Academic literature on the topic 'Canary seed proteins'
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Journal articles on the topic "Canary seed proteins"
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Mason, Emily, Lamia L’Hocine, Allaoua Achouri, Mélanie Pitre, and Salwa Karboune. "Health Promoting Bioactive Properties of Novel Hairless Canary Seed Flour after In Vitro Gastrointestinal Digestion." Foods 9, no. 7 (July 14, 2020): 932. http://dx.doi.org/10.3390/foods9070932.
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The bioactive properties and health-promoting effects of two novel yellow (C09052, C05041) and two brown (Calvi, Bastia) hairless canary seed (Phalaris canariensis L.) cultivars were investigated in comparison to two common cereal grains (wheat and oat). The cereal flours were digested using the standardized INFOGEST in vitro human gastrointestinal digestion model. The three-kilo dalton molecular weight cutoff (3 kDa MWCO) permeate of the generated digestates was assessed in vitro for their antioxidant, chelating, antihypertensive and antidiabetic activities. The results showed no significant differences in studied bioactivities between yellow and brown canary seed cultivars, except for antioxidant activity by the DPPH and chelating Fe2+ assays, where brown cultivars had higher activities. Canary seeds had superior or equivalent antioxidant activity than those from oat and wheat. The anti-hypertensive activity (Angiotensin-converting enzyme (ACE) inhibition) in yellow canary seed cultivars was significantly higher than that of oat and wheat, particularly for C09052 and Calvi varieties. Peptides exhibiting the highest antihypertensive activity from the permeate of the C09052 canary seed variety were further fractionated and identified by mass spectrometry. Forty-six peptides were identified belonging to 18 proteins from the Pooideae subfamily. Fourteen of the parent proteins were homologous to barley proteins. Peptides were analyzed in silico to determine potential bioactivity based on their amino acid composition. All 46 peptides had potential anti-hypertensive and anti-diabetic activities and 20 had potential antioxidant activity, thereby validating the in vitro assay data. Canary seed peptides also exhibited potential antiamnestic, antithrombotic, immunostimulating, opioid and neuro-activity, demonstrating important potential for health promoting effects, particularly against cardiovascular disease.
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Cai, Q., and M. R. Bullen. "Identification of timothy cultivars by SDS-PAGE analysis of seed storage proteins." Canadian Journal of Plant Science 72, no. 4 (October 1, 1992): 1215–22. http://dx.doi.org/10.4141/cjps92-148.
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SDS-PAGE analysis of seed proteins was carried out to identify the cultivars in the forage crop, timothy (Phleum pratense L.). Nineteen cultivars of timothy were examined. Among them five were from Europe and fourteen from North America. In total fifty protein bands were detected in mature seed extract by SDS-PAGE followed by Coomassie blue staining. Except for two pairs, all the cultivars were differentiated by SDS-PAGE analysis of seed storage proteins. In the electrophoretic profile, no protein bands were found to be specific either to European or to North American cultivars which is an indication of their genetic similarity. Twelve samples of cultivar Toro harvested from Alberta and Manitoba (Canada), Idaho and Minnesota (USA) were compared and no significant differences were found in their seed protein banding patterns, which suggests environmental stability of timothy seed proteins.Key words: SDS PAGE, timothy cultivar identification, seed storage proteins
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Khanal, Nityananda, Michael P. Schellenberg, and Bill Biligetu. "Agro-morphology and forage nutritive value of white prairie clover [Dalea candida(Michx.) Willd.] populations native to the Canadian prairies." Canadian Journal of Plant Science 98, no. 6 (December 1, 2018): 1234–44. http://dx.doi.org/10.1139/cjps-2017-0255.
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White prairie clover [Dalea candida (Michx.) Willd.] is native to the dry prairies and hillsides of the Northern Great Plains. A study was initiated in 2012 with six white prairie clover populations collected from the Canadian Prairies. Plant growth characteristics, forage biomass, seed yield, and forage nutritive values were evaluated using a randomized complete block design in a field near Swift Current, SK. Three populations from Argyle, Carlowrie, and Big Grass Marsh (NCP588) in Manitoba displayed erect-type growth while those from Douglas Provincial Park and Stewart Valley in Saskatchewan and Writing on Stone Provincial Park in Alberta exhibited prostrate growth. The populations did not differ for mean biomass yield (79–104 g plant−1, p = 0.54) and mean seed yield (6.6–9.1 g plant−1, p = 0.69); however, they differed for bloom stage nutritional parameters such as acid detergent fibre (25%–30%, p = 0.04), neutral detergent fibre (34%–41%, p < 0.01), crude proteins (15%–18%, p < 0.01), phosphorus (0.24%–0.29%, p = 0.02), and iron content (144–360 ppm, p = 0.01). To our knowledge, this is the first report of comparative phenotypic, nutritional, and propagation study of native white prairie clover populations of Canada. The constraints and opportunities for successful domestication of white prairie clover as a forage crop are discussed.
