Relevant bibliographies by topics / Carbamazepine

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Carbamazepine'

Author: Grafiati
Published: 4 June 2021
Last updated: 21 February 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Carbamazepine.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Carbamazepine"

1

Eimer, Michelle, and Barry L. Carter. "Elevated Serum Carbamazepine Concentrations following Diltiazem Initiation." Drug Intelligence & Clinical Pharmacy 21, no. 4 (April 1987): 340–42. http://dx.doi.org/10.1177/106002808702100408.

Full text
Abstract:
A case of carbamazepine neurotoxicity following the addition of diltiazem is reported. A patient with previously stable carbamazepine serum concentrations was treated with diltiazem for atrial fibrillation and a rapid ventricular response. After three days on the combined regimen, the patient developed neurological symptoms resulting in hospitalization. After a review of the patient's medication usage and carbamazepine concentrations, an interaction between diltiazem and carbamazepine was suspected. Carbamazepine's elimination appears to have been decreased, resulting in neurotoxicity. The toxicity resolved when the carbamazepine dosage was decreased 62 percent.
APA, Harvard, Vancouver, ISO, and other styles
2

Citrome, Leslie. "Use of Lithium, Carbamazepine, and Valproic Acid in a State-Operated Psychiatric Hospital." Journal of Pharmacy Technology 11, no. 2 (March 1995): 55–59. http://dx.doi.org/10.1177/875512259501100210.

Full text
Abstract:
Objective: To examine the prescribing of mood stabilizers (lithium, carbamazepine, and valproic acid) in a 500-bed state-operated psychiatric hospital in New York. Method: All 129 inpatients receiving mood stabilizers were identified and their medical records reviewed using a standardized drug use evaluation form. Diagnosis, other indications, and prior experience with mood stabilizers were examined, as well as outcome and adverse effects. Results: Approximately one-quarter of the inpatient population received a mood stabilizer. The frequency of carbamazepine use exceeded the use of lithium, with 72 patients receiving carbamazepine and only 62 receiving lithium. Twenty-eight patients received valproic acid. Indications found most frequently for carbamazepine use included assaultive or aggressive behavior (70% for those receiving carbamazepine as the only mood stabilizer). Of those patients with bipolar or schizoaffective disorder and receiving either lithium, carbamazepine, or valproic acid, 36% were prescribed carbamazepine (10% as a first-line agent) and 50% lithium (26% as a first-line agent). None of these indications for carbamazepine has been approved by the Food and Drug Administration. In general, positive outcomes were documented but without supporting objective measures. Significant adverse effects were documented in the medical record in one-quarter of the patients. Conclusions: There was widespread use of the three mood stabilizers examined, singly and in combination, for a variety of indications. Lithium and valproic acid remain more frequently prescribed for the treatment of bipolar and schizoaffective disorders. Monotherapy with carbamazepine or valproic acid results in statistically significantly fewer adverse effects than lithium or combination therapy (p values between p = 0.00038 and p = 0.006). Current clinical practice has endorsed the use of carbamazepine for aggressive or assaultive behavior, although there does not appear to be sufficient proof of effectiveness in the literature. Formal studies of carbamazepine's antiagressive effects should be conducted.
APA, Harvard, Vancouver, ISO, and other styles
3

Sonbol, Heba, Hager Ebrahim, Monika Malak, Ahmed Ali, Yasmine Aboulella, Ghada Hadad, Samy Emara, and Ahmed Shawky. "Application of a Small Protein-Coated Column to Trap, Extract and Enrich Carbamazepine Directly from Human Serum for Direct Chromatographic Analysis." Separations 10, no. 2 (January 18, 2023): 71. http://dx.doi.org/10.3390/separations10020071.

Full text
Abstract:
An automated solid phase extraction (SPE) protocol to determine carbamazepine in human serum has been developed and validated using a simple, rabid and sensitive liquid chromatography-based bio-analytical method. Extraction of carbamazepine was carried out using an on-line SPE tool of a short protein-coated (PC) ODS silica pre-column (PC-ODS-pre-column) and phosphate buffer saline (PBS) with a pH of 7.4 as an extraction solvent. There are two distinct chromatographic modes used by PC-ODS-pre-column. While carbamazepine trapping required reversed-phase liquid chromatography, proteins were extracted from serum samples using PBS by size-exclusion liquid chromatography. Then, carbamazepine was eluted from the PC-ODS-pre-column onto the quantification position using a mixture of methanol-distilled deionized water (50:50, v/v) as an eluent and ODS analytical column. At room temperature (22 ± 1 °C), carbamazepine was completely separated from the co-eluted matrix components and detected at 230 nm. Carbamazepine’s linearity was obtained at concentrations ranging from 50 to 10,000 ng/mL. With good accuracy and precision, carbamazepine recoveries in serum samples ranged from 86.14 to 97.82%. The extraction step was conducted using PBS as a safe and green extraction solvent, making this protocol both cost-effective and ecologically safe.
APA, Harvard, Vancouver, ISO, and other styles
4

Damor, Rahul R., Amita R. Kubavat, and Kiran G. Piparva. "Drug reaction with eosinophilia and systemic symptom induced by carbamazepine: a case report." International Journal of Basic & Clinical Pharmacology 8, no. 5 (April 23, 2019): 1115. http://dx.doi.org/10.18203/2319-2003.ijbcp20191610.

