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Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

SZEIMIES, R., and M. LANDTHALER. "C070 Photodynamic therapy." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S73. http://dx.doi.org/10.1016/s0926-9959(97)89142-8.

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2

HOLZLE, E. "C078 Photopatch testing." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S75. http://dx.doi.org/10.1016/s0926-9959(97)89152-0.

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3

ROELANDTS, R. "C077 Investigation of photodermatoses." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S75. http://dx.doi.org/10.1016/s0926-9959(97)89154-4.

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4

DELEO, V. "C075 Drug-induced photosensitivity." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S74. http://dx.doi.org/10.1016/s0926-9959(97)90098-2.

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5

BEANI, J. "C076 Photoprovocation of idiopathic photodermatoses." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S74—S75. http://dx.doi.org/10.1016/s0926-9959(97)89150-7.

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6

WULF, H. "C079 Assessment of skin type." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S75. http://dx.doi.org/10.1016/s0926-9959(97)89151-9.

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7

KRUTMANN, J. "C073 Indications for UVA 1 phototherapy." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S74. http://dx.doi.org/10.1016/s0926-9959(97)89146-5.

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8

THOMAS, P. "C072 PUVA, how to do it safely?" Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S74. http://dx.doi.org/10.1016/s0926-9959(97)89148-9.

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9

Rodrigues, Ayane Araújo, Tereza Cristina de Carvalho Souza Garcês, André dos Santos Carvalho, Maria Isabel de Vasconcelos Mavignier Neta, Even Herlany Pereira Alves, Thayaná Ribeiro Silva Fernandes, Jacks Renan Neves Fernandes, et al. "Scientific and technological prospection of Pilocarpus microphyllus and epiisopilothurin related to their anti-inflammatory activity in wound treatment." International Journal of Advanced Engineering Research and Science 9, no. 10 (2022): 346–64. http://dx.doi.org/10.22161/ijaers.910.39.

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Wounds are a serious public health problem and tissue healing is a complex process that requires clinical intervention. Thus, the use of biomolecules, mainly extracted from plants, presents itself as an alternative that facilitates the innate mechanisms of tissue repair. Among the different species, it is possible to highlight the Pilocarpus microphyllus, commonly known as jaborandi, which has the imidazolic alkaloid epiisopiloturin (EPI) which has emerged in research due to its anthelmintic, anti-inflammatory and antinociceptive action. Therefore, this article aims to carry out a scientific and technological prospection of P. microphyllus and EPI focused on the treatment of wounds on publication sites and articles and national and international patents deposits. For this, a survey was carried out in the following databases: Scientific Electronic Library Online (SciELO), PubMed and Web of ScienceTM for articles and the National Institute of Industrial Property of Brazil (INPI), Latin American Patent Bank (LATIPAT), European Patent Office (EPO), World Intellectual Property Organization (WIPO) and United States Patent and Trademark Office (USPTO) for patents. The search was carried out from October to November 2021, the following descriptors were used: “Pilocarpus microphyllus”, “epiisopilloturin”, “anti-inflammatory”, “in silico” and “wounds” according to the Descriptors in Sciences of Health (DeCs), as well as combinations were performed using the Boolean operator “and”. From the articles it was possible to observe that there is no published study with the use of P. microphyllus or EPI for the treatment of wounds, however they reinforce its anti-inflammatory, antinociceptive and anthelmintic activity. In addition, conducting research in silico has emerged in recent years, expanding the field of research. In patent searches for “Pilocarpus microphyllus”, the classification that registered the highest number of deposits in technological prospecting was CIP A61K, with 68.6% frequency, followed by A01N (6.9%), C07D (5.8%) , A01H (3.4%), C12N (3.4%), A61P (2.3%), A23G (2.3%), C12P (2.3%), C07K (1.1%), A23L (1.1%), A61L (1.1%), A01P (1.1%), respectively. It is noteworthy that the largest number of patents are filed in section A (human needs) and section C (chemistry and metallurgy) of the CIP, totaling 75 and 11 records, respectively. Therefore, the use of P. mycrophyllus and EPI in the development of drugs to be used in the treatment of wounds is a promising scenario for further studies due to their biological activities, which are already well described in the scientific literature.

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10

VANDEKERKHOF, P. "C074 Photobiology; Increasing the efficacy by using combinations." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S74. http://dx.doi.org/10.1016/s0926-9959(97)89149-0.