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Guan, Qingdong, Tanner Shpiruk, Peyman Ezzati, Oleg Krokhin, Scott Gilpin, James Doerksen, Victor Spicer, Swaroop Bhagwat, John Wilkins, and Donna A. Wall. "Proteomic Analysis of Reprograming of Mesenchymal Stem/Stromal Cells (MSC) Following Interferon Gamma Identifies Pathways That Are Upregulated in Suppression." Blood 126, no. 23 (December 3, 2015): 384. http://dx.doi.org/10.1182/blood.v126.23.384.384.
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Abstract Assessing potency of mesenchymal stem/stromal cells (MSC) used for immunologic applications such as the treatment of GVHD or other inflammatory disorders has been a challenge. Expression of PD-L1 or production of indoleamine-pyrrole 2,3-dioxygenase (IDO-1) has been proposed as potential potency markers. To screen for other pathways involved with suppression we undertook proteomic analysis of IFN-γ stimulated MSC. MSC isolated and expanded from normal healthy donors to 70-80% confluence were treated overnight with human rIFN-γ (30ng/ml). MSC were harvested using TrypLE Select and then immunologic and proteomic studies were performed. IFN-γ exposure increased a) MSC expression of IDO-1 and PD-L1, b) MSC suppression of 3rd party T lymphocyte proliferation, c) MSC inhibition of development of IFN-γ producing T lymphocytes, and d) MSC promotion of Treg expansion. Cellular proteomic changes that occur with IFN-γ exposures were studied in paired samples of control and IFN-γ treated MSC. Samples were prepared using a modified Filter Aided Sample Prep (FASP) and digests were separated using 2D liquid chromatography and analysed by tandem mass spectrometry. Data was processed with the Global Proteome Machine and only proteins with at least two confident peptides were reported. A total of 7621 proteins were identified of which 5575 were seen in all samples and 232 proteins were significantly upregulated in the IFN-γ treated cells relative to their controls. The proteomic analysis identified constitutive proteins seen in MSC. The upregulated proteins were significantly enriched (p<10-17) for GO processes such as "response to IFN-γ" and "cytokine mediated signaling pathway". Known inhibitory mediators (such as IDO-1, PD-L1, PGE2, galectin-9) were upregulated. Interestingly adhesion molecules (ICAM-1, VCAM-1, and CCL9) were increased. Other proteins with increased expression include Bone Marrow Stromal 2 (BST2). Conclusion: Proteomic analysis of response of MSC to IFN-γ has identified a signature of proteins upregulated with the activation of immune suppressive functions of MSC. Once confirmed these findings will support the development of a potency test for immunosuppressive potential of given MSC preparations - something that is sorely needed in the clinical manufacturing of MSC products. Acknowledgments: Q.D. is holding a postdoctoral fellowship from MS Society of Canada. This research was supported by The Bihlers' Professorship in Stem Cell Research to D.W. Disclosures No relevant conflicts of interest to declare.
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Way, M., M. Sanders, C. Garcia, J. Sakai, and P. Matsudaira. "Sequence and domain organization of scruin, an actin-cross-linking protein in the acrosomal process of Limulus sperm." Journal of Cell Biology 128, no. 1 (January 1, 1995): 51–60. http://dx.doi.org/10.1083/jcb.128.1.51.
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The acrosomal process of Limulus sperm is an 80-microns long finger of membrane supported by a crystalline bundle of actin filaments. The filaments in this bundle are crosslinked by a 102-kD protein, scruin present in a 1:1 molar ratio with actin. Recent image reconstruction of scruin decorated actin filaments at 13-A resolution shows that scruin is organized into two equally sized domains bound to separate actin subunits in the same filament. We have cloned and sequenced the gene for scruin from a Limulus testes cDNA library. The deduced amino acid sequence of scruin reflects the domain organization of scruin: it consists of a tandem pair of homologous domains joined by a linker region. The domain organization of scruin is confirmed by limited proteolysis of the purified acrosomal process. Three different proteases cleave the native protein in a 5-kD Protease-sensitive region in the middle of the molecule to generate an NH2-terminal 47-kD and a COOH-terminal 56-kD protease-resistant domains. Although the protein sequence of scruin has no homology to any known actin-binding protein, it has similarities to several proteins, including four open reading frames of unknown function in poxviruses, as well as kelch, a Drosophila protein localized to actin-rich ring canals. All proteins that show homologies to scruin are characterized by the presence of an approximately 50-amino acid residue motif that is repeated between two and seven times. Crystallographic studies reveal this motif represents a four beta-stranded fold that is characteristic of the "superbarrel" structural fold found in the sialidase family of proteins. These results suggest that the two domains of scruin seen in EM reconstructions are superbarrel folds, and they present the possibility that other members of this family may also bind actin.
