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Journal articles on the topic 'Carbonic nanoparticles'

Author: Grafiati

Published: 1 February 2025

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1

Demchenko, Alexander. "Excitons in Carbonic Nanostructures." C — Journal of Carbon Research 5, no. 4 (November 12, 2019): 71. http://dx.doi.org/10.3390/c5040071.

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Unexpectedly bright photoluminescence emission can be observed in materials incorporating inorganic carbon when their size is reduced from macro–micro to nano. At present, there is no consensus in its understanding, and many suggested explanations are not consistent with the broad range of experimental data. In this Review, I discuss the possible role of collective excitations (excitons) generated by resonance electronic interactions among the chromophore elements within these nanoparticles. The Förster-type resonance energy transfer (FRET) mechanism of energy migration within nanoparticles operates when the composing fluorophores are the localized electronic systems interacting at a distance. Meanwhile, the resonance interactions among closely located fluorophores may lead to delocalization of the excited states over many molecules resulting in Frenkel excitons. The H-aggregate-type quantum coherence originating from strong coupling among the transition dipoles of adjacent chromophores in a co-facial stacking arrangement and exciton transport to emissive traps are the basis of the presented model. It can explain most of the hitherto known experimental observations and must stimulate the progress towards their versatile applications.

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Lizoňová, Denisa, Monika Majerská, Vlastimil Král, Michal Pechar, Robert Pola, Marek Kovář, and František Štěpánek. "Antibody-pHPMA functionalised fluorescent silica nanoparticles for colorectal carcinoma targeting." RSC Advances 8, no. 39 (2018): 21679–89. http://dx.doi.org/10.1039/c8ra03487g.

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Clark, Andrew J., Devin T. Wiley, Jonathan E. Zuckerman, Paul Webster, Joseph Chao, James Lin, Yun Yen, and Mark E. Davis. "CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing." Proceedings of the National Academy of Sciences 113, no. 14 (March 21, 2016): 3850–54. http://dx.doi.org/10.1073/pnas.1603018113.

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Nanoparticle-based therapeutics are being used to treat patients with solid tumors. Whereas nanoparticles have been shown to preferentially accumulate in solid tumors of animal models, there is little evidence to prove that intact nanoparticles localize to solid tumors of humans when systemically administered. Here, tumor and adjacent, nonneoplastic tissue biopsies are obtained through endoscopic capture from patients with gastric, gastroesophageal, or esophageal cancer who are administered the nanoparticle CRLX101. Both the pre- and postdosing tissue samples adjacent to tumors show no definitive evidence of either the nanoparticle or its drug payload (camptothecin, CPT) contained within the nanoparticle. Similar results are obtained from the predosing tumor samples. However, in nine of nine patients that were evaluated, CPT is detected in the tumor tissue collected 24–48 h after CRLX101 administration. For five of these patients, evidence of the intact deposition of CRLX101 nanoparticles in the tumor tissue is obtained. Indications of CPT pharmacodynamics from tumor biomarkers such as carbonic anhydrase IX and topoisomerase I by immunohistochemistry show clear evidence of biological activity from the delivered CPT in the posttreatment tumors.

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Mikolajczak, Dorian J., and Beate Koksch. "Peptide–Gold Nanoparticle Conjugates as Artificial Carbonic Anhydrase Mimics." Catalysts 9, no. 11 (October 29, 2019): 903. http://dx.doi.org/10.3390/catal9110903.

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We herein describe the design and synthesis of a catalytically active peptide–gold nanoparticle conjugate (Pep-Au-NP) that binds Zn(II) within its peptide monolayer and develops carbonic anhydrase activity. Specifically, a modified variant of the β-sheet forming IHIHIQI-peptide (IHQ), which forms an interstrand 3-His Zn(II)-binding site, was used as a ligand for spherical gold nanoparticles (Au-NPs). The resulting immobilized peptide maintains its ability to form β-sheets, as determined by circular dichroism (CD)-spectroscopy and, thus, maintains its ability to form Zn(II)-binding sites. The addition of Zn(II)-ions to the peptide–gold nanoparticle conjugates (Au@IHQ-NP) resulted in significant improvements in rates of ester hydrolysis of 4-nitrophenyl acetate (4-NPA) and the hydration of CO2 compared to the unconjugated peptide variants. Recycling of the catalyst revealed that Au@IHQ-NP remains intact with at least 94% of its initial activity after five rounds of CO2 hydration. The herein reported results reveal that Pep-Au-NPs are able to perform reactions catalyzed by natural metalloenzymes and open up new possibilities for the implementation of these conjugates.

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Gößl, Dorothée, Helena Singer, Hsin-Yi Chiu, Alexandra Schmidt, Martina Lichtnecker, Hanna Engelke, and Thomas Bein. "Highly active enzymes immobilized in large pore colloidal mesoporous silica nanoparticles." New Journal of Chemistry 43, no. 4 (2019): 1671–80. http://dx.doi.org/10.1039/c8nj04585b.

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6

Alhumaydhi, Fahad A. "Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities." Journal of Nanomaterials 2022 (June 30, 2022): 1–11. http://dx.doi.org/10.1155/2022/5544475.