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11

Yano, Y., N. Takada, A. Saito, D. Anchalee, and A. Kawai. "C07 Vectors of Japanese Babesia microti." Medical Entomology and Zoology 54, supplement (2003): 46. http://dx.doi.org/10.7601/mez.54.46_1.

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12

GOMES, M. "C077 ?Siesta? interferes on daytime ambulatory blood pressure monitoring." American Journal of Hypertension 11, no. 4 (April 1998): 67A. http://dx.doi.org/10.1016/s0895-7061(97)90952-3.

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13

Zhao, Houyu. "Smooth Solutions of a Class of Iterative Functional Differential Equations." Abstract and Applied Analysis 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/954352.

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By Faà di Bruno’s formula, using the fixed-point theorems of Schauder and Banach, we study the existence and uniqueness of smooth solutions of an iterative functional differential equationx′(t)=1/(c0x[0](t)+c1x[1](t)+⋯+cmx[m](t)).

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14

KAINO, Go, Toshinobu TAKEI, and Takashi TSUBOUCHI. "2A1-C07 3D dynamics simulation for bicycle." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2007 (2007): _2A1—C07_1—_2A1—C07_4. http://dx.doi.org/10.1299/jsmermd.2007._2a1-c07_1.

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15

TAKAO, Kei, and Tetsushi BIWA. "C07 Multistage Thermoacoustic Stirling Engine Electric Generator." Proceedings of the Symposium on Stirlling Cycle 2009.12 (2009): 107–8. http://dx.doi.org/10.1299/jsmessc.2009.12.107.

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16

FERGUSON, J. "C071 TL-01: A comparison with conventional broadband UVB/PUVA." Journal of the European Academy of Dermatology and Venereology 9 (September 1997): S74. http://dx.doi.org/10.1016/s0926-9959(97)89147-7.

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17

Necula, V., and M. Cosgarea. "C077 Predictive factors and communication outcomes in Romanian implanted patients." International Journal of Pediatric Otorhinolaryngology 75 (May 2011): 47. http://dx.doi.org/10.1016/s0165-5876(11)70245-2.

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18

Mlynski, R., A. Radeloff, J. Mueller, R. Hagen, and W. Shehata-Dieler. "C078 Benefit of cochlear implantation in children with auditory neuropathy." International Journal of Pediatric Otorhinolaryngology 75 (May 2011): 47. http://dx.doi.org/10.1016/s0165-5876(11)70246-4.

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19

Carlberg, Ulf. "Review: Rearing and Studying Stick and Leaf-Insects." Entomologica Fennica 4, no. 3 (September 1, 1993): 194. http://dx.doi.org/10.33338/ef.83769.

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Brock, P. D. 1992: Rearing and Studying Stick and Leaf-Insects. The Amateur Entomologists' Society, Handbook no. 22. 79 pp., 37 figs. and 7 black-and-white plates, 1 table. Size 14.5 x 21.0 em. -Can be obtained from: AES Publications, The Hawthorns, Prating Road, Great Bromley, Colcester C07 7JN, England. ISBN 0-900054-54-9. Price GBP 5.00.

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20

Perepa, L. S., and G. S. Patil. "C070 Voice characteristics of children with cochlear implant and hearing aid." International Journal of Pediatric Otorhinolaryngology 75 (May 2011): 46. http://dx.doi.org/10.1016/s0165-5876(11)70238-5.

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21

Franklin, R., and J. Mason. "Colloquium C07: The cell biology of myelin repair." Journal of Neurochemistry 94 (June 2005): 62–63. http://dx.doi.org/10.1111/j.1474-1644.2005.03229_7.x.

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22

Okon, K., K. Kaczmarczyk, A. Strzepek, M. Bialas, G. Dyduch, T. Gołąbek, T. Szopinski, and P. Chlosta. "C07: Selected features of ERG-positive prostatic cancer." European Urology Supplements 13, no. 6 (November 2014): e1210. http://dx.doi.org/10.1016/s1569-9056(14)61411-1.

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23

Fenner, H. "Differentielle C0X-2/C0X-1-Hemmung und Nutzen-Risiko-Bewertung von nicht-steroidalen Antirheumatika (NSAR): Neue Antworten auf alte Fragen?" Aktuelle Rheumatologie 23, no. 02 (March 1998): 29–34. http://dx.doi.org/10.1055/s-2008-1043577.

