Relevant bibliographies by topics / Capsaicin

Academic literature on the topic 'Capsaicin'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 March 2023

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Journal articles on the topic "Capsaicin"

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Bergren, D. R. "Capsaicin challenge, reflex bronchoconstriction, and local action of substance P." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 254, no. 5 (May 1, 1988): R845—R852. http://dx.doi.org/10.1152/ajpregu.1988.254.5.r845.

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Capsaicin was administered as an aerosol to unanesthetized guinea pigs in a whole body plethysmograph and intravenously to anesthetized guinea pigs to investigate its mechanism of action. Capsaicin increased specific airway resistance in the unanesthetized guinea pigs and increased insufflation pressure in anesthetized guinea pigs. To investigate the possible reflex action of capsaicin, an atropine or lidocaine aerosol was administered before the capsaicin aerosol challenge in unanesthetized guinea pigs. Both lidocaine and atropine reduced the effect of capsaicin. However, neither intravenous atropine nor bilateral vagotomy antagonized the effect of injected capsaicin in the anesthetized guinea pigs. To investigate further the possible action of capsaicin, spantide (a substance P receptor antagonist) was administered before capsaicin challenge. Spantide injection in anesthetized guinea pigs attenuated the effects of the intravenous capsaicin challenge. In unanesthetized guinea pigs spantide pretreatment, as an aerosol, did not ameliorate the effects of a capsaicin aerosol challenge. However, intraperitoneal administration of spantide did reduce the effect of the capsaicin aerosol challenge as the specific airway resistance increased. Therefore, capsaicin produced its effects independent of vagal reflexes, although reflex actions of capsaicin could have occurred through other pathways. Reflex actions of capsaicin, however, were demonstrable only in the unanesthetized guinea pig. Because spantide attenuated the effect of capsaicin, increased insufflation pressure and specific airway resistance due to capsaicin challenge in both unanesthetized and anesthetized guinea pigs may be attributed, at least in part, to capsaicin's induction of substance P release or the release of other tachykinins.
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Mardhiana, Febby, Sigit Soeparjono, and Tri Handoyo. "Pengaruh Konsentrasi dan Waktu Aplikasi (NaCl) Terhadap Hasil dan Mutu Cabai Merah (Capsicum annum L.)." Agriprima, Journal of Applied Agricultural Sciences 2, no. 1 (March 24, 2018): 1–8. http://dx.doi.org/10.25047/agriprima.v2i1.81.

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Cabai (Capsicum annum L.) merupakan tanaman penting di Indonesia. Dalam 100 gram cabai segar mengandung sekitar 0,1-1,5% capsaicin yang merupakan tingkat kualitas cabai. Salah satu faktor yang mempengaruhi kadar capsaicin adalah kondisi stres salinitas. Kami mengamati efek salinitas dan waktu aplikasi pada hasil dan kandungan capsaisin. Tujuan dari penelitian ini adalah untuk mengetahui respon tanaman cabai dengan penambahan konsentrasi dan waktu aplikasi NaCl terhadap cabai dan kualitas. Penambahan konsentrasi NaCl sampai 9000 ppm dan waktu penerapan fase vegetatif NaCl dapat meningkatkan variabel kualitas kadar capsaicin dibandingkan dengan perlakuan kontrol.
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Al-Samydai, Ali, Walhan Alshaer, Emad A. S. Al-Dujaili, Hanan Azzam, and Talal Aburjai. "Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes." Nutrients 13, no. 11 (November 10, 2021): 3995. http://dx.doi.org/10.3390/nu13113995.

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Background: Medicinal plants have proven their value as a source of molecules with therapeutic potential, and recent studies have shown that capsaicin has profound anticancer effects in several types of human cancers. However, its clinical use is handicapped due to its poor pharmacokinetics. This study aims to enhance capsaicin’s pharmacokinetic properties by loading the molecule into nanoliposomes model and testing its anticancer activity. Methods: Nanoliposomes were prepared using the thin-film method, and characteristics were examined followed by qualitative and quantitative analyses of encapsulation efficiency and drug loading using HPLC at different lipid/capsaicin ratios. Cell viability assay (MTT) was used to determine IC50. Results: Capsaicin-loaded nanoliposomes showed optimum characteristics of morphology, particle size, zeta potential, and stability. In vitro anticancer activity of capsaicin and capsaicin-loaded nanoliposomes were compared against MCF7, MDA-MB-231, K562, PANC1, and A375 cell lines. Capsaicin-loaded nanoliposomes showed significant improvement in anticancer activity against cancers cell lines studied (p < 0.001), with increased selectivity against cancer cells compared to capsaicin. Conclusion: The encapsulated capsaicin nanoliposomes produced an improvement in pharmacokinetics properties, enhancing the anticancer activity and selectivity compared with capsaicin. This model seems to offer a potential for developing capsaicin formulations for the prevention and treatment of cancer.
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M, Djaldetti. "Capsaicin as a Cancer Chemopreventer- The Two Sides of the Same Coin." Gastroenterology & Hepatology International Journal 7, no. 2 (August 30, 2022): 1–13. http://dx.doi.org/10.23880/ghij-16000197.

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The pungent component of the chili pepper known as capsaicin is popular both as a spice and as a carcinopreventer. In vitro experiments and studies with animal models suggest that capsaicin may inhibit gastrointestinal, pancreatic, hepatic and other sorts of cancer development through a number of different pathways. Additionally, capsaicin may improve the therapeutic potential of traditional anti-cancer medications when taken with them. However, several reports have raised concerns that capsaicin may have a dual impact on cancer cells that promotes both cell proliferation and metastatic abilities. The purpose of this review is to examine the contradicting information regarding capsaicin’s ability to prevent cancer.
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Mizogami, Maki, and Hironori Tsuchiya. "Membrane Interactivity of Capsaicin Antagonized by Capsazepine." International Journal of Molecular Sciences 23, no. 7 (April 2, 2022): 3971. http://dx.doi.org/10.3390/ijms23073971.

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Although the pharmacological activity of capsaicin has been explained by its specific binding to transient receptor potential vanilloid type 1, the amphiphilic structure of capsaicin may enable it to act on lipid bilayers. From a mechanistic point of view, we investigated whether capsaicin and its antagonist capsazepine interact with biomimetic membranes, and how capsazepine influences the membrane effect of capsaicin. Liposomal phospholipid membranes and neuro-mimetic membranes were prepared with 1,2-dipalmitoylphosphatidylcholine and with 1-palmitoyl-2-oleoylphosphatidylcholine and sphingomyelin plus cholesterol, respectively. These membrane preparations were subjected to reactions with capsaicin and capsazepine at 0.5–250 μM, followed by measuring fluorescence polarization to determine the membrane interactivity to modify the fluidity of membranes. Both compounds acted on 1,2-dipalmitoylphosphatidylcholine bilayers and changed membrane fluidity. Capsaicin concentration-dependently interacted with neuro-mimetic membranes to increase their fluidity at low micromolar concentrations, whereas capsazepine inversely decreased the membrane fluidity. When used in combination, capsazepine inhibited the effect of capsaicin on neuro-mimetic membranes. In addition to the direct action on transmembrane ion channels, capsaicin and capsazepine share membrane interactivity, but capsazepine is likely to competitively antagonize capsaicin’s interaction with neuro-mimetic membranes at pharmacokinetically-relevant concentrations. The structure-specific membrane interactivity may be partly responsible for the analgesic effect of capsaicin.
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Kalil, Haitham, Cynthia Crichlow, and Mekki Bayachou. "Peroxynitrite Reactivity with Capsaicin: A Potential for Capsaicin-Based Sensing Devices." ECS Meeting Abstracts MA2022-02, no. 53 (October 9, 2022): 2586. http://dx.doi.org/10.1149/ma2022-02532586mtgabs.