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The synthesis of metal nanoparticles by using plant extracts is previously explored in phytomedicines. Nanobiotechnology has many applications, including cosmetic, packing, coating, biomedicine, and enhanced biological activity. Keeping in view the importance of Pistacia chinensis, its gold nanoparticles (AuNPs) have been synthesized by the eco-friendless and cost-effective method. In this study, the synthesized nanoparticles were characterized by advanced techniques such as UV-visible spectroscopy, Fourier transform infrared (FT-IR), and atomic force microscope (AFM) analysis. The biological activities of these synthesized nanoparticles were examined in vitro by measuring the enzymatic inhibition potential on urease and carbonic anhydrase and in vivo by determining the analgesic and sedative activities. The UV spectrum indicated various peaks at the range of 530-550 nm, showing nanoparticles formation. The FT-IR spectroscopy of the extracts and AuNPs indicated the presence of NH, C═N, and N═O in the extract involved in the nanoparticles synthesis. The size of nanoparticles was determined by AFM analysis. The AFM showed that the nanoparticles range from 10 to 100 nm and are almost spherical in shape. The synthesized AuNPs exhibited significant urease inhibition potential with an IC50 value of 44.98. Similarly, the nanoparticles exhibited good carbonic anhydrase inhibition with an IC50 value of 53.54 against acetazolamide having IC50 0.13. Pistacia chinensis extract and its AuNPs exhibited excellent attenuation p < 0.01 in acetic acid-induced writhing model at a dose of 15 mg/kg. The synthesized nanoparticles showed a significant sedative effect p < 0.001 compared to the standard drug. This research work has developed a green method to synthesize nanoparticles by using Pistacia chinensis extract and directed the researcher to purify active phytochemicals from Pistacia chinensis involved in nanoparticles synthesized.

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7

Vinoba, Mari, Margandan Bhagiyalakshmi, Soon Kwan Jeong, Sung Chan Nam, and Yeoil Yoon. "Carbonic Anhydrase Immobilized on Encapsulated Magnetic Nanoparticles for CO2Sequestration." Chemistry - A European Journal 18, no. 38 (August 9, 2012): 12028–34. http://dx.doi.org/10.1002/chem.201201112.

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8

Cabaleiro-Lago, Celia, and Martin Lundqvist. "The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II." Molecules 25, no. 19 (September 25, 2020): 4405. http://dx.doi.org/10.3390/molecules25194405.

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Human carbonic anhydrases (hCAs) belong to a well characterized group of metalloenzymes that catalyze the conversion of carbonic dioxide into bicarbonate. There are currently 15 known human isoforms of carbonic anhydrase with different functions and distribution in the body. This links to the relevance of hCA variants to several diseases such as glaucoma, epilepsy, mountain sickness, ulcers, osteoporosis, obesity and cancer. This review will focus on two of the human isoforms, hCA I and hCA II. Both are cytosolic enzymes with similar topology and 60% sequence homology but different catalytic efficiency and stability. Proteins in general adsorb on surfaces and this is also the case for hCA I and hCA II. The adsorption process can lead to alteration of the original function of the protein. However, if the function is preserved interesting biotechnological applications can be developed. This review will cover the knowledge about the interaction between hCAs and nanomaterials. We will highlight how the interaction may lead to conformational changes that render the enzyme inactive. Moreover, the importance of different factors on the final effect on hCAs, such as protein stability, protein hydrophobic or charged patches and chemistry of the nanoparticle surface will be discussed.

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Bugárová, Nikola, Zdenko Špitálsky, Matej Mičušík, Michal Bodík, Peter Šiffalovič, Martina Koneracká, Vlasta Závišová, et al. "A Multifunctional Graphene Oxide Platform for Targeting Cancer." Cancers 11, no. 6 (May 29, 2019): 753. http://dx.doi.org/10.3390/cancers11060753.

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Diagnosis of oncological diseases remains at the forefront of current medical research. Carbonic Anhydrase IX (CA IX) is a cell surface hypoxia-inducible enzyme functionally involved in adaptation to acidosis that is expressed in aggressive tumors; hence, it can be used as a tumor biomarker. Herein, we propose a nanoscale graphene oxide (GO) platform functionalized with magnetic nanoparticles and a monoclonal antibody specific to the CA IX marker. The GO platforms were prepared by a modified Hummers and Offeman method from exfoliated graphite after several centrifugation and ultrasonication cycles. The magnetic nanoparticles were prepared by a chemical precipitation method and subsequently modified. Basic characterization of GO, such as the degree of oxidation, nanoparticle size and exfoliation, were determined by physical and chemical analysis, including X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDX), and atomic force microscopy (AFM). In addition, the size and properties of the poly-L-lysine-modified magnetic nanoparticles were characterized. The antibody specific to CA IX was linked via an amidic bond to the poly-L-lysine modified magnetic nanoparticles, which were conjugated to GO platform again via an amidic bond. The prepared GO-based platform with magnetic nanoparticles combined with a biosensing antibody element was used for a hypoxic cancer cell targeting study based on immunofluorescence.

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Duart, Marcelo Adriano, Oscar Endrigo Dorneles Rodrigues, and Sérgio Roberto Mortari. "Carbonic nanoparticles and C-S-H insertion into cementitious nanocomposite." International Journal of Advanced Engineering Research and Science 5, no. 5 (2018): 14–19. http://dx.doi.org/10.22161/ijaers.5.5.2.