Full text
Abstract:
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, potentially life-threatening acute adverse drug reaction (ADR), typically characterized by a long latency period (2-6 weeks to 3 months) from drug exposure. DRESS syndrome is defined by the presence of fever, cutaneous eruption, lymphadenopathy, systemic or asymptomatic internal organ involvement (e.g. Hepatitis, carditis, interstitial nephritis, interstitial pneumonitis, etc.) and haematological abnormalities, mainly leucocytosis, eosinophilia and sometimes atypical lymphocytosis. There are around 50 culprit drugs which cause DRESS syndrome e.g. carbamazepine, phenytoin, allopurinol, sulfa derivatives, antidepressants, antiepileptics, non-steroidal anti-inflammatory drugs and antimicrobials. The incidence of DRESS syndrome has been estimated to be between 1 in 1,000 and 1 in 10,000 drug exposures. There are many reported cases of DRESS syndrome due to carbamazepine, phenytoin, vancomycin, levitiracitam, ceftriaxone etc. Author presented a case of DRESS syndrome by carbamazepin. RegiSCAR and Japanese consensus group have developed specific criteria for making the diagnosis of DRESS syndrome. The patient described here met the majority of criteria according to RegiSCAR scoring guidelines for a diagnosis of DRESS syndrome induced by carbamazepine. As per RegiSCAR diagnostic criteria author had concluded that this was a “Definite” case of DRESS (Drug Reaction with Eosinophilia and Systemic Symptom) syndrome induced by carbamazepine. Carbamazepine is most common broad-spectrum antiepileptic drugs so, this case report will raises awareness among physician to suspect DRESS syndrome in patients who present unusual complaints and skin findings after starting antiepileptic drugs.
APA, Harvard, Vancouver, ISO, and other styles
5

&NA;. "Carbamazepine see Lithium/carbamazepine." Reactions Weekly &NA;, no. 303 (June 1990): 4. http://dx.doi.org/10.2165/00128415-199003030-00007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

&NA;. "Carbamazepine." Reactions Weekly &NA;, no. 1384 (January 2012): 16. http://dx.doi.org/10.2165/00128415-201213840-00058.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

&NA;. "Carbamazepine." Reactions Weekly &NA;, no. 1386 (January 2012): 14. http://dx.doi.org/10.2165/00128415-201213860-00047.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

&NA;. "Carbamazepine." Reactions Weekly &NA;, no. 1389 (February 2012): 15. http://dx.doi.org/10.2165/00128415-201213890-00046.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

&NA;. "Carbamazepine." Reactions Weekly &NA;, no. 1391 (March 2012): 15. http://dx.doi.org/10.2165/00128415-201213910-00052.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

&NA;. "Carbamazepine." Reactions Weekly &NA;, no. 1392 (March 2012): 15. http://dx.doi.org/10.2165/00128415-201213920-00041.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Carbamazepine"

1

Webster, Donald Shaw. "Studies of carbamazepine metabolism." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27680.

Full text
Abstract:
The objective of this study was to examine aspects of carbamazepine metabolism, in order to contribute to a long term goal of a thorough examination of how the metabolism of carbamazepine is influenced by other drugs. The first set of experiments were designed with the intent of determining values for the pharmacokinetic parameters of carbamazepine metabolism in male New Zealand white rabbits. Values were obtained for t[sub max] (60-90 min), t[sub ½](90-122 min), clearance (46.2-142.4 ml/min/kg), and the elimination constant (0.0057-0.0077 min⁻¹) in five test cases. In the remainder of cases, unexpected results were observed which did not allow calculation of these parameters. The plasma carbamazepine concentration was either delayed in reaching its peak concentration or it reached an apparent peak, but maintained that level for an extended period of time. It is thought that these differences between rabbits may have been due to differences in the rates of gastric emptying, a factor that may have been influenced by the food eaten by the animals in a period in excess of the 12 hours that some of the rabbits were fasted prior to the experiments. Alternatively, the time period of required sampling may have been underestimated. In addition, it is also possible that some degree of enterohepatic circulation is taking place. The relative positions of the curves for carbamazepine and for carbamazepine-10,11-epoxide suggest that there may be differences in the activities of hepatic monooxygenases and glucuronysyl transferases responsible for the metabolic fates of carbamazepine. The second set of experiments examined the influence of isoniazid and some of its principal metabolites on the conversion of carbamazepine to carbamazepine-10,11-epoxide in the S9 fraction of rat liver homogenate. This study is a prelude to planned in vivo studies of the interaction in rabbits. Three concentrations of each of isoniazid, acetyl hydrazine, acetylisoniazid, hydrazine, and isonicotinic acid were tested in a system containing constant concentrations of carbamazepine and of essential co-factors. The results indicated that there was a concentration dependent inhibition of carbamazepine metabolism by isoniazid, hydrazine, and isonicotinic acid. These types of experiments should expanded to include a range of carbamazepine concentrations so that an evaluation of the type of inhibition can be determined, as can be done Michaelis-Menton kinetics.
Medicine, Faculty of
Anesthesiology, Pharmacology and Therapeutics, Department of
Graduate
APA, Harvard, Vancouver, ISO, and other styles
2

