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1

Kalinoski, Hannah, Abdel Daoud, Vitali Rusinkevich, et al. "Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis." Proceedings of the National Academy of Sciences of the United States of America 121, no. 42 (2024): art. no. e2323052121. https://doi.org/10.1073/pnas.2323052121.

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Cardiac myosin-specific (MyHC) T cells drive the disease pathogenesis of immune checkpoint inhibitor-associated myocarditis (ICI-myocarditis). To determine whether MyHC T cells are tissue-resident memory T (T(RM)) cells, we characterized cardiac T(RM) cells in naive mice and established that they have a distinct phenotypic and transcriptional profile that can be defined by their upregulation of CD69, PD-1, and CXCR6. We then investigated the effects of cardiac injury through a modified experimental autoimmune myocarditis mouse model and an ischemia-reperfusion injury mouse model and determined
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Ryan, Paul, Caitriona McGrath, Iain Lawrie, Caoimhe Fitzsimons, Jack O’Shea, and Aoife De BrÚn. "Enhancing efficiency in a cardiac investigations department by increasing remote patient monitoring." International Journal for Quality in Health Care 31, Supplement_1 (2019): 29–34. http://dx.doi.org/10.1093/intqhc/mzz065.

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Abstract Objective Remote monitoring (RM) of patients with cardiac rhythm management devices enables healthcare teams to effectively and efficiently monitor patients with heart problems without the requirement in-person patient visits. RM has been associated with safer and higher quality care but was not being used to its full potential in this setting. Cardiac rhythm management had observed an average implant rate of 295 devices per year over the past 13 years, resulting in a five-fold growth in patient follow-up in clinics. This increased demand was becoming unmanageable, with impacts on car
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Ahn, Jeonghoon, Kim Eung Ju, Justin Yoo, Irene Colangelo, Loredana Morichelli, and Renato Pietro Ricci. "OP64 Economic Impact Of Cardiac Device Remote Monitoring In South Korea." International Journal of Technology Assessment in Health Care 33, S1 (2017): 28. http://dx.doi.org/10.1017/s0266462317001477.

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INTRODUCTION:The reduction of healthcare costs and societal cost due to remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) has been demonstrated in several countries; however, to the best of our knowledge it does not exist for South Korea. This work aims at providing an estimation of the potential benefit of RM versus standard care (SC) of CIEDs in term of healthcare costs in South Korea, in order to provide additional substance to the currently ongoing societal debate about the value of telemedicine.METHODS:Healthcare resource consumption was taken from the results of th
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Pluta, Sławomir, Ewa Piotrowicz, Ryszard Piotrowicz, et al. "Remote Monitoring of Cardiac Implantable Electronic Devices in Patients Undergoing Hybrid Comprehensive Telerehabilitation in Comparison to the Usual Care. Subanalysis from Telerehabilitation in Heart Failure Patients (TELEREH-HF) Randomised Clinical Trial." Journal of Clinical Medicine 9, no. 11 (2020): 3729. http://dx.doi.org/10.3390/jcm9113729.

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Background: The impact of cardiac rehabilitation on the number of alerts in patients with remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) is unknown. We compared alerts in RM and outcomes in patients with CIEDs undergoing hybrid comprehensive telerehabilitation (HCTR) versus usual care (UC). Methods: Patients with heart failure (HF) after a hospitalization due to worsening HF within the last 6 months (New York Heart Association (NYHA) class I-III and left ventricular ejection fraction (LVEF) ≤40%) were enrolled in the TELEREH-HF study and randomised 1:1 to HCTR or UC.
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Ricci, Renato Pietro, Loredana Morichelli, and Niraj Varma. "Remote Monitoring for Follow-up of Patients with Cardiac Implantable Electronic Devices." Arrhythmia & Electrophysiology Review 3, no. 2 (2014): 123. http://dx.doi.org/10.15420/aer.2014.3.2.123.

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Follow-up of patients with cardiac implantable electronic devices is challenging due to the increasing number and technical complexity of devices coupled to increasing clinical complexity of patients. Remote monitoring (RM) offers the opportunity to optimise clinic workflow and to improve device monitoring and patient management. Several randomised clinical trials and registries have demonstrated that RM may reduce number of hospital visits, time required for patient follow-up, physician and nurse time, hospital and social costs. Furthermore, patient retention and adherence to follow-up schedu
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McGee, Michael J., Max Ray, Stepehn C. Brienesse, et al. "Remote monitoring in patients with heart failure with cardiac implantable electronic devices: a systematic review and meta-analysis." Open Heart 9, no. 2 (2022): e002096. http://dx.doi.org/10.1136/openhrt-2022-002096.

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BackgroundRemote monitoring (RM) of cardiac implantable electronic devices (CIEDs) is now the standard of care, but whether the demonstrated benefits of RM translate into improvements in heart failure (HF) management is controversial. This systematic review addresses the role of RM in patients with HF with a CIED.Methods and resultsA systematic search of the literature for randomised clinical trials in patients with HF and a CIED assessing efficacy/effectiveness of RM was performed using MEDLINE, PubMed and Embase. Meta-analysis was performed on the effects of RM of CIEDs in patients with HF o
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7

Preda, Alberto, Raffaele Falco, Chiara Tognola, et al. "Contemporary Advances in Cardiac Remote Monitoring: A Comprehensive, Updated Mini-Review." Medicina 60, no. 5 (2024): 819. http://dx.doi.org/10.3390/medicina60050819.