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11

Assarsson, Anna, Isabel Pastoriza-Santos, and Celia Cabaleiro-Lago. "Inactivation and Adsorption of Human Carbonic Anhydrase II by Nanoparticles." Langmuir 30, no. 31 (July 28, 2014): 9448–56. http://dx.doi.org/10.1021/la501413r.

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12

Touisni, Nadia, Nasreddine Kanfar, Sébastien Ulrich, Pascal Dumy, Claudiu T. Supuran, Ahmad Mehdi, and Jean-Yves Winum. "Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases." Chemistry - A European Journal 21, no. 29 (May 12, 2015): 10306–9. http://dx.doi.org/10.1002/chem.201501037.

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Touisni, Nadia, Nasreddine Kanfar, Sébastien Ulrich, Pascal Dumy, Claudiu T. Supuran, Ahmad Mehdi, and Jean-Yves Winum. "Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases." Chemistry - A European Journal 21, no. 29 (June 8, 2015): 10249. http://dx.doi.org/10.1002/chem.201501917.

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14

Novikov, Ilya V., Marina A. Pigaleva, Sergei S. Abramchuk, Vyacheslav S. Molchanov, Olga E. Philippova, and Marat O. Gallyamov. "Chitosan composites with Ag nanoparticles formed in carbonic acid solutions." Carbohydrate Polymers 190 (June 2018): 103–12. http://dx.doi.org/10.1016/j.carbpol.2018.02.076.

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15

Tatiparti, Katyayani, Mohd Ahmar Rauf, Samaresh Sau, and Arun K. Iyer. "Carbonic Anhydrase-IX Guided Albumin Nanoparticles for Hypoxia-mediated Triple-Negative Breast Cancer Cell Killing and Imaging of Patient-derived Tumor." Molecules 25, no. 10 (May 19, 2020): 2362. http://dx.doi.org/10.3390/molecules25102362.

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Triple-Negative Breast Cancer (TNBC) is considered as the most onerous cancer subtype, lacking the estrogen, progesterone, and HER2 receptors. Evaluating new markers is an unmet need for improving targeted therapy against TNBC. TNBC depends on several factors, including hypoxia development, which contributes to therapy resistance, immune evasion, and tumor stroma formation. In this study, we studied the curcumin analogue (3,4-Difluorobenzylidene Curcumin; CDF) encapsulated bovine serum albumin (BSA) nanoparticle for tumor targeting. For tumor targeting, we conjugated Acetazolamide (ATZ) with CDF and encapsulated it in the BSA to form a nanoparticle (namely BSA-CDF-ATZ). The in vitro cytotoxicity study suggested that BSA-CDF-ATZ is more efficient when compared to free CDF. The BSA-CDF-ATZ nanoparticles showed significantly higher cell killing in hypoxic conditions compared to normoxic conditions, suggesting better internalization of the nanoparticles into cancer cells under hypoxia. Fluorescent-dye labeled BSA-CDF-ATZ revealed higher cell uptake of the nanoparticle compared to free dye indicative of better delivery, substantiated by a high rate of apoptosis-mediated cell death compared to free CDF. The significantly higher tumor accumulation and low liver and spleen uptake in TNBC patient-derived tumor xenograft models confirm the significant potential of BSA-CDF-ATZ for targeted TNBC imaging and therapy.

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16

Doğan, Murat, Ümit Muhammet Koçyiğit, Duygu Taşkın, Beyza Nur Yılmaz, and Turgut Taşkın. "Preparation and characterization of chitosan nanoparticles with extracts of Rheum ribes, evaluation of biological activities of extracts and extract loaded nanoparticles." International Journal of Secondary Metabolite 11, no. 4 (September 9, 2024): 751–64. http://dx.doi.org/10.21448/ijsm.1425978.

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The biological activities of different parts of the Rheum ribes plant were evaluated comparatively. Extracts showing strong biological activity were identified and it was determined which of the extract-loaded nanoparticles showed stronger activity. Cytotoxic activity of R. ribes extracts was calculated on glial (C6) and fibroblast (NIH 3T3) cells using XTT assay. Spectrophotometry was used to evaluate the impact of these compounds on the enzyme activities of human carbonic anhydrase I and II (hCA I and hCA II). The findings showed that chitosan NPs with extracts loaded on them have a lower IC50 value and more cytotoxic activity in C6 cells than chitosan NPs with only extracts. R. ribes young shoots ultrasonic methanol extract (RYU) was shown to have the strongest antiproliferative efficacy against C6 cells. Results showed that RYU and ultrasonic methanol extract of R. ribes radix (RRU) were determined as the best carbonic anhydrase inhibitors. According to results of particle size, encapsulation efficiency, and release studies of chitosan NPs, it has been observed that they are suitable for application. At a concentration of 10 µg/mL, it was found that none of the R. ribes extracts exhibited cytotoxic action toward the NIH 3T3 cell line. According to results of particle size, encapsulation efficiency, and release studies of chitosan NPs, it has been observed that they are suitable for application. It was observed that none of the extracts of R. ribes at a concentration of 10 µg/mL showed cytotoxic activity in the NIH 3T3 cell line.