Amore, Benny Michael. "Mechanism of carbamazepine teratogenicity /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/7939.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

VASSEUR, ROSINE. "La carbamazepine : indications en psychiatrie." Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF11039.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Terra, Luciana Assis 1988. "Avaliação de transformação polimórfica em comprimidos do fármaco carbamazepina por espectroscopia de imagem no infravermelho próximo e ferramentas quimiométricas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249298.

Full text
Abstract:
Orientador: Ronei Jesus Poppi
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química
Made available in DSpace on 2018-08-22T20:20:45Z (GMT). No. of bitstreams: 1 Terra_LucianaAssis_M.pdf: 5662002 bytes, checksum: 969f678029bf9ac1f5d8f5fadf9727f9 (MD5) Previous issue date: 2013
Resumo: A Espectroscopia de Imagem na região do Infravermelho Próximo juntamente com ferramentas quimiométricas foi utilizada para estudar a transformação polimórfica do fármaco carbamazepina (forma III para forma I) em formulações farmacêuticas do comprimido, geradas por aquecimento. Os mapas de distribuição de concentração das formas polimórficas I e III da carbamazepina no comprimido foram estimados por Mínimos Quadrados Parciais (PLS), Resolução Multivariada de Curvas (MCR) e Análise de Fatores Paralelos (PARAFAC), assim como o perfil de concentração em função do tempo durante o aquecimento, comparando os resultados obtidos quanto à eficácia na quantificação das formas polimórficas. Para o estudo da homogeneidade da distribuição do fármaco ao longo do comprimido, foram construídos histogramas. O trabalho está dividido em duas partes: na primeira parte foi realizado o mapeamento completo de um comprimido antes e após o aquecimento a 160 ºC, por 3 horas e os dados foram analisados por MCR. Na segunda parte do trabalho estudou-se a transformação polimórfica com o tempo a 140 ºC, em que foi realizado o mapeamento da parte central do comprimido, sendo nesse caso obtidas imagens a cada hora, com tempo total de 7 horas. Os resultados mostraram que os métodos PLS, MCR e PARAFAC foram capazes de obter informações sobre a transformação polimórfica, sendo MCR e PARAFAC capazes de estudar o processo dinâmico envolvido. Além disso, o MCR também foi capaz de fornecer os mapas de distribuição de concentrações em cada tempo de aquisição de dados, acompanhando a transformação polimórfica na superfície do comprimido
Abstract: The Near Infrared Chemical Imaging in conjunction with chemometric tools was used to study the polymorphic transformation of the drug carbamazepine (form III to form I) in pharmaceutical formulations tablets, generated by heating. The concentration distribution maps of the polymorphic forms I and III of carbamazepine in the tablet were estimated by Partial Least Squares (PLS), Multivariate Curve Resolution (MCR) and Parallel Factor Analysis (PARAFAC), as well as the concentration profile as a function of the heating time and the results were compared regarding the efficacy in quantification of the polymorphic forms. For the study of the homogeneity of distribution of the drug in the tablet, histograms were built. The work was divided into two parts: in the first part, it was conducted the mapping of the whole tablet before and after heating at 160 ºC for 3 hours and the data were analysed by MCR. In the second part, it was studied the polymorphic transformation over the time at 140 °C. Images of the central part of the tablet were obtained every hour during 7 hours. The results showed that the PLS, MCR and PARAFAC were able to obtain information about the polymorphic transformation and the MCR and PARAFAC were able to study the dynamic process involved as well. Furthermore, the MCR provided the concentration distribution map at each time of data acquisition, providing the polymorphic transformation on the tablet surface
Mestrado
Quimica Analitica
Mestra em Química
APA, Harvard, Vancouver, ISO, and other styles
5

Marlot, Philippe. "In vitro evaluation of cytotoxicity caused by carbamazepine and its metabolites in association to carbamazepine-induced hypersensitivity reactions." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2025988/.