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Over the past decade, remote monitoring (RM) has become an increasingly popular way to improve healthcare and health outcomes. Modern cardiac implantable electronic devices (CIEDs) are capable of recording an increasing amount of data related to CIED function, arrhythmias, physiological status and hemodynamic parameters, providing in-depth and updated information on patient cardiovascular function. The extensive use of RM for patients with CIED allows for early diagnosis and rapid assessment of relevant issues, both clinical and technical, as well as replacing outpatient follow-up improving ov
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8

Kumar, Sharath, Jason Davis, Bernard Thibault, et al. "Canadian Registry of Electronic Device Outcomes: remote monitoring outcomes in the Abbott battery performance alert—a multicentre cohort." EP Europace 23, no. 8 (2021): 1319–23. http://dx.doi.org/10.1093/europace/euab025.

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Abstract Aims Cardiac implantable electronic devices with device advisories have the potential of device malfunction. Remote monitoring (RM) of devices has been suggested to allow the identification of abnormal device performance and permit early intervention. We sought to describe the outcomes of patients with and without RM in devices subject to the Abbott Premature Battery Depletion (PBD) advisory with data from a Canadian registry. Methods and results Patients with an Abbott device subject to the PBD advisory from nine implantable cardioverter defibrillator (ICD) implanting centres in Cana
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9

Maines, Massimiliano, Pietro Palmisano, Maurizio Del Greco, et al. "Impact of COVID-19 Pandemic on Remote Monitoring of Cardiac Implantable Electronic Devices in Italy: Results of a Survey Promoted by AIAC (Italian Association of Arrhythmology and Cardiac Pacing)." Journal of Clinical Medicine 10, no. 18 (2021): 4086. http://dx.doi.org/10.3390/jcm10184086.

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The COVID-19 pandemic has had a profound impact on the organisation of health care in Italy, with an acceleration in the development of telemedicine. To assess the impact of the COVID-19 pandemic on the spread of remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) in Italy, a survey addressed to cardiologists operating in all Italian CIED-implanting centres was launched. A total of 127 cardiologists from 116 Italian arrhythmia centres took part in the survey, 41.0% of all 283 CIED-implanting centres operating in Italy in 2019. All participating centres declared to use RM o
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10

Bolognesi, M., L. Rossi, A. Biagi, et al. "MANAGEMENT OF REMOTE MONITORING FOR IMPLANTABLE DEVICES CONTROLS: SINGLE CENTER EXPERIENCE." European Heart Journal Supplements 26, Supplement_2 (2024): ii104. http://dx.doi.org/10.1093/eurheartjsupp/suae036.257.

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Abstract Background Nowadays the benefits of remote monitoring (RM)of cardiac implantable electronic devices (CIEDs) are Known: an improved both device surveillance and patient clinical management and a decrease in office follow up. So RM is used as supplement in clinic follow up for patients with CIED.However despite decades to RM utilization there are challenges in managing patients with RM including large number of trasmissions and lack of trained staff. There are many different model of care to RM management. Methods We describe our model of care to management CIED recipients with RM consi
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Giannola, Gabriele, Riccardo Torcivia, Riccardo Airò Farulla, and Tommaso Cipolla. "Outsourcing the Remote Management of Cardiac Implantable Electronic Devices: Medical Care Quality Improvement Project." JMIR Cardio 3, no. 2 (2019): e9815. http://dx.doi.org/10.2196/cardio.9815.

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Background Remote management is partially replacing routine follow-up in patients implanted with cardiac implantable electronic devices (CIEDs). Although it reduces clinical staff time compared with standard in-office follow-up, a new definition of roles and responsibilities may be needed to review remote transmissions in an effective, efficient, and timely manner. Whether remote triage may be outsourced to an external remote monitoring center (ERMC) is still unclear. Objective The aim of this health care quality improvement project was to evaluate the feasibility of outsourcing remote triage
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Khalikova, M. A., D. A. Tsaregorodtsev, M. M. Beraya, A. V. Sedov, and S. S. Vasyukov. "Advantages of using a portable cardiac monitor in outpatients with paroxysmal atrial fibrillation." Cardiovascular Therapy and Prevention 21, no. 6 (2022): 3225. http://dx.doi.org/10.15829/1728-8800-2022-3225.

