Relevant bibliographies by topics / Cancer – Microbiology

Academic literature on the topic 'Cancer – Microbiology'

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Published: 4 June 2021
Last updated: 19 February 2022

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Journal articles on the topic "Cancer – Microbiology"

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Seppa, Nathan. "Microbiology: Receptor may be cancer accomplice." Science News 173, no. 5 (September 30, 2009): 77–78. http://dx.doi.org/10.1002/scin.2008.5591730515.

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Sobti, A., R. Hamaudi, and C. Hopper. "Spectra of oral cancer microbiology: a review." International Journal of Oral and Maxillofacial Surgery 44 (October 2015): e146. http://dx.doi.org/10.1016/j.ijom.2015.08.812.

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Gonzalez, Carmen E., Tami N. Johnson, Lisa M. Kidin, Scott Evans, Yvette DeJesus, Kenneth V. I. Rolston, and Ronald Stewart Walters. "Compliance with established pneumonia core measures at MD Anderson Cancer Center in the emergency center." Journal of Clinical Oncology 30, no. 34_suppl (December 1, 2012): 189. http://dx.doi.org/10.1200/jco.2012.30.34_suppl.189.

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189 Background: Pneumonia is the major cause of death due to infectious diseases in the United States. In the cancer patient, pneumonia is the overall leading infectious cause of death. Pneumonia Core Measures (PCM) and Clinical Pathways are frequently used by healthcare organizations to ensure the delivery of high-quality care and pathogen-directed therapy. A multidisciplinary team was organized at the University of Texas MD Anderson Cancer Center (MDACC) Emergency Center (EC) into a Pneumonia Team to optimize care and to enhance compliance with current PCM. Methods: A retrospective review of EC patients during pneumonia season was completed. Results: Three areas for improvement in the EC were identified. The areas include lack of EC staff’s knowledge on PCM, lack of standardized order-sets for pathogen-directed treatment, and cancer patients presenting with pneumonia syndromes that fall outside established Community-Acquired Pneumonia (CAP) guidelines. The identified problems were addressed through three strategies: Intense EC staff education initially and yearly prior to pneumonia season (September-March). Microbiologic analysis of the pathogens responsible for the pneumonias in our unique cancer population at MDACC. Development and implementation of an institutional pneumonia algorithm and an order-set. The Pneumonia Team also identified a gap between our patient population and the current PCM. Pneumonia patients at MDACC EC are divided into two distinct groups, solid tumor and hematologic cancers. The microbiology analyzed in both groups is consistent with Healthcare-Associated Pneumonia (HCAP) and not CAP. Microbiology analysis identified gram positive, gram negative, fungal, viral and multi-drug resistant organisms. The initial analysis demonstrated that 87% of our patients met criteria for HCAP and only 12% met CAP. Based on this percentage, antibiotic selection for our CAP patients comprises a small portion of our total population. Conclusions: Our current algorithm and order-set optimize care and minimize variation to match our patient population. These findings provide important considerations for policy makers in regard to pneumonia measurements in a cancer setting.
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G. Robayo, D. Adriana, Raquel F. Hernandez, Alveiro T. Erira, Ljubov Kandaurova, Celia L. Juarez, Victoria Juarez, and Angel Cid-Arregui. "Oral Microbiota Associated with Oral and Gastroenteric Cancer." Open Microbiology Journal 14, no. 1 (February 10, 2020): 1–17. http://dx.doi.org/10.2174/1874285802014010001.

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When the normal microbiota-host interactions are altered, the commensal microbial community evolves to a dysbiotic status resulting in some species becoming pathogenic and acting synergistically in the development of local and systemic diseases, including cancer. Advances in genetics, immunology and microbiology during the last years have made it possible to gather information on the oral and gastrointestinal microbiome and its interaction with the host, which has led to a better understanding of the interrelationship between microbiota and cancer. There is growing evidence in support for the role of some species in the development, progression and responses to treatment of various types of cancer. Accordingly, the number of studies investigating the association between oral microbiota and oral and gastrointestinal cancers has increased significantly during the last years. Here, we review the literature documenting associations of oral microbiota with oral and gastroenteric cancers.
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Belusic-Gobic, Margita, Arijan Zubovic, Anamarija Predrijevac, David Harmicar, Robert Cerovic, Silvana Udovic Gobic, and Lorena Zubovic. "Microbiology of wound infection after oral cancer surgery." Journal of Cranio-Maxillofacial Surgery 48, no. 7 (July 2020): 700–705. http://dx.doi.org/10.1016/j.jcms.2020.05.011.

