Dissertations / Theses on the topic 'Ca2+ exchanger'
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Parnis, Julia [Verfasser]. "The physiological role of mitochondrial Na+/Ca2+ exchanger NCLX for glial Ca2+ homeostasis / Julia Parnis." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1031099506/34.
Full textZhao, Jun, and e52677@ems rmit edu au. "The functional study of Na+/Ca2+ exchanger in vascular smooth muscle cells." RMIT University. Medical Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080617.163746.
Full textPRITCHARD, TRACY J. "Expression and Function of the Na +-K +ATPase α-Isoforms in Smooth Muscle: Evidence from Transgenic Mice." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186672962.
Full textBarman, Palash Pratim. "β-adrenoceptor/protein kinase A modulation of rabbit cardiac Na+-Ca2+ exchanger and cystic fibrosis transmembrane conductance regulator." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617927.
Full textNakamura, Toshio. "Expression of the Na+/Ca2+ exchanger emerges in hepatic stellate cells after activation in association with liver fibrosis." Kyoto University, 1998. http://hdl.handle.net/2433/182267.
Full textStabelini, Tatiana Comporte. "Estudos estruturais de fragmentos do trocador de Na+/Ca2+ por RMN em solução." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11122018-091550/.
Full textMembrane proteins are involved in essential physiological processes such as maintenance of the ionic balance and intracellular signaling. However, despite their role in numerous physiological processes of well-recognized pharmaceutical relevance, structural studies of membrane proteins remain being more complex than structural studies of globular proteins. Na+/Ca2+ exchangers (NCX) are membrane proteins that play essential roles in the maintenance of the intracellular Ca2+ homeostasis. Not surprisingly, the NCXs are involved in pathologies such as heart diseases. These exchangers are present in several species of mammals (NCX) and insects, for example, in the fly Drosophila melanogaster (CALX). The topology of these proteins consists of a transmembrane and a hydrophilic domain. The transmembrane domain corresponds to two segments of 5 transmembrane helices (TMH) forming a 10-helix bundle that is responsible for the specific transport of Ca2+ and Na+ across the cellular membrane. The hydrophilic domain is composed of a large cytoplasmic loop, which is associated with the regulation of the ion exchange activity of the transmembrane domain. The loop contains two Ca2+-sensors domains, CBD1 and CBD2, and uncharacterized regions. Studies showed that Ca2+ binding to CBD1 inhibits the CALX, whereas it activates the NCX. The juxtamembrane cytosolic regions linking the CBD1 and CBD2 domains to the TMH5 and TMH6, respectively, are highly conserved but have not yet been structurally characterized. The segment near TMH5 is amphipathic, and it is also called exchanger inhibitory peptide (XIP). In the absence of a three-dimensional structure of the complete CALX, the study of TMH5-XIP may contribute to our understanding of the structure and operation of the exchanger. In order to study TMH5-XIP, it was fused to an MBP tag at the N-terminus, and to a sequence of 8 histidines at the C-terminus. Although the expression of the fusion protein was successful, precipitation and inefficient MBP-tag cleavage prevented the isolation of pure TMH5-XIP for structural studies. Hence, a smaller construct, containing only the region equivalent to XIP, was studied by NMR spectroscopy in solution and circular dichroism. The structure assumed by XIP in solution is temperature dependent, being intrinsically disordered at 27 C or a 310-helix at 7 C, respectively. These findings allowed us to infer how XIP could participate in the CALX regulation mechanism.
Hammann, Jens [Verfasser]. "Influence of Na+, K+-ATPase and Na+/Ca2+ exchanger on developmental ion signaling and MBP synthesis in murine oligodendrocyte precursor cells / Jens Hammann." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/1163416274/34.
Full textAl, Maghout Tamer [Verfasser]. "P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes / Tamer Al Maghout." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1221596780/34.
Full textAbiko, Layara Akemi. "Estudo da dinâmica funcional dos domínios regulatórios do trocador de Na+/Ca2+ de Drosophila melanogaster por ressonância magnética nuclear em solução." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-20072015-115123/.
