Relevant bibliographies by topics / Carba analogue

Academic literature on the topic 'Carba analogue'

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Published: 9 March 2023

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Journal articles on the topic "Carba analogue"

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Thuring, Jan Willem J. F., Gerard H. L. Nefkens, and Binne Zwanenburg. "Synthesis and Biological Evaluation of the Strigol Analogue Carba-GR24." Journal of Agricultural and Food Chemistry 45, no. 4 (April 1997): 1409–14. http://dx.doi.org/10.1021/jf960443f.

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Boyer, Paul L., B. Christie Vu, Zandrea Ambrose, John G. Julias, Svenja Warnecke, Chenzhong Liao, Chris Meier, Victor E. Marquez, and Stephen H. Hughes. "The Nucleoside Analogue D-carba T Blocks HIV-1 Reverse Transcription." Journal of Medicinal Chemistry 52, no. 17 (September 10, 2009): 5356–64. http://dx.doi.org/10.1021/jm801176e.

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Lefoix, Myriam, Arnaud Tatibouët, Sylvain Cottaz, Hugues Driguez, and Patrick Rollin. "Carba-glucotropaeolin: the first non-hydrolyzable glucosinolate analogue, to inhibit myrosinase." Tetrahedron Letters 43, no. 16 (April 2002): 2889–90. http://dx.doi.org/10.1016/s0040-4039(02)00463-x.

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Zhang, Xini, Bradley J. Berger, and Peter Ulrich. "Synthesis and trypanocidal activity of the bis-carba analogue of pentamidine." Bioorganic & Medicinal Chemistry Letters 6, no. 9 (May 1996): 1035–36. http://dx.doi.org/10.1016/0960-894x(96)00168-0.

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Tilbrook, Matthew G., Robert V. Stick, and Spencer J. Williams. "β-Acarbose. VII. Approaches Towards the Synthesis of Some N-Linked Carba-Oligosaccharides." Australian Journal of Chemistry 52, no. 9 (1999): 885. http://dx.doi.org/10.1071/ch99030.

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3,4-Anhydro-1,6-dideoxy-1,6-episeleno-β-D-glucose was treated with cyclohexylamine to afford an amino diol which was subsequently converted into a cyclic carbamate, a compound shown to be a moderately successful glycosyl donor. Treatment of the same 3,4-anhydro sugar and the 1,6-epithio analogue with a 1-epivalienamine derivative afforded the corresponding secondary amines which were converted into the analogous cyclic carbamates. The epithio analogue was unsuccessful as a glycosyl donor, failing to glycosylate a carbohydrate alcohol. On the other hand, the episeleno compound appeared to function as a glycosyl donor but decomposition of the product occurred under the conditions necessary for its isolation.
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Atke, Anders, and Hans Vilhardt. "Uterotonic activity and myometrial receptor affinity of 1-deamino-1-carba-2-tyrosine(O-methyl)-oxytocin." Acta Endocrinologica 115, no. 1 (May 1987): 155–60. http://dx.doi.org/10.1530/acta.0.1150155.

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Abstract. The contractile effect of the analogue 1-deamino-1-carba-2-tyrosine(O-methyl)-oxytocin (carbetocin) on isolated myometrial strips from rats was compared with that of oxytocin. The uterotonic activity of the analogue was 15 ± 3 IU/mg as compared with 438 ± 41 for oxytocin, however, the response was more prolonged and could not be abolished by washing of the preparation. Despite the low biological activity of carbetocin, its binding affinity to receptors of isolated myometrial plasma membranes was of the same order of magnitude as that of oxytocin. On the basis of the present results it is concluded that a longer half-life of the analogue at the receptor compartment may be a contributing factor to the prolonged uterotonic effect observed in vivo.
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Campbell, Malcolm M., Malcolm Sainsbury, Philip A. Searle, and Gareth M. Davies. "Synthesis of methyl (−)-homogabaculinate and a carba analogue of 5-enolpyruvylshikimic acid." Tetrahedron Letters 33, no. 22 (May 1992): 3181–84. http://dx.doi.org/10.1016/s0040-4039(00)79846-7.