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Jia, Bosen, Robert L. Conner, Waldo C. Penner, Chunfang Zheng, Sylvie Cloutier, Anfu Hou, Xuhua Xia, and Frank M. You. "Quantitative Trait Locus Mapping of Marsh Spot Disease Resistance in Cranberry Common Bean (Phaseolus vulgaris L.)." International Journal of Molecular Sciences 23, no. 14 (July 11, 2022): 7639. http://dx.doi.org/10.3390/ijms23147639.
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Common bean (Phaseolus vulgaris L.) is a food crop that is an important source of dietary proteins and carbohydrates. Marsh spot is a physiological disorder that diminishes seed quality in beans. Prior research suggested that this disease is likely caused by manganese (Mn) deficiency during seed development and that marsh spot resistance is controlled by at least four genes. In this study, genetic mapping was performed to identify quantitative trait loci (QTL) and the potential candidate genes associated with marsh spot resistance. All 138 recombinant inbred lines (RILs) from a bi-parental population were evaluated for marsh spot resistance during five years from 2015 to 2019 in sandy and heavy clay soils in Morden, Manitoba, Canada. The RILs were sequenced using a genotyping by sequencing approach. A total of 52,676 single nucleotide polymorphisms (SNPs) were identified and filtered to generate a high-quality set of 2066 SNPs for QTL mapping. A genetic map based on 1273 SNP markers distributed on 11 chromosomes and covering 1599 cm was constructed. A total of 12 stable and 4 environment-specific QTL were identified using additive effect models, and an additional two epistatic QTL interacting with two of the 16 QTL were identified using an epistasis model. Genome-wide scans of the candidate genes identified 13 metal transport-related candidate genes co-locating within six QTL regions. In particular, two QTL (QTL.3.1 and QTL.3.2) with the highest R2 values (21.8% and 24.5%, respectively) harbored several metal transport genes Phvul.003G086300, Phvul.003G092500, Phvul.003G104900, Phvul.003G099700, and Phvul.003G108900 in a large genomic region of 16.8–27.5 Mb on chromosome 3. These results advance the current understanding of the genetic mechanisms of marsh spot resistance in cranberry common bean and provide new genomic resources for use in genomics-assisted breeding and for candidate gene isolation and functional characterization.
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Bohrmann, J., and K. Biber. "Cytoskeleton-dependent transport of cytoplasmic particles in previtellogenic to mid-vitellogenic ovarian follicles of Drosophila: time-lapse analysis using video-enhanced contrast microscopy." Journal of Cell Science 107, no. 4 (April 1, 1994): 849–58. http://dx.doi.org/10.1242/jcs.107.4.849.
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In Drosophila oogenesis, several morphogenetic determinants and other developmental factors synthesized in the nurse cells have been shown to accumulate in the oocyte during pre- to mid-vitellogenic stages. However, the mechanisms of the involved intercellular transport processes that seem to be rather selective have not been revealed so far. We have investigated in vitro, by means of video-enhanced contrast time-lapse microscopy, the transport of cytoplasmic particles from the nurse cells through ring canals into the oocyte during oogenesis stages 6–10A. At stage 7, we first observed single particles moving into the previtellogenic oocyte. The particle transfer was strictly unidirectional and seemed to be selective, since only some individual particles moved whereas other particles lying in the vicinity of the ring canals were not transported. The observed transport processes were inhibitable with 2,4-dinitrophenol, cytochalasin B or N-ethylmaleimide, but not with microtubule inhibitors. At the beginning of vitellogenesis (stage 8), the selective translocation of particles through the ring canals became faster (up to 130 nm/second) and more frequent (about 1 particle/minute), whereas during mid-vitellogenesis (stages 9–10A) the velocity and the frequency of particle transport decreased again. Following their more or less rectilinear passage through the ring canals, the particles joined a circular stream of cytoplasmic particles in the oocyte. This ooplasmic particle streaming started at stage 6/7 with velocities of about 80 nm/second and some reversals of direction at the beginning. The particle stream in the oocyte was sensitive to colchicine and vinblastine, but not to cytochalasin B, and we presume that it reflects the rearrangement of ooplasmic microtubules described recently by other authors. We propose that during stages 7–10A, a selective transport of particles into the oocyte occurs through the ring canal along a polarized scaffold of cytoskeletal elements in which microfilaments are involved. This transport might be driven by a myosin-like motor molecule. Either attached to, or organized into, such larger particles or organelles, specific mRNAs and proteins might become selectively transported into the oocyte.
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Chorna, I. V., G. B. Dronik, T. O. Lukashiv, and V. D. Yuzkova. "Oxidatively modified proteins in kidneys of rats fed with glyphosate-resistant genetically modified soybean and the herbicide Roundup." Regulatory Mechanisms in Biosystems 10, no. 3 (August 22, 2019): 319–25. http://dx.doi.org/10.15421/021949.
