardial infarction model was established by left coronary ligation. Autologous CDCs were isolated from the left atrial specimen; CDC sheets with or without 2-day HC were transplanted onto the infarcted hearts at 4 weeks. The cardiac function was assessed by an echocardiography at 0, 4 and 8 weeks. A histological analysis of the host hearts was performed by tomato lectin staining at 8 weeks. RESULTS The optimal HC duration was 48 h. HC significantly increased the mRNA expression levels of VEGF and ANG2 on day 2 compared to the normoxic-conditioned (NC) group. The HC group showed significant improvement in the left ventricular ejection fraction (64.4% vs 58.8% and 53.4% in the NC and control) and a greater lectin-positive area in the ischaemic region (HC:NC:control = 13:8:2). CONCLUSIONS HC enhances the paracrine effect of a CDC sheet on angiogenesis to improve cardiac function in the chronic myocardial infarction model, which is essential for cardiomyocyte proliferation during cardiac regeneration.
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Bruyneel, Arne, Rabia Nazir, Qi Chen, Colleen Lopez, Jan Czernuszka, and Carolyn Carr. "164 Cardiosphere-Derived Cell-Seeded Porous Collagen Scaffolds for Cardiac Repair." Heart 102, Suppl 6 (June 2016): A116.1—A116. http://dx.doi.org/10.1136/heartjnl-2016-309890.164.

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Grigorian-Shamagian, Lilian, Weixin Liu, Soraya Fereydooni, Ryan C. Middleton, Jackelyn Valle, Jae Hyung Cho, and Eduardo Marbán. "Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats." European Heart Journal 38, no. 39 (August 14, 2017): 2957–67. http://dx.doi.org/10.1093/eurheartj/ehx454.

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Dissertations / Theses on the topic "Cardiosphere-derived cell"

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Mentkowski, Kyle Indiana Robert. "Development of a targeted cardiomyocyte delivery system utilizing cardiosphere-derived cell exosomes." Thesis, State University of New York at Buffalo, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10279148.

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Cardiovascular disease continues to be the leading cause of mortality and morbidity in the United States. Current treatment options are aimed at preventing additional injury and helping the heart work more efficiently, but are limited in their regenerative capacity. Recently, research has shown that treating the heart with various stem cell populations, including cardiosphere-derived cells (CDCs), post myocardial infarction (MI) stimulates regeneration, angiogenesis, and functional improvement. While this treatment has shown promise in early stage clinical trials, there remains a gap in the ability to efficiently deliver tissue-specific agents directly to the heart while avoiding nonspecific delivery to other organs. To fully realize the therapeutic potential of efficient delivery to the heart, we engineered CDC-derived exosomes (nano-vesicles that transport RNA and protein between cells) to express Lamp-2b, an exosomal trans-membrane protein, fused with a cardiomyocyte-specific peptide. Preliminary experiments showed enhanced exosome uptake by cardiomyocytes in vitro, establishing a novel tool for targeted delivery of anti-apoptotic drug and gene therapy.

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Tan, J. J. "Cardiosphere-derived stem cell culture, characterisation and labelling for in vivo testing in the infarcted heart." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d902b4f4-6e32-45dd-9767-8e0a17967393.

