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1

United States. Congress. Senate. Committee on Environment and Public Works. Cancer clusters in Long Island, NY: Field hearing before the Committee on Environment and Public Works, United States Senate, One Hundred Seventh Congress, first session on assessing the potential links between environmental contamination and chronic diseases, June 11, 2001, Garden City, NY. Washington: U.S. G.P.O., 2003.

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2

Oversight on disease clusters and environmental health: Hearing before the Committee on Environment and Public Works, United States Senate, One Hundred Twelfth Congress, first session, March 29, 2011. Washington: U.S. Government Printing Office, 2014.

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3

Strengthening Protections for Children and Communities from Disease Clusters Act: Report together with minority views (to accompany S. 76) (including cost estimate of the Congressional Budget Office). Washington, D.C: U.S. G.P.O., 2012.

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4

Advances in cancer research: Clusterin. London: Academic, 2009.

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5

Aldrich, Tim E. Evaluation of cancer cluster reports in North Carolina. [Raleigh, N.C.]: N.C. Dept. of Environment, Health, and Natural Resources, Division of Statistics and Information Services, Center for Health and Environmental Statistics, 1991.

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6

Aldrich, Tim E. Evaluation of cancer cluster reports in North Carolina. [Raleigh, N.C.]: N.C. Dept. of Environment, Health, and Natural Resources, Division of Statistics and Information Services, Center for Health and Environmental Statistics, 1991.

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7

United States. Agency for Toxic Substances and Disease Registry. Pancreatic cancer cluster investigation of Livingston and Park County, Montana. Atlanta, Ga: [The Agency?, 1991.

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8

United States. Agency for Toxic Substances and Disease Registry. Division of Health Studies. Investigation of a cluster of pancreatic cancer deaths, Livingston and Park County, Montana. Atlanta, Ga: [The Agency, 1992.

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9

Fagin, Dan. Toms River: A small town, a cancer cluster, and the epic quest to expose pollution's hidden consequences. New York: Bantam Books, 2013.

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10

Toms River: A small town, a cancer cluster, and the epic quest to expose pollution's hidden consequences. New York: Bantam Books, 2013.

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11

Statistical methods for disease clustering. New York: Springer, 2010.

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12

Keefe, Ryan. Resource-constrained spatial hot spot identification. Santa Monica, CA: RAND, 2011.

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13

E, Alexander F., and Boyle P, eds. Methods for investigating localized clustering of disease. Lyon, France: International Agency for Research on Cancer, World Health Organization, 1996.

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14

1965-, Sullivan Thomas, ed. Resource-constrained spatial hot spot identification. Santa Monica, CA: RAND, 2011.

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15

Stewart, Alex G., Sam Ghebrehewet, and Richard Jarvis. Cancer and chronic disease clusters. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198745471.003.0017.

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Clusters of disease are often reported to health protection and a finger pointed at a nearby environmental hazard that is thought to be the cause. There is an expectation that the causal linkage will be clarified and action taken to alleviate the resulting anxiety and stop further ill health. Not all reported clusters are real, but all are worth some level of investigation to alleviate anxiety. However, investigating such clusters is not easy. Neither is investigating causal linkages to environmental issues. Using an example of childhood cancer and contaminated land, this chapter takes a stepwise, structured approach to the investigation, defining realistic outcomes and clear criteria to stop such an investigation. The vital role of a multi-agency incident team to integrate health studies and environmental investigations is explored. Readers will be able to undertake such investigations for themselves across a wide range of putative clusters of chronic diseases.
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16

Greenberg, Michael R., and Dona Schneider. Toward a Healthier Garden State: Beyond Cancer Clusters and COVID. Rutgers University Press, 2023.

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17

Greenberg, Michael R., and Dona Schneider. Toward a Healthier Garden State: Beyond Cancer Clusters and COVID. Rutgers University Press, 2023.

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18

Ward, Elizabeth. Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0024.