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Aim. To study the advantages of using a portable electrocardiographic (ECG) monitor in outpatients with paroxysmal atrial fibrillation (AF).Material and methods. We examined 88 patients (26 men, 62 women, mean age, 63 [57;68] years) with paroxysmal AF with an average frequency of arrhythmia episodes of 1,0 [0.3;3.75] per month. Forty three (49%) patients were included in the remote monitoring (RM) group using the ECG Dongle monitor, and 45 (51%) patients were included in the conventional monitoring (CM) group. Patients underwent scheduled examinations 2, 6 and 12 months after the start of ther
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13

Ruzycki, Shannon Marie, and Michael Prystajecky. "Point-Counterpoint: Perioperative Cardiac Biomarkers." Canadian Journal of General Internal Medicine 14, no. 4 (2019): e14-e22. http://dx.doi.org/10.22374/cjgim.v14i4.347.

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In the following review article, we present arguments for and against the use of postoperative troponin surveillance and preoperative natriuretic peptide testing. This article covers the evidence that informed the CCS 2016 perioperative guidelines and research published since then. This review is based on the debate held at the Canadian Society of Internal Medicine/American College of Physicians Rocky Mountain Chapter Annual Meeting (CSIM/ACP RM) held in October 2018 in Banff, Alberta.
 
 Resume
 Dans l'article de synthèse qui suit, nous présentons des arguments pour et contre l
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Zoppo, Franco, Antonio Lupo, Giacomo Mugnai, and Francesca Zerbo. "Cardiac implantable electronic device remote monitoring in a large cohort of patients and the need for planning." Future Cardiology 16, no. 5 (2020): 447–56. http://dx.doi.org/10.2217/fca-2019-0039.

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Aim: The remote monitoring (RM) of cardiac implantable electronic devices (CIED) is standard of care. We describe an organizational and projection RM workload model. Methods: At the time of the analysis (2015), 3995 CIED patients were followed-up; 1582 (40.5%) with RM. All RM transmissions (Tx) have been gathered in five event types. Results: We received 10,406 Tx, classified as: 128 (1.2%) red alerts, 141 (1.3%) atrial fibrillation episodes, 1944 (18.6%) yellow alerts, 403 (3.9%) lost Tx (disconnected/noncompliant patients) and 7790 (75.0%) Tx ‘OK' (un-eventful Tx). At the time of 100% of rem
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15

Clark, Alexander M., Bailey J. Sousa, Chantal F. Ski, et al. "Main Mechanisms of Remote Monitoring Programs for Cardiac Rehabilitation and Secondary Prevention." Journal of Cardiopulmonary Rehabilitation and Prevention 43, no. 6 (2023): 412–18. http://dx.doi.org/10.1097/hcr.0000000000000802.

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Purpose: The objective of this report was to identify the main mechanisms of home-based remote monitoring programs for cardiac rehabilitation (RM CR) and examine how these mechanisms vary by context. Methods: This was a systematic review using realist synthesis. To be included, articles had to be published in English between 2010 and November 2020 and contain specific data related to mechanisms of effect of programs. MEDLINE All (1946-) via Ovid, Embase (1974-) via Ovid, APA PsycINFO (1806-), CINAHL via EBSCO, Scopus databases, and gray literature were searched. Results: From 13 747 citations,
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16

Almuti, K., M. AlJaabari, Karen McCutchon, et al. "Implementing a New Remote Monitoring Program in the Developing World – The Cleveland Clinic Abu Dhabi Experience." Series of Cardiology Research 5, no. 1 (2023): 46–55. http://dx.doi.org/10.54178/2768-5985.2023a8.

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Background: Remote monitoring (RM) for cardiac implantable electronic devices (CIED) is a class 1A recommendation by expert consensus. RM incorporation into CIED management allows for early detection of abnormalities, improved patient satisfaction, and enhanced device clinic efficiency. Cleveland Clinic Abu Dhabi (CCAD) established the first RM program in the United Arab Emirates in 2015, with over 1000 patients enrolled. We report patient RM compliance as an indicator of the overall benefit of our service, aiming to encourage the widespread application of RM technology in the Middle East and
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Qian, Shuang, Devran Ugurlu, Elliot Fairweather, et al. "Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization." Nature Cardiovascular Research 4, no. 5 (2025): 624–36. https://doi.org/10.1038/s44161-025-00650-0.

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Abstract Large-cohort imaging and diagnostic studies often assess cardiac function but overlook underlying biological mechanisms. Cardiac digital twins (CDTs) are personalized physics-constrained and physiology-constrained in silico representations, uncovering multi-scale insights tied to these mechanisms. In this study, we constructed 3,461 CDTs from the UK Biobank and another 359 from an ischemic heart disease (IHD) cohort, using cardiac magnetic resonance images and electrocardiograms. We show here that sex-specific differences in QRS duration were fully explained by myocardial anatomy whil
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Kowal, Dagmar, Marek Prech, Agnieszka Katarzyńska-Szymańska, et al. "Smartphone App-Based Remote Monitoring Challenges in Patients with Cardiac Resynchronization Therapy Defibrillators—A Multicenter Study." Journal of Clinical Medicine 13, no. 21 (2024): 6323. http://dx.doi.org/10.3390/jcm13216323.

