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Journal articles on the topic "C.T. Nelson Co"
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Moogk, Duane, Vivian Lau, Arya Afsahi, Anna Dvorkin-Gheva, Ksenia Bezverbnaya, Joanne Hammill, and Jonathan Bramson. "94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A105. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0094.
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BackgroundThe T cell Antigen Couper (TAC) is a chimeric receptor that redirects the endogenous T cell receptor (TCR) against a tumor target via an extracellular antigen-binding domain to induce activation and oncolysis. TAC-engineered T cells (TAC-T cells) showed a similar capacity to activate T cells against the tumor-associated antigen HER2 as their classical chimeric antigen receptor (CAR)-engineered counterparts in vitro. However, in a xenograft model, anti-HER2 CAR-T cells gave rise to lethal off-target toxicity while TAC-T cells were efficacious and well-tolerated, despite utilizing the same antigen-binding domain.1 2 Here, we describe differences in T cell activation by TAC (canonical via endogenous TCR) and CAR (non-canonical independent of TCR) that make CAR-T cells less discriminate towards an off-target stimulus than TAC-T cells.MethodsPaired sets of TAC- and CAR-engineered human T cells, utilizing a variety of antigen-binding domains, were compared in vitro to determine their propensity for tonic signaling and requirements for triggering T cell activation.ResultsTranscriptional profiling of CAR- and TAC- T cells in the absence of antigenic stimulus revealed an elevated basal activation status in CAR-T cells. Unstimulated CAR-T cells displayed elevated expression levels of activation and exhaustion markers, as well as basal cytokine production, versus their TAC-T cell counterparts. The degree of basal activation varied with the binding domain incorporated into the CAR, where some binding domains triggered functional exhaustion. Regardless of the binding domain, unstimulated TAC-T cells were indistinguishable from control T cells that expressed no synthetic receptor. Further, TAC-T cells displayed no evidence of functional exhaustion. TCR knock-out studies confirmed that TAC receptors signal via the endogenous TCR, whereas CAR signaling is TCR-independent. Consistent with TCR-dependent signaling, ligation of TAC receptors resulted in the formation of conventional immunological synapses, whereas ligation of CARs produced unconventional synapses. Despite these functional differences, CARs and TAC receptors demonstrated a similar capacity to activate T cells against antigen-positive tumor cell targets. However, CAR-T cells displayed reactivity to antigen-negative cells, due to interaction with a cross-reactive antigen; TAC-T cells displayed no reactivity to antigen-negative cells.ConclusionsTonic signaling in CAR-T cells reduces their activation threshold and increases their propensity to be activated by cross-reactive antigen. In contrast, TAC receptors do not deliver tonic signals, which increases the stringency of activation and reduces the likelihood of off-target responses. This feature of the TAC platform is advantageous to safeguard against the unexpected cross-reactivity that may occur when a new antigen-binding domain is deployed in vivo.Ethics ApprovalUse of human materials was approved by the Hamilton Integrated Research Ethics Board (HiREB).ReferencesHelsen C, Hammill JA, Lau VWC, Mwawasi KA, Afsahi A, Bezverbnaya K, Newhook L, Hayes DL, Aarts C, Bojovic B, Denisova GF, Kwiecien JM, Brain I, Derocher H, Milne K, Nelson BH, Bramson JL. The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity. Nat Commun 2018;9:3049.Hammill JA, Kwiecien JM, Dvorkin-Gheva A, Lau VWC, Baker C, Wu Y, Bezverbnaya K, Aarts C, Helsen CW, Denisova GF, Derocher H, Milne K, Nelson BH, Bramson JL. A cross-reactive small protein binding domain provides a model to study off-tumor CAR-T cell toxicity. Mol Ther Oncolytics 2020;17:278–292.
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Miller, Dean, Matthew Liu, and William Abraham Tarpeh. "Evaluating Molecular Catalyst-Mediated Nitrate Reduction for Reactive Separation and Recovery of Ammonia." ECS Meeting Abstracts MA2022-01, no. 40 (July 7, 2022): 1799. http://dx.doi.org/10.1149/ma2022-01401799mtgabs.
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The current state of centralized nitrogen (N) management has destabilized global environmental cycles via Haber-Bosch (HB) ammonia-N manufacturing which contributes 1.2% of global anthropogenic CO2-eq emissions.1 The majority of this N that is discharged to wastewaters goes untreated, leading to harmful algal blooms that threaten coastal and river ecosystems, which already costs the U.S. an estimated $210 billion per year in health and environmental damages.2 Furthermore, the production of HB ammonia, and the subsequent discharge of wastewater nitrogen, is expected to substantially increase in the next three decades as the human population climbs to 9 billion people.3 Simultaneously removing nitrogen pollutants and recovering value-added products can preserve national water quality and supplement supply chains of nitrogen consumables with renewably sourced electricity. The electrochemical nitrate reduction reaction (NO3RR) can be leveraged in reactive separation processes to convert wastewater nitrates to commodity products, such as ammonia. Engineering catalytic NO3RR processes that operate at feasible rates and faradaic efficiencies is challenging because the majority of nitrate-rich wastewaters (e.g., fertilizer runoff) are dilute in nitrate concentration (< 5 mM).4 Molecular catalysts are uniquely suited to reduce nitrate at low concentrations in real wastewaters due to their strong substrate recognition (reactant selectivity) and product selectivity. In this study, we benchmarked the performance of the molecular catalyst Co-DIM (a Co-N4 macrocycle complex and the only known molecular NO3RR catalyst selective for ammonia5) in a reactive separations process for the treatment of real, nitrate-rich wastewaters. We first demonstrated by cyclic voltammetry (CV) and controlled-potential electrolysis (CPE) that selective Co-DIM-mediated NO3RR is feasible in nitrate-rich secondary effluent (municipal wastewater after biological nitrification). We then employed Co-DIM in electrochemical stripping (ECS): a membrane-separated cell that facilitates reactive separation of produced ammonia.6,7 From real secondary effluent (28 mg NO3-N/L), we achieved greater than 60% nitrate removal with a faradaic efficiency of 25% and ammonia selectivity of 98%. However, the energy consumed for ECS per unit mass of N is 16 times the combined energy requirement for conventional wastewater N removal and HB ammonia synthesis. By introducing a mixed feed of ammonia- and nitrate-rich wastewater and performing electrodialysis (ED) to concentrate the reactant nitrate before ECS, the energy requirement for N removal and ammonia recovery was decreased by three times while the ED process became the dominant energy consumer in the overall process. Additionally, the increase in nitrate removal could not be explained by an increase in nitrate concentration alone. The ED process changes the concentrations and relative ratios of competing anions and buffering species, which can inhibit or promote the molecular electrocatalytic activity. We therefore explored a matrix of anion identities and concentrations by rotating-disk voltammetry and CPE to elucidate plausible inhibition and promotion mechanisms associated with catalyst activation and NO3RR catalysis. This study therefore (1) benchmarks current and future efforts to reactively separate ammonia from real nitrate-rich wastewater with a molecular catalyst and (2) highlights molecular and process-level improvements to realize a circular nitrogen economy. References 1 C. Smith, A. K. Hill and L. Torrente-Murciano, Energy Environ. Sci., 2020, 13, 331–344. 2 D. J. Sobota, J. E. Compton, M. L. McCrackin and S. Singh, Environ. Res. Lett., 2015, 10, 025006. 3 J. W. Erisman, M. A. Sutton, J. Galloway, Z. Klimont and W. Winiwarter, Nature Geoscience, 2008, 1, 636–639. 4 Unesco, Ed., Wastewater: the untapped resource, UNESCO, Paris, 2017. 5 S. Xu, D. C. Ashley, H.-Y. Kwon, G. R. Ware, C.-H. Chen, Y. Losovyj, X. Gao, E. Jakubikova and J. M. Smith, Chem. Sci., 2018, 9, 4950–4958. 6 W. A. Tarpeh, J. M. Barazesh, T. Y. Cath and K. L. Nelson, Environ. Sci. Technol., 2018, 52, 1453–1460. 7 M. J. Liu, B. S. Neo and W. A. Tarpeh, Water Research, 2020, 169, 115226.
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Lowery, Frank, Sri Krishna, Rami Yoseph, Neilesh Parikh, Praveen Chatani, Yong-Chen William Lu, Nikolaos Zacharakis, Paul Robbins, Maria Parkhurst, and Steven Rosenberg. "651 Molecular signature of neoantigen-reactive CD4+ and CD8+ T cells from metastatic human cancers enables prospective antitumor TCR prediction." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A680. http://dx.doi.org/10.1136/jitc-2021-sitc2021.651.
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BackgroundAutologous patient T cells engineered to express antitumor T cell receptors (TCRs) and chimeric antigen receptors (CARs) have been effective for the treatment of certain cancer types,1–4 and tumor neoantigens encoded by cancer-specific mutations have emerged as major targets of CD4+ and CD8+ T cells in immune checkpoint blockade (ICB) and in adoptive cell therapy (ACT).5–9 However, only a minority of intratumoral T cells are reactive to cancer antigens while the majority represent bystander cells.10–12 Conventional approaches to isolate tumor-reactive T cells and identify their TCRs from tumors rely on T cell function and can be impaired due to T cell exhaustion and dysfunction.13 14MethodsWe performed single-cell RNA and T cell receptor (TCR) sequencing (scRNA/TCR-seq) on over 46,000 T cells isolated from eleven archival metastatic tumor samples whose primary cancer types included colon, rectal, breast, anal, and melanoma. From these samples, 15 CD8+ and 17 CD4+ neoantigen-reactive TCR clonotypes (NeoTCRs) were known. We then performed transcriptomic clustering of these cells and mapped known NeoTCR clonotypes onto the transcriptomic map. Subsequently we predicted NeoTCRs from prospective metastatic colon cancer samples based on their presence within clusters sharing gene expression with NeoTCR+ clusters in the archival samples.ResultsProjecting known NeoTCRs onto the TIL transcriptomic map, we observed 325 total T cells bearing these NeoTCRs, and the majority (>80%) of NeoTCRs were expressed by T cells within 2 clusters, one CD4+ and one CD8+, that included by expression of CXCL13, ENTPD1 (CD39), TOX, TIGIT, LAG3, and PDCD1 (PD-1), indicating a dysfunctional state. Reasoning that T cells sharing phenotypes with those within the NeoTCR clusters could be novel NeoTCRs, we developed gene signatures (NeoTCR4 and NeoTCR8) of CD4 and CD8 NeoTCR+ cells, respectively, and four prospective patients' TIL were analyzed by scRNA/TCR-seq and scored according to NeoTCR signatures. We expressed predicted NeoTCRs in healthy donor PBL and screened them with antigen presenting cells (APCs) expressing candidate neoantigens. 33/73 predicted NeoTCRs (including both CD4 and CD8) were reactive against patients' tumors or candidate neoantigens.ConclusionsThis study enabled successful detection of tumor-specific NeoTCRs in the sequenced TIL of 14/14 patients for whom reactivity was studied. Deconvolution of NeoTCRs from bystander TCRs within the tumor-immune microenvironment represents an important step in the development of personalized immunotherapeutics, and prospective NeoTCR isolation based on TIL transcriptional phenotypes will allow for rapid development of personalized immunotherapy in the form of lymphocytes expressing these tumor-specific TCRs.AcknowledgementsWe thank the Surgery Branch TIL Laboratory and clinical team for generating TIL, and patients enrolled in our clinical protocols. Support from CCR Single Cell Analysis Facility was funded by FNLCR Contract HHSN261200800001E. This work utilized the computational resources of the NIH HPC Biowulf cluster (http://hpc.nih.gov). We also thank NIDAP for providing additional computational support and the CCR Genomics Core for next-generation sequencing supportReferencesRobbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, Kammula US, Hughes MS, Restifo NP, Raffeld M, Lee CCR, Levy CL, Li YF, El-Gamil M, Schwarz SL, Laurencot C, Rosenberg SA.Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol 2011;29:917–924.Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, Royal RE, Topalian SL, Kammula US, Restifo NP, Zheng Z, Nahvi A, de Vries CR, Rogers-Freezer LJ, Mavroukakis SA, Rosenberg SA. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006;314:126–129.June CH, Sadelain M. Chimeric Antigen Receptor Therapy. N Engl J Med 2018;379:64–73.Kochenderfer JN, Yu Z, Frasheri D, Restifo NP, Rosenberg SA. Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells. Blood 2010;116:3875–3886.Tran E, Robbins PF, Rosenberg SA, “Final common pathway” of human cancer immunotherapy: targeting random somatic mutations. Nat Immunol 2017;18:255–262.Robbins PF, Lu YC, El-Gamil M, Li YF, Gross C, Gartner J, Lin JC, Teer JK, Cliften P, Tycksen E, Samuels Y, Rosenberg SA, Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med 2013;19:747–752.Parkhurst MR, Robbins PF, Tran E, Prickett TD, Gartner JJ, Jia L, Ivey G, Li YF, El-Gamil M, Lalani A, Crystal JS, Sachs A, Groh E, Ray S, Ngo LT, Kivitz S, Pasetto A, Yossef R, Lowery FJ, Goff SL, Lo W, Cafri G, Deniger DC, Malekzadeh P, Ahmadzadeh M, Wunderlich JR, Somerville RPT, Rosenberg SA. Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers. Cancer Discov 2019;9:1022–1035.Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SSK, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJM, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 2014;515:577–581.van Rooij N, van Buuren MM, Philips D, Velds A, Toebes M, Heemskerk B, van Dijk LJA, Behjati S, Hilkmann H, el Atmioui D, Nieuwland M, Stratton MR, Kerkhoven RM, Keşmir C, Haanen JB, Kvistborg P, Schumacher TN. Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma. Journal of Clinical Oncology 2013;31:e439–e442.Duhen T, Duhen R, Montler R, Moses J, Moudgil T, de Miranda NF, Goodall CP, Blair TC, Fox BA, McDermott JE, Chang SC, Grunkemeier G, Leidner R, Bell RB, Weinberg AD. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. Nat Commun 2018;9:2724.Simoni Y, Becht E, Fehlings M, Loh CY, Koo SL, Teng KWW, Yeong JPS, Nahar R, Zhang T, Kared H, Duan K, Ang N, Poidinger M, Lee YY, Larbi A, Khng AJ, Tan E, Fu C, Mathew R, Teo M, Lim WT, Toh CK, Ong BH, Koh T, Hillmer AM, Takano A, Lim TKH, Tan EH, Zhai W, Tan DSW, Tan IB, Newell EW, Bystander CD8 T cells are abundant and phenotypically distinct in human tumour infiltrates. Nature 2018;557:575–579.Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, Kenter G, Voest EE, Haanen JBAG, Schumacher TN. Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nat Med 2019;25:89–94.Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D. Defining “T cell exhaustion.” Nat Rev Immunol 2019;19:665–674.van der Leun AM, Thommen DS, Schumacher TN. CD8 T cell states in human cancer: insights from single-cell analysis. Nat Rev Cancer 2020;20:218–232.
