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Dissertations / Theses on the topic 'C-Life'
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Friend, Claire Louise. "Social life of paper in Edinburgh, c.1770-c.1820." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23513.
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Previous research on paper history has tended to be conducted from an economic perspective and/or as part of the field of book history within a broadly literary framework. This has resulted in understandings of paper history being book-centric and focused on production. We now have a great deal of knowledge about the physical process of hand paper-making, a good knowledge of the actors involved and where in the country paper was manufactured, but there is still very little scholarly discussion of the people, processes and practices associated with paper outside of the mill. Taking inspiration from eighteenth-century ‗it-narratives‘, this thesis takes a holistic approach to the paper trade – loosely based around the framework of social life theory as expounded by Arjun Appadurai and Igor Kopytoff. It encompasses a case study of the rag-collection and paper-wholesale operations of a single Edinburgh firm, a wider examination of paper-retailing in Edinburgh, a look at the ownership of desks in Edinburgh alongside a consideration of advice and instruction relating to desk-use, and closes with an examination of the papers owned by a notable Edinburgh family. The first three chapters consider the scope of the Edinburgh paper trade. Moving through distinct stages in the life of paper, these chapters begin with an account of the Edinburgh rag-trade. Business records relating to the Balerno Company‘s rag-buying operations reveal an active and organised network with connections to a variety of trades. Continuing the focus on the Balerno Company, the second chapter considers the company as paper-wholesalers. It demonstrates that the driving force behind their operations was not the supply of paper for the booktrade but rather the provision of wrapping papers for the purposes of commerce. Using advertisements in local newspapers the third chapter looks at the reach of paper-selling beyond the booktrades. The final two chapters move gradually from the commercial to the personal. Chapter four considers the presentation of desk-use in penmanship manuals and the evidence of desk-ownership in confirmation inventories. Both of which are suggestive of a growing mercantile interest in desk furniture. Finally, this thesis closes by looking at the paper archives of the Innes family of Stow in order to examine the extent to which the findings of previous chapters is reflected in the collection, retention and use of papers across two generations of this family. Overall, this thesis demonstrates the value of adopting an inclusive approach to the study of paper history, as doing so opens up a multifaceted world of paper. Paper history has tended to be understood as the history of writing and printing paper sold by booksellers and stationers. The social life approach allows connections to be made between materials, artefacts and trades; to gain a fuller understanding of the role paper played in people‘s lives.
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Cranmer, John Leonard. "Concert life and the music trade in Edinburgh c. 1780-c.1830." Thesis, University of Edinburgh, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508785.
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Boland, Mary Jane. "Constructed identities? : paintings of everyday life in Ireland c.1780 - c.1840." Thesis, University of Nottingham, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659217.
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This thesis examines paintings of everyday life in Ireland from c.1780-c.1840. Primarily, it investigates how the construction of an everyday reality in images by George Grattan, Nathaniel Grogan, John George Mulvany, Joseph Peacock, George Petrie and William Turner de Lond was used as a means to project the identities and ideologies of those that were viewing, buying and commissioning them. Thus, it challenges current perceptions of paintings of everyday life as documents of social history and material culture and instead focuses on how much these images can reveal about the lives of their spectators and patrons. By placing a series of artworks in the social, political and economic contexts in which they were produced, the approach has been an interdisciplinary one and many of the arguments are based on close visual analysis of the images themselves. Comparisons with similar traditions in the art of everyday life in France and Britain, and with the portrayal of Ireland in contemporary novels and travel literature, have also been used as a means to better understand their underlying tone and intent. An important focus is the notion of the everyday itself and what it meant during the period in question. Theoretical texts by Henri Lefebvre, Mikhail Bakhtin and others have been useful in this respect and provide clarification when trying to locate definitions for what the term 'everyday' actually incorporates. It has been revealed that paintings by Grogan, Mulvany and their contemporaries are characterised by a sense of artistic opportunism and variety itself becomes the most dominant structural variant. The patrons of these images are exposed as a diverse group of educated (largely urban) people who were intent on using the everyday aesthetic to propagate their own ideologies of improvement, social order and community pride. Consequently, paintings of everyday life become about projecting the personal, civic and cultural identities that their patrons wanted to be associated with. Ultimately, this thesis provides a significant intervention in the field of both Irish studies and art history because it establishes the everyday as a serious and important aesthetic category in Ireland in the late-eighteenth and nineteenth centuries.
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Springer, Rebecca. "Local religious life in England, c. 1160-1210." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:092a79b0-49e5-4deb-99da-0b282dfaa6da.
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This is a thesis about the ideas and relationships which shaped local religious life, particularly the quotidian religious experiences of ordinary lay people, in late twelfth- century England. Local religious life was not primarily a product of developing ecclesiastical structures, nor of systematic pastoral reform, but rather of ministry relationships, in which one person or group received some kind of religious ministry from another. These relationships were coloured by the beliefs and practical interests of clerical and lay participants. The elite clerical idea of prelacy - in which a prelate, endowed with the burden of pastoral care, spiritually governs subjects - was an old idea which reflected the relationship-based structure of religious life, and which writers adapted in response to local realities. The principal manifestation of this interaction between idea and practice was the claiming of certain lay people as the parishioners of religious houses and local churches: priests and parishioners were analogous, in the minds of ecclesiastics, to prelates and subjects. This grated against the reality that lay people actively shaped their own religious experiences. Local practices, as well as factors such as lordship, geography and association, influenced the ways in which laity and clergy in a given locality thought about their ministry relationships. Lay people in late twelfth-century England were not merely parishioners: they received ministries from the religious, anchorites, saints, and other lay people. This thesis is intended as a corrective to the historiographical field of pastoral care: firstly for a particular historical moment, the second half of the twelfth century in England, but also as a model for future inquiry into other periods and regions. It builds a new conceptual foundation which demands, in turn, a reevaluation of local religious life beyond the late twelfth century and beyond England.
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Gwynne, Paul Gareth. "The life and works of Johannes Michael Nagonius, poeta laureatus c. 1450 - c. 1510." Thesis, University of London, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366500.
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Oakes, Rebecca Holly Anne. "Mortality and life expectancy : Winchester College and New College Oxford c.1393-c.1540." Thesis, University of Winchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504241.
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This thesis contributes new and unique evidence to the debates surrounding population changes in late medieval England. Through the use of documentary evidence it investigates both mortality and life expectancy rates of the students of Winchester College and New College, Oxford, from 1393 - 1540. In so doing it provides the largest single closed population group examined to date for this period and, importantly, the first sample to follow the experiences of children and adolescents. Source materials are analysed, with particular attention paid to their applicability to the study. Research methodology is also considered, in particular database construction and design, essential parts of the manipulation and analysis of such a large dataset. The records of the two colleges are examined in detail, and analyses presented focusing on the admission rates, departure information and mortality rates within each institution. The latter identified changes across the study period and also possible correlations with national disease outbreaks. Analyses of age data for the scholars contribute valuable interpretations of how the two institutions functioned over the course of the study period and how their administrative practices responded to changing mortality patterns and recruitment demands. Life expectancy rates for the scholars are calculated and analysed. Significantly the life expectancy rates of the Winchester sample demonstrate a better experience than that of previously published monastic samples. The Winchester sample follows scholars out into the wider medieval population (post-education), perhaps providing data that is more representative of the wider community than the monastic studies. Interpretations support the hypothesis that underlying mortality patterns were the cause of changes in life expectancy, and that these patterns were likely to be observed across the population. The conclusions from this large and original dataset are placed within the context of the wider historiographical debates. The need for new, relevant and more diverse samples is emphasised to advance the interpretations of population changes and the economic and social history of late medieval England.