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S. Abbas, Oday, Dalia A. Abdul-Shaheed, and Rand M. Anwer. "Induce Cancer by Ochratoxin A." Journal of Pure and Applied Microbiology 12, no. 4 (December 30, 2018): 1825–28. http://dx.doi.org/10.22207/jpam.12.4.16.

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Hsu-Kim, Cynthia, Jeffrey B. Hoag, Guang-Shin Cheng, and Mark E. Lund. "The Microbiology of Postobstructive Pneumonia in Lung Cancer Patients." Journal of Bronchology & Interventional Pulmonology 20, no. 3 (July 2013): 266–70. http://dx.doi.org/10.1097/lbr.0b013e31829ddf01.

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Peterson, D. E., G. E. Minah, C. D. Overholser, J. B. Suzuki, L. G. DePaola, D. M. Stansbury, L. T. Williams, and S. C. Schimpff. "Microbiology of acute periodontal infection in myelosuppressed cancer patients." Journal of Clinical Oncology 5, no. 9 (September 1987): 1461–68. http://dx.doi.org/10.1200/jco.1987.5.9.1461.

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This study characterized the subgingival microbial flora associated with 27 acute exacerbations of preexistent periodontal disease in 24 patients with chemotherapy-induced myelosuppression. All but two acute periodontal infections developed at low granulocyte levels (less than 1,000/microL). Suspected pathogens were detected in high concentrations in subgingival plaque specimens in 17 episodes of acute periodontal infection; a single pathogen was recovered in ten acute infections, and more than one pathogen was recovered in seven acute infections. Staphylococcus epidermidis, Candida albicans, S aureus, and Pseudomonas aeruginosa predominated, with combinations of these detected in some patients. Concomitant bacteremias developed in two of these patients. The subgingival microflora associated with ten acute periodontal infections was characterized by predominantly indigenous microorganisms, which in nine episodes were in abnormal proportions compared with microbial profiles in noncancer patients with similar degrees of periodontal disease. These data demonstrate that pathogens normally associated with infections in myelosuppressed cancer patients, as well as indigenous oral flora, are associated with acute periodontal infections during granulocytopenia. This finding is important, since this body site has not commonly been recognized as a source for acute infection in these patients.
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Farrell, Paul. "Viruses and cancer society for general microbiology, symposium 37." FEBS Letters 194, no. 1 (January 1, 1986): 192. http://dx.doi.org/10.1016/0014-5793(86)80078-3.

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10

Brook, Itzhak, and Ronald Hirokawa. "Microbiology of Wound Infection after Head and Neck Cancer Surgery." Annals of Otology, Rhinology & Laryngology 98, no. 5 (May 1989): 323–25. http://dx.doi.org/10.1177/000348948909800501.

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Specimens of pus were obtained from 24 patients who developed postoperative wound infection after head and neck cancer surgery. Aerobic bacteria only were isolated in two instances (8%), anaerobic bacteria only in one (4%), and mixed aerobic and anaerobic bacteria in 21 (88%). A total of 146 isolates were recovered (66 aerobic and 80 anaerobic), an average of six isolates per specimen (2.7 aerobic and 3.3 anaerobic). The most frequently recovered isolates were Peptostreptococcus sp, Staphylococcus aureus, Bacteroides sp, Fusobacterium, and enteric gram-negative rods. Twenty-two isolates recovered from 17 wounds (71%) produced β-lactamase. These included all five isolates of S aureus and nine of 17 (53%) of the Bacteroides melaninogenicus group. The polymicrobial aerobic/anaerobic nature of postoperative wound infections after head and neck cancer surgery and the presence of β-lactamase-producing bacteria may have important implications for the management of these infections.
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Dissertations / Theses on the topic "Cancer – Microbiology"

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Arat, Seda. "A Systems Biology Approach to Microbiology and Cancer." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/75149.