Full textThe Na+/Ca2+ exchanger (NCX) is a major mechanism for the extrusion of intracellular Ca2+ in excitable cells. It was demonstrated that altered functioning of this protein is related to various pathological situations. Therefore, the understanding of the molecular mechanism for maintaining the intracellular Ca2+ concentration by means of the NCX is important to understand the functioning of the exchanger and to develop drug-based therapies. Besides transporting Na+/Ca2+, the exchanger is also regulated by these ions. The NCX is composed of two transmembrane domains, each of them containing 5 transmembrane alpha-helices (TM), and a very large cytosolic loop that connects TM5 to TM6. The transmembrane domains are responsible for catalyzing the transport of Na+ and Ca2+ ions across the lipid bilayer, while the cytosolic loop is involved in regulation of the exchanger activity. It contains two regulatory Ca2+- binding domains, called CBD1 and CBD2, that appear in tandem. Despite the physiological importance of the NCX, the mechanism of allosteric regulation of the exchanger by intracellular calcium remains unclear. In this work we used high-resolution NMR spectroscopy to study the conformation and the dynamics of the two Ca2+-binding regulatory domains of Drosophila\'s Na+/Ca2+ exchanger (CALX), CBD1 and CBD2, in isolation as well as in a covalent construct called CBD12. Complete backbone NMR resonance assignments were obtained for the isolated CBD1 domain in the Ca2+-bound state, while partial assignments were obtained for CBD1 in the free state. Partial backbone NMR resonance assignments were obtained for the CBD12 construct through the analysis of a standard set of triple resonance NMR spectra. Additional assignments were obtained by comparison with the isolated CBD1 and CBD2 domains. A preliminary analysis of NMR chemical shifts and 15N relaxation data obtained for CBD1 indicates that this domain displays considerable amount of flexibility in the free state, but becomes more rigid upon Ca2+-binding. NMR 15N relaxation rates and 1H-15N residual dipolar couplings (RDCs) obtained for the Apo and Ca2+-bound states of the CBD12 domain indicate that calcium binding stabilizes a rigid inter-domain orientation. Analysis of 1H-15N RDCs further shows that Drosophila\'s CBD12 domain assumes an almost linear inter-domain orientation in the absence of Ca2+, while a smaller inter-domain angle was found in its presence. These findings support a model in which modulation of CBD12 plasticity by the binding of Ca2+ to the CBD1 domain controls the opening and closing of the exchanger.
Park, Seok-min. "Advanced data exchange for solid freeform fabrication /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004352.
Full textJohnson, Chad A. "The integration of CAD/CAM with virtual machining simulation and cost estimation." Ohio : Ohio University, 1997. http://www.ohiolink.edu/etd/view.cgi?ohiou1177434959.
Full textBöhme, Carsten, and Klaus Brökel. "Konzept zum Parameteraustausch zwischen unterschiedlichen CAD/CAE-Plattformen." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-228848.
Full textBöhme, Carsten, and Klaus Brökel. "Konzept zum Parameteraustausch zwischen unterschiedlichen CAD/CAE-Plattformen." TUDpress - Verlag der Wissenschaften GmbH, 2012. https://tud.qucosa.de/id/qucosa%3A30535.
Full textSharma, Vishal. "Functional Characterization of Na+/Ca2+ Exchangers in Caenorhabditis elegans." Thesis, The George Washington University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10262140.
Full textNa+/Ca2+ exchangers are low affinity/high capacity transporters that mediate Ca2+ extrusion by coupling Ca2+ efflux to the influx of Na+ ions. Their primary function is to maintain Ca2+ homeostasis in cells of all organisms and they play a particularly important role in excitable cells that experience transient Ca2+ fluxes. While their functions have been studied extensively in muscle cells, much is still unknown about their contributions to the nervous system. Data suggests that Na+/Ca 2+ exchangers play a key role in neuronal processes such as memory formation, learning, oligodendrocyte differentiation and axon guidance. They are also implicated in pathologies such as Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis and Epilepsy. While they are implicated in critical neuronal processes, a clear understanding of their mechanism remains unknown. This dissertation examines the role of Na+/Ca2+ exchangers in the invertebrate model organism Caenorhabditis elegans . There are ten identified Na+/Ca2+ exchanger genes in C. elegans (labeled ncx-1 to ncx-10). Data presented here is the first comprehensive description of their genetics and function in C. elegans. The expression pattern of all 10 Na+/Ca2+ exchanger genes is described and their phylogeny is examined comparatively across humans and flies. Analysis of ncx-2 and ncx-8 mutants shows important roles for Na+/Ca2+ exchanger genes in egg-laying, lipid storage and longevity, suggesting a role in diverse biological functions for Na+/Ca2+ exchangers in C. elegans. The function of an NCLX type Na+/Ca 2+ exchanger NCX-9 is also detailed comprehensively. Analysis of ncx-9 mutants shows that NCX-9 is required for asymmetrical axon guidance choices made by the DD and VD GABAergic motor neuron circuit. Pathway analysis shows that NCX-9 regulates asymmetric circuit patterning through RAC-dependent UNC-6/Netrin signaling and LON-2/Glypican Heparan Sulfate signaling. In vitro analysis of NCX-9 physiology in HEK cells shows that NCX-9 is a mitochondrial Na+/Ca2+ exchanger, similar to NCLX, which is its homolog in humans.
Jain, Vikesh. "A platform independent process data exchange mechanism between Java applications and computer aided manufacturing systems." Ohio : Ohio University, 2003. http://www.ohiolink.edu/etd/view.cgi?ohiou1081784819.