Full text
Abstract:
Carbamazepine (CBZ), an anticonvulsant and mood-stabilising drug, is known to cause delayed type hypersensitivity reactions. These reactions occur only in a minority of patients treated with the drug, but often result in severe clinical outcomes. Although an association between CBZ-induced hypersensitivity reactions and HLA alleles has been demonstrated, the underlying mechanism(s) of toxicity are poorly understood. Cell death caused by CBZ and one of its metabolites, 9-acridinecarboxaldehyde (9-AC) was investigated. CBZ did not show cytotoxic effects in concentrations ranging from sub-therapeutic to supra-therapeutic. By contrast, 9-AC caused apoptosis in the lymphoblastoid cell line (50µM and 24 hours of exposure) and primary PBMCs (50 µM and 2 hours of exposure). PBMCs from 20 CBZ-naïve individuals showed significant inter-individual variability in the susceptibility to the cytotoxic effect of 9-AC. To further investigate the observed inter-individual variability, 331 immortalised lymphoblast cell lines of unrelated individuals from 4 populations were exposed to CBZ, CBZ-10,11 epoxide or 9-AC and cell viability was measured after 24 hour exposure. Considerable inter-individual variability in the cytotoxic response was observed for all three compounds. The genome wide association study (GWAS) revealed two genetic polymorphisms in dual oxidase 1 (DUOX1) and RP11-354|13.2 that were linked to cell toxicity at low concentrations of all three compounds. A SNP in DUOX1 was investigated further because of its biological plausibility. Genotyping of 153 patients did not show an association between this SNP and CBZ-induced hypersensitivity in Caucasians. Due to the higher than normal frequency of the DUOX1 variant in non-Caucasian patients (20%), the involvement of DUOX1 in the predisposition to CBZ-induced hypersensitivity reactions in non-Caucasians could not be excluded. To elucidate how T cell activation occurs in CBZ-induced hypersensitivity reactions, the protein binding capability of CBZ and two of its metabolites, CBZ-10,11 epoxide (CBZE) and 9-AC, to human serum albumin and glutathione S-transferase π was assessed. Only CBZE was found to bind covalently to these proteins. For 9-AC, no covalent products were observed but an indication of reversible binding was detected. Finally, newly developed genotyping methods for HLA-A*31:01 were investigated in comparison to sequence based typing. The methods were based on SSP-PCR. One of the methods showed exact accordance with the current gold standard but PCR failed to amplify the gene of interest and the control gene in considerable amount of samples (13.1%), while the second SSP-PCR typing method showed less reliability. In conclusion, the mechanisms of CBZ hypersensitivity has been investigated using a number of approaches designed to elucidate bioactivation of the drug, and how cytotoxicity links with genetic factors. The genomic approach may have the potential to identify novel biomarkers, but needs further studies with larger sample size.
APA, Harvard, Vancouver, ISO, and other styles
6

Alfirevic, Ana. "Molecular aspects of carbamazepine-induced hypersensitivity reactions." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421067.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Wurden, Colleen J. "Metabolism of carbamazepine and inhibitory drug interactions /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/7977.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Martins, Armando Carvalho de Oliveira. "Processo oxidativo avançado UV/H2O2 na oxidação da carbamazepina : avaliação por ensaios respirometricos e ecotoxicologicos." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/257867.