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Grahame, J. A. K., R. A. Butlin, James G. Cruickshank, E. A. Colhoun, A. Farrington, Gordon L. Davies, I. E. Jones, et al. "Reviews of Books." Irish Geography 5, no. 2 (January 4, 2017): 106–508. http://dx.doi.org/10.55650/igj.1965.1015.
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NORTHERN IRELAND FROM THE AIR. Edited by R. Common, Belfast : Queen's University Geography Department, 1964. 104 pp., 44 plates, 1 folding map. 10 × 8 ins. 25s.THE CANALS OF THE NORTH OF IRELAND, by W. A. McCutcheon. Dawlish : David and Charles, and London : Macdonald and Co., 1965. 180 pp. 8 1/2 × 5 1/4 in. 36s.ULSTER AND OTHER IRISH MAPS c.1600. Edited by G. A. Hayes‐McCoy. Dublin : Irish Manuscripts Commission, 1964. 13 × 19 in. xv + 36 pp., 23. plates. £ 6.SOILS OF COUNTY WEXFORD. Edited by P. Ryan and M. J. Gardiner. Prepared and published by An Foras Talúntais (The Agricultural Institute), Dublin 1964. 171 pp. and three fold‐in maps. 30s.THE GEOGRAPHY OF SOIL, by Brian T. Bunting. London : Hutchinson's University Library, 1965. pp. 213. 14 figs. 12 tables. 7 1/2 × 5 in. 15s.THE HISTORY OF THE STUDY OF LANDFORMS. Vol. I : GEOMORPHOLOGY BEFORE DAVIS. Richard J. Chorley, Anthony J. Dunn and Robert P. Beckinsale. London : Methuen, 1964. 678 pp. 84s.A DICTIONARY OF GEOGRAPHY, by F. J. Monkhouse. London : Edward. Arnold Ltd., 1965. 344 pp. 8 1/2 × 5 1/2 in. 35s.LA REGION DE L'OUEST, by Pierre Flatrès. Collection ‘France de Demain ‘. Paris : Presses Universitaires de France, 1964. 31s. 6d.THE BRITISH ISLES : A SYSTEMATIC GEOGRAPHY. Edited by J. Wreford Watson and J. B. Sissons. Edinburgh : Thomas Nelson, 1964. 452 pp. 45s.SCANDINAVIAN LANDS, by Roy Millward. London : Macmillan, 1964. Pp. 448. 9 × 6 in. 45s.MERSEYSIDE, by R. Kay Gresswell and R. Lawton. British Landscapes Through Maps, No. 6. The Geographical Association, Sheffield, 1964. 36 pp. + 16 plates. 7 1/2 × 9 1/2 in. 5s.WALKING IN WICKLOW, by J. B. Malone. Dublin : Helicon Ltd., 1964. 172 pp. 7 × 4 #fr1/2> in. 7s.GREYSTONES 1864–1964. A parish centenary, 1964. 23 pp. 8 #fr1/4> × 5 1/2 in. 2s. 6d. Obtainable from the A.P.C.K., 37 Dawson Street, Dublin 2.DINNSEANCHAS. Vol. I, No. I. June 1964. An Cumann Logainmneacha, Baile Atha Cliath. Pp. 24. 5s.JOURNAL OF THE ASSOCIATION OF GEOGRAPHY TEACHERS OF IRELAND. Vol. I, Dublin. 1964.MAP READING FOR THE INTERMEDIATE CERTIFICATE, by Michael J. Turner. A. Folens : Dublin. 1964. 92 pp.MAP OF CORK CITY, 1: 15,000. Dublin : Ordnance Survey Office, 1964. 32 × 24 in. On paper, flat, 4s., or folded and covered, 5s.IRELAND, by T. W. Freeman. London : Methuen & Co. Ltd. Third edition, 1965. 5 1/2 × 8 #fr1/2> in. Pp. xx + 560. 65s.THE PLANNING AND FUTURE DEVELOPMENT OF THE DUBLIN REGION. PRELIMINARY REPORT. By Myles Wright. Dublin : Stationery Office, 1965. Pp.55. 8 ins. × 11 3/4 ins. 10s 6d.LIMERICK REGIONAL PLAN. Interim Report on the Limerick—Shannon— Ennis District by Nathaniel Litchfield. The Stationery Office, Dublin 1965. 8 × 12 ins. ; Pp. 83 ; 10s. 6d.ANTRIM NEW TOWN. Outline Plan. Belfast : H. M. Stationery Office, 1965. 10 1/2 × 8 1/2 in. 15s.HEPORT OF THE DEPUTY KEEPER OF THE RECORDS 1954–1959. Belfast : Her Majesty's Stationery Office. Cmd. 490. 138 pp. 10s.ECONOMIC GEOGRAPHY, by Ronald Hope. London : George Philip and Son Ltd., 4th edition, 1965. pp. 296. 15s. 6d.CLIMATE, SOILS AND VEGETATION, by D. C. Money. London : University Tutorial Press, 1965. pp. 272. 18s.TECHNIQUES IN GEOMORPHOLOGY, by Cuchlaine A. M. King. 9 × 5 1/2 in. 342 pp. London : Edward Arnold (Publishers) Ltd., 1966. 40s.BRITISH GEOMORPHOLOGICAL RESEARCH GROUP PUBLICATIONS :— 1. RATES OF EROSION AND WEATHERING IN THE BRITISH ISLES. Occasional Publication No. 2, 1965. Pp. 46. 13 × 8 in. 7s. 6d.2. DEGLACIATION. Occasional Publication No. 3, 1966. Pp. 37. 13 × 8 in. 7s.RECHERCHES DE GÉOMORPHOLOGIE EN ÉCOSSE DU NORD‐OUEST. By A. Godard. Publication de la Faculté des Lettres de l'Université de Strasbourg, 1965. 701 pp. 482 reís.ARTHUR'S SEAT: A HISTORY OF EDINBURGH'S VOLCANO, by G. P. Black. Edinburgh & London : Oliver & Boyd, 1966. 226 pp. 7 1/2 × 5 in. 35s.OFFSHORE GEOGRAPHY OF NORTHWESTERN EUROPE. The Political and Economic Problems of Delimitation and Control, by Lewis M. Alexander. London : Murray, 1966. 35s.GEOGRAPHICAL PIVOTS OF HISTORY. An Inaugural Lecture, by W. Kirk. Leicester University Press, 1965. 6s.THE GEOGRAPHY OF FRONTIERS AND BOUNDARIES, by J. R. V. Prescott. London : Hutchinson, 1965. 15s.THE READER'S DIGEST COMPLETE ATLAS OF THE BRITISH ISLES.. London : Reader's Digest Assoc., 1965. 230 pp. 15 1/4 × 10 1/2 in. £5. 10. 0.ULSTER DIALECTS. AN INTRODUCTORY SYMPOSIUM. Edited by G. B. Adams, Belfast : Ulster Folk Museum, 1964. 201 pp. 9 1/2 × 6 1/2 in. 20s.ULSTER FOLKLIFE, Volume 11. Belfast: The Ulster Folk Museum, 1965. Pp. 139. 9 1/2 × 7 in. 15s.GEOGRAPHICAL ABSTRACTS published and edited by K. M. Clayton, F. M Yates, F. E. Hamilton and C. Board.Obtainable from Geo. Abstracts, Dept. of Geography, London School of Economics, Aldwych, London, W.C.2. Subscription rates as below.THE CLIMATE OF LONDON. T. J. Chandler. London : Hutchinson and Co., 1965. 292 pp., 86 figs., 93 tables. 70/‐.MONSOON LANDS, Part I, by R. T. Cobb and L. J. M. Coleby. London : University Tutorial Press Ltd., 1966, constituting Book Six (Part 1 ) of the Advanced Level Geography Series. 303 pp. 8 1/4 × 5 1/4 in. 20s.PREHISTORIC AND EARLY CHRISTIAN IRELAND. A GUIDE, by Estyn Evans. London : B. T. Batsford Ltd., 1966. xii + 241 pp. 45s.A REGIONAL GEOGRAPHY OF IRELAND, by G. Fahy. Dublin : Browne and Nolan Ltd. No date. 238 pp. 12s.THE CANALS OF THE SOUTH OF IRELAND, by V. T. H. and D. R. Delany. Newton Abbot : David and Charles, 1966. 260 pp. + 20 plates. 8 1/2 × 5 1/2 in. 50s.THE COURSE OF IRISH HISTORY. Edited by T. W. Moody and F. X. Martin. Cork : The Mercier Press. 1967. 404 pp. 5 3/4 × 7 3/4 ins. Paperback, 21s. Hard cover, 40s.NORTH MUNSTER STUDIES. Edited by E. Rynne. Limerick : The Thomond Archaeological Society, 1967. 535 pp. 63s.SOILS OF COUNTY LIMERICK, by T. F. Finch and Pierce Ryan. Dublin: An Foras Talúntais, 1966. 199 pp. and four fold‐in maps. 9 1/2 × 7 1/4 in. 30s.THE FORESTS OF IRELAND. Edited by H. M. Fitzpatrick. Dublin : Society of Irish Foresters. No date. 153 pp. 9 3/4 × 7 1/4 in. 30s.PLANNING FOR AMENITY AND TOURISM. Specimen Development Plan Manual 2–3, Donegal. Dublin : An Foras Forbartha (The National Institute for Physical Planning and Construction Research), 1966. 110 pp. 8 × 11 in. 12s. 6d.NEW DIMENSIONS IN REGIONAL PLANNING. A CASE STUDY OF IRELAND, by Jeremiah Newman. Dublin : An Foras Forbartha, 1967. 128 pp. 8 1/2 × 6 in. 25s.TRAFFIC PLANNING FOR SMALLER TOWNS. Dublin : An Foras Forbartha (The National Institute for Regional Planning and Construction Research), 1966. 35 pp. 8 1/4 × 10 3/4 in. No price.LATE AND POST‐GLACIAL SHORELINES AND ICE LIMITS IN ARGYLL AND NORTH‐EAST ULSTER, by F. M. Synge and N. Stephens. Institute of British Geographers Transactions No. 59, 1966, pp. 101–125.QUATERNARY CHANGES OF SEA‐LEVEL IN IRELAND, by A. R. Orme. Institute of British Geographers Transactions No. 39, 1966, pp. 127–140.LIMESTONE PAVEMENTS (with special reference to Western Ireland), by Paul W. Williams. Institute of British Geographers Transactions No. 40, 1966, pp. 155–172. 50s. for 198 pages.IRISH SPELEOLOGY. Volume I, No. 2, 1966. Pp. 18. 10 × 8 in. 5s., free to members of the Irish Speleological Association.THE GEOGRAPHER'S CRAFT, by T. W. Freeman. Manchester University Press, 1967. pp.204. 8 1/4 × 5 in. 25s.GEOGRAPHY AS HUMAN ECOLOGY. Edited by S. R. Eyre and G. R. J. Jones. London : Edward Arnold Ltd., 1966. 308 pp. 45s.LOCATIONAL ANALYSIS IN HUMAN GEOGRAPHY, by Peter Haggett. London : Edward Arnold (Publishers) Ltd., 1965. 339 pp. 9 × 5 1/2 in. 40s.AGRICULTURAL GEOGRAPHY, by Leslie Symons. London : G. Bell and Sons, Ltd., 1967. 283 pp. 8 1/2 × 5 1/2 ins. 30s.THE GEOLOGY OF SCOTLAND, edited by Gordon Y. Craig. Edinburgh and London : Oliver & Boyd, 1965. Pp. 556. 9 3/4 × 7 1/2 in. 105s.MORPHOLOGY OF THE EARTH, by Lester C. King. Edinburgh : Oliver and Boyd, 2nd ed., 1967. 726 pp. 9 1/2 × 7 in. £5. 