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24

Fenner, H. "Differentielle C0X-2/C0X-1-Hemmung und Nutzen-Risiko-Bewertung von nicht-steroidalen Antirheumatika (NSAR): Neue Antworten auf alte Fragen?" Aktuelle Rheumatologie 23, no. 03 (May 1998): 83. http://dx.doi.org/10.1055/s-2008-1043587.

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25

GOMES, M. "C076 Office vs home blood pressure monitoring and left ventricular mass index." American Journal of Hypertension 11, no. 4 (April 1998): 66A. http://dx.doi.org/10.1016/s0895-7061(97)90951-1.

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26

YAMASAKI, F. "C078 Effect of race on blood pressure (BP) change in experimental stress." American Journal of Hypertension 11, no. 4 (April 1998): 67A. http://dx.doi.org/10.1016/s0895-7061(97)90953-5.

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27

Coimbra, B., L. M. T. Jesus, and P. Sá Couto. "C074 Vowel acoustics in normal and hearing impaired children with cochlear implant." International Journal of Pediatric Otorhinolaryngology 75 (May 2011): 46. http://dx.doi.org/10.1016/s0165-5876(11)70242-7.

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28

Martinez, Marion, Marta Hergueta, Pilar Ximénez de Embún, Ana Dueso, David Torrents, Teresa Macarulla, Javier Muñoz, Héctor Peinado, and María Abad. "Abstract C074: Mining the secreted microproteome for novel regulators of PDAC progression." Cancer Research 82, no. 22_Supplement (November 15, 2022): C074. http://dx.doi.org/10.1158/1538-7445.panca22-c074.

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Abstract Recent work has unveiled a hidden microproteome composed by thousands of small proteins named microproteins: they are functional short proteins coded by genomic regions previously considered non-coding, and which had been completely ignored, mainly due to their small size (<100 aminoacids). To date, only a small part of the thousands of microproteins present in our cells have been characterized, and they are key players in fundamental processes such as DNA repair, mRNA splicing or cell metabolism. In cancer, they have been shown to regulate most tumor hallmarks, and present a huge potential for the clinic as diagnostic and prognostic biomarkers as well as therapeutic targets. Interestingly, their small size makes them ideal candidates to be shed in tumor-derived exosomes. PDAC-shed exosomes have been shown to prepare the pre-metastatic niche in the liver, and their presence in the bloodstream can be used as a surrogate marker of metastasis. Herein, we have mined the PDAC exosome-secreted microproteome for novel regulators of tumor progression and metastasis. Using proteogenomics in PDAC patient-derived explants, we have identified 439 microproteins secreted in exosomes by pancreatic tumors. We have selected a set of top microprotein candidates for further characterization by in silico analyses (e.g. phylogenetic conservation, predicted protein stability and localisation, mRNA expression in PDAC, etc). We have confirmed their exosome secretion in PDAC cell lines, and preliminary characterisation of these top candidates has shown that they extrinsically promote PDAC cell growth and invasion in vitro. Together, this work advances our knowledge on the underexplored field of secreted microproteins and provides pioneering evidence of their role in tumor cell communication in PDAC. It may further be a source of novel therapeutic targets and PDAC biomarkers for liquid biopsy in the clinic. Citation Format: Marion Martinez, Marta Hergueta, Pilar Ximénez de Embún, Ana Dueso, David Torrents, Teresa Macarulla, Javier Muñoz, Héctor Peinado, María Abad. Mining the secreted microproteome for novel regulators of PDAC progression [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr C074.

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29

HAYASHIBARA, Yasuo, Hideaki MINAKATA, Yohei SEIKE, Katsuhiro ICHIZAWA, Shinsuke OGURA, Kiyoshi IRIE, Hajime SAKAMOTO, et al. "1P1-C07 Development of Soccer Robot System "CIT Brains"." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2009 (2009): _1P1—C07_1—_1P1—C07_3. http://dx.doi.org/10.1299/jsmermd.2009._1p1-c07_1.

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30

TORII, Kurato, Takehiro ISHIHARA, and Takeo OMICHI. "1P2-C07 Energy simulator of ICELG(Eco Green Mechatronics)." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2014 (2014): _1P2—C07_1—_1P2—C07_3. http://dx.doi.org/10.1299/jsmermd.2014._1p2-c07_1.