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Madden, Andrea V. B. "Henrietta C. Mears, 1890-1963 her life and influence /." Theological Research Exchange Network (TREN), 1997. http://www.tren.com.
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Mitchell, Mark S. "A faithful steward the life of Ray C. Stedman /." Online full text .pdf document, available to Fuller patrons only, 2003. http://www.tren.com.
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Das, Binodini. "Socio-economic life of Orissa : C. A. D. 400-1200 /." Kolkata : R. N. Bhattacharya, 2005. http://catalogue.bnf.fr/ark:/12148/cb41001435m.
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Habsburg, Max von. "The devotional life : Catholic and Protestant translations of Thomas à Kempis' 'Imitatio Christi', c.1420-c.1620." Thesis, University of St Andrews, 2002. http://hdl.handle.net/10023/2696.
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The incorporation of the Imitatio by Protestant and Catholic reform movements suggests important points of continuity between late medieval and early modem religion, especially within the realm of spirituality. The study of the Imitatio is testimony to the versatility of spirituality; it was accessible both to the laity and monks and also to Protestants and Catholics. The ethical emphasis of the Imitatio, its interiority, its simplicity and intended renewal in Christ, were vital to its endurance. The text's accessibility was reinforced by the expansive nature of late medieval and early modem translations. English and French translations of the Imitatio at the turn of the sixteenth century reflected the concern for simplification, thereby simplifying the text rather than providing an alternative interpretation. In the sixteenth century, Protestant translators, grounded in the essential tenets of Lutheran theology, inevitably revised or removed any explicitly Catholic elements of the Imitatio's spirituality. Despite its apparent widespread appeal, the promotion of the Imitatio tended to be undertaken by late medieval and early modem movements which had links with the devotio moderna. The Imitatio was circulated in late medieval England and France by individuals whose connections with the devotio moderna were marked. Indeed, a similar trend was evident with the Protestant tradition of the text; Leo Jud, Caspar Schwenckfeld and Sebastian Castellio were all directly or indirectly influenced by the Brethren. Most striking of all was the timing with which translations of the Imitatio appeared. The translations by Caspar Schwenckfeld, Leo Jud, Edward Hake and Thomas Rogers were undertaken at a critical stage of their respective Reformations. Similarly, the Jesuits, traditionally viewed as the vanguards of the Counter- Reformation, were deeply committed to the Imitatio. Devotional works were vital to the maturing progress of Reformations, regardless of the confession. Spirituality was not a peripheral, insignificant dimension of religion; it remained at the very centre of Protestant and Catholic self-perception and identity.
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McCluskey, Raymond. "The life and works of Martin of Leon (c. 1130-1203)." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304862.
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Duff, Jonathan B. "A service life analysis of U.S. Coast Guard C-130 aircraft." View report, 2003. http://handle.dtic.mil/100.2/ADA413132.
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Thesis (M.S.)--Air Force Institute of Technology, 2003.Title from title screen (viewed May 10, 2004). "March 2003." Vita. "AFIT/GAQ/ENS/03-02." "ADA413132"--URL. Includes bibliographical references (leaves 132-135). Also issued in paper format.
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King, Kevin V. "Signaling components in development and life span determination in C. elegans /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9901251.
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Quick, T. R. "Techniques of Life : zoology, psychology and technical subjectivity (c.1820-1890)." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1336074/.
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This thesis associates the cultural elevation of discourse articulating physiologically-centred conceptions of self in mid-nineteenth-century Britain with a shift in power relations. I contend that the proliferation of zoologically- and neurologically-oriented texts, themselves embodying politics of natural truth, constituted a condition of possibility for the emergence of what I portray as a 'technicalization' of power. The articulation of organically determined notions of subjectivity are associated with the constitution of a technical ideal of knowledge production. Further, technical assemblages upon which physiological conceptions of self relied are shown to have helped constitute modes of resistance to discourse concerned with the organic determination of mind and life. Technical entities played an active role in the constitution of organic subjectivities, and organic subjectivities in turn participated in the constitution of technical modes of being. The historical narrative represents the formation of two related disciplines, zoology and psychology, as contingent upon the relative status of different kinds of epistemic equipment. In a natural philosophic context pervaded by uncertainty regarding the relation of matter to spirit, claims that could be made regarding nature were circumscribed by what 'gentlemanly' equals could agree to have 'witnessed.' Gentlemen appealed to differing forms of epistemic equipment in attempts to constitute zoology and psychology as disciplines. The relative success of such appeals was determined not only by the political valency of the claims themselves, but also by the conditions constituted by the types of equipment used to make them. The thesis then goes on to highlight ways in which the disciplined consideration of body and mind as entities determined by nature constituted conditions of possibility for the articulation of tool- and technique-centred subjectivities. The epistemic tools and representational claims appealed to as proof that the self is inherently organic (have) paradoxically participate(d) in the constitution of modes of being that extend the self into the realm of the technical. By the late nineteenth century, the capacities of cognition and replication are beginning to be attributed to the combination of technical and organic entities.
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Newsholme, David. "The life and works of William Davis (c. 1675/6-1745)." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/5162/.
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William Davis was a church musician who spent the majority of his life in the employ of Worcester Cathedral as chorister, player of the ‘little organ’, lay clerk and Master of the Choristers. It is therefore unsurprising that the substantial part of his compositional output is sacred. Nevertheless, there is also a large body of secular music, including an ode, a wedding song, several songs for soloist or duet and a handful of catches. Additionally there is a four movement suite for keyboard and two other keyboard solo pieces. The majority of Davis’ music appears to have been composed between 1695–1715. Writing about Davis, Ian Spink has asserted that ‘on this evidence [of the piece Let God arise] the composer would seem to be one of the more talented of Croft’s contemporaries’. More recently, he noted that ‘His [Davis’] anthems are good examples of what Croft’s provincial contemporaries were capable of’. Such comments inevitably invite closer consideration of Davis’ music in the light of his more illustrious London contemporaries. It is concluded that the best of Davis’ output is on a par with some of the music of Chapel Royal composers such as Croft and Clarke. Illustrative of this is that it has been possible to reattribute one full anthem (Help, Lord; for the Godly man ceaseth) to Davis, it previously having been ascribed to Croft. Davis was evidently the principal composer in Worcester at the beginning of the eighteenth century. A survey of his life and works therefore not only serves to enlarge our appreciation of Davis, but it also affords us better understanding of musical life in the city at that time. It is therefore hoped that this thesis will contribute to wider knowledge of the musical activity of the provinces in the late seventeenth and early eighteenth centuries.
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Cale, Michelle. "'Saved from a life of vice and crime' : reformatory and industrial schools for girls, c.1854-c.1901." Thesis, University of Oxford, 1993. https://ora.ox.ac.uk/objects/uuid:a551dd78-6ebc-4b0d-a2fe-693e74d5e19c.
