Academic literature on the topic 'Cancer – Thérapeutique – Chez l'enfant'
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Journal articles on the topic "Cancer – Thérapeutique – Chez l'enfant"
Lervat, C. "Douleur cancéreuse chez l'enfant: actualités thérapeutiques." Bulletin du Cancer 96, spec2 (September 2009): 5–14. http://dx.doi.org/10.1684/bdc.2009.0889.
Full textDefachelles, Anne-Sophie, Nathalie Rocourt, Sophie Branchereau, and Michel Peuchmaur. "Le pancréatoblastome chez l'enfant : du diagnostic à la prise en charge thérapeutique." Bulletin du Cancer 99, no. 7-8 (July 2012): 793–99. http://dx.doi.org/10.1684/bdc.2012.1600.
Full textCauseret, S., J. C. Lifante, F. Borson-Chazot, F. Varcus, N. Berger, and J. L. Peix. "Cancers différenciés de la thyroïde chez l'enfant et l'adolescent : stratégie thérapeutique adaptée à la présentation clinique." Annales de Chirurgie 129, no. 6-7 (July 2004): 359–64. http://dx.doi.org/10.1016/j.anchir.2004.04.013.
Full textCacaille, F. "Les acides biliaires et leur utilisation thérapeutique chez l'enfant." Archives de Pédiatrie 2, no. 12 (December 1995): 1200–1208. http://dx.doi.org/10.1016/0929-693x(96)89923-4.
Full textVidailhet, M. "Prise en charge thérapeutique des obésités chez l'enfant et l'adolescent." Journal de Pédiatrie et de Puériculture 11, no. 3 (May 1998): 180–83. http://dx.doi.org/10.1016/s0987-7983(98)80141-2.
Full textSadaoui, M., M. Djeled, I. Bakhtaoui, D. Batouche, and M. A. Boukli Hacene. "P-004 – Le phèochromocytome chez l'enfant: approche diagnostique et thérapeutique." Archives de Pédiatrie 22, no. 5 (May 2015): 234. http://dx.doi.org/10.1016/s0929-693x(15)30189-5.
Full textFerré, Guillaume. ""Oh toi avec ta Loi !" accompagnement d'une fratrie dans le cadre de violences intrafamiliales." Psy Cause N° 87, no. 4 (January 23, 2024): 30–39. http://dx.doi.org/10.3917/psca.087.0030.
Full textOsusky, Pauline. "Le cancer du sein chez l'enfant." Journal de Pédiatrie et de Puériculture 5, no. 2 (March 1992): 125. http://dx.doi.org/10.1016/s0987-7983(05)80265-8.
Full textBergès-Bounes, Marika, and Agnès Lauras-Petit. "De l'individu dans le groupe : la relaxation thérapeutique chez l'enfant et l'adolescent." Revue de psychothérapie psychanalytique de groupe 47, no. 2 (2006): 179. http://dx.doi.org/10.3917/rppg.047.0179.
Full textChraïbi, S. "Thérapeutique du syndrome de répétition chez l'enfant et l'adolescent victimes d'agressions sexuelles." Annales Médico-psychologiques, revue psychiatrique 164, no. 2 (March 2006): 134–40. http://dx.doi.org/10.1016/j.amp.2005.12.004.
Full textDissertations / Theses on the topic "Cancer – Thérapeutique – Chez l'enfant"
Pinchon, Catherine. "Papillomatose laryngée chez l'enfant : mise au point des modalités thérapeutiques : à propos de quatre observations." Caen, 1992. http://www.theses.fr/1992CAEN3041.
Full textLecompte, Hélène. "Une institution « totale » : enquête ethnographique d'un service d'oncopédiatrie." Nantes, 2013. http://www.theses.fr/2013NANT3034.
Full textFabry, Valérie. "Les deuxièmes tumeurs malignes de l'enfant : à propos de 14 observations." Bordeaux 2, 2001. http://www.theses.fr/2001BOR23008.
Full textIlharramounho, Patricia. "Les rhabdomyosarcomes de l'enfant : données cliniques, paracliniques, thérapeutiques et évolution : à propos de onze patients." Bordeaux 2, 1990. http://www.theses.fr/1990BOR25126.
Full textDif, Lydia. "Fascin-1 as a druggable target in Hepatoblastoma." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0104.
