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Liu, F., and R. A. Roth. "Identification of serines-967/968 in the juxtamembrane region of the insulin receptor as insulin-stimulated phosphorylation sites." Biochemical Journal 298, no. 2 (March 1, 1994): 471–77. http://dx.doi.org/10.1042/bj2980471.
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A line of Chinese hamster ovary cells overexpressing protein kinase C alpha was transfected with cDNAs encoding either the wild-type human insulin receptor or one of two mutant insulin receptors with either Ser-967 and -968 or -974 and -976 in the juxtamembrane region changed to alanine. Both mutant receptors exhibited normal insulin-activated tyrosine kinase activity as assessed by either autophosphorylation or insulin-stimulated increases in anti-phosphotyrosine-precipitable phosphatidylinositol 3-kinase. The wild-type and mutant insulin receptors were also examined for serine and threonine phosphorylation in response to insulin and activation of protein kinase C. To visualize Ser/Thr-phosphorylation sites of the receptor better in response to insulin, the receptor from in vivo-labelled insulin-treated cells was first treated with a tyrosine-specific phosphatase to remove all tyrosine phosphorylation. Phosphopeptides from the three receptors were analysed by high-percentage polyacrylamide/urea gel electrophoresis and two-dimensional t.l.c. The mutant receptor lacking Ser-967 and -968 but not the mutant lacking Ser-974 and -976 was found to be missing phosphorylated peptides in response to insulin and, to a lesser extent, after activation of protein kinase C. However, the insulin-stimulated increase in anti-phosphotyrosine-precipitable phosphatidylinositol 3-kinase was inhibited to the same extent by activation of protein kinase C in cells expressing the two mutant receptors as in cells expressing the wild-type receptor. These results indicate that these four serine residues in the juxtamembrane region are not major regulatory sites of the intrinsic tyrosine kinase activity of the insulin receptor by protein kinase C, although Ser-967 and/or -968 appear to be phosphorylated in response to insulin.
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Shamsuzzoha, M., and B. W. Lucas. "New crystal data (neutron) for phase II rubidium nitrate at 513 K." Journal of Applied Crystallography 21, no. 1 (February 1, 1988): 74–75. http://dx.doi.org/10.1107/s0021889887010070.
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Indexed neutron powder diffraction data of phase II RbNO3 indicate a body-centred cubic unit cell [a = 8.84(3) Å at T = 513 K, V = 690.1(52) Å3, Z = 8, Dx = 2.84(2) Mg m−3, λ = 1.083 Å, possible space groups include I23, I213, Im3, I432, I{\bar 4}3m or Im3m] in preference to the previously reported tetragonal cell {a = 6.19, c = 8.74 Å, Z = 4 [Brown & McLaren (1962). Acta Cryst. 15, 974–976]}, or trigonal cell {a ≃ 5.48, c ≃ 10.71 Å, Z = 3 [Ahtee & Hewat (1980). Phys. Status Solidi A, 58, 525–531]}.
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SO, Hideya, Atsuya ANDO, Tomohiro SEKI, Munenari KAWASHIMA, and Takatoshi SUGIYAMA. "Multiband Sector Antenna with the Same Beamwidth Employing Multiple Woodpile Metamaterial Reflectors." IEICE Transactions on Electronics E97.C, no. 10 (2014): 976–85. http://dx.doi.org/10.1587/transele.e97.c.976.
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Yan, Zhong-Hua, and Shuai Zhou. "Study of the characteristics of 976 nm Bragg grating external cavity semiconductor lasers." Modern Physics Letters B 32, no. 19 (July 9, 2018): 1850214. http://dx.doi.org/10.1142/s0217984918502147.
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976 nm fiber Bragg grating (FBG) external cavity laser is the core component in erbium-doped fiber amplifiers (EDFA). In this paper, the theory model of FBG is modeled by transfer matrix method (TMM). The effects of Bragg grating length and modulation depth on the reflectivity, grating spectrum width and wavelength have been investigated. Then 976 nm laser modules with different grating reflectivity, i.e. 4%, 6%, 8% and 10% have been fabricated. By improving the reflectivity of FBG, the side-mode suppression ratio (SMSR) has been optimized to above 40 dB, and the threshold current decreases. The temperature cycling test indicates that the peak wavelength has a change rate [Formula: see text]0.0095 nm/[Formula: see text]C.
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Dinić, Ivana, Marina Vuković, Maria Eugenia Rabanal, Milica Milošević, Marta Bukumira, Nina Tomić, Miloš Tomić, Lidija Mančić, and Nenad Ignjatović. "Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF3 and YF3 Mesocrystals." Journal of Functional Biomaterials 15, no. 1 (December 22, 2023): 6. http://dx.doi.org/10.3390/jfb15010006.
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Y0.8−xGdxF3:Yb/Er mesocrystals with a biocompatible surface and diverse morphological characteristics were successfully synthesized using chitosan-assisted solvothermal processing. Their structural properties, studied using X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning and transmission electron microscopy and energy dispersive X-ray analysis, were further correlated with the up-conversion emission (λexc = 976 nm) recorded in function of temperature. Based on the change in the visible green emissions originating from the thermally coupled 2H11/2 and 4S3/2 levels of Er3+, the corresponding LIR was acquired in the physiologically relevant range of temperatures (25–50 °C). The detected absolute sensitivity of about 0.0042 °C−1, along with the low cytotoxicity toward both normal human lung fibroblasts (MRC-5) and cancerous lung epithelial (A549) cells, indicate a potential for use in temperature sensing in biomedicine. Additionally, their enhanced internalization in cells, without suppression of cell viability, enabled in vitro labeling of cancer and healthy cells upon 976 nm laser irradiation.