5. 0.INTERNATIONAL YEARBOOK OF CARTOGRAPHY, V, 1965. Edited by Eduard Imhof. London : George Philip and Son Ltd., 1965. 222 pp. + 9 plates. 9 3/4 × 6 1/2 in. 47s. 6d.IRISH FOLK WAYS, by E. Estyn Evans. London : Routledge and Kegan Paul, 1967. 324 pp. 16s.A HISTORY OF MEDIEVAL IRELAND, by A.J.Otway‐Ruthven. London: Ernest Benn Limited. New York : Barnes and Noble Inc., 1968. xv + 454 pp. 70s.IRISH AGRICULTURAL PRODUCTION, ITS VOLUME AND STRUCTURE, by Raymond D. Crotty. Cork University Press, 1966. 384 pp. 42s.PLANNING IN IRELAND. Edited by F. Rogerson and P. O hUiginn. Dublin : The Irish Branch of the Town Planning Institute and An Foras Forbartha, 1907. 199 pp.THE SHELL GUIDE TO IRELAND, by Lord Killanin and Michael V. Duignan. London : Ebury Press and George Rainbird (distributed by Michael Joseph) : 2nd edition, 1967. 512 pp. 50s.THE CLIMATE OF NORTH MUNSTER, by P. K. Rohan. Dublin : Department of Transport and Power, Meteorological Service, 1968. 72 pp. 10s. 6d.SOILS OF COUNTY CARLOW, by M.J. Conry and Pierce Ryan. Dublin : An Foras Talúntais, 1967. 204 pp. and four fold‐in maps. 30s.MOURNE COUNTRY, by E. Estyn Evans. Dundalk : Dundalgan Press (W. Tempest) Ltd., 2nd ed., 1967. 244 pp. 63s.THE DUBLIN REGION. Advisory Plan and Final Report, by Myles Wright. Dublin : The Stationery Office, 1967. Part One, pp. 64. 20s. Part Two, pp. 224. 80s.BELFAST : THE ORIGIN AND GROWTH OF AN INDUSTRIAL CITY. Edited by J. C. Beckett and R. E. Glasscock. London : The British Broadcasting Corporation, 1967. 204 pp. 25s.REPORT ON SKIBBEREEN SOCIAL SURVEY, by John Jackson. Dublin : Human Sciences Committee of the Irish National Productivity Committee, 1967. 63 pp. 12s. 6d.AN OUTLINE PLAN FOR GALWAY CITY, by Breandan S. MacAodha. Dublin : Scepter Publishers Ltd., 1966. 15 pp.COASTAL PASSENGER STEAMERS AND INLAND NAVIGATIONS IN THE SOUTH OF IRELAND, by D.B. McNeill. Belfast : The Transport Museum (Transport Handbook No. 6), 1965 (issued in 1967). 44 pp. (text) + 12 pp. (plates). 3s. 6d.CANALIANA, the annual bulletin of Robertstown Muintir na Tire. Robertstown, Co. Kildare : Muintir na Tire, n.d. (issued in 1967). 60 pp. 2s. 6d.CONACRE IN IRELAND, by Breandan S. MacAodha (Social Sciences Research Centre, Galway). Dublin : Scepter Publishers Ltd., 1967, 15 pp. No price.PROCESSES OF COASTAL DEVELOPMENT, by V.P. Zenkovich, edited by J.A. Steers, translated by D.G. Fry. 738 pp. Edinburgh and London : Oliver and Boyd, 1967. £12. 12s.CONGRESS PROCEEDINGS. 20th International Geographical Congress. Edited by J. Wreford Watson. London : Nelson, 1967. 401 pp. 70s.REGIONAL GEOGRAPHY, by Roger Minshull. London : Hutchinson University Library, 1967. 168 pp. 10s. 6d.ATMOSPHERE, WEATHER AND CLIMATE, by R.G. Barry and R.J. Chorley. London : University Paperback, Methuen, 1967. 25s.THE EVOLUTION OF SCOTLAND'S SCENERY, by J.B. Sissons. Edinburgh and London : Oliver and Boyd, 1967. 259 pp. 63s.WEST WICKLOW. BACKGROUND FOR DEVELOPMENT, by F.H.A. Aalen, D.A. Gillmor and P.W. Williams. Dublin : Geography Department, Trinity College, 1966. 323 pp. Unpublished : copy available in the Society's Library.
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Buchele, Sebastian, Thomas Boulanger, Eric R. Logan, Louis Hartmann, Ahmed Eldesoky, Saad Azam, Tina Taskovic, Michel Johnson, and Michael Metzger. "Towards a Better Understanding of Redox Shuttle Generation in Lfp/Graphite and NMC811/Graphite Cells By Systematic Investigation of Different Electrolyte Additives." ECS Meeting Abstracts MA2022-02, no. 3 (October 9, 2022): 206. http://dx.doi.org/10.1149/ma2022-023206mtgabs.
Full textAbstract:
Recent observations by our group show the creation of a reversible shuttle species in LFP/graphite and NMC811/graphite cells with 3:7 ethylene carbonate:dimethyl carbonate (EC:DMC) based electrolytes. This is indicated by a high reversible self-discharge of these cells in the absence of electrolyte additives. Electrolyte extraction from pouch cells after formation allowed to directly investigate the electrolytes for redox shuttle currents. For this purpose, the extracted electrolytes were inserted into coin cells with an Al foil as the working electrode (WE) and a Li foil as the counter electrode (CE). The measured cyclic voltammetry (CV) of the coin cells show a clear relationship between high formation temperature and high shuttle currents. Interestingly, the addition of vinylene carbonate (VC) to the electrolyte completely prevents the shuttle current, even at elevated formation temperatures. [1] In this study, we systematically investigate the effect of various electrolyte additives on the generation of shuttle molecules. LFP/graphite and NMC811/graphite pouch cells were filled with electrolyte consisting of 3:7 EC:DMC with 1.5 M lithium hexafluorophosphate (LiPF6) and different additives. The pouch cells were formed at different temperatures, TF. The electrolytes were then extracted and inserted into the aforementioned coin cell setup for CV measurements. We have found that additives such as VC, fluoroethylene carbonate (FEC), ethylene sulfate (DTD), prop-1-ene-1,3-sultone (PES), and triallyl phosphate (TAP), which are known to create a stable solid electrolyte interphase (SEI), [2-4] prevent shuttle current in the CV. On the other hand, additives such as succinonitrile (SN) and trimethylsilyl isothiocyanate (TMSNCS), which do not contribute to the formation of a better SEI, [5,6] cannot prevent the shuttle current. This suggests that the formation of the shuttles is due to a poor SEI and therefore occurs at the interface between electrolyte and graphite anode. Analogue experiments with DMC as only solvent instead of 3:7 EC:DMC show similar shuttle currents in CVs, which suggests that linear carbonates such as DMC are required to form the shuttle. Figure 1 shows CVs for 1.5 M LiPF6 DMC electrolyte. The shuttle current appears to be the same for electrolyte extracted from LFP/graphite and NMC811/graphite cells ranging up to 6 μA in both cases. This indicates that the shuttle is formed independently of the cathode material, and therefore gives rise to the hypothesis that it is formed at the anode-electrolyte interface. Figure 1 also shows that the shuttle current increases with higher formation temperatures TF. References: Boulanger, A. Eldesoky. S. Buechele, T. Taskovic, S. Azam, C. Aiken, E. Logan, M. Metzger, Investigation of redox shuttle generation in LFP/graphite and NMC811/graphite cells, Submitted (2022). Song, J. Harlow, E. Logan, H. Hebecker, M. Coon, L. Molino, M. Johnson, J. Dahn, M. Metzger, A Systematic Study of Electrolyte Additives in Single Crystal and Bimodal LiNi 0.8 Mn 0.1 Co 0.1 O 2 /Graphite Pouch Cells , J. Electrochem. Soc. 168 (2021) 090503. doi:10.1149/1945-7111/ac1e55. J. Nelson, J. Xia, J.R. Dahn, Studies of the Effect of Varying Prop-1-ene-1,3-sultone Content in Lithium Ion Pouch Cells, J. Electrochem. Soc. 161 (2014) A1884–A1889. doi:10.1149/2.0791412jes. Xia, L. Madec, L. Ma, L.D. Ellis, W. Qiu, K.J. Nelson, Z. Lu, J.R. Dahn, Study of triallyl phosphate as an electrolyte additive for high voltage lithium-ion cells, J. Power Sources. 295 (2015) 203–211. doi:10.1016/j.jpowsour.2015.06.151. Chen, F. Liu, Y. Chen, Y. Ye, Y. Huang, F. Wu, L. Li, An investigation of functionalized electrolyte using succinonitrile additive for high voltage lithium-ion batteries, J. Power Sources. 306 (2016) 70–77. doi:10.1016/j.jpowsour.2015.10.105. G. Han, M.Y. Jeong, K. Kim, C. Park, C.H. Sung, D.W. Bak, K.H. Kim, K.M. Jeong, N.S. Choi, An electrolyte additive capable of scavenging HF and PF5 enables fast charging of lithium-ion batteries in LiPF6-based electrolytes, J. Power Sources. 446 (2020) 227366. doi:10.1016/j.jpowsour.2019.227366. Acknowledgements This work was funded under the auspices of the NSERC/Tesla Canada Alliance Grant program. Figure 1
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Leibo, Steven A., Abraham D. Kriegel, Roger D. Tate, Raymond J. Jirran, Bullitt Lowry, Sanford Gutman, Thomas T. Lewis, et al. "Book Reviews." Teaching History: A Journal of Methods 12, no. 2 (May 5, 1987): 28–47. http://dx.doi.org/10.33043/th.12.2.28-47.