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This chapter provides an overview of the mechanisms by which cancer develops and the importance of exogenous exposures in cancer causation. It describes the magnitude of cancer as a public health problem in the United States and globally, highlights temporal trends in cancer rates in the United States and variations in global cancer burden by country, income level, and region. Laboratory methods for identification of potential carcinogens are reviewed with emphasis on recent developments in toxicogenomics and high-throughput screening. The classification system used by the International Agency for Research on Cancer (IARC) in evaluation of potential carcinogens is described, and data are presented on occupational and environmental agents classified as “carcinogenic to humans” or “probably carcinogenic to humans.” Specific occupational and environmental carcinogens are discussed in greater detail. Topics of interest to clinicians and public health practicioners include the evaluation of occupational and community cancer clusters, primary and secondary prevention of occupational cancer, and four case studies related to cancer prevention and control and risk communication in diverse occupational settings.
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19

Lehmann, Vicky, and Marrit A. Tuinman. Body Image Issues Across Cancer Types. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190655617.003.0005.

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Abstract: This chapter provides a broad overview of body image challenges experienced by cancer patients and survivors, first focusing on patient characteristics and common treatment side effects that can affect body image and then summarizing findings specific to certain clusters of diagnoses. Research in the area of body image and cancer has largely focused on patients with breast cancer. A growing body of research also recognizes the negative impact of altered appearance and functioning on body image outcomes of patients with sexual organ-related, gastrointestinal, head and neck, skin, and other cancers. Body image is typically evaluated within the context of a single type of cancer and rarely compared across different types. This chapter proposes a visibility-stability model as a conceptual framework to facilitate understanding of the impact of cancer on body image across cancer types. This framework further considers functional body changes and survivors’ subjective evaluations as core components.
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20

US GOVERNMENT. Cancer Clusters in Long Island, NY: Field Hearing Before the Committee on Environment and Public Works, United States Senate, One Hundred Seventh Cong. Government Printing Office, 2003.

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21

Reid, Harry. Cancer Clusters in Long Island, Ny: Field Hearing Before the Committee on Environment And Public Works, U.s. Senate. Diane Pub Co, 2001.

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22

Ajithkumar, Thankamma, Ann Barrett, Helen Hatcher, and Natalie Cook. Palliative care. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235636.003.0020.

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Pain management 640Nausea and vomiting 646Malignant bowel obstruction 649Constipation 650Diarrhoea 651Hiccups 652Depression 654Delirium 656Oral care 657Cancer-related fatigue 658Cancer cachexia 659Breathlessness 660Cough 661Haemoptysis 662Symptom clusters 663End of life care 664In general, cancer pain management should be focused on the three-step WHO analgesic ladder for cancer pain relief (Ventafridda et al. ...
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23

Clusterin. Academic Press, 2009.

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24

Bettuzzi, Saverio, and Sabina Pucci. Clusterin. Elsevier Science & Technology Books, 2009.

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25

Plutynski, Anya. Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199967452.003.0002.

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Is cancer one or many? If many, how many diseases is cancer, exactly? I argue that this question makes a false assumption; there is no single “natural” classificatory scheme for cancer. Rather, there are many ways to classify cancers, which serve different predictive and explanatory goals. I consider two philosophers’ views concerning whether cancer is a natural kind, that of Khalidi, who argues that cancer is the closest any scientific kind comes to a homeostatic property cluster kind, and that of Lange, whose conclusion is the opposite of Khalidi’s; he argues that cancer is at best a “kludge” and that advances in molecular subtyping of cancer hail the “end of diseases” as natural kinds. I consider several alternative accounts of natural or “scientific” kinds, the “simple causal view,” the “stable property cluster” view, and “scientific kinds,” and argue that the diverse aims of cancer research require us to embrace a much more pluralistic view.
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26

Bettuzzi, Saverio, and Sabina Pucci. Clusterin, Part B. Elsevier Science & Technology Books, 2009.

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27

Goldstein, Inge F., and Martin Goldstein. How Much Risk? Oxford University Press, 2002. http://dx.doi.org/10.1093/oso/9780195139945.001.0001.

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An excellent critical analysis and scientific assessment of the nature and actual level of risk leading environmental health hazards pose to the public. Issues such as radiation from nuclear testing, radon in the home, and the connection between electromagnetic fields and cancer, environmental factors and asthma, pesticides and breast cancer and leukemia clusters around nuclear plants are discussed, and how scientists assess these risks is illuminated. This book will enable readers to better understand environmental health issues, and with the proper scientific understanding, make informed, rational decisions about them.
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28

McFarland, Daniel, and Jimmie C. Holland. Distress, Adjustment, and Anxiety Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190491857.003.0001.