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Peroxynitrite and other reactive oxygen species (ROS) have been linked to illnesses caused by oxidative stress, such as atherosclerosis. Accurate detection of these species in biological systems is crucial not only for understanding the etiology and course of the disease but also for creating and evaluating viable therapies. In the last 30 years, there has been an exponential increase in research into capsaicin's biological relevance. Capsaicin has analgesic, antioxidant, anti-inflammatory, anti-cancer, and anti-obesity properties. Most of these investigations have focused on the analgesic, antioxidant, and anticancer properties of this chemical compound throughout the last three decades. Capsaicin has been shown to increase the production of peroxynitrite by boosting the formation of superoxide anions in combination with nitric oxide. Preliminary UV-Vis results suggested a potential interaction at micromolar levels between capsaicin and peroxynitrite. A hyperchromic shift has been shown at a wavelength of ~ 300 nm, indicating an interaction between capsaicin and peroxynitrite, which resulted in a 2x increase in absorbance. The interaction of capsaicin and peroxynitrite was further studied using cyclic voltammetry and differential pulse voltammetry.
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Balleza-Tapia, Hugo, Pablo Dolz-Gaiton, Yuniesky Andrade-Talavera, and André Fisahn. "Capsaicin-Induced Impairment of Functional Network Dynamics in Mouse Hippocampus via a TrpV1 Receptor-Independent Pathway: Putative Involvement of Na+/K+-ATPase." Molecular Neurobiology 57, no. 2 (November 7, 2019): 1170–85. http://dx.doi.org/10.1007/s12035-019-01779-3.

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Abstract The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1). A growing number of studies use capsaicin as a tool to study the role of TrpV1 in the central nervous system (CNS). Although most of capsaicin’s CNS effects have been reported to be mediated by TrpV1 activation, evidence exists that capsaicin can also trigger functional changes in hippocampal activity independently of TrpV1. Recently, we have reported that capsaicin induces impairment in hippocampal gamma oscillations via a TrpV1-independent pathway. Here, we dissect the underlying mechanisms of capsaicin-induced alterations to functional network dynamics. We found that capsaicin induces a reduction in action potential (AP) firing rate and a subsequent loss of synchronicity in pyramidal cell (PC) spiking activity in hippocampus. Moreover, capsaicin induces alterations in PC spike-timing since increased first-spike latency was observed after capsaicin treatment. First-spike latency can be regulated by the voltage-dependent potassium current D (ID) or Na+/K+-ATPase. Selective inhibition of ID via low 4-AP concentration and Na+/K+-ATPase using its blocker ouabain, we found that capsaicin effects on AP spike timing were completely inhibited by ouabain but not with 4-AP. In conclusion, our study shows that capsaicin in a TrpV1-independent manner and possibly involving Na+/K+-ATPase activity can impair cognition-relevant functional network dynamics such as gamma oscillations and provides important data regarding the use of capsaicin as a tool to study TrpV1 function in the CNS.
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Rohmah, Mahya Nur, Suyadi Mitrowihardjo, and Rudi Hari Murti. "Yield, Capsaicin Content and Peroxidase Enzyme Activity of Four Chili Cultivars on Three Environments." Ilmu Pertanian (Agricultural Science) 1, no. 2 (August 17, 2017): 055. http://dx.doi.org/10.22146/ipas.11786.

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The experiment aimed to determine the effect of different environment (altitude and drought stress) on the growth, yield per plants, capsaisin levels, and peroxidase activities of four chili cultivars. Capsicum annuum (‘Lado’ and ‘Gada’) and Capsicum frutescens (‘Pelita’ and ‘Sona’) were grown with standard cultivation in medium land (± 700 m asl, Kaliurang) and low land (112 m asl, Bulaksumur) in two environments i.e. standard cultivation and drought treatment. The cultivars were arranged in Complete Randomize Design with four replications in each environment. The data were analyzed using analysis of variance with orthogonal contrast model, while the GGE biplot was applied for identification of stability. The result showed significant interaction between environment and cultivar on plant height, fruit’s weight per plant and the contents of capsaicin. Medium land of Kaliurang had suitable environment for chili cultivation of four cultivars and the high capsaicin content of C. frutescens. ‘Gada’ was significantly higher than other cultivars for fruit weight per plant in all planting conditions, while ‘Sona’ had the highest capsaicin content and was stable in all environments. Drought stress increased capsaicin content in low capsaicin content variety, in contrast to high capsaicin content cultivar. Peroxidase enzyme activity of C. frutescens was significantly higher than C. annuum, while C. annuum cultivars also shown significantly different in peroxidase activity.
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Bhutani, M., A. K. Pathak, G. Sethi, and B. B. Aggarwal. "Capsaicin induces G1/S cell cycle arrest leading to apoptosis of multiple myeloma cells through suppression of STAT3 activation and STAT3-regulated gene products." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 20039. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20039.

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20039 Background: Agents that can block activated STAT3, a central player for proliferation, cell survival and chemoresistance, have a potential as therapeutic agents for the treatment of Multiple Myeloma (MM). Capsaicin, a spicy component of hot pepper, is a homovanillic acid derivative that preferentially induces certain cancer cells to undergo apoptosis. We have previously shown that Capsaicin blocked activation of NF-kappa B in human myeloid ML-1a cells. In this study we evaluated the effect of Capsaicin on STAT3 in MM cells. Methods: We used U266, a well-characterized MM cell line, which constitutively expresses activated STAT3. MM cells treated with Capsaicin were subjected to western blot analysis with specific antibodies to STAT3, tyrosyl phosphorylated STAT3 and STAT5. The effect of Capsaicin on nuclear-cytoplasmic compartment of STAT3 was studied by immunocytochemistry. The antiproliferative effect of Capsaicin was determined by the MTT assay and the effect on the cell cycle was determined by flowcytometry. Apoptosis of cells was measured using the Live and Dead assay. To determine the downstream targets like antiapoptotic proteins (Bcl-xL, Bcl-2, and Survivin), and cell cycle-regulators (cyclin D1) immunoblot analysis of Capsaicin treated cells was performed. Results: Capsaicin suppressed the constitutive activation of STAT3 in human MM cells in a dose- and time-dependent manner, prior to cell death. Capsaicin’s effect on STAT3 was specific as STAT5 was unaffected. Capsaicin depleted nuclear pool of STAT3 in U266 cells. Abrogation of constitutive STAT3 phosphorylation in MM cells induced G1 cell cycle arrest. The antiapoptotic proteins BCl-xl, suvivin, cyclin D1, and Bcl-2, which are encoded in target genes of STAT3, were down regulated by Capsaicin, followed by induction of apoptosis through activation of caspase-3. We further demonstrated that low dose combined Capsaicin and thalidomide/ bortezomib treatment triggered synergistic cytotoxicity. Conclusions: These findings suggest that the antitumor activity of Capsaicin is at least partially due to inhibition of STAT3 pathway and provide a basis for potential application of Capsaicin for treatment of relapsed and refractory MM. No significant financial relationships to disclose.
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Kwon, Youngjoo. "Estimation of Dietary Capsaicinoid Exposure in Korea and Assessment of Its Health Effects." Nutrients 13, no. 7 (July 19, 2021): 2461. http://dx.doi.org/10.3390/nu13072461.

