Relevant bibliographies by topics / C-terminal loop

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'C-terminal loop'

Author: Grafiati
Published: 6 September 2023
Last updated: 31 July 2025

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Journal articles on the topic "C-terminal loop"

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MONLEÓN, Daniel, Vicent ESTEVE, Helena KOVACS, Juan J. CALVETE, and Bernardo CELDA. "Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMR." Biochemical Journal 387, no. 1 (2005): 57–66. http://dx.doi.org/10.1042/bj20041343.

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Echistatin is a potent antagonist of the integrins αvβ3, α5β1 and αIIbβ3. Its full inhibitory activity depends on an RGD (Arg-Gly-Asp) motif expressed at the tip of the integrin-binding loop and on its C-terminal tail. Previous NMR structures of echistatin showed a poorly defined integrin-recognition sequence and an incomplete C-terminal tail, which left the molecular basis of the functional synergy between the RGD loop and the C-terminal region unresolved. We report a high-resolution structure of echistatin and an analysis of its internal motions by off-resonance ROESY (rotating-frame Overhau
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Harouaka, Djamila, and Gail W. Wertz. "Mutations in the C-Terminal Loop of the Nucleocapsid Protein Affect Vesicular Stomatitis Virus RNA Replication and Transcription Differentially." Journal of Virology 83, no. 22 (2009): 11429–39. http://dx.doi.org/10.1128/jvi.00813-09.

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ABSTRACT The 2.9-Å structure of the vesicular stomatitis virus nucleocapsid (N) protein bound to RNA shows the RNA to be tightly sequestered between the two lobes of the N protein. Domain movement of the lobes of the N protein has been postulated to facilitate polymerase access to the RNA template. We investigated the roles of individual amino acid residues in the C-terminal loop, involved in long-range interactions between N protein monomers, in forming functional ribonucleoprotein (RNP) templates. The effects of specific N protein mutations on its expression, interaction with the phosphopro
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Burkhart, Michael D., Paul D'Agostino, Samuel C. Kayman, and Abraham Pinter. "Involvement of the C-Terminal Disulfide-Bonded Loop of Murine Leukemia Virus SU Protein in a Postbinding Step Critical for Viral Entry." Journal of Virology 79, no. 12 (2005): 7868–76. http://dx.doi.org/10.1128/jvi.79.12.7868-7876.2005.

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ABSTRACT A role for the C-terminal domain (CTD) of murine leukemia virus (MuLV) Env protein in viral fusion was indicated by the potent inhibition of MuLV-induced fusion, but not receptor binding, by two rat monoclonal antibodies (MAbs) specific for epitopes in the CTD. Although these two MAbs, 35/56 and 83A25, have very different patterns of reactivity with viral isolates, determinants of both epitopes were mapped to the last C-terminal disulfide-bonded loop of SU (loop 10), and residues in this loop responsible for the different specificities of these MAbs were identified. Both MAbs reacted
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Qiao, Renping, Florian Weissmann, Masaya Yamaguchi, et al. "Mechanism of APC/CCDC20 activation by mitotic phosphorylation." Proceedings of the National Academy of Sciences 113, no. 19 (2016): E2570—E2578. http://dx.doi.org/10.1073/pnas.1604929113.

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Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivator CDC20 (cell division cycle 20). To avoid chromosome missegregation, APC/CCDC20 activation is tightly controlled. CDC20 only associates with APC/C in mitosis when APC/C has become phosphorylated and is further inhibited by a mitotic checkpoint complex until all chromosomes are bioriented on the spindle. APC/C contains 14 different types of subunits, most of which are phosphorylated in mitosis on multiple sites. However, it is unknown which of the
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Ren, Chunguang, Satoshi Nagao, Masaru Yamanaka, et al. "Oligomerization enhancement and two domain swapping mode detection for thermostable cytochrome c552via the elongation of the major hinge loop." Molecular BioSystems 11, no. 12 (2015): 3218–21. http://dx.doi.org/10.1039/c5mb00545k.

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High-order oligomers increased whereas N-terminal domain swapping and C-terminal domain swapping were elucidated by the insertion of Gly residues at the major hinge loop of cytochrome c<sub>552</sub>.
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Bury, Loredana, Emanuela Falcinelli, Haripriya Kuchi Bhotla та ін. "A p.Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD". Blood Advances 6, № 7 (2022): 2236–46. http://dx.doi.org/10.1182/bloodadvances.2021005463.