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David K. Dunaway and Willa K. Baum, eds. Oral History: An Interdisciplinary Anthology. Nashville: American Assocation for State and Local History, 1984. Pp. xxiii, 436. Paper, $17.95 ($16.15 to AASLH members); cloth $29.50 ($26.95 to AASLH members). Review by Jacob L. Susskind of The Pennsylvania State University at Harrisburg. Salo W. Baron. The Contemporary Relevance of History: A Study in Approaches and Methods. New York: Columbia University Press, 1986. Pp. viii, 158. Cloth, $30.00; Stephen Vaughn, ed. The Vital Past: Writings on the Uses of History. Athens: The University of Georgia Press, 1985. Pp. 406. Paper, $12.95. Review by Michael T. Isenberg of the United States Naval Academy. Howard Budin, Diana S. Kendall and James Lengel. Using Computers in the Social Studies. New York and London: Teachers College Press, 1986. Pp. vii, 118. Paper, $11.95. Review by Francis P. Lynch of Central Connecticut State University. David F. Noble. Forces of Production: A Social History of Industrial Automation. New York and Oxford: Oxford University Press, 1984. Pp. xviii, 409. Paper, $8.95. Review by Donn C. Neal of the Society of American Archivists. Alan L. Lockwood and David E. Harris. Reasoning with Democratic Values: Ethical Problems in United States History. New York and London: Teachers College Press, 1985. Volume 1: Pp. vii, 206. Paper, $8.95. Volume 2: Pp. vii, 319. Paper, $11.95. Instructor's Manual: Pp. 167. Paper, $11.95. Review by Robert W. Sellen of Georgia State University. James Atkins Shackford. David Crocketts: The Man and the Legend. Chapel Hill: The University of North Carolina Press, 1986. Pp. xxv, 338. Paper, $10.95. Review by George W. Geib of Butler University. John R. Wunder, ed. At Home on the Range: Essays on the History of Western Social and Domestic Life. Westport, Connecticut: Greenwood Press, 1985. Pp. xiii, 213. Cloth, $29.95. Review by Richard N. Ellis of Fort Lewis College. Sylvia R. Frey and Marian J. Morton, eds. New World, New Roles: A Documentary History of Women in Pre-Industrial America. New York, Westport, Connecticut, and London: Greenwood Press, 1986. Pp. ix, 246. Cloth, $35.00. Review by Barbara J. Steinson of DePauw University. Elizabeth Roberts. A Woman's Place: An Oral History of Working-Class Women, 1890-1940. New York: Basil Blackwell, 1985. Pp. vii, 246. Paper, $12.95. Review by Thomas T. Lewis of Mount Senario College. Steven Ozment. When Fathers Ruled: Family Life in Reformation Europe. Cambridge, Massachusetts, and London: Harvard University Press, 1983. Pp. viii, 283. Cloth, $17.50; Paper, $7.50. Review by Sanford Gutman of State University of New York, College at Cortland. Geoffrey Best. War and Society in Revolutionary Europe, 1770-1870. New York: Oxford University Press, 1986. Pp. 336. Paper, $9.95; Brian Bond. War and Society in Europe, 1870-1970. New York: Oxford University Press, 1986. Pp. 256. Paper, $9.95. Review by Bullitt Lowry of North Texas State University. Edward Norman. Roman Catholicism in England: From the Elizabethan Settlement to the Second Vatican Council. Oxford and New York: Oxford University Press, 1986. Pp. 138. Paper, $8.95; Karl F. Morrison, ed. The Church in the Roman Empire. Chicago and London: University of Chicago Press, 1986. Pp. viii, 248. Cloth, $20.00; Paper, $7.95. Review by Raymond J. Jirran of Thomas Nelson Community College. Keith Robbins. The First World War. New York and Oxford: Oxford University Press, 1984. Pp. 186. Paper, $6.95; J. M. Winter. The Great War and the British People. Cambridge: Harvard University Press, 1986. Pp. xiv, 360. Cloth, $25.00. Review by Roger D. Tate of Somerset Community College. Gerhardt Hoffmeister and Frederic C. Tubach. Germany: 2000 Years-- Volume III, From the Nazi Era to the Present. New York: The Ungar Publishing Co., 1986. Pp. ix, 279. Cloth, $24.50. Review by Abraham D. Kriegel of Memphis State University. Judith M. Brown. Modern India: The Origins of an Asian Democracy. Oxford and New York: Oxford University Press, 1985. Pp. xvi, 429. Cloth, $29.95; Paper, $12.95. Review by Steven A. Leibo of Russell Sage College.
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Kneeshaw, Stephen, Richard Harvey, D'Ann Campbell, Robert W. Dubay, John T. Reilly, James F. Marran, Ann W. Ellis, et al. "Book Reviews." Teaching History: A Journal of Methods 10, no. 2 (May 4, 2020): 82–96. http://dx.doi.org/10.33043/th.10.2.82-96.
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Robert William Fogel and G. R. Elton. Which Road to the Past? Two Views of History. New Haven and London: Yale University Press, 1983. Pp. vii, 136. Cloth, $14.95. Review by Stephen Kneeshaw of The School of the Ozarks. Emmanuel LeRoy Ladurie. The Mind and Method of the Historian. Translated by Sian Reynolds and Ben Reynolds. Chicago: University of Chicago Press, 1981. Pp. v, 310. Paper, $9.95. Review by Richard Harvey of Ohio University. John E. O'Connor, ed. American History/ American Television: Interpreting the Video Past. New York: Frederick Ungar Publishing Company, 1983. Pp. 463. Cloth, $17.50; Paper, $8.95. Review by D' Ann Campbell of Indiana University. Foster Rhea Dulles & Melvyn Dubofsky. Labor in America: A History. Arlington Heights, Illinois: Harlan Davidson, Inc., 1984. 4th edition. Pp. ix, 425. Cloth, $25.95. Paper, $15.95. Review by Robert W. Dubay of Bainbridge Junior College. Karen Ordahl Kupperman. Roanoke: The Abandoned Colony. Totowa, New Jersey: Rowman & Allanheld, 1984. Pp. viii, 182. Cloth, $24.95; Paper, $12.50. Review by John T. Reilly of Mount Saint Mary College. Kevin O'Reilly. Critical Thinking in American History: Exploration to Constitution. South Hamilton, Massachusetts: Hamilton-Wenham Regional High School, 1983. Pp. 86. Paper, $2.95. Teacher's Guides: Pp. 180. Paper, $12.95; Kevin O'Reilly. Critical Thinking in American History: New Republic to Civil War. South Hamilton, Massachusetts: Hamilton-Wenham Regional High School, 1984. Pp. 106. Paper, $2.95. Teacher's Guide: Pp. 190. Paper, $12.95. Review by James F. Marran of New Trier Township High School, Winnetka, Illinois. Michael J. Cassity, ed. Chains of Fear: American Race Relations Since Reconstruction. Westport, Connecticut: Greenwood Press, 1984. Pp. xxxv, 253. Cloth, $35.00. Review by Ann W. Ellis of Kennesaw College. L. P. Morris. Eastern Europe Since 1945. London and Exeter, New Hampshire: Heinemann Educational Books, 1984. Pp. 211. Paper, $10.00. Review by Thomas T. Lewis, Mount Senario College. John Marks. Science and the Making of the Modern World. Portsmouth, New Hampshire: Heinemann Educational Books, Inc., 1983. Pp. xii, 507. Paper, $25.00. Review by Howard A. Barnes of Winston-Salem State University. Kenneth G. Alfers, Cecil Larry Pool, William F. Mugleston, eds. American's Second Century: Topical Readings, 1865-Present. Dubuque, Iowa: Kendall/ Hunt Publishing Co., 1984. Pp. viii, 381. Paper, $8.95. Review by Richard D. Schubart of Phillips Exeter Academy. Sam C. Sarkesian. America's Forgotten Wars: The Counterrevoltuionary Past and Lessons for the Future. Westport, Connecticut: Greenwood Press, 1984. Pp. xiv, 265. Cloth, $29.95. Review by Richard Selcer of Mountain View College. Edward Wagenknecht. Daughters of the Covenant: Portraits of Six Jewish Women. Amherst: University of Massachusetts, 1983. Pp. viii, 192. Cloth, $17.50. Review by Abraham D. Kriegel of Memphis State University. Morton Borden. Jews, Turks, and Infidels. Chapel Hill and London: University of North Carolina Press, 1984. Pp. x, 163. Cloth, $17.95. Review by Raymond J. Jirran of Thomas Nelson Community College. Richard Schlatter, ed. Recent Views on British History: Essays on Historical Writing Since 1966. New Brunswick: Rutgers University Press, 1984. Pp. xiii, 524. Cloth, $50.00. Review by Fred R. van Hartesveldt of Fort Valley State College. Simon Hornblower. The Greek World, 479-323 B.C. London and New York: Methuen, 1983. Pp. xi, 354. Cloth, $24.00; Paper, $11.95. Review by Dan Levinson of Thayer Academy, Braintree, Massachusetts. H. R. Kedward. Resistance in Vichy France. New York: Oxford University Press, 1978. Paper edition 1983. Pp. ix, 311. Paper, $13.95. Review by Sanford J. Gutman of the State University of New York at Cortland.
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Luangwilai, Thiansiri, Harvinder Sidhu, and Mark Nelson. "Understanding the factors affecting the self-heating process of compost piles: Two-dimensional analysis." ANZIAM Journal 63 (June 6, 2022): C15—C29. http://dx.doi.org/10.21914/anziamj.v63.17119.
Full textAbstract:
Industrial compost piles contain large volumes of bulk organic materials. Normally, there are two main heat generation processes—oxidation of cellulosic materials and biological activity within the compost pile. Biological heating occurs at a lower temperature range, but it may `kick-start' the oxidation reaction. Nevertheless, biological heating is desirable and is a key component in composting operations. However, there are cases when the temperature within the compost piles increases beyond the ignition temperature of cellulosic materials which can result in spontaneous ignition. This investigation considers the self-heating process that occurs in a compost pile using a two-dimensional spatially-dependent model incorporating terms that account for self-heating due to both biological and oxidative mechanisms. The variation of temperature distribution within different pile geometries is examined. References P. C. Bowes. Self heating: evaluating and controlling the hazard. Amsterdam: Elsevier Press, 1984 W. F. Brinton, Jr. E. Evans, M. L. Droffner, and R. B. Brinton. Standardized test for evaluation of compost self-heating. BioCycle 36 (1995), pp. 60–65 M. Escudey, A. Arias, J. Forster, N. Moraga, C. Zambra, and A. C. Chang. Sewage sludge self-heating and spontaneous combustion. Field, laboratory and numerical studies. High Temp. Mater. Proc. 27.5 (2008), pp. 337–346. doi: 10.1515/HTMP.2008.27.5.337 R. T. Haug. The Practical Handbook of Compost Engineering. USA: Lewis Publishers, 1993. doi: 10.1201/9780203736234 W. Hogland, T. Bramryd, and I. Persson. Physical, biological and chemical effects of unsorted fractions of industrial solid waste in waste fuel storage. Waste Manage. Res. 14.2 (1996), pp. 197–210. doi: 10.1006/wmre.1996.0019 P. F. Hudak. Spontaneous combustion of shale spoils at sanitary landfill. Waste Manage. Res. 22.6 (2002), pp. 687–688. doi: 10.1016/s0956-053x(01)00077-0 F. Kuwahara, Y. Sano, A. Nakayama, K. Nakasaki, and T. Fukazawa. Numerical modelling of a composting process with aeration. J. Porous Media 12.10 (2009), pp. 927–938. doi: 10.1615/JPorMedia.v12.i10.10 T. Luangwilai and H. S. Sidhu. Determining critical conditions for two dimensional compost piles with air flow via numerical simulations. Proceedings of the 15th Biennial Computational Techniques and Applications Conference, CTAC-2010. Ed. by W. McLean and A. J. Roberts. Vol. 52. ANZIAM J. 2011, pp. C463–C481. doi: 10.21914/anziamj.v52i0.3753 T. Luangwilai, H. S. Sidhu, and M. I. Nelson. A two dimensional, reaction-diffusion model of compost piles. Proceedings of the 10th Biennial Engineering Mathematics and Applications Conference, EMAC-2011. Ed. by M. Nelson, M. Coupland, H. Sidhu, T. Hamilton, and A. J. Roberts. Vol. 53. ANZIAM J. 2012, pp. C34–C52. doi: 10.21914/anziamj.v53i0.5083 T. Luangwilai, H. S. Sidhu, and M. I. Nelson. One-dimensional spatial model for self-heating in compost piles: Investigating effects of moisture and air flow. Food Bioprod. Process. 108 (2018), pp. 18–26. doi: 10.1016/j.fbp.2017.12.001 T. Luangwilai, H. S. Sidhu, and M. I. Nelson. Understanding effects of ambient humidity on self-heating of compost piles. CHEMECA 2018. Institution of Chemical Engineers. 2018, p. 68. url: https://search.informit.org/doi/10.3316/informit.049196748938234 T. Luangwilai, H. S. Sidhu, and M. I. Nelson. Understanding the role of moisture in the self-heating process of compost piles. CHEMECA 2012. Engineers Australia. 2012, pp. 1834–1846. url: https://search.informit.org/doi/10.3316/INFORMIT.867764346204981 T. Luangwilai, H. S. Sidhu, M. I. Nelson, and X. D. Chen. Biological self-heating of compost piles with airflow. CHEMECA 2009. Engineers Australia. 2009, pp. 2683–2692. url: https://search.informit.org/doi/10.3316/informit.799299549211365 T. Luangwilai, H. S. Sidhu, M. I. Nelson, and X. D. Chen. Modelling air flow and ambient temperature effects on the biological self-heating of compost piles. Asia-Pacific J. Chem. Eng. 5.4 (2010), pp. 609–618. doi: 10.1002/apj.438 T. Luangwilai, H. S. Sidhu, M. I. Nelson, and X. D. Chen. Modelling the effects of air flow, ambient temperature and radiative boundary conditions in compost piles. CHEMECA 2010. Engineers Australia. 2010, pp. 3585–3596. url: https://search.informit.org/doi/10.3316/informit.484992904303574 T. Luangwilai, H. S. Sidhu, M. I. Nelson, and X. D. Chen. Modelling the effects of moisture content in compost piles. CHEMECA 2011. Engineers Australia. 2011, pp. 1473–1484. url: https://search.informit.org/doi/10.3316/informit.174710980721893 T. Luangwilai, S. D. Watt, S. Fu, H. S. Sidhu, and M. I. Nelson. Modelling the effects of ambient temperature variation on self-heating process of compost piles. Engineers Australia (2019), pp. 84–96. url: https://search.informit.org/doi/10.3316/informit.689351109484953 N. O. Moraga, F. Corvalan, M. Escudey, A. Arias, and C. E. Zambra. Unsteady 2D coupled heat and mass transfer in porous media with biological and chemical heat generations. Int. J. Heat Mass Trans. 52 (2009), pp. 5841–5848. doi: 10.1016/j.ijheatmasstransfer.2009.07.027 PDE Solutions Inc. FlexPDE v 6.05. PDE Solutions Inc. Cambridge MA, 2009. url: http://www.pdesolutions.com R. Rynk. Fires at composting facilities: causes and conditions Part I. BioCycle 41.1 (2000), pp. 54–58 H. S. Sidhu, M. I. Nelson, and X. D. Chen. A simple spatial model for self-heating compost piles. Proceedings of the 13th Biennial Computational Techniques and Applications Conference, CTAC-2006. Ed. by W. Read and A. J. Roberts. Vol. 48. ANZIAM J. 2007, pp. C135–C150. doi: 10.21914/anziamj.v48i0.86
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Lapeira, María. "Éxito y habilidades/ competencias y liderazgo." Perfiles Gerenciales. Gestión Social y Solidaria 6, no. 1 (April 3, 2017): 25–27. http://dx.doi.org/10.18041/2389-9697/per_ger_gestion.1.2017.4575.