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Zhang, Yunqi, Yumei Zhu, and Zhihong Li. "Preparation and Characterization of Carbide Particle-Toughened Si–B System of High Thermostability Polycrystalline Diamond by HPHT Sintering." Materials 16, no. 11 (May 24, 2023): 3933. http://dx.doi.org/10.3390/ma16113933.
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In this research, we report the synthesis of Si–TmC–B/PCD composites using Si, B, and transition metal carbide particles (TmC) as binders at high pressure and high temperature (HPHT method, 5.5 GPa and 1450 °C). The microstructure, elemental distribution, phase composition, thermal stability, and mechanical properties of PCD composites were systematically investigated. The Si–B/PCD sample is thermally stable in air at 919 °C. The initial oxidation temperature of the PCD sample with ZrC particles is as high as 976 °C, and it also has a maximum flexural strength of 762.2 MPa, and the highest fracture toughness of 8.0 MPa·m1/2.
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Nady, Ahmed, Florent Cassouret, Pavel Loiko, Simone Normani, Alain Braud, Weidong Chen, Valentin Petrov, et al. "Polarization-anisotropy of mid-infrared emission properties of Er3+ ions in YAlO3 crystal – INVITED." EPJ Web of Conferences 287 (2023): 05010. http://dx.doi.org/10.1051/epjconf/202328705010.
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We report on a polarization-resolved study of mid-infrared emission properties of Er3+ ions in the orthorhombic YAlO3 crystal. For the 4I11/2 → 4I13/2 transition, σSE reaches 0.20×10-20 cm2 at 2919 nm (for light polarization E || c). Pump-induced polarization switching between the E || b and E || c eigen-states is observed in an 10 at.% Er:YAlO3 laser. Pumped by an Yb-fiber laser at 976 nm, this laser delivers 0.77 W at 2919 nm with a slope efficiency of 31.4% being close to the Stokes limit and a laser threshold of 33 mW.
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Park, Junghyun, and Marc Rodger. "Retrospective Cohort of Unprovoked Venous Thromboembolism Patients: What Proportion Have Potent Thrombophilias Necessitating Indefinite Anticoagulants?" Blood 126, no. 23 (December 3, 2015): 2318. http://dx.doi.org/10.1182/blood.v126.23.2318.2318.
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Introduction Thrombophilia testing in unprovoked venous thromboembolism patients (VTE) is controversial. Common thrombophilias such as Factor V Leiden or prothrombin gene variant appear to not importantly increase the risk of VTE recurrence, and thus are not considered in anticoagulation management decisions. However, patients with potent thrombophilias such as antiphospholipid antibodies (APLA), antithrombin deficiency, protein C and S deficiency, and homozygous genetic thrombophilias or combined defects are at higher risk of recurrence and it is recommended that they receive long-term anticoagulation. If the proportion of patients with "potent" thrombophilia is high then thrombophilia testing should be conducted. We sought to determine the proportion of unprovoked VTE patients with "potent" thrombophilia. Methods All patients with managed in our oral anticoagulation management system in the period from 1998 to 2015 were potentially eligible for the study. Inclusion criteria were: 1) symptomatic, objectively confirmed VTE unprovoked proximal deep vein thrombosis or pulmonary embolism. Exclusion criteria were: 1) cancer or myeloproliferative disease at the time of VTE diagnosis; 2) no cast, surgery, trauma or immobilization (>3 days in bed 90% of waking hours) in the 90 days prior to diagnosis. We selected unprovoked VTE patients diagnosed between 2002 and 2010, as thrombophilia testing was relatively universal and available in our electronic system in that time frame (N=1344). We then selected a convenience sample of N=1165. The primary outcome measure was the proportion of patients with "potent" thrombophilia (potent= homozygous Factor V Leiden, homozygous Prothrombin gene variant, APLA, protein C, protein S or anti-thrombin deficiency or combined deficiencies). Results In 1165 patients with unprovoked VTE, complete screening was done in 470 patients (40.34%) and 976 (83.78%) had at least one thrombophilia test. Complete thrombophilia testing was defined as a screen including testing for factor V Leiden, prothrombin gene defect, APLA, anti-thrombin deficiency, protein C, and protein S. Potent thrombophilias were demonstrated in 103/1165 patients (8.84%; 95% CI, 7.34 to 10.61) (Table 2) in the total study population, and 103/976 (10.55%; 95% CI, 9.62-14.47) in patients with at least one thrombophilia test. Conclusion The proportion of unprovoked VTE patients with "potent" thrombophilia is high. Given a high proportion of "potent' thrombophilia patients who likely benefit from indefinite anticoagulation, complete thrombophilia testing appears warranted in patients with unprovoked VTE in whom anticoagulants maybe discontinued. Thrombophilia testing is warranted for a selected group of patients to detect high-risk thrombophilias that could impact anticoagulation management. Table 1. Thrombophilia screening Complete screening 470 (40.3%) No screening 189 (16.2%) At least one thrombophilia test 976 (83.8%) Table 2. Thrombophilia All patients (n=1165) Tested for individual thrombophilia % 95% CI % 95% CI FVL Heterozygous 162/1165 (13.9%) 12.0-16.0% 162/883 (18.4%) 15.9-21.0% FVL Homozygous 4/1165 (0.3%) 0.1-0.9% 4/883 (0.5%) 0.2-1.2% Prothrombin Heterozygous 63/1165 (5.4%) 4.3-6.9% 63/831 (7.6%) 6.0-9.6% Prothrombin Homozygous 1/1165 (0.0%) 0.0-0.5% 1/831 (0.1%) 0.0-0.7% Antithrombin deficiency 10/1165 (0.9%) 0.5-1.6% 10/815 (1.2%) 0.7-2.2% Protein C deficiency 18/1165 (1.6%) 1.0-2.4% 18/639 (2.8%) 1.8-4.4% Protein S deficiency 13/1165 (1.1%) 0.7-1.9% 13/635 (2.1%) 1.2-3.5% Lupus anticoagulant 24/1165 (2.1%) 1.4-3.1% 24/849 (2.8%) 1.9-4.2% Anticardiolipin IgM 16/1165 (1.4%) 0.9-2.2% 16/886 (1.8%) 1.1-2.9% Anticardiolipin IgG 20/1165 (1.7%) 1.1-2.6% 20/885 (2.2%) 1.5-3.5% β-2 microglobulin IgM 10/1165 (0.9%) 0.5-1.6% 10/333 (3.0%) 1.6-5.4% β-2 microglobulin IgG 8/1165 (0.7%) 0.4-1.4% 8/333 (2.4%) 1.2-4.7% Homocysteine 50/1165 (5.7%) 4.3-7.4% 50/668 (7.5%) 5.7-9.7% Factor VIII elevated 11/1165 (0.9%) 0.5-1.7% 11/646 (1.7%) 1.0-3.0% At least one or more of the above 331/1165 (28.4%) 25.9-31.1% 331/976 (33.9%) 31.0-36.9% Potent thrombophilia 103/1165 (8.8%) 7.34-10.6% 103/976 (10.6%) 9.6-14.5% Figure 1. Figure 1. Disclosures No relevant conflicts of interest to declare.