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Lefoix, Myriam, Arnaud Tatibouet, Sylvain Cottaz, Hugues Driguez, and Patrick Rollin. "ChemInform Abstract: Carba-glucotropaeolin: The First Non-Hydrolyzable Glucosinolate Analogue, to Inhibit Myrosinase." ChemInform 33, no. 32 (May 20, 2010): no. http://dx.doi.org/10.1002/chin.200232204.

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Hřebabecký, Hubert, and Antonín Holý. "Synthesis of Carbocyclic 4'-C-Hydroxymethyl Analogues of Azidodeoxythymidine, Deoxythymidine, Deoxydidehydrothymidine and Thymidine Carba Analogue with Fused Oxetane Ring." Collection of Czechoslovak Chemical Communications 65, no. 3 (2000): 395–406. http://dx.doi.org/10.1135/cccc20000395.

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Tosylation of (±)-1-[trans-4-hydroxy-3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)-dione (1) and (±)-1-[cis-4-hydroxy-3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)-dione (2) and treatment of the obtained 1-{(1R*,3R*,4S*)- 4-hydroxy-3-(hydroxymethyl)-3-[(tosyloxy)methyl]cyclopentyl}-5-methylpyrimidine- 2(1H),4(3H)-dione (6) and 1-{(1R*,3S*,4R*)-4-hydroxy-3-(hydroxymethyl)-3-[(tosyloxy)- methyl]cyclopentyl}-5-methylpyrimidine-2(1H),4(3H)-dione (9) with methanolic sodium methoxide gave 1-[(1R*,4S*,6S*)-4-hydroxymethyl-2-oxabicyclo[3.2.0]hept-6-yl]-5-methylpyrimidine-2(1H),4(3H)-dione (7) and 1-[(1R*,4S*,6R*)-4-hydroxymethyl-2-oxabicyclo[3.2.0]hept-6-yl]-5-methylpyrimidine-2(1H),4(3H)-dione (10), respectively. Treatment of (±)-1-{cis-4-mesyloxy-3,3-bis[(trityloxy)methyl]cyclopentyl}-5-methylpyrimidine-2(1H),4(3H)-dione (11), which was prepared from 2 by tritylation and mesylation, with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethylformamide afforded after deprotection (±)-1-[4,4-bis(hydroxymethyl)cyclopent-2-en-1-yl]-5-methylpyrimidine-2(1H),4(3H)-dione (14). Hydrogen- ation of 14 led to (±)-1-[3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)- dione (15). (±)-1-{trans-4-Mesyloxy-3,3-bis[(trityloxy)methyl]cyclopentyl}-5-methylpyrimidine- 2(1H),4(3H)-dione (17), which was prepared from 1, was converted to (1R*,9R*)-6-methyl-5-oxo-11,11-bis(trityloxymethyl)-2-oxa-4,8-diazatricyclo[7.2.1.03,8]dodec-3,6-diene (18). The compound 18 was deprotected and heated with lithium azide in dimethylformamide to give (±)-1-[trans-4-azido-3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)-dione (21).
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Norström, Anders, Ann Andersson, and Hans Vilhardt. "Contractile effect of oxytocin and 1-deamino-1-carba-2-tyrosine (O-methyl)-oxytocin in myometrial tissue from non-pregnant and term pregnant women." Acta Endocrinologica 122, no. 5 (May 1990): 566–68. http://dx.doi.org/10.1530/acta.0.1220566.

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Abstract. The contractile effect of the analogue 1-deamino-1-carba-2-tyrosine (O-methyl)-oxytocin (carbetocin) on isolated strips from the human myometrium was compared with that of oxytocin. Neither oxytocin nor carbetocin affected contractile activity in strips from nonpregnant women, but both peptides stimulated contractile activity in strips from women at term pregnancy (2× 10−11 mol/l, and 10−10 mol/l, respectively). Thus, carbetocin is almost as potent as oxytocin with regard to stimulating myometrial contractions at term.
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Dissertations / Theses on the topic "Carba analogue"

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Williams, Paula Mary. "Studies towards the chemo-enzymatic synthesis of carba-GDP-mannose; A mannosyl transferase donor substrate analogue." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534664.