Full text
Abstract:
Orientador: Alexandre Nunes Ponezi
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo
Made available in DSpace on 2018-08-13T11:19:54Z (GMT). No. of bitstreams: 1 Martins_ArmandoCarvalhodeOliveira_M.pdf: 1218959 bytes, checksum: 89c4972bf88120caa1add6b7b1eb515a (MD5) Previous issue date: 2009
Resumo: O efeito da poluição é resultado inerente da ocupação humana com grande impacto ao ambiente. Um problema atual é a contaminação dos corpos d'água com produtos de origem industrial, agrícola e produtos de origem farmacológica e de cuidado pessoal. Os fármacos são considerados contaminantes ambientais devido a estas moléculas serem biologicamente ativas. Neste trabalho foi estudada a biodegradabilidade direta da carbamazepina, sua degradação por processo oxidativo avançado e por processo oxidativo avançado seguido de respirometria. Foi utilizado como metodologia a cromatografia em camada delgada, cromatografia líquida de alta eficiência, análises toxicológicas, respirométricas, demanda química de oxigênio e carbono orgânico total. A avaliação do potencial de biodegradação direta da carbamazepina por microrganismos provenientes do lodo ativado e do solo não apresentaram resultados satisfatórios. A melhor concentração de carbamazepina a ser utilizada no processo oxidativo, foi de 10 ppm. As análises de carbono orgânico total, referente ao processo de oxidação em reator de ultravioleta com peróxido de hidrogênio, realizadas após o tratamento mostraram que a taxa de remoção de carbono da solução foi de 1%. A análise da demanda química de oxigênio, realizada a partir das amostras geradas do reator nos tempos de reação de 5, 15, 30, 45 e 60 minutos não apresentou qualquer mudança significativa. Os ensaios de respirometria (biodegradação) mostraram uma degradação de aproximadamente 1% do composto químico para todos os tratamentos com ultravioleta com peróxido de hidrogênio utilizados. Nos testes de biodegradabilidade os microrganismos não foram capazes de utilizar o fármaco como fonte de carbono e energia mesmo após o tratamento com ultravioleta com peróxido de hidrogênio. A avaliação do desenvolvimento dos microrganismos durante o ensaio de biodegradação apresenta decréscimo acentuado do número de microrganismos viáveis presentes tanto para o composto puro como também para os ensaios realizados após o tratamento com ultravioleta com peróxido de hidrogênio. Os subprodutos gerados no processo oxidativo avançado apresentam efeitos tóxicos agudos para a Ceriodaphinia dúbia e Vibrio fischeri nos ensaios toxicológicos.
Abstract: Pollution is a direct result of human occupation. Since the big human conglomerates appeared became clear its harmfulness to the environment. Today there is a growing concern with water pollution by industrial, agricultural, pharmaceutical and personal care products. Pharmaceutical and personal care products contaminates the water in the domestic effluent, or in an inappropriate disposal of then in urban trash. The pharmaceutical products are considered environmental contaminants because their molecules are biologically actives. In this study the direct biodegradability of carbamazepine, its degradation by advanced oxidation process and advanced oxidation process followed by respirometry were evaluated. The total organic carbon, chemical oxygen demand, thin layer chromatography, high pressure liquid chromatography and respirometry were utilized to obtain the results of this work. The biodegradability results by microorganisms in soil and silt were not satisfying. An optimal concentration of 10ppm of carbamazepina was used in the advanced oxidation process. The total organic carbon results of the advanced oxidation process in UV/H2O2 reactor after the treatment revealed a removal rate of 1%. The respirometry assays showed less than 1% degradation of the chemical compound for all UV/H2O2 treatment. The results indicate that the microorganisms were not able to use the pharmaceutical product as a carbon and energy source even after UV/H2O2 treatment. The evaluation of microscopic development during the biodegradation assays revealed a drastic fall in the number of viable microorganisms presents in the pure compound as well as after the advanced oxidation process. The toxicological assays showed that the advanced oxidation process generated sub products and have acute toxicological effects for Ceriodaphinia dúbia and Vibrio fischeri.
Mestrado
Saneamento e Ambiente
Mestre em Engenharia Civil
APA, Harvard, Vancouver, ISO, and other styles
9

Panesar, Sukhbinder Kaur. "The effect of carbamazepine on valproic acid metabolism." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26511.

Full text
Abstract:
Modifications to the GCMS assay for valproic acid and 12 metabolites were attempted with respect to internal standards and derivatizing reagents. Four new internal standards, octanoic acid and 2-methylglutaric acid for analysis of VPA and metabolites and hexanoic acid and di-ռ-butylacetic acid for the analysis of hexadeuterated VPA and metabolites were used. Two new derivatizing reagents, MSTFA and MTBSTFA, were tested as alternatives to the reagent previously used. TMS (MSTFA) and tBDMS derivatives were compared with respect to sensitivity, stability, and chromatographic time. The derivatives formed from MTBSTFA were extremely stable a major drawback was the formation of a diderivative of 3-keto VPA upon increased heating time and storage. Preliminary data on the metabolism of D₆-VPA was obtained in one volunteer. The substitution of six deuterium atoms for six hydrogen atoms resulted in an isotope effect with decreased serum trough concentrations of 4-ene VPA and 2,4-diene VPA. Valproic acid and carbamazepine are frequently coadministered in efforts to optimize seizure control. VPA is extensively metabolized while CBZ is known to induce the hepatic microsomal enzyme system, and thus, this is a potentially toxic interaction. Pharmacokinetic parameters for VPA were obtained before and after CBZ administration in five, healthy male volunteers. Increased plasma clearance of VPA accompanied by decreased plasma concentrations, serum half-life, and AUC values were observed after CBZ comedication. This was consistent with the ability of CBZ to induce the hepatic microsomal enzyme systems in a manner similar to phenobarbital. Serum trough and steady state concentrations and AUC values for 12 metabolites were determined before and after CBZ administration. The AUC values for the monounsaturated metabolites decreased after CBZ administration while the AUC values of the polar metabolites increased. The amount of 4-ene VPA, a potential hepatotoxin, was not increased in the serum after administration of CBZ. The amounts of the two diunsaturated metabolites, 2,3'-diene VPA and 2,4-diene VPA, were increased in the serum of the volunteers after CBZ administration. The amount of 2-ene trans VPA in the serum was significantly decreased after CBZ administration, while the amount of 3-keto VPA did not increase. Urinary metabolic profiles were determined individually and grouped in pathways for the five volunteers before and after CBZ administration. Increased recoveries of 4-ene VPA, 4-keto VPA, and 2-PSA after CBZ administration were consistent with enhanced ω-1 oxidation. Formation clearance, metabolic clearance, and fraction metabolized were determined for the metabolic pathways and for the individual metabolites. CBZ adminstration resulted in increased formation clearances for all pathways. The results obtained from this study indicate that CBZ caused a general induction of VPA metabolism and did not specifically affect a particular pathway. The effect of CBZ on the beta-oxidation pathway is not clearly understood. CBZ may cause a metabolic shift away from beta-oxidation, or actually inhibit beta-oxidation to some extent. As well, peroxisomal beta-oxidation may be involved.
Pharmaceutical Sciences, Faculty of
Graduate
APA, Harvard, Vancouver, ISO, and other styles
10