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Cozic, Solenn, Simon Boivinet, Christophe Pierre, Johan Boulet, Samuel Poulain, and Marcel Poulain. "Splicing fluoride glass and silica optical fibers." EPJ Web of Conferences 215 (2019): 04003. http://dx.doi.org/10.1051/epjconf/201921504003.
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Splicing fluoride glass fibers and silica fibers is a critical point for manufacturing all fibered laser modules. As these materials are extremely different, various problems must be considered: thermal, expansion, mechanical, chemical. Reliability and power handling make priority concerns. We report splices made on a 200/220 multimode silica fiber and a double clad 15/250/290 ZBLAN fiber. Splices are proof tested at 300 g tensile strength. No damage is observed after thermal cycling from -30 °C to 85 °C, at 40 % RH during 24 hours. Typical optical splice loss is about 0.2 dB. They withstand 220 W input power at 976 nm without any damage and drastic temperature increasing.
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Vojtěchovský, Jaroslav, Jindřich Hašek, Jiří Ječný, and Karel Huml. "The structure of 1,2,4,4,6-pentaphenyl-1,4-dihydropyridine." Collection of Czechoslovak Chemical Communications 55, no. 8 (1990): 2059–65. http://dx.doi.org/10.1135/cccc19902059.
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Title compound is triclinic, Mr = 461.60; P1, a = 9.158(1), b = 16.062(3), c = 19.472(3) Å, α = 110.69(1)°, β = 89.70(1)°, γ = 103.17(1)°, V = 2 600(1) Å3, Z = 4, Do = 1.15(3), Dc = 1.179(1) Mg m-3, λ(CuKα) = 1.5418 Å, μ = 0.509 mm-1, F(000) = 976 K, R = 0.040 for 8 059 unique observed reflections. Both symmetrically independent molecules show a different geometry of the 1,4-dihydropyridine ring: either the boat conformation with apexes C(sp3), N and boat angles 14.7(3)° and 10.3(2)° respectively, or the planar conformation. The conformation has been compared with similar dihydropyridines obtained from Cambridge Structural Database.
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Barraca, Jorge, Luis López Yarto, and Julio Olea. "Psychometric Properties of a New Family Life Satisfaction Scale." European Journal of Psychological Assessment 16, no. 2 (May 2000): 98–106. http://dx.doi.org/10.1027//1015-5759.16.2.98.
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Summary: A scale of bipolar adjectives, the Family Satisfaction by Adjectives Scale (F.S.A.S.), is presented, consisting of 27 items designed to measure family satisfaction, mainly related to the affective connotation derived from family interaction. After applying the scale to a sample of 274 subjects and 16 patients in family therapy, we obtained (a) acceptable indicators of internal consistency (α = .976) and temporal stability (rxx = 0.758), (b) clear evidence of unidimensionality, (c) significant linear correlations with other measures of family satisfaction (Family Satisfaction, Olson & Wilson, 1982 ; Family Satisfaction Scale, Carver, & Jones, 1992 ), and (d) significant differences between a normal sample and a clinical one.
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Umlauf, Sven, Markus Weber, and Robert Glaum. "Polymorphs of VO(PO3)2: synthesis and crystal structure refinement revisited." Zeitschrift für Kristallographie - Crystalline Materials 235, no. 8-9 (September 25, 2020): 303–9. http://dx.doi.org/10.1515/zkri-2020-0037.
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AbstractThe monoclinic α-polymorph of (VIVO)(PO3)2 is obtained reproducibly by reaction of V2O5 and H3PO4 (85%) (Au crucible, 380 °C, 4 d). Its crystal structure was refined from X-ray single-crystal data [C2/c, Z = 4, a = 15.1038(7) Å, b = 4.193(2) Å, c = 9.573(9) Å, β = 126.45(3), R1 = 0.052, wR2 = 0.189 for 976 unique reflections with Fo > 4σ(Fo), 48 variables]. A single-phase powder of the β-polymorph is obtained by the reaction of V2O5, H3PO4 (85%) and oxalic acid, evaporating the mixture, and subsequent annealing (porcelain crucible, 800 °C in air, 2 d). Single crystals of β-(VIVO)(PO3)2 were grown in a sealed silica ampoule with chlorine as mineralizer. The crystal structure of the orthorhombic (pseudo-tetragonal) β-polymorph was refined from X-ray single-crystal data [pseudo-merohedral twin, Fdd2, Z = 8, a = 15.536(2) Å, b = 15.586(2) Å, c = 4.2611(5) Å, R1 = 0.032, wR2 = 0.068 for 1072 unique reflections with Fo > 4σ(Fo), 50 variables]. Earlier reports on a tetragonal polymorph with unusual geometric structure of the [(V≡O)O5] polyhedron are corrected.