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Genetic technologies have become a tool for achieving the desired properties of plant crops instead of traditional breeding in recent decades. They consist in artificial editing of a plant genome (genetic modification) by inserting the genes encoding desired features from the DNA of one organism in another, often unrelated, species. One of the most popular crops is soybean containing up to 38–42% of proteins in its seeds, and its most common type is GTS 40-3-2 (Monsanto Canada Inc.) line of transgenic soybean. The genetically modified soybean "Roundup Ready" is resistant to the action of herbicide "Roundup" (it continues to grow when it is cultivated with this herbicide). Therefore, the study of individual and combined effects of both factors on the free radical oxidation processes in biomolecules is very relevant. Experimental research was performed on 4-month Wistar rats to study the long-term effects of feeding with genetically modified soybean and herbicide "Roundup", both separately and together, on the rat kidneys. The results of the study showed that after 12 months of feeding with genetically modified soybean treated with herbicide "Roundup" (IV group) and receiving the herbicide with drinkable water (V group), there was an increase in the level of carbonyl derivatives in the rat kidney homogenates in the first (F0) and in subsequent generations (F1, F2) of rats. The research results showed that the highest level of carbonyl derivatives was noted in the kidneys of the third generation of rats. Along with the increase in oxidatively modified proteins in the rat kidney homogenates, there was a decrease in the content of sulfhydryl groups and proteolytic enzymes in the IV and V groups, the lowest level was observed in the third generation. The use of the same transgenic soybean variety not treated with any herbicide did not lead to an increase in the level of carbonyl derivatives and a decrease in the content of sulfhydryl groups compared to control group rats. Thus, the obtained experimental data indicate that both feeding with the genetically modified soybean treated with the herbicide and receiving the herbicide "Roundup" with drinkable water lead to the initiation of free radical processes in the kidneys of rats of all three generations and imbalance of the oxidant–antioxidant system, most notably in the third generation of rats. Such research results indicate the negative effects of the investigated factors and indicate that the herbicide "Roundup" may be accumulated in the seeds of transgenic soybean and also it may increase the oxidative modification of proteins in the rat kidneys. Hence, it is necessary to carry out a detailed study of the effects of these factors on histochemical changes in the kidney and liver structure and an investigation of antioxidant enzyme activity in these organs.
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Downs, Shauna M., and Noreen D. Willows. "Should Canadians eat according to the traditional Mediterranean diet pyramid or Canada’s food guide?" Applied Physiology, Nutrition, and Metabolism 33, no. 3 (June 2008): 527–35. http://dx.doi.org/10.1139/h08-030.
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Eating well with Canada’s food guide (CFG) was developed by Health Canada as an education tool to encourage the Canadian public to have eating habits that meet nutrient needs, promote health, and reduce the risk of nutrition-related chronic disease. It was developed in the Canadian context and reflects the food supply available to Canadians, as well as food choices made by Canadians. There are other dietary patterns that are consistent with health such as the traditional Mediterranean diet (TMD), which has gained popularity in Canada. The potentially different food choices that Canadians could make if they were to follow one guide over the other might significantly influence population health. Although the two guides differ in their recommendations for red wine, fats, and meat and meat alternatives, they both promote a diet rich in grains, fruits, and vegetables. The CFG may have some advantages over the TMD for Canadians, such as focusing on vitamin D and recommending limited alcoholic beverage intake. Some shortcomings of the CFG compared with the TMD are the grouping of animal proteins with nuts, seeds, and legumes into a single category, and not recommending limits for red meat consumption. If Canadians following the CFG were to choose whole grains and vegetarian options from the meat and alternatives category more often, the CFG may be preferable to TMD for Canadians. The TMD is an alternative to the CFG for Canadians if sources of vitamin D are included in the diet and wine consumption is limited or is imbibed in moderation.
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Shih, Andrew, Ian H. Chin-Yee, Ben Hedley, Mike Keeney, Richard A. Wells, D. Robert Sutherland, and Cyrus C. Hsia. "Screening Patients with Myelodysplastic Syndrome and Aplastic Anemia for Paroxysmal Nocturnal Hemoglobinuria Clones: A Retrospective Study,." Blood 118, no. 21 (November 18, 2011): 3426. http://dx.doi.org/10.1182/blood.v118.21.3426.3426.
