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Relevant bibliographies by topics / Cancer cells metabolism

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Dissertations / Theses

Academic literature on the topic 'Cancer cells metabolism'

Author: Grafiati

Published: 14 March 2023

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Dissertations / Theses on the topic "Cancer cells metabolism"

1

Simon, Molas Helga. "Exploring the regulation and function of TIGAR in cancer cells." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667414.

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The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) gene was described in 2006 by Dr. Karen Vousden's group in response to the induction of the tumour suppressor gene p53. Since then, numerous studies have focused on clarifying the role of this gene in the metabolism of tumour cells. TIGAR was initially described as an enzyme with bisphosphatase activity on fructose-2,6-bisphosphate, a key metabolite in the positive allosteric regulation of phosphofructokinase-1, which catalyses a key reaction in glycolysis. Through this bisphosphatase activity, TIGAR reduces the levels of fructose-2,

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2

Board, Mary. "A study of energy metabolism in neoplastic cells." Thesis, University of Oxford, 1990. http://ora.ox.ac.uk/objects/uuid:d3e13e31-3fe8-4cd8-ad71-50d4e7df4d27.

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3

Vermeersch, Kathleen A. "Systems-level characterization of ovarian cancer metabolism." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54258.

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The purpose of this thesis was to characterize cancer metabolism in vitro using epithelial ovarian cancer as a model on an untargeted, systems-level, basis with particular attention paid to the difference between cancer stem cell metabolism and cancer cell metabolism. Two-dimensional gas chromatography coupled to mass spectrometry was used to measure the metabolite profiles of the ovarian cancer and cancer stem cell lines under normal baseline conditions and also under chemotherapeutic and environmental perturbations. These two cell lines exhibited significant metabolic differences under norma

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4

Hjertman, Magnus. "Protein modification with hydrophobic prenyl groups in malignant cells /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-7349-063-6/.

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5

Ross, Helen L. "The metabolism of benzo(a)pyrene in human cells." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253019.

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6

Pyne, Emily Seton. "The Impact of Stromal Cells on the Metabolism of Ovarian Cancer Cells in 3D Culture." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/74931.

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Academic: Ovarian cancer is the leading cause of death among female gynecologic cancers. Current treatments include surgical debulking, and chemotherapy. However, better interventions are needed to reduce the mortality rate of metastatic disease. Ovarian cancer cells have displayed the ability to aggregate and form 3D homogeneous and heterogeneous spheroids, which can function as micrometastases. Ovarian cancer spheroids survive independently prior to adhering to an endothelial tissue. Since aggregation has been shown to provide a survival advantage to the spheroids and increased their aggres

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7

Wang, Feng. "Interaction between pancreatic cancer and beta cells : intraislet significance of islet amyloid polypeptide /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3300-6/.

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8

Maddula, Sasidhar [Verfasser]. "Cell cycle phase specific metabolism of colon cancer cells: a metabolome study / Sasidhar Maddula." München : Verlag Dr. Hut, 2011. http://d-nb.info/1018980911/34.

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9

E, Pranzini. "Metabolic reprogramming of colorectal cancer cells resistant to 5-FU." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1095546.

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Metabolic rearrangements are essential to satisfy the different needs of cancer cells during tumorigenesis. Recent studies highlighted a role for such metabolic reprogramming in adaptation to therapies and chemo-resistance development. 5-fluorouracil (5-FU) is an antimetabolite drug widely used as a first-line treatment for colorectal cancer. Despite several advantages of 5-FU, its clinical application is still greatly limited, due to the acquisition of drug resistance. In the first part of this thesis, we illustrate the role of micro RNAs (miRNAs) in reprogramming colon cancer cells toward

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10

Bellio, Chiara. "Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424111.

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Ovarian cancer is the fourth leading cause of cancer-related death in women and the leading cause of gynecologic cancer death. Moreover, it is regarded as a therapy resistant tumor, because it shows the formation of more aggressive recurrence of the primary tumor as a result of chemotherapy. This chemo-resistance is thought to be related to the presence of the Cancer Stem Cells (CSC). Tumor cells are characterized by a high glycolytic metabolism even in the presence of oxygen, the so-called Warburg effect; however, it is unclear whether this condition is also shared by CSC. We identified ov

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