Dissertations / Theses on the topic 'Cardiopulmonary bypass'
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John, Alison Elizabeth. "Interleukin-8 and cardiopulmonary bypass." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301551.
Full textLinden, Matthew D. "The haemostatic defect of cardiopulmonary bypass." University of Western Australia. School of Surgery and Pathology, 2003. http://theses.library.uwa.edu.au/adt-WU2006.0009.
Full textVassalos, Tony. "End organ effects of paediatric cardiopulmonary bypass." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2385/.
Full textBaig, Kamran. "Effects of complement factor 1 inhibitor on cardiopulmonary function in neonatal cardiopulmonary bypass." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497651.
Full textSvenmarker, Staffan. "Heparin coating and cardiotomy suction in cardiopulmonary bypass." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134.
Full textJones, J. M. "β2 adrenergic receptor gene therapy during cardiopulmonary bypass." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605686.
Full textSalameh, Aida, Stefan Dhein, Ingo Dähnert, and Norbert Klein. "Neuroprotective strategies during cardiac surgery with cardiopulmonary bypass." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215752.
Full textBooker, Peter Driscoll. "Gut mucosal perfusion in infants undergoing hypothermic cardiopulmonary bypass." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250543.
Full textParratt, Rachel Nalini. "Monocyte activation of coagulation by cardiopulmonary bypass CPB circuits." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312851.
Full textPallares, Luiz Carlos Marques. "Oxygen transport in cardiopulmonary bypass induced acute lung injury." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307379.
Full textCollins, J. D. "A study of the liver following cardiopulmonary bypass surgery." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241404.
Full textAllen, M. L. "Monocytes and their role in inflammation following cardiopulmonary bypass." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446565/.
Full textVelissaris, Theodore. "Splanchnic injury during coronary surgery with and without cardiopulmonary bypass." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439379.
Full textNarayan, Pradeep. "Cardiopulmonary bypass against Ischaemic arrest : a prospective randomised study (CAIAS)." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633453.
Full textDeakin, C. D. S. "Analysis of thermal changes in patients during hypothermic cardiopulmonary bypass." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598464.
Full textEvans, Betsy Jane. "Investigation of Leucocyte Trafficking inti Skin Blisters During Cardiopulmonary Bypass." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519603.
Full textFlannery, Fionnula Rose. "Neuropsychological outcomes in older adults after surgery with cardiopulmonary bypass." Thesis, University of Sussex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432425.
Full textKuo, James Hang Ung. "Blood cell trauma and renal pathophysiology associated with cardiopulmonary bypass." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246088.
Full textRice, Cynthia K. "Design of a patient monitoring system for cardiopulmonary bypass surgery." Thesis, Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/50081.
Full textMaster of Science
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Koning, Nick Julius. "Protection of the microcirculation during cardiac surgery with cardiopulmonary bypass." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0073/document.
Full textCardiac surgery with cardiopulmonary bypass leads to impaired perfusion of the microcirculation, which may be an important contributor to postoperative organ dysfunction. This thesis combines clinical and animal studies that aimed to investigate the mechanisms underlying microcirculatory dysfunction in cardiac surgery with cardiopulmonary bypass. Moreover, we aimed to evaluate two treatments strategies for preservation of microcirculatory perfusion during cardiopulmonary bypass : the use of pulsatile flow as compared to the conventional non pulsatile flow during cardiopulmonary bypass and treatment with imatinib in order to reduce vascular leakage by inhibiting endothelial barrier dysfunction.The current thesis has demonstrated that microcirculatory perfusion is impaired during and after cardiac surgery, and this can be attributed mainly to inflammatory endothelial barrier dysfunction and consequent vascular leakage. Concomitant hemodilution may additionally contribute to reduced microvascular perfusion and oxygenation in on-pumpcardiac surgery. We showed that the use of pulsatile flow during cardiopulmonary bypass improves postoperative microvascular perfusion as compared to non pulsatile flow. Imatinib treatment reduced endothelial barrier dysfunction and vascular leakage in our rat model for cardiopulmonary bypass and resulted in preservation of microcirculatory perfusion andoxygenation during and after extracorporeal circulation.Moreover, imatinib treatment resulted in reduced markers ofrenal, pulmonary and intestinal injury after cardiopulmonary bypass. Based on our findings, reduction of vascular leakage and use of pulsatile flow during cardiopulmonary bypass are promising interventions for the prevention of postoperative complications in patients at risk for organ failure following cardiac surgery with cardiopulmonary bypass
Ray, Michael John. "Causes and prevention of excessive bleeding after cardiopulmonary bypass surgery." Thesis, Queensland University of Technology, 1997.
Find full textRajakaruna, Chanaka. "Splanchnic organ function and glucose metabolism during coronary artery bypass surgery with or without cardiopulmonary bypass." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492604.
Full textOfoegbu, Chimu K. P. "Outcomes of "off-pump" coronary artery bypass grafting in a developing country : advantages over coronary artery bypass grafting on cardiopulmonary bypass." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/11432.
Full textIncludes bibliographic references (leaves 53-62).