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Reformatory and industrial schools were semi-penal Victorian institutions designed, firstly, to reclaim juveniles from a nascent criminal career and, secondly, to prevent neglected children from slipping into criminality. Most existing studies of these schools have been principally concerned with the campaigning philanthropists, such as Mary Carpenter, central government activity, and institutions for boys. This thesis utilises hitherto unused archival sources relating to individual institutions for girls in order to look at various aspects of reformatory life from the perspective of those by whom it was daily experienced. In addition to a consideration of the lives of the inmates, there are discussions of the motivations of the voluntary managers and the pay and conditions of the staff. A data base of industrial school cases from the Children's Society is analysed, in conjunction with other committal records, to ascertain which children were most likely to find themselves incarcerated. The importance of the respectability of a child's mother is particularly highlighted. The role of sexuality is discussed, in relation to attitudes towards girl delinquents, the selection of girls for committal, and the prevention of immorality within the schools. The internal disciplinary regime is considered in two chapters, the first concentrating on the forms of punishment and reward common throughout the reformatory system; and the second on the kinds of outburst and disturbance which contemporaries labelled hysterical, but which could be interpreted as calculated resistance to authority. Special attention is paid to the issue of corporal punishment. The socialising education in feminine, domestic skills which was provided in these institutions is the subject of a further chapter. Finally, the destinations of the 'reformed' girls on release is analysed, again using the Children's Society cases. The little which is known of their adult lives and various tokens of 'success' or 'failure' are delineated in an attempt to assess whether the schools accomplished their numerous aims.
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Gunn, S. J. "The life and career of Charles Brandon, Duke of Suffolk, c.1484-1545." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236165.
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Mina, Ibarra Leonardo Bruno. "Cellular mRNA decay factors involved in the hepatitis C virus life cycle." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7215.
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The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides acting as messengers for translation of viral proteins, they also act as templates for viral replication. Since these two functions are mutually exclusive, a key step in the replication of all (+) RNA viruses is the regulated exit of the genomic RNAs from the cellular translation machinery to the viral replication complexes. By using a model system that allows the replication of the plant (+) RNA Brome Mosaic Virus in yeast, it was shown by our group that the cellular decapping activators Dhh1, LSm1 and PatL1 play a key role in such transition. The LSm1 protein is a subunit of the LSm1-7 complexes. We have recently shown that these complexes interact directly with sequences in the BMV genome and that these interactions regulate the translation and replication of BMV. Interestingly, the LSm1 homolog in bacteria, Hfq, is required for the replication of the (+) RNA bacteriophage Qβ in E. coli.Since all (+)RNA viruses need to regulate the exit of the viral genome from the cellular translation machinery to replication and these proteins are conserved from yeast to humans, We hypothesized that the human homologues of Lsm1-7/Dhh1/Pat1 are required for the replication of human (+) RNA viruses. In this work we proved this hypothesis by showing that HCV translation and replication depend on these cellular proteins. Moreover, the requirement of these factors for efficient HCV RNA translation was linked exclusively to the 5´ and 3´ nontranslated regions (NTRs) of the viral genome. Furthermore, the LSm1-7 complex specifically interacts in vitro with essential cis-acting HCV RNA elements located in the NTRs.
El grupo de virus de RNA de cadena de polaridad positiva ((+)RNA) incluye numerosos patógenos de plantas, animales y humanos, tales como el virus de la Hepatitis C (VHC). Sus genomas virales imitan a los RNAm celulares, sin embargo, además de actuar como mensajeros para la traducción de proteínas virales, también actúan como moldes para la replicación viral. Debido a que estas dos funciones son mutuamente excluyentes, un paso clave en la replicación de todos los virus (+) RNA es la salida regulada del RNA genómico desde la maquinaria de traducción celular hacia las complejos de replicación virales. Utilizando un sistema modelo que permite la replicación del virus del mosaico del bromo (VMB), un virus (+) RNA de plantas, en levaduras, nuestro grupo ha demostrado que los activadores de decapping celulares Dhh1, LSm1 y Pat1 juegan un papel clave en este paso. La proteína LSm1 es una subunidad del complejo celular LSm1-7. Hemos demostrado recientemente que dichos complejos interactúan directamente con secuencias específicas en el genoma del VMB y que dichas interacciones regulan la traducción y replicación del VMB. De manera interesante, la proteína homologa de LSm1 en bacterias, Hfq, es necesaria para la replicación del bacteriófago (+) RNA Qβ en E. coli.
Debido a que todos los virus (+) RNA necesitan regular la salida del genoma viral desde la maquinaria traduccional de la célula hacia los complejos de replicación virales, y que las proteínas Dhh1, LSm1-7 y Pat1 están conservadas de levaduras a humanos, nuestra hipótesis es que lo homólogos humanos de Lsm1-7/Dhh1/Pat1 son requeridos para la replicación de virus (+)RNA de humanos. En este trabajo, hemos demostrado esta hipótesis mostrando que la traducción y la replicación del virus de la hepatitis C (VHC) dependen de estas proteínas celulares. Más aún, el requerimiento de estos factores para una eficiente traducción del genoma del VHC está vinculado de manera exclusiva a las regiones no traducidas (RNT) 5´ y 3´ del genome viral. Además, el complejo cellular LSm1-7 interactúa in vitro de manera específica con elementos esenciales del RNA del VHC que actúan en cis localizados en las RNTs.
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Carnell, Monique Marie. "The life and works of Maritime architect J. C. Dumaresq (1840-1906)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1993. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23851.pdf.
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Smith, Angela J. "The life and building activity of Bishop Richard Fox, c. 1448-1528." Thesis, University of London, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367013.
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Lauder, Anne Varick. "Battista Franco (c.1510-1561) : his life and work with catalogue raisonné." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614785.
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Graham, Fiona Caroline. "Ideology and practice in a Japanese company." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365668.
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Clark, James Gordon. "Intellectual life at the abbey of St Albans and the nature of monastic learning in England c.1350 - c.1440." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389585.
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Rizvanovic, Bianca, and Anne Kvibäck. "Att leva med kronisk hepatit C." Thesis, Växjö University, School of Health Sciences and Social Work, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-6147.
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Bakgrund: Hepatit C är en leverinflammation som orsakas av ett virus. HCV räknas som blodburen smitta. Den största riskgruppen för att få smittan är sprutnarkomaner, vårdpersonal och patienter som fick smittan i vårdsammanhang, innan blod som användes inom sjukvården testades på viruset.
Syftet: Att beskriva hur människor med kronisk hepatit C upplever att leva med sin sjukdom och hur bemötandet från sjukvården och omgivningen upplevs.
Metod: Litteraturöversikt med kvalitativ ansats. Sju vetenskapliga, kvalitativa artiklar användes och en manifest innehållsanalys genomfördes.
Resultat: Informanterna upplevde en förlorad tro på den egna kroppsförmågan och en sämre livssituation på grund av de fysiska sjukdomssymtomen. Att leva med hepatit C gjorde att framtiden kändes osäker och oförutsägbar. Familjen var ett viktigt stöd. De upplevde ofta negativa attityder och bemötande från omgivningen och sjukvården. Informanterna valde oftast att inte avslöja sin sjukdom på grund av rädsla för social utstötning. Sjukvårdens bemötande upplevdes ofta som fördomsfull och dömande av informanterna.