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Billsten, Peter, Uno Carlsson, Bengt Harald Jonsson, Gerd Olofsson, Fredrik Höök, and Hans Elwing. "Conformation of Human Carbonic Anhydrase II Variants Adsorbed to Silica Nanoparticles." Langmuir 15, no. 19 (September 1999): 6395–99. http://dx.doi.org/10.1021/la980288u.

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18

Ako-Adounvo, Ann-Marie, and Pradeep K. Karla. "Preparation and In Vitro Testing of Brinzolamide-Loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles for Sustained Drug Delivery." Journal of Clinical & Translational Ophthalmology 2, no. 1 (January 9, 2024): 1–14. http://dx.doi.org/10.3390/jcto2010001.

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Glaucoma therapy aims at lowering intra-ocular pressure (IOP). Brinzolamide, a carbonic anhydrase inhibitor, is utilized as a second-line medication for treating ocular hypertension and primary open-angle glaucoma (POAG). The drug lowers the IOP making it a therapeutic agent against glaucoma, and due to its poor water solubility, is commercially available as Azopt®, a 1% ophthalmic suspension. Adverse effects such as blurred vision, ocular irritation, discomfort, and bitter taste are associated with the use of the marketed brinzolamide formulation. This study aims to test the feasibility of formulating and in vitro testing of brinzolamide-PLGA nanoparticles for improved toxicity profile. The nanoparticles were prepared by the oil-in-water (O/W) emulsion-solvent evaporation method. Particle size and zeta potential were determined by dynamic light scattering (DLS). The morphology of the nanoparticles was determined by scanning electron microscopy (SEM). Encapsulation of the drug was verified by high-performance liquid chromatography (HPLC) and the compatibility of the polymer and drug was verified by Fourier transform infrared (FTIR) spectroscopy. The in vitro drug release profile was assessed employing the dialysis method. Intracellular localization of the nanoparticles was assessed by confocal microscopy utilizing Rhodamine 123-loaded nanoparticles. Cytotoxicity of the formulation was assessed on Statens Seruminstitut Rabbit Cornea (SIRC) and transfected Human Corneal Epithelial (SV40 HCEC) cell lines. The particle size of the nanoparticle formulations ranged from 202.3 ± 2.9 nm to 483.1 ± 27.9 nm for blank nanoparticles, and 129.6 ± 1.5 nm to 350.9 ± 8.5 nm for drug-loaded nanoparticles. The polydispersity of the formulations ranged from 0.071 ± 0.032 to 0.247 ± 0.043 for blank nanoparticles, and 0.089 ± 0.028 to 0.158 ± 0.004 for drug-loaded nanoparticles. Drug loading and encapsulation efficiencies ranged from 7.42–15.84% and 38.93–74.18%, respectively. The in vitro drug release profile for the optimized formulation was biphasic, with a ~54% burst release for the initial 3 h, followed by a cumulative 85% and 99% released at 24 and 65 h, respectively. Uptake study showed nanoparticles(NPs) localization in the cytoplasm and around the nuclei of the cells. Brinzolamide-PLGA nanoparticles were successfully developed, characterized, and tested in vitro. Preliminary data show intracellular localization of the nanoparticles in the cytoplasm of SIRC and SV40 HCEC cells. The formulations appeared to be relatively non-cytotoxic to the cells. The research data from the study provided preliminary data for successful development and promising in vitro absorption efficacy for brinzolamide-loaded PLGA nanoparticle formulation.

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Antal, Iryna, Martina Koneracka, Martina Kubovcikova, Vlasta Zavisova, Alena Jurikova, Iryna Khmara, Maria Omastova, et al. "Targeting of carbonic anhydrase IX-positive cancer cells by glycine-coated superparamagnetic nanoparticles." Colloids and Surfaces B: Biointerfaces 205 (September 2021): 111893. http://dx.doi.org/10.1016/j.colsurfb.2021.111893.

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Talebzadeh, Zeinab, Qahtan A. Yousif, Maryam Masjedi-Arani, and Masoud Salavati-Niasari. "Sonochemistry fabrication of Er2Sn2O7 nanoparticles with advanced photocatalytic performance of their carbonic nanocomposites." International Journal of Hydrogen Energy 47, no. 25 (March 2022): 12615–28. http://dx.doi.org/10.1016/j.ijhydene.2022.02.025.

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21

Shatokhin, A. N., A. V. Egorov, K. I. Maslakov, and F. N. Putilin. "Laser synthesis of metal–metaloxide nanoparticles on carbonic materials in an electric field." Bulletin of the Russian Academy of Sciences: Physics 80, no. 4 (April 2016): 387–92. http://dx.doi.org/10.3103/s1062873816040286.

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22

Al-Dhrub, Ahmed Hussein Ali, Selmihan Sahin, Ismail Ozmen, Ekrem Tunca, and Metin Bulbul. "Immobilization and characterization of human carbonic anhydrase I on amine functionalized magnetic nanoparticles." Process Biochemistry 57 (June 2017): 95–104. http://dx.doi.org/10.1016/j.procbio.2017.03.025.