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Abstract Abstract 3426 Introduction: Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare disorder due to a somatic mutation in the hematopoietic stem cell. The introduction of highly sensitive flow cytometric and aerolysin testing have shown the presence of PNH clones in patients with a variety of other hematological disorders such as aplastic anemia (AA) and myelodysplasic syndrome (MDS). It is hypothesized that patients with these disorders and PNH clones may share an immunologic basis for marrow failure with relative protection of the PNH clone, due to their lack of cell surface expression of immune accessory proteins. This is supported by the literature showing responsiveness in AA and MDS to immunosuppressive treatments. Preliminary results from a recent multicenter trial, EXPLORE, notes that PNH clones can be seen in 70% of AA and 55% of MDS patients, and therefore there may be utility in the general screening of all patients with bone marrow failure (BMF) syndromes. Furthermore, it has been suggested that the presence of PNH cells in MDS is a predictive biomarker that is clinically important for response to immunosuppressive therapy. Methods: Our retrospective cohort study in a tertiary care center used a high sensitivity RBC and FLAER assay to detect PNH clones as small as 0.01%. Of all patients screened with this method, those with bone marrow biopsy and aspirate proven MDS, AA, or other BMF syndromes (defined as unexplained cytopenias) were analysed. Results from PNH assays were compared to other clinical and laboratory parameters such as LDH. Results: Overall, 102 patients were initially screened over a 12 month period at our center. 30 patients were excluded as they did not have biopsy or aspirate proven MDS, AA, or other BMF syndromes. Of the remaining 72 patients, four patients were found to have PNH clones, where 2/51 had MDS (both RCMD, IPSS 0) [3.92%] and 2/4 had AA [50%]. The PNH clone sizes of these four patients were 0.01%, 0.01%, 0.02%, and 1.7%. None of the MDS patients with known recurrent karyotypic abnormalities had PNH clones present. Only one of the four patients had a markedly increased serum LDH level. Conclusions: Our retrospective study indicates much lower incidence of PNH clones in MDS patients or any patients with BMF syndromes when compared to the preliminary data from the EXPLORE trial. There is also significant disagreement in other smaller cohorts in regards to the incidence of PNH in AA and MDS. Screening for PNH clones in patients with bone marrow failure needs further study before adoption of widespread use. Disclosures: Keeney: Alexion Pharmaceuticals Canada Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees. Wells:Alexion Pharmaceuticals Canada Inc: Honoraria. Sutherland:Alexion Pharmaceuticals Canada Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees.
Book chapters on the topic "Canary seed proteins"
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Holmes, Amy Austin. "Introduction." In Coups and Revolutions, 3–12. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190071455.003.0001.
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In 2011 Egypt witnessed more protests than any other country in the world, kicking off a revolutionary process that would unfold in three waves of revolution, followed by two waves of counterrevolution. This chapter briefly contrasts the period of Gamal Abdel Nasser to the recent wave of upheaval. Nasser and the Free Officers implemented wide-ranging reforms by overthrowing the monarchy, declaring a republic, implementing land reform, expropriating the Suez Canal, expelling British troops from Egypt, and joining the nonaligned movement in efforts to move away from the colonial past. In so doing they turned a coup into a “revolution from above.” By contrast, President Abdel Fattah El-Sisi has not implemented any major reforms. His actions have led to the reconstitution of the old Mubarak regime, but with even greater authoritarianism aimed to crush any entity that is seen as independent of the regime. Instead of setting Egypt on a path of greater economic independence, Egypt’s reliance on foreign donors has grown, with increased financial flows from the Gulf. As a crude form of “payback” for this financial support, Egypt handed over the Tiran and Sanafir islands to Saudi Arabia.
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Atkinson, Martin E. "Development of the central nervous system." In Anatomy for Dental Students. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199234462.003.0027.
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The early development of the nervous system, the process of neurulation, has already been outlined in Chapter 8 and illustrated in Figure 8.4. To briefly recap, an area of dorsal ectoderm is induced by the underlying notochord to form the neural plate during the third week of development. The lateral edges of the neural plate rise to form the neural folds which eventually fold over and unite in the midline by the end of the fourth week to produce the neural tube. A distinct cell population on the crest of the neural folds, the neural crest, migrates from the forming neural tube to form various structures, including components of the peripheral nervous system. The closed neural tube consists of a large diameter anterior portion that will become the brain and a longer cylindrical posterior section, the future spinal cord. Initially, the neural plate is a single cell layer, but concentric layers of cells can be recognized by the time the neural tube has closed. An inner layer of ependymal cells surrounds the central spinal canal. Neuroblasts, the precursors of neurons, make up the bulk of the neural tube called the mantle layer; this will become the grey matter of the spinal cord. Neuroblasts do not extend processes until they have completed their differentiation. When the cells in a particular location are fully differentiated, the neuronal processes emerging from the neuroblasts form an outer marginal layer which ultimately becomes the white matter of the spinal cord. Figure 19.1B shows that the neural tube changes shape due to proliferation of cells in the mantle layer. This figure also indicates two midline structures in the roof and floor of the tube, known as the roof plate and floor plate. They are important in the determination of the types of neurons that develop from the mantle layer. The floor plate is induced by the expression of a protein product of a gene called sonic hedgehog (SHH) produced by the underlying notochord; the floor plate then expresses the same gene itself. Neuroblasts nearest to the floor plate receive a high dose of SHH protein and respond by differentiating into motor neurons; as seen in Figure 19.1B, these cells group together to form bilateral ventrolateral basal plates.