Full textHepatoblastoma (HB) is the most common liver tumor in children, the survival rate of patients has increased thanks to intensive chemotherapy. Unfortunately, this strategy creates lifelong side effects in survivors who become disabled, with one third ending up with hearing loss and subsequent disability.Another characteristic of this cancer is its low mutational burden, the main pathways that are dysregulated are the Wnt and Hippo pathways. β-catenin, the main effector of the Wnt pathway, harbors activating mutations in 80% of HB tumors. When β-catenin is exon 3 deleted, it removes its ability to be degraded by a destruction complex. β-catenin translocates into the nucleus where it acts as a co-transcription factor promoting the expression of pro-survival genes.Our work, on cell lines, patient samples and mouse models of HB, shows that an actin-binding protein called fascin-1 is an effector of β-catenin and exerts a pro-oncogenic effect. Fascin-1 is responsible for actin bundling that leads to the formation of cell structures such as filopodia and invadopodia, which facilitate cell migration and invasion. The role of fascin is particularly important during embryonic development, but fascin expression decreases in most adult epithelial tissues. Fascin is absent in hepatocytes but interestingly is re-expressed during tumorigenesis. We find it co-expressed with β-catenin in tumors and furthermore fascin is a marker of undifferentiated cells. Its knockdown with siRNA strategy leads to a decrease of cell growth in HepG2 cells.We sought to investigate the effect of fascin inhibition on various HB model cells and patient-derived xenograft cells. We target fascin actin bundling activity with a pharmacological inhibitor already in phase 2 clinical trials for solid tumors. Our study explores the effect on proliferation, cell death and senescence, invasion and migration, epithelial to mesenchymal transition and the underlying mechanism linking fascin to HB tumorigenesis, which could be the Hippo pathway.Our results show a clear effect of fascin inhibition on tumorigenesis with all the listed parameters and most interestingly we show a link between fascin inhibition and increased differentiation. This relationship has never been shown before. Furthermore, we show that Yap may be a potential downstream effector of fascin, closing the bridge between β-catenin and Yap in HB.Our results demonstrate that fascin inhibition in HB could be an interesting new application to explore for the ongoing clinical trial with NPG20444. We hope that positive results would lead to the inclusion of HB in this trial and ultimately that fascin inhibition would lead to the proposal of targeted therapeutic options for HB patients
Meyer, Swann. "Molecular characterization of aggressive cell states in pediatric gliomas and sarcomas." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10364.
Full textAlthough considered a rare disease, pediatric cancers are the 2nd leading cause of death in children under the age of 14 in Western countries. Considerable progress was made in the 1970s, with an overall survival of 70% achieved in around twenty years. Nevertheless, certain subgroups are still associated with a poor prognosis, and the matter of treatment-related sequelae remains. These challenges partly stem from the fact that the majority of treatments for pediatric cancers were initially developed for adult cancers, even though we now know that they have their own particularities, notably in terms of biology. It is therefore important to identify the specificities of pediatric cancers to better target their vulnerabilities. The work of this thesis focused on the bioinformatic characterization of the molecular components involved in tumor aggressiveness, in two types of pediatric tumors: diffuse midline gliomas (DMG) and rhabdomyosarcomas (RMS). In both cases, we identified oncogenic signals involved in the acquisition of an invasive phenotype, and highlighted a new individual factor likely to play a prognostic role in RMS. Lastly, these studies are concluded by epistemological reflections on the role of multi-omics technologies in oncology, which have been central throughout this work
Bittan, Carole. "Impact du G-CSF dans les neutropénies chimio-induite chez les enfants en rechute de leucémies aigue͏̈s lymphoblastiques." Paris 5, 1994. http://www.theses.fr/1994PA05P216.
Full textTourbez, Arthur. "Développement et caractérisation d'organoïdes de tumeurs cérébrales pédiatriques utilisés en recherche fondamentale et translationnelle." Electronic Thesis or Diss., Lyon 1, 2023. https://n2t.net/ark:/47881/m6416x50.
