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Dissertations / Theses on the topic 'Caenorhabditis elegans – Système nerveux'

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Published: 25 May 2024

Last updated: 31 July 2025

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1

Sauvage, Pascal. "Etude de la locomotion chez C. Elegans et perturbations mécaniques du mouvement." Paris 7, 2007. http://www.theses.fr/2007PA077110.

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Cette étude sur la locomotion de C. Elegans vise à mieux comprendre le fonctionnement de son système nerveux et à apporter des éléments nouveaux de réflexion pour la conception de modèles ou d'objet biomimétiques. Ce travail débute par une description du ver, de sa physiologie ainsi que des principaux modes de locomotion connus : la nage (en milieu liquide) et la reptation (sur gel aqueux). Puis dans le cas de la nage, nous mettons en évidence une dissymétrie du mouvement, nécessaire pour la progression en milieu visqueux. L'analyse des vitesses des déplacements locaux permet de faire un bilan

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2

Millet, Jonathan. "Stratégies d'analyse spatio-temporelle de l‟épissage alternatif chez Caenorhabditis elegans." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0437/document.

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L‟épissage alternatif est un mécanisme de régulation de l‟expression des gènes ayant pris une importance croissante dans l‟étude du vivant. Si des méthodes existent pour déterminer les gènes qui y sont soumis, peu d‟outils sont disponibles pour suivre ces événements d‟épissage in vivo au cours du développement. Pourtant, la caractérisation des régulations sous-jacentes à ces évènements et la détermination des facteurs impliqués sont dépendantes de stratégies fiables pour les visualiser dans des conditions physiologiques.Nous avons développé un système adapté à l‟étude d‟événements d‟épissage b

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3

Dichio, Vito. "The exploration-exploitation paradigm : a biophysical approach." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS402.

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L'étude des systèmes vivants est notoirement difficile. La complexité déconcertante des systèmes biologiques, souvent citée, est principalement due à la complexité de leurs interactions, à leurs multiples niveaux d'organisation et à leur nature dynamique. Dans la quête de compréhension de cette complexité, les parallèles établis avec la physique standard - en particulier la physique statistique - sont à la fois utiles et d'une utilité limitée. D'une part, ils fournissent un riche ensemble d'éléments théoriques et méthodologiques pour construire des théories et concevoir des expériences. D'autr

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4

Livingstone, David. "Studies on the unc-31 gene of Caenorhabditis elegans." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240106.

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5

Lee, Yuk Wa. "Characterization of Mab21l2 in neural development of vertebrate model /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202005%20LEEY.

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6

Birnby, Deborah Ann. "Analysis of daf-11, a transmembrane guanylyl cyclase that mediates chemosensory transduction in C. elegans /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/10300.

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7

Stovall, Elizabeth L. "Analysis of mig-10, a gene involved in nervous system development in caenorhabditis elegans." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0430104-142249/.

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8

Ficociello, Laura Faraco. "Neuronal migration -- investigating interactions of the cytoplasmic adaptor pProtein MIG-10 in C. elegans." Worcester, Mass. : Worcester Polytechnic Institute, 2008. http://www.wpi.edu/Pubs/ETD/Available/etd-010908-103637/.

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9

Burket, Christopher T. "Two genes, dig-1 and mig-10, involved in nervous system development in C. elegans." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-1115102-141010.

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10

Lau, Tze Chin. "In vitro and in vivo analyses of the impact of Mab21l2 and its targets on neural patterning and differentiation in vertebrates /." View abstract or full-text, 2010. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202010%20LAU.

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11

Dumesnil, Dennis. "Neurological Responses to a Glucose Diet in Caenorhabditis elegans." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1011786/.

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TRPV channels play a role in both mammalian insulin signaling, with TRPV1 expression in pancreatic beta-cells, and in C. elegans insulin-like signaling through expression of OSM-9, OCR-1, and OCR-2 in stress response pathways. In response to a glucose-supplemented diet, C. elegans are know to have sensitivity to anoxic stress, exhibit chemotaxis attraction, and display reduced egg-laying rate. Transcriptome analysis reveals that glucose stimulates nervous system activity with increased transcript levels of genes regulating neurotransmitters. Ciliated sensory neurons are needed for a reduced eg

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12

Hoskins, Roger Allen. "Molecular and genetic studies on the unc-30 and unc-31 genes of Caenorhabditis elegans." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334107.

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13

Khandekar, Anagha. "Age-related Changes in the Neuronal Architecture of Caenorhabditis Elegans: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/798.

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Though symptoms such as loss of vision, decline in cognition and memory are evident during aging, the underlying processes that affect neuronal function during aging are not well understood. Unlike changes in other tissues and organs, age-related changes in the nervous system affect the overall physical, mental as well as social state of human beings. To start elucidating the molecular mechanisms underlying normal age-dependent brain decline, we have characterized structural neuronal changes occurring during Caenorhabditis elegans aging. Our analysis reveals distinct neuronal alterations that

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14

Khandekar, Anagha. "Age-related Changes in the Neuronal Architecture of Caenorhabditis Elegans: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/798.