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23

Yadav, Renu, Meenal Joshi, Snehal Wanjari, Chandan Prabhu, Swati Kotwal, T. Satyanarayanan, and Sadhana Rayalu. "Immobilization of Carbonic Anhydrase on Chitosan Stabilized Iron Nanoparticles for the Carbonation Reaction." Water, Air, & Soil Pollution 223, no. 8 (September 2, 2012): 5345–56. http://dx.doi.org/10.1007/s11270-012-1284-4.

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24

Novikov, Ilya V., Marina A. Pigaleva, Eduard E. Levin, Sergei S. Abramchuk, Alexander V. Naumkin, Helin Li, Andrij Pich, and Marat O. Gallyamov. "The mechanism of stabilization of silver nanoparticles by chitosan in carbonic acid solutions." Colloid and Polymer Science 298, no. 9 (June 16, 2020): 1135–48. http://dx.doi.org/10.1007/s00396-020-04683-8.

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25

Nie, Guo Chao, Di Si, Gwang Seong Kim, Zhong You Shi, Tanvi Siraj Ratani, Yong Eun Koo Lee, and Raoul Kopelman. "A Novel Nonionic, Multi-Surfactant System and Separation Method for the Synthesis of Active Carbonic Anhydrase Nanoparticles." Advanced Materials Research 399-401 (November 2011): 509–13. http://dx.doi.org/10.4028/www.scientific.net/amr.399-401.509.

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This paper describes a new synthesis and separation method of nanoparticles (NPs) using a non-toxic, non-ionic surfactant systems. The purification steps did not use ethanol or acetone. Results indicate that the wild type bovine Carbonic Anhydrase (CA) activity was enhanced almost 4 times more than the CA encapsulated NPs fabricated by the traditional method. The NPs have are more hydrophilic and also have a higher zeta potential. The well dispersed CA PAA NPs with of 10-30 nm in diameter were obtained. This work also demonstrates a universal method for immobilizing fragile biomacromolecules in NP carriers for biomedical applications.

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Bodor, Marius, Rafael M. Santos, Yi Wai Chiang, Maria Vlad, and Tom Van Gerven. "Impacts of Nickel Nanoparticles on Mineral Carbonation." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/921974.

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This work presents experimental results regarding the use of pure nickel nanoparticles (NiNP) as a mineral carbonation additive. The aim was to confirm if the catalytic effect of NiNP, which has been reported to increase the dissolution of CO2and the dissociation of carbonic acid in water, is capable of accelerating mineral carbonation processes. The impacts of NiNP on the CO2mineralization by four alkaline materials (pure CaO and MgO, and AOD and CC steelmaking slags), on the product mineralogy, on the particle size distribution, and on the morphology of resulting materials were investigated. NiNP-containing solution was found to reach more acidic pH values upon CO2bubbling, confirming a higher quantity of bicarbonate ions. This effect resulted in acceleration of mineral carbonation in the first fifteen minutes of reaction time when NiNP was present. After this initial stage, however, no benefit of NiNP addition was seen, resulting in very similar carbonation extents after one hour of reaction time. It was also found that increasing solids content decreased the benefit of NiNP, even in the early stages. These results suggest that NiNP has little contribution to mineral carbonation processes when the dissolution of alkaline earth metals is rate limiting.

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Antipov, S. A., T. A. Feduschak, O. V. Kokorev, Ye A. Gereng, G. Ts Dambayev, A. Ye Yermakov, M. A. Uymin, and I. A. Khlusov. "Antitumor in vitro and in vivo effects of lipid composites of cisplatin and ferromagnetic nanoparticles capsulated by carbonic coating." Bulletin of Siberian Medicine 9, no. 1 (February 28, 2010): 9–16. http://dx.doi.org/10.20538/1682-0363-2010-1-9-16.

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An investigation of in vitro and in vivo reaction of adenocarcinoma cells in conditions of direct contact with composites designed in a base of phospholipid concentrate, cisplatin and nanoparticles (diameter less than 10 nm) of iron capsulated by carbonic coating was the aim of paper. Their antitumor effect has been established to be conditioned by direct cytotoxic relatively elective action on malignant cell and, on the other hand, by stimulation of tumor node fibrosis. Proposed biotechnological approach that used low doses of cytostatic drug (1/10 LD50) and nanoferromagnetic particles (2 mg/kg) may be useful to design magnetocontrollable regimes for regional immuno(bio)therapy of cancer and its metastases.

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Perfetto, Rosa, Sonia Del Prete, Daniela Vullo, Giovanni Sansone, Carmela M. A. Barone, Mosè Rossi, Claudiu T. Supuran, and Clemente Capasso. "Production and covalent immobilisation of the recombinant bacterial carbonic anhydrase (SspCA) onto magnetic nanoparticles." Journal of Enzyme Inhibition and Medicinal Chemistry 32, no. 1 (January 1, 2017): 759–66. http://dx.doi.org/10.1080/14756366.2017.1316719.

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Peirce, S., M. E. Russo, R. Perfetto, C. Capasso, M. Rossi, R. Fernandez-Lafuente, P. Salatino, and A. Marzocchella. "Kinetic characterization of carbonic anhydrase immobilized on magnetic nanoparticles as biocatalyst for CO2 capture." Biochemical Engineering Journal 138 (October 2018): 1–11. http://dx.doi.org/10.1016/j.bej.2018.06.017.