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Systems biology is an interdisciplinary field that focuses on elucidating complex biological processes (systems) by investigating the interactions among its components through an iterative cycle composed of data generation, data analysis and mathematical modeling. Our contributions to systems biology revolve around the following two axes: - Data analysis: Two data analysis projects, which were initiated when I was a co-op at GlaxoSmithKline, are discussed in this thesis. First, next generation sequencing data generated for a phase I clinical trial is analyzed to determine the altered microbial community in human gut before and after antibiotic usage (Chapter 2). To our knowledge, there have not been similar comparative studies in humans on the impacts on the gut microbiome of an antibiotic when administered by different modes. Second, publicly available gene expression data is analyzed to investigate human immune response to tuberculosis (TB) infection (Chapter 3). The novel feature of this study is systematic drug repositioning for the prevention, control and treatment of TB using the Connectivity map. - Mathematical modeling: Polynomial dynamical systems, a state- and time- discrete logical modeling framework, is used to model two biological processes. First, a denitrification pathway in Pseudomonas aeruginosa is modeled to shed light on the reason of greenhouse gas nitrous oxide accumulation (Chapter 4). It is the first mathematical model of denitrification that can predict the effect of phosphate on the denitrification performance of this bacterium. Second, an iron homeostasis pathway linked to iron utilization, oxidative stress response and oncogenic pathways is constructed to investigate how normal breast cells become cancerous (Chapter 5). To date, our intracellular model is the only expanded core iron model that can capture a breast cancer phenotype by overexpression and knockout simulations.
Ph. D.
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Al, Kamal Nasrah Ali. "Immunotherapy for human breast cancer." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1452814566.

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Ciesielski, Francisco Isaak Nícolas [UNESP]. "Microrganismos oportunistas e exógenos na microbiota bucal de pacientes oncológicos submetidos à radioterapia de cabeça e pescoço." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/91426.

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Made available in DSpace on 2014-06-11T19:25:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-08Bitstream added on 2014-06-13T18:53:14Z : No. of bitstreams: 1 ciesielski_fin_me_araca.pdf: 340364 bytes, checksum: 27a652e37436beb5112aa9fdd7fb42ce (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O objetivo deste estudo foi avaliar a ocorrência de microrganismos exógenos e oportunistas (bactérias entéricas, pseudomonados, leveduras e Helicobacter pylori) na cavidade bucal de pacientes submetidos à radioterapia para tratamento de câncer de cabeça e pescoço. Cincoenta pacientes que iria receber radioterapia foram examinados antes, durante e 30 dias após radioterapia. Amostras de saliva, mucosa e biofilme foram coletadas e os microrganismos foram detectados por cultura e Reação em Cadeia da Polimerase (PCR). Candida albicans, C. tropicalis, C. krusei, C. glabrata e C. parapsilosis foram as leveduras mais prevalentes nos pacientes submetidos a radioterapia. Gêneros Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, e Pseudomonas forma as bactérias mais frequentemente cultivadas. As bactérias alvo foram cultivadas de 77.8% dos pacientes edêntulos e 46.9% dos pacientes dentados 30 dias após a radioterapia. Por PCR, estes microrganismos foram detectados em todos os pacientes edêntulos e 78.1% dos pacientes dentados. Bactérias não orais e espécies de Cândida foram mais prevalentes nestes pacientes. Modificações no meio ambiente oral devido a radioterapia parecem facilitar a colonização por estes microrganismos.
The aim of this study was to evaluate the occurrence of opportunistic and exogenous microrganisms (enteric bacteria, pseudomonads, yeasts and Helicobacter pylori) in the oral cavity of patients undergoing radiotherapy (RT) for treatment of head and neck cancer. Fifty patients receiving RT were examined before, during and 30 days after RT. Saliva, mucosa, and biofilm samples were collected and microorganisms were detected by culture and Polymerase Chain Reaction (PCR). Candida albicans, C. tropicalis, C. krusei, C. glabrata and C. parapsilosis were the most prevalent yeasts in patients submitted to RT. Genera Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, and Pseudomonas were the most frequently cultivated bacteria. Targeted bacteria were cultivated from 77.8% edentulous and 46.9% dentate patients 30 days after RT. By PCR, these microorganisms were detected from all edentulous patients and from 78.1% of dentate patients. Non-oral bacteria and Candida species were prevalent in these patients. Modifications of the oral environment due to RT seem to facilitate the colonization of these microorganisms.
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Mas, de Xaxars Rivero Teresa. "Descripció i quantificació de la microbiota intestinal associada al càncer colorectal." Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/94513.