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Francis, Brian A. "Complications Specifically Related to Trabectome® Surgery (Trabeculotomy Internal Approach)." In Complications of Glaucoma Surgery. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780195382365.003.0074.
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Current surgical therapy for open-angle glaucoma can be divided into procedures directed at decreasing aqueous inflow (such as cyclophotocoagulation) or increasing aqueous outflow. The latter group can be further subdivided into external filtering surgery (such as trabeculectomy and aqueous tube shunt implantation) and internal filtering surgery designed to enhance existing aqueous outflow pathways. Internal approaches provide an alternative to standard external filtering surgery and possibly reduce the complications, including hypotony, hypotony maculopathy, bleb leaks, blebitis, choroidal effusion and hemorrhage, bleb-related endophthalmitis, peripheral anterior synechiae (PAS) formation, posterior synechiae, cataract formation, diplopia, tube obstruction, conjunctival erosion, tube migration, corneal decompensation, and plate encapsulation. Anterior chamber angle surgery techniques include procedures performed by an internal approach (e.g., goniotomy, Trabectome® [NeoMedix Corporation, Tustin, California], trabecular stent [iStent®; Glaukos® Corp., Laguna Hills, California], excimer laser trabeculotomy) or by an external approach (e.g., canaloplasty [see Chapter 51] and viscocanalostomy). Trabeculotomy by internal approach with the Trabectome® is designed to create a direct pathway from the anterior chamber to Schlemm’s canal (SC) and the aqueous collector channels by using electrocautery to selectively ablate a portion of trabecular meshwork (TM) tissue and the inner wall of SC in order to increase aqueous outflow. The Trabectome® surgical device received FDA approval for clinical use in 2004. The system consists of 3 major components: a mobile stand with a gravity-fed bottle of balanced salt solution; a handpiece console with automated irrigation, aspiration, and microbipolar electrocautery; and a foot pedal to control these functions. The intraocular disposable handpiece (see Figure 50.1) tip contains a 19.5-gauge infusion sleeve and a 25-gauge irrigation and aspiration (I/A) port with a coupling for the ablation unit at the tip. The instrument incorporates a specially designed insulated triangular footplate that is bent at 90° at the end and is pointed in order to allow proper insertion through the TM into SC. The insulation on the footplate is made of a multilayered polymer coating that allows the instrument to glide along within the canal and protects the outer wall of SC from thermal and electrical injury.
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Carabenciov, Ivan D., and Michael W. Ruff. "Progressive Bilateral Arm Pain, Gait Disturbance, Constipation, and Urinary Retention." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin, 231–32. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0075.
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A 48-year-old woman sought care for progressive right arm and hand pain with radial nerve–distribution sensory loss. She had a past history of multiple prior athletics-associated, musculoskeletal, upper cervical spine injuries. Her symptoms were initially attributed to a right C6 radiculopathy. Over the next several months, the sensory loss spread to involve the entire right hand and subsequently the entire left hand. She had development of diffuse right hand weakness and a sense of imbalance that was particularly prominent while in the dark. Finally, she experienced progressive constipation and urinary retention. Magnetic resonance imaging of the cervical spine showed an expanded cervical spinal cord from C3 through C7-T1 with diffuse T2-hyperintense changes and heterogeneous gadolinium enhancement most prominent at C5-6. In combination with a congenitally small central canal, severe central canal narrowing was seen at C5-6 and moderate narrowing at C4-5. Magnetic resonance imaging of the brain and thoracic spine were normal, and magnetic resonance imaging of the lumbar spine indicated only mild lumbar spondylosis. On suspicion of a spinal cord neoplasm with a secondary compressive myelopathy, C3 through C7 laminectomy and posterior instrumented fusion from C2 through T1 was performed, with a biopsy obtained at the C5-6 level. Postoperatively, her gait and right upper extremity pain improved. The biopsy showed atypical glial cells. Neurofilament staining demonstrated an infiltrative pattern. Atypical cells were positive for glial fibrillary acidic protein, oligodendrocyte transcription factor 2, and a Lys27Met sequence variation of histone H3, with overexpression of p53 on immunohistochemical staining. There was loss of H3 K27-trimethylation on the infiltrating cells, corresponding to the presence of Lys27Met sequence variation of histone H3. These findings were diagnostic for diffuse midline glioma with Lys27Met sequence variation of histone H3 (World Health Organization grade IV). A total of 5,400 cGy of photon radiation was delivered in 30 fractions over 42 days. She was subsequently treated with an oral histone deacetylase inhibitor, panobinostat, for 12 months. During this time, she had clinical response to treatment and reported improvement in balance and numbness. Follow-up magnetic resonance imaging at 3 months showed a slight decrease in the size of the mass, and this response was sustained 1 year post radiotherapy. Diffuse midline gliomas that contain Lys27Met sequence variation of histone H3are incurable, often inoperable, midline brain tumors that are most commonly seen in the pediatric population. These tumors can also occur in adult patients and are considered high grade, even in the absence of features such as necrosis or microvascular proliferation.