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31

HANAMURA, Takeshi, Kojiro HANAMURA, and Junya TATSUNO. "2P1-C07 Development of Grafting Robot with High Efficiency." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2015 (2015): _2P1—C07_1—_2P1—C07_2. http://dx.doi.org/10.1299/jsmermd.2015._2p1-c07_1.

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32

Miras-Portugal, M. T., M. D. Fideu, R. P. Sen, and E. G. Delicado. "C07 Short and long term regulation of adenosine transport." Nutrition Clinique et Métabolisme 6, no. 4 (January 1992): 242. http://dx.doi.org/10.1016/s0985-0562(05)80382-6.

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33

Delgado-Cruzata, Lissette, Flavia Carvalho, Diego Gomes, Tatiana Simão, Jennifer Vieira, Rachele Grazzioti, and Sheila Coelho. "Abstract C073: Racial disparities in triple negative breast cancer in urban Brazilian women." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): C073. http://dx.doi.org/10.1158/1538-7755.disp22-c073.

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Abstract Breast cancer (BC) is the main cause of cancer-related death for women worldwide. While the incidence of disease is still higher in high income countries, lower and middle income countries have a proportionally higher mortality burden and account for almost half the deaths due to the disease globally. In Brazil, BC is the most common cancer in women, with mortality rates that almost equate those in the US. BC mortality has also been increasing steadily and most women are diagnosed with late stage disease greatly lowering their chances of survival. Data suggests that Black and Brown women suffer from higher excess disease mortality even when extent of disease, year of diagnosis, age and socioeconomic status are considered, highlighting a clear racial BC disparity. Less is known about the distribution of aggressive BC subtypes such as triple negative breast cancer (TNBC) in the Brazilian population in relation to race. Data suggests that TNBC is more common in the northeast of the country where the Afro-Brazilian population is larger. To expand our knowledge, we explore the presence of TNBC among women of different races diagnosed with BC and also its potential association with other variables. We conducted analysis on women that attended the Instituto Nacional do Câncer Hospital in Rio de Janeiro between the years 2016 and 2017, for which more complete data was available. We extracted subtype information from their pathology reports and used the Registros Hospitalares de Câncer (RHC) database to collect data on demographic/lifestyle factors such as age, race, education, alcohol and tobacco use, and disease stage at time of diagnosis. We conducted our analysis on 243 women with full records on all variables selected using multivariate logistic regression analysis. We found a significant difference in the proportion of TNBC by race, 41.2% of TNBC were found in Black women, while only 23.5% and 35.3% of the TNBC tumors were found in Brown and White women, respectively (p=0.028). We also found that TNBC was diagnosed in this cohort at a later stage than other subtypes. TNBC is diagnosed at a later clinical (III and IV) and pathological stage (3), while other subtypes tend to be diagnosed earlier at stages I/II or 1/2a. 47% of women with TNBC are diagnosed with stage 3a and 3b, while only 13.4% of women with other cancer are diagnosed at these stages (p=0.024). Similarly, of all diagnoses made at stage III and IV, 47.1% were TNBC and 14.7% were of other tumors (p=0.001). When adjusted for age and clinical stage, being Black was still significantly associated with being diagnosed with TNBC (β=1.57, 95% Confidence Interval 1.67-13.75, p=0.004). Interestingly, similar associations between race and TNBC diagnosis were not observed in women that self identified as Brown. These preliminary results add to our knowledge of the importance of considering subtype when analyzing race/ethnicity in association to BC outcomes. In future work, we will expand our analysis to other clinical variables and use larger samples to better understand these associations. Citation Format: Lissette Delgado-Cruzata, Flavia Carvalho, Diego Gomes, Tatiana Simão, Jennifer Vieira, Rachele Grazzioti, Sheila Coelho. Racial disparities in triple negative breast cancer in urban Brazilian women [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C073.

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34

Phinney, Natalie Z., Xianming Huang, and Rolf Brekken. "Abstract C079: Aberrantly exposed phosphatidylserine as a drug delivery target in pancreatic cancer." Cancer Research 82, no. 22_Supplement (November 15, 2022): C079. http://dx.doi.org/10.1158/1538-7445.panca22-c079.