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Colorectal Cancer is the main type of cancer in Spain. Up to 90% of the cases are sporadic in nature and its aetiology is still unclear. It is supposed to be a multi-factorial disease, where factors play an important role in the tumor onset and development, like microbiota. The main goal of this study was to describe and quantify the bacterial community of the intestinal mucosa associated to colorectal cancer patients. This work has revealed the existence of a bacterial dysbiosis in colorectal cancer patients, which is in agreement with previous research. Specific phylotypes previously descrived using stool samples and also new phylotypes were associated with this disease.Furthermore, streptococcal populations have been studied and also a case report from a patient who present an infection caused by E. faecalis at the same time of CRC diagnosed. Future research should focus on specific aspects of intestinal microbiota such as its interaction with the host, together with the mechanisms by which bacteria can affect on the onset of tumor in the colon.
El càncer colorectal és el tipus de càncer més abundant a Espanya. Fins el 90% dels casos són d'origen espontani i la seva etiologia és desconeguda malgrat existeixen diversos factors que poden afectar en el desenvolupament tumoral, com la microbiota. L'objectiu d'aquesta tesi ha estat analitzar la composició de la comunitat microbiana en mostres de mucosa intestinal quantitativa i qualitativament. Els resultats mostren una disbiosi en els malalts de càncer colorectal i una associació amb l'augment o disminució d'espècies bacterianes, així com l'augment de determinats filotips/gèneres. També s'ha analitzat les poblacions d'estreptococs i l'exposició d'un cas clínic d'un pacient amb càncer colorectal amb una infecció causada per E. faecalis. Estudis focalitzats en aspectes més específics de la relació hoste-microbiota, així com explorar nous mecanismes induïts per bacteris són necessaris per comprendre alguns aspectes de la carcinogènesis colorectal.
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Ciesielski, Francisco Isaak Nícolas. "Microrganismos oportunistas e exógenos na microbiota bucal de pacientes oncológicos submetidos à radioterapia de cabeça e pescoço /." Araçatuba : [s.n.], 2010. http://hdl.handle.net/11449/91426.