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AUBERGER, LUDOVIC CHRISTIAN. "Synthesis of Neisseria meningitidis serogroup A carba analogues as hydrolytically stable antigens for antimeningococcal glycoconjugate vaccines." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/687105.

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Synthesis of Neisseria meningitidis serogroup A carba analogues as hydrolytically stable antigens for antimeningococcal glycoconjugate vaccines Ludovic Auberger, Jacopo Enotarpi, Jeroen Codeé, Roberto Adamo, Laura Polito, Luigi Lay The Gram-negative encapsulated bacterium Neisseria meningitidis type A (MenA) is a major cause of meningitis in developing countries, especially in the sub-Saharan region of Africa [1]. The development and manufacture of an efficient glycoconjugate vaccine against MenA is largely hampered by the poor stability in water of the natural capsular polysaccharide (CPS)[2], composed of (1→6)-linked 2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating units, with acetyl substituents. As a consequence, most of MenA glycoconjugates currently available have been licensed as lyophilisates. The availability of MenA polysaccharide mimics resistant to hydrolysis, however, is highly attractive for the development of a more stable glycoconjugate vaccine in liquid formulation. To this end, we envisaged that the replacement of the endocyclic ring oxygen with a methylene group to get a carbocyclic analogue will lead to the loss of the acetalic character of the phosphodiester and consequently to the enhancement of its chemical stability [3], [4]. Furthermore, the 3-O-acetylation aims to strengthen the immunological profile of our neo-glycoconjugates, structurally designed even closer to the natural CPS MenA oligomer, partially acetylated at the position 3-OH with a rate of 75-95% [5]. Thus, we describe our synthetic approaches to 3-O-acetylated phosphodiester-linked carba oligomers of N-acetyl mannosamine (the repeating unit of MenA CPS, containing up to 8 repeating units. The increased stability of the synthetic carba oligomers was first confirmed by an accelerated stability study, then selected fragments were conjugated to CRM197 (a diphtheria toxin mutant) as a protein carrier. Finally, the immunological profile of the resulting neo-glycoconjugates will be carefully investigated, with the purpose to highlight the effect of the carbohydrate chain length and of the 3-O-acetylation on the immunoactivity [6]. [1] Tan L. K. K.; Carlone G. M.; Borrow R. Advances in the development of vaccines against Neisseria meningitidis. N. Engl. J. Med. 2010, 362, 1511-1520. [2] Frasch, C. E. Production and control of Neisseria meningitidis vaccines. Adv. Biotechnol. Processes 1990, 13, 123-145. [3] Gao, Q.; Zaccaria, C.; Tontini, M.; Poletti, L.; Costantino, P.; Lay, L. Synthesis and preliminary biological evaluation of carba analogues from Neisseria meningitidis A capsular polysaccharide. Org. Biomol. Chem. 2012, 10, 6673-6681. [4] Gao Q.; Tontini M.; Brogioni G.; Nilo A.; Filippini S.; Harfouche C.; Polito L.; Romano M. R.; Costantino P.; Berti F.; Adamo R.; Lay L. ACS Chem. Biol. 2013, 8, 2561-2567. [5] Berry DS.; Lynn F.; Lee C-H.; Frasch CE.; Bash MC. Effect of O-Acetylation of Neisseria Meningitis serogroup A capsular polysaccharide on development of functional immune responses, Infection and Immunity, 2002, 70(7), 3707-3713. [6] This project has received funding from the H2020-MSCA-ITN-2015 “Glycovax” under grant agreement No 675671.
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Lange, Karsten. "Carba-analoge Phospho- und Etherlipide enzymunterstützte Synthesen /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974084689.

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Jakob, Bernd. "Carba-analoge Glyceride und Phospholipide Synthesen und mechanische Studien /." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=957801998.