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The consumption of capsaicinoids, the active components in chili peppers, has been associated with both positive and negative health effects, and the level of capsaicinoid exposure may be an important determinant. Dietary capsaicinoid exposure was estimated using a previously developed database for capsaicinoid content and a 24-h dietary recall dataset obtained from the Korea National Health and Nutrition Examination Survey. The estimated consumption level was evaluated to determine its potential effects on weight reduction and gastrointestinal distress. The estimated daily mean capsaicinoid intake was 3.25 mg (2.17 mg capsaicin), and most Koreans consumed 1–30 mg of capsaicinoids (0.67–20 mg capsaicin) in a day. No adverse effect of capsaicin consumption was reported other than abdominal pain. For long-term repeated consumption, 30 mg may be the maximum tolerable dose. However, the effects on body weight or energy balance were inconsistent in 4–12 week clinical studies conducted with various capsaicin doses (2–135 mg), which was likely due to the complex interplay between capsaicin dose, study length, and participant characteristics. Therefore, the capsaicin consumption of most Koreans was below the levels that may cause adverse effects. However, more long-term studies for the dose range of 2–20 mg are required to further characterize capsaicin’s health benefits in Koreans.
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Dissertations / Theses on the topic "Capsaicin"

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Cedrón, Juan Carlos. "Capsaicin." Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/99655.

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Pica, nos hace ponernos rojos, pero también alivia el dolor. La capsaicina es el componente principal del ají, ingrediente de tantas comidas en nuestro país.
It is spicy, it makes us blush, but it also relieves pain. Capsaicin is the main component of chili pepper, an ingredient in so many dishes in our country.
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Hughes, G. A. "Novel, potent antagonists of capsaicin." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445556/.

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The aim of this project was to explore and refine the conformational rationale for the activity of capsazepine (CPZ) as a blocker of the ion channel TRPV1 (transient receptor potential vanilloid type 1), by the synthesis and biological evaluation of further conformational constrained capsaicin analogues. The resolution of the stereoisomers of Af-(4-chlorophenethylthiocarbamoyl)-6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquino-line 29, Af-(4-chlorophenethylthio-carbamoyl)-6,7-dihydroxy-3-methyl-1,2,3,4-tetra-hydroisoquinoline 30 and N-(4-chlorophenethylthiocarbamoyl)-6,7-dihydroxy-1,3-dimethyl-1,2,3,4-tetrahydroiso-quinoline 31 by stereoselective synthetic methodology is described, and some of the more unusual and interesting mechanisms are discussed. The novel asyrnmetric chemistry described includes the separation of the enantiomers of 2-(3,4-dimethoxyphenyl)-l-methylethylamine 38 by crystallisation with the enantiomers of mandelic acid, the use of sodium triacetoxyborohydride in the stereoselective reduction of 6,7-dimethoxy-l,3-dimethyl-3,4-dihydroiso-quinoline 171, to give the cw-diastereomers of 6,7-dimethoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline 44, and the novel stereoselective route to the trans-diastereomers of 6,7-dimethoxy-l,3-dimethyl-l,2,3,4-tetrahydroisoquinoline 44 from the enantiomers of 2-(3,4-dimethoxyphenyl)-l-methylethylamine 38 by the Michael addition of A-benzyl-2-(3,4-dimethoxyphenyl)-l-methylethylamine 155 to ethynyl-4-tolylsulfone 150, followed by TFA-mediated cyclisation, single electron reductive desulfonylation and palladium-catalysed hydrogenolysis. The results of investigations into the conformational behaviour of the resolved stereoisomers of 29, 30 and 31 by techniques of NMR spectroscopy and molecular modelling, the evaluation of their biological activity at the rat and human orthologues of the ion channel TRPV1, and the attempted correlation of the two sets of data, with respect to the published conformational rationale for the activity of CPZ, are also described.
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Ziglio, Analine Crespo. "Uso da capsaicina como preservante de madeiras ao ataque de fungo apodrecedor." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/88/88131/tde-16082010-143912/.

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Nesse estudo, utilizamos a oleoresina de capsaicina, extraído da pimenta Malagueta (Capsicum frutensens) e da pimenta Dedo-de-moça (Capsicum baccatum), para a preservação de amostras de madeira contra o ataque do fungo Paecilomyces variotti. Os preservantes naturais foram aplicados em corpos de prova de madeiras do gênero Pinus sp. e Hymenae sp. (Jatobá) com as dimensões 5,0 x 3,0 x 1,0 (cm). A seguir, esses corpos de prova foram expostos ao fungo para o acompanhamento do seu desenvolvimento. As análises mostraram que o preservante natural retardou o crescimento do fungo, sendo a oleoresina de capsaicina extraído da pimenta Malagueta a mais eficiente se comparada à oleoresina extraída da pimenta Dedo-de-moça e ao óleo de linhaça. A partir da medida de ângulo de contato observou-se que o preservante de oleoresina da pimenta Malagueta proporcionava uma maior molhabilidade para as duas espécies de madeiras. A técnica de FTIR-ATR indicou que os preservantes não modificaram a estrutura das madeiras e a análise de raios X revelou que o desenvolvimento do fungo provocou uma perda de estabilidade e periodicidade nas estruturas das madeiras. Através do teste de proporção utilizado para a análise do desenvolvimento do fungo, comprovou-se estatisticamente que o seu crescimento foi menor para as amostras com os preservantes das pimentas. Pelo MEV foi possível visualizar as estrutura de hifas do fungo sobre a madeira. E a perda de massa para ambas as espécies de madeiras foram menores quando foram utilizados os preservantes, sendo o Pinus a espécie que sofreu maior degradação.
In this study, were used the oleoresin capsaicin, extracted from Capsicum frutensens and Capsicum baccatum, for the preservation of wood samples against the attack of the Paecilomyces variotti fungus. The natural preservatives were applied to Pinus sp. and Hymenaea sp. (Jatobá) specimens with the dimensions 5.0 x 3.0 x 1.0 (cm). Subsequently, these specimens were exposed to fungus and their development was monitored. . Analyses showed that the natural preservative slowed the growth of the fungus. Action of the oleoresin capsaicin extracted from Chilli pepper is the most efficient when compared to pepper oleoresin extracted from Capsicum frutensens and Capsicum baccatum and also with the linseed oil. The contact angle measured showed that the preservative of Oleoresin Chilli Pepper offered a higher wettability for both wood species. FTIR-ATR technique indicated that the preservatives did not change wood structure and X-ray analysis revealed that the development of the fungus caused a loss of stability and periodicity in the wood structures. At proportion test to analyze the development of the fungus, it was shown statistically that their growth was lower for the samples with preservatives peppers. It was possible to visualize the hyphae structure by scanning electronic microscopy technique. Mass loss of both wood specie was lower when preservative was used, and Pine species was more degraded.
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Tablas, Mariana Baptista. "Efeitos da capsaicina na etapa de promoção/progressão da carcinogênese química de colón em ratos." Botucatu, 2018. http://hdl.handle.net/11449/180429.