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Though symptoms such as loss of vision, decline in cognition and memory are evident during aging, the underlying processes that affect neuronal function during aging are not well understood. Unlike changes in other tissues and organs, age-related changes in the nervous system affect the overall physical, mental as well as social state of human beings. To start elucidating the molecular mechanisms underlying normal age-dependent brain decline, we have characterized structural neuronal changes occurring during Caenorhabditis elegans aging. Our analysis reveals distinct neuronal alterations that

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15

Belicard, Tony. "Base génétique de la sensibilité au virus d'Orsay au sein des populations naturelles de Caenorhabditis elegans." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066274/document.

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Caenorhabditis elegans fait partie des modèles animaux les plus étudiés en laboratoire. La découverte des premiers virus infectant naturellement des Caenorhabditis apporte de nouveaux modèles animal-virus très prometteurs.Le virus d'Orsay, infectant spécifiquement C. elegans, et le virus de Santeuil, infectant spécifiquement C. briggsae, sont des virus à ARN positif simple brins (Hépatites A, C et E, Chikungunya, Coronavirus etc¿) qui provoquent une désorganisation de la structure des cellules intestinales de leur hôte. Par ailleurs, une variation dans la sensibilité à ce virus au sein des esp

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16

Soltesz, Zoltan. "Optogenetic investigation of the neural network underlying the oxygen modulation of C. elegans locomotion." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708419.

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17

Clark, Christopher M. "Neural Orchestration of the C. elegans Escape Response: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/750.

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How does a nervous system orchestrate compound behaviors? Finding the neural basis of behavior requires knowing which neurons control the behavior and how they are connected. To accomplish this we measured and manipulated neural activity in a live, behaving animal with a completely defined connectome. The C. elegans escape response is a compound behavior consisting of a sequence of behavioral motifs. Gentle touch induces a reversal and suppression of head movements, followed by a deep turn allowing the animal to navigate away from the stimulus. The connectome provides a framework for the neura

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18

Clark, Christopher M. "Neural Orchestration of the C. elegans Escape Response: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/750.

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How does a nervous system orchestrate compound behaviors? Finding the neural basis of behavior requires knowing which neurons control the behavior and how they are connected. To accomplish this we measured and manipulated neural activity in a live, behaving animal with a completely defined connectome. The C. elegans escape response is a compound behavior consisting of a sequence of behavioral motifs. Gentle touch induces a reversal and suppression of head movements, followed by a deep turn allowing the animal to navigate away from the stimulus. The connectome provides a framework for the neura

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19

Quéré, Cécile. "Régulation post-transcriptionnelle du gène unc-54 de Caenorhabditis elegans identifiée in vivo par un système de double rapporteurs fluorescents." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0347/document.

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Le développement de Caenorhabditis elegans est finement régulé et aboutit au nombre constant de 959 cellules par individu. Une partie de ces régulations repose sur les microARN, ARN simple brin d’environ 22 nucléotides. Ils peuvent diminuer l'expression des gènes en ciblant des séquences homologues dans les régions 3' non transcrites (3'UTR) des ARN messagers. Pour déterminer l'impact de cette régulation, nous utilisons une méthode permettant de visualiser in vivo une différence d'expression induite post-transcriptionnellement. Cette méthode se base sur l'utilisation de deux protéines fluoresc

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20

Ameen, Muhammad T., and Patrick C. Bradshaw. "VITAMIN B2 REDUCES AMYLOID-BETA PROTEOTOXICITY AND IMPROVES HEALTH IN A CAENORHABDITIS ELEGANS ALZHEIMER’S DISEASE MODEL." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/24.

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Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia associated with amyloid-beta peptide deposition and loss of mitochondrial function and regulation. Currently, there is no cure for AD, thus, there is a need to continuously develop therapeutic strategies that could address the complex multifactorial causes of AD development. Due to this necessity, this study has investigated the role of vitamin B2 as a disease modifying drug for AD by employingamyloid-beta and mitochondrial based AD therapeutic strategies. Using a transgenic C. elegans AD worm model ex

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21

Ameen, Muhammad Tukur. "A Role of Vitamin B2 in Reducing Amyloid-beta Toxicity in a Caenorhabditis elegans Alzheimer’s Disease Model." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3398.