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Abstract Gain-of-function (GOF) variants in GP1BA cause platelet-type von Willebrand disease (PT-VWD), a rare inherited autosomal dominant bleeding disorder characterized by enhanced platelet GPIbα to von Willebrand factor (VWF) interaction, and thrombocytopenia. To date, only 6 variants causing PT-VWD have been described, 5 in the C-terminal disulfide loop of the VWF-binding domain of GPIbα and 1 in the macroglycopeptide. GOF GP1BA variants generate a high-affinity conformation of the C-terminal disulfide loop with a consequent allosteric conformational change on another region of GPIbα, the
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Takemoto, D. J., L. J. Takemoto, J. Hansen, and D. Morrison. "Regulation of retinal transducin by C-terminal peptides of rhodopsin." Biochemical Journal 232, no. 3 (1985): 669–72. http://dx.doi.org/10.1042/bj2320669.

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Transducin is a multi-subunit guanine-nucleotide-binding protein that mediates signal coupling between rhodopsin and cyclic GMP phosphodiesterase in retinal rod outer segments. Whereas the T alpha subunit of transducin binds guanine nucleotides and is the activator of the phosphodiesterase, the T beta gamma subunit may function to link physically T alpha with photolysed rhodopsin. In order to determine the binding sites of rhodopsin to transducin, we have synthesized eight peptides (Rhod-1 etc.) that correspond to the C-terminal regions of rhodopsin and to several external and one internal loo
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Goch, G., H. Kozłowska, A. Wójtowicz, and A. Bierzyński. "A comparative CD and fluorescence study of a series of model calcium-binding peptides." Acta Biochimica Polonica 46, no. 3 (1999): 673–77. http://dx.doi.org/10.18388/abp.1999_4139.

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Lanthanide-saturated peptides analogous to calcium-binding loops of EF-hand proteins can be used to stabilize the alpha-helical structure of peptide or protein segments attached to their C-termini. To study conformational properties of such loop-containing hybrids it is necessary to produce them in bacteria. In peptides obtained in this way the helix will be destabilized by the negatively charged C-terminal alpha-carboxyl groups. We propose to block them by the homoserine lactone. The results presented in this paper indicate that the presence of the lactone even at the C-terminus of the loop d
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Blodgett, David M., Julie K. De Zutter, Kara B. Levine, Pusha Karim, and Anthony Carruthers. "Structural Basis of GLUT1 Inhibition by Cytoplasmic ATP." Journal of General Physiology 130, no. 2 (2007): 157–68. http://dx.doi.org/10.1085/jgp.200709818.

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Cytoplasmic ATP inhibits human erythrocyte glucose transport protein (GLUT1)–mediated glucose transport in human red blood cells by reducing net glucose transport but not exchange glucose transport (Cloherty, E.K., D.L. Diamond, K.S. Heard, and A. Carruthers. 1996. Biochemistry. 35:13231–13239). We investigated the mechanism of ATP regulation of GLUT1 by identifying GLUT1 domains that undergo significant conformational change upon GLUT1–ATP interaction. ATP (but not GTP) protects GLUT1 against tryptic digestion. Immunoblot analysis indicates that ATP protection extends across multiple GLUT1 do
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Wang, Zhaoxiang, Kangkang Chen, Song Liu, Jianghua Li, and Guocheng Du. "Engineering the C-Terminal Region to Enhance the Thermal Stability of Streptomyces hygroscopicus Transglutaminase." Catalysts 14, no. 10 (2024): 706. http://dx.doi.org/10.3390/catal14100706.

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To enhance the applied value of transglutaminase (TGase), various methods have been employed to improve its catalytic properties. However, most modifications have targeted the N-terminus, while the role of the C-terminus in determining TGase properties has been overlooked. In this study, we focused on enhancing the thermal stability of Streptomyces hygroscopicus TGase by engineering its C-terminal region. Modeling revealed that the C-terminal loop interacts with the N-terminal loop through hydrogen bonds between Trp331 and N-terminal residues (Asp19, Ala20, Tyr21). Removing the last C-terminal
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Dissertations / Theses on the topic "C-terminal loop"

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Guo, Xiangxue. "Biochemical and Bioinformatics Analysis of CVAB C-Terminal Domain." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/3.