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Orientador: Elerson Gaetti Jardim Júnior
Banca: Alvimar Lima de Castro
Banca: Luis Fernando Landucci
Resumo: O objetivo deste estudo foi avaliar a ocorrência de microrganismos exógenos e oportunistas (bactérias entéricas, pseudomonados, leveduras e Helicobacter pylori) na cavidade bucal de pacientes submetidos à radioterapia para tratamento de câncer de cabeça e pescoço. Cincoenta pacientes que iria receber radioterapia foram examinados antes, durante e 30 dias após radioterapia. Amostras de saliva, mucosa e biofilme foram coletadas e os microrganismos foram detectados por cultura e Reação em Cadeia da Polimerase (PCR). Candida albicans, C. tropicalis, C. krusei, C. glabrata e C. parapsilosis foram as leveduras mais prevalentes nos pacientes submetidos a radioterapia. Gêneros Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, e Pseudomonas forma as bactérias mais frequentemente cultivadas. As bactérias alvo foram cultivadas de 77.8% dos pacientes edêntulos e 46.9% dos pacientes dentados 30 dias após a radioterapia. Por PCR, estes microrganismos foram detectados em todos os pacientes edêntulos e 78.1% dos pacientes dentados. Bactérias não orais e espécies de Cândida foram mais prevalentes nestes pacientes. Modificações no meio ambiente oral devido a radioterapia parecem facilitar a colonização por estes microrganismos.
Abstract: The aim of this study was to evaluate the occurrence of opportunistic and exogenous microrganisms (enteric bacteria, pseudomonads, yeasts and Helicobacter pylori) in the oral cavity of patients undergoing radiotherapy (RT) for treatment of head and neck cancer. Fifty patients receiving RT were examined before, during and 30 days after RT. Saliva, mucosa, and biofilm samples were collected and microorganisms were detected by culture and Polymerase Chain Reaction (PCR). Candida albicans, C. tropicalis, C. krusei, C. glabrata and C. parapsilosis were the most prevalent yeasts in patients submitted to RT. Genera Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, and Pseudomonas were the most frequently cultivated bacteria. Targeted bacteria were cultivated from 77.8% edentulous and 46.9% dentate patients 30 days after RT. By PCR, these microorganisms were detected from all edentulous patients and from 78.1% of dentate patients. Non-oral bacteria and Candida species were prevalent in these patients. Modifications of the oral environment due to RT seem to facilitate the colonization of these microorganisms.
Mestre
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6

Leveille, Simon. "Combination strategies in the development of oncolytic cancer therapy." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106483.

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The ability of certain viruses to exploit cancer cell abnormalities for their own replication represents a remarkable opportunity in the development of cancer therapy. Although oncolytic viruses such as Vesicular Stomatitis virus (VSV) possess a variety of intrinsic properties that can be exploited to this end, important aspects of their nature are not optimized for this purpose and may benefit from refinement. Therefore, strategies to enhance VSV's direct or immune-mediated tumor cell killing have been designed and tested in the course of the studies presented in this thesis. First, VSV was engineered to express the CD::UPRT suicide enzyme that allowed the conversion of a non-toxic, systemically delivered drug into a cytotoxic chemotherapeutic compound only at the tumor site. This strategy demonstrated a synergistic enhancement of tumor cell killing, with lysis of non-infected cancer cells contributing to increased efficacy in tumor cells partially resistant to VSV. In addition, combination treatment was optimized in vivo by taking into consideration the kinetics of virus replication at the tumor and the bioavailability of the non-toxic pro-drug. Results not only demonstrated enhanced therapeutic effects on tumor-bearing mice but also highlighted important characteristics of in vivo VSV replication kinetics. A second strategy combined VSV with an immunomodulatory approach in an attempt to boost VSV-induced anti-tumor adaptive immune response. Using Flt3L growth factor to promote dendritic cell population augmentation, antigen presentation capacity was highly enhanced concomitantly with VSV oncolysis. Although improving therapeutic outcome, the strategy did not improve anti-tumor adaptive immune response. The approach uncovered an unexpected aspect of the immune response: VSV treatment was found to profoundly affect the viability of immune cells and dendritic cells at the tumor and to block their migration to the draining lymphoid organs. Consequently, tumor antigen presentation was abolished. The absence of tumor antigen presentation following VSV treatment is a mechanistic explanation for the limited ability of VSV to induce a tumor-specific adaptive immune response. Altogether, the strategies developed in the course of this work enhanced VSV's oncolytic properties and greatly advanced our general understanding of VSV anticancer therapy.
Certains virus possèdent la capacité d'exploiter les défauts métaboliques des cellules cancéreuses pour leur propre réplication. Ces virus, nommés virus oncolytiques, représentent une remarquable opportunité pour le développement de thérapies contre le cancer. Malgré cette prédisposition, certaines caractéristiques des virus oncolytiques ne sont pas optimales pour cette fonction et pourraient être améliorées. Dans cette optique, des stratégies visant à augmenter l'oncolyse induite par le virus Vesicular Stomatitis (VSV) ont été développées et testées chez la souris au cours de ce doctorat. Dans un premier temps, VSV a été modifié génétiquement afin qu'il exprime l'enzyme suicide CD ::UPRT lui permettant de réaliser la conversion d'un composé non-toxique administré de façon systémique en composé cytotoxique uniquement au site de la tumeur. La stratégie a permis de démontrer une augmentation synergique de la lyse des cellules cancéreuses ainsi que l'induction de la mort de cellules cancéreuses non infectées et partiellement résistantes au VSV. De plus, la combinaison in vivo a été optimisée afin de tenir compte de la cinétique de réplication du virus à la tumeur ainsi que de la biodisponibilité de la drogue. Les résultats ont permis non seulement d'obtenir une amélioration de l'effet thérapeutique mais également de souligner d'importantes caractéristiques de la réplication virale in vivo. Dans une seconde stratégie, VSV a été combiné avec une approche d'immunomodulation ayant pour but d'engendrer une réponse immunitaire acquise spécifique à la tumeur. En employant le facteur de croissance Flt3L qui favorise la prolifération et la différentiation des cellules dendritiques, la capacité de présentation d'antigènes a été grandement renforcée simultanément à l'oncolyse induite par VSV. En dépit du fait que la combinaison n'a que partiellement amélioré l'effet thérapeutique, elle a révélé un aspect inattendu de la réponse immunitaire engendrée par VSV. Les résultats ont démontré que VSV affecte grandement la viabilité des cellules immunitaires et des cellules dendritiques à la tumeur, qu'il bloque leur migration aux organes lymphatiques et que, par conséquent, la présentation d'antigènes tumoraux est abolie. La démonstration de l'absence de présentation d'antigènes tumoraux suivant le traitement oncolytique de VSV représente un important concept expliquant la piètre capacité de VSV en ce qui a trait à l'induction d'une réponse immunitaire aquise spécifique à la tumeur. En conclusion, les stratégies développées aux cours de ces travaux ont permis d'améliorer les propriétés oncolytiques de VSV ainsi que de grandement contribuer à la compréhension de la thérapie anti-cancer de VSV.
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Lampraki, Eirini-Maria. "Role of the histone demethylase KDM6A in pancreatic cancer." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/38933/.