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Background/Objectives: Remote monitoring (RM) cardiac implantable electronic devices for adults delivers improved patient outcomes. However, previously used bedside transmitters are not optimal due to deficient patient adherence. The goal of this study was to evaluate the efficacy of RM regarding the connectivity of smartphone app-based solutions, adherence to scheduled automatic follow-ups, and prevalence of alert-based events. Methods: We evaluated the adult heart failure (HF) population with an implanted cardiac resynchronization therapy defibrillator (CRT-D) divided into two arms: with app
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Swami, Vimarsha, and Lorraine E. Chalifour. "Bisphenol A impacts cardiomyocyte differentiation in vitro by modulating cardiac protein expression." McGill Science Undergraduate Research Journal 5, no. 1 (2010): 42–48. http://dx.doi.org/10.26443/msurj.v5i1.83.

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introduction: Bisphenol A (BPA) is an environmental toxin commonly found in plastics and is able to mimic the actions of endogenous steroid hormones. BPA binds and activates intracellular estrogen receptors (eRα and eRβ) and estrogen related receptor γ (eRRγ), all of which are present in cardiomyocytes. however, it is unclear how BPA impacts the heart. We hypothesized that BPA modulates the expression of proteins regulating cardiac structure, energy and calcium homeostasis during cardiomyocyte differentiation in vitro. Methods: We differentiated h9C2 cells into cardiomyocytes in hormone-replet
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Benvenuto, Simone, Gabriele Simonini, Sara Della Paolera, et al. "Ruolo della RM cardiaca nel follow-up a lungo termine della MIS-C." Medico e Bambino Pagine elettroniche 25, no. 5 (2022): 110–11. http://dx.doi.org/10.53126/mebxxvmg110.

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In this retrospective multicentre study based on cardiac MR, the cardiological outcome of MIS-C patients does appear favourable regardless of severity of the cardiac involvement during the acute phase.
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Nichols, E. H., and S. Mittal. "RM of Implantable Cardiac Devices is Associated with Improved Survival." MD Conference Express 14, no. 9 (2014): 16–17. http://dx.doi.org/10.1177/155989771409007.

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Leary, S. C., C. N. Lyons, A. G. Rosenberger, J. S. Ballantyne, J. Stillman, and C. D. Moyes. "Fiber-type differences in muscle mitochondrial profiles." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 285, no. 4 (2003): R817—R826. http://dx.doi.org/10.1152/ajpregu.00058.2003.

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Although striated muscles differ in mitochondrial content, the extent of fiber-type specific mitochondrial specializations is not well known. To address this issue, we compared mitochondrial structural and functional properties in red muscle (RM), white muscle (WM), and cardiac muscle of rainbow trout. Overall preservation of the basic relationships between oxidative phosphorylation complexes among fiber types was confirmed by kinetic analyses, immunoblotting of native holoproteins, and spectroscopic measurements of cytochrome content. Fiber-type differences in mitochondrial properties were ap
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Hayes, LH, SB Neuhaus, S. Donkervoort, et al. "Taking on the Titin: Muscle imaging as a diagnostic marker of biallelic TTN-related myopathy." Journal of Neuromuscular Diseases 11, no. 6 (2024): 1211–20. https://doi.org/10.1177/22143602241283391.

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Background: The accurate diagnosis of titin-related myopathies ( TTN-RM) is challenging due to the “gigantism” of the coding gene TTN with an incompletely understood landscape of normal genetic variation, an increasing number of pathogenic variants, and wide phenotypic variability of both cardiac and muscle involvement. Particularly in situations of potentially incomplete genotypes, clinicians need more phenotyping tools to help confidently determine the pathogenicity of variants in TTN and accurately diagnose titinopathies. Objective: To illustrate the pattern of muscle involvement found by m
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Ágoston, Márta, Zsófia Kohajda, László Virág, et al. "A Comparative Study of the Rapid (IKr) and Slow (IKs) Delayed Rectifier Potassium Currents in Undiseased Human, Dog, Rabbit, and Guinea Pig Cardiac Ventricular Preparations." Pharmaceuticals 17, no. 8 (2024): 1091. http://dx.doi.org/10.3390/ph17081091.

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To understand the large inter-species variations in drug effects on repolarization, the properties of the rapid (IKr) and the slow (IKs) components of the delayed rectifier potassium currents were compared in myocytes isolated from undiseased human donor (HM), dog (DM), rabbit (RM) and guinea pig (GM) ventricles by applying the patch clamp and conventional microelectrode techniques at 37 °C. The amplitude of the E-4031-sensitive IKr tail current measured at −40 mV after a 1 s long test pulse of 20 mV, which was very similar in HM and DM but significant larger in RM and GM. The L-735,821-sensit
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Bencardino, Gianluigi, Alessandro Telesca, Gianluca Comerci, and Francesco Burzotta. "Acute myocardial infarction revealed by recurrent ventricular tachyarrhythmias detected by remote monitoring." BMJ Case Reports 17, no. 3 (2024): e259951. http://dx.doi.org/10.1136/bcr-2024-259951.