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Abstract Pancreatic ductal adenocarcinoma (PDA) has risen to become the 3rd leading cause of cancer related deaths in the United States with a 5-year survival rate of 11% and a median survival of just 4-6 months. PDA is notoriously chemoresistant and has shown little to no sensitivity to the current immune checkpoint blockade therapy. A novel marker for the tumor microenvironment that has emerged is phosphatidylserine, initially characterized as a selective marker of tumor vasculature. Phosphatidylserine (PS) is a phospholipid exposed on the outer leaflet of the plasma membrane of tumor associated endothelial cells, apoptotic tumor cells, and some viable tumor cells, where it functions to suppress the immune response. Exposed PS drives immunosuppression by binding to PS receptors expressed on tumor-infiltrating macrophages and dendritic cells. To this point, PS has been targeted with antibodies, such as Bavituximab, that have shown excellent specificity for tumor vasculature and an immune stimulatory environment evidence by polarization of macrophages to a pro-inflammatory M1-like phenotype, a reduction in myeloid-derived suppressor cells, enhanced maturation of dendritic cells and increased primed T cell activity. We have advanced this concept by developing the next generation of PS targeting agent, a fusion protein (betabody) that exploits the PS-binding domain of β2-glycoprotein 1 (β2GP1), an abundant serum protein that binds PS. Betabodies were constructed by fusing domain V of β2GP1 to the Fc of an IgG2a. Betabodies are smaller than full length antibodies (~85 kDa vs 150 kDa), have good affinity for PS (~1 nM) and bind directly to PS. We have demonstrated that betabodies bind specifically to externalized PS through ELISA, ICC and flow cytometry. We established that betabodies localize robustly and specifically to the tumor microenvironment through in vivo localization experiments in tumor-bearing C57Bl/6 mice. Further studies will exploit the specificity of betabodies to deliver novel microtubule-disrupting agents to exposed PS in the microenvironment of PDA. Due to the fact that betabodies are internalized inefficiently, therapeutic payloads will be linked to betabodies via enzyme cleavable linkers. This first-in-class tumor targeting therapeutic has potential to provide efficacy in therapy-resistant pancreatic tumors. Citation Format: Natalie Z. Phinney, Xianming Huang, Rolf Brekken. Aberrantly exposed phosphatidylserine as a drug delivery target in pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr C079.

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35

de Laat, Vincent, Halit Topal, Jonas Dehairs, Xander Spotbeen, Ali Talebi, Frank Vanderhoydonc, Tessa Ostyn, Tania Roskams, Baki Topal, and Johan Swinnen. "Abstract C077: Evidence for a tumoral temperature driven chemoresistance pathway in pancreatic cancer." Cancer Research 82, no. 22_Supplement (November 15, 2022): C077. http://dx.doi.org/10.1158/1538-7445.panca22-c077.

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Abstract Tumor growth is inevitably accompanied by changes in the tumor-microenvironment to which cancer cells have to adapt in order to thrive. Alterations in metabolism and blood perfusion of solid tumors have been suggested to drive a spontaneous increase in tumoral temperature. However, it is currently unknown if this phenomenon affects cancer biology. We found increased temperature in human pancreatic ductal adenocarcinoma (PDAC) tumors. By mimicking this observation in PDAC cell lines, we found that cancer cells adapt to tumoral temperature by altering the cellular lipidome and accordingly evade ferroptosis, a lipid-dependent form of cell death. We found evidence that tumoral temperature-induced ferroptosis evasion depends on p38-MAPK deactivation and ultimately drives resistance to the chemotherapeutic drug gemcitabine. Collectively, our findings suggest a direct role for p38-dependend ferroptosis evasion in gemcitabine resistance, and we identify tumoral temperature as a pathophysiological driver of this process. Our discovery unveils temperature as an unexplored hallmark of the tumor-microenvironment. Citation Format: Vincent de Laat, Halit Topal, Jonas Dehairs, Xander Spotbeen, Ali Talebi, Frank Vanderhoydonc, Tessa Ostyn, Tania Roskams, Baki Topal, Johan Swinnen. Evidence for a tumoral temperature driven chemoresistance pathway in pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr C077.