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Cytoplasmic membrane proteins CvaB and CvaA and the outer membrane protein TolC form the bacteriocin colicin V (ColV) secretion system in Escherichia coli. CvaB functions as an ATP-binding cassette transporter with nucleotide-binding motifs in the C-terminal domain (CTD). To study the role of CvaB-CTD in the ColV secretion, a truncated construct of this domain was made and over-expressed. Different forms of CvaB-CTD were obtained during purification, and were identified as monomer, dimer, and oligomer on gel filtration. Nucleotide binding was shown critical for the CvaB-CTD dimerization: olig
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Reincke, Momsen [Verfasser]. "Inactivation and anion selectivity of volume-regulated anion channels depend on C-terminal residues of the first extracellular loop / Momsen Reincke." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1140486772/34.

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Lin, Po-Yu, and 林柏宇. "Role of the SWI5 C-terminal loop in SWI5-SFR1c complex interaction with RAD51." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/95275546855885361965.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>104<br>SWI5-SFR1 protein complex (S5S1) has been proven as an accessory factor of homologous recombination repair, which can restore the DNA double strands break (DSB). When DNA double strands break (DSB) happen, RAD51 recombinases (RAD51) as a key protein form a presynaptic filament via binding to a single-stranded DNA. Then, ATP would bind to RAD51 to stabilize the RAD51-DNA complex and induce single-stranded DNA exchange. Due to the hydrolytic activity of RAD51, ATP would be hydrolyzed to ADP and the activity of RAD51-DNA complex will decrease, and S5S1 can p
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Sathyanarayana, Pradeep. "Molecular determinants of self-assembly of the pore forming toxin Cytolysin A." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/5303.

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Pore forming toxins (PFTs) belong to a class of bacterial exotoxins that disrupt the biological membrane barrier by formation of nanopores. These toxins are central to the virulence of pathogens such as S. pneumoniae, V. cholerae, L. monocytogenes and B. anthracis to name a few. Formation of pores lead to the killing of cells due to cellular ion imbalance and efflux of important biomolecules such as ATP, from the cell. Unique to this class of proteins is their ability to exist in bi-stable states i.e., they are produced in soluble forms and upon exposure to membrane, undergo conformation
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Hsu, Po-Hung, and 徐鉑泓. "Use Proximity-dependent biotinylation to identify C-terminal interacting proteins of mouse Cryptochrome 1 and to characterize their roles in the regulation of transcription-translation feedback loop of circadian clock." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107NCHU5107005%22.&searchmode=basic.

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碩士<br>國立中興大學<br>生物化學研究所<br>107<br>CRY is an important transcriptional regulator in the transcription-translation feedback loop of circadian rhythm. In mammalian cells, CRY transcription is activated by the CLOCK::BMAL1 transcription factor, and the production protein CRY can alone or form a heterodimer with another protein PER to repress the transcriptional activty of the circadian rhythm core proteins CLOCK and BMAL1 to achieve the feedback mechanism. CRY is one of a photolyase/cryptochrome family protein. The main difference from other member proteins is the sequence and length of the C-term
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Wang, Chih-Chieh, and 王志傑. "NMR Study of Streptopain: The role of the catalytic and C-terminal Loops in its Inhibitor Binding and Protease Activity." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/46708686670521161731.

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碩士<br>國立成功大學<br>生物化學研究所<br>94<br>Streptopain (streptococcal pyrogenic exotoxin B; SPE B) is an extracellular cysteine protease expressed by the pathogenic bacterium Streptococcus pyogenes. SPE B is initially expressed as a 42-kDa zymogen and subsequently converted to a 28-kDa active protease by autocatalysis or proteolysis. Many reports have shown that SPE B is an important virulence factor in streptococcal infection such as the dissemination, colonalization, invasion of bacteria, and inhibition of wound healing. To understand why SPE B has broad substrate specificity and to design the drugs f
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Baalmann, Elisabeth. "Physiologische und strukturelle Untersuchungen zur Redoxmodulation, Aggregation/Dissoziation und Coenzymspezifität der NAD(P)(H)-Glycerinaldehyd-3-Phosphat Dehydrogenase." Doctoral thesis, 2004. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2004070814.