Slutsats: Sjukdomens fysiska symtom var tidvis så dominanta att hela personens liv påverkades. Omgivningens attityder kunde leda till utsatthet och utanförskap. Det fördomsfulla bemötandet medförde att många drabbade distanserade sig från sjukvården och fattade egna beslut kring sin vård. Bristen på kunskap om sjukdomen hos allmänheten och i sjukvården är viktig att uppmärksamma för att minska lidande.
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Greig, Hannah. "The beau monde and fashionable life in eighteenth-century London, c. 1688-1800." Thesis, Royal Holloway, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408112.
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Bertucci, Paola. "Sparks of life : medical electricity and natural philosophy in England c. 1746-1792." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365761.
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Robson, Samuel Charles. "Life or cell death : identifying c-Myc regulated genes in two distinct tissues." Thesis, University of Warwick, 2008. http://wrap.warwick.ac.uk/1064/.
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The c-myc oncogene is over-expressed or deregulated in many human cancers. c-myc encodes a transcription factor, the oncoprotein c-Myc (Myc), which acts as a master regulator of genes involved in such diverse cellular processes as replication and growth, loss of differentiation, invasion, and angiogenesis. Myc can also act as its own tumour suppressor by promoting cell death in the form of apoptosis. Thus, for putative cancer cells to arise, apoptosis must be blocked. Conditional MycERTAM transgenic mice allow regulated activation of Myc in distinct cell populations (skin suprabasal keratinocytes and pancreatic islet β-cells) and have highlighted contrasting behaviour between these two adult tissues in vivo: proliferation in the skin, and apoptosis in the pancreas. Given the crucial dependence on tissue location in vivo, we still do not know enough about the key divergence in Myc-regulated genes and proteins under conditions favouring opposing outcomes. To address this, we performed high-throughput transcriptome analysis using oligonucleotide microarrays. The in vivo transcriptional response to deregulated Myc was analysed for skin keratinocytes and laser-captured pancreatic islets following a time-course of MycERTAM activation. Due to the multi-factorial nature of the experimental design, novel statistical tools were developed allowing the use of linear models for inference of changes in gene-expression based on multiple experimental variables. Comparison of the transcriptional response between the two tissues identified potential signalling pathways which may promote apoptosis of β-cells or survival of skin keratinocytes: the DNA damage response pathway, and the Insulin-like growth factor 1 (Igf1) signalling pathway respectively. In addition, a marked change in expression was detected in members of the steroid hormone-regulated Kallikrein serine protease family in suprabasal keratinocytes but not for β-cells. These have been found to play an important role in regulating Igf1/Igf1-receptor ligation through proteolysis of the Igf1 binding proteins, are previously categorised markers for several human cancers, and may indicate a tissue-specific regulatory mechanism for determining ultimate Myc function in vivo.
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Boyce, Travis D. "I am Leaving and not Looking Back: The Life of Benner C. Turner." Ohio : Ohio University, 2009. http://www.ohiolink.edu/etd/view.cgi?ohiou1242396920.
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Thesis (Ph.D.)--Ohio University, June, 2009.Title from PDF t.p. Release of full electronic text on OhioLINK has been delayed until June 1, 2014. Includes bibliographical references (leaves 260-274)
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Pietsch, Kerstin. "Defining Quercetin-, Caffeic acid- and Rosmarinic acid- mediated life extension in C. elegans." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16460.
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Die mittlere Lebenserwartung des Menschen ist über die letzten 200 Jahre kontinuierlich gestiegen. Da Langlebigkeit ohne Gesundheit wenig Wert besitzt, ist es ein zentrales Anliegen, das Auftreten altersbedingter Krankheiten zu mindern. Besonders pflanzliche Phytochemikalien, im speziellen Polyphenole (PPs), sollen erheblich an der Gesundheitsförderung mitwirken. Die exakten Mechanismen jedoch, welche die Wirkvielfalt erklären könnten, sind nicht im Detail bekannt. Diese Fragen können nur durch in vivo Studien an Modelorganismen beantwortet werden, die sowohl die Lebensdauer, sowie physiologische und genetische Parameter einschließen. In dieser Studie wurden drei PPs mit lebensverlängernden Eigenschaften in C. elegans identifiziert: Quercetin (Q), Kaffeesäure (CA) und Rosmarinsäure (RA). Für alle drei PPs wurden hormetische Konzentration-Wirkungs-Kurven gefunden, dennoch war die Hormetin-typische Aktivierung einer Stressantwort (gemessen als Geneexpressions-Level von Hitzeschock-Proteinen) auf Q und RA beschränkt. Eine Umverteilung von Ressourcen nach dem Prinzip der „Disposable Soma Theorie“ konnte anhand von Abweichungen in der Größe, verändertem Lipid-Metabolismus und verzögerter Reproduktion (bei gleichbleibender Anzahl der Nachkommen), für alle drei PPs gezeigt werden. Während direkte CR-Effekte ausgeschlossen wurden, ist dies nicht möglich für durch CA und RA ausgelöste indirekte CR-Effekte, da beide die Lebensspanne von sir-2.1 Mutanten nicht verlängern konnten. Alle drei PPs verlängerten die Lebensspanne von mev-1 Mutanten, jedoch wurde eine erhöhte TAC in vivo und eine reduzierte oxidative Schädigung, nur durch Q- und CA- Gabe erreicht. Die genetischen Wirkwege der PPs wurden durch Lebensdauer- und Thermotoleranztests mit in alters-relevanten Genen mutierten Nematoden definiert. Die gesundheitsfördernden Eigenschaften von CA und RA konnten so osr-1, sek-1, sir-2.1 and unc-43, sowie daf-16 im Falle von CA, zugeschrieben werden. Die Mechanismen von Q wurden in größerem Umfang, durch die Integration von durchgeführten Lebensdauertests und Microarray-Studien einerseits und einer umfassenden Meta-Analyse von veröffentlichten, alters-relevanten Genexpressions-Profilen andererseits, analysiert. Q wirkt vermutlich durch ein komplexes Zusammenspiel von konservierten genetischen Signalwegen, im Speziellen dem Insulin-ähnlichen (ILS), TGF-beta, p38 MAPK, CAMKII und möglicherweise auch über eine von der Keimbahn und somatischen Gonade ausgehenden Signalwirkung. Zusammenfassend lässt sich sagen, dass sowohl in vivo antioxidative und prooxidative Eigenschaften, die Modulation auf Genebene, sowie eine Umverteilung von Ressourcen zu gewissen Teilen (abhängig vom PP) zur Lebensverlängerung beitragen.The mean life expectancy of humans has increased continuously over the last 200 years. Since longevity is of little value in the absence of health, it is a central request to prevent the increasing burden of age-related diseases. It is suggested that phytochemicals in plants, specifically the polyphenols (PPs), are important factors to support the overall well-being. However, the precise mechanisms that can explain, in full, the magnitude of impact remains elusive. This knowledge gap can only be plugged by in vivo model organism approaches that integrate lifespan assays with physiological, and genetic parameters following the ingestion of PPs. In this study, three PPs with life-extending properties in C. elegans were identified: Quercetin (Q), Caffeic acid (CA) and Rosmarinic acid (RA). The underlying mechanisms were systematically studied by a broad spectrum of functional and genetic investigations. For all three compounds, life extension was characterized by hormetic concentration-response curves, but stress-response induction, a hallmark of hormetin action, was restricted to Q and RA, at least when assessed at the level of gene expression of heat shock proteins. A reallocation of resources in a disposable soma-like pattern could be shown for all three PPs, because the exposure to Q, CA and RA resulted in variations in body size, altered lipid-metabolism and a tendency towards a delay in reproductive timing. However, the total number of offspring was unaltered. While direct CR effects arising from reduced food uptake could be rejected, an indirect CR effect cannot be excluded for CA and RA, as these PPs failed to provoke longevity in sir-2.1 mutants. Furthermore, the in vitro versus in vivo antioxidative properties were evaluated. While all three PPs could prolong mev-1 lifespan, only Q and CA were shown to increase the TAC in vivo and reduce oxidative damage in the nematodes. To define the genetic pathways of PP action, lifespan and thermotolerance assays were performed in mutant animals devoid of aging-relevant genetic players. These experiments revealed that the health gaining properties of CA and RA both rely on osr-1, sek-1, sir-2.1 and unc-43, plus daf-16 in the case of CA. The mechanisms of Q action are partly distinct and were analyzed in more detail by integrating own mutant lifespan assays and microarray studies with an extensive meta-analysis of published gene expression profiles obtained under aging-relevant conditions. Quercetin is proposed to act through a complex interplay of conserved genetic pathways, for example Insulin-like signaling (ILS), TGF-beta signaling, p38 MAPK, CaMKII, and possibly also due to germline and somatic gonad signaling. Taken together, hormesis, in vivo antioxidative/prooxidative properties, modulation of genetic players, as well as the re-allocation of resources all contribute (to some extent and dependent on the polyphenol) to life extension. Summary 1
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Boric, Dusan. "Seasons, life cycles and memory in the Danube Gorges, c. 10000-5500 BC." Thesis, University of Cambridge, 2002. https://www.repository.cam.ac.uk/handle/1810/272075.