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Remote monitoring (RM) of cardiac implantable electronic devices (CIED) represented a major improvement in clinical practice and has been used with multiple indications. Many parameters monitored on a daily basis by current CIED can indeed assist in clinical practice (eg, decompensated heart failure) by providing the patient with optimal timing for anticipated outpatient visit or urgent medical care. Recognition of acute myocardial infarction (AMI) is not usually considered among the capabilities of RM. We present the case of an AMI occurring without any ischaemic symptoms but associated with
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Nagy, Bettina, Ádám Pál-Jakab, Boldizsár Kiss, et al. "Remote Management of Patients with Cardiac Implantable Electronic Devices during the COVID-19 Pandemic." Journal of Cardiovascular Development and Disease 10, no. 5 (2023): 214. http://dx.doi.org/10.3390/jcdd10050214.

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Remote monitoring (RM) is the newest function of cardiac implantable electronic devices (CIEDs). In our observational retrospective analysis, we aimed to assess whether telecardiology could be a safe alternative to routine outpatient examinations during the COVID-19 pandemic. The in- and outpatient visits, the number of acute cardiac decompensation episodes, the RM data from CIEDs, and general condition were examined via questionnaires (KCCQ, EQ-5D-5L). Regarding the enrolled 85 patients, the number of personal patient appearances was significantly lower in the year following the pandemic outb
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Feigl, Eric O. "Berne's adenosine hypothesis of coronary blood flow control." American Journal of Physiology-Heart and Circulatory Physiology 287, no. 5 (2004): H1891—H1894. http://dx.doi.org/10.1152/classicessays.00003.2004.

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This essay looks at the historical significance of an APS classic paper that is freely available online: Berne RM. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204: 317–322, 1963 ( http://ajplegacy.physiology.org/cgi/reprint/204/2/317 ).
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Kratka, Allison, Thomas L. Rotering, Scott Munson, Merritt H. Raitt, Mary A. Whooley, and Sanket S Dhruva. "Patient and Clinician Perspectives on Alert-Based Remote Monitoring–First Care for Cardiovascular Implantable Electronic Devices: Semistructured Interview Study Within the Veterans Health Administration." JMIR Cardio 9 (April 4, 2025): e66215-e66215. https://doi.org/10.2196/66215.

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Abstract Background Patients with cardiovascular implantable electronic devices (CIEDs) typically attend in-person CIED clinic visits at least annually, paired with remote monitoring (RM). As the CIED data available through in-person CIED clinic visits and RM are nearly identical, the 2023 Heart Rhythm Society expert consensus statement introduced “alert-based RM,” an RM-first approach where patients with CIEDs that are consistently and continuously connected to RM, in the absence of recent alerts and other cardiac comorbidities, could attend in-person CIED clinic visits every 24 months or ult
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Schwab, Joerg O., Herbert Nägele, Hanno Oswald, et al. "Clinical Course of Dual-Chamber Implantable Cardioverter-Defibrillator Recipients followed by Cardiac Remote Monitoring: Insights from the LION Registry." BioMed Research International 2018 (November 4, 2018): 1–8. http://dx.doi.org/10.1155/2018/3120480.

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Patients receiving dual-chamber implantable cardioverter-defibrillator (DR-ICD) therapy are at risk of developing atrial arrhythmia because of the increased rate of ventricular pacing and the progression of heart failure. Remote monitoring (RM) may identify the patients at highest risk of adverse events such as atrial arrhythmias. A total of 283 patients with 91,632 remote transmissions during a 15-month follow-up (FU) period enrolled in the LION registry were analysed. The parameters retrieved included the pacing mode, lower rate limit, percentage of atrial (%AP) and ventricular pacing (%VP),
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Russo, Vincenzo, Antonio Rapacciuolo, Pia Clara Pafundi, et al. "Cardiac implantable electronic devices replacements in patients followed by remote monitoring during COVID-19 lockdown." European Heart Journal - Digital Health 2, no. 1 (2021): 171–74. http://dx.doi.org/10.1093/ehjdh/ztaa018.

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Abstract Aims Following coronavirus disease (COVID-19) outbreak, the Italian government adopted strict rules of lockdown and social distancing. The aim of our study was to assess the admission rate for cardiac implantable electronic devices (CIEDs) replacement procedures in Campania, the 3rd-most-populous region of Italy, during COVID-19 lockdown. Methods and results Data were sourced from 16 referral hospitals in Campania from 10 March to 4 May 2020 (lockdown period) and during the same period in 2019. We retrospectively evaluated consecutive patients hospitalized for CIEDs replacement proced
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Bonamini, M., M. Gallucci, L. Simonetti, et al. "Idrocefalo normoteso: Valutazione comparativa tra studi di dinamica liquorale mediante TC e RM." Rivista di Neuroradiologia 10, no. 2_suppl (1997): 196–98. http://dx.doi.org/10.1177/19714009970100s288.