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Zalewski, Nicholas L. "A Septuagenarian With Progressive Lower Extremity Weakness and Pain." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin, 235–37. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0077.
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A 75-year-old man was referred for evaluation of treatment-resistant transverse myelitis. His medical history included hypertension, coronary artery disease, benign prostatic hyperplasia, and chronic kidney disease. Eight years earlier, the patient noted development of radiating pain down the left lower extremity during long drives, lower extremity weakness and pain, on the left greater than right. He received epidural lumbar corticosteroid injections. Nine months before the current evaluation, his symptoms became refractory, and he underwent surgical decompression with laminectomy at L3-L5. This provided substantial relief for the lower extremity pain. Review of outside magnetic resonance imaging indicated multilevel lumbar stenosis before his surgery and possible, faint, T2-hyperintense cord signal extending into the conus. At the time his symptoms worsened, magnetic resonance imaging of the thoracic spine showed longitudinally extensive T2 hyperintensity extending from the thoracic cord into the conus without contrast enhancement. Evaluation in our department included cerebrospinal fluid analysis, which showed an increased protein concentration of 92 mg/dL, 1 total nucleated cell/µL, normal immunoglobulin G index, and no supernumerary oligoclonal bands. Magnetic resonance angiography of the spinal canal showed mild prominence of vascularity at T10-T12 but no clear spinal dural arteriovenous fistula. However, given the strong suspicion for spinal dural arteriovenous fistula in an older man with progressive myelopathy worsening with corticosteroids, longitudinally extensive lesion extending into the conus, and no evidence of inflammation, spinal digital subtraction angiography was performed. The spinal digital subtraction angiography confirmed the diagnosis of left spinal dural arteriovenous fistula at T11. A T11-12 laminectomy and ligation of the spinal dural arteriovenous fistula was successfully performed without complication. The patient followed up with his local providers for rehabilitation. Spinal dural arteriovenous fistula is the most common spinal arteriovenous malformation, arising from an acquired abnormal connection between a radicular artery and radiculomedullary vein. Progressive congestion and cord edema lead to neurologic deficits over time. Cases are commonly seen in older men with a history of back surgery or trauma. A delay in diagnosis of 1 to 3 years is common.
Conference papers on the topic "Canary seed proteins"
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L'Hocine, Lamia, Allaoua Achouri, Emily Mason, and Mélanie Pitre. "Allergenicity risk assessment of glabrous canaryseed as novel food protein source." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/hyzq5376.
Full textAbstract:
Glabrous canaryseed, a novel cereal grain, is emerging as a valuable source of plant proteins due to its high content in protein (22%). This true cereal was approved for human consumption in Canada and the United States, and as part of the regulatory safety assessment, its allergenic potential was evaluated. Canaryseed was found to be gluten-free and thus, suitable for individuals with celiac disease, however, possible allergic cross-reactivity between canaryseed and wheat was also revealed. Based on these findings, a cautionary labelling alluding to the potential of allergic reaction is requested on canaryseed food products, and further research to clarify the relationship between canary seed proteins and known wheat allergens was recommended. Therefore, the purpose of this study was to further assess the immunological cross-reactivity risks of canary seed to phylogenetically related grains, including wheat and oat, using wheat-allergic sera IgE based 1D and 2D- immunoblots and ELISA, followed by proteomic/bioinformatics identification of IgE-binding proteins. The results demonstrated extensive serological cross-reactivity between wheat, oat and canaryseed proteins, where the less abundant protein fractions showed the strongest IgE-binding. The in-gel tryptic digestion and LC-MS/MS identification of the IgE-binding canaryseed proteins showed high homology to proteins from wheat, barley, oat and Brachypodium distachyon (also known as stiff brome), which all belong to the Pooideae botanical subfamily. A majority of the IgE-binding proteins were mostly minor metabolic enzymes or uncharacterized proteins. Low sequence homology was observed for the 11-12S globulin storage proteins. Positive serological testing cannot ascertain allergic reaction to canaryseed, it does not rule out, however, the risks for wheat, oat or barley sensitized atopic population. Clinical oral food challenge remains the ultimate tool to conclude on the allergenicity of canaryseed. Until then, these data serve the reinforcement of the regulatory requirement to use allergen precautionary labeling for products containing canaryseed proteins.
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Hang, Jiayi, Da Shi, James House, and Jason Neufeld. "Prediction of protein and amino acid contents in whole and ground lentils using near-infrared reflectance spectroscopy." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/pqtj3002.