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Bloy, Marjorie. "Rockingham and Yorkshire : the political, economic and social role of Charles Watson-Wentworth, the second Marquis of Rockingham." Thesis, University of Sheffield, 1986. http://etheses.whiterose.ac.uk/3012/.
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Charles Watson-Wentworth, second Marquis of Rockingham, is, perhaps, the most overlooked Prime Minister of the eighteenth century. The aim of this thesis is to re-examine the current assessments of the marquis, that he was immature, inept and unfit for high office, and to revise them as necessary. It also aims to indicate the areas where he may have been misjudged. The marquis primarily is placed in his local context of Yorkshire. His upbringing is studied to give same insight into his background and then his roles of landowner and local magnate are examined. His duties of Lord Lieutenant are dealt with by looking at four specific episodes in which he was involved. His political career is investigated at local level both as leader of the Rockingham party and particularly in his ability to influence Yorkshire politics between 1753 and 1782. The udder interests and concerns of Rockingham in Ireland and America are also studied. Rockingham showed great promise as a child although he suffered from a debilitating illness which recurred throughout his life and probably caused his sudden and early death. Far from being incompetent and immature, he was an active estate developer and improver and was a key figure in the social, economic and political life of the neighbourhood of Wentworth Woodhouse. He virtually controlled Yorkshire politics for twenty years and led the largest and best-organized opposition party in parliament during that time. His views on the problems of Ireland and America have been under-valued and his personal qualities both for attracting loyalty and friendship and for his active leadership of his party have not been given sufficient recognition. In spite of his faults Rockingham was far more capable and a far more complex person than has been realised.
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Saha, Jonathan. "Misconduct and the colonial state in everyday life : The Irrawaddy Delta, Burma c.1900." Thesis, SOAS, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535745.
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Hannan, Leonie K. J. "Women letter-writing and the life of the mind in England c. 1650-1750." Thesis, Royal Holloway, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538318.
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In England c. 1650-1750, before widespread formal schooling for girls or access to higher education for women, the life of the mind (broadly defined) is an important, yet unexplored, field of female experience. It is studied here via the mechanism of letterwriting. Corresponding provided motivated women with not only a forum but also the impetus to engage with intellectual life. By picking up the pen idle musings could be transformed into considered sentences; passively absorbed meanings into actively discussed ideas. From a source base of approximately 4,000 private letters, around 500 were chosen for closer analysis. Intellectual and everyday lives have traditionally been studied separately. Here it is shown that, for women, these two worlds were not only interconnected but that they impacted upon one another in significant ways. After the historiographical introduction (Chapter One), the first two research chapters (Chapters Two and Three) examine letterwriting as an interactive social process, showing that prescriptive literature was not an accurate guide to actual epistolary norms. Chapters Four and Five explore the material and intellectual qualities of a seventeenth-century letter-writer's correspondence networks, taking Mary Evelyn as a case-study. Chapter Six then analyses the ways in which the domestic spaces, inhabited by women, affected their abilities to pursue contemplative activities. Chapter Seven draws together the spatial and temporal concerns expressed by a wider cross-section of women in their letters about the `life of the mind' and the final chapter assesses what intellectual life meant for women at this time. Overall, the case is made for a broader conceptualisation of female intellectualism. The societal codes unfavourable to educating women did not, in fact, eradicate motivations to learn, think and discuss. This research does not propose a model of linear progression, but makes the important point that female aspiration grew upon unstable foundations, born out of a complex patchwork of opportunity and obstacle. As a result, it produced uncertain progress. But, where some achieved, others might follow
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Ó, Muraíle Nollaig. "The celebrated antiquary Dubhaltach Mac Fhirbhisigh (c. 1600-1671) : his lineage, life and learning /." Maynooth (Ireland) : An Sagart, 1996. http://catalogue.bnf.fr/ark:/12148/cb35846390b.
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Texte remanié de: Diss. Ph. D.--Dublin--National university of Ireland, 1991. Titre de soutenance : The Background, life and writings of Dubhaltach Mac Fhirbhisigh (d. 1671).Bibliogr. p. 381-408. Index.
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Cannon, Maria. "Families in crisis : parenting and the life cycle in English society, c. 1450-1620." Thesis, Northumbria University, 2015. http://nrl.northumbria.ac.uk/30331/.
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This thesis offers a new perspective on the nature and experience of parent-child relationships c.1450-1620. Focusing on correspondence and family papers from selected aristocracy and gentry families, it argues that authority in parent-child relationships was renegotiated throughout the life cycle, particularly at points of tension or crisis such as marriage or death. These ‘crisis points’ are episodes which show us the negotiations that took place around domestic authority and give a personal insight into the emotional responses of parents and children and the nature of authority within early modern society. This thesis addresses a gap in knowledge about the changing reciprocal nature of this relationship over the life course. It understands ‘parent’ and ‘child’ as relational statuses experienced differently at different points throughout the life cycle. These new definitions argue that ‘parent’ and ‘child’ were not statuses that were limited to a single life stage but impacted on an individual throughout life. It reveals that individuals were motivated by societal expectation of family roles and also exhibited a range of emotional responses in reaction to perceived threats to the smooth running of family life according to the rules and structures of age, gender and status. The expectations associated with being a parent or a child continued to shape the actions and behaviour of individuals well into adulthood, as loyalty and obedience between parents and children was challenged and renegotiated. The thesis also considers how different roles within the family could overlap, leading to conflict as family members sought to manage their obligations and responsibilities as parents, children, siblings or step-relations. The personal source material is put into context with legal records and conduct literature considering the conflict between ideals of family life and its lived experience.