Full textCharuk, Jeffrey H. M. "Studies on the development of sarcoplasmic reticulum Ca2+ transport ad sarcolemma Ca2+ exchange systems in embryonic skeletal muscle cultures." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72823.
Full textHayashi, Hideharu. "Pathogenesis and the role of Ca2+ overload during myocardial ischemia/reperfusion." Nagoya University School of Medicine, 2000. http://hdl.handle.net/2237/5357.
Full textWan, Yiding. "Can Taylor rule fundamentals predict exchange rates?" Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/42380/.
Full textCostantini, Mauro, Cuaresma Jesus Crespo, and Jaroslava Hlouskova. "Can Macroeconomists Get Rich Forecasting Exchange Rates?" WU Vienna University of Economics and Business, 2014. http://epub.wu.ac.at/4181/1/wp176.pdf.
Full textSeries: Department of Economics Working Paper Series
Chacon, Aguilar Ana Gloria. "Oil prices and the CAD / USD exchange rate." Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/30231/30231.pdf.
Full textThis thesis studies the relationship between oil and energy prices with the CAD/USD exchange rate using an error correction model closely linked with the Bank of Canada’s exchange rate equation. A structural break occurs in the relationship between oil and energy prices and the CAD/USD exchange rate when this latter is at parity. Accordingly, an error correction model is employed to estimate the CAD/USD exchange rate by incorporating the effect of parity versus non-parity in the forecasting equation. Moreover, the sensitivity of the exchange rate equation shifts in the presence of parity versus the absence of parity. More precisely, when parity occurs, the CAD/USD exchange rate responds less to changes in oil and energy prices.
Evans, Robert J. "What happens next? : can economic forecasters foretell the future?" Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338378.
Full textQian, Jingjing. "A Step Implementation For Product Structure Data Exchange." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76684.
Full textNebaneh, Nixon, and Shella Ndobe. "An Analysis of Exchange Rate Variability and Stock Returns : A Swedish Perspective." Thesis, Umeå universitet, Handelshögskolan vid Umeå universitet, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-38390.
Full textThell, Mats. "Utvärdering av kalenderöverföringsstandarden CAP." Thesis, University of Skövde, Department of Computer Science, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-787.
Full textVi lever i ett stressigt samhälle där allt skall fungera och tiden är emot oss för det mesta. Ifall det gick att schemalägga alla händelser som skall och borde göras i ett gemensamt kalendersystem så skulle det förenkla situationen för många personer, som skall träffas eller andra händelser som kan uppstå. I detta arbete undersöks det ifall en ny öppen standard för kalenderöverföringar skulle fungera, samt om den är tillräckligt bra för att användas, eller om den skall undvikas. Inom arbetet implementeras en prototyp som baseras på denna kalenderöverföringsstandard. Den prototyp som framtogs, tillhandahåller de grundläggande funktionerna i CAP, jämförs med Microsoft Exchange. Slutsatserna av arbetet är att CAP är bra, enkelt och smidigt men protokollet är dock ej klart för att användas som en färdigutvecklad produkt.
Antonakakis, Nikolaos, and Julia Darby. "Forecasting volatility in developing countries' nominal exchange returns." Routledge, 2013. http://dx.doi.org/10.1080/09603107.2013.844323.
Full textPopova, Maria. "Characterization of the interaction between NA⁺/H⁺ exchanger isoform 7 (NHE7) and calmodulin (CaM)." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24209.
Full textHöijer, Mattias, Martin Lejdelin, and Patrik Lindén. "Price Drift on the Stockholm Stock Exchange." Thesis, Jönköping University, Jönköping International Business School, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-635.
Full textThis paper examines whether the phenomena of price drift around quarterly earnings re-leases exist among firms listed on the large cap. list at the Stockholm Stock Exchange for a time period ranging from the first quarter of 2003 to the second quarter of 2006. It fur-thermore examines the ability of the variables forecast error, relative to analyst’s estimates, and firms’ size to explain the variation in price drift among firms.
A sample of some 30 firms were drawn in the first three quarters of each year between 2003 and 2005, for the year of 2006 only the fist two quarters were included in the study. For each quarter all firms were classified into three different portfolios on the basis of earnings deviations relative to mean analyst’s estimates (forecast error). The returns for each firm in all portfolios were investigated during 20 days post- and pre quarterly earnings release date, resulting in an event window totaling 41 days. In order to clear out effects from general market movements the Capital Asset Pricing Model, CAPM, was used in which betas were estimated for all firms each quarter.
The findings from this study indicate that price drift, measured by cumulative abnormal re-turn, occur for firms with both negative forecast error as well as positive. For firms with positive error, statistically significant positive price drift was found for both the pre- and post period. As for the firms with earnings below analyst’s mean estimates, negative prean-nouncement drift was statistically supported.