Yip, V. L. M. "Carbamazepine hypersensitivity : linking metabolism to the immune response." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3002243/.

Full text
Abstract:
Carbamazepine (CBZ) is an effective antiepileptic drug but has been associated with hypersensitivity reactions in up to 10% of patients. These reactions range from mild maculopapular exanthema to life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. The identification of CBZ-specific T cells and strong associations with specific human leukocyte antigen alleles provide evidence for immunological involvement. CBZ is extensively metabolised and forms several reactive metabolites. The aim of this thesis was to investigate the complex relationships between CBZ, its metabolism, the immune system, and genomics. Direct and microsomal incubations demonstrated that carbamazepine 10,11-epoxide (CBZE), the major metabolite of CBZ, formed a protein conjugate with human serum albumin (HSA) at His146. The same CBZE-modified HSA was also detected in patients tolerant of CBZ therapy. A second His146 CBZ-modified HSA adduct was identified in microsomal incubations, formed as a product of arene oxide providing the first chemical evidence that reactive metabolites of CBZ can modify soluble proteins. Healthy volunteers (n=8) and patients prescribed CBZ therapy (n=72) were recruited to investigate the influence of genetic variation on CBZ metabolism. Patient demographics and a mixture of rich and sparse pharmacokinetic (PK) samples were collected. Plasma levels of CBZ and four major metabolites were measured using a novel high performance liquid chromatography tandem mass spectrometric assay. There was significant variation in observed plasma concentrations of CBZ (14-fold) and its metabolites (approximately 30-fold). A population PK model was developed with nonlinear mixed effects modelling using the PK and clinical data collected from patients. Completion of autoinduction, total daily dosage and concomitant therapy with phenytoin were significant covariates that influenced the CBZ PK. Analysis of variance demonstrated that two single nucleotide polymorphisms (SNPs) in the gene ABCB1 and a single SNP in EPHX1 were significantly associated with altered plasma concentrations of CBZE. T cell clones (TCCs) were generated to CBZ and CBZE from two patients with a history of hypersensitivity to CBZ. All TCCs were CD4+ and secreted the cytokines IFN-γ, IL-13, granzyme B and perforin. TCC activation was MHC class II restricted and all TCCs were stimulated when CBZ was freshly added into the incubation mixture indicative of direct activation. A single TCC was activated when antigen presenting cells (APCs) were pulsed with CBZ indicative of a hapten mechanism. Transcriptomic analysis of peripheral blood mononuclear cells (PBMCs) from patients with a known history of CBZ hypersensitivity identified 9 CBZ/CBZE-specific mRNA and 39 CBZ/CBZE- miRNA transcripts. Pathway analysis mRNA and miRNA changes showed that antiviral response, psoriasis and inflammation were the most significant functions associated with exposure of cells from cases to CBZ and CBZE. In conclusion, these studies show that CBZ is transformed to stable and reactive metabolites, and these metabolites together with the parent drug, lead in susceptible individuals to an orchestrated response which involves transcriptional and immunological activation.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Carbamazepine"

1

Medenwald, Janet R. Carbamazepine and manic depression : a guide. Rev. ed: Lithium Information Center/Dean Foundation for Health, Research and Education, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Internationales Carbamazepin Slow-Release Symposium (2nd 1986 Frankfurt am Main). 2. Internationales Carbamazepin Slow-Release Symposium, Frankfurt am Main, Dezember 1986. München: W. Zuckschwerdt, 1988.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Greil, Waldemar. Manic depressive illness: Therapy with carbamazepine : for patients, relatives and therapists. Stuttgart: Thieme, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