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Alvarez, Italo, Juan C. Urbina, and Romina A. Tejada. "Chronic hepatitis C and health-related quality of life in patients with cognitive impairment." S. Karger AG, 2018. http://hdl.handle.net/10757/624654.
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Imanikia, Soudabeh. "C. Elegans & anorectic herbal extracts : defining molecular-genetic responses & life-cycle consequences." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/c-elegans--anorectic-herbal-extracts-defining-moleculargenetic-responses--lifecycle-consequences(94b26731-f348-4c95-8c33-449b617e16b5).html.
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An imbalance between energy uptake and energy expenditure can lead to obesity and increase the risk of coronary heart disease, high blood pressure, stroke, type II diabetes and some cancers. Given that key elements of energy pathway are evolutionary conserved, invertebrate research is an attractive alternative that overcomes the many legislative, financial and experimental hurdles typical of research with higher metazoan animals. The nematode Caenorhabditis elegans is a premier invertebrate model and has been utilized to study a wide range of topics of biomedical research including obesity, aging, toxicology, pharmaceutical and drug delivery approaches. Previous studies have suggested that raw extracts from a South African succulent (Hoodia gordonii) and P57 (the main active compound of the extracts) may exert an appetite suppressant effect. To investigate this notion in more detail, this present study aimed to pinpoint phenotypic, genetic and genomic-level responses of C. elegans treated with H. gordonii extract. Supplementing the bacterial food source with H. gordonii extract resulted in a significant reduction in growth parameters and the pharyngeal pumping rate as well as the fecundity. Likewise, it diminished the overall level of Nile Red positive compartments, which is indicative of a change in lipid metabolism. Comprehensive transcriptomics revealed that several genes involved in aging, lipid transport and reproduction were modulated following the exposure to the crude extract and pure P57. Based on these results, selected deletion mutants were studied in more detail, including fat-5 (a member of the Δ9 desaturases) and cyp-35A2 (a member of the cytochrome P450 family). The creation of a fat-5(tm420);cyp-35A2(gk317) mutant uncovered that the deletion of both genes resulted in a strain which is marked by a reduced fat content and an extended lifespan. Taken together, the results suggest the presence of a putative correlation between longevity and dietary restriction and given that both genes have human homologs, this finding may offer a new lead to investigate in higher organisms.
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Flame, Michael John. "'All the common rules of social life' : the reconstruction of social and political identities by the Dorset Gentry, c.1790-c.1834." Thesis, University of Warwick, 1997. http://wrap.warwick.ac.uk/3982/.
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This case-history explores the governing purposes of the Dorset gentry from the early 1790's until the mid 1830's. It is not a conventional political and administrative history. It seeks rather to reveal the gentry's governing purposes through the processes and contexts of their construction of social and political identities. It takes as its starting point the idea of the materiality of language itself The idea that language does not reflect or refer to a pre-existing anterior reality but creates meaning by distinguishing explicitly or implicitly what something is from what it is not. This case-history explores the gentry's construction of the terms of an overarching discourse I have called the 'common rules of social life'. In particular the evolving narrative terms of patriarchal oeconomy, political economy and paternalism. It does so to answer the question: 'By what means and for what purposes did this form of discourse and its narrative traditions become established by the gentry to prevail at this time in the past? ' The answers are found in the ways and the contexts in which the gentry used this discourse. First, how did the gentry exercise their power so that this discourse might come into being. Here the structures and institutions of the Commission of the Peace are significant. In particular the ways in which power was monopolised and used by a small fraction of active magistrates. This fraction was active in the committees of the Commission of the Peace and at quarter and petty sessions. Their power came to be deployed to reform county government and poor relief to impose 'natural' moral market relations on Dorset society. Second, how was the discourse and its constituent elements exercised by the gentry to constitute identities, and how did they determine how people thought and acted? Here the case-history reveals the gentry's construction of identities for Dorset, the parish and the poor. In particular the construction of an identity of Dorset as an arena of natural economic laws and moral endeavour. These identities were taught to rich and poor alike as part of the gentry's purpose to remoralise Dorset society.
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Machado, Danusa de Almeida [UNESP]. "Qualidade de vida e morbidade psicológica de pacientes portadores de hepatite C em tratamento com interferon peguilado e ribavirina." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/98430.
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machado_da_me_botfm.pdf: 1394729 bytes, checksum: cf122227c1c036a13854129f11cd25e1 (MD5)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O presente estudo teve por objetivo descrever características sóciodemográficas, psicossociais, clínicas, índices de qualidade de vida, ocorrência de transtorno mental comum, de sintomas depressivos de pacientes portadores de Hepatite C crônica, em tratamento no Ambulatório de Hepatites Virais da Disciplina de Gastroenterologia Clínica do HC da FMB-UNESP, em três momentos de seu tratamento com Interferon Peguilado e Ribavirina: antes do início, nas 12ª e 24ª semanas de tratamento. Foram também estudadas as associações das variáveis sócio-demográficas e clínicas, de transtorno mental comum (TMC), sintomas depressivos, da forma de tratamento com índices de qualidade de vida (QV) nos três momentos estudados e com os resultados de exames indicativos da resposta virológica ao tratamento (detecção do RNA do vírus da Hepatite C pelo método de PCR). Método: Realizou-se estudo transversal e de seguimento. Uma amostra de conveniência foi estabelecida, tendo-se estudado 82 pacientes no estudo transversal e feito o seguimento de 46 no terceiro e sexto mês após o início do tratamento. Utilizou-se formulário estruturado para investigar aspectos sócio-demográficos e clínicos. Sintomas depressivos foram avaliados pelo Beck Depression Inventory (BDI). Utilizou-se o Self Reporting Questionnaire (SRQ) para avaliar Transtorno Mental Comum e o uso nocivo de álcool foi avaliado por meio do Alcohol Use Disorders Identification Test (AUDIT). A qualidade de vida foi estudada por meio do The Medical Outcomes Study 36 item Short-Form Health Survey (SF-36). O estudo das associações entre variáveis categoriais foi feito pelo teste do Qui–quadrado (ou Fisher, se adequado). Os Testes de Mann–Whitney e de Kruskal Wallis foram utilizados para comparar as distribuições dos vários domínios do SF-36. Para comparação entre os dados nos momentos subseqüentes foram...