The ability of firms size and forecast error to explain the variation in price drift on a stock level was very weak, R2 measures of below 5% was reported. However, forecast error was a strongly significant independent variable in the context of the regressions run for both pre- and post-announcement drift. The firms below the lower market cap. quartile in the sample show, on average, lower pre-announcement drift than the firms belonging in the largest quartile.
Concerning market efficiency among the large cap. firms the price drift found is an indica-tion of market inefficiency both it terms of the semi strong and the strong form. However, care should be taken before generalizing the results from this study but. Possible misspeci-fication of the equilibrium return model will skew the price drift measurement. Moreover, speculation is not explicitly controlled for in this test. Finally, this study is done within a li-mited time span; hence generalization over time is not possible
Lee, Ryan S. "Effect of the Ca2+ Binding Properties of Troponin C On Skeletal and Cardiac Muscle Force Development." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274968255.
Full textRajab, Khairan. "Knowledge Guided Non-Uniform Rational B-Spline (NURBS) for Supporting Design Intent in Computer Aided Design (CAD) Modeling." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3302.
Full textOtto, E., S. Rubbert, and J. Borrmeister. "Thermodynamics and charge exchange of the new BMW six-cylinder engine." Sage, 2000. https://publish.fid-move.qucosa.de/id/qucosa%3A38437.
Full textJain, Vikesh. "A PLATFORM INDEPENDENT PROCESS DATA-EXCHANGE MECHANISM BETWEEN JAVA APPLICATIONS AND CAM SYSTEMS." Ohio University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1081784819.
Full textOz, Emrah. "Can Relative Yield Curves Predict Exchange Rate Movements? Example From Turkish Financial Market." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612505/index.pdf.
Full textTarandi, Väino. "Neutral intelligent CAD communication : information exchange in construction based upon a minimal schema." Doctoral thesis, KTH, Fastigheter och byggande, 1998. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2657.
Full textQC 20120124
Tarandi, Väino. "Neutral intelligent CAD communication : information exchange in construction based upon a minimal schema /." Stockholm : Tekniska högsk, 1998. http://www.lib.kth.se/abs98/tara0529.html.
Full textLehner, Zachary M. "Determinants of exchange rate hedging an empirical analysis of U.S. small-cap industrial firms." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/459.
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Trapletti, Adrian, Alois Geyer, and Friedrich Leisch. "Cointegration and exchange market efficiency. An analysis of high frequency data." SFB Adaptive Information Systems and Modelling in Economics and Management Science, WU Vienna University of Economics and Business, 1999. http://epub.wu.ac.at/1346/1/document.pdf.
Full textSeries: Working Papers SFB "Adaptive Information Systems and Modelling in Economics and Management Science"
Fallman, David, and Jens Wirf. "FORECASTING FOREIGN EXCHANGE VOLATILITY FOR VALUE AT RISK : CAN REALIZED VOLATILITY OUTPERFORM GARCH PREDICTIONS?" Thesis, Uppsala universitet, Statistiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-146571.
Full textLópez-Ballesteros, Ana, Cecilio Oyonarte, Andrew S. Kowalski, Penélope Serrano-Ortiz, Enrique P. Sánchez-Cañete, M. Rosario Moya, and Francisco Domingo. "Can land degradation drive differences in the C exchange of two similar semiarid ecosystems?" COPERNICUS GESELLSCHAFT MBH, 2018. http://hdl.handle.net/10150/626541.
Full textChweih, Hanan 1990. "Especificidades teciduais e de sexo no transporte de Ca2+ por mitocôndrias isoladas = avaliações em condições que impedem a transição de permeabilidade = Tissue and sex especifities in the Ca2+ handling by isolated mitochondria: evaluations under conditions avoiding the permeability transition." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313112.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Algumas das características das mitocôndrias, incluindo as suas funções de transporte de Ca2+, podem apresentar dimorfismo sexual e especificidades teciduais. No entanto, as mensurações do transporte de Ca2+ em mitocôndrias isoladas estão sujeitas a artefatos secundários a abertura do poro de transição de permeabilidade mitocondrial (PTP) induzido pelo acúmulo excessivo de Ca2+ nesta organela. Neste estudo, o objetivo inicial foi avaliar se a inibição do PTP pela ciclosporina A (CsA) afeta a mensuração de diversas variáveis que descrevem o transporte de Ca2+por mitocôndrias isoladas de fígado de rato. Os resultados obtidos indicam que as concentrações de estado estável do Ca2+ externo a mitocôndria e as taxas deefluxo