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Wei, Rongshan, Chu Chen, Cong Wei, Renping Wang, Lijie Huang, Qikun Zhou, and Wei Hu. "An Energy-Efficient Inverter-Based Voltage Reference Scheme with Wide Output Range Using Correlated Level Shifting Technique." Electronics 12, no. 24 (December 14, 2023): 5002. http://dx.doi.org/10.3390/electronics12245002.
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A voltage reference is indispensable in Integrated Circuits. To improve the limited linear output voltage range and energy efficiency of a voltage reference, we innovatively propose a switched-capacitor-based programmable voltage reference scheme employing inverter-based OTAs to reduce the power consumption, simultaneously using a novel Correlated Level Shifting (CLS) technique (without active overhead) to enhance the OTA’s DC gain and integral gain. Experimented with SMIC 180 nm CMOS technology, a scheme-based voltage reference realizes a programable output voltage range from 266 to 995 mV at −30 to 120 °C, and the corresponding temperature coefficient (TC) ranges from 82.4 to 99.5 ppm/°C. The power consumption is 976 nW. Furthermore, comparative experiments and evaluations with other schemes have unequivocally verified the superiority of our proposed scheme, characterized by its high energy efficiency and wide output voltage range. The scheme can be suitably deployed in a multitude of novel edge-data processing systems.
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Pujade-Lauraine, E., S. Mahner, J. Kaern, V. Gebski, M. Heywood, P. Vasey, A. Reinthaller, I. Vergote, S. Pignata, and A. Ferrero. "A randomized, phase III study of carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in relapsed platinum-sensitive ovarian cancer (OC): CALYPSO study of the Gynecologic Cancer Intergroup (GCIG)." Journal of Clinical Oncology 27, no. 18_suppl (June 20, 2009): LBA5509. http://dx.doi.org/10.1200/jco.2009.27.18_suppl.lba5509.
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LBA5509 Background: This multicenter phase III study was designed to compare efficacy and safety of carboplatin-pegylated liposomal doxorubicin (PLD) (C-D) and carboplatin-paclitaxel (C-P) in relapsed platinum-sensitive OC patients (pts). Methods: Pts with recurrent OC > 6 months after first-line or second-line platinum-based therapy who had been pretreated with a taxane were randomized by stratified blocks to either C-D [C AUC 5 IV + PLD 30 mg/m2 IV] d1 q4 wk, or C-P [C AUC 5 IV + P 175 mg/m2 IV] d1 q3 wk × ≥ 6 cycles. The primary endpoint was progression-free survival (PFS), with secondary endpoints of toxicity, QoL and survival. The non-inferiority design required 745 events with 90% power, 95% confidence interval (CI). Results: From 4/05 to 09/07, 976 pts were enrolled, 467 to C-D arm and 509 to C-P arm. Pt parameters were well balanced. 85% of C-D and 78% of C-P pts received ≥ 6 cycles. Median follow-up is 21mo. Overall survival is still too early to be reported (n=308 deaths). This is the final analysis for PFS and toxicity. Results are below. Conclusions: This trial, the largest in relapsed OC, showed significant superiority of PLD-carboplatin combination in terms of PFS. In addition, compared to paclitaxel-carboplatin, PLD-carboplatin was well tolerated with lower rates of severe and long-lasting (neuropathy) toxicities. [Table: see text] No significant financial relationships to disclose.
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Filócomo, Constanza. "El travestismo en Bacantes de Eurípides y su reformulación en algunas versiones contemporáneas." Cuadernos de Literatura, no. 18 (July 26, 2022): 43. http://dx.doi.org/10.30972/clt.0185990.
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<p>Bacantes de Eurípides (408 a. C.) ha despertado en las últimas décadas un especial interés, lo que se evidencia no solamente en las cuantiosas páginas que se han dedicado a comentarla, sino también en las numerosas versiones que fueron puestas en escena alrededor del mundo. Nos abocaremos a la escena de travestismo (vv. 912-976), que marca un quiebre en el argumento de la obra y que, además, ha sido particularmente debatida. En primer lugar, expondremos sucintamente algunas líneas de discusión de las que esta escena fue objeto y buscaremos acercarnos a la experiencia que habría propuesto Eurípides. Luego, analizaremos algunas de las numerosas propuestas performativas llevadas a cabo en los últimos años, para analizar de qué modo fue abordada e interpretada la escena que nos interesa.</p>
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Murin, L. I., J. Lennart Lindström, Bengt Gunnar Svensson, Vladimir P. Markevich, Anthony R. Peaker, and Charalamos A. Londos. "VOn (n≥3) Defects in Irradiated and Heat-Treated Silicon." Solid State Phenomena 108-109 (December 2005): 267–72. http://dx.doi.org/10.4028/www.scientific.net/ssp.108-109.267.