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Orientador: Luís Fernando Barbisan
Resumo: A capsaicina (8-metil-N-vanilil-trans-6-nonamida) é uma substância alcaloide de natureza lipofílica, responsável pela pungência de pimentas e pimentões. Apresenta propriedades anti-inflamatória, antimicrobiana e antioxidante bem descritas na literatura científica. Assim, este projeto teve como objetivo investigar se a capsaicina apresenta efeito quimioprotetor quando administrada na etapa de promoção/progressão da carcinogênese de cólon induzida pela 1,2-dimetilhidrazina (DMH). Ratos Wistar machos foram alocados em seis grupos experimentais com 10 a 15 animais cada. Os animais dos grupos 1-3 receberam quatro injeções subcutâneas (s.c) do carcinógeno DMH (40mg/kg, duas doses/semana) e os animais do grupo 4-6 receberam quatro injeções s.c de solução de EDTA .Os grupos 2 e 4 receberam por gavagem 5mg/kg p.c e os grupos 3 e 5 receberam 50mg/kg p.c de capsaicina diluída em óleo de milho até o final da 24ª semana do experimento. Após a eutanásia dos animais, os cólons distal, medial e proximal foram corados com azul de metileno a 2% para detecção de focos de criptas aberrantes (FCA). Após a análise de FCAs, os cólons foram processados para análise histológica e classificação de tumores. As amostras congeladas foram utilizadas para análise de expressão de gênica pela técnica Taqman® Low Density Array (TLDA). Os níveis séricos de ALT (p=0,346) e creatinina (p=0,854) foram semelhantes entre os grupos, mostrando que as doses de capsaicina utilizadas não apresentaram ação citotóxica par... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Capsaicin (8-Methyl-N-vanillyl-(trans)-6-nonenamide) is a lipophilic alkaloid, responsible for the pungency in pepper. Its antiinflamatory, antimicrobial and antioxidant properties are well described in the scientific literature. Thus, the objective of this study was to investigate whether capsaicin exerts a chemoprotective effect when administered during 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis promotion/progression in rates. Male Wistar rats were allocated into six groups of 10-15 animals each. Groups 1-3 received 4 subcutaneous injections of DMH (40 mg/kg bw, 2 doses/week), while groups 4-6 received EDTA solution (DMH vehicle, 2 doses/week), followed by intragastric 5mg/kg bw capsaicin diluted in corn oil (G2, G4) or 50mg/kg bw (G3, G5) for 24 weeks (3 doses/week). After sacrifice, blood samples were drawn by heart puncture for the assessment of serum alanine aminotransferase (ALT) and creatinine levels, and the colon was removed. A segment of distal colon and colon tumor samples were frozen in liquid nitrogen at -80ºC. Distal, medial and proximal colon samples were stained with 2% methylene blue for the detection of aberrant crypt foci (ACF).After ACF analysis, colon tumors were processed for histological analysis and tumor classification. The frozen samples were used for the analysis of gene expression by Taqman® Low Density Array (TLDA). Serum ALT (p=0.346) and creatinine (p=0.854) levels were similar among groups, indicating that the capsaicin doses use... (Complete abstract click electronic access below)
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Ziglio, Analine Crespo. "Oleoresina de capsaicina como preservante natural de madeira de Pinus sp. contra a ação de fungos de podridão branca e de podridão mole." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/18/18158/tde-27082015-101533/.

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Neste trabalho, avaliou-se a eficácia do uso da oleoresina de capsaicina, extraído das pimentas Malagueta, Red Savina e Bhut Jolokia, no tratamento da superfície de madeiras do gênero Pinus sp. com teores de umidade de equilíbrio de 12% e 0%. Os corpos de prova foram submetidos ao ataque de fungos Paecilomyces variotti e Pycnoporus sanguineus. Foi utilizado um preservante sintético conhecido comercialmente como stain para se comparar com a eficiência de preservantes naturais à base de oleoresina de capsaicina. A partir de medidas de ângulo de contato das superfícies das madeiras tratadas com o óleo de capsaicina, observou-se que a pimenta Bhut Jolokia e o preservante stain proporcionavam menor molhabilidade para a espécie de madeira estudada em ambos teores de umidade. O tratamento preservante fez com que a energia de superfície diminuísse se comparada aos valores de amostras de madeiras sem o tratamento preservante devido às contribuições polares e dispersivas. A análise estatística dos resultados, pelo método de Tukey, mostrou que não existe um grupo de resultados estatisticamente equivalente aos obtidos com a amostra testemunha (sem tratamento). As amostras de Pinus sp. a um teor de umidade 0% mostrou-se mais protegida superficialmente quando modificada com a oleoresina extraída da pimenta Bhut Jolokia e o mesmo efeito foi observado estatisticamente para o preservante stain. A técnica de Langmuir foi utilizada para melhor compreender as interações capsaicina/ergosterol, capsaicina/DPPG (dipalmitoil fosfatidil glicerol) e capsaicina/DPPG/ergosterol. A isotermas de pressão de superfície vs área por molécula se mostraram mais expandidas quando a subfase continha oleoresina de capsacina e quando comparada com as de lipídio puro (DPPG), indicando assim, a inserção da capsaicina na monocamada. Em linhas gerais, oleoresina de capsaicina extraída da pimenta Bhut Jolokia mostrou-se mais eficiente em todos os aspectos se comparada com as pimentas Red Savina e Malagueta, marcando, assim, uma potencialidade para uso como preservante natural de madeiras.
The present study evaluated the effectiveness of capsaicin oleoresin extracted from Malagueta, Red Savina and Bhut Jolokia peppers in the surface treatment of Pinus sp. with moisture contents of 12% and 0%. The samples were submitted to the attack of Paecilomyces variotti and Pycnoporus sanguineus fungus. A synthetic wood preservative, that is commercially known as stain, was used to compare the effectiveness of natural preservatives based on capsaicin oleoresin. From contact angle measurements for wood surfaces treated with capsaicin oleoresin, it was obtained that Bhut Jolokia pepper and stain preservatives have provided worse wettability for wood samples at both moisture contents. The preservative treatment caused a decrease in the surface energy when compared to the samples without preservative treatment due to polar and dispersive contributions. Statistical analysis for the results by using the Tukey method showed that there is not a group of results that are statistically equivalent to those obtained for the control samples (without treatment). Pinus sp. samples at a moisture content of 0% showed to be more surface protected after being modified with the oleoresin extracted from Bhut Jolokia; the same effect was observed statistically for stain. The Langmuir technique was used to better understand interactions among capsaicin/ergosterol, capsaicin/DPPG (dipalmitoyl phosphatidyl glycerol) and capsaicin/DPPG/ergosterol. Surface pressure vs. area per molecule isotherms appeared to be even more extended when the subphase contained capsaicin oleoresin instead of pure lipid (DPPG), thus indicating the inclusion of capsaicin into the monolayer. In general, the capsaicin oleoresin extracted from Bhut Jolokia proved to be more efficient in all the aspects of characterization when compared to Red Savina and Malagueta highlighting its potential for use as a natural wood preservative.
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Bhatta, Puspanjali. "Protective effect of capsaicin against cisplatin ototoxicity." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1579.