mitocondrial de Ca2+através de trocadores seletivos foram superestimados em até 4 vezes quando o PTP não foi inibido farmacologicamente pela CsA. O objetivo subsequente foi analisar o transporte de Ca2+ em mitocôndrias isoladas de fígado, de músculo esquelético, de coração e de cérebro de ratos machos e fêmeas sob condições experimentais específicas (i.e. meio de incubação contendo inibidores TPM, substratos energéticos ligados a NAD e níveis relevantes de Ca2+, Mg2+e Na+). Os dados indicaram que a taxa de influxo de Ca2+em mitocôndrias de fígado foi ~4 vezes superior a dos outros tecidos, as quais foram semelhantes entre si. Em contrapartida, as taxas de efluxo de Ca2+ apresentaram uma maior diversidade entre tecidos, especialmente na presença de Na+. Curiosamente, o efluxo de Ca2+na ausência de Na+foi significativamente mais elevado nas mitocôndrias cardíacas (~4nmol/mg/min) em relação às taxas observadas nos outros tecidos, contrariando a concepção de que o efluxo de Ca2+de mitocôndrias de coração é dependente, quase que exclusivamente, de um trocador que requer Na+. A especificidade em relação ao sexo só foi observada em dois índices relacionados a homeostase mitocondrial de Ca2+(i.e. cinética geral normalizada da captação de Ca2+ e a concentração de estado estável do Ca2+ externo a mitocôndria) em mitocôndrias isoladas de coração (mais lentos ou maiores na fêmea) e na respiração estimulada por ADP em mitocôndrias de fígado (~20% maior na fêmea). O presente estudo demonstrou a importância metodológica de se prevenir a abertura do PTP para a análise das propriedades e da variabilidade fisiológica do transporte de Ca2+por mitocôndrias isoladas. Adicionalmente, concluímos que sob as condições experimentais aqui utilizadas, o efluxo de Ca2+ mitocondrial apresenta grandes especificidades teciduais e que alguns achados desafiam conceitos estabelecidos em estudos anteriores sob condições arguivelmente menos controladas
Abstract: The characteristics of mitochondria, including their Ca2+ transport functions, may exhibit tissue specificity and sex dimorphism. Because the measurements of the Ca2+ handling by isolated mitochondria may be biased by dysfunction secondary to Ca2+-induced mitochondrial permeability transition (MPT) pore opening, this study evaluates the extent to which MPT inhibition by cyclosporine-A affects the measurement of Ca2+ transport in isolated rat liver mitochondria. The results indicate that the steady-state levels of external Ca2+ and the rates of mitochondrial Ca2+ efflux through the selective pathways can be overestimated by up to 4-fold if MPT pore opening is not prevented. Then, we analyzed the Ca2+ transport in isolated mitochondria from the liver, skeletal muscle, heart and brain of male and female rats under incubation conditions containing MPT inhibitors, NAD-linked substrates and relevant levels of free Ca2+, Mg2+ and Na+. Except for the liver mitochondria displaying values4-fold higher, the Ca2+ influx rates were similar among the other tissues. In contrast, the Ca2+ efflux rates exhibited more tissue diversity, especially in the presence of Na+. Interestingly, the Na+-independent Ca2+ efflux was highest in the heart mitochondria (~4 nmol/mg/min), thus challenging the view that heart mitochondrial Ca2+ efflux relies almost exclusively on a Na+-dependent pathway. Sex specificity was only observed in two kinetic indexes (i.e. the normalized overall kinetics of Ca2+ uptake and the steady-state levels of external Ca2+) of heart mitochondrial Ca2+ homeostasis (slower or higher in female)and in the ADP-stimulated respiration of liver mitochondria (~20% higher in females). The present study shows the methodological importance of preventing MPT when measuring the properties and the physiological variability of the Ca2+ handling by isolated mitochondria. Moreover, we conclude that mitochondrial Ca2+ efflux exhibits great tissue specificity under our conditions, which may challenge some concepts raised in previous studies that employed experimental conditions that are arguably not well controlled
Mestrado
Fisiopatologia Médica
Mestra em Ciências
Bottau, Francesco. "Design and optimization af a race car cooling system." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Find full textMahon, Maureen F. "Parents and teachers in education, can social exchange theory explain the nature of the relationship?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ32175.pdf.
Full textHitzing, Christoffer [Verfasser], Jürgen [Akademischer Betreuer] Wienands, and Lutz [Akademischer Betreuer] Walter. "Vav guanine nucleotide exchange factors control B cell antigen receptor-induced Ca2+-signaling / Christoffer Hitzing. Betreuer: Jürgen Wienands. Gutachter: Jürgen Wienands ; Lutz Walter." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1093193298/34.
