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Journal articles on the topic 'Cambogia'

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Author: Grafiati

Published: 10 March 2023

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1

Han, Joo-Hui, Min-Ho Park, and Chang-Seon Myung. "Garcinia cambogia Ameliorates Non-Alcoholic Fatty Liver Disease by Inhibiting Oxidative Stress-Mediated Steatosis and Apoptosis through NRF2-ARE Activation." Antioxidants 10, no. 8 (July 29, 2021): 1226. http://dx.doi.org/10.3390/antiox10081226.

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Excessive free fatty acids (FFAs) causes reactive oxygen species (ROS) generation and non-alcoholic fatty liver disease (NAFLD) development. Garcinia cambogia (G. cambogia) is used as an anti-obesity supplement, and its protective potential against NAFLD has been investigated. This study aims to present the therapeutic effects of G. cambogia on NAFLD and reveal underlying mechanisms. High-fat diet (HFD)-fed mice were administered G. cambogia for eight weeks, and steatosis, apoptosis, and biochemical parameters were examined in vivo. FFA-induced HepG2 cells were treated with G. cambogia, and lipid accumulation, apoptosis, ROS level, and signal alterations were examined. The results showed that G. cambogia inhibited HFD-induced steatosis and apoptosis and abrogated abnormalities in serum chemistry. G. cambogia increased in NRF2 nuclear expression and activated antioxidant responsive element (ARE), causing induction of antioxidant gene expression. NRF2 activation inhibited FFA-induced ROS production, which suppressed lipogenic transcription factors, C/EBPα and PPARγ. Moreover, the ability of G. cambogia to inhibit ROS production suppressed apoptosis by normalizing the Bcl-2/BAX ratio and PARP cleavage. Lastly, these therapeutic effects of G. cambogia were due to hydroxycitric acid (HCA). These findings provide new insight into the mechanism by which G. cambogia regulates NAFLD progression.

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2

Yu, Jun, Min Choi, Jong Park, Shaheed Rehman, Katsunori Nakamura, and Hye Yoo. "Inhibitory Effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity." Planta Medica 83, no. 11 (March 13, 2017): 895–900. http://dx.doi.org/10.1055/s-0043-104934.

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AbstractThis study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner. Furthermore, the inhibition was potentiated following preincubation with NADPH, indicating that G. cambogia extract is a time-dependent inhibitor of CYP2B6. Meanwhile, hydroxycitric acid, the major bioactive ingredient of G. cambogia extract, did not exhibit significant inhibition effects on cytochrome P450 enzyme activities. G. cambogia extract could modulate the pharmacokinetics of CYP2B6 substrate drugs and lead to interactions with those drugs. Therefore, caution may be required with respect to concomitant intake of dietary supplements containing G. cambogia extract with CYP2B6 substrates.

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3

Sudarshan, M., and P. Jyothibai. "Angiotensin Converting Enzyme and Trypsin Inhibition by Garcinia Cambogia Seeds Extract." International Journal of Research in Engineering, Science and Management 3, no. 12 (January 3, 2021): 186–90. http://dx.doi.org/10.47607/ijresm.2020.434.

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In this project work, Garcinia cambogia seeds extract was prepared and analysed for inhibitory studies. G. cambogia or the Malabar tamarind, commonly used as a food preservative, flavouring agent or food-bulking agent, and as a traditional remedy to treat constipation, piles, rheumatism, edema, irregular menstruation and intestinal parasites in many Asian countries. G. cambogia seeds solvents (Methanol, ethylacetate, petroleum ether and acetone) extract were prepared and pharmacological activities were analyzed such as antioxidant activity, ACE inhibitory and trypsin inhibitory activities. Among the extracts tested, methanolic extract of G. cambogia has shown potent antioxidant, angiotensin converting enzyme and trypsin inhibitory activities.

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4

Nguyen, David C., Tysen K. Timmer, Blair C. Davison, and Ian R. McGrane. "Possible Garcinia cambogia-Induced Mania With Psychosis: A Case Report." Journal of Pharmacy Practice 32, no. 1 (October 5, 2017): 99–102. http://dx.doi.org/10.1177/0897190017734728.

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Garcinia cambogia is a Southeast Asian fruit becoming increasingly popular as a weight management supplement. Hydroxycitric acid (HCA) is the primary active ingredient which demonstrates serotonergic- and muscarinic-enhancing properties via inhibition of selective serotonin reuptake and acetylcholinesterase. We report a young adult female with no history of bipolar disorder who developed mania and psychosis approximately 1 week following initiation of G cambogia and the Cleanse and Detox™ dietary supplement manufactured by Apex Vitality Health. She presented with a predominantly expansive mood, psychomotor agitation, disorganized and pressured speech, flight of ideas, grandiosity, delusions, and auditory hallucinations. Following discontinuation of G cambogia and the initiation of lithium and quetiapine, the patient experienced rapid and progressive mood stabilization and was discharged after 8 days. Seven previous case reports associating (hypo)mania and/or psychosis with G cambogia consumption have been published. The chronology of mania and/or psychosis onset may appear between 1 and 8 weeks following initiation of G cambogia. Psychiatric symptoms have resolved with G cambogia discontinuation in some instances and may not require chronic pharmacotherapy. Our report should encourage further research and case reports regarding this adverse event and the reconciliation of complete herbal supplement use at clinic visits and hospital admissions.