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Mi nombre es Nelson Remolina, yo soy profesor de la Universidad de los Andes ya hace dieciséis años, profesor de planta tiempo completo, actualmente dirijo un grupo de estudios en temas de internet, comercio e l e c t r ó n i c o , t e l e c o m u n i c a c i o n e s e Informática (GECTI). Un observatorio de protección de datos y dirijo la Especialización en Derecho Comercial y soy profesor de planta e investigador.
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Evans, David. "Functional Behavioral Assessment: An Interactive Training Module C. Liaupsin, T. Scott, & C. Nelson Sopris West." Australasian Journal of Special Education 25, no. 1-2 (2001): 86–87. http://dx.doi.org/10.1017/s1030011200024878.
Full textDissertations / Theses on the topic "C.T. Nelson Co"
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Burke, Stephanie. "Generalized Impairment of CD8+ T-cells in HCV Mono- and HIV-HCV Co-infection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32770.
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Chronic hepatitis C virus (HCV) infection has global effects on the immune system. CD8+ T-cells, responsible for viral clearance and control, are dysfunctional for as yet unknown reasons. It is hypothesized that IL-7 signaling pathway deficiencies contribute to this impairment. Blood-derived CD8+ T-cells in chronic HCV mono- and HIV-HCV co-infection had lower IL-7-induced activation of STAT5 and production of Bcl-2, and lower proliferation in co-infection, compared to controls. Lower Bcl-2 production was also associated with increased fibrosis. These changes were independent of the IL-7 receptor α expression and suppressor of cytokine signaling 1 or 3 expression. Intrahepatic CD8+ T-cells in HCV-infection did not activate STAT5 above basal levels with cytokine stimulation and had lower Bcl-2 expression than blood-derived cells. In conclusion, bulk CD8+ T-cells were impaired in response to IL-7 and the IL-7 signaling pathway may be one mechanism by which CD8+ T-cells are impaired in chronic HCV infection.
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Li, Jasmine. "Nuclear protein Kinase C-theta and permissive Chromatin states co-ordinate transcriptional memory responses in human T cells." Phd thesis, Canberra, ACT : The Australian National University, 2014. http://hdl.handle.net/1885/150132.
Full textAbstract:
Memory T cells have the selective ability to up-regulate gene transcription much more rapidly and at higher levels than naive T cells. Histone modifications are known to provide permissive Chromatin structure that facilitates this process of transcriptional memory. Protein Kinase C (PKC) family members have recently emerged as a new class of enzymes that function as both cytoplasmic signalling kinases and chromatin-modifiers that regulate gene transcription. PKC-theta is predominately expressed in T cells but not in B cells and it plays an integral part in the T cell immunological synapse, which leads to the activation of Activator Protein-1 (AP-1), Nuclear Factor of Activated T cells (NFAT) and Nuclear Factor-kappaB (NF-KB) for the expression of immune responsive genes. Its importance has also been demonstrated previously in antigen recalling responses in memory T cells. At the level of chromatin regulation, PKC-theta has been shown to be essential in mediating the formation of an active transcription complex for IL2 gene expression, a gene known to have transcriptional memory response. To determine the role of PKC-theta in the establishment of transcriptional memory, an in vitro Jurkat T cell model was developed. Whole-transcriptome microarray expression analysis of this model identified groups of genes with shared characteristic transcriptional responses to repeated stimulation, namely transcriptional memory responsive, primary-specific responsive, secondary-specific responsive and stimulation compliant genes. These gene cohorts could be distinguished on the basis of the number of consensus motifs shared across their gene promoters, with transcriptional memory responsive and secondary-specific responsive genes being the richest in transcription factor binding sites compared to the other groups. Genome-wide ChIP-sequencing of the cytoplasmic-nuclear signalling kinase, PKC-theta in ex vivo derived T cells showed that it was significantly enriched in the chromatin of effector and activated memory CD4+ T cells compared to naive T cells. The knockdown of PKC-theta impaired the expression of genes with a transcriptional memory response but not the Activation Compliant genes in ex vivo derived activated memory CD4+ T cells. Gene-specific ChIP-PCR demonstrated the recruitment of PKC-theta to promoters of actively transcribed genes in Jurkat T cells during both primary and secondary activation. In the ex vivo derived naive and memory T cells, a consistent level of PKC-theta enrichment was detected at the promoter of CD69, a transcriptional memory non-responsive gene but rapid IL2 transcriptional response was associated with a gene-specific increase of nuclear PKC-theta at its proximal promoter in activated memory CD4+ T cells. Furthermore, nuclear PKC-theta was recruited to a regions with a permissive chromatin state, defined by high levels of the activating marks, H3K4me3 and H3K9ac and low levels of the repressive mark, H3K27me3. ChIP-PCR analysis of the IL2 promoter also revealed enrichment of the histone demethylase LSD1 in these cells. Collectively, these results indicate that chromatin-tethered PKC-theta forms a part of the permissive chromatin state that co-ordinates rapid transcriptional programs in memory T cells.
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Barbosa, Cleonilson Mafra. "S?ntese e caracteriza??o de eletrocatalisadores mistos de ni?bio e t?ntalo dopados com Co, Cu e Ni a partir da columbita/tantalita." PROGRAMA DE P?S-GRADUA??O EM CI?NCIA E ENGENHARIA DE MATERIAIS, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/24350.
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Esse trabalho prop?s uma rota alternativa de s?ntese de catalisadores para rea??es de oxida??o do metanol e etanol a serem aplicados em c?lulas a combust?vel, sendo estes a base de ?xidos e precursores mistos de ni?bio e t?ntalo puros e dopados com cobalto, cobre e n?quel, obtidos a partir do mineral de base, a columbita/tantalita. Inicialmente, foi efetivado um planejamento experimental da purifica??o total deste min?rio, na sequ?ncia, foi realizada a dopagem usando um percentual de 10%, em massa. Os tratamentos t?rmicos foram realizados em tr?s diferentes temperaturas (110, 400 e 600 ?C). Na sequ?ncia, foi efetivada a s?ntese do precursor oxalato, que foi utilizado, por conseguinte, na s?ntese dos precursores dopados onde estes passaram pelos mesmos procedimentos dos ?xidos. O min?rio puro e tratado foi caracterizado por fluoresc?ncia de raios X (FRX) e difra??o de raios X (DRX) que mostraram a sua total purifica??o. O precursor foi avaliado atrav?s das an?lises de difra??o de raios X (DRX), espectroscopia de infravermelho (IV), an?lises t?rmicas (TG/DTG/DSC e DTA) e a microscopia eletr?nica de varredura (MEV); apresentando part?culas inferiores a 0,2 micrometros, um alto valor de perda de massa (76,6 %) e uma estrutura porosa de formas irregulares. Os catalisadores puros e dopados foram submetidos ?s an?lises por difra??o de raios X (DRX), espectroscopia de fotoel?trons excitados por raios X (XPS), microscopia eletr?nica de varredura (MEV) e microscopia eletr?nica de transmiss?o (MET), que apresentaram fortes ind?cios de propriedades catal?ticas para a oxida??o devido a sua r?pida redu??o. Na caracteriza??o el?trica, estes catalisadores foram avaliados pela t?cnica da voltametria de pulso diferencial (DPV) atrav?s de sensores em rea??o para a oxida??o dos ?lcoois. As an?lises demonstraram que estes materiais s?o ?timos condutores, porque aumentaram a passagem de corrente el?trica do eletrodo de trabalho em at? duas ordens de grandeza superior ao eletrodo de ouro. Os melhores desempenhos para as rea??es foram observados principalmente com o dopante de cobre, seguido por o n?quel, o puro e depois o de cobalto, considerando ainda que os materiais obtidos possuem caracter?sticas apropriadas para aplica??o em eletrodos de c?lulas a combust?vel.
This paper proposes an alternative route for producing catalysts for methanol and ethanol oxidation reactions to be applied on fuel cells. Those catalysts are based on oxides and precursors of mixed niobium and tantalum materials in their pure and doped (with Co, Cu or Ni) forms. These materials are obtained from columbite/tantalite, which is the base mineral for Nb, Ta. At first, an experimental planning for the complete purification of the mineral was performed. After purification, 10%wt. doping with each of the metals, and thermal treatment at three different temperatures (110,400 and 600?C) was carried out. Un-doped purified oxides were then subject to complexation process followed by metal addition (doping) and thermal treatment. Purified and thermally treated mineral was characterized by X-Ray Fluorescence (XRF) and X-Ray Diffraction and complete purification was attained. Complex precursors were evaluated on the basis of XRD, Infra-Red Spectroscopy (IR), thermal behavior (TG/DSC and DTA) and morphology (Scanning Electron Microscopy) and presented particle sizes under 0.2 ?m, elevated weight loss (76.6%) and a porous structure of irregular shape. Pure and doped catalysts were characterized on XRD, XPS (X-Ray Excited Photon Spectroscopy), SEM and TEM (Transmission Electron Microscopy) basis, presenting indication of catalytic properties interesting for oxidation reactions, such as quick surface reduction. Electrical evaluation of the catalysts was performed according to Differentia Pulse Voltammetry (DPV) with the use of micro sensors during alcohol oxidation reactions. These analyses indicated the excellent conducting characteristics of the materials as electric current flow was increased in two orders of magnitudes in comparison to gold electrodes. The best catalytic behaviors were observed when dopping was performed with copper, followed by nickel, without and cobalt dopant addition. Therefore, the synthesized materials presented characteristics that indicate their suitability for use as fuel cells electrodes.