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Cardiac stem cells (CSCs), isolated from heart tissue explants and expanded via the formation of cardiospheres (Csp), are a promising candidate for cell therapy to prevent heart failure following myocardial infarction. To allow early administration to patients, isolation and expansion of CSCs must be performed in the shortest time possible. Hence, this project aimed to optimize culture conditions and characterize the cardiac explant-derived cells (EDCs), Csp and Csp-derived cells (CDCs) produced. Rat neonatal EDCs contained 4-7% c-kit+ cells, measured using flow cytometry. Optimal Csp growth conditions were determined, such that plating 3 x 10^4 EDCs per well of a 24-well plate coated with 16.7 µg/ml poly-D-lysine, in CGM containing 7% serum, improved Csp production and generated 1.5 x 10^7 CDCs in 16 days, a sufficient number for cell therapy. The CDCs expressed the stemness markers; c-kit, Oct3/4, SOX2, and Klf-4, and the cardiac differentiation markers; GATA4 and Nkx2.5. The therapeutic effect of CDCs may be limited by the low, 3 ± 0.1%, c-kit+ cell numbers. To increase c-kit+ cells in CDCs, an alternate culture method for Csp and different extracellular matrices (ECM) for cell expansion were tested. The hanging drop culture method produced Csp with higher levels of c-kit+ cells (9 ± 2%) than poly-D-lysine-coated and low-bind culture dishes. Of five ECM tested, collagen IV was found to enhance EDC migration and CDC proliferation, and produced 11 ± 0.4% c-kit+ cells, with Csp cultured in hanging drops. Intramyocardial injection of CDCs improved left ventricular ejection fractions of infarcted rat hearts by 9% and prevented the peri-infarct wall from thinning, measured in vivo using MRI over 16 weeks. To improve cell tracking using MRI, two MR positive contrast agents, gadolinium-DTPA and gadonanotubes were tested. Gd-DTPA had low sensitivity after labelling (1.4 x 10^5 cells/mm2); whereas gadonanotubes did not provide positive contrast at 11.7 T. Thus, neither contrast agent could be used for cell tracking using high magnetic field. In conclusion, CDCs were an effective source of stem cells that could be used for heart repair, although cells could not be tracked using positive MR contrast.
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Gnutzmann, Daniel [Verfasser], and Christoph [Akademischer Betreuer] Garlichs. "Growing Cardiospheres and Cardiosphere Derived Cells and Characterization there of by FACS Analysis / Daniel Markus Gnutzmann. Betreuer: Christoph Garlichs." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2013. http://d-nb.info/1033030058/34.

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Amirrasouli, Muhammad Mehdi. "Characterisation of cardiosphere derived cells : investigating hypoxic pre-conditioning on pro-angiogenic properties and tracking the cardiac fibroblast component." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2570.

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Coronary heart disease is still the leading cause of death in the UK, despite significant advances in clinical treatments. Stem cell transplantation has the potential to improve cardiac function and patient outcome, but optimal cell types, cell preparation methods and cell delivery routes are yet to be established. The heart contains a small population of progenitor cells that, in culture, contribute to spontaneously formed spheroids known as cardiospheres (Csphs). Following further culture, Csphs give rise to cardiosphere derived cells (CDCs). Both Csphs and CDCs show paracrine benefit including neovascularisation in myocardial ischaemia, leading to improvement in heart function. The aims of this project were to use mouse models to (i) investigate the effect of hypoxic preconditioning on the pro-angiogenic potential of CDCs and (ii) characterise the contribution of cardiac fibroblasts (CFs) to CDCs. I used Col1a2-CreERT;Rosa26-STOP-YFP mice to track YFP-expressing CFs in myocardial tissue and in CDC culture. Co-staining experiments showed only partial overlap of YFP with other CF markers (vimentin and Fsp1) in heart tissue, which may be due to the heterogeneity of CFs and/or incomplete activation of YFP in CFs. I showed that CF-derived cells exist in all stages of CDC culture, and a small subset of these cells also expressed the stem cell markers Sca-1 or cKit, suggesting CF derived cells may contribute to the progenitor cell population. My results showed that preconditioning CDCs with 3%O2 enhances cell outgrowth from heart explants and promotes expression of stem cell and pro-angiogenic markers. I then assessed the pro-angiogenic potential of CDCs in vivo using a sub-dermal matrigel plug assay and showed that CDCs alone have limited pro-angiogenic potential. However, 3%O2 preconditioning of CDCs significantly enhances this process. Further research will increase our understanding of CDC-mediated angiogenesis and improve clinical therapies for MI patients.
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Guo, Xiaolei. "Engineering electrospun scaffolds to treat myocardial infarction." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343072089.

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Book chapters on the topic "Cardiosphere-derived cell"

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Smith, Rachel Ruckdeschel. "Cardiosphere-Derived Cells." In Stem Cell and Gene Therapy for Cardiovascular Disease, 217–22. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-801888-0.00017-5.

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