This study aimed at describing socio-demographic, psychosocial and clinical characteristics as well as quality of life indexes, occurrence of common mental disorder and depressive symptoms of patients with chronic hepatitis C undergoing treatment at the Viral Hepatitis Outpatient Unit of the Botucatu Medical School – UNESP, at three different moments of their treatment with Peguilated Interferon and Ribavirin: immediately before treatment, 12 and 24 weeks after its introduction. The association of socio-demographic and clinical variables as well as those for common mental disorder (CMD), depression symptoms and form of treatment with quality-of-life (QL) indexes was evaluated at the three studied moments. The association of such variables with test results indicating virological response to treatment (detection of the hepatitis C virus RNA by the PCR method) was also investigated. Method: A convenience sample was established, and 82 patients were studied in a cross-sectional and follow-up investigation. Forty-six patients were followed 3 and 6 months after the beginning of treatment. A structured questionnaire was used to investigate socio-demographic and clinical aspects. Depression symptoms were evaluated by the Beck Depression Inventory (BDI). The Self Reporting Questionnaire (SRQ) was utilized to evaluate common mental disorder, and harmful use of alcohol was evaluated by the Alcohol Use Disorders Identification Test (AUDIT). Quality of life was assessed by the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). The study of the associations between categorial variables was performed by the chi-square test (or Fisher, if adequate). The Mann-Whitney and Kruskal Wallis tests were used to compare the distribution of various domains of SF-36. McNemar’s Exact Test was used for category variables to compare the data at the subsequent moments, and Friedman’s Test was... (Complete abstract click electronic access below)
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Pérez, Vilaró Gemma 1985. "Cellular processing bodies and the hepatitis C virus life cycle : characterization of their dynamic interplay." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/97092.
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Els cossos de processament (cossos-P) són grànuls discrets i dinàmics que contenen mRNAs represos en la traducció així com proteïnes involucrades en la degradació dels mRNAs i de la maquinària dels miRNAs. Alguns components dels cossos-P, com els repressors de la traducció PatL1, LSm1 i DDX6, promouen la traducció i la replicació del virus de la hepatitis C (VHC) i d’altres virus RNA de polaritat positiva [RNA(+)]. A més a més, un genome wide screening en llevat va determinar que l’exonucleasa Xrn1, que també es localitza als cossos-P, pot afectar la taxa de recombinació d’un virus RNA(+) de plantes Així doncs, els components dels cossos-P estan estretament relacionats amb els cicles vitals dels virus RNA(+).
En l’estudi que aquí es presenta hem explorat la relació del VHC amb els cossos-P, demostrant que la infecció pel VHC promou canvis en la composició dels cossos-P a través de l’alteració de la localització d’aquells components que són necessaris per a la replicació viral. A més a més, hem demostrat que els components dels cossos-P però no els grànuls per se són necessaris per a la replicació del VHC. Addicionalment, hem posat a punt un sistema de detecció de recombinació en cultiu cel•lular basat en replicons del VHC que permet analitzar successos de recombinació i caracteritzar la possible participació dels components dels cossos-P en aquest mecanisme d’evolució. Amb aquest sistema s’han establert les primeres estimacions en la freqüència de recombinació del VHC indicant que la recombinació en aquest virus no és gaire comú. A més a més, la reducció del nivell d’expressió de Xrn1 no va alterar la taxa de recombinació del VHC indicant que la utilització de l’exonucleasa no és una característica general en la recombinació dels virus RNA(+). En conjunt, aquests resultats incrementen el nostre coneixement sobre els aspectes bàsics de la biologia del VHC així com de l’estreta relació que aquest virus estableix amb l’hoste.
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Byrne, Jonathan [Verfasser]. "Identification of novel regulators of late-life longevity in the worm C. elegans / Jonathan Byrne." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1175402745/34.
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O'Brien, James Leslie Graham. "Ruralism and Englishness : meaning in paintings of English rural life and labour, c. 1870-1905." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324225.
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This thesis examines visual representations of English country life and labour in the period 1870 to 1905 in relation to contemporary beliets in the centrality of the rural world to conceptions of national identity and'Englishness'. Centering upon an analysis of oil and watercolour paintings, but also interrogating prints, posters and photographs, the thesis examines the ways in which the production and consumption of images of rural lite in the period addressed and articulated widespread elite cultural concerns over a complex range of social issues, including purported racial degeneration, growing class conflict, and the checking of British imperial ambitions. Divided thematically into five distinct yet interlinked chapters, the thesis investigates firstly the stylistic evolutions in the painting of rural life across the period, and the connections made between particular visual languages and notions of a'national' school of art. The second chapter focuses upon an assessment of pictorial representations of the farmworker, looking in particular at the ways in which visual descriptions of rural labourer's bodies explored ideas of racial identity and national character. Chapters Three and Four look in turn at the representation of the country village and of field sports, the chapters both individually and cumulatively charting the relationship between visual culture and the generation of ideas around community,d eferencea nd social cohesion. The final section addressesth e portrayal of agricultural work, looking specifically at the themes of ploughing and mechanisationa, nd the cultural negotiationo f signso f modernity in the countryside. Treating visual images not as historically-transcendant objects, but as significant elements within a particular and specific material culture, the thesis compares visual images to other contemporary accounts of rural life, including those offered in novels, poetry and agricultural journalism. It views paintings of rural life and labour as critical spaces in which contemporary elite ideologies were actively articulated and contested, describing paintings of the rural world not as sites of settled meaning, but rather as formative elements of a dynamic process that continually re-worked and reevaluated evolving conceptions of rurality and'Englishness'.
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Henderson, J. Mary. "Piety and heresy in medieval Orvieto : the religious life of the laity, c. 1150-1350." Thesis, University of Edinburgh, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259175.
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Brabbins, Lucinda J. "Accepting the 'Big C' : exploring the acceptance-quality of life relationship in a cancer population." Thesis, University of Lincoln, 2016. http://eprints.lincoln.ac.uk/29724/.
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There is a high prevalence of distress amongst cancer patients, with up to 40% reporting clinically-significant levels of distress, such as depression, anxiety, and death anxiety. Acceptance and Commitment Therapy (ACT) has a growing evidence base in health populations, such as in diabetes and chronic pain, counteracting the avoidant behaviours which are negatively implicated in outcomes. ACT claims that experiential acceptance is key to shifting the avoidant responses people exhibit towards their inner experiences and psychological pain. Thus far, there is limited research exploring ACT processes within a cancer population. Traditional existentially-informed theory has claimed that accepting death anxiety would be psychologically paralysing and that mortality must be defended against, yet evidence for acceptance suggests the opposite. This study therefore aimed to explore the relationship between acceptance and outcomes of quality of life and distress in a cancer population, in order to explore the implications for an accepting response style, and also whether avoidant or approach response styles were implicated in better or worse psychological outcomes. Using a longitudinal design, six standardised questionnaires, well-utilised in cancer populations, were issued to 72 adults with experience of cancer, measuring clinical variables, cancer appraisals, response styles, and both quality of life and distress outcomes. The addition of a follow-up questionnaire, completed by 31 participants after three months, allowed for predictive and cross-lag analyses to be carried out. Results showed acceptance to be an independent explanatory and predictive response style variable for both quality of life and distress outcomes, in the direction of psychological health. ‘Avoidant’ response styles were negatively implicated in outcomes, and many ‘approach’ response styles other than acceptance did not reach correlational significance with outcome variables. Acceptance and avoidant response styles remained stable over time, whilst outcomes continued to change, and acceptance was thought to be driving future outcomes in a one-way direction. 5 The findings support the notion that experiential acceptance is implicated in beneficial psychological outcomes for cancer populations, rather than being detrimental to functioning, as suggested by existential theorists. Acceptance demonstrated significantly more influence over outcomes than either disease characteristics or threatening illness appraisals, and may influence future functioning. Furthermore, avoidant responses to cancer-related experiences were negatively implicated in psychological distress and also quality of life, which continued to deteriorate over time despite avoidant response styles remaining stable. Acceptance may be a helpful and influential response style, given that it predicts and potentially influences future functioning, and may provide a reasonable treatment target for psychological intervention with cancer patients, over and above the direct targeting of cancer appraisals. Objective. 40% of cancer patients may experience clinically-significant levels of distress, yet evidence for appropriate psycho-oncological interventions remains lacking. This study aimed to explore acceptance, as defined by acceptance and commitment therapy (ACT), in cancer patients. Primary aims investigated whether acceptance was related to and predictive of better quality of life and distress outcomes, and whether acceptance interacted with cancer appraisals to influence outcomes. Design. Longitudinal, quantitative design with a follow-up after three months. Participants completed a battery of questionnaires at times one and two. Measures. 72 participants completed standardised questionnaire batteries comprising: Brief Illness Perception Questionnaire; Brief COPE; Acceptance and Action Questionnaire II; Hospital Anxiety and Depression Scale; Functional Assessment of Cancer Therapy – General (FACT-G); and Death Anxiety Scale (DAS). 31 participants repeated the battery after three months. Results. Acceptance was an independent explanatory and predictive variable for quality of life and distress scores, in the direction of psychological health, and predicted functioning over time. Acceptance had greater explanatory power for outcomes than either cancer appraisals or avoidant response styles, including denial and self-distraction. Avoidant response styles showed significant associations with outcomes, but in the directions of greater distress and poorer quality of life. Conclusions. The findings support the role of an accepting response style in improved psychological outcomes. Avoidant responses were consistently related to poorer outcomes in a population with distress and death anxiety. Acceptance predicts functioning, and is supported as a helpful response style for cancer patients.
