Relevant bibliographies by topics / Cancellous bone defects

Academic literature on the topic 'Cancellous bone defects'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2022

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Journal articles on the topic "Cancellous bone defects"

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Dorea, H. C., H. D. Cantwell, R. Read, L. Armbrust, R. Pool, J. K. Roush, C. Boyle, and R. M. McLaughlin. "Evaluation of healing in feline femoral defects filled with cancellous autograft, cancellous allograft or Bioglass." Veterinary and Comparative Orthopaedics and Traumatology 18, no. 03 (July 2005): 157–68. http://dx.doi.org/10.1055/s-0038-1632947.

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SummaryCancellous bone grafting is a widely accepted technique in human and veterinary orthopaedic surgery. However, the use of autogenous bone graft is limited by the additional surgical time required to harvest the graft, the morbidity associated with the donor site, and the limited availability of cancellous bone, especially in feline patients. Various allografts and bone graft substitutes are available commercially but have not been fully evaluated for efficacy in the cat. The purpose of this study was to compare the incorporation of autogenous and allogenous cancellous bone graft and Bioglass®, a synthetic bone graft substitute, in femoral defects in cats. Four (4.0 mm diameter) defects were created in the lateral diaphyseal cortex of the left femur with an orthopaedic drill. In each femur, one of the cortical defects was filled with autogenous cancellous graft (harvested from the tibia), one was filled with allogenic cancellous graft, and one was filled with Bioglass. The fourth defect remained unfilled. Graft incorporation within the femoral defects was evaluated by radiographic evaluation every two weeks. Six weeks after the grafting procedure, the cats were euthanatized and high detailed radiography, dual energy X-ray absorptiometry (DEXA), histopathology and histomorphometry of the defects were performed. Satisfactory bone healing was observed within all of the defects.
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Díaz-Bertrana, C., P. Lafuente, P. Fontecha, I. Durall, and J. Franch. "Beta-tricalcium phosphate as a synthetic cancellous bone graft in veterinary orthopaedics." Veterinary and Comparative Orthopaedics and Traumatology 19, no. 04 (October 2006): 196–204. http://dx.doi.org/10.1055/s-0038-1633001.

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SummaryThe clinical use of β-tricalcium phosphate (β-TCP) as a synthetic cancellous bone graft in veterinary orthopaedics is herein reported. The retrospective study was based on 13 clinical cases belonging to 11 dogs and one cat. The weights of the dogs ranged from 3.4 to 48 kg. One female cat weighing 3.5 kg completed the study. The clinical cases were six arthrodeses (four carpal, two tarsal), one hypertrophic non-union (femur), one atrophic non-union (metacarpal bones) and five long-bone fractures (two femurs, one tibia, two radii) possessing subcritical-sized bone defects. The β-TCP used in this study was presented as irregular interconnected-porous granules and was placed in the bone defects after mixing it with fresh blood. Bone healing was achieved at between eight and 12 weeks in all clinical cases except for the case of the chronic atrophic nonunion in which only one of the four metacarpal bones healed. In the 12 successful cases, the bone defect grafted with β-TCP showed a radiological bone ingrowth of 100% (10 cases), 90% (one case) and 75% (one case). The complete lack of tissue adverse effects in our series, and the good defect healing, allows us to hypothesise that β-TCP can be successfully used as a synthetic bone graft in bone defects with good local biological conditions and where osteoconduction is especially needed for assuring a structural scaffold for newbone ingrowth. When, in addition to osteoconduction, osteoinduction and osteogenesis are necessary for defect healing, the fresh cancellous bone graft remains the gold standard in veterinary orthopaedics.
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Verboket, René D., Tanja Irrle, Yannic Busche, Alexander Schaible, Katrin Schröder, Jan C. Brune, Ingo Marzi, Christoph Nau, and Dirk Henrich. "Fibrous Demineralized Bone Matrix (DBM) Improves Bone Marrow Mononuclear Cell (BMC)-Supported Bone Healing in Large Femoral Bone Defects in Rats." Cells 10, no. 5 (May 19, 2021): 1249. http://dx.doi.org/10.3390/cells10051249.