Full textPediatric high-grade gliomas (pHGG) and posterior fossa type A ependymomas (EPN-PFA) remain one of the biggest challenges in pediatric oncology. They exhibit vast inter- and intra-tumoral heterogeneity, complicating the development of effective therapeutic strategies. Then to improve their clinical outcome, we absolutely need pre-clinical models that recapitulate key features of their corresponding parental tumors. During my PhD, I developed an optimized protocol for the establishment and biobanking of pHGG organoids (pHGG_O) and EPN-PFA organoids (EPN-PFA_O). These models can be grown long-term and comprehensive histological and molecular analyses showed that they recapitulate inter- and intra-tumoral heterogeneity of their parental tumor even after several passages and cryopreservation as 3D cultures. I further showed that they can be employed to test responses to standard of care therapy as well as new therapeutic options, including drugs from clinical trials as they accurately capture the clinical phenotypes of their respective parental tumors. Moreover, these models led to the identification of the DRD2 inhibitor ONC201 as an unexpected potential therapeutic agent for H3K27M non-altered pediatric brain tumors and helped identify combination strategies to increase the therapeutic response to ONC201. Thus, those models are positioned to support powerful and innovative preclinical studies, particularly those related to personalized assessments of treatment response profiles and identification of novel efficient drug combinations
Herbinet, Aline. ""L'amour au coeur du mouvement" : la nécessité du transfert dans un dispositif inédit d'activités physiques adaptées proposé dans le service d'hémato-oncologie pédiatrique de Nancy." Nancy 1, 2002. http://docnum.univ-lorraine.fr/public/SCD_T_2002_0050_HERBINET.pdf.
Full textThis research stems from a ten-year experience of Adapted Physical Activities with children and teenagers who were hospitalised in an hemato-oncology ward. This research aims at describing and theorising the impact of ludic adapted physical activities on children, teenagers, the medical staff, and the members of the APA team. The unconscious aspects of the relationships between these intervenants have been studied, where individuals responded in their own way to the difficult time they had to go through. The research emphasises the importance, complexity and particularity of the pedagogical and human relationships - all the more because the APA are proposed to patients whose body also showed signs of suffering from a lethal disease. I attempted to define the nature of the necessary transference between the young patient and the person who engaged him in practising the APA. This was achieved in a constant to and fro between on-the-field practice and analysis of psychanalytical theory. The assumption was that it was necessary to analyse the APA sessions and their effects in light of the transference that had emerged between the patient and the APA teacher. The member of the APA team will then use his unconscious knowledge of this one to one relationship to adapt to the patient, and by this broaden and modify his/her theoretical approach to pedagogy and research
Fresneau, Brice. "Analyses pronostiques en oncologie pédiatrique : Identification de facteurs de susceptibilité tumorale ou individuelle à l’efficacité et/ou à la toxicité des traitements anticancéreux utilisés chez l’enfant Investigating the Heterogeneity of Alkylating Agents' Efficacy and Toxicity Between Sexes: A Systematic Review and Meta-Analysis of Randomized Trials Comparing Cyclophosphamide and Ifosfamide (MAIAGE Study) Is Alpha-Fetoprotein Decline a Prognostic Factor of Childhood Non-Seminomatous Germ Cell Tumours? Results of the French TGM95 Study New Insight into Severe Ototoxicity after Childhood Cancer. Is there an Impact of Melphalan and Busulfan? A French Childhood Cancer Survivor Study A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated with High-Dose Methotrexate: Data from the OS2006/Sarcoma-09 Trial." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS034.
Full textTherapeutic advances in pediatric oncology have improved survival rates reaching over 80%. In order to increase cure rates and decrease complications and treatment sequelae, international collaborative efforts led to the development of therapeutic trials stratified on major prognostic factors including biological factors. However, treatment adaptation to individual patient characteristics remains marginal.In this thesis, our objective was to better understand how somatic (tumor-related) and constitutional (patient-related) characteristics could modify efficacy and toxicity of anticancer therapies used in pediatric oncology. Several works were performed: 1- Prognostic analysis of tumor markers: assessment of the alpha-foetoprotéine (AFP) decline prognostic value in childhood malignant germ cell tumors; 2- Prognostic analysis of constitutional factors: (i) assessment of the interaction between gender and type of alkylating agents on efficacy and acute toxicity; (ii) assessment of the efficacy and toxicity impact of genetic polymorphisms in patients with osteosarcoma treated with high-dose methotrexate; 3- Risk factors analysis of long-term toxicities: analysis of severe ototoxicity in the French Childhood Cancer Survivors Study (FCCSS)
Books on the topic "Cancer – Thérapeutique – Chez l'enfant"
Oppenheim, Daniel. Grandir avec un cancer: L'expérience vécue par l'enfant et l'adolescent. Belgique: De boeck, 2003.