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Searle, Philip Adrian. "Synthesis of carba analogues of intermediates in the shikimate pathway." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293281.

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Lanot, Alisson Jamie Cruz. "Estudo de falhas transientes e técnicas de tolerância a falhas em conversores de dados do tipo SAR baseados em redistribuição de carga." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/114478.

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Conversores A/D do tipo aproximações sucessivas (SAR) baseados em redistribuição de carga são frequentemente utilizados em aplicações envolvendo a aquisição de sinais, principalmente as que exigem um baixo consumo de área e energia e boa velocidade de conversão. Esta topologia está presente em diversos dispositivos programáveis comerciais, como também em circuitos integrados de propósito geral. Tais dispositivos, quando expostos a ambientes suscetíveis a radiação, como é o caso de aplicações espaciais, estão sujeitos à colisão com partículas capazes de ionizar o silício. Estes podem causar falhas temporárias, como um efeito transiente, uma inversão de bit em um elemento de memória, ou até mesmo danos permanentes no circuito. Este trabalho visa descrever o comportamento do conversor SAR baseado em redistribuição de carga após a ocorrência de efeitos transientes causados por radiação, por meio de simulação SPICE. Tais efeitos podem causar falhas nos componentes da topologia: chaves, lógica de controle e comparador. Estes são propagados por todo o estágio de conversão, devido à sua característica sequencial de conversão. Por fim, uma discussão sobre as possíveis técnicas de mitigação de falhas para esta topologia é apresentada.
Successive Approximation Register (SAR) Analog to Digital Converters (ADCs) based on charge redistribution are frequently used in data acquisition systems, especially those requiring low power and low area, and good conversion speed. This topology is present on several mixed-signal programmable devices. These devices, when exposed to harsh environments, such as radiation, which is the case for space applications, are prone to Single Event Effects (SEEs). These effects may cause temporary failures, such as transient effects or memory upsets or even permanent failures on the circuit. This work presents the behavior of this type of converter after the occurrence of a transient fault on the circuit, by means of SPICE simulations. These transient faults may cause an inversion on the conversion due to a transient on the control logic of the switches, or a charge or discharge of the capacitors when a transient occur on the switches, as well as a failure on the comparator, which may propagate to the remainder stages of conversion, due to the sequential nature of the converter. A discussion about the possible fault mitigation techniques is also presented.
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Kuntz, Taimur Gibran Rabuske. "TÉCNICAS PARA REDUÇÃO DE CONSUMO EM CONVERSORES ANALÓGICO-DIGITAIS POR APROXIMAÇÃO SUCESSIVA E COMPARTILHAMENTO DE CARGA." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/5391.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico
New trends and emerging technologies motivate the design of analog-to-digital converters (ADCs) which must fit in increasingly constrained environments. Within this context, one design metric which is constantly forced towards reduction is the power consumption, leading the designers to come up with improvements in both the architecture and circuit levels. This work aims to push forward the energy efficiency of the successive approximation charge sharing ADC, which is a relatively new and unexplored architecture. Therefore, three complete ADCs are designed throughout this work, each one bringing novelties that help decreasing the power consumption. The techniques devised here include novel manners of dealing with the tracking of the input signal and a circuit to reduce power drained in the pre-charge cycle. Also, three different architectures of digital controller for this ADC topology are designed. Moreover, a novel bootstrapping switch circuit is presented, which provides lower devices-count and a extremely high energy efficiency.
As novas tendências e tecnologias emergentes motivam o projeto de conversores analógico-digitais (ADCs) que precisam suprir especificações cada vez mais restritivas. Nesse contexto, uma métrica de projeto que é constantemente forçada em direção à redução é o consumo de potência, fato esse que leva à concepção de melhorias tanto em nível arquitetural como em nível de circuito elétrico. Este trabalho tem como objetivo elevar a eficiência energética dos ADCs por aproximações sucessivas e compartilhamento de carga, visto que essa é uma arquitetura relativamente nova e inexplorada. Portanto, três ADCs completos são projetados ao longo deste trabalho, e cada um traz inovações que ajudam a reduzir o consumo de potência. As técnicas concebidas aqui incluem maneiras novas de efetuar a captura do sinal de entrada e um circuito para reduzir a potência drenada no ciclo de pré-carga. Além disso, três arquiteturas diferentes de controlador digital para essa topologia de ADC são expostas. Mais, um novo circuito de chave com bootstrapping é apresentado, o qual apresenta um número de dispositivos menor e uma eficiência energética extremamente alta.
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Costa, Luís Guilherme da Silva. "Circuitos de acoplamento para transceptores PLC (Power Line Communications)." Universidade Federal de Juiz de Fora (UFJF), 2012. https://repositorio.ufjf.br/jspui/handle/ufjf/4143.