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Aim of this study was to evaluate the sensitivity of MR dynamic Bolus Tracking technique versus CT-cysterno graphy in Normal Pressure Hydrocephalus (NPH). Seven patients (age 64–76 yrs), clinically suspected of NPH, were retrospectively evaluated. They had been submitted to CT-cysternography, MR dynamic Bolus Tracking technique in the acqueduct (cardiac-gated flow direction evaluation by means of 12–16 FFE T2*-w acquisitions per cardiac cycle, on sagittal plane along the acqueduct, with presaturation perpendicular to the acqueduct) and finally to surgical evaluation and subsequent ventriculo-p
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Moreno Tarazona, Alejandra, Lola Xiomara Bautista, and Fabio Martínez. "Discriminación de enfermedades cardiacas utilizando patrones cinemáticos codificados con convoluciones 3D en secuencias de cine-RM." Biomédica 44, Sp. 1 (2024): 89–100. http://dx.doi.org/10.7705/biomedica.7115.

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Introduction. Cine-MRI (cine-magnetic resonance imaging) sequences are a key diagnostic tool to visualize anatomical information, allowing experts to localize and determine suspicious pathologies. Nonetheless, such analysis remains subjective and prone to diagnosis errors.Objective. To develop a binary and multi-class classification considering various cardiac conditions using a spatiotemporal model that highlights kinematic movements to characterize each disease.Materials and methods. This research focuses on a 3D convolutional representation to characterize cardiac kinematic patterns during
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Kambic, Tim, Nejc Šarabon, Vedran Hadžić, and Mitja Lainscak. "High-Load and Low-Load Resistance Exercise in Patients with Coronary Artery Disease: Feasibility and Safety of a Randomized Controlled Clinical Trial." Journal of Clinical Medicine 11, no. 13 (2022): 3567. http://dx.doi.org/10.3390/jcm11133567.

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Resistance exercise (RE) remains underused in cardiac rehabilitation; therefore, there is insufficient evidence on safety, feasibility, and hemodynamic adaptations to high-load (HL) and low-load (LL) RE in patients with coronary artery disease (CAD). This study aimed to compare the safety, feasibility of HL-RE and LL-RE when combined with aerobic exercise (AE), and hemodynamic adaptations to HL and LL resistance exercise following the intervention. Seventy-nine patients with CAD were randomized either to HL-RE (70–80% of one-repetition maximum [1-RM]) and AE, LL-RE (35–40% of 1-RM) and AE or s
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Jadhav, Ashok, and Joseph Fomusi Ndisang. "Heme Arginate Suppresses Cardiac Lesions and Hypertrophy in Deoxycorticosterone Acetate-Salt Hypertension." Experimental Biology and Medicine 234, no. 7 (2009): 764–78. http://dx.doi.org/10.3181/0810-rm-302.

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Gobbo, Helyel Rodrigues, Gabriel Marcelino Barbosa, Lucas Cezar de Oliveira, and Gustavo Vieira de Oliveira. "The Effect of Different Resistance Training Protocols on Cardiac Autonomic Modulation During Exercise Recovery: A Crossover, Randomized, and Controlled Pilot Study." Journal of Vascular Diseases 3, no. 4 (2024): 375–84. http://dx.doi.org/10.3390/jvd3040029.

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Purpose: This study investigated the impact of two different resistance training (RT) protocols on cardiac autonomic modulation during exercise recovery in trained individuals. It was hypothesized that a hypertrophic resistance training program would induce more significant stress and negatively affect cardiac autonomic modulation compared to a power/force resistance training program. Methods: Six healthy, trained participants (aged 18–40) were randomized in a crossover and controlled pilot study. Participants performed two RT protocols: (i) three sets of 10 repetitions with 85% of 10 RM, 60 s
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Kumar, Srinivasan Dinesh, Sook-Kwin Yong, S. Thameem Dheen, Boon-Huat Bay, and Samuel Sam-Wah Tay. "Cardiac Malformations Are Associated with Altered Expression of Vascular Endothelial Growth Factor and Endothelial Nitric Oxide Synthase Genes in Embryos of Diabetic Mice." Experimental Biology and Medicine 233, no. 11 (2008): 1421–32. http://dx.doi.org/10.3181/0806-rm-186.

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The aim of this study was to investigate the role of nitric oxide (NO), and the expression of endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) genes in developing hearts at embryonic day 13.5 of embryos from diabetic mice. The protein and mRNA expression levels of eNOS and VEGF were significantly altered in the developing hearts of embryos from diabetic mice. The NO level was significantly decreased, whereas the VEGF concentration was significantly increased in the developing hearts of the embryos from diabetic mice. In vitro study showed a significant red
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Mason, Peggy, Keming Gao, and Jonathan R. Genzen. "Serotonergic Raphe Magnus Cell Discharge Reflects Ongoing Autonomic and Respiratory Activities." Journal of Neurophysiology 98, no. 4 (2007): 1919–27. http://dx.doi.org/10.1152/jn.00813.2007.

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Serotonergic cells are located in a restricted number of brain stem nuclei, send projections to virtually all parts of the CNS, and are critical to normal brain function. They discharge tonically at a rate modulated by the sleep–wake cycle and, in the case of medullary serotonergic cells in raphe magnus and the adjacent reticular formation (RM), are excited by cold challenge. Yet, beyond behavioral state and cold, endogenous factors that influence serotonergic cell discharge remain largely mysterious. The present study in the anesthetized rat investigated predictors of serotonergic RM cell dis
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Choi, Hyun Ju, Mi Ra Seon, Soon Sung Lim, Jong-Sang Kim, Hyang Sook Chun, and Jung Han Yoon Park. "Hexane/Ethanol Extract ofGlycyrrhiza uralensisLicorice Suppresses Doxorubicin-Induced Apoptosis in H9c2 Rat Cardiac Myoblasts." Experimental Biology and Medicine 233, no. 12 (2008): 1554–60. http://dx.doi.org/10.3181/0807-rm-221.