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Regeneration of large bone defects is a major objective in trauma surgery. Bone marrow mononuclear cell (BMC)-supported bone healing was shown to be efficient after immobilization on a scaffold. We hypothesized that fibrous demineralized bone matrix (DBM) in various forms with BMCs is superior to granular DBM. A total of 65 male SD rats were assigned to five treatment groups: syngenic cancellous bone (SCB), fibrous demineralized bone matrix (f-DBM), fibrous demineralized bone matrix densely packed (f-DBM 120%), DBM granules (GDBM) and DBM granules 5% calcium phosphate (GDBM5%Ca2+). BMCs from donor rats were combined with different scaffolds and placed into 5 mm femoral bone defects. After 8 weeks, bone mineral density (BMD), biomechanical stability and histology were assessed. Similar biomechanical properties of f-DBM and SCB defects were observed. Similar bone and cartilage formation was found in all groups, but a significantly bigger residual defect size was found in GDBM. High bone healing scores were found in f-DBM (25) and SCB (25). The application of DBM in fiber form combined with the application of BMCs shows promising results comparable to the gold standard, syngenic cancellous bone. Denser packing of fibers or higher amount of calcium phosphate has no positive effect.
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Schneppendahl, J., T. T. Lögters, M. Sager, M. Wild, M. Hakimi, J. Windolf, J. P. Grassmann, and P. Jungbluth. "Treatment of a diaphyseal long-bone defect with autologous bone grafts and platelet-rich plasma in a rabbit model." Veterinary and Comparative Orthopaedics and Traumatology 28, no. 03 (2015): 164–71. http://dx.doi.org/10.3415/vcot-14-05-0079.

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Summary Introduction: Large bone defects are a therapeutic challenge to surgeons and are often associated with a high morbidity. The use of autologous cancellous bone graft represents an essential therapeutic option and is considered the gold standard. However, the use of platelet-rich plasma (PRP) for improving bone defect healing has been discussed controversially. The aim of this study was to evaluate the treatment of a diaphyseal long-bone defect in a rabbit model with a combination of PRP and autologous cancellous bone. Material and methods: A monocortical long-bone defect in the radial diaphysis of 24 New Zealand white rabbits was filled either with autologous cancellous graft as a control group or with autologous cancellous graft combined with autologous PRP. Histomorphometrical and radiological analysis as well as quantification of platelets and growth factors were performed. The animals were euthanatized after three and six weeks according to the study arms. Results: A significant improvement in bone healing was observed histomorphometrically in the PRP group in the central area of the defect zone (p <0.01) as well as the cortical defect zone (p <0.01). The radiological findings were in accordance with the histomorphometrical results. Comparing native blood and PRP, an enrichment of growth factors and platelets was detectable in the PRP. Conclusion: Within this animal study, the combination of PRP and autologous cancellous bone grafts improved bone healing significantly compared to the sole application of autologous bone. Therefore, further efforts should be initiated to establish the composite of PRP and autologous bone for bone healing disorders in clinical use.
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Zheng, Chong, Hai-yang Ma, Yin-qiao Du, Jing-yang Sun, Ji-wei Luo, Dong-bin Qu, and Yong-gang Zhou. "Finite Element Assessment of the Screw and Cement Technique in Total Knee Arthroplasty." BioMed Research International 2020 (October 15, 2020): 1–7. http://dx.doi.org/10.1155/2020/3718705.

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Background. The screw and cement technique is a convenient method used to rebuild medial tibial plateau defects in primary total knee arthroplasty (TKA). The objective of this study was to perform a finite element assessment to determine the effect of different numbers of screws on the stability of TKA and to determine whether differences exist between two different insertion angles. Method. Six tibial finite element models with defects filled with screws and cement and one model with defects filled only with cement were generated. Contact stresses on the surface of cancellous bone in different areas were calculated. Results. Compared to the cement-only technique, the stress on the border of cancellous bone and bone cement decreased by 10% using the screw and cement technique. For bone defects with a 12% defect area and a 12-mm defect depth, the use of 1 screw achieved the greatest stability; for those with a 15% defect area and a 20-mm defect depth, 2 screws achieved the greatest stability. Conclusions. (1) The screw and cement technique is superior to the bone cement-only technique. For tibial defects in which the defect area comprises a large percentage but the depth is less than 5 mm, the screw and cement technique is recommended. (2) Vertical screws can achieve better stability than oblique screws. (3) Screws should be used in moderation for different defects; more is not always better.
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Murata, Koichi, Shunsuke Fujibayashi, Bungo Otsuki, Takayoshi Shimizu, and Shuichi Matsuda. "Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite." Asian Spine Journal 14, no. 6 (December 31, 2020): 808–13. http://dx.doi.org/10.31616/asj.2019.0310.