Full textLopes, João Henrique 1982. "Biovidros derivados do 45S5 : os efeitos do Nb2O5 ou da modificação da superfície com Ca2+ sobre a estrutura e bioatividade." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250001.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Química
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Resumo: Esta tese está dividida em quatro capítulos. O capítulo I apresenta os fundamentos sobre biomateriais e biovidros. O capítulo II é dedicado a investigar os efeitos da adição de óxido de nióbio (Nb2O5) sobre as propriedades físicas, a estrutura do vidro e a bioatividade de duas séries vítreas derivadas do 45S5 Bioglass® (BG45S5). A composição química do BG45S5 foi modificada pela substituição de 1,3 e 2,6% de P2O5 por Nb2O5 e 1, 2 e 5% do SiO2 pelo Nb2O5, gerando as séries (I) e (II), respectivamente (BGNs). A introdução do Nb2O5 aumenta significativamente a densidade e a estabilidade contra a desvitrificação, como evidenciado pelo parâmetro ?Txg = (Tx - Tg). Os espectros de ressonância magnética nuclear no estado sólido MAS NMR para os núcleos 29Si, 31P e 23Na, espectroscopia Raman e a determinação de algumas propriedades físicas permitiu um entendimento detalhado da estrutura dos vidros BGNs. Para os vidros da série I, o octaedro de NbO6 entra na rede silicato, partilhando os seus vértices com os tetraedros de silício para formar cadeias O-Si-O-Nb-O-Si-O, enquanto que para os vidros da série II, os octaedros NbO6 atuam como agente de reticulação para as cadeias de silicatos. A viabilidade celular e a atividade metabólica foram determinadas utilizando o ensaio de MTT. Os resultados dos estudos in vitro com os vidros BGNs sobre a viabilidade dos osteoblastos e proliferação não mostram diferenças significativas entre BGNs e BG45S5. Os resultados da experimentação in vivo em ratos Wistar sugerem que a presença de Nb2O5 pode efetivamente promover um aumento na bioatividade de BGNs, observado pelo aumento da quantidade formada de osso cortical e trabecular. O capítulo III abrange a investigação da modificação da superfície do biovidro BG45S5 pelo enriquecimento com cálcio, por imersão em banho de sal fundido contendo cálcio (BG45Cas) e o seu efeito sobre a estrutura da superfície, a velocidade de dissolução e também a cinética da formação do fosfato de cálcio. A combinação da microscopia de força atômica e espectroscopia Raman (AFM) permitiu o acompanhamento das mudanças estruturais do BG45S5 submetido a diversos tempos de imersão no banho de sal fundido a 480 °C, enquanto que a fluorescência de raios X (XRF) foi empregada para monitorar a evolução temporal do processo de troca iônica entre Ca2+ e Na+. Os rearranjos estruturais, como resultado da troca iônica, foram sistematicamente investigados no BG45Ca30 pelas espectroscopias FTIR e 29Si e 31P MAS NMR. Os resultados mostram que a quantidade de íons cálcio que entram na estrutura do vidro é maior do que a quantidade de íons sódio que deixa a rede, de modo que, para preservar a eletroneutralidade na rede, ocorrem alterações locais na estrutura que conduzem a uma depolimerização da rede de silicato. A formação da fase de fosfato de cálcio quimicamente equivalente à hidroxiapatita (HA) na superfície do biovidro foi estudada por imersão dos biovidros em HEPES 50,69 mmol L-1 e fluido corpóreo simulado (SBF) durante 2 dias. A camada de apatita formada foi caracterizada pela espectroscopia 31P MAS NMR. A cinética de crescimento da camada de apatita sobre a superfície do BG45Ca30 sugere que a modificação da superfície do vidro não só promove uma redução no tempo para a formação de HA, mas também a formação de hidroxiapatita com maior grau de cristalinidade. Finalmente, o capítulo IV descreve as nossas contribuições, observações finais e sugestões para futuros trabalhos
Abstract: This thesis is divided into four chapters. Chapter I presents background information on the biomaterial and bioglasses. Chapter II is devoted to investigate the effects of adding niobium oxide (Nb2O5) on the physical properties, glass structure and bioactivity of two glasses series derived from the 45S5 Bioglass® (BG45S5). The chemical composition of BG45S5 was modified by replacing 1.3 and 2.6% of P2O5 with Nb2O5 and 1, 2.5, and 5% of SiO2 with Nb2O5, generating series (I) and (II), respectively (BGNs). Adding Nb2O5 significantly increases the density and the stability against devitrification as indicated by ?Txg = (Tx - Tg). The multinuclear 29Si, 31P, and 23Na solid-state MAS NMR spectra of the glasses, Raman spectroscopy, and the determination of some physical properties have generated insight into the structure of the glasses. For the series I glasses, the octahedral niobium take part in glasses network, sharing its corners with silicon tetrahedra forming O-Si-O-Nb-O-Si-O chains, whereas for the series II, NbO6 octahedra act as crosslinker for the silicates chains. Cell viability and metabolic activity were determined using the MTT assay. We investigated the in vitro effect of BGNs glasses on osteoblast viability and proliferation. No significant differences were found between BGNs and BG45S5. Furthermore, in vivo tests in Wistar rats have suggested that the presence of Nb2O5 might actually