Find full textBélair, Jean-François, and Patricia Garel. Prescrire une médication chez l'enfant: Entre miracle et sacrilège. Montréal: Hôpital Sainte-Justine, 1998.
Find full textPostiaux, Guy. Kinésithérapie respiratoire de l'enfant: Les techniques de soins guidées par l'auscultation pulmonaire. 3rd ed. Bruxelles: De Boeck, 2003.
Find full textDelaigue-Cosset, Marie-France. Ces enfants qui vivent le cancer d'un parent. Paris: Espace éthique, 2005.
Find full textBaudet, Monique. Le Fil ténu de la vie: Les enfants atteints de cancer. Paris: Éditions Ouvrières, 1985.
Find full textJean-Albert, Gastaut, Costello Régis, and Poizot-Martin Isabelle, eds. VIH/SIDA et cancers: Les affections malignes au cours de l'infection par le VIH. Paris: Ellipses Marketing, 2001.
Find full textInternational Agency for Research on Cancer., ed. Epidemiology of childhood cancer. Lyon, France: International Agency for Research on Cancer, 1999.
Find full textZeltzer, Lonnie K. Comprendre et vaincre la douleur chronique de votre enfant. Paris: Retz, 2007.
Find full textSarfati, Sonia. Kamylle et Melanie: D'apres une histoire vecue. Montreal: Hurtubise HMH, 2004.
Find full textMonnier, Louis, and Carole Fumat. Diabétologie. Issy-les-Moulineaux: Elsevier Masson, 2010.
Find full textBook chapters on the topic "Cancer – Thérapeutique – Chez l'enfant"
Sculier, J. P., A. P. Meert, and T. Berghmans. "Urgences et complications iatrogènes chez le patient cancéreux." In Thérapeutique du cancer, 131–49. Paris: Springer Paris, 2011. http://dx.doi.org/10.1007/978-2-8178-0021-9_9.
Full textFreyer, G. "Cancer du sein métastatique chez la femme âgée : de l’évaluation gériatrique à la décision thérapeutique." In Cancer du sein en situation métastatique, 323–36. Paris: Springer Paris, 2010. http://dx.doi.org/10.1007/978-2-8178-0076-9_33.
Full textOger, A. S., M. Boukerrou, L. Campion, E. Rousseau, J. F. Le Brun, E. Bussières, and J. M. Classe. "Le cancer du sein chez l’homme Approche épidémiologique, diagnostique et thérapeutique : étude multicentrique rétrospective à propos de 95 cas." In Acquis et limites en sénologie / Assets and limits in breast diseases, 363–67. Paris: Springer Paris, 2013. http://dx.doi.org/10.1007/978-2-8178-0396-8_62.
Full textVera, Louis. "Chapitre 7. Synthèse et décision thérapeutique." In TDA/H chez l'enfant et l'adolescent, 204–37. Dunod, 2015. http://dx.doi.org/10.3917/dunod.vera.2015.01.0204.
Full textTyszler, Jean-Jacques. "L’observation et la thérapeutique dans la psychose de l’enfant." In Les psychoses chez l'enfant et l'adolescent, 289. ERES, 2016. http://dx.doi.org/10.3917/eres.berge.2016.02.0289.
Full textGandelet, J. P. "Du jeu traumatique au jeu thérapeutique chez l'enfant traumatisé." In Traumatismes psychiques, 181–91. Elsevier, 2007. http://dx.doi.org/10.1016/b978-2-294-07144-7.50018-x.
Full textVander Haegen, Marie, Céline Stassart, Caroline Tilkin, Charlotte Grégoire, and Cécile Flahault. "Ajustement psychoclinique de l’adulte et de l’enfant dans le champ de l’oncologie." In Pratiques et interventions en psychologie de la santé, 153–64. Editions des archives contemporaines, 2020. http://dx.doi.org/10.17184/eac.3193.
Full textConference papers on the topic "Cancer – Thérapeutique – Chez l'enfant"
Akerzoul, N., and S. Chbicheb. "Cartographie des cancers de la cavité orale chez l’enfant." In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206603005.
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