Off-pump coronary artery bypass grafting (OPCAB) was developed to avoid the deleterious effects of CPB. Current literature reveals some peri-operative advantages of OPCAB, with few studies detailing these in Africa. We review our institutional experience with both approaches in higher risk patients to determine pre-operative characteristics, short and mid-term outcomes in a developing country.
Figueras, Cecile Amanda. "The effects of geometric changes on flow patterns in anastomotic grafts." Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/16751.
Full textMaquelin, Kyra Nicole. "Platelet activation and microparticles in the pericardial cavity during cardiopulmonary bypass." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/70014.
Full textLi, Jia. "Oxygen consumption and oxygen delivery in children after cardiopulmonary bypass surgery." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406548.
Full textTovedal, Thomas. "Cerebral perfusion during cardiopulmonary bypass with special reference to blood flow." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248686.
Full textGourlay, T. "Controlled pulsatile architecture in cardiopulmonary bypass : in-vitro and clinical studies." Thesis, University of Strathclyde, 1997. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21361.
Full textWhitbourne, Peta Gaye. "Changes in the clotting viscoelasticity caused by cardiopulmonary bypass (CPB) surgery." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50547.
Full textIncludes bibliographical references (leaves 63-66).
One to three percent of the Open Heart Surgery procedures have abnormal bleeding due to acquired platelet dysfunction. Standard clotting tests to determine the cause of bleeding usually take between 25 and 60 minutes to get results. This time frame is not useful for deciding what type of treatment to give to a patient. More importantly, the standard clotting tests is they cannot determine platelet function. The Thrombo-Visco Elastogram (TVE) is a new test that provides results in less than 15 minutes and has the potential to evaluate platelet function. In this study, we used the TVE test to assess viscoelasticity of clotting blood from patients before and after CPB. For each patient and condition, we tested the blood alone and after incubation with a saturation concentration of ReoProTM, a glycoprotein Ilb/Illa inhibitor. The major findings of this study are: 1) The TVE device is capable of determining with accuracy quantitative changes in blood viscoelasticity during clotting; 2) The TVE-derived coagulation parameters maximum elastic modulus (Emax), maximum rate of change of elastic modulus (E'max), maximum viscosity ([eta]max), and maximum rate of change of viscosity ([eta]'max) and the coagulation parameters prothrombin time (PT), platelet count, fibrinogen concentration and hematocrit are all affected by CPB; 3) The TVE-derived parameters were all substantially affected by incubation of the blood with the platelet GP inhibitor suggesting that these parameters are exquisitely sensitive to platelet function; and 4) In ReoProTM-free blood samples, values of E'max for all patients, before and after CPB, could be predicted as a function of platelet count, fibrinogen concentration and hematocrit. We concluded that the TVE/ReoProTM assay has the potential to assess the contribution of platelet function and soluble components to coagulation in a quantitative, reproducible and practical manner.
by Peta Gaye Sonya Whitbourne.
S.M.
Wanikiat, Payong. "Inhibition of neutrophil activation : effects in reperfusion injury and cardiopulmonary bypass." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/23245.
Full textRaedschelders, Koen. "A clinical appraisal of propofol-mediated, antioxidant-based cardioprotection during coronary artery bypass grafting with cardiopulmonary bypass." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33736.
Full textTaggart, David Paul. "The effects of a platelet activating factor antagonist on the respiratory, myocardial and cerebral consequences of cardiopulmonary bypass and further observations on cardiac surgery without cardiopulmonary bypass." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248531.
Full textAnnapoorna, Mary. "Cardiopulmonary predicators of dysfunctional ventilator weaning response after coronary artery bypass Graft." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-017-annapoorna-index.html.
Full textTitle from title page screen (viewed on July 18, 2008). Research advisor: Dr. Carol Lynn Thompson, PhD. Document formatted into pages (xiv,151 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 132-144).
Warren, Oliver J. "Defining the role of leukocyte depleting filters within the cardiopulmonary bypass circuit." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506052.
Full textSvoren, E. M. "Genetic regulation of the host response to cardiac surgery and cardiopulmonary bypass." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/31868.
Full textRaymond, Paul Douglas. "Haemostatic activation and its relationship to neuropsychological changes following cardiopulmonary bypass surgery." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16405/1/Paul_Raymond_Thesis.pdf.
Full textRaymond, Paul Douglas. "Haemostatic activation and its relationship to neuropsychological changes following cardiopulmonary bypass surgery." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16405/.
Full textVarghese, David. "Perioperative organ dysfunction in patients undergoing coronary artery bypass grafting either with cardiopulmonary bypass and cardioplegic arrest or without." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/364928/.
Full textRimpiläinen, R. (Riikka). "Minimized cardiopulmonary bypass in extracorporeal circulation:a clinical and experimental comparison with conventional techniques." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294310.