Full textAbstract:
Lentil (Lens culinaris Medik) is an important source of plant-based protein, and the protein and amino acid contents have a significant influence on its nutritional value and use. This study developed near-infrared reflectance spectroscopy (NIRS) calibration models to predict the protein and 18 amino acid contents of lentil seeds. The effects of sample status (whole and ground), type of spectrometer (DA 7250 and FT 9700), and amino acid/protein correlation on model performance were analyzed and evaluated. In total, 361 lentil samples grown in Saskatchewan, Canada, were selected as a calibration set. These samples were scanned by spectrometers and analyzed by reference wet chemistry methods to obtain spectral data and reference data, respectively. NIRS models developed by partial least squares (PLS) equation had a satisfactory performance for measuring protein and most amino acids (except for histidine, tyrosine, methionine, and cysteine) in lentils with high coefficients of determination for calibration (R2C = 0.652–0.927) and residual predictive deviation (RPD = 1.570 – 3.101). NIRS models from DA 7250 achieved similar accuracy for the determination of crude protein and amino acids in whole and ground lentils. DA 7250 models had a slightly better predictive ability with higher coefficients of determination for cross-validation (R2CV) and RPD values than FT 9700 models for all compositions except histidine. However, the predicted data of the two spectrometers did not differ significantly (p > 0.05) for every composition. For amino acids highly correlated to crude protein, NIRS generally predicted them with higher accuracy. Overall, NIRS combined with PLS regression yielded significant potential for rapid and simultaneous prediction of protein and most amino acid contents in lentils with satisfactory accuracy, and these models were usable for research purposes or sample screening.
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Thacher, Eric, Helen Bailey, Bryson Robertson, Scott Beatty, Jason Goldsworthy, Curran Crawford, and Bradley Buckham. "Development of Control Strategies for Interconnected Pneumatic Wave Energy Converters." In ASME 2017 36th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/omae2017-61537.
Full textAbstract:
In the field of wave energy converter control, high fidelity numerical models have become the predominant tool for the development of accurate and comprehensive control strategies. In this study, a numerical model of a novel wave energy converter, employing a pneumatic power take-off, is created to provide a low-cost method for the development of a power-maximizing control strategy. Device components and associated architectures are developed in the time domain solvers Proteus DS and MATLAB/Simulink. These two codes are dynamically coupled at run time to produce a complete six degree of freedom, time domain simulation of the converter. Utilizing this numerical framework, a genetic algorithm optimization procedure is implemented to optimally select eight independent parameters governing the PTO geometry. Optimality is measured in terms of estimated annual energy production at a specific deployment location off the West Coast of Canada. The optimization exercise is one layer of PTO force control — the parameters selected are seen to provide significant improvements in the annual power output, while also smoothing the WEC power output on both a sea-state by sea-state and wave-by-wave basis.
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Ewins, Peter J. "Protected Areas and Pipelines in Canada: Balancing Natural Values With Development at the Landscape Level — The Conservation First Principle." In 2002 4th International Pipeline Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/ipc2002-27276.
Full textAbstract:
“Sustainable Development” is now a widely accepted concept, yet there are surprisingly few concrete examples of it in practice. The pipeline industry operates at broad landscape and regional levels, and now has the opportunity to provide a strong lead in showcasing how society can benefit from major new energy pipelines while not significantly compromising natural and cultural values. To achieve this requires adoption of a fundamental proactive, ecosystem-based principle — the “Conservation First Principle”. In Canada this principle, first stated by Hummel [1], is that “there should be no new or expanded large-scale industrial development until a network of protected areas is reserved which adequately represents the natural region(s) affected by that development”. This approach is not new (e.g., the 1992 commitment by all levels of Canada’s governments to complete such protected areas networks), but it is more urgently needed now in an energy-rich frontier nation like Canada to truly safeguard our natural and cultural values while developing new energy corridors. It is a precautionary approach, akin to an insurance policy we would all be familiar with at a personal level. By identifying key natural habitats in each natural region (areas of similar bio-physical characteristics — there are 486 terrestrial natural regions in Canada), and using sophisticated GIS-based gap analysis, working with local communities, industry and governments, a network of protected areas can be identified and then reserved for legal protection. This network then adequately protects a representative sample of habitats, biodiversity and ecosystem processes in each natural region before or simultaneous with development proposals and approvals. The development of natural gas reserves in the Mackenzie Valley provides all stakeholders with a timely high-profile opportunity to showcase this balanced approach. The NWT’s Protected Areas Strategy provides the widely-supported community-led process to identify and then reserve key cultural and ecological areas in tandem with gas pipeline development. Investors, industry, governments, local communities and the general public all seek the greater certainty and security that such advance planning and balancing provides. The knowledge that certain key areas are off-limits to future development, and that other areas (the largest portion of each natural region) are assigned for sensitive industrial development, sets the stage for a more secure, stable future, in which all values are accommodated satisfactorily. In the push for greater energy security, the pipeline and oil and gas industry should now embrace the Conservation First Principle in energy developments across Canada’s lands and oceans, most immediately as it plans for a major gas pipeline in the Mackenzie Valley.