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Local vibrational mode (LVM) spectroscopy has been used to study the evolution of vacancy-oxygen-related defects (VOn) in the temperature range 300-700°C in carbon-lean Cz-Si samples irradiated with MeV electrons or neutrons. New experimental data confirming an attribution of the absorption bands at 910, 976 and 1105 cm-1 to the VO3 complex are obtained. In particular, a correlated generation of VO3 and the oxygen trimer is observed upon irradiation of Cz- Si crystals in the temperature range 300-400°C. Strong evidence for the assignment of the bands at 991 and 1014 cm-1 to a VO4 defect is presented. The lines are found to develop very efficiently in the VO2 containing materials enriched with the oxygen dimer. In such materials the formation of VO4 is enhanced due to occurrence of the reaction O2i+VO2 ⇒ VO4. Annealing of the VO3 and VO4 defects at T ≥ 550C °C is found to result in the appearance of new defects giving rise to a number of O-related LVM bands in the range 990-1110 cm-1. These bands are suggested to arise from VO5 and/or VO6 defects. Similar bands also appear upon the annihilation of oxygen-related thermal double donors at 650°C in Cz-Si crystals pre-annealed at 450°C.
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Zhang, Minghui, Haiqin Wen, Xiuhong Pan, Jianding Yu, Hui Shao, Fei Ai, Huimei Yu, Meibo Tang, and Lijun Gai. "Study on Upconversion and Thermal Properties of Tm3+/Yb3+ Co-Doped La2O3-Nb2O5-Ta2O5 Glasses." Materials 11, no. 8 (August 3, 2018): 1352. http://dx.doi.org/10.3390/ma11081352.
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The effect of Yb3+ ions on upconversion luminescence and thermal properties of Tm3+/Yb3+ co-doped La2O3-Nb2O5-Ta2O5 glasses has been studied. Glass transition temperature is around 740 °C, indicating high thermal stability. The effect of Yb3+ ions on the thermal stability is not obvious. Both the glass forming ability and the upconversion luminescence first increase and then decrease with the increase of Yb3+ ions. The glasses perform low glass forming ability with ΔT around 55 °C. Blue and red emissions centered around 477, 651, and 706 nm are obtained at the excitation of 976 nm laser. The upconversion luminescence mechanism is energy transfer from Yb3+ to Tm3+ mixed with two- and three- photon processes. The thermal kinetic Differential Thermal Analysis (DTA)-analysis indicates that the average activation energy first increases and then decreases with the increase of Yb3+ ions. This result can be introduced in order to improve upconversion luminescence of glasses by crystallization in the future. Tm3+/Yb3+ co-doped La2O3-Nb2O5-Ta2O5 glasses with good upconversion and thermal properties show promising applications in solid-state laser, optical temperature sensing.
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Farnham, Tony L., Michael S. P. Kelley, and James M. Bauer. "Early Activity in Comet C/2014 UN271 Bernardinelli–Bernstein as Observed by TESS." Planetary Science Journal 2, no. 6 (November 29, 2021): 236. http://dx.doi.org/10.3847/psj/ac323d.
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Abstract We used long duration observations from the Transient Exoplanet Survey Satellite (TESS) to investigate the behavior of comet C/2014 UN271 Bernardinelli–Bernstein at large heliocentric distances. By combining data from sector 03 (976 30 minute exposures from 2018), and sectors 29 and 30 (3585 and 3410 10 minute exposures, respectively, from 2020), we produced deep coadded images of the comet. A comparison of these results with similarly processed images of inactive Kuiper Belt objects and asteroids reveals that the comet was already exhibiting coma at heliocentric distances 23.8 and 21.2 au, making this one of the most distant comets for which preperihelion activity has been directly detected. A simple syndyne analysis of asymmetries in the coma suggests that activity probably started several years prior to these observations, and likely arose from emission in roughly the sunward direction. The images were used to produce photometric lightcurves, though no rotational variability was detected. We used NEOWISE observations from 2020 November 26–28 to place an upper limit of 2 × 1028 molecules s−1 (3σ) on the CO production rate.
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Maiwald, Martin, Heinar Schmidt, Bernd Sumpf, Reiner Güther, Götz Erbert, Heinz-Detlef Kronfeldt, and Günther Tränkle. "Microsystem Light Source at 488 nm for Shifted Excitation Resonance Raman Difference Spectroscopy." Applied Spectroscopy 63, no. 11 (November 2009): 1283–87. http://dx.doi.org/10.1366/000370209789806803.
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A microsystem light source emitting at 488 nm was tested and applied as a light source for shifted excitation resonance Raman difference spectroscopy (SERRDS). A nonlinear frequency conversion using a distributed feedback (DFB) diode laser emission at 976 nm and a periodically poled lithium niobate (PPLN) waveguide crystal was realized on a micro-optical bench with a footprint of 25 mm × 5 mm. Joint temperature management via the microbench is used for wavelength tuning. Two emission lines at 487.61 nm and 487.91 nm are used for the SERRDS experiments. The Raman spectra of the test sample polystyrene demonstrate that a laser bandpass filter did not need to be implemented. Resonance Raman spectra of Tartrazine (FD&C Yellow 5, E 102) in distilled water are presented to demonstrate the suitability of this light source for SERRDS in, e.g., food safety control.
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Wang, Perona, Schmidt-RioValle, Chen, Jing, and González-Jiménez. "Metabolic Syndrome and Its Associated Early-Life Factors among Chinese and Spanish Adolescents: A Pilot Study." Nutrients 11, no. 7 (July 11, 2019): 1568. http://dx.doi.org/10.3390/nu11071568.