Full textTiivistelmä Sydänkeuhkokoneen käyttö aiheuttaa elimistössä hemodiluution, yleistyneen tulehdusvasteen ja hyytymisjärjestelmän aktivoitumisen sekä mikroembolisaatiota. Ilmiöt ovat yleensä lieviä ja ohimeneviä, mutta voivat johtaa elintoimintahäiriöihin ja pitkittyneeseen toipumiseen sydänleikkauksen jälkeen. Haittojen lievittämiseksi sydänkeuhkokonetta on pyritty kehittämään fysiologisemmaksi. Miniperfuusiolaitteistoissa kiertävän veren kontakti pintamateriaalien ja ilman kanssa jää pienemmäksi ja veren laimenemista tapahtuu vähemmän. Tutkimuksen tavoitteena oli selvittää voidaanko miniperfuusiolla lievittää sydänkeuhkokoneen haittoja. Ensimmäisessä osatyössä selvitettiin miniperfuusion käyttökelpoisuutta ja vaikutusta verensiirtotarpeeseen ohitusleikkauspotilailla valikoimattomassa aineistossa. Toisessa ja kolmannessa osatyössä selvitettiin silmänpohjan mikroembolioiden ilmaantuvuutta miniperfuusion ja perinteisen sydänkeuhkokoneen käytön jälkeen ohitusleikkauspotilailla ja aorttaläppäleikkauspotilailla. Toisessa ja kolmannessa osatyössä selvitettiin lisäksi miniperfuusion vaikutuksia yleistyneen tulehdusvasteen voimakkuuteen, hyytymisjärjestelmään sekä endoteelin aktivaatioon perinteiseen sydänkeuhkokoneeseen verrattuna. Neljännessä osatyössä verrattiin kokeellisessa mallissa miniperfuusion ja perinteisen sydänkeuhkokoneen vaikutuksia suoliston limakalvon eheyteen. Miniperfuusio ilmeni yhtä käyttökelpoiseksi kuin perinteinen sydänkeuhkokone ohitusleikkauspotilaiden hoidossa. Ohitusleikkauspotilailla ilmeni vähemmän silmänpohjan mikroembolioita miniperfuusion jälkeen, mutta aorttaläppäleikkauspotilailla ero ei ollut tilastollisesti merkitsevä. Miniperfuusion käyttöön liittyi vähemmän neutrofiilien aktivaatiota. Tekniikoiden välillä ei ilmennyt eroa hyytymisjärjestelmän eikä endoteelin aktivaatiota osoittavissa merkkiaineissa. Sydänkeuhkokoneen käyttö aiheutti saman tasoisen suoliston limakalvon vaurion miniperfuusiolla ja perinteisellä sydänkeuhkokoneella. Tutkimuksen perusteella miniperfuusiotekniikkaa voidaan käyttää turvallisesti ohitusleikkauspotilaiden hoidossa ja sen käyttö vähentää hemodiluutiota ja neutrofiilien aktivaatiota verrattuna perinteiseen sydänkeuhkokoneeseen. Miniperfuusiolla voidaan vähentää sydänkeuhkokoneen käytön aiheuttamaa silmänpohjan mikroembolisaatiota, joka saattaa viitata vähäisempään aivoverenkierron mikroembolisaatioon. Miniperfuusiotekniikoiden tulee edelleen kehittyä hyödyttämään enemmän myös aorttaläppäleikkauspotilaita. Löydökset koskien sydänkeuhkokoneen aiheuttamia suoliston limakalvovaurioita vahvistavat aiempaa olettamusta suoliston haavoittuvuudesta sydänleikkauksen jälkeen
Hyde, Jonathan A. J. "The effect of flow generation technique during cardiopulmonary bypass on remote organ injury." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268855.
Full textFunamoto, Masaki. "Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass." Kyoto University, 2018. http://hdl.handle.net/2433/232476.
Full textPercy, Charles L. "Predicting excess bleeding due to haemostatic failure following cardiac surgery requiring cardiopulmonary bypass." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/76453/.
Full textHector, Lauren Rachel. "Patient predisposition and the inflammatory response following cardiopulmonary bypass : the role of haemolysis." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9505.
Full textIgreja, S. "The influence of mannose-binding lectin polymorphisms in children undergoing cardiopulmonary bypass surgery." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445938/.
Full textSheppard, Stuart Vincent. "Leucocyte filtration and cardiac surgery." Thesis, University of Portsmouth, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310490.
Full textSolberg, Robert Glen. "Extracorporeal Circulation: Effect of Long-Term (24-Hour) Circulation on Blood Components." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/32157.
Full textMaster of Science
Yogaratnam, Jeysen Zivan. "The effects of preconditioning coronary artery disease patients with hyperbaric oxygen prior to coronary artery bypass graft surgery & cardiopulmonary bypass." Thesis, University of Hull, 2011. http://hydra.hull.ac.uk/resources/hull:4803.
Full textVedin, Jenny. "Coronary artery bypass surgery without extracorporeal circulation /." Stockholm, 2005. http://diss.kib.ki.se/2006/91-7140-507-0/.
Full textEl-Habbal, Magdi Hassan Ali. "Inflammatory changes during cardiopulmonary bypass surgery and their modulation by modified ultrafiltration in children." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285492.
Full textHirao, Shingo. "Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model." Kyoto University, 2018. http://hdl.handle.net/2433/232083.
Full text