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5

Cho, Hyun-kyung, Yong Seop Han, and Jong Moon Park. "Ocular complications of Garcinia cambogia extract diet pills: Case report." European Journal of Ophthalmology 30, no. 6 (October 3, 2019): NP21—NP26. http://dx.doi.org/10.1177/1120672119872364.

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Background: Garcinia cambogia contains hydroxycitric acid. Hydroxycitric acid is a potent competitive inhibitor of adenosine triphosphate citrate lyase which is a key enzyme in the synthesis of fatty acids. Hydroxycitric acid also regulates the level of serotonin. In these regards, hydroxycitric acid has been reported to exhibit weight loss activity. Adverse reactions of G. cambogia from numerous clinical studies demonstrated relatively mild reactions. However, there are some complications of G. cambogia reported in the past: acute liver injury, acute hepatitis, and hepatic failure. However, ocular complications of G. cambogia have not been reported yet. Case presentation: A 35-year-old female visited our clinic with decreased vision in the left eye and ocular pain in both eyes for the last 6 days. She also complained of headache, dizziness, and nausea. She had taken G. cambogia extract more than the recommended dose. There was myopic shift with anterior chamber shallowing in both eyes, especially in the left eye. Moreover, swelling and retinal folds of peripapillary retinal nerve fiber layer and macula were observed in both eyes. These ocular complications of G. cambogia extract resolved after discontinuation of the extract and topical and oral steroid treatment. Herein, we report the first case of ocular complications of G. cambogia extract diet pill assessed with optical coherence tomography of optic disk and macula along with dual Scheimpflug analyzer. Conclusion: It is necessary that physicians dealing with obesity advice patients about possible visual disturbance of this extract when taken in overdose so that they can see an ophthalmologist immediately.

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6

Mas Ordeig, Antoni, and Noel Bordón García. "Hepatotoxicidad por Garcinia cambogia." Gastroenterología y Hepatología 43, no. 3 (March 2020): 134–35. http://dx.doi.org/10.1016/j.gastrohep.2019.08.005.

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7

Lim, G. W., S. Jafarzadeh, and Norazatul Hanim M.R. "Kinetic study, optimization and comparison of sun drying and superheated steam drying of asam gelugor (Garcinia cambogia)." Food Research 4, no. 2 (October 17, 2019): 396–406. http://dx.doi.org/10.26656/fr.2017.4(2).288.

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The purposes of present study are to compare the kinetic drying of the G. cambogia through sun drying and superheated steam drying (SSD) method and optimizing the quality of SSD of it through response surface methodology. G. cambogia fruit rinds were dried at temperature of 150°C, 200°C and 250°C. The drying curves were fitted into the mathematical model of Page, Lewis and Henderson-Pabis models. Page model was found to be the best in describing the drying behavior of G. cambogia. Drying rate constant (k) increased as temperature increased and SSD method had overall higher drying rates ranged from 5.929 x 10-5 to 5.861 x 10-4 min-1 than sun drying method which was 4.980 x 10-6 min-1 . Total acid number showed a trend of increased followed by decreased over drying time. superheated steam drying process of G. cambogia fruit rinds was optimized by using response surface methodology employing a central composite design. Drying time and temperature were the factors in optimization while moisture content (wet basis), acid number and lightness (*L) were the response parameters. Experimental results were fitted to a second-order polynomial model and the model fitness and optimal drying condition were determined by regression analysis and analysis of variance. The optimal conditions for superheated steam drying of G. cambogia fruit rinds were identified as 46.60 mins and 150°C with the composite desirability of 0.913. Application of superheated steam drying under controlled conditions resulted in faster drying process and better quality of dried G. cambogia than conventional sun drying technique.

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8

Raju PSN, Suhasini N, Narayana Reddy, and Vignesh D. "Investigation and examination of vitro anti-arthritis activity by means of Cambogia fruit denaturation albumin." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (December 25, 2020): 751–55. http://dx.doi.org/10.26452/ijrps.v11ispl4.4059.

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With assessing those anti-arthritis actions in-vitro in chloroform extricate about garcinia Cambogia apples and oranges against egg whites denaturation. In regulated test condition egg whites might have been incubated for with different fixation for chloroform extricate Furthermore subjected will determination from claiming absorbance will assess the rate of protein restraint to Anti-arthritis movement utilizing diclofenac sodium as those standard medications regardless. Dosage reliant expand in the rate restraint might have been found. Likewise, an after effect. Restraint for egg whites denaturation might have been watched for every last one of centralization of the chloroform extricate from claiming garcinia Cambogia tree grown foods. Starting with that current study, it could be a chance to be closed that garcinia Cambogia tree grown foods possessed checked in vitro Anti-arthritis movement impact against denaturation for egg whites. Those impact might have been because of xanthone available Similarly as a standout amongst the phyto concoction segments On from claiming garcinia Cambogia tree grown foods.

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9

Kokkaiah Irulandi, Sethupandian Geetha, Anantharaj Tamilselvan, and Palanichamy Mehalingam. "GC-MS analysis and phytochemical studies of methanolic fruits extract of Garcinia cambogia Hort. Ex Boerl and Ziziphus trinervia Roth." JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH 1, no. 3 (December 15, 2021): 90–95. http://dx.doi.org/10.46947/joaasr13201623.