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Auma, Ann Winniefred Nangobi. "THE IMPACT OF DIRECT-ACTING ANTI-VIRAL THERAPY ON NAIVE CD4+ T CELL LYMPHOPENIA AND CELLULAR IMMUNE ACTIVATION IN HCV INFECTION AND HCV/HIV CO-INFECTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625764728651756.
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Saes, Sueli Gonsalez. "Aplicação de métodos bibliométricos e da \"Co-Word Analysis\" na avaliação da literatura científica brasileira em ciências da saúde de 1990 a 2002." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-13112007-180403/.
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Analisou-se neste trabalho a produção científica brasileira, no campo da Saúde, por meio da pesquisa de publicações, constantes da base de dados \"Web of Knowledge\", no período de 1990 a 2002. A pesquisa incluiu 3.066 revistas desse campo do conhecimento. Nesse período foram contabilizadas 38.349 publicações. Os métodos bibliométricos tradicionais e a \"co-word analysis\" foram utilizados como instrumento de análise para medir a atividade científica no campo da saúde. O pacote estatístico, Statistical Package for Social Science - SPSS, foi utilizado para a obtenção dos indicadores bibliométricos tradicionais. Demonstraram-se as etapas de trabalho e a potencialidade da \"co-word analysis\". Foram estudadas as palavras que representam os descritores e identificadores na base de dados e estas foram relacionadas com outras variáveis como autores, ano de publicação e filiação da publicação. Para tal, utilizou-se o \"Tétralogie\", um software que aplica tratamentos estatísticos para conseguir que o grau de co-ocorrência entre as palavras seja representado como distâncias no espaço. Desta forma, as palavras podem ser visualizadas como pontos no espaço, por meio dos mapas tecnológicos e a distância entre elas será representativa de sua co-ocorrência ou afinidade. Os mapas tecnológicos permitiram a identificação de redes de cooperação entre pesquisadores e instituições, bem como identificação de \"clusters\" entre autores e as palavras descritoras do campo de conhecimento estudado. Esta abordagem para a área de avaliação em Ciência e Tecnologia demonstrou ampliar as análises bibliométricas tradicionais, e pode incrementar as atividades de planejamento e definição de ações estratégicas indicando, para onde e como se poderiam dirigir esforços para desenvolvimento do campo estudado.This work analyzed Brazilian scientific production in the health sciences field by analysis of publications present in the database \"Web of knowledge\" in the period from 1990 to 2002. The study covered 3,066 journals in this field of knowledge. During this period a total of 38,349 Brazilian publications were found. Bibliometric analysis and \"co-word analysis\" were used to measure the scientific activity in health sciences. A statistical software package (Statistical Package for Social Science SPSS) was used to determine traditional bibliometric analysis. The words representing descriptors and identifiers in the database had been studied and the relationship to other variables such as authors, publication year, and affiliation within the publication was determined. For this analysis, the \"Tétralogie\" software that applies statistical methods to measure the co-occurrence among words and represents this measure as distances in space was used. In this way, words can be visualized as points in space on a map. The maps and distances between words will represent the co-occurrence or affinity between keywords. The technological maps have shown networks of cooperation among researchers and institutions, as well as identification of \"clusters\" of authors and a hierarchy of the descriptive keywords. This approach for evaluation of science and technology demonstrated an extension of the traditional bibliometric analysis and showed that it could improve planning activities by identification of strategic actions pointing to where and how efforts for improvement in the field of health sciences should be directed.
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Slatculescu, Andreea M. "Immune Dysfunction Associated with Hemodialysis Modalities." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30493.
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Infection is a leading cause of death in hemodialysis patients, partly due to dysfunctional immunity. Frequent dialysis therapy improves patient outcomes and quality of life. We hypothesize that extended home hemodialysis (EHHD) also improves immune function compared to conventional in-hospital hemodialysis (CHD); therefore, we designed a prospective matching-cohort clinical study to assess serum inflammatory markers and the functional capacity of monocyte-derived dendritic cells (MDDCs) and T-lymphocytes. Serum CRP was decreased in EHHD patients suggesting that extended dialysis may decrease inflammatory solute/cytokine levels. Compared to controls, MDDCs from hemodialysis patients had similar endocytic capacity, expression of co-stimulatory molecules, and T-cell activation capacity. However, CHD was associated with the highest expression of CD83 and CD40. Activated T-cells in CHD patients also produced significantly more immunosuppressive IL-10 compared to EHHD patients and controls. Therefore, EHHD may improve immune function by decreasing inflammation, MDDC pre-activation, and synthesis of immunosuppressive cytokines.
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Domingos, Estela Maria Almeida. "Os desafios das tecnologias da informação e telecomunicações (TIT) nos países em desenvolvimento : o caso de Moçambique." Master's thesis, Instituto Superior de Economia e Gestão, 1997. http://hdl.handle.net/10400.5/15996.
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Mestrado em Desenvolvimento e Cooperação InternacionalAs Tecnologias da Informação e Telecomunicações (TIT) constituem um dos motores da mudança de paradigma tecno-económico, delineada desde o princípio da década de oitenta, na medida em que facilitam os processos de acesso à informação e de criação de conhecimento e possuem um carácter penetrante sobre o conjunto das actividades económicas e sociais. Numa economia cada vez mais global, onde as distâncias geográficas diminuem e os recursos de capital e humanos circulam cada vez mais livremente, a inovação surge como a principal fonte de vantagem competitiva ao permitir produzir a custos inferiores ou de forma diferenciada. O desenvolvimento económico e social dos países depende, assim, cada vez mais da existência de capacidades endógenas ao nível da ciência & tecnologia e de recursos humanos qualificados. A partir de um quadro teórico Neo-Schumpeteriano de análise da mudança tecnológica, o presente trabalho procura identificar e caracterizar os desafios que se colocam aos Países em Desenvolvimento na transição para a nova «Sociedade de Informação», na medida em que a revolução tecno-económica em curso cria, a par de uma ameaça acrescida de periferização, «janelas de oportunidades» que, adequadamente aproveitadas, poderão possibilitar um «salto» no seu processo de desenvolvimento. É realizado um estudo de caso sobre Moçambique onde se analisa a evolução recente da política de desenvolvimento económico e social e a relevância das TIT para a consolidação deste processo inserida num quadro de cooperação internacional e regional para o desenvolvimento.
The Information Technologies and Telecommunications (ITT) are one of the engines in the change of the techno-economic paradigm, drew since the beginning of the eighties, in the extent they facilitate the information access and knowledge creation processes and they have a diffusive character under the social and economic activities. In a increasingly global economy, vvhere the geographical distances decreases and the human and capital resources flovvs more freely, the innovation comes-up as the main competitive advantage source since it allows lovver costs or differentiated production. The social and economic development depends increasingly in the existence of endogenous capabilities in science & technology and qualified human resources. Under a Neo-Schumpeterian technological change theoretical analysis, this work searchs to identify and characterise the challenges placed to the developing countries in the «Information Society» transition, as far as the current techno-economic revolution creates, abreast to an increased exclusion threat, «vvindows of opportunity» which properly taken make possible a «leap» in their developing process. A Mozambique case study is accomplished vvhere the recent social and economic development policy evolution and the ITT relevance to this process consolidation is analysed in an intemational and regional co-operation framework to development.
info:eu-repo/semantics/publishedVersion
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Shiuh-Jang, Pan, and 潘旭璋. "A Study on Upgrade and Innovation Models of Taiwan Traditional Industries－A Case of T Y C Brother Industrial Co.,Ltd. in the." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/96611443485503867097.
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碩士立德管理學院
科技管理研究所
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「Innovation」argument was pointed out by Schumpeter in 1928.Untill the middle of the 1990s due to the science and technology industries to be developed. From that on, there had a scholar and an organization studying and conferring to innovate theory to go a further step. At present, it has already become to science and technology management is major for studying or discussing. T.Y.C was established in 1986 .In several short decades immediate development has became the lu of our lamp industry .Strengthly grow up is surprising.Also to occupy automobile parts gross export value`s specific weight reaching 6.5% .That one`s in process of innovate would be effected . Whether is different from a business innovate effectiveness criticial factor and innovation management model is very to be worth study case.In this study use demonstrate to test and verify study assume.Throught proceed earnest interview to demonstrate study to obtain conclusion： 1. In innovation process enterprise Resource and Competence are business long-tern strategics and organization to earn profits.In this study believe automobile parts factory to hold grown up the best Model which was built advantage resource of the core. 2. innovation process can not apart from strategics management. In study result found：innovation process and strategics management Influenced each another.can not recognize which is a factor or effects. 3. Product、Market channel strategics et can create business profits but decided by innovation strategics： In study result found in different time spot different innovation can create different career the high capability and high profits.
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Jalbert, Émilie. "Étude des réponses immunitaires humorales et cellulaires dirigées contre la protéine F du virus de l'hépatite C." Thèse, 2005. http://hdl.handle.net/1866/15149.
Full textBooks on the topic "C.T. Nelson Co"
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Bach, Va n. S~i. Vie t-Nam: Se la quo c gia ©ʻa u tie n co che ©ʻo thuc su trung-la p. Illinois: [Bach Va n S~i?], 1987.
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Johnston, Richard, Mike Longworth, and Dick Boak. C. T. Martin and Co. Rowman & Littlefield Publishers, Incorporated, 2009.
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Court, U. S. Supreme. U.S. Supreme Court Transcript of Record Houston & T C R Co v. Smith. Gale, U.S. Supreme Court Records, 2011.
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F T C V Ruberoid Co US Supreme Court Transcript of Record with Supporting Pleadings. Gale, U.S. Supreme Court Records, 2011.
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PECK, DAVID W. F. T. C. v. Mary Carter Paint Co. U.S. Supreme Court Transcript of Record with Supporting Pleadings. Gale, U.S. Supreme Court Records, 2011.
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FLOBERG, JOHN F. Firestone Tire & Rubber Co v. F T C U.S. Supreme Court Transcript of Record with Supporting Pleadings. Gale, U.S. Supreme Court Records, 2011.
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P T Johnston & Co. Victoria Nursery and Seed Establishment, Price List for 1878 of Agricultural, Garden and Flower Seeds, Horticultural Requisites, &C. [microform]: For Sale by P. T. Johnston & Co. , Successors to Mitchell and Johnston, Nurserymen, Seedsmen and Florists, ... Creative Media Partners, LLC, 2021.
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Nominations before the Senate Armed Services Committee, second session, 109th Congress: Hearings before the Committee on Armed Services, United States Senate, One Hundred Ninth Congress, second session, on nominations of Hon. Preston M. Geren; Hon. Michael L. Dominguez; James I. Finley; Thomas P. D'Agostino; Charles E. McQueary; Anita K. Blair; Benedict S. Cohen; Frank R. Jimenez; David H. Laufman; Sue C. Payton; William H. Tobey; Robert L. Wilkie; Lt. Gen. James T. Conway, USMC; Gen. Bantz J. Craddock, USA; Vadm. James G. Stavridis, USN; Nelson M. Ford; Ronald J. James; Scott W. Stucky; Margaret A. Ryan; and Robert M. Gates, February 15, July 18, 27, September 19, December 4, 5, 2006. Washington: U.S. G.P.O., 2007.
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Choo, Andrew L.-T. Evidence. 6th ed. Oxford University Press, 2021. http://dx.doi.org/10.1093/he/9780198864172.001.0001.