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Atualmente, há um grande interesse no desenvolvimento de transceptores PLC (power line communication) para a transmissão banda larga e banda estreita de dados visando, sobretudo, aplicações smart grids e de acesso banda larga. Para o avanço da tecnologia PLC, há grande demanda pela introdução de acopladores com características e desempenhos que viabilizem a conexão dos tranceptores PLC `as redes de energia elétrica, com o mínimo de distorção possível. Neste contexto, a presente contribuição versa sobre o estudo, a investigação, especificação, projeto e análise de acopladores capacitados para transceptores PLC SISO (single input single output) banda larga e banda estreita. Para tanto, são introduzidos acopladores PLC nas seguintes faixas de frequências: de 9 kHz `a 2 MHz, de 1,7 MHz `a 100 MHz e de 1,7 MHz `a 150 MHz. As análises dos projetos e dos protótipos dos acopladores, concebidos para operar nas referidas bandas, mostram as dificuldades encontradas para garantir que as especificações de projeto sejam atendidas quando os componentes passivos são comerciais e a faixa de frequência de operação do acoplador aumenta. Além disso, as análises confirmam a necessidade de consideração de técnicas de prototipação de placas de circuitos impresso para sinais de frequência elevada. Finalmente, os resultados de medição mostram que os acopladores para baixa frequência discutidos podem ser utilizados em sistemas de medição de canais PLC.
Currently, there is a great interest to develop power line communications (PLC) transceivers for broadband and narrowband data communications for smart grids and network access. However, for advancing PLC technologies, there is a great demand for introduction of couplers for connecting the PLC tranceivers to the electric energy circuits with minimum distortion. This contribution addresses the study, investigation, specification, design, and analysis of capacitive couplers for single input single output (SISO), broadband and narrowband PLC transceivers. Capacity and SISO PLC couplers covering the following frequencies bandwidth are addressed: from 9 kHz up to 2 MHz, from 1,7 MHz up to 100 MHz and from 1,7 MHz up to 150 MHz. The analysis performance of the designed and prototyped PLC couplers for operating in the aforementioned frequencies bandwidths, shows the inherent difficulties to guarantee that the design specifications are fulfilled when passive components are commercial ones and the frequency bandwidth increase. Additionally, the analysis confirms the need for taking into account advancing prototyping techniques for dealing with high-frequency signals. Finally, the measurements show that the discussed narrowband PLC couplers can be used in a PLC channel system.
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Lange, Karsten [Verfasser]. "Carba-analoge Phospho- und Etherlipide : enzymunterstützte Synthesen / vorgelegt von Karsten Lange." 2004. http://d-nb.info/974084689/34.

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Jakob, Bernd [Verfasser]. "Carba-analoge Glyceride und Phospholipide : Synthesen und mechanische Studien / von Bernd Jakob." 1999. http://d-nb.info/957801998/34.

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Book chapters on the topic "Carba analogue"

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Hlavácek, J., R. Jezek, and R. Marcová. "Carba analogues of endothelin-I." In Peptides 1994, 295–96. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-1468-4_129.

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Lebl, M., I. Fric, E. E. Sugg, W. L. Cody, and V. J. Hruby. "CONFORMATIONAL STUDIES OF CARBA-ANALOGS OF OXYTOCIN." In Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986, edited by Dimitrios Theodoropoulos, 341–44. Berlin, Boston: De Gruyter, 1987. http://dx.doi.org/10.1515/9783110864243-078.