promote an increase in bioactivity of BGNs, increasing formation of cortical and cancellous bones. The chapter III covers research related to of the surface modification of BG45S5 bioglass (BG45Cas) and its effect on the surface structure, dissolution rate and calcium phosphate formation. BG45Cas were obtained by ion exchange method by immersion in molten salt bath containing calcium. The combination of Raman spectroscopy and atomic force microscopy (AFM) allowed the monitoring of the structural changes of BG45S5 bioglass submitted to increasing durations of immersion in the molten salt bath at 480 °C, whereas X-ray Fluorescence (XRF) was employed to derive the time evolution of Ca2+-Na+ ion exchange process. Structural rearrangements as a result of Ca2+-Na+ ion exchange have been investigated systematically on 45S5 bioglasses by FTIR and 29Si and 31P MAS NMR spectroscopies. Results show that the insertion of calcium ions in the glass structure is higher than the departure of sodium ions. The electroneutrality of the glass structure is preserved with local alterations, which lead to a higher degree of depolymerization of the silicate network. The formation of calcium phosphate layer chemically equivalent to hydroxyapatite (HA) on the bioglass surface was evaluated by immersing the bioglasses in the HEPES 50,69 mmol L-1 and simulated body fluid (SBF) for up to 2 days. This apatite layer was characterized by 31P MAS NMR spectroscopy. The growth kinetics of the apatite layer on the surface of the bioglasses demonstrated that modification of the glass surface (BG45Ca30) cause not only a reduction in time of the formation of HA, but also induced hydroxyapatite phase formation with a higher degree of crystallinity. Finally, chapter IV describes our contributions, final remarks and suggests some ideas for future works
Doutorado
Físico-Química
Doutor em Ciências
Sameh, Ebong F. "Sorption of Ni and Eu to granitic rocks and minerals." Thesis, Loughborough University, 2011. https://dspace.lboro.ac.uk/2134/9324.
Full textHammarlund, Pär. "Simulation and Analyis of a Continuous Variable Cam Phasing Internal Combustion Engine." Thesis, Linköping University, Department of Electrical Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12170.
Full textThe development of fuel efficient internal combustion engines (ICE)have resulted in a variety of different solutions. One of those are the variable valve timing and an implemenation of such is the Continuous Variable Cam Phasing (CVCP). This thesis have used a simulation package, psPack, for the simulation of the gas exchange process for an ICE with CVCP. The purpose of the simulations was to investigate what kind of design parameters, e.g. the length of an intake pipe or the duration of combustion, that were significant for the gas exchange process with the alternation of intake pressure, engine speed and valve setting. The parameters that showed a vast impact were those who affected the amount of residual gas and the temperature of the air charge. Furthermore a validation was made between simulation data acquired from psPack and measured data provided in Heywood (1988). The validation showed that for the general behaviour the simulation results from psPack corresponded well to the measured data.
KUNDA, SAKETH RAM. "Methods to Reuse CAD Data in Tessellated Models for Efficient Visual Configurations : An Investigation for Tacton Systems AB." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-281748.
Full textDataförluster har alltid varit en följd av att dela 3D-modeller mellan olika CAD-system. I forskning har nya metoder utvecklats och implementerats för att minimera dataförlusten i CAD och andra program, som t.ex. visuella 3D-grafikapplikationer (3DS Max, Blender etc.). Denna rapport är resultatet av en studie kring CAD-dataförluster när man överför modeller mellan ett CAD-program och ett visualiseringsprogram. Studien har utförts vid Tacton Systems AB, som tillhandahåller produktkonfigureringslösningar både i CAD-program och i visuella miljöer och därför har studien haft fokus på att återanvända eller återskapa CAD-data i visualiseringsprogramvaror. Forskningsfrågorna är inriktade på att hitta orsaker till dataförlusterna och möjliga lösningar för företaget. Eftersom detta är ett högspecialiserat ämne krävde arbetet insatser från olika perspektiv och kunskapsinhämtning från människor också utanför företaget, vilket visar på betydelsen av öppen innovation i teknikorienterade företag. Tio olika idéer togs fram och utvecklades till koncept för att lösa problemet med dataförluster. Alla koncept har analyserats och utvärderats för att bedöma deras funktionalitet och genomförbarhet, för att implementera dem inom företagets arbetsflöde. Utvärderingarna resulterade i sex olika koncept som skulle kunna lösa problemet. Dessa koncept har diskuterats och verifierats med olika personer inom och utanför företaget. Resultatet visar styrkor och svagheter i vart och ett av dessa koncept och ger tydliga rekommendationer till företaget om nästa steg.
Hagba, Dorbor M. "Can market volume help in predicting share market volatility." Thesis, Stellenbosch : University of Stellenbosch, 2007. http://hdl.handle.net/10019.1/15043.