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Die in dieser Arbeit durchgeführten Untersuchungen dienten dazu, die Eigenschaften und Grundlagen zur Regulation der chloroplastidären NAD(P)(H)-GAPDH im Wechsel zwischen Licht- und Dunkelmetabolismus aufzuklären. Dazu wurden Untersuchungen mit dem System ‘isoliertes Enzym’ und dem System ‘isolierte Chloroplasten’ durchgeführt. Durch die Herstellung proteolysierter NAD(P)(H)-GAPDH und rekombinanter Untereinheiten GapAM, GapBM und GapBMDC, sowie gleichzeitig exprimierter GapAMBM und GapAMBMDC war die Möglichkeit geschaffen, die Funktion der CTE bei der Regulation zu untersuchen. Eigenschaften v
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Book chapters on the topic "C-terminal loop"

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Inglis, Adam S., John F. K. Wilshire, Franca Casagranda, and Robert L. Laslett. "C-terminal Sequencing: A New Look at the Schlack-Kumpf Thiocyanate Degradation Procedure." In Methods in Protein Sequence Analysis. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73834-0_18.

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Littlewood, Trevor D., and Gerard I. Evan. "Introduction." In Helix-Loop-Helix Transcription Factors. Oxford University PressOxford, 1998. http://dx.doi.org/10.1093/oso/9780198502487.003.0001.

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Abstract The transcription of genes within eukaryotic cells is controlled by complex interactions between transcription factors and specific DNA recognition sequences in target genes. These DNA-binding transcription factors fall into a number of groups, each defined by shared sequence and, presumably structural, motifs. One such motif is the helix-loop-helix (HLH), first identified in an immunoglobulin enhancer-binding polypeptide as well as several other proteins known, or suspected, to be transcription factors [741]. The HLH region has also sometimes been referred to as the ‘Myc homology dom
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Maroni, Gustavo. "The Andropin and Cecropins Gene Cluster: Anp, CecAl, CecA2, CecB, CecC." In An Atlas of Drosophila Genes. Oxford University PressNew York, NY, 1993. http://dx.doi.org/10.1093/oso/9780195071160.003.0005.

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Abstract Sequence analysis suggests that each polypeptide may fold into two amphipathic α-helices separated by a four-amino-acid loop (Samakovlis et al. 1991). By analogy to the better-characterized cecropins of the moth Hyalophora cecropia, processing is predicted to include the removal of the signal peptide and of an additional dipeptide at the N-terminus, and cleavage of the terminal Gly plus amidation at the C-terminus. These changes would give rise to mature cecropins 39 amino acids long (Kylsten et al. 1990, see Sequences).
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Littlewood, Trevor D., and Gerard I. Evan. "Structure/function relationships of HLH proteins." In Helix-Loop-Helix Transcription Factors. Oxford University PressOxford, 1998. http://dx.doi.org/10.1093/oso/9780198502487.003.0003.

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Abstract The bHLH proteins bind DNA as dimers and usually recognize short palindromic sequences (CANNTG) such that each protein monomer binds one haif-site. Immediately N-terminal to the HLH or HLHZ dimerization domain is a region of basic amino acids (b) presumed to mediate DNA binding. Sequence specificity is assumed to reside in the combination of the two basic domains in the dimer. Exceptions to this linear arrangement of basic domain and dimerization domain are a number of proteins with no recognizable basic domain such as Extramacrochaetae and Id (Fig. 2). These proteins, which are unabl
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Hellemans, Jan, and Geert R. Mortier. "LEMD3 and Osteopoikilosis, the Buschke–Ollendorff Syndrome and Melorheostosis." In Inborn Errors Of Development. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0038.

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Abstract LEMD3 is an integral protein of the inner nuclear membrane and has a molecular mass of approximately 100 kDa. It is composed of a nucleoplasmic N-terminal domain, a #rst transmembrane segment, a luminal loop, a second transmembrane segment and a nucleoplasmic C-terminal domain (Fig. 38–1) (Lin et al., 2000). LEMD3 was previously known as MAN1. It was initially identi#ed as a nuclear envelope protein recognized by autoantibodies from a patient (MAN refers to the initials of this patient) with an ill-de#ned collagen vascular disease (Paulin-Levasseur et al., 1996). To avoid confusion wi
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Ho, Maurice K. C., and Yung H. Wong. "Adenylyl cyclases and cyclic AMP." In Signal Transduction. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780199637218.003.0009.

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Abstract Adenylyl cyclase (AC; adenylate cyclase or ATP pyrophosphate lyase; E.C. 4.6.1.1) catalyses the formation of cyclic AMP (cAMP), using ATP as substrate. The theoretical topology of all ACs is similar, with both amino- and carboxyl-termini on the cytosolic side, twelve transmembrane domains divided into two groups, and linked with an extended cytosolic loop (1). The catalytic activity and the regulatory elements of AC appear to be concentrated on the cytosolic loop (C1 domain) and the carboxyl-terminal tail (C domain). To date, nine subtypes of mammalian adenylyl cyclases (A Cs) have be
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Tobin, Andrew B., Angela Rae,, and David C. Budd. "G protein-coupled receptor phosphorylation and desensitization." In Signal Transduction. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780199637218.003.0004.