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Andrew Choo’s Evidence provides an account of the core principles of the law of civil and criminal evidence in England and Wales. It also explores the fundamental rationales that underlie the law as a whole. The text explores current debates and draws on different jurisdictions to achieve a mix of critical and thought-provoking analysis. Where appropriate the text draws on comparative material and a variety of socio-legal, empirical, and non-legal material. This (sixth) edition takes account of revisions to the Criminal Procedure Rules, the Criminal Practice Directions, and the Police and Criminal Evidence Act Codes of Practice. It also examines in detail cases on various topics decided since the last edition was completed, or the significance of which has become clear since then, including: • Addlesee v Dentons Europe llp (CA, 2019) (legal professional privilege) • Birmingham City Council v Jones (CA, 2018) (standard of proof) • R v B (E) (CA, 2017) (good character evidence) • R v Brown (Nico) (CA, 2019) (hearsay evidence) • R v C (CA, 2019) (hearsay evidence) • R v Chauhan (CA, 2019) (submissions of ‘no case to answer’) • R v Gabbai (Edward) (CA, 2019) (bad character evidence) • R v Gillings (Keith) (CA, 2019) (bad character evidence) • R v Hampson (Philip) (CA, 2018) (special measures directions) • R v K (M) (CA, 2018) (burden of proof) • R v Kiziltan (CA, 2017) (hearsay evidence) • R v L (T) (CA, 2018) (entrapment) • R v Reynolds (CA, 2019) (summing-up) • R v S (CA, 2016) (hearsay evidence) • R v SJ (CA, 2019) (expert evidence) • R v Smith (Alec) (CA, 2020) (hearsay evidence) • R v Stevens (Jack) (CA, 2020) (presumptions) • R v Townsend (CA, 2020) (expert evidence) • R v Twigg (CA, 2019) (improperly obtained evidence) • R (Jet2.com Ltd) v CAA (CA, 2020) (legal professional privilege) • R (Maughan) v Oxfordshire Senior Coroner (SC, 2020) (standard of proof) • Serious Fraud Office v Eurasian Natural Resources Corpn Ltd (CA, 2018) (legal professional privilege) • Shagang Shipping Co Ltd v HNA Group Co Ltd (SC, 2020) (foundational concepts; improperly obtained evidence) • Stubbs v The Queen (PC, 2020) (identification evidence) • Volaw Trust and Corporate Services Ltd v Office of the Comptroller of Taxes (PC, 2019) (privilege against self-incrimination) • Volcafe Ltd v Cia Sud Americana de Vapores SA (SC, 2018) (burden of proof)
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Hegland, Frode, ed. The Future of Text. Future Text Publishing, 2020. http://dx.doi.org/10.48197/fot2020a.
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This book is the first anthology of perspectives on the future of text, one of our most important mediums for thinking and communicating, with a Foreword by the co-inventor of the Internet, Vint. Cerf and a Postscript by the founder of the modern Library of Alexandria, Ismail Serageldin. In a time with astounding developments in computer special effects in movies and the emergence of powerful AI, text has developed little beyond spellcheck and blue links. In this work we look at myriads of perspectives to inspire a rich future of text through contributions from academia, the arts, business and technology. We hope you will be as inspired as we are as to the potential power of text truly unleashed. Contributions by Adam Cheyer • Adam Kampff • Alan Kay • Alessio Antonini • Alex Holcombe • Amaranth Borsuk • Amira Hanafi • Amos Paul Kennedy Jr. • Anastasia Salter • Andy Matuschak & Michael Nielsen • Ann Bessemans & María Pérez Mena • Andries Van Dam • Anne-Laure Le Cunff • Anthon Botha • Azlen Ezla • Barbara Beeton • Belinda Barnet • Ben Shneiderman • Bernard Vatant • Bob Frankston • Bob Horn • Bob Stein • Catherine C. Marshall • Charles Bernstein • Chris Gebhardt • Chris Messina • Christian Bök • Christopher Gutteridge • Claus Atzenbeck • Daniel Russel • Danila Medvedev • Danny Snelson • Daveed Benjamin • Dave King • Dave Winer • David De Roure • David Jablonowski • David Johnson • David Lebow • David M. Durant • David Millard • David Owen Norris • David Price • David Weinberger • Dene Grigar • Denise Schmandt-Besserat • Derek Beaulieu • Doc Searls • Don Norman • Douglas Crockford • Duke Crawford • Ed Leahy • Elaine Treharne • Élika Ortega • Esther Dyson • Esther Wojcicki • Ewan Clayton • Fiona Ross • Fred Benenson & Tyler Shoemaker • Galfromdownunder, aka Lynette Chiang • Garrett Stewart • Gyuri Lajos • Harold Thimbleby • Howard Oakley • Howard Rheingold • Ian Cooke • Iian Neil • Jack Park • Jakob Voß • James Baker • James O’Sullivan • Jamie Blustein • Jane Yellowlees Douglas • Jay David Bolter • Jeremy Helm • Jesse Grosjean • Jessica Rubart • Joe Corneli • Joel Swanson • Johanna Drucker • Johannah Rodgers • John Armstrong • John Cayle • John-Paul Davidson • Joris J. van Zundert • Judy Malloy • Kari Kraus & Matthew Kirschenbaum • Katie Baynes • Keith Houston • Keith Martin • Kenny Hemphill • Ken Perlin • Leigh Nash • Leslie Carr • Lesia Tkacz • Leslie Lamport • Livia Polanyi • Lori Emerson • Luc Beaudoin & Daniel Jomphe • Lynette Chiang • Manuela González • Marc-Antoine Parent • Marc Canter • Mark Anderson • Mark Baker • Mark Bernstein • Martin Kemp • Martin Tiefenthaler • Maryanne Wolf • Matt Mullenweg • Michael Joyce • Mike Zender • Naomi S. Baron • Nasser Hussain • Neil Jefferies • Niels Ole Finnemann • Nick Montfort • Panda Mery • Patrick Lichty • Paul Smart • Peter Cho • Peter Flynn • Peter Jenson & Melissa Morocco • Peter J. Wasilko • Phil Gooch • Pip Willcox • Rafael Nepô • Raine Revere • Richard A. Carter • Richard Price • Richard Saul Wurman • Rollo Carpenter • Sage Jenson & Kit Kuksenok • Shane Gibson • Simon J. Buckingham Shum • Sam Brooker • Sarah Walton • Scott Rettberg • Sofie Beier • Sonja Knecht • Stephan Kreutzer • Stephanie Strickland • Stephen Lekson • Stevan Harnad • Steve Newcomb • Stuart Moulthrop • Ted Nelson • Teodora Petkova • Tiago Forte • Timothy Donaldson • Tim Ingold • Timur Schukin & Irina Antonova • Todd A. Carpenter • Tom Butler-Bowdon • Tom Standage • Tor Nørretranders • Valentina Moressa • Ward Cunningham • Dame Wendy Hall • Zuzana Husárová. Student Competition Winner Niko A. Grupen, and competition runner ups Catherine Brislane, Corrie Kim, Mesut Yilmaz, Elizabeth Train-Brown, Thomas John Moore, Zakaria Aden, Yahye Aden, Ibrahim Yahie, Arushi Jain, Shuby Deshpande, Aishwarya Mudaliar, Finbarr Condon-English, Charlotte Gray, Aditeya Das, Wesley Finck, Jordan Morrison, Duncan Reid, Emma Brodey, Gage Nott, Aditeya Das and Kamil Przespolewski. Edited by Frode Hegland.
Book chapters on the topic "C.T. Nelson Co"
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Baumgärtel, G., and K. H. Bennemann. "Theoretical Study of Oxygen Disorder Effects in YBa2(Cu1−xMx)3O7+y (M = Al, Co, Fe, Ga)." In Oxygen Disorder Effects in High-T c Superconductors, 201–9. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0561-3_17.
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Thom, Jennifer S. "Co/inspiriting Ecological Conversations with Chet A. Bowers (1935–2017) and Ted T. Aoki (1919–2012)." In Curriculum, Environment, and the Work of C. A. Bowers, 22–43. New York: Routledge, 2021. http://dx.doi.org/10.4324/9780367822460-2.
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Liu, Zhuang, Lin Zhu, Hanlin Yang, Jiang Chang, and Wenping Cao. "SiO x /TiO y /C z H t Composite Coatings Prepared by Magnetron Co-sputtering on Substrate Paper." In Lecture Notes in Electrical Engineering, 591–96. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7629-9_72.
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Taber, Douglass F. "New Methods for C-C Bond Construction." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0023.
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Luigino Troisi of the University of Salento found (Tetrahedron Lett. 2010, 51, 371) that a variety of primary and secondary amines could be coupled with a benzylic halide 1 under carbonylating conditions. Ilhyong Ryu of Osaka Prefecture University showed (Organic Lett. 2010, 12, 1548) that under reducing conditions, an iodide 3 coupled with CO to give the primary alcohol. Felicia A. Etzkorn of Virginia Tech observed (Organic Lett. 2010, 12, 696) that under Hg hydrolysis conditions, the orthothioester derived from 5 coupled with 6 to give 7. Yasuharu Yoshimi of the University of Fukui and Minoru Hatanaka of Iwate Medical University devised (Tetrahedron Lett. 2010, 51, 2332) conditions for the decarboxylative addition of the acid 8 to 9 to give 10. Yong-Min Liang and Xiaojun Yao of Lanzhou University and Chao-Jun Li of McGill University described (J. Org. Chem. 2010, 75, 783) a related procedure with α-amino acids. Yasutaka Ishii of Kansai University established (J. Am. Chem. Soc. 2010, 132, 2536) that t -butyl acetate 12 was an effective partner for the Ir-mediated oxidation-coupling-reduction of an alcohol 11. He used (J. Org. Chem. 2010, 75, 1803) a similar protocol to condense acetone with the diol 14, to give the long-chain diketone 16. The formation of allylic Grignard reagents can be inefficient because the excess reactive halide tends to couple with the Grignard reagent as it forms. Brandon L. Ashfeld of the University of Notre Dame found (Tetrahedron Lett. 2010, 51, 2427) a simple solution to this problem: inclusion of a catalytic amount of the inexpensive Cp2 TiCl2 to mediate the addition of 18 to 17. Brian T. Connell of Texas A&M University demonstrated (J. Am. Chem. Soc. 2010, 132, 7826) that with Mn, 21 could be added to 20. The acetate 21 is thus an easily prepared homoenolate equivalent. Note that although 21 is an E/Z mixture, the product 22 is cleanly Z. Gérard Cahiez of the Université de Paris 13 reported (Synlett 2010, 299) a detailed study of the Cu-catalyzed coupling of 24 with 23. Without supporting ligands, slow addition (syringe pump, 1 h) of 24 to 23 assured clean formation of 25. Manual slow addition (dropping funnel, 15 min) was not effective.
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"EMER G ENCE A ND AC CELER AT ION: CO MP UTER-ME D I AT E D CO MMUNI C AT IONA ND T HE CO LLEGE ST UD EN T." In Online Social Networking on Campus, 23–54. Routledge, 2008. http://dx.doi.org/10.4324/9780203884966-3.
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"Co-C Cmoa -n o a -man ma gneamge age enmt ment en otrosrhoasrr sha h in a g ri n o ring ogfopfowf er p ower to m powe tro manage an li angkes links comm cuonm it myuln ea it dyerlsea community leader w de it rhsw go it vhe rn g m ov eenrt nmen s with governm en atg en t c to iaegsemntaocnieaesgneatoblleiennkasb le users/s utsaekresh /s otladkeerhsotlodfeurlsly to efnugla ly g engage in lo users/stakeholders to fu e in local dec caiasglieodnneccmiiessaioknitnomg . eaAnksa in b g le . As." In Water Co-Management, 370. CRC Press, 2013. http://dx.doi.org/10.1201/b14591-36.
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Dumea, Elena, and Simona Claudia Cambrea. "The Influence of Protease Inhibitors on the Evolution of Hepatitis C in Patients with HIV and HCV Co-Infection." In Advances in Hepatology. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96282.
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Prevalence of hepatitis C in HIV infected patients is much higher than in the general population. There is the possibility of viral clearance HCV, in some patients co-infected HIV and HCV, in the phase of immune reconstruction after antiretroviral treatment (ART). There are patients’ anti-HCV positive who initially did not show HCV viral load detected and after the start of ART becomes HCV viral load detectable. There are studies that described that immune restoration with increase in CD4+ and CD8+ T cells, from ART, was important in control of HCV viremia. Has been proposed hypothesis that direct or indirect effect of ART on HCV replication play a role in spontaneous resolution of HCV infection. We evaluated the co-infected patients with HIV and HCV under combined antiretroviral treatment, containing PI boosted with ritonavir in terms of immunological and virological status (for both infection) and also liver disease. Patients were evaluated for liver damage by non-invasive methods. We have shown that a small percentage of patients have severe liver damage. We demonstrated the negative role of HCV on immunological status and in liver fibrosis in co-infected patients. A high proportion of these HIV and HCV co-infected patients had no detectable viremia, higher than other studies published.
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Paley, Morton D. "After-Images: Posthumous Portraits of Coleridge." In Portraits of Coleridge, 109–27. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780198184690.003.0003.
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Abstract IT is frequently the case in our culture that the most important posthumous representations are three-dimensional, and this is certainly true of those of Coleridge, beginning with his death mask or masks and culminating in the commemorative bust sculpted by Hamo Thornycroft for Westminster Abbey. ‘Two casts were taken of S. T. C.’s head after death,’ wrote Henry Nelson Coleridge to John Taylor Coleridge on 7 August 1834. This was unusual, as the normal practice was to take a single mask and then make casts from it. James Gillman supervised the making of the masks, and one of them eventually appeared in the collection of the Edinburgh Phrenological Society, which may already have owned the life-mask taken by Spurzheim. That mask is now in the Henderson Trust Collection, University of Edinburgh. Another death-mask, now in the Princeton University Library, has a curious history.