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Holcomb, Mark R., Marcella C. Woods, Ilija Uzelac, John P. Wikswo, Jonathan M. Gilligan, and Veniamin Y. Sidorov. "The Potential of Dual Camera Systems for Multimodal Imaging of Cardiac Electrophysiology and Metabolism." Experimental Biology and Medicine 234, no. 11 (2009): 1355–73. http://dx.doi.org/10.3181/0902-rm-47.

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Barreto Bittencourt, Joana, Adna Keyne, and Jorge Andion Torreão. "Fatores Associados à Ressonância Magnética Cardíaca (RMC) em Acidente Vascular Cerebral Isquêmico (AVCI) de Causa Indeterminada." Revista Científica Hospital Santa Izabel 3, no. 2 (2020): 119–20. http://dx.doi.org/10.35753/rchsi.v3i2.28.

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Resumo do Artigo: Neri LR, Torreão JA, Porto LM, Gonçalves BMM, Andrade ALA, Pereira CB, Garcia KO, Catto MB, Muinos PJR, Maia RM, Silva TC, Jesus PAP, Rocha-Filho JA, Oliveira-Filho Factors associated with abnormal cardiac magnetic resonance imaging in embolic stroke of undetermined source. JInternational Journal of Stroke. First Published March 29, 2019 Letter. https://doi.org/10.1177/1747493019840928
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Borghi-Silva, Audrey, Cláudia Carrascosa, Cristino Carneiro Oliveira, et al. "Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 6 (2008): H2465—H2472. http://dx.doi.org/10.1152/ajpheart.91520.2007.

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Blood flow requirements of the respiratory muscles (RM) increase markedly during exercise in chronic heart failure (CHF). We reasoned that if the RM could subtract a fraction of the limited cardiac output (QT) from the peripheral muscles, RM unloading would improve locomotor muscle perfusion. Nine patients with CHF (left ventricle ejection fraction = 26 ± 7%) undertook constant-work rate tests (70-80% peak) receiving proportional assisted ventilation (PAV) or sham ventilation. Relative changes (Δ%) in deoxy-hemoglobyn, oxi-Hb ([O2Hb]), tissue oxygenation index, and total Hb ([HbTOT], an index
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Saporito, D., F. Fabbri, L. Spighi, N. Trevisi, and F. Ottani. "MAGNETIC RESONANCE AND CARDIAC IMPLANTABLE DEVICES: A SAFE COMBINATION." European Heart Journal Supplements 26, Supplement_2 (2024): ii18. http://dx.doi.org/10.1093/eurheartjsupp/suae036.037.

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Abstract Despite guidelines the presence of a cardiac implantable device (CIED) in a magnetic resonance (MR) ambient raises fears and perplexities and generates the often inappropriate request for support from the electrophysiologist. From January 2019 to November 2023 all patients with a cardiac implantable device (CIED) undergoing magnetic resonance (MR) were evaluated. All CIEDS were classified into three subgroups: MR–conditional, MR–unsafe and "non MR–conditional" (catheters and generators MR–conditional but of different manufacturers). No implantable loop recorders were enrolled. We perf
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Kalinoski, Hannah, Abdel Daoud, Vitali Rusinkevich, et al. "Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis." Proceedings of the National Academy of Sciences 121, no. 42 (2024). http://dx.doi.org/10.1073/pnas.2323052121.

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Cardiac myosin-specific (MyHC) T cells drive the disease pathogenesis of immune checkpoint inhibitor–associated myocarditis (ICI-myocarditis). To determine whether MyHC T cells are tissue-resident memory T (T RM ) cells, we characterized cardiac T RM cells in naive mice and established that they have a distinct phenotypic and transcriptional profile that can be defined by their upregulation of CD69, PD-1, and CXCR6. We then investigated the effects of cardiac injury through a modified experimental autoimmune myocarditis mouse model and an ischemia–reperfusion injury mouse model and determined
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Veres, B., B. Kiss, P. Fehervari, et al. "Enhancing heart failure management: a comprehensive analysis of continuous remote monitoring vs. standard care in patients with cardiac implantable electronic devices." Europace 26, Supplement_1 (2024). http://dx.doi.org/10.1093/europace/euae102.501.