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Abstract Phosphorylation of G protein-coupled receptors (GPCRs) has been linked with receptor desensitization, primarily through work on the 13-adrenergic receptor(l-3). Extensive studies have demonstrated that agonist stimulation of the !3-adrenergic receptor results in phosphorylation of the receptor by two kinases; protein kinase A (PKA), and the receptor-specific kinase !3-adrenergic receptor kinase (GRK-2) (1-3). Each of these kinases phosphorylates distinct sites on the receptor. PKA sites are at RRSS motifs in the third intracellular loop and C-terminal tail (4), and GRK-2 sites are in
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Pinsky, Leonard, Robert P. Erickson, and R. Neil Schimke. "Genetic Disorders of Gonadotropin Action." In Genetic Disorders of Human Sexual Development. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780195109078.003.0011.

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Abstract The chorionic gonadotropin/luteinizing hormone receptor (henceforth, LHR), and the follicle-stimulating hormone receptor (FSHR) belong to the subfamily of G protein-coupled receptors for glycoprotein hormones. They share a very long (~ 350 amino acids) N-terminal extracellular domain devoted primarily to high-affinity ligand binding, seven membrane-spanning α-helices with six intervening loops (three each, internal and external), and a relatively short C-terminal intracellular domain (Fig. 11-1).
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Bernstein, A., and B. Motro. "Kit (Stem Cell or Steel Factor) Receptor." In Guidebook to Cytokines and Their Receptors. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198599470.003.0054.

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Abstract The human c-kit receptor gene encodes a 972-amino-acid precursor protein with a predicted 24-amino-acid leader sequence (GenBank accession number X06182) (Yarden et al. 1987). A single predicted transmembrane domain of 23 amino acids divides the protein into two major domains. The amino terminal extracellular 487 amino acids form the ligand-binding domain and are composed of five immunoglobulin-like loops. The predicted molecular weight of the receptor is 109000 but the observed molecular weight on SDS-PAGE gels is 145-160000 due to N-glycosylation at several of the nine potential gly
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Jahn, R., and T. C. Südhof. "Synaptophysin protein family." In Secretory Pathway. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198599425.003.0128.

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Abstract cDNAs encoding synaptophysin have been sequenced from several mammalian species (GenBank accession number for rat cDNA: X06177) and from Torpedo1·5They encode a protein of approximately 34,000 Daltons with four predicted transmembrane segments and the C- and N-termini facing the cytoplasm124·5. No signal sequence is observed, similar to all other synaptic vesicle membrane proteins cloned so far. The sequence contains two potential glycosylation sides and four cysteine residues, all located in the luminal loops. The cytoplasmic tail contains 10 copies of a unique pentapetpide repeat wi
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Conference papers on the topic "C-terminal loop"

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Hijikata-Okunomiya, A., S. Okamoto, R. Kikumoto, and Y. Tamao. "STEREOGEOMETRY OP THE ACTIVE SITES OF SERINE ENZYMES GATHERED FROM SYNTHETIC THROMBIN-INHIBITORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644606.

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MD-805 is a potent thrombin-inhibitor having the structure of tri-pods; Arg skeletone, N-terminal side and C-terminal side. MD-805 showed weaker inhibitory activity to other enzymes than thrombin. In this report, to gather more detailed informations about the structural features of serine enzymes concerning the specificity, we experimentally examined the structure-activity relationship (SAR) of a number of arginine derivatives including MD-805 and theoretically generated a MD-805-trypsin complex model using the results of X-ray crystallography of MD-805 and BPTI-trypsin complex by calculation
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polyphemus, Limulus, T. Muta, T. Miyata, F. Tokunaga, T. Nakamura, and S. Iwanaga. "PRIMARY STRUCTURE OF ANTI-LIPOPOLYSACCHARIDE FACTOR ISOLATED FROM AMERICAN HORSESHOE CRAB." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644608.