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Study Design: Retrospective study.Purpose: This study aimed to assess the effect of refilling with hydroxyapatite/collagen (HAp/Col) composite on an iliac crest defect after spinal fusion.Overview of Literature: The use of iliac crest bone graft has been the gold standard in spinal fusion for a long time because of its biological and non-immunologic properties. Few reports have addressed how bone defects recover after iliac crest bone harvest following spinal fusion.Methods: Cancellous bone was collected from the anterior iliac crest during lateral interbody fusion (LIF), and the bone void of the ilium was refilled with a porous HAp/Col composite. We assessed bone recovery using computed tomography (CT). From the 74 patients who underwent LIF between January 2015 and December 2016, we included 49 patients whose iliac crest could be evaluated using CT at 3 months and 1 year after the surgery.Results: Bone defects decreased in a time-dependent manner after the surgery. Cortical closure was observed in 28.5% of the cases 3 months after the surgery; at 1 year postoperatively, 95.9% of the patients had cortical closure. Complete repair of the cancellous bone was achieved in 57.1% of the patients at 3 months after the surgery and in 95.9% at 1 year after the surgery. There were no significant hematomas, infections, iliac crest fractures, or soft tissue herniation.Conclusions: Radiographic recovery of cortical and cancellous bone defects was achieved with high probability via refilling with HAp/Col composite over the 1-year period.
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Dogan, E., and Z. Okumus. "Cuttlebone used as a bone xenograft in bone healing." Veterinární Medicína 59, No. 5 (July 15, 2014): 254–60. http://dx.doi.org/10.17221/7519-vetmed.

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This study was conducted to examine the potential of cuttlebone xenograft in the healing of bone using radiography and histology for a period of 24 weeks. One hundred and five New Zealand male rabbits with radius defects in the metaphyseal region were divided into five groups treated with cuttlebone, demineralized bone matrix, bovine cancellous graft, and tricalcium phosphate. The control was no treatment. Clinical, radiological, biochemical and histological evaluations were made 1, 2, 3, 4, 6, 12, and 24 weeks after surgery. Physiological measurements (body temperature, heart rate, and respiratory rate) were not affected by the treatments. The radiological score was greatest in the demineralised bone matrix and tricalcium phosphate groups (score of 8), followed by the bovine cancellous graft (score of 6), cuttlebone (score of 6), and control groups (score of 5). The histological score was greatest in the tricalcium phosphate group (score of 55), followed by the cuttlebone (score of 50), bovine cancellous graft (score of 48), demineralized bone matrix (score of 44) and control groups (score of 42). Oxidative enzyme activities were not different across the treatments. The lack of reinfection and infection responses and faster bone union highlight the potential of cuttlebone xenograft in orthopaedic surgery. &nbsp;
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Borghetti, Alain, Giséle Novakovitch, Francis Louise, Didier Simeone, and Jean Fourel. "Cryopreserved Cancellous Bone Allograft in Periodontal Intraosseous Defects." Journal of Periodontology 64, no. 2 (February 1993): 128–32. http://dx.doi.org/10.1902/jop.1993.64.2.128.

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Singh, Luthra Jatinder, and Salim A. L. Habsi. "Biological Reconstruction of Varus Deformity in Primary Total Knee Replacement Using Bone Graft and Description of a New Technique." Journal of Orthopaedics, Trauma and Rehabilitation 25, no. 1 (June 1, 2018): 69–72. http://dx.doi.org/10.1016/j.jotr.2017.11.001.

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Peripheral bony defects of the tibia can be seen in patients with osteoarthritis of the knee. These defects must be corrected at the time of total knee replacement to ensure correct placement and alignment of the components. We describe a new technique for correcting large tibial defect by using bone graft, where the uncontained defects were converted to contained defects using bone graft and the contained defect was impacted with cancellous bone. Between 2006 and 2010, 48 cases of primary total knee arthroplasty were reconstructed using autologous bone graft. Of 48 cases, five cases had large tibial defect and were treated with the new technique. Collapse was seen in one knee at 5 months postoperative. The rest of the patients showed improvement in total knee score and limb alignment. We now use this technique to treat large tibial defect during total knee replacement.
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Aspenberg, P., J. Wittbjer, and K. G. Thorngren. "Bone matrix and marrow versus cancellous bone in rabbit radial defects." Archives of Orthopaedic and Traumatic Surgery 106, no. 6 (October 1987): 335–40. http://dx.doi.org/10.1007/bf00456866.