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Khatibi, Ali, Leila Ma’mani, Reza Khodarahmi, Abbas Shafiee, Parvaneh Maghami, Faizan Ahmad, Nader Sheibani, and Ali Akbar Moosavi-Movahedi. "Enhancement of thermal reversibility and stability of human carbonic anhydrase II by mesoporous nanoparticles." International Journal of Biological Macromolecules 75 (April 2015): 67–72. http://dx.doi.org/10.1016/j.ijbiomac.2015.01.019.

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Nogalska, Adrianna, Mario Ammendola, Carla A. M. Portugal, Bartosz Tylkowski, Joao G. Crespo, and Ricard Garcia – Valls. "Polysulfone biomimetic membrane for CO2 capture." Functional Materials Letters 11, no. 05 (October 2018): 1850046. http://dx.doi.org/10.1142/s1793604718500467.

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Constant increase of greenhouse gas emission by human activity causes a climate change, with carbon dioxide as the main contributor. In nature, CO2 fixation takes place in leaves where carbonic anhydrase (CA) catalyzes the hydration reaction. Inspired by this photosynthesis process, we come with a polysulfone biomimetic membrane containing CA for CO2 capture. Two immobilization approaches were investigated: physical and chemical. For this reason, we prepared a blank polysulfone membrane to physically adsorb the enzyme on its surface, and a membrane with dispersed ferritic nanoparticles -NH2 terminated used for covalent binding of the enzyme. The scope of this study is to evaluate the influence of the immobilization type on the enzyme activity. The obtained nanoparticles and membranes were characterized by TEM, WAXD, EDX, SEM and CA, respectively. The attached amount was determined by ICP, whereas the activity and CO2 solubility were estimated experimentally. Studies showed that the enzyme is attached more efficiently by the physical adsorption. Nevertheless, covalent binding favors its activity by stabilizing the structure.

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Burunkova, J. A., I. Y. Denisyuk, Vera Bulgakova, and Sandor Kokenyesi. "TiO₂-Acrylate Nanocomposites Elaborated by UV-Curing with Tunable Properties." Solid State Phenomena 200 (April 2013): 173–77. http://dx.doi.org/10.4028/www.scientific.net/ssp.200.173.

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Abstract. Homogeneous TiO2–acrylate nanocomposite with low optical scattering were prepared by UV curing. The surface of the nanoparticles was modified by carbonic acids to control the aggregation between the nanoparticles. Effects of TiO2 content on the properties of nanocomposite (transmission, refractive index, mechanical properties, internal structure) were investigated. Depending on the composition of the matrix hard materials with high refractive index or light sensitive layers for holographic recording can be obtained. The first are interesting for medical applications, the last for photonics. For example, TiO2 nanocomposite was used for in situ fabrication of holographic gratings by interference lithography. Formation of the grating samples with high diffraction efficiency (20 %) is based on the light-stimulated mass-transport processes in the polymerized layer during the recording without any additional treatments. The relief formation has been investigated by AFM measurements too. These materials are designed for applications in integrated optics, elements of optics, in nanolithography.

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Stamer, Katerina S., Marina A. Pigaleva, Anastasiya A. Pestrikova, Alexander Y. Nikolaev, Alexander V. Naumkin, Sergei S. Abramchuk, Vera S. Sadykova, Anastasia E. Kuvarina, Valeriya N. Talanova, and Marat O. Gallyamov. "Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles." Molecules 27, no. 21 (October 26, 2022): 7261. http://dx.doi.org/10.3390/molecules27217261.

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Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed. This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology. Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel. The resulting composites demonstrate antimicrobial activity against both fungi and bacteria. Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size. Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction. The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.

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Stamer, K. S., M. A. Pigaleva, S. S. Abramchuk, and M. O. Gallyamov. "Principles of Gold Nanoparticles Stabilization with Chitosan in Carbonic Acid Solutions Under High CO2 Pressure." Doklady Physical Chemistry 495, no. 1 (November 2020): 166–70. http://dx.doi.org/10.1134/s0012501620110020.

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Lundqvist, Martin, Cecilia Andresen, Sara Christensson, Sara Johansson, Martin Karlsson, Klas Broo, and Bengt-Harald Jonsson. "Proteolytic Cleavage Reveals Interaction Patterns between Silica Nanoparticles and Two Variants of Human Carbonic Anhydrase." Langmuir 21, no. 25 (December 2005): 11903–6. http://dx.doi.org/10.1021/la050477u.

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Ahmadi, Mohammad Taghi, Neda Mousavi, Truong Khang Nguyen, Seyed Saeid Rahimian Koloor, and Michal Petrů. "Carbon Nanoparticle-Based Electro-Thermal Building Block." Applied Sciences 10, no. 15 (July 25, 2020): 5117. http://dx.doi.org/10.3390/app10155117.

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All around the world, researchers have raised concerns about the superlative geometrical, electronic, thermal, chemical and mechanical properties of carbon nanoparticles (CNPs). CNPs with low cost, high performance and prominent intrinsic properties have attracted extensive interest for numerous applications in various fields. Although CNPs have been studied mainly as transistors and sensors, they could also be considered as heat producers. However, this option has scarcely been studied. In this research, a CNP-based electro-thermal building block is synthesized by the arc discharge method in a carbonic medium (high-density polyethylene), and its behavior is investigated. It is shaped in the form of a metal–semiconductor–metal structure (MSM) between metallic electrodes, and in addition, the formation of two back-to-back Schottky diodes is analyzed and their use as CNP-based electro-thermal building blocks are reported.

