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1

Leong, Stanley P. L., ed. From Local Invasion to Metastatic Cancer. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-087-8.

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2

Brunson, Kenneth W., ed. Local Invasion and Spread of Cancer. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1093-5.

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3

Mareel, Marc M. Mechanisms of invasion and metastasis. Boca Raton: CRC Press, 1991.

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4

1959-, Mikkelsen Tom, ed. Brain tumor invasion: Biological, clinical, and therapeutic considerations. New York: Wiley-Liss, 1998.

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5

Brown, James Stephen. Invasion of the mandible in oral cancer. Birmingham: University of Birmingham, 1994.

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6

Kagan, A. Robert, and Richard J. Steckel, eds. Practical Approaches to Cancer Invasion and Metastases. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84885-8.

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7

Wells, Alan, ed. Cell Motility in Cancer Invasion and Metastasis. Berlin/Heidelberg: Springer-Verlag, 2006. http://dx.doi.org/10.1007/b103440.

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8

Heino, Jyrki, and Veli-Matti Ka ha ri. Cell invasion. Georgetown, Tex: Landes Bioscience, 2002.

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9

S, Lakshmi M., ed. The genetics of cancer: Genes associated with cancer invasion, metastasis, and cell proliferation. San Diego: Academic Press, 1997.

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10

Mark, Scholz, ed. Invasion of the prostate snatchers: No more unnecessary biopsies, radical treatment or loss of sexual potency. New York: Other Press, 2010.

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11

Leong, Stanley P. L. From local invasion to metastatic cancer: Involvement of distant sites through the lymphovascular system. New York: Humana, 2009.

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12

Blum, Ralph. Invasion of the prostate snatchers: No more unnecessary biopsies, radical treatment or loss of sexual potency. New York: Other Press, 2010.

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13

Bassi, PierFrancesco, and Francesco Pagano, eds. Invasive Bladder Cancer. London: Springer London, 2007. http://dx.doi.org/10.1007/978-1-84628-377-2.

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14

Greene, Frederick L., and B. Todd Heniford, eds. Minimally Invasive Cancer Management. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-1238-1.

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15

Greene, Frederick L., and B. Todd Heniford, eds. Minimally Invasive Cancer Management. New York, NY: Springer New York, 2001. http://dx.doi.org/10.1007/978-1-4757-3444-7.

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16

Goonewardene, Sanchia S., Karen Ventii, Amit Bahl, Raj Persad, Hanif Motiwala, and David Albala. Management of Muscle Invasive Bladder Cancer. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57915-9.

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17

Goonewardene, Sanchia S., Raj Persad, Hanif Motiwala, and David Albala. Management of Non-Muscle Invasive Bladder Cancer. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-28646-0.

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18

Cuesta, Miguel A., ed. Minimally Invasive Surgery for Upper Abdominal Cancer. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-54301-7.

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19

Fitzgerald, Rebecca C. Pre-invasive disease: Pathogenesis and clinical management. New York: Springer, 2011.

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20

Pardee, Joel D., and Anthony M. C. Brown. Cancer Invasion and Metastasis. Morgan & Claypool Life Science Publishers, 2011.

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21

Denoix, P. Mechanisms of Invasion in Cancer. Springer, 2012.

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22

Denoix, P. Mechanisms of Invasion in Cancer. Springer, 2012.

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23

Bagrodia, Aditya, and Yair Lotan. Low and intermediate risk non-muscle-invasive bladder cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0076.

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Bladder cancer is a common disease that affects more males than females. Most bladder tumours are histologically typed as urothelial cell carcinoma, and these are best divided into cancers invading the muscularis propria and non-invasive malignancies confined to the bladder. The latter are the majority of cancers and include low risk, indolent cancers that may recur within the bladder but not progress to invasion or metastases, and a proportion that subsequently progress to muscle invasion. The risk of intravesical recurrence or progression to invasion from a non-invasive bladder cancer can be stratified as low, intermediate, and high using various pathological factors (such as tumour grade, stage, size, multiplicity, and the presence of carcinoma in situ). In this chapter, we will give an overview of bladder cancer and focus upon tumours at low or intermediate risk of developing future progression to invasion.
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24

Heino, Jyrki. Cell Invasion. Taylor & Francis Group, 2002.

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25

Heino, Jyrki. Cell Invasion. Taylor & Francis Group, 2002.

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26

Meijer, Richard P., Alexandre R. Zlotta, and Bas W. G. van Rhijn. Bladder cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0077.