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Dissertations / Theses on the topic "Cancellous bone defects"

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Low, Adrian Kah Wai Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "The molecular biology of cancellous bone defects and oestrogen deficiency fractures, in rodents; and the in vivo effects of acid on bone healing." Publisher:University of New South Wales. Clinical School - Prince of Wales Hospital, 2008. http://handle.unsw.edu.au/1959.4/42884.

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The management of significant bone defects, delayed and non-union of fractures can be extremely challenging. Development of specific treatment is hindered by an absence of information regarding the molecular events which regulate these processes. In this thesis, a bilateral cancellous bone defect model of the femur and tibia was developed in a rodent and the spatiotemporal profile of TGF-β, BMP 2 and 7, Smads 1, 4 and 5 characterised. Next, the capability of acid solution to augment healing was tested in both a bone defect and in a closed femoral fracture model. Finally, a long term oestrogen deficiency (OVX) rat model of postmenopausal osteoporosis was characterised and the spatiotemporal profiles of IGF-1, IGFR-1, MMP-1, MMP-3, MMP-9, MMP-13, TIMP-1, TIMP-2, BMP-2, BMP-4, BMP-7, TGF-β, Smad4, Smad7, VEGF, Flt-1, Ihh and FGF-2 were compared in femoral osteotomies between OVX and Sham groups. The bilateral cancellous defect model was successfully created with a number of advantages with which to recommend its use in future studies. TGF-β, BMP 2 and 7, Smads 1, 4 and 5 had characteristic spatiotemporal profiles during cancellous bone defect healing suggesting that they have a regulatory role. The results of the acid study were inconclusive and problems with substance delivery and maintenance at the desired site need to be addressed in the future to fully test this hypothesis. No significant differences were detected on histology or three-point mechanical testing between the fracture calluses of acid and control groups. In the final study, OVX rats after six months had significantly increased weight and decreased bone mineral density compared to their sham counterparts. A histological delay in osteotomy healing was observed in the OVX group but no significant differences on tensile testing were seen between OVX and Sham groups up to six weeks. Immunohistochemistry revealed that delayed healing may be due to the down-regulation of IGF-1, BMP-2, 4, and 7 and the up-regulation of MMP-3 in OVX compared to Sham groups. In conclusion, the results of this thesis give some insight into the molecular biology of bone defects and osteoporotic fractures. This information may also be useful in the development of specific treatments aimed at augmenting healing in bone defects and osteoporotic fractures.
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Tsao, Yi-Pin. "Effects of a mineralized human cancellous bone allograft in regeneration of mandibular class II furcation defects a thesis submitted in partial fulfillment ... for the degree of Master of Science in Periodontics ... /." 2005. http://catalog.hathitrust.org/api/volumes/oclc/67878289.html.

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Book chapters on the topic "Cancellous bone defects"

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Thorngren, K. G., P. Aspenberg, and J. Wittbjer. "Injectable Bone Graft in Rabbit Radius Defects: Influence of Demineralized Bone Matrix, Bone Marrow and Cancellous Bone." In Bone Transplantation, 214–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83571-1_38.

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Arts, J. J. C., J. W. M. Gardeniers, M. L. M. Welten, N. Verdonschot, B. W. Schreurs, and P. Buma. "TCP-HA Granules and Impacted Morselized Cancellous Bone Graft Mixes for Acetabular Reconstruction with the Bone Impaction Grafting Technique. A Loaded and Critical Sized Defect Model in the Goat." In Bioceramics 17, 869–72. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-961-x.869.

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Conference papers on the topic "Cancellous bone defects"

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Moghaddam, Narges Shayesteh, Mohammad Elahinia, Michael Miller, and David Dean. "Enhancement of Bone Implants by Substituting Nitinol for Titanium (Ti-6Al-4V): A Modeling Comparison." In ASME 2014 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/smasis2014-7648.