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36

Bell, Whitney, Nancy Kren, Yan Wang, and Yuliya Pylayeva-Gupta. "Abstract C072: Cytokine modulation can suppress an EMT-like phenotype in pancreatic cancer." Cancer Research 82, no. 22_Supplement (November 15, 2022): C072. http://dx.doi.org/10.1158/1538-7445.panca22-c072.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a 5-year survival rate of only 11% and approximately half of patients present with distant metastasis at the time of diagnosis. PDAC is accompanied by pronounced alterations in stromal responses and immune surveillance programs, which are now recognized as some of the major drivers in PDAC tumor evolution. The role of immune modulators in driving metastatic potential in PDAC is poorly understood. We find that low expression levels of cytokine IL-23 in patients with PDAC correlate with poor differentiation status of these tumors, and thus predict poor outcomes. Consistent with this observation, we have found that a loss of host-derived IL-23 in a mouse model of pancreatic cancer promotes an EMT-like phenotype. The tumor morphology is altered and appears to be less differentiated. Additionally, we see a significant increase in the number of tumor cells expressing Zeb1 and a decrease in E-cadherin expression. We also find an increase in metastatic capacity in the absence of IL-23 in the tumor stroma. Single cell RNA sequencing of tumors injected orthotopically into IL-23 knockout mice reveals clusters of tumor cells with increases in EMT-associated genes such as Zeb1 and Vimentin and concurrent decreases in gastric identity genes. Overall, our findings indicate that IL-23 plays a role in suppressing an EMT-like phenotype in pancreatic cancer with one mechanism being through regulation of gastric lineage genes. Citation Format: Whitney Bell, Nancy Kren, Yan Wang, Yuliya Pylayeva-Gupta. Cytokine modulation can suppress an EMT-like phenotype in pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr C072.

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37

TAKAO, Seishin, Shigeru TADANO, Hiroshi TAGUCHI, and Hiroki SHIRATO. "1P1-C07 Simulation of Radiotherapy for Metastatic Cervical Lymph nodes." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2010 (2010): _1P1—C07_1—_1P1—C07_2. http://dx.doi.org/10.1299/jsmermd.2010._1p1-c07_1.

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38

MAEKAWA, Hitoshi. "1A1-C07 Constraint Relaxation on a Design of Planetary Gears." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2006 (2006): _1A1—C07_1—_1A1—C07_4. http://dx.doi.org/10.1299/jsmermd.2006._1a1-c07_1.

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39

YASUNAKA, Shigen, Kazushi ONDA, Naohiko SUGITA, Keiji TANIMOTO, Kazuo TANOUE, Satoshi IEIRI, Kozo KONISHI, Takanori NAKATSUJI, Makoto HASHIZUME, and Mamoru MITSUISHI. "1P1-C07 Development of a Manipulator for Tele Laparoscopic Surgery." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2008 (2008): _1P1—C07_1—_1P1—C07_2. http://dx.doi.org/10.1299/jsmermd.2008._1p1-c07_1.

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40

KOSHIMIZU, Takao, Daisaku KASAO, Hiromi KUBOTA, Yasuyuki TAKATA, and Takehiro ITO. "C07 Numerical Analysis of Heat Transfer Coefficient in Oscillatory Flows." Proceedings of the Symposium on Stirlling Cycle 2008.11 (2008): 87–88. http://dx.doi.org/10.1299/jsmessc.2008.11.87.

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Setiawan, Ikhsan, Makoto Nohtomi, and Masafumi Katsuta. "C07 Design of Thermoacoustic Prime Mover Driven by Pressurized Steam." Proceedings of the Symposium on Stirlling Cycle 2011.14 (2011): 111–14. http://dx.doi.org/10.1299/jsmessc.2011.14.111.

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Caballo Villar, María Belén, Laura Varela Crespo, and Eusebio Manuel Nájera Martínez. "El ocio de los jóvenes en España. Una aproximación a sus prácticas y barreras." OBETS. Revista de Ciencias Sociales 12, no. 3 (November 13, 2017): 43. http://dx.doi.org/10.14198/obets2017.12.1.11.

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El artículo toma como referencia el proyecto “De los tiempos educativos a los tiempos sociales: la construcción cotidiana de la condición juvenil en una sociedad de redes. Problemáticas y alternativas pedagógico-sociales” (EDU2012-39080-C07). Presenta los resultados referidos a la utilización del tiempo libre derivados de un cuestionario aplicado en el curso 2015-2016 a una muestra de 2694 estudiantes de Educación Secundaria Postobligatoria. Se concluye el predominio de prácticas asociadas a las dimensiones lúdica, cultural y festiva del ocio, siendo residual la dimensión solidaria. Destacan las barreras temporales y el déficit de alfabetización en ocio.

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SOBRINO, J. "C070 Reproducibility of the circadian variability by 24-H ABPM in essential hypertension(EH)." American Journal of Hypertension 11, no. 4 (April 1998): 65A. http://dx.doi.org/10.1016/s0895-7061(97)90945-6.