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Manetta, Emily. "Expanding the typology of Verb Second VPE." In Rethinking Verb Second, 723–44. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198844303.003.0031.
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Mysteriously, Verb Second (V2) languages are known to exhibit auxiliary-stranding verb phrase ellipsis (VPE) but to lack verb-stranding VPE, even though the inflected verb must leave the VP (Mikkelsen 2006; LaCara 2014). Sailor (2018) claims that VPE bleeds V2; the feature that drives ellipsis (on T) is introduced derivationally prior to the feature driving V2 (on C). Only languages with verb movement triggered by T, as in Hebrew (Goldberg 2005), exhibit V-stranding VPE. This chapter offers evidence that Sailor’s approach is on the right track; the Indic language Kashmiri is a V2 language in which auxiliary-stranding and V-stranding VPE co-occur, because T is independently a trigger for V movement (Munshi and Bhatt 2009). The findings support a particular approach to the timing and interaction of the major operations in the grammar and suggest that any approach to V2 must account for the variation in the presentation of VPE in V2 languages.
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Meurig Thomas, John. "Sir Lawrence Bragg at the RI (1953–1966) and the Determination of the First Three-Dimensional Structure of an Enzyme at the DFRL (1965)." In Architects of Structural Biology, 110–34. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198854500.003.0006.
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The transformation in the affairs of the Royal Institution (RI) and the Davy-Faraday Research Laboratory (DFRL) when W. L. Bragg became the new Director there in 1953 is described. He resuscitated the moribund research efforts and injected fresh impetus into the lecture programmes mounted by the RI. In particular, he recruited a powerful team of protein crystallographers (notably D. C. Phillips, A. C. T. North, R. Poljak, Louise Johnson, and C. C. Blake), as well as strong technical backup from instrumental experts like U. Arndt. In the space of a dozen years, this team of co-workers solved the first ever structure of an enzyme, known as lysozyme, which had been discovered by Alexander Fleming in the 1920s. This was a major breakthrough, and it stimulated similar work elsewhere. The chapter also discusses what has happened to the DFRL subsequently. It is now in abeyance, and the reasons for this situation are outlined.
Conference papers on the topic "C.T. Nelson Co"
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Hasan, Md Tanvir, Annika Wolff, and Jari Porras. "Co-designing recycling solutions on campus." In C&T '21: Communities & Technologies 2021. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3461564.3461591.
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Tellioglu, Hilda, Gerfried Mikusch, Christoph Kirchberger, Imre Keseru, Karst T. Geurs, Benjamin Buettner, and Brigitte Vettori. "Co-Creation Practices and Technologies for Open Urban Planning." In C&T '23: The 11th International Conference on Communities and Technologies. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3593743.3593786.
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de Moor, Aldo. "Co-Discovering Common Ground in a Collaborative Community." In C&T 2019: The 9th International Conference on Communities & Technologies - Transforming Communities. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3328320.3328404.
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Samuel, Marly Muudeni. "Co-Production Process with Coastal Communities: Surfacing Ocean Knowledge, Relationships and Culture." In C&T '23: The 11th International Conference on Communities and Technologies. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3593743.3593766.
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Heitlinger, Sara, Rachel Clarke, Adrian K. Clear, Simran Chopra, and Özge Dilaver. "Co-Creating "Smart" Sustainable Food Futures with Urban Food Growers." In C&T 2019: The 9th International Conference on Communities & Technologies - Transforming Communities. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3328320.3328399.
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Leonardi, Chiara, Elena Not, Matteo Gerosa, and Roberta Lotti. "A Case Study of Cross-Organizational Co-Design with Public Bodies: Opportunities for a Collaborative Platform." In C&T '23: The 11th International Conference on Communities and Technologies. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3593743.3593747.
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Muashekele, Chris, Heike Winschiers-Theophilus, and Gereon Koch Kapuire. "Co-Design as a Means of Fostering Appropriation of Conservation Monitoring Technology by Indigenous Communities." In C&T 2019: The 9th International Conference on Communities & Technologies - Transforming Communities. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3328320.3328383.
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Schuchmann, Gabor, and Dora Bachmann. "Impact assessment of cooperative intelligent services on the TEN-T road network of Hungary." In 6th International Conference on Road and Rail Infrastructure. University of Zagreb Faculty of Civil Engineering, 2021. http://dx.doi.org/10.5592/co/cetra.2020.1144.
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Cooperative intelligent transport systems and services (C-ITS) are based on periodical data sharing between cooperative V2X communication units (in-vehicle and roadside units, ITS stations) via a short-range ad-hoc network. All participants are able to acquire information several times per second from others such as position, speed and driving direction as well as intentions and event triggered messages like incidents and emergency braking. Roadside infrastructure can share traffic information like road works or speed limits. As such, C-ITS improves road safety and effectiveness of the transportation system while reduces harmful environmental effects. Transportation authorities and road network operators use cost-benefit analysis to decide on necessary developments. Taking into account only the momentary statistical renewal rate of the vehicle fleet (disregarding all handheld devices), a fully capable operation of such a system can only be predicted in more than 10 years. An overview of existing C-ITS use cases throughout Europe and a simplified comparative analysis of estimated costs and quantifiable benefits of such a system in Hungary is presented in this article. Our research assigned the first developments (i.e. technologies and use cases) in the next 1-3 year period to prepare certain parts of the public road network for CAV testing.
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West, David L., Fred C. Montgomery, and Timothy R. Armstrong. "High-T NOx Sensing Elements Using Conductive Oxides and Pt." In ASME 2004 Internal Combustion Engine Division Fall Technical Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/icef2004-0854.
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Development of NOx sensing elements intended for operation at T ∼600 °C are described. The elements were fabricated by depositing co-planar La1-x Srx BO3 (B = Cr, Fe) and Pt electrodes on yttria-stabilized zirconia substrates. Characterization of the elements included response to NO2 and NO as well as the [O2] dependence of the NO2 response. Much stronger (∼ 40 mV for 450 ppm NO2 in 7 vol% O2 at 600 °C) sensing responses were observed for NO2 than NO, indicating these elements are best suited for detection of NO2. Pronounced asymmetries were observed between the NO2 step response and recovery times for the elements, with temperature being the primary variable governing the recovery times in the temperature range 500–700 °C.
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Fan, Wei, Yu Bai, Yongxia Kang, Lei Zhang, and Benqiang Li. "Phase Stability, Fracture Toughness and Thermal Cycling Behavior of Supersonic Suspension Plasma Sprayed Scandia-Yttria Co-doped Zirconia Thermal Barrier Coatings." In ITSC2018, edited by F. Azarmi, K. Balani, H. Li, T. Eden, K. Shinoda, T. Hussain, F. L. Toma, Y. C. Lau, and J. Veilleux. ASM International, 2018. http://dx.doi.org/10.31399/asm.cp.itsc2018p0100.
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Abstract In this work, one new technique named as supersonic suspension plasma spraying (SSPS) is applied to deposit quasi-columnar scandia-yttria co-doped zirconia (ScYSZ) and yttria-stabilized zirconia (YSZ) thermal barrier coatings (TBCs). The phase composition, microstructural evolution, fracture toughness and failure behavior of both TBCs before and after thermal cycling tests at 1300 °C were systematically studied. It was found that both as-sprayed TBCs were fully non-transformable tetragonal (t’) phase. After the thermal cycling test, tetragonal (t) phase and cubic (c) phase formed for the SSPS-YSZ TBC, while single t’ phase retained for the SSPS-ScYSZ coating. The fracture toughness of the ScYSZ coating was comparable or superior to that of the YSZ coating. As for the thermal cycling behavior, the lifetime of the ScYSZ coating was better than that of the YSZ coating, which confirmed that ScYSZ was a promising alternative material for YSZ.
Reports on the topic "C.T. Nelson Co"
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Wu. Fabrication of High-T(c) Superconducting Infrared Detectors Using Ion-Beam-Assisted Thermal Co-Evaporation. Fort Belvoir, VA: Defense Technical Information Center, May 2002. http://dx.doi.org/10.21236/ada411474.
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Epel, Bernard, and Roger Beachy. Mechanisms of intra- and intercellular targeting and movement of tobacco mosaic virus. United States Department of Agriculture, November 2005. http://dx.doi.org/10.32747/2005.7695874.bard.
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To cause disease, plant viruses must replicate and spread locally and systemically within the host. Cell-to-cell virus spread is mediated by virus-encoded movement proteins (MPs), which modify the structure and function of plasmodesmata (Pd), trans-wall co-axial membranous tunnels that interconnect the cytoplasm of neighboring cells. Tobacco mosaic virus (TMV) employ a single MP for cell- cell spread and for which CP is not required. The PIs, Beachy (USA) and Epel (Israel) and co-workers, developed new tools and approaches for study of the mechanism of spread of TMV that lead to a partial identification and molecular characterization of the cellular machinery involved in the trafficking process. Original research objectives: Based on our data and those of others, we proposed a working model of plant viral spread. Our model stated that MPᵀᴹⱽ, an integral ER membrane protein with its C-terminus exposed to the cytoplasm (Reichel and Beachy, 1998), alters the Pd SEL, causes the Pd cytoplasmic annulus to dilate (Wolf et al., 1989), allowing ER to glide through Pd and that this gliding is cytoskeleton mediated. The model claimed that in absence of MP, the ER in Pd (the desmotubule) is stationary, i.e. does not move through the Pd. Based on this model we designed a series of experiments to test the following questions: -Does MP potentiate ER movement through the Pd? - In the presence of MP, is there communication between adjacent cells via ER lumen? -Does MP potentiate the movement of cytoskeletal elements cell to cell? -Is MP required for cell-to-cell movement of ER membranes between cells in sink tissue? -Is the binding in situ of MP to RNA specific to vRNA sequences or is it nonspecific as measured in vitro? And if specific: -What sequences of RNA are involved in binding to MP? And finally, what host proteins are associated with MP during intracellular targeting to various subcellular targets and what if any post-translational modifications occur to MP, other than phosphorylation (Kawakami et al., 1999)? Major conclusions, solutions and achievements. A new quantitative tool was developed to measure the "coefficient of conductivity" of Pd to cytoplasmic soluble proteins. Employing this tool, we measured changes in Pd conductivity in epidermal cells of sink and source leaves of wild-type and transgenic Nicotiana benthamiana (N. benthamiana) plants expressing MPᵀᴹⱽ incubated both in dark and light and at 16 and 25 ᵒC (Liarzi and Epel, 2005 (appendix 1). To test our model we measured the effect of the presence of MP on cell-to-cell spread of a cytoplasmic fluorescent probe, of two ER intrinsic membrane protein-probes and two ER lumen protein-probes fused to GFP. The effect of a mutant virus that is incapable of cell-to-cell spread on the spread of these probes was also determined. Our data shows that MP reduces SEL for cytoplasmic molecules, dilates the desmotubule allowing cell-cell diffusion of proteins via the desmotubule lumen and reduces the rate of spread of the ER membrane probes. Replicase was shown to enhance cell-cell spread. The data are not in support of the proposed model and have led us to propose a new model for virus cell-cell spread: this model proposes that MP, an integral ER membrane protein, forms a MP:vRNAER complex and that this ER-membrane complex diffuses in the lipid milieu of the ER into the desmotubule (the ER within the Pd), and spreads cell to cell by simple diffusion in the ER/desmotubule membrane; the driving force for spread is the chemical potential gradient between an infected cell and contingent non-infected neighbors. Our data also suggests that the virus replicase has a function in altering the Pd conductivity. Transgenic plant lines that express the MP gene of the Cg tobamovirus fused to YFP under the control the ecdysone receptor and methoxyfenocide ligand were generated by the Beachy group and the expression pattern and the timing and targeting patterns were determined. A vector expressing this MPs was also developed for use by the Epel lab . The transgenic lines are being used to identify and isolate host genes that are required for cell-to-cell movement of TMV/tobamoviruses. This line is now being grown and to be employed in proteomic studies which will commence November 2005. T-DNA insertion mutagenesis is being developed to identify and isolate host genes required for cell-to-cell movement of TMV.