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Mandibular segmental defect reconstruction is most often necessitated by tumor resection, trauma, infection, or osteoradionecrosis. The standard of care treatment for mandibular segmental defect repair involves using metallic plates to immobilize fibula grafts, which replace the resected portion of mandible. Surgical grade 5 titanium (Ti-6Al-4V) is commonly used to fabricate the fixture plate due to its low density, high strength, and high biocompatibility. One of the potential problems with mandibular reconstruction is stress shielding caused by a stiffness mismatch between the Titanium fixation plate and the remaining mandible bone and the bone grafts. A highly stiff fixture carries a large portion of the load (e.g., muscle loading and bite force), therefore the surrounding mandible would undergo reduced stress. As a result the area receiving less strain would remodel and may undergo significant resorption. This process may continue until the implant fails. To avoid stress shielding it is ideal to use fixtures with stiffness similar to that of the surrounding bone. Although Ti-6Al-4V has a lower stiffness (110 GPa) than other common materials (e.g., stainless steel, tantalum), it is still much stiffer than the cancellous (1.5–4.5 GPa) and cortical portions of the mandible (17.6–31.2 GPa). As a solution, we offer a nitinol in order to reduce stiffness of the fixation hardware to the level of mandible. To this end, we performed a finite element analysis to look at strain distribution in a human mandible in three different cases: I) healthy mandible, II) resected mandible treated with a Ti-6Al-4V bone plate, III) resected mandible treated with a nitinol bone plate. In order to predict the implant’s success, it is useful to simulate the stress-strain trajectories through the treated mandible. This work covers a modeling approach to confirm superiority of nitinol for mandibular reconstruction. Our results show that the stress-strain trajectories of the mandibular reconstruction using nitinol fixation is closer to normal than if grade 5 surgical titanium fixation is used.
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Amerinatanzi, Amirhesam, Narges Shayesteh Moghaddam, Ahmadreza Jahadakbar, David Dean, and Mohammad Elahinia. "On the Effect of Screw Preload on the Stress Distribution of Mandibles During Segmental Defect Treatment Using an Additively Manufactured Hardware." In ASME 2016 11th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/msec2016-8840.

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The most common method for mandibular reconstructive surgery is the use of a Ti-6Al-4V fixation device and a fibular double barrel graft. This highly stiff fixation hardware (E = 112 GPa) often shields the bone graft (E = 20 GPa) from carrying the load, which may result in bone resorption. Highly stiff Ti-6Al-4V fixation hardware is also likely to concentrate stress in the fixation plate or at screw threads, possibly leading to hardware cracking or screw pull-out. As a solution for that, we have proposed and studied the effect of using a low stiffness, porous NiTi fixation device [1–4]. Although the stress in the fixation device is increased, using such low stiffness fixation hardware, is preferable to have an even higher stress on the graft in order to minimize the risk of resorption or hardware failure. We assume that preloading screws allows them to better engage the fixation hardware with the plate and the surrounding bone and causes an increased von Mises stress. The fixation device can be patient-specific and additively manufactured, such that the shape would match the outer surface of the cortical bone. In this study, we modeled a healthy cadaver mandible via CT-derived 3D surface data. The mandible was virtually resected in the molar region (M1−3). The model simulated the result of reconstructive surgery under the highest chewing loading regime (i.e., 526 N on first right molar tooth [5, 6]) where reconstruction was done with either Ti-6Al-4V fixation hardware or patient specific, stiffness-matched, porous NiTi fixation hardware. The calibration of the material properties for this simulation was done using experimentally obtained data (DSC and compression tests) of Ni-rich NiTi bulk samples. The analyzed term in the finite element analysis was stress distribution in the cortical and cancellous bone. Porous NiTi fixation devices were also produced using Selective Laser Melting (SLM) using the geometry of the aforementioned cadaver mandible. In this paper we have studied the effect of additional torque or preload on the performance of the fixation plates. The finite element analysis demonstrated that applying a preload to the screws increased the stress on the bone. Under similar levels of applied preload, the porous NiTi fixation device showed an increased level of von Mises stress in the bone, particularly in the graft. Additionally, the analysis indicated the higher level of stress on the bone surrounding the screws for the case of using NiTi, which could contribute to increasing screw stability. The fabricated patient-specific fixation hardware not only matched the shape of cortical bone but also contained the level of porosity that defines the appropriate modulus of elasticity.
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