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Plummer, Kathleen Hope. "Cancer and Infection." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5293.

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E. coli is the most frequently isolated Gram negative pathogen from bacteremia in cancer patients and is repeatedly recovered from many other extraintestinal illnesses. These infections are commonly endogenous in nature and interfere with the treatment of cancer resulting in increased healthcare costs, morbidity, and mortality rates. Cancer and the treatments related to cancer cause alterations in the microbiome of the gut and other organs. Despite this point, there is a serious lack of knowledge about the genetic types of E. coli infecting cancer patients. This gap results in vague prevention strategies and limited treatment options for cancer patients. Multi Locus Sequence Typing (MLST) was used to successfully genotype 105 sequentially collected E. coli isolates from patients admitted to H. Lee Moffitt Cancer Center (HLMCC, Tampa, FL) with confirmed extraintestinal infections between 2010 and 2012. In total, 24 distinct genotypes (STs) have been identified in this dataset using EcMLST (STEC Reference Center). Of these, ST34 constituted 39% of the isolates and may represent a disseminating clone at HLMCC. Furthermore, 17 isolates not found in the EcMLST database have been identified. Importantly, phylogenetic analysis of DNA sequence data for MLMCC E. coli revealed only 22% of HLMCC E. coli clustered with ECOR reference strains commonly attributed to the B2 phylogroup of extraintestinal pathogenic E. coli (ExPEC). Four HLMCC E. coli belonging to ST171 and attributed to life-threatening blood infections clustered with Shiga toxin (Stx) producing E. coli (STEC) strain TW06296. HLMCC E. coli belonging to ST34 clustered with enteroaggregative E. coli (EAEC) strain TW10263. Importantly, these non-B2 phylogroup strains demonstrated more pathogenic potential than HLMCC E. coli clustered with B2 ExPEC,which included a higher incidence of bacteremia and sepsis, as well as resistance to first-line antibiotics. Upon further investigation, ST34 may equate to ST131 by another MLST database. These findings suggest that isolates previously characterized as commensal and intestinal pathogenic E. coli have an increased ability to cause infection outside of the gastrointestinal tract in cancer patients and that selective pressures are contributing to increased antibiotic resistance. These findings may change the approach to clinical management of E. coli infections at cancer centers.
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Hand, Nicholas. "Development of a Recombinant Attenuated Salmonella Cancer Vaccine." Thesis, The George Washington University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10635177.