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Yong, Joel K. J., Jiwei Cui, Kwun Lun Cho, Geoff W. Stevens, Frank Caruso, and Sandra E. Kentish. "Surface Engineering of Polypropylene Membranes with Carbonic Anhydrase-Loaded Mesoporous Silica Nanoparticles for Improved Carbon Dioxide Hydration." Langmuir 31, no. 22 (May 28, 2015): 6211–19. http://dx.doi.org/10.1021/acs.langmuir.5b01020.

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Touisni, Nadia, Nasreddine Kanfar, Sébastien Ulrich, Pascal Dumy, Claudiu T. Supuran, Ahmad Mehdi, and Jean-Yves Winum. "Cover Picture: Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases (Chem. Eur. J. 29/2015)." Chemistry - A European Journal 21, no. 29 (July 2, 2015): 10245. http://dx.doi.org/10.1002/chem.201590127.

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Akiyoshi, Kazunari, Yoshihiro Sasaki, and Junzo Sunamoto. "Molecular Chaperone-Like Activity of Hydrogel Nanoparticles of Hydrophobized Pullulan: Thermal Stabilization with Refolding of Carbonic Anhydrase B." Bioconjugate Chemistry 10, no. 3 (May 1999): 321–24. http://dx.doi.org/10.1021/bc9801272.

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Billsten, Peter, Per-Ola Freskgård, Uno Carlsson, Bengt-Harald Jonsson, and Hans Elwing. "Adsorption to silica nanoparticles of human carbonic anhydrase II and truncated forms induce a molten-globule-like structure." FEBS Letters 402, no. 1 (February 3, 1997): 67–72. http://dx.doi.org/10.1016/s0014-5793(96)01431-7.

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Assarsson, A., I. Nasir, M. Lundqvist, and C. Cabaleiro-Lago. "Kinetic and thermodynamic study of the interactions between human carbonic anhydrase variants and polystyrene nanoparticles of different size." RSC Advances 6, no. 42 (2016): 35868–74. http://dx.doi.org/10.1039/c6ra06175c.

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Farah M. Ghazal, Muna H. Jankeer, and Hafidh I. Al-Sadi. "Effect of Multi-Walled Carbon Nanotubes on lung tissue and concentration of enzyme Carbonic anhydrase in the New Zealand white rabbit." Tikrit Journal of Pure Science 22, no. 3 (January 27, 2023): 49–57. http://dx.doi.org/10.25130/tjps.v22i3.711.

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The aim of the present study was to investigate the effect of variable doses of Multi Carbon Nanotubes (MWCNTs) 1,3,5 mg/ml/kg body weight on lung weight and their effect on the concentration of Carbonic anhydrase(CA), morphological and histopathological changes of the males New Zealand white rabbits, In this study was used 40 New Zealand white rabbit of males, their ages range between (12-18 months) divided into four groups, ten for each group which intratracheal instillation with Nanoparticles, At days 7 and 90 post exposure, The blood , lung and trachea tissue samples were collected for each group. The exposure with Multi Walled Carbon Nanotubes led to significant increase in the lung weight of all groups by increasing the dose and the exposure period compared with control group, While the effect of carbon nanotubes in the lung function was represented by estimating the concentration of enzyme Carbonic anhydrase in blood serum that led to significant increase in the concentration of the enzyme for all groups compared with control group, And the effect of carbon nanotubes were studied on morphological and histological changes in each of the lung and trachea of exposure rabbit compared with control group, the morphological and histological changes in the lung and trachea of exposure rabbit with MWCNTs after 7 days of exposure, included whiting the upper surface of the lobes, sever infiltration of the mixed inflammatory cells (mono and polymorphonuclear), hyperatrophy of the tissue, muscular hyperatrophy of bronchi and fibrosis of the region, while after 90 days of exposure, the histological change were similar to that occurred after 7 days of exposure but more clear. Thus it shows that the lung was most affected organ by this tubes, which approved by histological examination of lung.

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Gómez-Ballesteros, Miguel, Vanessa Andrés-Guerrero, Francisco Parra, Jorge Marinich, Beatriz de-las-Heras, Irene Molina-Martínez, Blanca Vázquez-Lasa, Julio San Román, and Rocío Herrero-Vanrell. "Amphiphilic Acrylic Nanoparticles Containing the Poloxamer Star Bayfit® 10WF15 as Ophthalmic Drug Carriers." Polymers 11, no. 7 (July 19, 2019): 1213. http://dx.doi.org/10.3390/polym11071213.