Full textENGLISH ABSTRACT: This paper explores a number of statistical models for predicting the daily stock return volatility of an aggregate of all stocks traded on the Johannesburg Stock Exchange (JSE). The study is largely inspired by the work of Chris Brooks (1998). The volume of shares traded might be as important as the change in a market index since substantial price increases and decreases are often accompanied by heavy trading activity. An application of linear and non-linear Granger causality tests highlights evidence of bidirectional causality, although the relationship is stronger from volatility to volume than from volume to volatility. The out-of-sample forecasting performance of various linear and non-linear models of volatility are evaluated and compared. The models are also augmented by the addition of a measure of lagged volume to form more general ex-ante forecasting models. The results indicate that augmenting models of volatility with measures of lagged volume leads only to fairly small improvements in forecasting performance. The report also shows that the Johannesburg Stock Exchange is vulnerable to financial turmoil in other major markets.
AFRIKAANSE OPSOMMING: Hierdie navorsingsverslag verken 'n aantal statistiese modelle vir die vooruitskatting van die daaglikse onbestendigheid in aandeleopbrengste van die totaal van alle aandele wat op die Johannesburgse Aandelebeurs (JSE) verhandel word. Hierdie studie is grotendeels geinspireer deur die werk van Chris Brooks (1998). Die volume aandele wat verhandel word, kan net so belangrik wees soos die verandering in 'n markindeks omdat beduidende prysverhogings en -verlagings dikwels met swaar verhandelingsaktiwiteite gepaard gaan. 'n Toepassing van liniere en nie-liniere Grangeroorsaaklikheidstoetse lewer bewys van tweerigting-oorsaaklikheid, hoewel daar 'n sterker verband van onbestendigheid na volume is, as van volume na onbestendigheid. Die buite-steekproef vooruitskattingsprestasie van verskeie liniere en nie-liniere modelle van onbestendigheid word geevalueer en vergelyk. Die modelle word aangevul deur die byvoeging van gesloerde volumes om meer algemene vooruitskattingsmodelle te vorm. Die resultate dui daarop dat aangevulde modelle van onbestendigheid met sloerings in volume slegs tot betreklik klein verbeteringe in vooruitskattingsprestasie lei. Die resultate dui daarop dat die Johannesburgse Aandelebeurs kwesbaar is vir finansiele turbulensie in ander belangrike markte.
Andreeva, Marina. "Etude du colmatage des membranes échangeuses d'ions lors de l'électrodialyse de solutions de sels de Ca2+ et Mg2+ : influence des propriétés de surface." Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC1018/document.
Full textScaling on the surface and in the bulk of ion-exchange membranes is a considerable locker for electrodialysis. The scale reduces the effective surface area of the membrane and leads to additional resistance to the mass transfer and solution flow.Three cation-exchange membranes are used in this study: a heterogeneous commercial MK-40 membrane and two of its modifications. The MK-40/Nafion membrane is obtained by mechanical coating the MK-40 membrane surface with a homogeneous ion-conductive Nafion® film. Modification of the MK-40/PANI membrane is carried out by polyaniline synthesis on the membrane surface. The solutions used in the study are 0.02 and 0.04 mol/L CaCl2 and MgCl2 solutions, as well as the solution, imitating the mineral composition of milk, concentrated 3 times. The visualization of the membrane surface is made using optical and scanning electron microscopy. The elemental analysis of the scale on the membrane surface is made by X-ray analysis. The hydrophobic-hydrophilic balance of the membrane surface is estimated by the contact angle measurements. To characterize the cation transport through and the water splitting rate, chronopotentiometry and voltammetry methods are used, pH measurement of the diluate solution is conducted at the same time.It is shown that the relatively high hydrophobicity of the membrane surface, its electrical and geometric heterogeneity, create conditions for the development of electroconvection. The electroconvection intensity in the case of MK-40/Nafion is significantly higher, and in the case of MK-40/PANI is lower in comparison with that of the unmodified membrane. Electroconvection vortexes cause the mixing of the solution at the membrane surface in a 10 µm thick layer. This effect significantly increases mass transfer in intensive current modes and prevents or reduces the scaling process, as well as reduces the water splitting rate at the membrane surface. The rate of electroconvection essentially depends on the counterion hydration degree, it increases with increasing the counterion Stokes radius. The rate of the scale formation on the membrane surface is determined by the slope of the chronopotentiogramme. The formation of Mg(OH)2, Ca(OH)2 and CaCO3 scales is observed. It is experimentally established that the scaling rate on the surface of MK-40/Nafion is smaller, and on the surface of the MK-40/PANI is larger in comparison with the MK-40 membrane. The scaling rate is significantly reduced when the pulsed electric current mode is applied. Such mode allows the reduction of the potential drop more than twice and achievement of a quasi steady-state because an unstable periodically crumbling scale occurs
Antonakakis, Nikolaos. "Exchange Return Co-movements and Volatility Spillovers Before and After the Introduction of Euro." Elsevier, 2012. http://dx.doi.org/10.1016/j.intfin.2012.05.009.
Full textTang, Alex Yee Yuk. "Can stock visibility or neglected-firm effect help explain the outperformance of HK-listed mainland companies?" HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/572.
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