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UEMURA, K. "C079 Post prandial hypotension in essential hypertensive patients: Evaluation by ambulatory blood pressure monitoring." American Journal of Hypertension 11, no. 4 (April 1998): 67A. http://dx.doi.org/10.1016/s0895-7061(97)90954-7.

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Attebury, Holly B. "Abstract C076: Bacterial dysbiosis and its association with pancreatic cancer progression and poor survival." Cancer Research 82, no. 22_Supplement (November 15, 2022): C076. http://dx.doi.org/10.1158/1538-7445.panca22-c076.

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Abstract Bacterial dysbiosis is emerging as an accomplice to carcinogenesis and is associated with pancreatic cancer progression and poorer survival. We found that gut bacteria can directly access the pancreas, and pancreatic tumors harbor a unique microbiome that differs from that of the healthy pancreas. We have also found that the tumor-associated microbiome regulates pancreatic cancer progression by skewing tumor-infiltrating immune cells towards an immunosuppressive phenotype. However, the exact mechanisms via which bacteria regulate immune cell function is still unknown. Inflammatory signaling by cancer cells and stromal cells in the tumor microenvironment has been shown to effectively regulate immune cell infiltration and differentiation. Our data suggests that pathogenic bacteria in the pancreatic tumor microenvironment can directly engage with pancreatic epithelial cells inducing proliferation and an inflammatory response. Specifically, the dominant Proteobacteria in the pancreatic tumor microenvironment induces the production of many pro-tumorigenic cytokines, such as IL-8 and IL-6, from cancer cells and pancreatic epithelial cells. Furthermore, we have found that pancreatic tumor- associated bacteria skews fibroblast differentiation towards an inflammatory, tumor-promoting phenotype. These findings show that pathogenetic tumor-associated bacteria can modulate the epithelial and stromal compartments in the pancreatic tumor microenvironment, thereby serving as mediators of tumorigenesis. Our results delineate the mechanisms via which microbes interface with the non-immune cell compartment in the tumor microenvironment and provide insight into therapeutic strategies for gut microbial modulation in treating pancreatic cancer. Citation Format: Holly B. Attebury. Bacterial dysbiosis and its association with pancreatic cancer progression and poor survival [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr C076.

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Binglong, Zhu, Su Xiaoxue, Cao Yuqing, and Yan Fengxiang. "Determining parameters of the CSUH constitutive model by genetic algorithm." Japanese Geotechnical Society Special Publication 8, no. 6 (March 14, 2020): 188–93. http://dx.doi.org/10.3208/jgssp.v08.c07.

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Lee, Teresa. "Current Research." Journal of the Canadian Health Libraries Association / Journal de l'Association des bibliothèques de la santé du Canada 28, no. 1 (March 1, 2007): 27. http://dx.doi.org/10.5596/c07-001.

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Lee, Teresa. "News and Notes." Journal of the Canadian Health Libraries Association / Journal de l'Association des bibliothèques de la santé du Canada 28, no. 1 (March 1, 2007): 39. http://dx.doi.org/10.5596/c07-002.

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Gallo Stampino, Victoria. "Improving access to multilingual health information for newcomers to Canada." Journal of the Canadian Health Libraries Association / Journal de l'Association des bibliothèques de la santé du Canada 28, no. 1 (March 1, 2007): 15. http://dx.doi.org/10.5596/c07-003.

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Canada's immigrant and refugee population is a vulnerable group in our health care system with specific information needs. Newcomers to Canada face certain socioeconomic, cultural–linguistic, and systemic barriers to access to health care that government, social agencies, and health care organizations work to overcome. To address some of the communication barriers, many health organizations develop information resources such as online brochures and education handouts. Several organizations offer specifically tailored multilingual publications to meet newcomers' information needs and write them using cross-cultural approaches. However, multilingual health information may be hard to locate and is not readily available through major Canadian consumer Web sites. This article discusses the advantages of sharing multilingual publications online and asks whether a central portal or repository is a possible solution for making publications more widely available across Canada.

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Ganshorn, Heather. "Bloodletting and Miraculous Cures." Journal of the Canadian Health Libraries Association / Journal de l'Association des bibliothèques de la santé du Canada 28, no. 1 (March 1, 2007): 31. http://dx.doi.org/10.5596/c07-004.

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