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Metabolic syndrome (MetS) is a growing problem worldwide in adolescents. This study compared two sample populations of young people in Spain and China, and analyzed the association of birth weight and breastfeeding duration with MetS. A cross-sectional study was conducted in adolescents (10–15 years old); 1150 Chinese and 976 Spanish adolescents. The variables analyzed were anthropometric characteristics, biochemical markers, and demographic characteristics using the same methodology and data collection protocol. Also, birth weight and breastfeeding were retrospectively analyzed during the first year of life. The results showed statistically significant differences between the two groups in reference to body mass index (BMI), blood pressure, triglyceride, glucose, and high-density lipoprotein cholesterol (HDL-C) levels. The MetS prevalence was higher in Spanish adolescents (2.5%) than in the Chinese group (0.6%). Breastfeeding duration was inversely associated with hypertriglyceridemia, low HDL-C, and MetS, whereas higher birth weight was associated with hyperglycemia, low HDL-C, hypertriglyceridemia, and abdominal obesity. Spanish adolescents showed more altered MetS components, and consequently, a higher MetS prevalence than the Chinese adolescents. This made them more vulnerable to cardiometabolic risk. Our results highlight the need for interventions designed by health professionals, which would encourage pregnant women to breastfeed their children.
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Trewhella, M., and D. Jones. "Percutaneous nephrostomy to relieve renal tract obstruction in pregnancy." British Journal of Radiology 64, no. 766 (October 1991): 976–77. http://dx.doi.org/10.1259/0007-1285-64-766-976-c.
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Thompson, Alexander M. W. Cargill, Stuart R. Batten, John C. Jeffery, Leigh H. Rees, and Michael D. Ward. "Some Coordination Chemistry of the Bidentate Nitrogen-Donor Ligand 2-(2-Aminophenyl)pyridine." Australian Journal of Chemistry 50, no. 2 (1997): 109. http://dx.doi.org/10.1071/c96146.
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Complexes of the chelating bidentate nitrogen-donor ligand 2-(2-aminophenyl)pyridine (L) are described. [PdL2] [PF6]2 (1) forms two types of crystal (1a,b) of which (1a) was crystallographically characterized [space group P 21/c a 10·974(6), b 14·757(4), c 8·223(2) Å; β 104·66(5)°; V 1288·3(8) Å3; Z 2]. It has a square-planar donor set about the metal, with the ligands mutually trans and with a twist of 35° between the pyridyl and phenyl rings. 1 H n.m.r. spectroscopy shows that pure (1a) and (1b) equilibrate in solution; it is likely that (1b) is thecis form of the complex. Electrochemical measurements on [Ru(bipy)2L] [PF6]2 (2) show that the RuII /RuIIIcouple is cathodically shifted by 0·34 V with respect to [Ru(bipy)3]2+ , indicating that replacing a pyridyl donor by an amine results in a significant increase of electron density on the metal centre: this effect is much larger with a primary amine ligand than with tertiary amines. The e.p.r. spectrum of [CuL2] [PF6]2 (3) shows that a small extent of association into a dinuclear complex occurs, a reaction which is solvent-dependent: addition of pyridine breaks up the dimer by coordination to the axial sites of the monomer, whose spectrum is characteristic of a tetragonal geometry (i.e. a planar array of two ligands L, and axial solvent molecules). Attempted recrystallization of other complexes of L from acetone afforded [C14H15N2] [PF6] (4), in which the free ligand L has condensed with acetone and then undergone an intramolecular cyclization by attack of the pyridyl nitrogen atom on the electrophilic carbon atom of the imine bond; this compound was also crystallographically characterized [space group P 21/n; a 8·258(2), b 10·036(4), c 17·976(7) Å; β 100·12(3)°; V 1466·8(10) Å3 ; Z 4]
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Miyazaki, Seiichi, and Katsunori Makihara. "(Invited) Formation and Characterization of Fe-Silicide Nanodots for Optoelectronic Application." ECS Transactions 112, no. 1 (September 29, 2023): 131–37. http://dx.doi.org/10.1149/11201.0131ecst.
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We have demonstrated the formation of high areal-density β-FeSi2nanodots (NDs) on SiO2 by remote H2-plasma induced self-assembly of Fe-NDs and subsequent SiH4-exposure at 400°C. Under either 976- or 514.5-nm light excitation of NDs after the SiH4-exposure, stable photoluminescence (PL) signals, being characteristic of the semiconducting phase as β-FeSi2, were observed even at room temperature in the energy region over the indirect bandgap of bulk β-FeSi2 (~0.7 eV). The temperature dependence of PL was confirmed to be weak significantly in comparison to that of bulk bandgap, implying light emission from tightly confined NDs. And also, with a decrease in the average dot size by controlling the initial Fe-film thickness, a clear blue shift in PL was observed. The results are associated with quantum size effect in radiative recombination of photoexcited electron-hole pairs.
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Abubakar, M., L. G. Hassan, N. A. Sani, N. Aminu, and S. Yahaya. "Preparation and Characterization of Chitosan from Schistocerca Gregaria (Desert Locust)." International Journal of Science for Global Sustainability 9, no. 3 (October 31, 2023): 14–20. http://dx.doi.org/10.57233/ijsgs.v9i3.524.
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The current study prepared and characterized chitosan from Schistocerca gregaria (Desert Locust) by a chemical method. The Schistocerca gregaria (Desert Locust) chitin and chitosan have yield of 42% and 43% with acceptable physicochemical properties such as Moisture content: 6.0±0.014 and 5.0±0.007 %, Ash content: 2.20 and 2.0%, Protein content 12.0±0.028 and 9.01 ±0.021, Crude fibre8.95±0.041 and 8.95 ± 0.014%, Lipid content, 10.0 ±0.014 and10.0 ±0.014%, however, high carbohydrate, 60.5±0.01 and 65.0±0.01% are quantified in the obtained chitin and chitosan. properties of chitosan prepared were compared with that of the other sources chitosan extracted, the study revealed that (FTIR) analysis confirmed the structure of chitosan by the presence of their characteristic IR bands such as the N–H and O–H stretching bands around 3630 cm−1, oxygen stretching (C-O-C) glycosidic linkage bands around 1125 cm−1, (C-O) in primary OH group bands around 976 cm−1, and 1634 cm−1 corresponding to the free amino group (−NH2) at C2 of glucosamine with 69% degree of deacetylation. Also, the obtained XRD peaks were around 19.01, and 20.48◦ which indicated the amophores structure. This indicates the successive formation of chitosan biopolymer. Therefore, the Schistocerca gregaria chitosan can be said to be of better quality and hence can replace commercial chitin and chitosan in terms of utilization and applications.