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Alzheimer’s disease (AD) is associated with amyloid-beta peptide deposition and loss of mitochondrial function. Using a transgenic C. elegans AD worm model expressing amyloid-beta in body wall muscle, we determined that supplementation with either of the forms of vitamin B2, flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD) protected against amyloid-beta mediated paralysis. FMN and FAD were then assayed to determine effects on ATP, oxygen consumption, and reactive oxygen species (ROS) with these compounds not significantly improving any of these mitochondrial bioenergetic functi

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22

Ficociello, Laura Faraco. "Neuronal Migration: Investigating Interactions of the Cytoplasmic Adaptor Protein MIG-10 in C. elegans." Digital WPI, 2008. https://digitalcommons.wpi.edu/etd-theses/41.

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Neuronal migration is an essential aspect of nervous system development; improper or incomplete neuronal migration can lead to debilitating disorders. The model organism Caenorhabditis elegans has 302 neurons and is ideal for studying nervous system development. The cytoplasmic adaptor protein, MIG-10, is necessary for the long range anteroposterior migration during embryogenesis of the neurons CAN, ALM, and HSN. Mutations in the mig-10 gene result in incomplete migrations of all three neurons. MIG-10 is a homologue of the vertebrate proteins lamellipodin and RIAM-1, which are involved in d

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23

Belicard, Tony. "Base génétique de la sensibilité au virus d'Orsay au sein des populations naturelles de Caenorhabditis elegans." Electronic Thesis or Diss., Paris 6, 2014. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2014PA066274.pdf.

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Caenorhabditis elegans fait partie des modèles animaux les plus étudiés en laboratoire. La découverte des premiers virus infectant naturellement des Caenorhabditis apporte de nouveaux modèles animal-virus très prometteurs.Le virus d'Orsay, infectant spécifiquement C. elegans, et le virus de Santeuil, infectant spécifiquement C. briggsae, sont des virus à ARN positif simple brins (Hépatites A, C et E, Chikungunya, Coronavirus etc¿) qui provoquent une désorganisation de la structure des cellules intestinales de leur hôte. Par ailleurs, une variation dans la sensibilité à ce virus au sein des esp

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24

Showemimo, Opeyemi F. "Vitamin B12 Deficiency Does Not Stimulate Amyloid-beta Toxicity in a Ceanorhabditis elegans Model of Alzheimer’s Disease." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3869.

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Alzheimer’s disease (AD) is symptomized by amyloid-beta plaques in the brain and accounts for more than 65 percent of dementia cases. Vitamin B12 (cobalamin) deficiency can result in similar cognitive impairment and roughly 15% of the elderly are vitamin B12 deficient. Vitamin B12 deficiency results in the accumulation of toxic methylmalonic acid and homocysteine. Hyperhomocysteinemia is a strong risk factor for AD. To test if vitamin B12 deficiency stimulates amyloid-beta toxicity, Caenorhabditis elegans expressing amyloid-beta in muscle were fed either vitamin B12-deficient OP50-1 or vitamin

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25

Petrash, Hilary A. "Maintaining the Balance: Coordinating Excitation and Inhibition in a Simple Motor Circuit: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/633.

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The generation of complex behaviors often requires the coordinated activity of diverse sets of neural circuits in the brain. Activation of neuronal circuits drives behavior. Inappropriate signaling can contribute to cognitive disorders such as epilepsy, Parkinson’s, and addiction (Nordberg et al., 1992; Quik and McIntosh, 2006; Steinlein et al., 2012). The molecular mechanisms by which the activity of neural circuits is coordinated remain unclear. What are the molecules that regulate the timing of neural circuit activation and how is signaling between various neural circuits achieved? While mu

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26

Desbois, Muriel. "Dynamic synaptic changes revealed by a novel trans-synaptic method to visualize connections in vivo in C. elegans." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066157/document.

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Le système nerveux est un réseau complexe qui détecte et analyse les informations. Ces informations sont transmises entre cellules grâce à des connections synaptiques et des jonctions communicantes. Ce réseau n’est pas statique et évolue au cours du développement, de l’apprentissage mais aussi durant le processus de vieillissement – naturels ou pathologiques. Comprendre le système nerveux et son fonctionnement requiert une analyse des connections synaptiques in vivo chez un animal model tel que Caenorhabditis elegans. Cependant les techniques actuellement disponibles pour C. elegans sont labor

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27

Squiban, Barbara. "Criblage par ARN interférence du génome complet de C. elegans pour l' identification de nouveaux gènes impliqués dans l' immunité innée." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4056.

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Afin de caractériser les voies de signalisation du système immunitaire inné, nous étudions l'interaction entre le ver C. elegans et le champignon Drechmeria coniospora. Une des réponses du ver à l'infection consiste en une augmentation de la production de peptides antimicrobiens (PAM) dans l'épiderme. Des vers transgéniques exprimant le gène rapporteur de la GFP sous le contrôle du promoteur d'un PAM, fluorescent vert après infection. Si un gène nécessaire à l'expression des PAM est inactivé, alors les vers transgéniques ne fluorescent plus après infection. Nous avons effectué un crible pour i

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28

Sleigh, James Nicholas. "Model systems for exploring new therapeutic interventions and disease mechanisms in spinal muscular atrophies (SMAs)." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:378416c5-a586-4a2a-980c-81dfff6803df.