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Abstract Background Utilizing remote monitoring (RM) in patients with heart failure (HF) who have cardiac implantable electronic devices (CIED) proves to be a dependable method for closely adhering to device-specific and heart failure-related parameters. While there is some favorable outcome data, the results remain incomplete. Aims We aimed to evaluate the advantages of continuous RM compared to the standard of care (SoC) in reducing all-cause mortality, cardiovascular-related death (CV), sudden cardiac death, and ICD shocks. Methods A systematic review and meta-analysis of randomized control
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Lehmann, H. Immo, Krishan Sharma, Roma Bhatia, et al. "Real‐World Disparities in Remote Follow‐Up of Cardiac Implantable Electronic Devices and Impact of the COVID‐19 Pandemic: A Single‐Center Experience." Journal of the American Heart Association, January 23, 2023. http://dx.doi.org/10.1161/jaha.122.027500.

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Background Remote monitoring (RM) of cardiac implantable electronic devices has been shown to improve cardiovascular morbidity and mortality. To date, no studies have investigated disparities in use and delivery of RM. This study was performed to investigate if racial and socioeconomic disparities are present in cardiac implantable electronic device RM. Methods and Results This was a retrospective observational cohort study at a single tertiary care center in the United States. Patients who received a newly implanted cardiac implantable electronic device or device upgrade between January 2017
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Manyam, Harish, Haran Burri, Ruben Casado-Arroyo, et al. "SMARTPHONE-BASED CIED REMOTE MONITORING: IMPROVED COMPLIANCE AND CONNECTIVITY." European Heart Journal - Digital Health, November 11, 2022. http://dx.doi.org/10.1093/ehjdh/ztac071.

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Abstract Objective Remote monitoring (RM) is the standard of care for follow up of patients with cardiac implantable electronic devices. The aim of this study was to compare smartphone-based RM (SM-RM) using patient applications (myMerlinPulseTM app) with traditional bedside monitor RM (BM-RM). Methods The retrospective study included de-identified U.S. patients who received either SM-RM or BM-RM capable implantable cardioverter defibrillators or cardiac resynchronization therapy defibrillators (Abbott, USA). Patients in SM-RM and BM-RM groups were propensity-score matched on age and gender, d
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Tan, Vern Hsen, Hui Xin See Tow, Khi Yung Fong, et al. "Remote monitoring of cardiac implantable electronic devices using smart device interface versus radiofrequency‐based interface: A systematic review." Journal of Arrhythmia, May 9, 2024. http://dx.doi.org/10.1002/joa3.13054.

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AbstractBackgroundGuidelines recommended remote monitoring (RM) in managing patients with Cardiac Implantable Electronic Devices. In recent years, smart device (phone or tablet) monitoring‐based RM (SM‐RM) was introduced. This study aims to systematically review SM‐RM versus bedside monitor RM (BM‐RM) using radiofrequency in terms of compliance, connectivity, and episode transmission time.MethodsWe conducted a systematic review, searching three international databases from inception until July 2023 for studies comparing SM‐RM (intervention group) versus BM‐RM (control group).ResultsTwo matched
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See Tow, H., K. Y. Fong, Y. Wang, et al. "Remote monitoring of cardiac implantable electronic devices using smart device interface versus radiofrequency-based interface: a systematic review." European Heart Journal 45, Supplement_1 (2024). http://dx.doi.org/10.1093/eurheartj/ehae666.415.

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Abstract Background Guidelines recommended remote monitoring (RM) in managing patients with Cardiac Implantable Electronic Devices (CIED). In recent years, smart device (phone or tablet) monitoring-based RM (SM-RM) was introduced. SM-RM is a specifically developed application (app) which can be downloaded from app stores using smart devices. The app uses Bluetooth low-energy to communicate automatically and securely with the patient’s CIED. The app then uses a cellular or Wi-Fi internet connection to transfer the data securely to the manufacturer’s repository. Purpose This study aims to system
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Ahmad, Shumaila, Sam Straw, John Gierula, et al. "Optimising remote monitoring for cardiac implantable electronic devices: a UK Delphi consensus." Heart, September 18, 2024, heartjnl—2024–324167. http://dx.doi.org/10.1136/heartjnl-2024-324167.

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BackgroundRemote monitoring (RM) is recommended for the ongoing management of patients with cardiac implantable electronic devices (CIEDs). Despite its benefits, RM adoption has increased the workload for cardiac rhythm management teams. This study used a modified Delphi method to develop a consensus on optimal RM management for adult patients with a CIED in the UK.MethodsA national steering committee comprising cardiac physiologists, cardiologists, specialist nurses, support professionals and a patient representative developed 114 statements on best RM practices, covering capacity, support, s
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Seo, Jiyoung, Majd Al Deen Alhuarrat, Suraj Krishnan, et al. "Utilization of the remote monitoring of cardiac implantable electronic devices in a diverse demographic cohort: Insights from a single‐center observation." Pacing and Clinical Electrophysiology, November 27, 2023. http://dx.doi.org/10.1111/pace.14883.

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AbstractBackgroundDespite its clinical benefits, patient compliance to remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) varies and remains under‐studied in diverse populations.ObjectiveWe sought to evaluate RM compliance, clinical outcomes, and identify demographic and socioeconomic factors affecting RM in a diverse urban population in New York.MethodsThis retrospective cohort study included patients enrolled in CIED RM at Montefiore Medical Center between December 2017 and May 2022. RM compliance was defined as the percentage of days compliant to RM transmission divide
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