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Hasanah, Novia Tri, Irna Sufiawati, Adji Kusumadjati, and Mas Adi Sunardi. "In Vitro Effect of Low-level Laser Therapy on Candida albicans Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer." Journal of Lasers in Medical Sciences 15 (May 8, 2024): e11. http://dx.doi.org/10.34172/jlms.2024.11.
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Introduction: Studies on head and neck cancer (HNC) patients undergoing radiotherapy have revealed increased numbers of Candida spp., leading to oral candidiasis and oral mucositis. The effects of laser therapy on Candida spp. have been studied with varied results. This study aimed to investigate the effect of low-level laser therapy (LLLT) on C. albicans colonies isolated from HNC patients undergoing radiotherapy. Methods: This study included a treated group, wherein 11 C. albicans isolates were obtained from the saliva of HNC patients undergoing radiotherapy at a dose exceeding 30 Gy. The control groups consisted of an untreated negative control and a positive control treated with nystatin. The treatment groups were subjected to LLLT in continuous mode for 50 seconds at a wavelength of 976 nm, 0.1 W at a dose of 5 J/cm2 for Laser 1 (L1) group and 0.2 W at a dose of 10 J/cm2 for Laser 2 (L2) group. The tests were conducted using C. albicans inoculum equivalent to a 0.5-McFarland suspension on 96-well plates. All test group inoculums were then cultured on Sabouraud dextrose agar (SDA), and the colony count was assessed at 104 CFU/mL. Results: LLLT at 5 and 10 J/ cm2 reduced C. albicans colonies by 7.01% and 10.94%, respectively, but the reductions were not statistically significant (P>0.05). Nystatin eliminated all the colonies. Conclusion: LLLT shows potential for reducing C. albicans colonies in HNC patients undergoing radiotherapy. However, further studies with varied parameters and methods are necessary.
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Roshdy, Wael H., Mohamed K. Khalifa, James Emmanuel San, Houriiyah Tegally, Eduan Wilkinson, Shymaa Showky, Darren Patrick Martin, et al. "SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic." Viruses 14, no. 9 (August 25, 2022): 1878. http://dx.doi.org/10.3390/v14091878.
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COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part of the national genomic surveillance, 1027 SARS-CoV-2 near whole-genomes were generated and published by the end of July 2021. Here we describe the genomic epidemiology of SARS-CoV-2 in Egypt over this period using a subset of 976 high-quality Egyptian genomes analyzed together with a representative set of global sequences within a phylogenetic framework. A single lineage, C.36, introduced early in the pandemic was responsible for most of the cases in Egypt. Furthermore, to remain dominant in the face of mounting immunity from previous infections and vaccinations, this lineage acquired several mutations known to confer an adaptive advantage. These results highlight the value of continuous genomic surveillance in regions where VOCs are not predominant and the need for enforcement of public health measures to prevent expansion of the existing lineages.
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Prasanth, M., N. Ravi, K. Thyagarajan, and K. Venkata Krishnaiah. "Thermal and structural studies of Bismuth Borate glasses modified with Gadolinium Oxide for solid state lighting applications." IOP Conference Series: Materials Science and Engineering 1233, no. 1 (March 1, 2022): 012002. http://dx.doi.org/10.1088/1757-899x/1233/1/012002.
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Abstract Bismuth based borate glasses with combination B2O3 –Bi2O3 – Gd2O3 - K2O-Li2O (BBiGdKLi) were prepared by melt-quenching method at 1250 °C for thermal and structural properties investigation.. Glass transition temperature (Tg) was observed at 681 K in heat capacity (Cp) vs temperature plot. As the temperature increases the specific heat or heat capacity also increases but a sudden fall in Cp was noticed at 962 K which is known to be crystalline temperature (Tc) of BBiGdKLi glass. Borate units comprising non-bridging oxygen (NBO) such as υ(B-O-Gd/Bi/K/Li) occured due to asymmetric stretching vibration at 976 cm-1 revealed in Raman spectrum excited by 532 nm laser. B1s, Bi 4f and Gd 4d binding energies from the XPS spectra of BBiGdKLi glass are corresponding to 188.9, 156.35 & 161.75 and 156.35 & 161.7 eV, respectively. The thermal behavior of BBiGdKLi glass suggest that these glasses could be significant materials for solid state lighting applications.
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Mărginean, Cristina Oana, Claudiu Mărginean, Septimiu Voidăzan, Lorena Meliţ, Andrei Crauciuc, Carmen Duicu, and Claudia Bănescu. "Correlations Between Leptin Gene Polymorphisms 223 A/G, 1019 G/A, 492 G/C, 976 C/A, and Anthropometrical and Biochemical Parameters in Children With Obesity." Medicine 95, no. 12 (March 2016): e3115. http://dx.doi.org/10.1097/md.0000000000003115.
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GRANDE, MARIA J., ROSARIO LUCAS, EVA VALDIVIA, HIKMATE ABRIOUEL, MERCEDES MAQUEDA, NABIL BEN OMAR, MAGDALENA MARTÍNEZ-CAÑAMERO, and ANTONIO GÁLVEZ. "Stability of Enterocin AS-48 in Fruit and Vegetable Juices." Journal of Food Protection 68, no. 10 (October 1, 2005): 2085–94. http://dx.doi.org/10.4315/0362-028x-68.10.2085.