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Procházka, Zdenko, Jiřina Slaninová, Per Melin, Carl-Johan Aurell, and Michal Lebl. "The deamino carba analogs of [Phe2, Orn8]vasotocin." In Peptides 1992, 715–16. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_326.

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Neunert, Grazyna, Jolanta Tomaszewska-Gras, Aneta Baj, Marlena Gauza-Wlodarczyk, Stanislaw Witkowski, and Krzysztof Polewski. "Changes in DPPC Liposomes Structure Induced by a 1-Carba-Alpha-Tocopherol Analogue." In Current Topics on Chemistry and Biochemistry Vol. 2, 69–90. Book Publisher International (a part of SCIENCEDOMAIN International), 2022. http://dx.doi.org/10.9734/bpi/ctcb/v2/2259a.

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Ari, Yakup. "Continuous Autoregressive Moving Average Models." In Methodologies and Applications of Computational Statistics for Machine Intelligence, 118–41. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-7701-1.ch007.

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The financial time series have a high frequency and the difference between their observations is not regular. Therefore, continuous models can be used instead of discrete-time series models. The purpose of this chapter is to define Lévy-driven continuous autoregressive moving average (CARMA) models and their applications. The CARMA model is an explicit solution to stochastic differential equations, and also, it is analogue to the discrete ARMA models. In order to form a basis for CARMA processes, the structures of discrete-time processes models are examined. Then stochastic differential equations, Lévy processes, compound Poisson processes, and variance gamma processes are defined. Finally, the parameter estimation of CARMA(2,1) is discussed as an example. The most common method for the parameter estimation of the CARMA process is the pseudo maximum likelihood estimation (PMLE) method by mapping the ARMA coefficients to the corresponding estimates of the CARMA coefficients. Furthermore, a simulation study and a real data application are given as examples.
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Jux, N., F. P. Montforts, and E. Haake. "17.8.8 Contracted, Isomeric, and Expanded Porphyrins and Carba and Hetero Analogues (Update 2022)." In Knowledge Updates 2022/1. Stuttgart: Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/sos-sd-117-00706.

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Ogawa, Seiichiro, and Hidetoshi Tsunoda. "[9] Chemical synthesis of glycosylamide and cerebroside analogs composed of carba sugars." In Methods in Enzymology, 136–43. Elsevier, 1994. http://dx.doi.org/10.1016/s0076-6879(94)47011-1.

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Schobert, R., and G. J. Gordon. "Five- and Six-Membered Carbo- and Heterocycles from Cumulated Ylides and Carbonyl Compounds Bearing Acidic Functional Groups." In Heteroatom Analogues of Aldehydes and Ketones, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00916.

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Conference papers on the topic "Carba analogue"

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Hocek, Michal. "Synthesis of carba-analogues of myoseverin." In XIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2002. http://dx.doi.org/10.1135/css200205324.

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Hřebabecký, Hubert. "Synthesis of carba analogues of 2'-deoxy-4'-C-(hydroxymethyl)nucleosides." In XIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902266.

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Трофимов, Б., B. Trofimov, Н. Гусарова, and N. Gusarova. "The development of original methodologies of directed synthesis of le-Carbs their analogs and precursors base donacetylene and its derivatives." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. Москва: INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec92d17.

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New reactions, which have been discovered and continue to be developed in A.E. Favorsky Irkutsk institute of chemistry SB RAS on the basis of acetylene, a product of oil, gas and coal processing and multi-faceted building block for organic synthesis, have been considered. These reactions provide for the shortest routes to construction of fundamental heterocyclic scaffolds (pyrroles, imidazoles, pyrazoles, indoles, pyridines, dihydropyridines, etc.) with desirable and optimum combination of functional pharmacophoric groups and fragments, which are responsible for antiviral (HIV, flu), antitumor, tuberculostatic and hypotensive activities.
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