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Spinal muscular atrophy (SMA) and Charcot-Marie-Tooth disease type 2D (CMT2D)/distal SMA type V (dSMAV) are two incurable neuromuscular disorders that predominantly manifest during childhood and adolescence. Both conditions are caused by mutations in widely and constitutively expressed genes that encode proteins with essential housekeeping functions, yet display specific lower motor neuron pathology. SMA results from recessive inactivating mutations in the survival motor neuron 1 (SMN1) gene, while CMT2D/dSMAV manifests due to dominant point mutations in the glycyl-tRNA synthetase (GlyRS) gene

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29

Berghoff, Emily Greta. "Circuit transcription factors in Caenorhabditis elegans." Thesis, 2020. https://doi.org/10.7916/d8-77a8-5z43.

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Many neuronal patterning genes are expressed in distinct populations of cells in the nervous system, leading researchers to analyze their function in specific isolated cellular contexts that often obscure broader, themes of gene function. In this thesis, I aim to make clearer those overlooked common functional themes. I show that the C. elegans homeobox gene unc-42 is expressed in 15 out of a total of 118 distinct sensory, inter, and motor neuron classes throughout the C. elegans nervous system. Of these 15 unc-42(+) synaptically interconnected neuron classes, I show the extent to which unc-42

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30

Bayer, Emily Ann. "Sexually Dimorphic Development of the Caenorhabditis elegans Nervous System." Thesis, 2020. https://doi.org/10.7916/d8-kcqy-1e23.

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Sexual reproduction is an evolutionary innovation that arose 1.2 billion years ago, and in that time, has allowed a rapid diversification of species outpacing that of asexually reproducing organisms. Successful sexual reproduction in animals requires the incredible coordination of complex genetic and behavioral factors; from the most fundamental levels of ensuring correct chromosome segregation and ploidy to the most complex of behavioral mating rituals, any failure can result in a complete loss of evolutionary fitness. In this thesis, I have explored the developmental programs that function t

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31

Weinberg, Peter J. "Mechanisms of sexually dimorphic development in the nervous system of Caenorhabditis elegans." Thesis, 2017. https://doi.org/10.7916/D8N302MV.

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The advent of sexual reproduction in early evolutionary history had profound effects on the evolution of animals. In most sexually reproducing species, males and females have distinct morphological and behavioral differences that are shaped by the evolutionary imperatives of each sex. Underlying the behavioral differences between males and females are distinct and measurable dimorphisms in the nervous system. These dimorphisms can arise in the form of connectivity, neurotransmitter usage, gene expression or combinations of all three. The androdioecious nematode Caenorhabditis elegans, with its

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32

Barbier, Louis Wei-Chun. "The Stomatin STO-6 is a Novel Regulator of the Caenorhabditis elegans Motor Circuit." Thesis, 2012. http://hdl.handle.net/1807/42383.

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The ability to move is essential to an animal’s ability to interact with and respond to its changing environment. The nematode Caenorhabditis elegans is a commonly used organism in the study of the genetic and neural bases of behaviours, yet the mechanistic explanation for its ability to move in a smooth sinusoidal wave remains elusive. Here, I present studies of an uncharacterized gene, sto-6, encoding a stomatin protein that regulates C. elegans motor behaviour. I show that this gene plays a role in two unexplained and fundamental processes to C. elegans locomotion: wave initiation and wave

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33

VanDuyn, Natalia M. "Identification and characterization of molecular modulators of methylmercury-induced toxicity and dopamine neuron degeneration in Caenorhabditis elegans." Thesis, 2014. http://hdl.handle.net/1805/5193.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Methylmercury (MeHg) exposure from occupational, environmental and food sources is a significant threat to public health. MeHg poisonings in adults may result in severe psychological and neurological deficits, and in utero exposures can confer significant damage to the developing brain and impair neurobehavioral and intellectual development. Recent epidemiological and vertebrate studies suggest that MeHg exposure may contribute to dopamine (DA) neuron vulnerability and the propensity to develop Parkinson’s disease (PD). I have deve

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34

LeVora, Jennifer K. "THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS." Thesis, 2012. http://hdl.handle.net/1805/3177.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The etiology of many neurodegenerative diseases is unknown, but a number of studies indicate that a combination of both genetic and environmental factors contribute to the progression of disease. Exposure to environmental metals, such as Mn2+, Fe2+, Cu2+, and Al3+, has been shown to increase cell death that is characteristic of neurodegenerative disorders such as AD, PD, Wilson’s disease and Menkes disease. These metals are important in numerous biological processes in the brain and their homeostasis is regulated through multiple m

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