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High-grade non-muscle-invasive bladder cancer (HG-NMIBC) represents the most aggressive spectrum of this non-invasive cancer. This collective term includes all high-grade NMI urothelial carcinoma (UC), such as those without invasion (pTa), those with lamina propria invasion (pT1), and those that are only/have concomitant carcinoma in situ (CIS; pTis). These cancers have a high risk for intravesical recurrence (around 46–78% at five years) and progression (between 6–45% at five years) to muscle-invasive bladder cancer (MIBC). As with all UC, their presentation can be with visible haematuria or irritative lower urinary tract symptoms. The latter are common in patients with CIS. CIS may be detected in isolation (so-called primary CIS) or with a coexisting UC elsewhere (termed concomitant CIS). While urinary cytology has a moderate sensitivity and high specificity (>90%) for the detection of HG-NMIBC, cystoscopy is the most important diagnostic tool.
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27

W, Brunson Kenneth, ed. Local invasion and spread of cancer. Dordrecht: Kluwer Academic Publishers, 1989.

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28

Brunson, Kenneth W. Local Invasion and Spread of Cancer. Springer, 2012.

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29

Brunson, Kenneth W. Local Invasion and Spread of Cancer. Springer, 2011.

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30

Local Invasion and Spread of Cancer. Springer, 2011.

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31

Zehnder, Pascal, and George N. Thalmann. Muscle-invasive bladder cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0078.

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In the United Kingdom, >4,000 people die of bladder cancer every year. This reflects around one-third of affected patients and occurs in those with primary metastatic disease, with invasion at presentation, and in persons whose tumour progresses to invasion from non-invasive disease. The outcome from invasive cancers has not dramatically altered over the last 30 years, due to a lack of screening programmes, a lack of advances in treatment, and the fact that many patients present with tumours at an advanced stage. Around 50% of patients with invasive disease die from bladder cancer despite radical treatment, suggesting the disease is metastatic at presentation. Cure is rarely possible in patients with locally advanced tumours and lymph node metastases. Therapeutic options include systemic chemotherapy and salvage radical treatment for responders or palliation. Following radical cystectomy for cancer, patients require lifelong follow-up for both oncologic and functional reasons.
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32

Wells, Alan. Cell Motility in Cancer Invasion and Metastasis. Springer, 2010.

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33

1950-, Brodt Pnina, ed. Cell adhesion and invasion in cancer metastasis. Austin: R.G. Landes Co., 1996.

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34

Wells, Alan. Cell Motility in Cancer Invasion and Metastasis. Springer, 2006.

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35

(Editor), Tom Mikkelsen, Rolf Bjerkvig (Editor), Ole Didrik Laerum (Editor), and Mark L. Rosenblum (Editor), eds. Brain Tumor Invasion: Biological, Clinical, and Therapeutic Considerations. Wiley-Liss, 1998.

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36

Liotta, L. A., and I. R. Hart. Tumor Invasion and Metastasis. Springer Netherlands, 2012.

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37

Liotta, L. A., and I. R. Hart. Tumor Invasion and Metastasis. Springer, 2012.

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38

Sherbet, Gajanan V., and M. S. Lakshmi. Genetics of Cancer: Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation. Elsevier Science & Technology Books, 1997.

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39

Wells, Alan. Cell Motility in Cancer Invasion and Metastasis (Cancer Metastasis - Biology and Treatment). Springer, 2006.

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40

Brodt, P. Cell Adhesion and Invasion Mechanisms in Cancer Metastasis. Springer, 1996.

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41

Research at NCI on cancer invasion and metastasis. [Bethesda, Md.?]: National Cancer Institute/Office of Cancer Communications, 1985.

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42

Brodt, Pnina. Cell Adhesion and Invasion Mechanisms in Cancer Metastasis. Landes Bioscience, 1996.

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43

Heino, Jyrki, and Veli-matti Kahari. Cell Invasion (Medical Intelligence Unit). Landes Bioscience, 2002.

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44

Shields, J. A., K. Murray, S. Gupta, J. E. Marks, M. J. Miller, N. Kaufman, H. Reiter, et al. Practical Approaches to Cancer Invasion and Metastases: A Compendium of Radiation Oncologists’ Responses to 40 Histories. Springer, 2012.

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45

Blum, Ralph, and Mark Scholz. Invasion of the Prostate Snatchers: An Essential Guide to Managing Prostate Cancer for Patients and Their Families. Other Press, LLC, 2011.

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46

Proteinases in Inflamation and Tumour Invasion. Walter de Gruyter & Co, 1986.

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47

S, Aron Bernard, Kagan A. Robert 1936-, and Steckel Richard J. 1936-, eds. Practical approaches to cancer invasion and metastases: A compendium of radiation oncologists' responses to 40 histories. Berlin: Springer-Verlag, 1994.

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48

(Editor), Liliana Ossowski, and Robert M. Lopez (Editor), eds. Proteolytic Enzymes in Cancer Invasion (Journal - Enzyme and Protein , Vol 49, No 1-3). S Karger Pub, 1996.

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49

Leong, Stanley P. L. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System. Humana, 2014.

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50

Linehan, Rasha. The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer. 2003.

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