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Topical application of drops containing ocular drugs is the preferred non-invasive route to treat diseases that affect the anterior segment of the eye. However, the formulation of eye drops is a major challenge for pharmacists since the access of drugs to ocular tissues is restricted by several barriers. Acetazolamide (ACZ) is a carbonic anhydrase inhibitor used orally for the treatment of ocular hypertension in glaucoma. However, large ACZ doses are needed which results in systemic side effects. Recently, we synthesized copolymers based on 2-hydroxyethyl methacrylate (HEMA) and a functionalized three-arm poloxamer star (Bayfit-MA). The new material (HEMA/Bayfit-MA) was engineered to be transformed into nanoparticles without the use of surfactants, which represents a significant step forward in developing new ophthalmic drug delivery platforms. Acetazolamide-loaded nanocarriers (ACZ-NPs) were prepared via dialysis (224 ± 19 nm, −17.2 ± 0.4 mV). The in vitro release rate of ACZ was constant over 24 h (cumulative delivery of ACZ: 83.3 ± 8.4%). Following standard specifications, ACZ-NPs were not cytotoxic in vitro in cornea, conjunctiva, and macrophages. In normotensive rabbits, ACZ-NPs generated a significant intraocular pressure reduction compared to a conventional solution of ACZ (16.4% versus 9.6%) with the same dose of the hypotensive drug (20 µg). In comparison to previously reported studies, this formulation reduced intraocular pressure with a lower dose of ACZ. In summary, HEMA:Bayfit-MA nanoparticles may be a promising system for ocular topical treatments, showing an enhanced ocular bioavailability of ACZ after a single instillation on the ocular surface.

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Yadav, Raman P., Sveeta V. Mhatre, and Amita A. Bhagit. "Biofabrication of Bifunctional Cerium Oxide Nanoparticles using Phaseolus vulgaris with Enhanced Antioxidant and Carbonic Anhydrase Class 1 Inhibitory Activity." MGM Journal of Medical Sciences 3, no. 4 (2016): 161–66. http://dx.doi.org/10.5005/jp-journals-10036-1117.

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Nasir, Irem, Martin Lundqvist, and Celia Cabaleiro-Lago. "Size and surface chemistry of nanoparticles lead to a variant behavior in the unfolding dynamics of human carbonic anhydrase." Nanoscale 7, no. 41 (2015): 17504–15. http://dx.doi.org/10.1039/c5nr05360a.

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46

Zhang, Shihan, Yongqi Lu, and Xinhuai Ye. "Catalytic behavior of carbonic anhydrase enzyme immobilized onto nonporous silica nanoparticles for enhancing CO2 absorption into a carbonate solution." International Journal of Greenhouse Gas Control 13 (March 2013): 17–25. http://dx.doi.org/10.1016/j.ijggc.2012.12.010.

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47

Sarah Abbas Hussein Al-saeed, Muhammed Mizher Radhi, and Zuhair Numan Hamed. "A Study into the Electrochemical Behavior of Nano Antibiotics as A Promising Treatment for Helicobacter Pylori Infection by Cyclic Voltammetry." Journal of Techniques 4, no. 33 (November 15, 2022): 12–20. http://dx.doi.org/10.51173/jt.v4i33.548.

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The helicobacter-pylori (H.pylori) bacteria that infects the digestive system is one of the bacteria that is intractable in routine treatments with antibiotics, as it has been studied using nano-antibiotics studied by the electrochemical behavior of three Nano antibiotics. The study aims to identify the extent of the effect of micro-antibiotics on the composition of the blood serum medium by electrochemical analysis using the cyclic voltammetric method and to compare it with nano-antibiotics. Three Nano-antibiotics such as Amoxicillin NPs, Azithromycin NPs, and Metronidazole NPs, and the mixture of the three nanoparticles as Nano-Kit were investigated in blood serum medium utilizing cyclic voltammetry methods by a glass carbonic electrode (GCE). The three nanoparticles in antibiotics were prepared by converting the micro antibiotic with a lyophilizer technique and characterization by field emission scanning electron microscopy (FESEM) with all antibiotics in Nano size. The results showed that all Nano compounds act as an antioxidant antibiotic in the blood serum medium. The study also included the electrochemical characterization of the Nano-kit of the mixture for the three Nano-biotics to prove anti-oxidative stress. It was found that the three nano-biotics have reduced current peaks without any oxidation peaks. The three nano-antibiotics can be an excellent treatment to eradicate H. pylori infection permanently. Therefore, the results of this research can be adapted to use the nano-kit of the mixture in the appropriate treatment of H.pylori infection.

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Tatiparti, Katyayani, Samaresh Sau, Kaustubh Gawde, and Arun Iyer. "Copper-Free ‘Click’ Chemistry-Based Synthesis and Characterization of Carbonic Anhydrase-IX Anchored Albumin-Paclitaxel Nanoparticles for Targeting Tumor Hypoxia." International Journal of Molecular Sciences 19, no. 3 (March 13, 2018): 838. http://dx.doi.org/10.3390/ijms19030838.

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Stiti, Maamar, Alessandro Cecchi, Marouan Rami, Mohamed Abdaoui, Véronique Barragan-Montero, Andrea Scozzafava, Yannick Guari, Jean-Yves Winum, and Claudiu T. Supuran. "Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II." Journal of the American Chemical Society 130, no. 48 (December 3, 2008): 16130–31. http://dx.doi.org/10.1021/ja805558k.

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Saada, Mohamed-Chiheb, Jean-Louis Montero, Daniela Vullo, Andrea Scozzafava, Jean-Yves Winum, and Claudiu T. Supuran. "Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms." Journal of Medicinal Chemistry 54, no. 5 (March 10, 2011): 1170–77. http://dx.doi.org/10.1021/jm101284a.

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