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New treatments for neuroblastoma are desperately needed; high-risk neuroblastoma patients have a less than 50% five-year survival rate despite intensive treatment. The greatest impact on improving survival rates for cancer patients in recent years is the result of a number of immunotherapeutic approaches. A proportion of high-risk neuroblastoma patients undergo spontaneous regression, possibly mediated by the immune system, indicating the potential of immunotherapies targeting neuroblastoma-associated antigens. Recombinant attenuated Salmonella vaccines (RASV) are cost-effective and have shown efficacy against a number of pathogen-associated antigens and are easily adapted for use as cancer immunotherapies. Here we cloned survivin, a neuroblastoma tumor-associated antigen into RASV expression plasmids to develop 24 RASV candidate vaccines with an array of select phenotypes. While conventional recombinant attenuated Salmonella vaccines are permanently attenuated, the RASV used here are engineered with inducible in vivo attenuation and other delayed phenotypes shown to improve immune responses. Survivin expression did not impact the growth or stability of any of the RASV constructs. Six of the constructs were tested in vivo, the RASV survived in the gut lumen, and all RASV-immunized mice produced anti-Salmonella responses. Protein/adjuvant immunized mice produced humoral and cellular survivin specific immune responses; however two independent in vivo experiments showed that no survivin specific immune responses were induced in survivin-expressing RASV immunized mice. Based on the results, a number of improvements to the future development of the vaccine are suggested.

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Riggio, Alessandra I. "The role of Runx1 in genetic models of breast cancer." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/9103/.

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Given the recent discovery of RUNX1 somatic mutations in biopsies of breast cancer patients, the overall purpose of the present thesis consists of using different in vivo and ex vivo experimental systems in the attempt to answer two main questions: firstly, if the Runx1 gene plays any causative role in the context of breast cancer; and secondly, if its putative function is symptomatic of a tumour suppressor gene and/or of a pro-oncogene. By characterizing the effects of Runx1 deletion in two different breast cancer mouse models (i.e. the MMTV-PyMT and the Wnt/β-catenin-driven models of mammary tumourigenesis), this thesis provides the first in vivo evidence of a dualistic role played by the gene in the context of breast cancer. Runx1 would in fact appear to act as a tumour suppressor at early stages of the disease, whilst as a pro-oncogene at later stages of mammary tumourigenesis. To fully comprehend the significance of these major findings, the introduction will first provide a brief description on the RUNX family of genes, as well as on the state-of-the-art knowledge of RUNX1’s role in both mammary gland and breast cancer biology. As such, particular attention will then be given not only to the ontogeny, endocrine regulation and composition of the murine mammary gland, yet also to the high degree of heterogeneity, the putative “cell-of-origin(s)” and the different experimental models commonly used to study breast cancer. Through the aforementioned rationale, it is hoped that the introduction will serve as a platform which may hold the key for unveiling the controversial role played by RUNX1 in the context of breast cancer.
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Books on the topic "Cancer – Microbiology"

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Khan, Abdul Arif. Bacteria and Cancer. Dordrecht: Springer Netherlands, 2012.

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The cancer microbe. Los Angeles: Aries Rising Press, 1990.

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Rubin, Eric. Modulation of Protein Stability in Cancer Therapy. New York, NY: Springer-Verlag New York, 2009.