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Cisplatin is a widely used chemotherapeutic drug for the treatment of solid tumors. However, the drug accumulates in the cochlea, and damages inner ear structures, resulting in bilateral andpermanent hearing loss. Previous data from our laboratory indicate that activation of the transient receptor potential vanilloid 1 (TRPV1) receptor (by capsaicin) increases the NOX3 isoform of NADPH oxidase, leading to the generation of reactive oxygen species (ROS) in the cochlea, transient cochlear inflammation and transient hearing loss. We also demonstrated that the transient inflammation was produced by ROS-mediated activation of signal transducer and activator of transcription 1 (STAT1). Surprisingly, over time, this response desensitizes and capsaicin was subsequently able to protect against cisplatin ototoxicity. The goal of this study was to determine the mechanism of otoprotection against cisplatin ototoxicity following the administration of capsaicin. For this study we utilize both an immortalized organ of Corti outer hair cells and rat cochlea. Capsaicin (2.5 µM) increased both Ser727 p-STAT1 and Tyr705 p-STAT3 implicating its role in inflammation. Expression of cannabinoid receptors were observed in UB/OC-1 cells as well as rat outer hair cells (OHCs). However, inhibition of CB2 receptors (by AM630) reduced capsaicin-mediated Tyr705 p-STAT3, but had little effect on Ser727 STAT1. Capsaicin protected UB/OC-1 cells against cisplatin-induced apoptosis. This protection was reversed by CB2 antagonist but potentiated by TRPV1 inhibition. Significant cell death was observed following treatment of UB/OC-1 cells with AM630 alone, underscoring the importance of CB2 receptors in survival of these cells. CB2 agonist, JWH, significantly increased the protective signal, STAT3. Furthermore, capsaicin-mediated protection was reversed by the inhibition of STAT3, implicating STAT3 in otoprotection. In animal studies, oral administration of capsaicin (0.5% solution) induced transient inflammation but led to a long term recovery. Animals pre-treated with oral capsaicin were protected against cisplatin-induced hearing loss as compared to vehicle-treated animals, suggesting protection against hearing loss. Capsaicin increased the expression of both CB1 and CB2 receptors in the organ of Corti, which might confer the long term protective actions of this agent against hearing loss. In rats pretreated with AM630, the protective action of capsaicin was abolished. We conclude that otoprotection mediated by capsaicin is produced by activation of CB receptors in the cochlea which are coupled to both STAT1 and STAT3 activation. However, our data support the conclusion that activation of STAT3 confers the otoprotective action of capsaicin. In contrast, activation of STAT1 by capsaicin could contribute to the transient inflammatory response previously observed in vivo. The net protective action of capsaicin could result from an increase in the STAT3/STAT1 ratio of cells in the cochlea, which antagonizes the ability of cisplatin lower this ratio and promote cell death.
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Saffran, Alexander. "Activation of TRPV1 by Capsaicin Regulates ENaC." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5544.

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ENaC is a constitutively open heterotrimeric channel which regulates Na+ transport in tight epithelia of the kidney, lungs, colon and anterior tongue containing fungiform taste buds. The amiloride-sensitive ENaC is comprised of aβg subunits. Humans express an additional subunit, the d subunit. Therefore, humans contain both aβg-ENaC and dβg-ENaC functional channels. Relative to aβg-ENaC, the dβg-ENaC is 10-fold less sensitive to amiloride. In the mammalian anterior tongue, ENaC is expressed in fungiform salt sensing taste receptor cells and is the Na+-specific salt taste receptor. In mammals, salt elicits an inverted U shaped behavioral response. Lower concentrations of salt are appetitive while high salt concentrations are aversive. The appetitive salt concentrations are sensed via ENaC. Thus, modulating ENaC activity in fungiform taste receptor cells will, in turn, regulate salt intake. The aim of this project is to investigate the effect of a common food ingredient, capsaicin, on ENaC expression and function in two cell lines, HEK293 cells and cultured adult human fungiform taste bud cells (HBO cells). Capsaicin, a TRPV1 agonist was chosen because in previous studies, it modulated chorda tympani taste nerve responses to NaCl in a dose-dependent manner. Most importantly, capsaicin and other agonists of TRPV1 were effective in modulating human salt taste perception. It is likely that the effect of capsaicin is due to its interactions with TRPV1, because TRPV1 and ENaC subunits are co-expressed in cortical collecting duct cells (CCD) and in a subset of human taste bud cells. In support of this hypothesis, TRPV1 has been shown to regulate ENaC expression and function in CCD cells of rats and mice. Using immunohistochemical techniques, our results demonstrate that TRPV1 is co-localized with the d-ENaC subunit in HBO cells. Additionally, the results in HEK-293 cells suggest that the activation of TRPV1 via capsaicin has a modulatory effect on d-ENaC mRNA and protein expression as well ENaC channel function measured as Na+ flux.
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8

Liapi, Anastasia. "Cloning of the vanilloid-like receptor VR-L and investigation of its interaction with members of the transient receptor potential family of receptors." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270624.

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Tavares, Mauricio Temotheo. "Candidatos a novos agentes antineoplásicos: síntese e avaliação da atividade antitumoral de análogos sulfonatos e sulfonamídicos da capsaicina." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-29102014-153643/.