McDermott, Elaine Elizabeth. Inositol lipid hydrolysis in the rat hippocampus: Effects of the anticonvulsant carbamazepine. Birmingham: University of Birmingham, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Johnson, Robert D. False carbamazepine positives due to 10,11-dihydro-10-hydroxycarbamazepine breakdown in the GC/MS injector port. Washington, D.C: Federal Aviation Administration, Office of Aerospace Medicine, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Parker, Philip M., and James N. Parker. Tegretol: A medical dictionary, bibliography, and annotated research guide to internet references. San Diego, CA: ICON Health Publications, 2004.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

1954-, Joffe Russell T., and Calabrese Joseph R, eds. Anticonvulsants in mood disorders. New York: M. Dekker, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Carbamazepine in affective disorder. CNS (Clinical Neuroscience), 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Cavanna, Andrea E. Carbamazepine, oxcarbazepine, and eslicarbazepine. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198791577.003.0003.

Full text
Abstract:
Carbamazepine is a first-generation antiepileptic drug characterized by a good range of antiepileptic indications, with acceptable risk of interactions in polytherapy. Carbamazepine has a very good behavioural tolerability profile and is in widespread psychiatric use (indication for bipolar disorder—acute mania). Oxcarbazepine and eslicarbazepine are carbamazepine derivatives. Oxcarbazepine is a second-generation antiepileptic drug characterized by a good range of antiepileptic indications, with acceptable risk of interactions in polytherapy. Like carbamazepine, oxcarbazepine has a very good behavioural tolerability profile and potential for widespread psychiatric use. Eslicarbazepine is a third-generation antiepileptic drug for which clinical experience is still limited. Little is known about its positive and negative psychotropic properties and their implications for the management of behavioural symptoms in patients with epilepsy.
APA, Harvard, Vancouver, ISO, and other styles
10

Jefferson, James W., and John H. Greist. Carbamazepine & Manic Depression: A Guide. Madison Inst of Medicine, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Carbamazepine"

1

Maxwell, Robert A., and Shohreh B. Eckhardt. "Carbamazepine." In Drug Discovery, 193–206. Totowa, NJ: Humana Press, 1990. http://dx.doi.org/10.1007/978-1-4612-0469-5_15.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Courtney, John C. "Carbamazepine." In Encyclopedia of Clinical Neuropsychology, 487–88. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1635.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Courtney, John C., and Efrain Antonio Gonzalez. "Carbamazepine." In Encyclopedia of Clinical Neuropsychology, 1–2. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1635-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gonzalez, Efrain Antonio. "Carbamazepine." In Encyclopedia of Clinical Neuropsychology, 1–2. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-56782-2_1635-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Gonzalez, Efrain Antonio. "Carbamazepine." In Encyclopedia of Clinical Neuropsychology, 682–83. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1635.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, Sarah Parylak, Micaela Morelli, Nicola Simola, Nicola Simola, et al. "Carbamazepine." In Encyclopedia of Psychopharmacology, 274. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1767.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Patsalos, P. N. "Carbamazepine." In Antiepileptic Drug Interactions, 11–21. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2434-4_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Patsalos, P. N. "Carbamazepine." In Antiepileptic Drug Interactions, 199–213. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2434-4_29.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Panayiotopoulos, C. P. "Carbamazepine." In Antiepileptic Drugs, Pharmacopoeia, 7–11. London: Springer London, 2010. http://dx.doi.org/10.1007/978-0-85729-012-0_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Dickinson, R. G., M. J. Eadie, and E. J. E. Vajda. "Carbamazepine." In Antiepileptic Drugs, 267–317. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-60072-2_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Carbamazepine"

1

Pino, Esteban J., Francisca Pucheu, Fabian Alvarado, Britam Gomez, Marta De Diego, Sigrid Mennickent, Claudio Aguayo, Carlos Pena, and Andres Rodriguez. "Carbamazepine Biosensor Development for Epilepsy Patient Screening." In 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2021. http://dx.doi.org/10.1109/embc46164.2021.9629901.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Bayer, A., E. Zrenner, H. J. Thiel, S. Ried, and D. Schmidt. "Early detection of anticonvulsant drug toxicity by colour vision tests." In Noninvasive Assessment of the Visual System. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/navs.1991.md10.