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The investigation was carried out to determine the possible phytochemical components from the methanolic extracts of Garcinia cambogia (fruits) and Ziziphus trinervia (fruits). Among the phytochemical screening of these two plant extracts showed that the plant was rich in alkaloids, flavonoids, phenols, saponins and quinones. This study was extended by analyzing the potent bioactive compounds in the methanolic extract of Garcinia cambogia (fruits) and Ziziphus trinervia (fruits) using GC-MS. The analysis revealed that Garcinia cambogia fruits extracts 40 compounds were identified in the fruit methanol extract. Another one plant Ziziphus trinervia methanol fruit extract showed 3 compounds were identified. Medicinal potential of these compounds needs further research on microbial aspects to develop safe drug

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10

Haber, Stacy L., Omar Awwad, April Phillips, Andrew E. Park, and Tam Minh Pham. "Garcinia cambogia for weight loss." American Journal of Health-System Pharmacy 75, no. 2 (January 15, 2018): 17–22. http://dx.doi.org/10.2146/ajhp160915.

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11

Iinuma, Munekazu, Tetsuro Ito, Ryoko Miyake, Hideki Tosa, Toshiyuki Tanaka, and Veliah Chelladurai. "A xanthone from Garcinia cambogia." Phytochemistry 47, no. 6 (March 1998): 1169–70. http://dx.doi.org/10.1016/s0031-9422(98)80096-4.

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12

Burdock, George, Manashi Bagchi, and Debasis Bagchi. "Garcinia cambogia toxicity is misleading." Food and Chemical Toxicology 43, no. 11 (November 2005): 1683–84. http://dx.doi.org/10.1016/j.fct.2005.05.011.

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13

Badmaev, V. "Garcinia cambogia for Weight Loss." JAMA: The Journal of the American Medical Association 282, no. 3 (July 21, 1999): 233–35. http://dx.doi.org/10.1001/jama.282.3.233.

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14

Mas Ordeig, Antoni, and Noel Bordón García. "Hepatotoxicity caused by Garcinia cambogia." Gastroenterología y Hepatología (English Edition) 43, no. 3 (March 2020): 134–35. http://dx.doi.org/10.1016/j.gastre.2019.08.010.

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15

Ariyanto, Eko Fuji, Nurul Ovifa Multom, Afiat Berbudi, Enny Rohmawaty, and Budi Sujatmiko. "Efficacy and Mechanism of Action of Aloe Vera, Cinnamomum Zeylanicum, Curcuma Longa, Garcinia Cambogia, and Garcinia Mangostana Extracts in Lowering Body Weight in Obesity: A Literature Review." Biomedical and Pharmacology Journal 14, no. 4 (December 30, 2021): 1791–97. http://dx.doi.org/10.13005/bpj/2278.

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The habits of today's society, which are influenced by economic growth and globalization have brought new lifestyles, especially those related to diet, resulting in minimal physical activity accompanied by a high calorie intake. This energy imbalance can lead to the metabolic syndrome, including obesity, which is still a burden on the world today. Some plants in Indonesia are believed to help lose weight, such as Aloe vera, Cinnamomum zeylanicum, Curcuma longa, Garcinia cambogia, and Garcinia mangostana. This literature review was conducted to determine the effects of Aloe vera, Cinnamomum zeylanicum, Curcuma longa, Garcinia cambogia, and Garcinia mangostana on weight loss and preventing obesity. The review of twelve relevant articles concluded that Aloe vera, Cinnamomum zeylanicum, Curcuma longa, Garcinia cambogia, and Garcinia mangostana have the potential to prevent and treat obesity but further research is required.

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16

Zothantluanga, James H., Hannah S. Lalnunpuii, Hans Raj Bhat, and Anshul Shakya. "Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach." Science Vision 19, no. 4 (December 31, 2020): 120–33. http://dx.doi.org/10.33493/scivis.19.04.02.

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The modern popular ideology is that plant-based products do not have adverse effects. Hence, people are fond of using herbal products of their choice to treat their own ailments or anyone else. As majority of the population are not aware of herbal toxicity concept, the use of formulated single or combined medicinal and/or nutritional plant extracts or isolated compounds to treat chronic diseases are increasingly popular due to the widespread concerns regarding the adverse effects of pharmaceutical drugs. Awareness from the scientific community to bring society to its senses regarding the safety issue of a herbal product is rare. Garcinia gummi-gutta (more popularly known by the synonym Garcinia cambogia in commercial preparations), belonging to the family of Clusiaceae (alt. Guttiferae) is a popularly consumed weight-loss nutraceutical. This review aims to highlight the possible adverse effects of G. cambogia. For the said purpose, 147 articles were collected from PubMed, Web of Science and Google scholar. Literature review revealed a plethora of beneficial actions. Investigational outcomes and clinical evidences hint the possible adverse effects likely to be linked with the use of G. cambogia. However, the use of G. cambogia as an anti-obesity agent is advisable as long as the therapeutic value outweighs the adverse effect.

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17

Nam, Hyun-wook, Keun-Tae Kim, Minji Song, Hayom Kim, and Jung Bin Kim. "Garcinia Cambogia-Induced Refractory Status Epilepticus." Journal of the Korean Neurological Association 40, no. 2 (May 1, 2022): 141–43. http://dx.doi.org/10.17340/jkna.2022.2.5.

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Garcinia cambogia (G.cambogia) is a herbal dietary supplement for managing obesity. Several adverse effects of G.cambogia have been reported including serotonin syndrome and mania. We report a patient with refractory status epilepticus after taking G.cambogia. A 24-year-old woman was admitted with continuing seizures. Based on electroencephalography and neuroimaging findings, she was diagnosed as refractory status epilepticus attributed to G.cambogia-related encephalopathy. After cessation of the G.cambogia with administrating antiepileptic drugs, she fully recovered without seizure recurrence and neurological sequelae.

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18

Bheemaiah, Madappa Machamada, Bopaiah Ajikuttira Kushalappa, and Grace Prabhakar. "Phylogenetic Assessment of Garcinia Species Using RAPD Markers." Biosciences Biotechnology Research Asia 15, no. 4 (December 19, 2018): 949–55. http://dx.doi.org/10.13005/bbra/2706.

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The plants in the Garcinia species are economically important. Phylogenetic investigation is needed for these tree species to boost breeding and conservation programmes. Six Garcinia species were investigated for their phylogenetic relationship using Random Amplified Polymorphic DNA(RAPD) markers. A standardised procedure was developed for isolation of DNA from the leaf samples of G. cambogia, G. indica, G. xanthochymus, G. morella, G. mangostana and G. livingstonei. Phylogenetic investigation is needed for these tree species to boost breeding and conservation programmes. A standardised procedure was developed for isolation of DNA from the leaf samples of G. cambogia, G. indica, G. xanthochymus, G. morella, G. mangostana and G. livingstonei. The DNA samples were subjected to PCR using 8 random primers. 269 polymorphic bands were obtained and scored to develop the values for the genetic distance. The dendrogram was developed using the software dendroUPGMA and the Cophenetic correlation coefficient of 0.801 is obtained. G. cambogia and G. livingstonei are closely placed with a score of 24% followed by G. morella. It had a 30% index score to G. cambogia and G. livingstonei but is followed by just 31% score with G. indica. G.mangostana is connected at 33.5% dissimilarity to the above groups showing it is an introduced variety. G. xanthochymus is the last link with 37% score in the matrix. The data represented is the first of the type for the species. This will help in further DNA related work in these species. The genetic relatedness among these species is reported and this can be utilised in marker analysis for other Garcinia species.

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Kothadia, Jiten P., Monica Kaminski, Hrishikesh Samant, and Marco Olivera-Martinez. "Hepatotoxicity Associated with Use of the Weight Loss Supplement Garcinia cambogia: A Case Report and Review of the Literature." Case Reports in Hepatology 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/6483605.

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The use of herbal and dietary supplements for weight loss is becoming increasingly common as obesity is becoming major health problem in the United States. Despite the popularity of these natural supplements, there are no guidelines for their therapeutic doses and their safety is always a concern. Garcinia cambogia extract with its active ingredient “hydroxycitric acid” is a component of many weight loss regimens. It suppresses fatty acid biosynthesis and decreases appetite. However, its prolonged use in weight maintenance is unknown. Here we describe a case of acute hepatitis after the use of Garcinia cambogia for weight loss.

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20

Teixeira, Wêmilly Cristina Reis, and Renato André Zan. "Análise bibliométrica da produção científica da Garcinia cambogia / Bibliometric analysis of the scientific production of Garcinia cambogia." Brazilian Journal of Development 8, no. 5 (May 18, 2022): 38659–73. http://dx.doi.org/10.34117/bjdv8n5-386.

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21

Tomar, Manu, Raghavendra Prahlad Rao, Palaniyamma Dorairaj, Abhishek Koshta, Sowbhagya Suresh, Mohamed Rafiq, Rajesh Kumawat, Rangesh Paramesh, Babu U. V, and K. V. Venkatesh. "A clinical and computational study on anti-obesity effects of hydroxycitric acid." RSC Advances 9, no. 32 (2019): 18578–88. http://dx.doi.org/10.1039/c9ra01345h.

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22

Napagoda, Mayuri, Jana Gerstmeier, Hannah Butschek, Sudhara De Soyza, Simona Pace, Sybille Lorenz, Mallique Qader, et al. "The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka." Molecules 25, no. 8 (April 20, 2020): 1894. http://dx.doi.org/10.3390/molecules25081894.

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Traditional folk medicine in Sri Lanka is mostly based on plants and plant-derived products, however, many of these medicinal plant species are scientifically unexplored. Here, we evaluated the anti-inflammatory and antimicrobial potency of 28 different extracts prepared from seven popular medicinal plant species employed in Sri Lanka. The extracts were subjected to cell-based and cell-free assays of 5-lipoxygenase (5-LO), microsomal prostaglandin E2 synthase (mPGES)-1, and nitric oxide (NO) scavenging activity. Moreover, antibacterial and disinfectant activities were assessed. Characterization of secondary metabolites was achieved by gas chromatography coupled to mass spectrometric (GC-MS) analysis. n-Hexane- and dichloromethane-based extracts of Garcinia cambogia efficiently suppressed 5-LO activity in human neutrophils (IC50 = 0.92 and 1.39 µg/mL), and potently inhibited isolated human 5-LO (IC50 = 0.15 and 0.16 µg/mL) and mPGES-1 (IC50 = 0.29 and 0.49 µg/mL). Lipophilic extracts of Pothos scandens displayed potent inhibition of mPGES-1 only. A methanolic extract of Ophiorrhiza mungos caused significant NO scavenging activity. The lipophilic extracts of G. cambogia exhibited prominent antibacterial and disinfectant activities, and GC-MS analysis revealed the presence of fatty acids, sesquiterpenes and other types of secondary metabolites. Together, our results suggest the prospective utilization of G. cambogia as disinfective agent with potent anti-inflammatory properties.

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Melendez-Rosado, Jose, David Snipelisky, Guatam Matcha, and Fernando Stancampiano. "Acute Hepatitis Induced by Pure Garcinia cambogia." Journal of Clinical Gastroenterology 49, no. 5 (2015): 449–50. http://dx.doi.org/10.1097/mcg.0000000000000303.

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24

Cotovio, Gonçalo, and Albino J. Oliveira-Maia. "Hypomania induced by a Garcinia cambogia supplement." Australian & New Zealand Journal of Psychiatry 51, no. 6 (September 14, 2016): 641–42. http://dx.doi.org/10.1177/0004867416667827.

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Patel, Krishna, Mechu Narayanan, and Brent Tetri. "Dietary Supplement Garcinia Cambogia Causing Liver Injury." American Journal of Gastroenterology 113, Supplement (October 2018): S1329. http://dx.doi.org/10.14309/00000434-201810001-02376.

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Semwal, Ruchi Badoni, Deepak Kumar Semwal, Ilze Vermaak, and Alvaro Viljoen. "A comprehensive scientific overview of Garcinia cambogia." Fitoterapia 102 (April 2015): 134–48. http://dx.doi.org/10.1016/j.fitote.2015.02.012.

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Bezerra, Geliwania Andrade, Caio José Florêncio dos Anjos, Liandra de Souza Oliveira, Mariana Plácido Brandão, Daniela de Araújo Vilar, and Marina Suênia de Araújo Vilar. "Potencial toxicológico e caracterização físico-quimica e fitoquimica da garcínia cambogia." Research, Society and Development 9, no. 4 (March 20, 2020): e71942987. http://dx.doi.org/10.33448/rsd-v9i4.2987.

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A utilização de plantas com fins medicinais usadas para tratamento, cura e prevenção de doenças é considerada uma prática milenar da humanidade. Dentre os parâmetros atuais, destaca-se a obesidade como sendo um problema de saúde pública mundial nos países desenvolvidos e em desenvolvimento. O estudo se propõe a delinear o potencial toxicológico, assim como, avaliar a caracterização físico-química e fitoquímica da Garcínia cambogia, a fim de contribuir para utilização segura dessa planta. Foram realizadas análises físico-químicas, fitoquímicas e toxicológica, a fim de caracterizar a qualidade e segurança dos extratos obtidos da Garcínia cambogia. Observou-se que o teor de material estranho, pH, cinzas totais e cinzas insolúveis em ácido estavam de acordo com os limites estabelecidos. Os valores para umidade estavam acima do permitido. Na triagem fitoquímica apresentou resultados negativos para flavonóides e taninos, e resultado positivo para saponinas. Para o teste de toxicidade aguda in vivo o extrato foi categorizado como sendo “categoria 5” (2000 a 2500 mg/kg), e a toxicidade letal aguda – DL50% estimada em 2500 mg/kg, sendo considerado atóxica. Na avaliação da toxicidade sistêmica não foram observadas diferenças significativas entre os animais do grupo teste e os do grupo controle. Não foram observadas alterações macroscópicas dos órgãos após os 14 dias de experimento, demonstrando ausência de toxicidade aguda. Com os resultados obtidos foi possível contribuir para um conhecimento mais aprofundado da Garcínia cambogia, com informações mais detalhadas do seu potencial toxicológico.

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Patel, Rakesh, Jaimin Patelb, and Saloni Kakkar. "Formulation & Development of Anti-Obesity Liquid Formulation Containing Garcinia Cambogia Extract, L-Carnitine & Chromium Picolinate." Indo Global Journal of Pharmaceutical Sciences 03, no. 01 (2013): 40–51. http://dx.doi.org/10.35652/igjps.2013.06.

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The aim of the current investigation is to develop antiobesity liquid formulation of Garcinia cambogia extract, LCarnitine and Chromium Picolinate, which gives good microbial stability and pharmacological activity. The formulation was prepared by using coconut water as base and flavour in different combinations. The prepared formulation was evaluated for general description, microbiological and drug content. The formulation showed acceptable physical, microbiological properties and complied with drug content limits. The results of assay of Garcinia cambogia (HCA content) was 108.23% and 108.16%, before and after stability study, by HPLC. L-Carnitine content in formulation was 106.15% and 105.58%, before and after stability study, by HPLC. Chromium picolinate content was 99.2% and 97.8%, before and after stability study, by AAS. From the results it was concluded that the formulation was relative stable. © 2011 IGJPS. All rights reserved.

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Corey, Rebecca, K. Tuesday Werner, Andrew Singer, Adyr Moss, Maxwell Smith, Jessica Noelting, and Jorge Rakela. "Acute liver failure associated with Garcinia cambogia use." Annals of Hepatology 15, no. 1 (January 2016): 123–26. http://dx.doi.org/10.5604/16652681.1184287.

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30

Yousaf, Muhammad Nadeem, Fizah S. Chaudhary, Sayed Mohammad Hodanazari, and Charmian D. Sittambalam. "Hepatotoxicity associated with Garcinia cambogia: A case report." World Journal of Hepatology 11, no. 11 (November 27, 2019): 735–42. http://dx.doi.org/10.4254/wjh.v11.i11.735.

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Paes, Sany Do Nascimento Dias, and Kamila Oliveira Do Nascimento. "Eficácia do uso da Garcinia cambogia no emagrecimento." Nutrição Brasil 18, no. 3 (February 13, 2020): 165. http://dx.doi.org/10.33233/nb.v18i3.2281.

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Park, Angela, Janyll Castineira, Marissa Bournique, Heather Babcock, Rebecca T. Miller, and Miriam Thomas. "2442 Garcinia Cambogia, Weight Loss at What Price?" American Journal of Gastroenterology 114, no. 1 (October 2019): S1351—S1352. http://dx.doi.org/10.14309/01.ajg.0000599300.59474.36.

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Biggs, Jessica M., Jill A. Morgan, Allison B. Lardieri, Omayma A. Kishk, and Wendy Klein-Schwartz. "Abuse and Misuse of Selected Dietary Supplements Among Adolescents: a Look at Poison Center Data." Journal of Pediatric Pharmacology and Therapeutics 22, no. 6 (December 1, 2017): 385–93. http://dx.doi.org/10.5863/1551-6776-22.6.385.

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OBJECTIVE The use of dietary supplements has increased and is associated with adverse effects. Indications for use include recreation, body image concerns, mood enhancement, or control of medical conditions. The risk of adverse effects may be enhanced if agents are used improperly. The objective of this study was to determine the frequency of abuse and misuse of 4 dietary substances among adolescents reported nationally to poison centers. Secondary outcomes included an assessment of medical outcomes, clinical effects, location of treatments provided, and treatments administered. METHODS This descriptive retrospective review assessed data concerning the use of garcinia (Garcinia cambogia), guarana (Paullinia cupana), salvia (Salvia divinorum), and St John's wort (Hypericum perforatum) among adolescents reported nationally to poison centers from 2003 to 2014. Adolescents with a singlesubstance exposure to one of the substances of interest coded as intentional abuse or misuse were included. Poison center calls for drug information or those with unrelated clinical effects were excluded. Data were collected from the National Poison Data System. RESULTS There were 84 cases: 7 cases of Garcinia cambogia, 28 Paullinia cupana, 23 Salvia divinorum, and 26 Hypericum perforatum. Garcinia cambogia was used more frequently by females (100% versus 0%), and Paullinia cupana and Salvia divinorum were used more frequently by males (61% versus 36% and 91% versus 9%, respectively). Abuse, driven by Salvia divinorum, was more common overall than misuse. Abuse was also more common among males than females (p <0.001). Use of these agents fluctuated over time. Overall, use trended down since 2010, except for Garcinia cambogia use. In 62 cases (73.8%), the medical outcome was minor or had no effect or was judged as nontoxic or minimally toxic. Clinical effects were most common with Paullinia cupana and Salvia divinorum. Treatment sites included emergency department (n = 33; 39.3%), non-healthcare facility (n = 24; 28.6%), admission to a health care facility (n = 8; 9.5%), and other/unknown (n = 19; 22.6%). CONCLUSIONS Abuse and misuse of these dietary supplements was uncommon, and outcomes were mild. Further research should be performed to determine use and outcomes of abuse/misuse of other dietary supplements in this population.

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Olanipekun, Titilope, Valery Effoe, Ganiat Adeogun, Agniezka Gaertig, Myrtle White, and Matthew Haney. "Severe non-exertional rhabdomyolysis from weight loss supplement in sickle cell trait: A perfect storm?" Case Reports in Internal Medicine 5, no. 1 (February 8, 2018): 35. http://dx.doi.org/10.5430/crim.v5n1p35.

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Exertional rhabdomyolysis from sickle cell trait has been documented. Also, cases of rhabdomyolysis from the use of weight loss supplements in the setting of sickle cell trait and exertion have been described. However, the role of sickle cell trait in non-exertional rhabdomyolysis is not clear. We present a case of severe non-exertional rhabdomyolysis from weight loss supplement in a patient with sickle cell trait.A 45-year-old African American female with sickle cell trait presented to the emergency department with two days history of fatigue and mild breathlessness. She also reported diarrhea and vomiting for five days before presentation. She admitted to taking Garcinia cambogia (a dietary supplement) for weight loss one week prior to the onset of symptoms. She denied alcohol or drug use, rigorous physical activity or trauma.She was dehydrated on examination. Laboratory values revealed markedly elevated serum creatine phosphokinase (CPK) and creatinine levels. Garcinia cambogia was discontinued and she was hydrated with intravenous fluids. Her CPK and creatinine levels significantly trended down and she was discharged home with no apparent sequelae.Our patient had multiple episodes of diarrhea and vomiting likely from the use of Garcinia cambogia. We believe she suffered non-exertional rhabdomyolysis from dehydration in the setting of sickle cell trait. Though dietary weight loss supplements are marketed as generally safe, this case suggests otherwise. We emphasize that clinicians routinely inquire about use of these supplements and provide appropriate counseling to patients on the adverse effects, especially among those with sickle cell trait.

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Mathew, B., B. Nyanthara, GithaE Mathew, and MM Shaneeb. "Diuretic activity of leaves of Garcinia cambogia in rats." Indian Journal of Pharmaceutical Sciences 73, no. 2 (2011): 228. http://dx.doi.org/10.4103/0250-474x.91567.

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Lunsford, Keri E., Adam S. Bodzin, Diego C. Reino, Hanlin L. Wang, and Ronald W. Busuttil. "Dangerous dietary supplements:Garcinia cambogia-associated hepatic failure requiring transplantation." World Journal of Gastroenterology 22, no. 45 (2016): 10071. http://dx.doi.org/10.3748/wjg.v22.i45.10071.

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Rocha Menezes, Rafaella Câmara, Juliana Crystal Schumacher, Anna Caroline Cristofoli Bertoletti, Larissa Slongo Faccioli, Jordana Boeira Freitas, Isabella Rosa da Mata, Kathleen Kruger Peres, Carine Fabiana Saul, Caroline Joana Kuyven, and Simone Morelo Dal Bosco. "Garcinia cambogia and diabetes mellitus: a lack of evidence?" International Physical Medicine & Rehabilitation Journal 6, no. 3 (May 2021): 67–68. http://dx.doi.org/10.15406/ipmrj.2021.06.00284.

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Thornby, Krisy-Ann, and Shawna Cargill. "Garcinia cambogia: Evidence for weight loss, lipid-lowering effects." Pharmacy Today 22, no. 1 (January 2016): 15. http://dx.doi.org/10.1016/j.ptdy.2015.12.009.

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Heymsfield, Steven B., David B. Allison, Joseph R. Vasselli, Angelo Pietrobelli, Debra Greenfield, and Christopher Nunez. "Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent." JAMA 280, no. 18 (November 11, 1998): 1596. http://dx.doi.org/10.1001/jama.280.18.1596.

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Mena-García, Adal, Angie Julieth Bellaizac-Riascos, Maite Rada-Mendoza, Diana María Chito-Trujillo, Ana Isabel Ruiz-Matute, and María Luz Sanz. "Quality Evaluation of Dietary Supplements for Weight Loss Based on Garcinia cambogia." Nutrients 14, no. 15 (July 27, 2022): 3077. http://dx.doi.org/10.3390/nu14153077.

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Food supplements of plant origin for weight control are increasingly being demanded by consumers as a way to promote good health. Among them, those based on Garcinia cambogia (GCFS) are widely commercialized considering their bioactive properties, mainly due to (-)-hydroxycitric acid ((-)-HCA). However, recently, controversy has arisen over their safety; thus, further research and continuous monitoring of their composition is required. Hence, in this work, a multi-analytical approach was followed to determine not only (-)-HCA but also other constituents of 18 GCFS, which could be used as quality markers to detect fraudulent practices in these samples. Discrepancies between the declared (-)-HCA content and that experimentally determined were detected by LC–UV in 33% of the samples. Moreover, GC–MS analyses of GCFS allowed the detection of different compounds not present in G. cambogia fruits and not declared on supplement labels, probably related to heat exposure or to the addition of excipients or other extracts. This multi-analytical methodology is shown to be advantageous to address different fraudulent practices affecting the quality of these supplements.

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AL-ASKALANY, SAMIA A. "EVALUATION OF GARCINIA CAMBOGIA PLANT EXTRACTS ANTIFUNGAL, ANTIBACTERIAL AND ANTIOXIDANT." Egyptian Journal of Agricultural Research 96, no. 1 (January 1, 2018): 121–34. http://dx.doi.org/10.21608/ejar.2018.130675.

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Koshy, Asha Sarah, L. Anila, and N. R. Vijayalakshmi. "Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats." Food Chemistry 72, no. 3 (February 2001): 289–94. http://dx.doi.org/10.1016/s0308-8146(00)00225-9.

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Abraham, Z., S. K. Malik, Gangadhar Eashwar Rao, S. Lakshmi Narayanan, and S. Biju. "Collection and Characterisation of Malabar Tamarind [Garcinia cambogia (Gaertn.) Desr.]." Genetic Resources and Crop Evolution 53, no. 2 (March 2006): 401–6. http://dx.doi.org/10.1007/s10722-004-0584-y.

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Lopez, Annette M., Joshua Kornegay, and Robert G. Hendrickson. "Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement." Journal of Medical Toxicology 10, no. 4 (April 4, 2014): 399–401. http://dx.doi.org/10.1007/s13181-014-0390-7.

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Cho, Xinyi, Patrick Nwabueze Okechukwu, Norazlina Mohamed, Gabriele Ruth Anisah Froemming, and Hor Kuan Chan. "Protective effect of Spirulina against bone fragility induced by Garcinia cambogia in high-fat diet induced obese rats." International Food Research Journal 29, no. 3 (June 30, 2022): 593–606. http://dx.doi.org/10.47836/ifrj.29.3.12.

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The present work evaluated the protective effects of Spirulina against the bone fragility caused by Garcinia cambogia in high-fat diet induced obese rats. High-fat diet and high-fat emulsion (HFD+HFE) were administered via oral gavage to 30 six-week-old female Sprague Dawley rats for six weeks to induce obesity, except for a normal group (n = 6). Following four weeks of treatment, the diet-induced obese groups were orally administered, daily, with (1) G. cambogia (GC); (2) Spirulina (S); and (3) G. cambogia + Spirulina (GC+S). The normal and obese control groups were treated with equal volumes of 0.9% saline water. It was found that GC significantly decreased body mass index (BMI) below the obese range (0.68 g/cm2). Additionally, GC altered bone mineral density (BMD), increased phosphate and calcium levels, and decreased maximum force and mineral apposition rates (MAR) as compared to the obese control group (p < 0.05). Bone fragility caused by GC was confirmed by the decrease in bone formation marker osteocalcin (OCN), as well as an increase in bone resorption receptor activator of nuclear factor kappa-B ligand (RANKL) and tartrate-resistant acid phosphatase type 5b (TRAP5b) as compared to the obese control group. Spirulina also decreased the BMI of the obese rats. Spirulina also increased blood bone markers, BMD, maximum force, and Young’s modulus. Rats supplemented with GC+S demonstrated higher double-labelled surface (dLS/BS) and MAR as compared to those in the GC group (p < 0.05). Meanwhile, the S group demonstrated improvement in all dynamic histomorphometric indices. S and GC+S groups demonstrated bone formation upregulation and bone resorption downregulation, thus indicating a bone protective effect of Spirulina. Overall, GC treatment led to bone fragility. GC+S treatment significantly augmented bone formation and mineralisation in obese rats as compared to the GC treatment alone. Rats in the S group demonstrated effective weight reduction while showing no destructive effects on the bone.

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Malik, S. K., R. Chaudhury, and Z. Abraham. "Desiccation-freezing sensitivity and longevity in seeds of Garcinia indica, G. cambogia and G. xanthochymus." Seed Science and Technology 33, no. 3 (October 1, 2005): 723–32. http://dx.doi.org/10.15258/sst.2005.33.3.20.

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A. N., Vijay Kumar, Vijay Thawani, and Lal Hingorani. "Effect of herbal combination of triphala and Garcinia cambogia extracts on liver function test and kidney function test in high fat diet induced obesity in rats." International Journal of Basic & Clinical Pharmacology 8, no. 12 (November 25, 2019): 2713. http://dx.doi.org/10.18203/2319-2003.ijbcp20195284.

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Background: Obesity, a global epidemic, is a major risk factor for diabetes mellitus and cardio vascular diseases. Despite advances, the pharmacotherapy for obesity remains limited. Almost all medications for long term management of obesity have health issues. Due to the adverse drug reactions (ADRs) associated with many antiobesity medicines, the clinical trials are focussing on screening herbal medicines for use in the treatment of obesity, which have minimal ADRs.Methods: Rats were divided into eight groups of six each. The rats were first made obese by feeding high fat diet (HFD) for three weeks. Then treatment with the herbal extracts was given simultaneously with the HFD to the experimental groups. Rats were fed HFD for six weeks along with herbal extracts and the effect on their liver function test and kidney function test were evaluated.Results: The rats fed HFD and supplemented with herbal preparations of Triphala and G. cambogia for six weeks, showed significant improvement in liver function test and kidney function test related parameters as compared to the control group rats fed with HFD alone.Conclusions: Triphala and G. cambogia can counter the effects of HFD intake and have the potential for use as anti-obesity agents with desirable liver function test and kidney function test related parameters modulating properties.

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Tharachand, C., C. Immanuel Selvaraj, and Z. Abraham. "Molecular Insights into the Genetic Diversity of Garcinia cambogia Germplasm Accessions." Brazilian Archives of Biology and Technology 58, no. 5 (October 2015): 765–72. http://dx.doi.org/10.1590/s1516-89132015050197.

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Kang, Eun Sil, Sun Ah Ham, Jung Seok Hwang, Chang-Kwon Lee, and Han Geuk Seo. "Effects of Garcinia cambogia Extract on the Adipogenic Differentiation and Lipotoxicity." Korean Journal for Food Science of Animal Resources 33, no. 3 (June 30, 2013): 411–16. http://dx.doi.org/10.5851/kosfa.2013.33.3.411.

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Afshan, Gul, Ponum Mirani, Imtiaz Aslam, and Sobia Ibrahim. "Effects of Garcinia Cambogia on the Weights of Normal Albino Mice." Pakistan Journal of Medical and Health Sciences 15, no. 11 (November 30, 2021): 2956–57. http://dx.doi.org/10.53350/pjmhs2115112956.

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Aim: Effects of available weight reducing drugs on the weights of a normal albino mice. Methodology: In this study, total 39 adult albino mice were used and were divided in three groups containing 13 animals in each. Group I served as control and was given 1 ml of distilled water once a day for 8 weeks. Group II and Group III served as experimental group and mice in these groups were given 0.5 mg of Slim Smart and Ultra Slim Plus drugs dissolved in 1 ml of distilled water respectively once a day for 8 weeks. To support these results weights of kidneys were also measured and relative tissue width index was calculated and compared with control group. Results: The weight of the animals increased in the experimental groups as compared to the control group. The overall difference for final weight among three groups was highly significant with p-value <0.01. When final weight compared group wise, the experimental groups had significantly higher weight as compared to control with p-values <0.01and 0.028 Conclusion: Both Ultra Slim Plus and Slim Smart drugs cause weight to increase in the individuals who are not obese and have BMI in normal range Keywords: Weight loss, Garcinia Cambodia, kidney, Albino mice

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