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O câncer é o segundo grupo de doenças que mais mata em todo o mundo, atrás apenas das doenças cardiovasculares. No Brasil, esse panorama é preocupante devido ao período de acentuada tendência de envelhecimento, fase etária de maior incidência do câncer. Neste contexto, a atual terapia antineoplásica continua apresentando diversos vieses quanto à toxicidade e seletividade. Muitos dos fármacos empregados na clínica médica são de origem natural, ou tiveram em suas etapas iniciais de desenvolvimento, correlação com produtos naturais, enaltecendo a importância de fontes naturais no desenvolvimento de novos compostos bioativos. A capsaicina, substância responsável pela pungência apresentada pelos frutos de pimenteiras do gênero Capsicum, tem se mostrado um importante agente natural com atividade citotóxica à diversas linhagens neoplásicas, porém, sua ação pungente e baixa estabilidade físico-química, limitam seu emprego terapêutico. Com isso, a capsaicina apresenta grande potencial em servir como arcabouço para o planejamento de novas entidades químicas bioativas, análogas à mesma, para emprego no tratamento do câncer. Este trabalho propôs-se a planejar e sintetizar análogos sulfonamídicos e sulfonatos da capsaicina, promovendo variações moleculares no núcleo estrutural capsaicinóide. Após síntese em única etapa, os análogos foram obtidos e caracterizados por faixa de fusão, RMN 1H/13C e análise elementar. Posteriormente os compostos foram submetidos a ensaio de citotoxicidade nas linhagens tumorais: MDA-MB-231 e MCF-7 (de câncer de mama), B16-F10 (melanoma murino) e sobre linhagens sadias de fibroblasto (3T3), pelo método de avaliação da viabilidade celular por biorredução do sal de tetrazólio, o MTT. Quatro compostos apresentaram atividade biológica interessante, em concentrações micromolares (µM) iferiores à atividade apresentada pela capsaicina, destacando-se os compostos RPF-101 e RPF-151, os mais ativos e que tiveram seus mecanismos de indução de morte investigados. Estudos teóricos subsequentes realizados com os análogos de maior atividade (RPF-101 e RPF-151), revelaram que as modificações moleculares promovidas nas estruturas dos mesmos conferiram maior caráter hidrofílico e maior momento de dipolo, o que pode estar relacionado com o incremento na atividade biológica de ambos. A avaliação dos compostos ativos frente às propriedades constantes na Regra dos Cinco de Lipinski (RO5) revelou que estes respeitam todos os parâmetros da regra, enaltecendo assim o caráter druglikeness dos mesmos, em serem ativos via administração oral, visto que o RPF151 não apresentou ação pungente in vivo. A obtenção dos compostos RPF-101 e RPF-151 indicam o sucesso alcançado com a otimização estrutural promovida no arcabouço capsaicinóide, e enaltece o potencial destes análogos em inspirar o planejamento de novas estruturas, ainda mais otimizadas, que possuam maior potência e menor toxicidade associada.
Cancer is the second most lethal group of diseases all over the world, just behind cardiovascular diseases. This scenery is worrying in Brazil due the pronounced aging trend observed, that presents the higher incidence of cancer. In this context, the current anticancer therapy still have several biases regarding toxicity and selectivity. Many current medicines correlate to natural products, even in its early stages of development, which highlight the importance of natural sources in the design of new bioactive compounds. Capsaicin is the substance responsible for the pungency of Capsicum genus\' chili peppers. Capsaicin has been shown as an important natural agent because of its cytotoxic activity against several tumor cell lines. However, the pungency and poor stability presented by capsaicin restricts its therapeutic employments. Thus, the capsaicinoid scaffold has a great potential to inspire the design of new bioactive analog entities to be employed in anticancer therapy. This project aimed at designing and synthesizing sulfonamide and sulfonate analogues of capsaicin, performing molecular changes on capsaicinoid core. After a single step synthesis, the analogues were purified and characterized by melting point, 1H/13C NMR and elementary analysis. Subsequently, cytotoxicity assays were performed by MTT method on tumor cell lines MDA-MB-231 and MCF-7 (breast cancer), B16-F10 (murine melanoma) and on healthy fibroblast (3T3). Four compounds showed interesting biological activity at micromolar concentrations (µM) and their IC50 were lower than that presented by capsaicin. The most active compounds, RPF-101 and RPF-151, had their death induction mechanisms investigated. In silico subsequent studies with the most active compounds (RPF-101 and RPF-151) showed that molecular changes promoted on each one increased their hydrophilicity and raised their dipole moment, which may be related to the improvement on biological activity of both. The evaluation of active compounds for Lipinski´s Rule of Five (RO5) properties revealed that they respect all properties presenting its druglikeness for oral administration since RPF151 did not presented in vivo pungency. The RPF-101 and RPF-151 indicate the success obtained by the structural optimization promoted on capsaicinoid scaffold and emphasizes the potential of these analogues to inspire the designing of new future optimized structures, with greater potency and less associated toxicity.
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NASCIMENTO, Patrícia Lins Azevedo do. "Atividade antioxidante e antimicrobiana da pimenta malagueta (Capsicum frutescens)." Universidade Federal Rural de Pernambuco, 2013. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4651.

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Pimenta malagueta (Capsicum frutescens) as it is known in Brazil, is one of the pepper species most used in cooking and in Brazilian folk medicine. Antioxidant and antimicrobial activities, total phenolic compounds and capsaicin, dihydrocapsaicin and crisoeriol content were analyzed. The content of capsaicin, dihydrocapsaicin and crisoeriol found was 9.2, 4.0 and 2.1 mg/g extract, respectively. The minimal inhibitory concentration was determined against six bacteria strains and Candida albicans but for all of them were necessary concentrations higher than 1000 μg/ml. The total phenolic content was 9.1 mg GAE/g extract. The ethanolic extract of C. frutescens had an effective DPPH and ABTS + scavenging (CE50 of 302.3 and 82.6 g/ml respectively) and percentage of antioxidant activity by β-carotene/linoleic acid assay that ranged from 15 to 47%. The main groups of compounds extracted from plants with biological properties are essential oils, alkaloids, glycosides, phenolic compounds, terpenoids and flavonoids. Our results suggest that C. frutescens contains a potential antimicrobial and antioxidant that can be associated with its phenolic, capsaicinoids and flavonoid contents.
Pimenta malagueta (Capsicum frutescens), como é conhecida no Brasil, é uma das espécies de pimenta mais usadas na culinária e na medicina popular brasileira. Foram analisadas as atividades antioxidante e antimicrobiana, o teor de fenólicos totais, capsaicina, dihidrocapsaicina e crisoeriol. O teor de capsaicina, dihidrocapsaicina e crisoeriol encontrado foi de 9,2, 4,0 e 2,1 mg/g de extrato respectivamente. A concentração inibidora mínima foi determinada frente seis linhagens de bactérias e da levedura Candida albicans, mas para todos os micro-organismos testados foram necessárias concentrações superiores a 1000 μg/mL. O teor de fenólicos totais foi de 9,1 mg equivalentes de ácido gálico/g de extrato. O extrato etanólico de C. frutescens apresentou atividade eficiente frente aos radicais DPPH e ABTS + (CE50 de 302,3 e 82,6 μg/mL, respectivamente) e porcentagem de atividade antioxidante pelo ensaio β-caroteno/ácido linoleico que variou de 15 a 47%. Os principais grupos de compostos extraídos de plantas com propriedades biológicas são os óleos essenciais, alcaloides, glicosídeos, compostos fenólicos, terpenoides e flavonoides. Os nossos resultados sugerem que C. frutescens contém um potencial antimicrobiano e antioxidante que pode estar associado com o seu teor de fenólicos, capsaicinoides e flavonoides.
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Books on the topic "Capsaicin"

1

Abdel-Salam, Omar M. E., ed. Capsaicin as a Therapeutic Molecule. Basel: Springer Basel, 2014. http://dx.doi.org/10.1007/978-3-0348-0828-6.