Full text
Abstract:
Phenytoin and Carbamazepine, especially in combination or after repeated exposure to toxic blood concentrations, can produce neurological and mental syndroms. Possible mechanisms of impaired neurological and mental function include neuronal damage, or disturbance of folic acid, monoamine or hormonal metabolism. Phenytoin and Carbamazepine may also impair the ocular system. The most common symptoms are diplopia, nystagmus and blurred vision. Cerebellar or vestibulo-ocular dysfunction is suspected as mechanism of these ocular adverse effects.
APA, Harvard, Vancouver, ISO, and other styles
3

Ramle, Noor Ashila, Syarifah Abd Rahim, Nornizar Anuar, and Omar El-Hadad. "Solubility of carbamazepine co-crystals in ethanolic solution." In 3RD INTERNATIONAL CONFERENCE ON CHEMICAL MATERIALS AND PROCESS (ICCMP 2017). Author(s), 2017. http://dx.doi.org/10.1063/1.5000468.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Mizner, A. M., M. Bahr, A. Gordon, and D. Speredelozzi. "The Paradoxical Effect: Carbamazepine Overdose Leading to Seizures." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2925.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Pajander, Jari, Alexia Rensonnet, Marin Øvergård, Martin Olsen, Gina Fisher, Stefania Baldursdottir, and Jukka Rantanen. "Polymorphic transition of carbamazepine during hot melt processing." In The 2nd Electronic Conference on Pharmaceutical Sciences. Basel, Switzerland: MDPI, 2012. http://dx.doi.org/10.3390/ecps2012-00815.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Hussein, Sama Ali, Abdulmonaim Hamad Al-Samarrai, and Liqaa Hussein Alwan. "Spectroscopic study of carbamazepine on a new nanomaterial." In 1ST SAMARRA INTERNATIONAL CONFERENCE FOR PURE AND APPLIED SCIENCES (SICPS2021): SICPS2021. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0122477.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Yuksek, Gulten, Lounes Haroune, Didem Okutman Tas, and Hubert Cabana. "Laccase-Mediator System for the Elimination of Carbamazepine and Atrazine." In International Conference of Recent Trends in Environmental Science and Engineering. Avestia Publishing, 2017. http://dx.doi.org/10.11159/rtese17.126.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Silva, Rodrigo A. L., Daniel F. S. Machado, Luciano Ribeiro, Heibbe C. B. de Oliveira, and Demétrio A. da Silva Filho. "Theoretical Study of Doped Fullerene for Transport and Detection of Carbamazepine." In VII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Editora Letra1, 2018. http://dx.doi.org/10.21826/9788563800374010.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Vivisenco, Iolanda, Nistor Nicolai, Mihai Gafencu, Aurel Bizo, Bogdan Bulata, and Coriolan Emil Ulmeanu. "P369 Acute poisoning with carbamazepine in children – a prospective multicentre study." In 8th Europaediatrics Congress jointly held with, The 13th National Congress of Romanian Pediatrics Society, 7–10 June 2017, Palace of Parliament, Romania, Paediatrics building bridges across Europe. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313273.457.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Pogacean, F., A. R. Biris, C. Socaci, V. Floare-Avram, M. C. Rosu, M. Coros, and S. Pruneanu. "Electrochemical degradation of carbamazepine using modified electrode with graphene-AuAg composite." In 10TH INTERNATIONAL CONFERENCE PROCESSES IN ISOTOPES AND MOLECULES (PIM 2015). AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4938453.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Carbamazepine"

1

Owens, J. E., A. K. Vu, and B. K. Esser. California GAMA Special Study: Analysis of Carbamazepine, Oxcarbazepine and Metabolites as Wastewater Tracers in Water Resource Studies. Office of Scientific and Technical Information (OSTI), August 2010. http://dx.doi.org/10.2172/1119929.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Asenath-Smith, Emily, Emma Ambrogi, Lee Moores, Stephen Newman, and Jonathon Brame. Leveraging chemical actinometry and optical radiometry to reduce uncertainty in photochemical research. Engineer Research and Development Center (U.S.), September 2021. http://dx.doi.org/10.21079/11681/42080.

Full text
Abstract:
Subtle aspects of illumination sources and their characterization methods can introduce significant uncertainty into the data gathered from light-activated experiments, limiting their reproducibility and technology transition. Degradation kinetics of methyl orange (MO) and carbamazepine (CM) under illumination with TiO₂ were used as a case study for investigating the role of incident photon flux on photocatalytic degradation rates. Valerophenone and ferrioxalate actinometry were paired with optical radiometry in three different illumination systems: xenon arc (XE), tungsten halogen (W-H), and UV fluorescent (UV-F). Degradation rate constants for MO and CM varied similarly among the three light systems as k W-H < kiv-F < kXE, implying the same relative photon flux emission by each light. However, the apparent relative photon flux emitted by the different lights varied depending on the light characterization method. This discrepancy is shown to be caused by the spectral distribution present in light emission profiles, as well as absorption behavior of chemical actinometers and optical sensors. Data and calculations for the determination of photon flux from chemical and calibrated optical light characterization is presented, allowing us to interpret photo-degradation rate constants as a function of incident photon flux. This approach enabled the derivation of a calibrated ‘rate-flux’ metric for evaluating and translating data from photocatalysis studies.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Carbamazepine' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography