Dissertations / Theses on the topic 'Calcium and integrin binding protein'
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Blamey, Chad Joseph. "Calcium- and integrin-binding protein 1 structure and function /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 3.06 Mb., p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3220732.
Full textPrincipal faculty advisors: Ulhas P. Naik, Dept. of Biological Sciences and Brian J. Bahnson, Dept. of Chemistry and Biochemistry. Includes bibliographical references.
Maddox, Katherine. "A characterization of the calcium- and integrin-binding protein family." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 112 p, 2009. http://proquest.umi.com/pqdweb?did=1654487501&sid=7&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Full textRousset, Céline. "Étude de l'interaction entre le domaine cytoplasmique de l'intégrine [alpha]IIb et la "calcium- and integrin-binding protein (CIB)"." Lille 1, 2002. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2002/50376-2002-331.pdf.
Full textCeci nous a notamment permis de montrer que sur le peptide correspondant au domaine cytoplasmique de [alpha]IIb, l'interaction implique des résidus situés dans une séquence juxta-membranaire conservée entre les sous-unités alpha des intégrines (GFFKR). Cette séquence est justement importante pour une interaction de nature électrostatique et hydrophobe avec la séquence conservée juxta-membranaire des sous-unités bêta (LLxxxHDR). Ainsi, si une interaction entre les domaines cytoplasmiques des intégrines [alpha] et [bêta] permet le maintien d'un récepteur inactif (récepteur de faible affinité pour un ligand extracellulaire), alors en interagissant avec cette séquence conservée juxta-membranaire de la sous-unité [alpha]IIb, il est probable que CIB soit un des facteurs intracellulaire susceptible de supprimer cette interaction et ainsi susceptible de provoquer l'activation du récepteur (conversion du récepteur de basse affinité vers un récepteur de haute affinité pour un ligand extracellulaire), ou bien de le maintenir dans une conformation active (haute affinité pour le ligand). Selon nos résultats, l'affinité entre le peptide [alpha]IIb(Kexp. 989-Eexp. 1008) et le domaine C-terminal de CIB est faible. Cette donnée associée aux résultats d'une autre équipe de recherche selon laquelle il existe une forte affinité entre un peptide plus long [alpha]IIb(Lexp. 983-Eexp. 1008) et CIB suggère que CIB occupe très certainement un rôle dans le maintien d'une intégrine [alpha]IIb[bêta]3 activée plutôt que dans l'activation proprement dite du récepteur
Wang, Xue. "Predicting Protein Calcium Binding Sites." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/cs_diss/46.
Full textVosnidou, Nancy Carol Hoffman. "Computational analysis of cadherins : sequence analysis of dimerization properties and quantum caculations of calcium coordination characteristics /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3060154.
Full textBouissou, Camille. "Encapsulation of an integrin-binding protein into PLGA microspheres." Thesis, University of Bath, 2006. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432835.
Full textWalker, Simon W. "Studies on the intracellular calcium-binding protein calmodulin." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235957.
Full textRönning, Sanne. "Selection of a calcium-dependent IgG1-binding protein domain." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-417065.
Full textKumar, Mohit. "Cardiac Myosin Binding Protein-C phosphorylation Regulates Calcium Homeostasis." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin159584822092564.
Full textWoodard-Grice, Alencia V. "Hyposialylation regulates [alpha]4[beta]1 integrin binding to VCAM-1." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/woodard.pdf.
Full textKeselowsky, Benjamin George. "Engineering surfaces to direct integrin binding and signaling to promote osteoblast differentiation." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/8092.
Full textEllis, April L. "Rational Design of Calcium Biosensors." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/chemistry_diss/25.
Full textDavies, Michael Peter Alan. "Expression of the rat calcium-binding protein p9Ka in transgenic mice." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357240.
Full textStewart, Terence John. "Molecular characterization of Sm20, a calcium binding protein of Schistosoma mansoni." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239659.
Full textHou, Tien-tzu. "Role of intracellular calcium-binding protein parvalbumin in skeletal muscle function /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487676847116788.
Full textCastiblanco, Adriana P. "Expression and Purification of Engineered Calcium Binding Proteins." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_theses/20.
Full textMoes, Michèle. "Interaction of the cytoskeletal protein talin with the integrin beta3 subunit cytoplasmic tail: characterization of the talin rod IBS2 integrin binding site." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210658.
Full textIn the first part of this study, we used a combination of three different experimental approaches to define the minimal structure of talin IBS2: 1) an in silico bioinformatics approach to analyse sequence conservation of talin IBS2, 2) an in vivo cell biology approach to study the subcellular localization of recombinant talin fragments covering IBS2 in CHOáIIbâ3 cells, and 3) an in vitro biochemical approach consisting in protein overlay, pull down and Surface Plasmon Resonance (SPR) assays, to study the direct interaction between talin IBS2 and the integrin â3 subunit. We delineated IBS2 to a single amphipathic á-helical repeat of 23 residues within the talin rod domain. We further provided evidence that a two amino acid mutation(L2094I2095/AA) was sufficient to inactivate the IBS2 site, due to a disruption of the á helix structure, as demonstrated by infrared spectroscopy. In addition, we identified 2 lysine residues (K2085, K2089) exposed on the solvent face of á helix 50, which are directly involved in the talin IBS2-integrin interaction.
In the second part of this study, we investigated the functional role of talin IBS2 in spreading defective talin (-/-) cells and showed that in contrast to full-length wild type talin, an IBS2 LI/AA mutant talin was unable to fully rescue the spread phenotype of these cells. These results provide the first direct evidence that IBS2 in the talin rod is essential to link integrins to the actin cytoskeleton.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Allhouse, Leanne Dawn. "Characterisation of troponin C, the calcium binding protein of barnacle striated muscle." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312246.
Full textBaker, Christian. "Developmental challenge and GABAergic neuronal abnormalities : their relevance to schizophrenia." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274951.
Full textWilliams, James M. A. "Studies on the transport of calcium across the dually perfused lobule of the human term placenta." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387461.
Full textJones, Lisa Michelle. "Using Protein Design to Understand the Role of Electrostatic Interactions on Calcium Binding Affinity and Molecular Recognition." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/chemistry_diss/16.
Full textChen, Shan. "Histidine-Rich Ca Binding Protein and Cardiac Functions." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242973363.
Full textSkene, Robert J. "Crystallographic studies of calcium-binding proteins, aeromonas salmonicida surface array protein and calmodulin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ64978.pdf.
Full textPalmer, Claire Louise. "Biochemical investigation into the function of hippocalcin, a neurone-specific calcium binding protein." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271880.
Full textSwan, David Gerard. "The structural gene for a calcium-binding protein from Saccharopolyspora erthyraea (Streptomyces erthyreus)." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316010.
Full textBirkholz, Tyler M. "Exploring the Role of Calcium-Binding Protein Calreticulin in the Mouse Suprachiasmatic Nucleus." Bowling Green State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1562689789471245.
Full textTessarolo, Diane. "Cytoskeletal localization and function of calcium-binding protein 1 (CBP1) during Dictyostelium discoideum development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/MQ59208.pdf.
Full textGumpel, Nicola Jane. "Characterisation of uroporphyrinogen III synthase and a novel calcium binding protein from Euglena gracilis." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386737.
Full textRajamanoharan, Dayani. "Investigating calcium binding protein 7 (CaBP7), phosphoinositide signalling and lysosomes during mammalian cell mitosis." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2044661/.
Full textChen, Yanyi. "Dissecting Key Determinants for Calcium and Calmodulin Regulation of GAP Junction and Viral Protein." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/chemistry_diss/64.
Full textAgah, Sayeh. "Parvalbumin stability and calcium affinity : the impact of the n-terminal domain /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?3164486.
Full textEastlake, Jane Louise. "Calmodulin from the eucestoda Hymenolepis diminuta : an investigative study." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387426.
Full textClark, Ruti H. "A model system for investigating biomineralization : elucidating protein G/calcium oxalate monohydrate interactions /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8067.
Full textGagné, Stéphane M. "Structures, dynamics and energetics of troponin C, the tale of a muscular calcium-binding protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0023/NQ39528.pdf.
Full textSchacht, Teresa [Verfasser]. "Neuronal calcium-binding protein 2 (NECAB2): Charakterisierung eines striatalen Ca 2+ -bindenden Proteins / Teresa Schacht." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1141937689/34.
Full textKim, Kristin. "Characterization of calcium binding protein 1 (CaBP1/CD) expression and localization in the mouse brain." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/2545.
Full textJones, Lisa Michelle. "Using protein design to understand the role of electrostatic interactions on calcium binding affinity and molecular recognition." unrestricted, 2006. http://etd.gsu.edu/theses/available/etd-07282006-143357/.
Full textTitle from file title page. Jenny J. Yang, committee chair; Alfons Baumstark, Giovanni Gadda, committee members. Electronic text (405 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Aug. 20, 2008. Includes bibliographical references (p. 380-405).
Prichard, Lisa. "The role of the IQ motif, a protein kinase C and calmodulin regulatory domain, in neuroplasticity, RNA processing, and RNA metabolism /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6302.
Full textDharamsi, Akil G. "Studies on the function of Calcium Binding Protein 1 (CBP1) during the development of Dictyostelium discoideum." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ27345.pdf.
Full textCasey, Diane M. "DC3, a Calcium-Binding Protein Important for Assembly of the Chlamydomonas Outer Dynein Arm: a Dissertation." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/156.
Full textRipley, Scott James. "Biochemical characterisation and subcellular localisation of the ARP : a novel calcium-binding protein from Euglena gracilis." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627242.
Full textWang, Lianyong. "A calcium-binding protein CAS regulates the CO2-concentrating mechanism in the green alga Chlamydomonas reinhardtii." Kyoto University, 2017. http://hdl.handle.net/2433/218025.
Full textCasey, Diane M. "DC3, a Calcium-Binding Protein Important for Assembly of the Chlamydomonas Outer Dynein Arm: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/156.
Full textTatsumi, Keiji. "Expression of calcium binding protein D-9k messenger RNA in the mouse uterine endometrium during implantation." Kyoto University, 1999. http://hdl.handle.net/2433/181740.
Full textConnors, Wendy Lee. "Sequential injection analysis for the investigation of biomolecular interactions /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8481.
Full textBanjo, Taiwo Abayomi. "Acanthamoeba mannose-binding protein : structural and functional characterisation of a therapeutic target for Acanthamoeba keratitis." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42327.
Full textXie, Yi. "Metastasis and angiogenesis in neuroblastoma involvement of visinin like protein-1 and dendritic cell /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38588250.
Full textXie, Yi, and 謝弋. "Metastasis and angiogenesis in neuroblastoma: involvement of visinin like protein-1 and dendritic cell." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38588250.
Full textLee, Hsiau-Wei. "Determining The Site Specific Metal Binding and Structural Properties of EF-Hand Protein Using Grafting Approach." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/chemistry_diss/26.
Full textChen, Xi Lin. "Régulation de l'apoptose des lymphocytes T par GIMAP5 (GTPase of Immune Associated Nucleotide Binding Protein 5)." Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/7593.
Full textRésumé : La survie à long terme des lymphocytes T en état de repos est essentielle pour maintenir leurs nombres dans les organes lymphoïdes secondaires. Le récepteur antigénique des cellules T (TCR) en contact avec les peptides du soi / CMH et en synergie avec l'IL-7 induit des signaux anti-apoptotiques pour favoriser la survie des cellules T. Ces stimuli extrinsèques sont également impliqués dans le métabolisme et la survie des cellules T grâce à la régulation de plusieurs voies de signalisation dont la voie phosphatidyl-inositol-3 kinase (PI3K) /AKT. Chez la souris et chez le rat, la perte de l’activité de GIMAP5 (GTPase of Immune Associated Nucleotide Binding Protein 5), provoque une lymphopénie T périphérique en raison de la mort spontanée des cellules T. Le mécanisme sous-jacent responsable de la fonction de survie de GIMAP5 dans les lymphocytes T reste largement inconnu. Nous avons observé que les cellules de rats déficients en GIMAP5, après stimulation par complexe TCR, montrent un afflux de calcium (Ca[indice supérieur 2+]) réduit provenant du milieu extracellulaire. Dans cette thèse, J’ai caractérisé le mécanisme d’action de GIMAP5 dans la régulation de l'homéostasie du Ca[indice supérieur 2+], ainsi que les voies de signalisation modulées par GIMAP5 pour faciliter la survie des cellules T. Tout d'abord, j’ai étudié si GIMAP5 empêche l’apoptose des lymphocytes T en affectant la capacité des mitochondries à réguler la concentration du Ca[indice supérieur 2+], ce qui est nécessaire pour soutenir l’influx de Ca[indice supérieur 2+]. J’ai trouvé que l’accumulation du Ca[indice supérieur 2+] mitochondrial après l’entrée capacitive de Ca[indice supérieur 2+] est défectueuse dans les cellules T de rat déficientes en Gimap5. La disruption des microtubules, mais pas du cytosquelette d'actine, abroge la séquestration du Ca[indice supérieur 2+] mitochondrial dans les cellules T primaires de rat, mais pas dans les cellules T déficientes en Gimap5. J’ai observé que les cellules T provenant de souris déficientes en Gimap5 démontrent une diminution de l’entrée de Ca[indice supérieur 2+]. De plus, la prolifération des cellules T déficientes en Gimap5 est diminuée suite à la stimulation du TCR. En outre, la phosphorylation de STAT5 induit par l'IL-7 est diminuée dans les cellules T CD4[indice supérieur +] de souris déficientes en Gimap5. Également, la perte de Gimap5 aboutit à une activation accrue de la cible mammalienne de la rapamycine (mTOR), indépendamment de la protéine phosphatase 2A (PP2A) ou de la protéine kinase activée par l'AMP (AMPK). Au lieu de cela, l'activation constitutive de la voie PI3K contribue à une forte activation spontanée de mTOR. Collectivement, la fonction de survie de GIMAP5 dans les lymphocytes T peut être liée à la régulation de différentes voies de signalisation. GIMAP5 facilite la fonction, microtubule dépendant, des mitochondries dans leurs actions de régulation du Ca[indice supérieur 2+] après l’entrée capacitive de Ca[indice supérieur 2+]. GIMAP5 est nécessaire pour intégrer les signaux de survie produits suite à l'activation du TCR et de l’IL-7R, qui pourrait être associée à la régulation de l'activité PI3K / AKT / mTOR.