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This chapter deals with anxiety in cancer patients as it presents in distress, adjustment disorders, and formal anxiety disorders. The implementation of distress screening is now used to capture patients who are at risk of a range of psychological complications that are addressed in this book. “Distress” covers the range of responses from the “normal” distress of fear, worry, and anxiety to formal defined psychiatric disorders. Adjustment disorders are the mildest level of psychiatric disorder occurring in relation to the stressor of a diagnosis with cancer or its treatment. Formal anxiety disorders typically antedate the cancer diagnosis and have clear symptom clusters defined by formal criteria. These include generalized anxiety disorder, panic disorder, phobias (e.g., needle, claustrophobia) and anxiety disorder due to another medical condition. These disorders require careful medical and psychiatric workup to identify potential etiologic stressors, agents, or responsible medical conditions.
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29

Risk and Adaptation in a Cancer-Cluster Town. Rutgers University Press, 2023.

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30

Hui, David. Early Palliative Care for Patients with Advanced Cancer (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0002.

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This chapter discusses the Zimmermann trial, a large partially blinded, cluster randomized controlled trial of routine oncology care with or without early routine referral to palliative care. This landmark study found that early palliative care involvement was associated with improved quality of life, symptom burden and satisfaction among patients with advanced cancer. This chapter describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case to illustrate some key points around palliative care referral.
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31

Paiva, Carlos Eduardo, and André Filipe Junqueira dos Santos. Liverpool Care Pathway for Hospitalized Cancer Patients (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0044.

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The Liverpool Care Pathway (LCP) for patients who are dying was developed in the UK with the aim of transferring the best practice of hospices to hospitals. In this chapter, an important cluster randomized trial is dissected. Sixteen Italian general medicine hospital wards were randomly assigned to implement the Italian LCP (LCP-I) program or standard health care practice. The results of this trial did not show a significant difference in the overall quality of end-of-life care between the wards in which the LCP-I program was implemented and the control wards (primary aim). Of the nine secondary outcomes investigated, only two showed significant improvements. At the end of the chapter, the authors present a real situation where one hospital CEO, after identifying end-of-life care as a weakness of his institution, evaluates the possibility to implement the LCP or to build a new physical structure dedicated to palliative care.
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32

Fancourt, Daisy. Fact file 5: Neurology. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198792079.003.0018.

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Neurology focuses on diagnosing and treating conditions affecting the nervous system, which encompasses the brain and peripheral nervous system (involving the nerves and nerve cell clusters that connect the brain to the limbs and organs) and the muscular system. Some neurological conditions are present from birth, such as cerebral palsy; while some develop during childhood, such as Duchenne muscular dystrophy; and others typically affect older people, such as Alzheimer’s and Parkinson’s diseases. Neurology also deals with acquired brain injuries, strokes, and cancers affecting the brain and spine....
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33

Klein, Jessica, and Christopher Oakley. Migraine and Headache in Children. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0075.

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Headache is the number one reason for referral to a pediatric neurologist, and these children report a quality of life similar to children with cancer and arthritis; therefore this concern warrants particular attention to accurately diagnose, evaluate, and treat. Of the primary headache disorders, tension is the most common, whereas migraine is often the most disabling. Other examples of childhood headaches include migraine precursors, cluster, trigeminal autonomic cephalalgias, and neuralgias. The aim of this chapter is to define migraine and other primary headache disorders of childhood, discuss the neurobiology of headache, and review clinical presentation, diagnostic workup, and treatment.
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34

Sklar, Marisa, Joanna C. Moullin, and Gregory A. Aarons. Study Design, Data Collection, and Analysis in Implementation Science. Edited by David A. Chambers, Wynne E. Norton, and Cynthia A. Vinson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190647421.003.0006.

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This chapter provides an introduction to study design, data collection, and analysis in implementation science. Although the randomized controlled trial is frequently employed in implementation science, a number of alternatives are relied on for addressing the unique challenges present. Alternatives include the cluster randomized control trial, roll-out designs such as the stepped wedge, cumulative trial, and effectiveness–implementation hybrid designs. Data collection and data analytic techniques must also address the unique challenges present in implementation science. Often, implementation occurs over time, often, across complex, multilevel contexts. Implementation scientists frequently utilize mixed, qualitative, and quantitative methodologies for collecting, analyzing, and interpreting data. Data represent the outer context of service systems and the inner context of organizations such that the data are often nested and hierarchical in nature. This chapter highlights the previously mentioned topics, particularly as they relate to currently funded implementation studies focused on the cancer control continuum.
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