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N, Wood John, ed. Capsaicin in the study of pain. London: Academic Press, 1993.

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Srivastava, Sanjay K., ed. Role of Capsaicin in Oxidative Stress and Cancer. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6317-3.

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T, Stock Melissa, and Hunter Kellye, eds. The healing powers of peppers: Chile pepper recipes and folk remedies for better health and living. New York: Three Rivers Press, 1998.

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Manteghian, M. Extraction of chemicals from plants: capsaicin ( chilli flavour ) from capsicum. Manchester: UMIST, 1985.

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Law, D. Studies related to the production of capsaicin by capsicum frutescens cells. Manchester: UMIST, 1993.

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Salazar, Mario Alfonso, and Jose Miguel Ortega. Peppers: Nutrition, consumption, and health. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Christensen, Richard G. Preliminary investigation of Oleoresin Capsicum. Washington, D.C: U.S. Dept. of Justice, Office of Justice Programs, National Institute of Justice, 1995.

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DeWitt, Dave. El poder curativo de los pimientos: Con recetas de chiles y remedios caseros para mejorar la vida y la salud. Nueva York: Random House Español, 2001.

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Kwan, Chun Leung. Neuroplasticity of rat trigeminal subnucleus oralis neurons after tooth pulp deafferentation and after depletion of somatosensory c-fiber affrents with neonatal capsaicin treatment. Ottawa: National Library of Canada, 1994.

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Book chapters on the topic "Capsaicin"

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Bährle-Rapp, Marina. "Capsaicin." In Springer Lexikon Kosmetik und Körperpflege, 89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_1645.

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Pradhan, Rohan, and Alaa Abd-Elsayed. "Capsaicin." In Pain, 339–41. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-99124-5_74.

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Smeets, Astrid J. P. G., and Margriet Westerterp-Plantenga. "Capsaicin." In Weight Control and Slimming Ingredients in Food Technology, 201–11. Oxford, UK: Wiley-Blackwell, 2009. http://dx.doi.org/10.1002/9780813819679.ch12.

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Resnick, Barbara. "Capsaicin." In Encyclopedia of Behavioral Medicine, 366–67. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_1570.

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Resnick, Barbara. "Capsaicin." In Encyclopedia of Behavioral Medicine, 326–27. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1570.

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Misery, Laurent. "Capsaicin." In Pruritus, 265–67. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-322-8_40.

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Misery, Laurent. "Capsaicin." In Pruritus, 351–54. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33142-3_45.

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Yang, Xiu-Ying, and Guan-Hua Du. "Capsaicin." In Natural Small Molecule Drugs from Plants, 397–402. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8022-7_66.

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Ferrer-Montiel, Antonio Vicente. "Capsaicin Receptor." In Encyclopedia of Pain, 460–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28753-4_555.

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Bevan, Stuart. "Capsaicin and pain mechanisms." In Pain and Neurogenic Inflammation, 61–80. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8753-3_4.

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Conference papers on the topic "Capsaicin"

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Tek, Erhan, and Nizami Duran. "Efficacy of Capsaicin on Cell Adhesion and Invasion of Oral Pathogens." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.iii.19.

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Streptococcus pyogenes, Streptococcus mutans, and Candida albicans are important human pathogens and their infections in the mouth, mouth, and throat are important. Prophylaxis against oral and respiratory tract infections is of great importance in terms of both reducing the use of antibiotics and lowering the infection frequency. This study investigated the antimicrobial activity of Capsaicin against S. mutans, C. albicans, and S. pyogenes. Non-cytotoxic concentration of Capsaicin was determined in the Vero cell line by the MTT method. Efficacy studies were performed within these determined non-cytotoxic concentrations. The efficacy of single and different combinations of these three biological components on cell adhesion and invasion. The non-toxic concentration of capsaicin on Vero cells was <1.35 µg/ml. Capsaicin exhibited significant antimicrobial activity against S. pyogenes, S. mutans, and C. albicans. Moreover, capsaicin was statistically significantly effective against host cell adhesion and invasion against S. mutans, S. pyogenes and C. albicans compared to the control group. The results showed that capsaicin is a highly potent antibacterial agent against S. pyogenes, and S. mutans, as well as an important prophylactic agent for fungal infections. As a result, we think that capsaicin is a useful molecule for the provision and maintenance of both respiratory diseases and oral health.
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Koç, Mehmet, Emine Varhan, Zehra Kasımoğlu, and Hilal Şahin Nadeem. "The effect of different wall materials on the production of suppressed-pungent capsaicin microparticles." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7721.

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The aim of this study was to investigate the effects of wall materials types on the production of double-layered and suppressed-pungent capsaicin microparticles via spray chilling method. For this purpose, palm oil and different proteins (gelatin, sodium caseinate and whey protein) were used as wall materials, while soy lecithin was selected as stabilizer. Sample encapsulated only with palm oil (single-layered) was used as control. Centrifuge stability and kinetic stability were analyzed on the prepared emulsions. Total and surface capsaicin, microencapsulation efficiency, melting point temperature and fusion enthalpy analysis were carried out on the capsaicin microparticles obtained by spray chilling.Keywords: Capsaicin; Spray chilling method; Pungency; Double-layered microparticles
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Costa, Raisa Ferreira, Emanuela Paz Rosas, Daniella Araújo de Oliveira, and Marcelo Moraes Valença. "Action of capsaicin in the degranulation of mast cells in dura mater of rats: literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.001.

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Introduction: Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells. Design: A survey was carried out in the literature, from 1980 to 2019, in different databases (SciELO, U.S. National Library of Medicine and the National Institutes Health (PubMed) and Web of Science) using the following terms: capsaicin, mast cell and dura mater. Methods: 36 articles were selected for this review. The inclusion criteria were experimental model studies in rats that described the mechanisms of action of chemical inducers, including capsaicin. Results: Studies indicate that the main mechanisms of action of capsaicin are chemical induction through the activation of TRPV1 channels, allowing calcium influx into neurons in the trigeminal ganglion of the dura mater, activating mast cell degranulation, releasing pro-inflammatory (e.g., histamine, oxide nitric) and vasoactive (e.g., CGRP and substance P) substances. Conclusion: Therefore, the use of capsaicin may be a tool to be used in na animal model to better understand the pathophysiology of migraine.
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Menezes, Andriele da Silva, Luiz Felipe Dias Carli, and Nathieli Bianchin Bottari. "OS EFEITOS DA CAPSAICINA E SEU USO COMO UM POTENCIAL AGENTE TERAPÊUTICO NO TRATAMENTO DO CÂNCER: UM REVISÃO SISTEMÁTICA DA LITERATURA." In I Congresso Brasileiro de Saúde Pública On-line: Uma abordagem Multiprofissional. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2837.