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In 1982, a protein component that inhibits the limulus coagulation cascade was found in the hemocyte lysates from Japanese and American horseshoe crabs and named anti-lipopolysaccharide (LPS) factor. This protein specifically inhibited the LPS-mediated activation of limulus factor C and had a strong anti-bacterial effect on the growth of Gram-negative R-type bacteria. Moreover, it had a hemolytic activity on the red blood cells sensitized with LPS.In the present study, the complete amino acid sequence of anti-LPS factor purified from the Limulus (L) polyphemus hemocytes was determined by chara
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Verhagen, Joris, Etienne Heymans, Darko Gjorgjievski, Arjan Voogt, and Frederik Van Nuffel. "Eemshaven LNG - Repurposing an FSRU Built for Tropical Conditions to Operate in the North Sea." In Offshore Technology Conference. OTC, 2023. http://dx.doi.org/10.4043/32586-ms.

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Abstract In 2017, Exmar has taken delivery of an FSRU which was intended to operate in Bangladesh to provide the country up to 600 MMSCFD of natural gas. The FSRU was purpose-built with a shallow draft to allow it to be moored in a river estuary. The project in Bangladesh never materialized and the FSRU ended up in lay-up in Singapore. With the energy crisis unfolding early 2022 several countries in Europe urgently started investigating the possibilities to bring FSRUs to Europe to ensure the security of natural gas supplies and in order to have a back-up for the decreasing natural gas flow fr
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Dahiback, Bjorn, Ake Lundwall, Andreas Hillarp, Johan Malm, and Johan Stenflo. "STRUCTURE AND FUNCTION OF VITAMIN K-DEPENDENT PROTEIN S, a cofactor to activated protein C which also interacts with the complement protein C4b-binding protein." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642960.

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Protein S is a single chain (Mr 75.000) plasma protein. It is a cofactor to activated protein C (APC) in the regulation of coagulation factors Va and Villa. It has high affinity for negatively charged phospolipids and it forms a 1:1 complex with APC on phospholipid surfaces, platelets and on endothelial cells. Patients with heterozygous protein S deficiency have a high incidence of thrombosis. Protein S is cleaved by thrombin, which leads to a loss of calcium binding sites and of APC cofactor activity. Protein S has two to three high affinity (KD 20uM) calcium binding sites - unrelated to the
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Soares, Luigi, and Fernando Magno Quintão Pereira. "Memory-Safe Elimination of Side Channels." In Concurso de Teses e Dissertações. Sociedade Brasileira de Computação - SBC, 2023. http://dx.doi.org/10.5753/ctd.2023.229445.

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In this project, we find a new service for partial control-flow linearization (PCFL), a code transformation initially conceived to maximize work performed in vectorized programs. We show that PCFL can be employed as a defense mechanism against timing attacks. This transformation is sound: given an instance of its public inputs, the partially linearized program always runs the same sequence of instructions, regardless of secret inputs. Incidentally, if the original program is publicly safe, then accesses to the data cache will be data oblivious in the transformed code. The transformation is opt
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Soukup, Todd J., and Vincent P. Heuring. "Implementation of a Fiber Optic Delay Line Memory." In Optical Computing. Optica Publishing Group, 1991. http://dx.doi.org/10.1364/optcomp.1991.me14.

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The objective of the Digital Optical Computer (DOC) group at the University of Colorado at Boulder is to implement a general purpose computer using the speed advantages of light.[1] The machine is being implemented using lithium niobate directional couplers as logic elements and optical fiber loops for memory. Figure 1 shows the logic functionality of the directional coupler. Terminal C, normally an electronic input, has been converted to an optical input by the addition of a sensitive detector, amplifier, and thresholder.[2] This paper describes the implementation of the fiber optic delay lin
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Cacciatore, Francesco, Jorge Cardín, Guillermo Rodríguez, and Héctor Gutiérrez. "Space Rider Re-Entry Module Scaled Down Flight Test Campaign." In ESA 12th International Conference on Guidance Navigation and Control and 9th International Conference on Astrodynamics Tools and Techniques. ESA, 2023. http://dx.doi.org/10.5270/esa-gnc-icatt-2023-071.

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As part of the Space Rider’s (SR) verification and validation campaign of the Guidance, Navigation and Control (GNC) system for the flight under the parafoil phase, a series of Scale Down Flight Test (SDFT) are envisioned for phases C/D of the project. These tests have the following objectives for what concerns GNC: increasing the maturity level of the Parafoil GNC (PGNC), de-risking especially its novel terminal guidance approach in view of flight and for drop tests, provide a preliminary assessment of the real-life achievable landing accuracy, test onboard wind estimation, test robustness of
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Reports on the topic "C-terminal loop"

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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are
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