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Molecular biology of cancer. Oxford, UK: Bios Scientific Publishers, 1997.

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Macdonald, F. Molecular biology of cancer. 2nd ed. London: Taylor & Francis, 2004.

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Principles and practice of cancer infectious diseases. New York: Humana Pres/Springer, 2011.

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International, Duran-Reynals Symposium Viruses Oncogenes and Cancer (3rd 1984 Barcelona). Viruses, oncogenes and cancer: Third International Duran-Reynals Symposium , Viruses, Oncogenes and Cancer, Barcelona, Spain, May 14-17, 1984. Basel: Karger, 1985.

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Houghton, Peter J., and Robert Arceci. Molecularly targeted therapy for childhood cancer. New York: Springer, 2010.

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Lidbeck, Ann. Studies on the impact of Lactobacillus acidophilus on human microflora and some cancer-related intestinal ecological variables. [S.l: s.n.], 1991.

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Studies on the impact of lactobacillus acidophilus on human microflora and some cancer-related intestinal ecological variables. Stockholm: Kong. Carolinska Medico Chirurgiska Institutet, 1991.

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Book chapters on the topic "Cancer – Microbiology"

1

Arman, E., N. Katzir, G. Rechavi, and D. Givol. "Transposable Elements and Cancer." In Current Topics in Microbiology and Immunology, 90–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71562-4_12.

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Leoh, Lai Sum, Tracy R. Daniels-Wells, and Manuel L. Penichet. "IgE Immunotherapy Against Cancer." In Current Topics in Microbiology and Immunology, 109–49. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13725-4_6.

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Goldberg, Monica V., and Charles G. Drake. "LAG-3 in Cancer Immunotherapy." In Current Topics in Microbiology and Immunology, 269–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/82_2010_114.

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Dobbelstein, M. "Replicating Adenoviruses in Cancer Therapy." In Current Topics in Microbiology and Immunology, 291–334. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-05599-1_9.

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Piazuelo, M. Blanca, Rachel P. Riechelmann, Keith T. Wilson, and Holly M. Scott Algood. "Resolution of Gastric Cancer-Promoting Inflammation: A Novel Strategy for Anti-cancer Therapy." In Current Topics in Microbiology and Immunology, 319–59. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-15138-6_13.

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Irish, Jonathan M., and Deon B. Doxie. "High-Dimensional Single-Cell Cancer Biology." In Current Topics in Microbiology and Immunology, 1–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/82_2014_367.

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Lawrence, Toby. "Macrophages and NF-κB in Cancer." In Current Topics in Microbiology and Immunology, 171–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/82_2010_100.

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Ali, Omar A., and David J. Mooney. "Immunologically Active Biomaterials for Cancer Therapy." In Current Topics in Microbiology and Immunology, 279–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/82_2010_69.

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Rundqvist, Helene, and Randall S. Johnson. "Hypoxia and Metastasis in Breast Cancer." In Current Topics in Microbiology and Immunology, 121–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/82_2010_77.

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Roth, Anna, and Sven Diederichs. "Long Noncoding RNAs in Lung Cancer." In Current Topics in Microbiology and Immunology, 57–110. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/82_2015_444.

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Conference papers on the topic "Cancer – Microbiology"

1

García-Mena, Jaime, Fernando Hernández-Quiroz, Selvasankar Murugesan, Cristina Velazquez-Martínez, Loan Villalobos-Flores, Otoniel Maya-Lucas, Alberto Piña-Escobedo, et al. "The Vaginal and Fecal Microbiota associated to cervical cancer development in a mice model." In 1st International Electronic Conference on Microbiology. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ecm2020-07098.

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Sahara, A. L., F. Ibrahim, M. N. Massi, and A. Yasmon. "Association of Chlamydia trachomatis, Mycoplasma spp., Ureaplasma urealyticum and U. parvum with Human Papillomavirus in Patients with Cervical Cancer." In 10th International Seminar and 12th Congress of Indonesian Society for Microbiology (ISISM 2019). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/absr.k.210810.003.

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