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Introdução: O câncer é o principal problema de saúde pública no mundo, por esse motivo é imprescindível uma busca por novos compostos que apresentem atividade antitumoral. Cerca de 50% dos medicamentos quimioterápicos disponíveis no mercado possuem princípio ativos de origem natural ou derivados semissintéticos. Atualmente, há uma grande procura pela capsaicina, um composto biologicamente ativo derivado da pimenta, devido suas propriedades anti-inflamatórias, antibacterianas e antioxidantes, além de ser um alvo para o tratamento de diversas doenças, como o câncer. Objetivo: o objetivo desta revisão foi sintetizar os efeitos anticancerígenos da capsaicina em seres humanos através de uma revisão sistemática da literatura. Material e métodos: Para isso foi realizada uma revisão bibliográfica utilizando os seguintes descritores: “Capsaicin” and “anticancer” nas plataformas PubMed, Science Direct e Scielo, buscando artigos publicados nos últimos dez anos. Resultados: Estudos in vivo e in vitro mostraram que este composto natural atua em uma variedade de vias de sinalização em diferentes tipos de câncer e produz efeitos anti-proliferação, anti-sobrevivência e anti-migração em uma variedade de linhagens de células cancerosas. Estudos recentes utilizando capsaicina de alta pureza e protocolos padronizados fornecem evidências de que o potencial genotóxico e carcinogênico da capsaicina é bastante baixo e que a pureza da capsaicina é importante. Em estudos in vitro utilizando células prostáticas cancerígenas, a capsaicina estimulou cerca de 80% das células a sofrer apoptose, uma hipótese é que a capsaicina atua inibindo as enzimas do citocromo P450. Conclusão: Assim, foi visto que a capsaicina pode ser capaz de modular múltiplos alvos moleculares que são responsáveis pelo processo tumoral. Embora as aplicações terapêuticas sejam limitadas a estudos in vitro e/ou in vivo, mais estudos envolvendo ensaios clínicos com seres humanos são necessários. De modo geral, os estudos apontam para um efeito anticarcinogênico da capsaina, especialmente quando utilizada em combinação com outros agentes quimioterápicos.
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Duran, Nizami. "New Formulation Effective against SARS CoV-2 and H1N1." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.iii.11.

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People apply a wide variety of over-the-counter treatments as food supplements against respiratory tract infections. In this study, we investigated the antiviral efficacy of piperine, capsaicin, and glycyrrhetinic acid (GA) against coronaviruses (SARS-CoV-2) and Influenza viruses (H1N1), which are associated with acute respiratory infections. TCID50 concentrations of SARS-CoV-2 and H1N1 isolates were determined. Then, the effectiveness of phytochemicals against these viral isolates at non-toxic concentrations was investigated. For this purpose, the MTT method and RT-PCR techniques were used. Non-toxic concentrations of Capsaicin, Piperine, and GA on Vero cells were determined as 0.625 µg/ml, and Ceramide at 1.25 µg/ml and lower concentrations. It was determined that Capsaicin and Piperine showed very significant antiviral activity against SARS CoV-2 when compared to standard drugs at concentrations of 0.312 µg/ml. The effectiveness of GA was determined to be lower (0.625 µg/ml) than these two phytochemicals. Capsaicin, piperine, and GA exhibited antiviral activity on SARS-CoV-2 and H1N1 viral replication, especially the activity of the combination of capsaicin plus piperine against SARS CoV-2 was stronger than the activity against N1N1 than against H1N1. In addition, it was determined that the triple combination of these components exhibited stronger antiviral activity than single and double combinations, resulting in a significant decrease in the number of viral copies. We think that this new formulation containing three different phytochemical compounds is effective against SARS-CoV-2 and influenza viruses, which are the most important causes of morbidity and mortality from respiratory tract viruses, and can be effective, especially for prophylactic purposes.
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Liu, Yi, Xiaoqi Shao, Jing Huang, and Hua Li. "Flame Sprayed Environmentally Friendly High Density Polyethylene (PE) and Capsaicin Composite Coatings for Marine Antifouling Applications." In ITSC2018, edited by F. Azarmi, K. Balani, H. Li, T. Eden, K. Shinoda, T. Hussain, F. L. Toma, Y. C. Lau, and J. Veilleux. ASM International, 2018. http://dx.doi.org/10.31399/asm.cp.itsc2018p0732.

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Abstract Marine biofouling has emerged as worldwide serious problems for artificial marine infrastructures. Among the measures taken so far to solve such problems, construction of an antifouling layer has been proven to be effective in offering long-term antifouling performances. Antifouling based on the use of biocides is the most important method in modern maritime industries. While tributyltin (TBT)-based self-polishing coatings are being replaced by other biocide-releasing coatings, the environmental toxicity of these compounds is also under scrutiny. Therefore, there is a significant interest in developing non-toxic technologies. Green biocides can also be extracted from many types of organisms including terrestrial plants, sea creatures and bacteria. In this study, flame sprayed polyethylene (PE)-capsaicin composite coatings were developed for marine antifouling applications. Capsaicin powder were fixed by polymer-based substrate and distributed evenly. Antifouling test indicated excellent antibacterial properties of PE-capsaicin composite coatings against adhesion of marine Bacillus sp. bacteria. Prohibited formation of biofilm on the surfaces of the thermal sprayed composite coatings gives clear insight into their potential applications as antifouling layers in the marine environment.
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Holt, Kimberley, Rachel Dockry, Joanne Mitchell, John Belcher, and Jaclyn Smith. "Novel capsaicin challenge methodology: a new diagnostic endpoint?" In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.4561.

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Faruqi, Shoaib, Jaymin Morjaria, Caroline Wright, Rachel Thompson, and Alyn H. Morice. "Dextromethorphan Attenuates Capsaicin Induced Cough In Healthy Volunteers." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3568.

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Uzunovic, A., S. Pilipovic, A. Sapcanin, and Z. Ademovic. "Evaluation of transdermal drug-delivery system of capsaicin." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608515.

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Stevens, Randall, Kimberly Guedes, Eddie Armas, Valerie Smith, and Andrew Volosov. "THU0455 PHARMACOKINETICS (PK) OF A SINGLE INTRA-ARTICULAR (IA) INJECTION OF CNTX-4975 (TRANS-CAPSAICIN) VS TOPICAL 8% CAPSAICIN PATCH." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.5941.

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Reports on the topic "Capsaicin"

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Halvic, Ian William. Improving Capsaicin Sweep Performance Using Memory Prefetching. Office of Scientific and Technical Information (OSTI), August 2018. http://dx.doi.org/10.2172/1467295.

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Buys, Michael J. Use of the TRPV1 Agonist Capsaicin to Provide Long-Term Analgesia in a Rat Limb Fracture/Open Repair, Internal Fixation Model. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada569521.

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Buys, Michael J. Use of the TRPV1 Agonist Capsaicin to Provide Long-Term Analgesia in a Rat Limb Fracture/Open Repair, Internal Fixation Model. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada569523.

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Sinoff, Stuart E., and Mary B. Hart. A Pilot Study: Evaluation of the Effects of Treatment with 0.75% Topical Capsaicin in Patients with Reflex Sympathetic Dystrophy Using Three Phase Bone Scintigraphy. Fort Belvoir, VA: Defense Technical Information Center, January 1991. http://dx.doi.org/10.21236/ada234902.

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