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Givens, Kathy E. "What Gives Your Life Meaning (WGYLM(c))| Increasing High School Students' Awareness of Palliative Care." Thesis, California State University, Long Beach, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10785881.
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As the nation ages, many adolescents will become caregivers for a burgeoning population of elders. These adolescents will have had little training and information on how to address a loved one’s psychosocial needs. This thesis evaluated if a week-long “What Gives Your Life Meaning” (WGYLM©) program increased awareness of and improved attitudes about palliative care (PC) among high school students.
Fourteen (14) high school students participated in this week-long study by viewing clips from the movie Being Mortal, participating in a discussion with a palliative care professional, listening to an interview with an adolescent caregiver, and answering questions relative to end of life. The students’ accurate definition of palliative care as care focused on quality of life increased from 57% to 78%. Results suggested that a school based WGYLM© program would benefit adolescents’ knowledge and attitudes about PC.
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FOWLER, CHRISTOPHER L. "ILLNESS REPRESENTATIONS, COPING, AND QUALITY OF LIFE IN PATIENTS WITH HEPATITIS C UNDERGOING ANTIVIRAL THERAPY." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1178120919.
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Raj, Meera. "Biological roles of cellular glyceraldehyde-3-phosphate dehydrogenase in the hepatitis C virus life cycle." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54275.
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The hijacking and manipulation of host cell biosynthetic pathways by human viruses are shared molecular events that are essential for the viral life cycle. Because of increasing evidence of the importance of human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in host secretory pathway functions, I hypothesized that this multifunctional enzyme could contribute to life cycles of two Flaviviridae members, hepatitis C virus (HCV) and dengue virus (DENV).
The first aim of this project was to investigate whether GAPDH is a host factor that regulates the life cycle steps of HCV in human hepatoma Huh-7.5.1 cells. I used short interfering RNA (siRNA)-mediated silencing of GAPDH both pre- and post-HCV infection in Huh-7.5.1 cells to demonstrate that reducing GAPDH protein abundance inhibits primary HCV infection and production and/or release of infectious HCV virus particles. Exogenous expression of V5-tagged human GAPDH, pre- and post-infection, increases the viral infectivity of HCV-infected Huh-7.5.1 cell supernatants, suggesting a predominant role of GAPDH during the post-replication steps of the HCV life cycle. Finally, siRNA-mediated GAPDH suppression in human Huh-7.5.1 cells also significantly inhibited primary DENV-2 infection.
In the second aim, I further investigated the diverse functions of GAPDH in human hepatoma cells by performing differential expression profiling of total cellular proteins by quantitative proteomics in two GAPDH knockdown Huh-7-derived cell lines (67D2 and 67b3) and the parental Huh-7 cell line. First, I successfully established GAPDH knockdown Huh-7-derived cell lines using short hairpin RNA (shRNA) lentivirus particles. Second, I demonstrated that the stable shRNA-mediated GAPDH silencing in Huh-7 cells inhibits primary HCV infection and the production of infectious HCV virus particles. Using a quantitative proteomics strategy based on triplex dimethyl labeling and nano-liquid chromatography-tandem mass spectrometry, I determined the cellular proteins deregulated in 67D2 and 67B3 cells. Bio-informatic analysis of the differentially expressed proteins revealed a robust compensatory effect in molecular functions associated with enzymatic activities and “acting binding” in response to the silencing of GAPDH in 67D2 and 67D3 cells.Science, Faculty of
Microbiology and Immunology, Department of
Graduate
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Strauchen, Elizabeth Bradley. "Giovanni Puzzi : his life and work : a view of horn playing and musical life in England from 1817 into the Victorian era (c.1855)." Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:e42fa98b-daf6-454b-9f54-2a79588d5120.
Full textAbstract:
The focus of this dissertation is a comprehensive study of the life and work of Giovanni Puzzi, nineteenth-century Britain's most celebrated virtuoso of the horn. In his hands, the horn -- hitherto largely known to England's aristocracy as an obstreperous member of the orchestra or popular form of pleasure garden entertainment became a sought-after attraction at London's most fashionable and exclusive concerts. An examination of Puzzi's activities as an orchestral player and as a soloist in a wide variety of public and private concerts chronicles his rise to celebrity and establishes his position in London's concert life. Equally impressive was Puzzi's sustained prosperity in a notoriously difficult business. Key to this triumph was his multifaceted exploitation of the Italian opera. Through his activities as an agent, impresario and arranger he allied himself as a fixer and performer with his era's most lucrative musical commodity: the singers of the Italian opera. In the large body of music that he arranged and composed to capitalise on audience fascination with virtuosity and opera, Puzzi has provided the only substantial record of horn playing in Britain during the nineteenth century. The majority of fhe manuscripts considered in this dissertation are drawn from a private collection and have not been previously studied or published. This material, in conjunction with Puzzi's surviving instruments and critical accounts of his playing, has been utilised to reconstruct and assess the main attributes of his virtuosity. This dissertation shows that Puzzi was responsible for establishing the preference for French style instruments and performance technique in England and that he was the first exponent of the British school of horn playing that reached its culmination in Dennis Brain. While virtuoso string players, pianists and singers have attracted much attention from scholars and biographers, this dissertation is the first full length historical study of a nineteenth-century horn virtuoso to be written.
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Tolley, Rebecca. "Review of Life Stories of Women Artists 1550-1800." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/5654.
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Couch, Georgina Elizabeth. "The cultural geography of the suburban garden : landscape and life history in Nottingham c.1920-1970." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416399.
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