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Enterocin AS-48 is a candidate bacteriocin for food biopreservation. Before addressing application of AS-48 to vegetable-based foods, the interaction between AS-48 and vegetable food components and the stability of AS-48 were studied. Enterocin AS-48 had variable interactions with fruit and vegetable juices, with complete, partial, or negligible loss of activity. For some juices, loss of activity was ameliorated by increasing the bacteriocin concentration, diluting the juice, or applying a heat pretreatment. In juices obtained from cabbage, cauliflower, lettuce, green beans, celery, and avocado, AS-48 was very stable for the first 24 to 48 h of storage under refrigeration, and decay of activity was markedly influenced by storage temperature. In fresh-made fruit juices (orange, apple, grapefruit, pear, pineapple, and kiwi) and juice mixtures, AS-48 was very stable for at least 15 days at 4°C, and bacteriocin activity was still detectable after 30 days of storage. Gradual and variable loss of activity occurred in juices stored at 15 and 28°C; inactivation was faster at higher temperatures. In commercial fruit juices (orange, apple, peach, and pineapple) stored at 4°C, the bacteriocin was completely stable for up to 120 days, and over 60% of initial activity was still present in juices stored at 15°C for the same period. Commercial fruit juices stored at 28°C for 120 days retained between 31.5% (apple) and 67.71% (peach) of their initial bacteriocin activity. Solutions of AS-48 in sterile distilled water were stable (120 days at 4 to 28°C). Limited loss of activity was observed after mixing AS-48 with some food-grade dyes and thickening agents. Enterocin AS-48 added to lettuce juice incubated at 15°C reduced viable counts of Listeria monocytogenes CECT 4032 and Bacillus cereus LWL1 to below detection limits and markedly reduced viable counts of Staphylococcus aureus CECT 976.
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Koola, Jejo David, Samuel Ho, Guanhua Chen, Amy M. Perkins, Aize Cao, Sharon E. Davis, and Michael E. Matheny. "Development of a national Department of Veterans Affairs mortality risk prediction model among patients with cirrhosis." BMJ Open Gastroenterology 6, no. 1 (November 2019): e000342. http://dx.doi.org/10.1136/bmjgast-2019-000342.
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ObjectiveCirrhotic patients are at high hospitalisation risk with subsequent high mortality. Current risk prediction models have varied performances with methodological room for improvement. We used current analytical techniques using automatically extractable variables from the electronic health record (EHR) to develop and validate a posthospitalisation mortality risk score for cirrhotic patients and compared performance with the model for end-stage liver disease (MELD), model for end-stage liver disease with sodium (MELD-Na), and the CLIF Consortium Acute Decompensation (CLIF-C AD) models.DesignWe analysed a retrospective cohort of 73 976 patients comprising 247 650 hospitalisations between 2006 and 2013 at any of 123 Department of Veterans Affairs hospitals. Using 45 predictor variables, we built a time-dependent Cox proportional hazards model with all-cause mortality as the outcome. We compared performance to the three extant models and reported discrimination and calibration using bootstrapping. Furthermore, we analysed differential utility using the net reclassification index (NRI).ResultsThe C-statistic for the final model was 0.863, representing a significant improvement over the MELD, MELD-Na, and the CLIF-C AD, which had C-statistics of 0.655, 0.675, and 0.679, respectively. Multiple risk factors were significant in our model, including variables reflecting disease severity and haemodynamic compromise. The NRI showed a 24% improvement in predicting survival of low-risk patients and a 30% improvement in predicting death of high-risk patients.ConclusionWe developed a more accurate mortality risk prediction score using variables automatically extractable from an EHR that may be used to risk stratify patients with cirrhosis for targeted postdischarge management.
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Funston, Alison M., Robert W. Gable, W. David McFadyen, and Peter A. Tregloan. "The Preparation of a Mixed-Ligand Cobalt(III) Complex of DPPZ and Ethylenediamine: Crystal Structures of [Co(en)2(DPPZ)] (ClO4)3.0·5H2O, [Co(en)2(bpy)]Br(ClO4)2 and [Co(en)2(phen)] Br3." Australian Journal of Chemistry 52, no. 8 (1999): 817. http://dx.doi.org/10.1071/ch99060.
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The complex [Co(en)2(DPPZ)] (ClO4)3 (3) has been synthesized, and the crystal structures of this complex and those of [Co(en)2(bpy)] Br(ClO4)2 (1) and [Co(en)2(phen)] Br3 (2) have been determined. Crystal data for (1): M 614 . 13, monoclinic, space group C2/c (No. 15), a 16 . 7834(16), b 16 . 308(3), c 8 . 3167(15) Å, β 104 . 932(11)°, V 2199 . 4(6) Å, F(000) 1240, Z 4, Dc 1 . 855 g cm−3, µ 2 . 895 cm−1 , Mo Kα (graphite monochromatized) radiation, γ 0 . 71073 Å, T 293(1) K. Crystal data for (2): M 599 . 07, triclinic, space group P1 (No. 2), a 7 . 7113(11), b 10 . 633(2), c 12 . 9884(18) Å, α 85 . 745(15), b 78 . 258(11), γ 74 . 967(16)°, V 1006 . 7(3) Å, F(000) 588, Z 2, Dc 1 . 976 g cm−3, µ6 . 819 cm−1 , MoKα (graphite monochromatized) radiation, γ 0 . 71073 Å, T 293(1) K. Crystal data for (3): M 773 . 44, monoclinic, space group P 21/c (No. 14), a 20 . 296(2), b 9 . 6197(11), c 15 . 725(2) Å, β 92 . 850(10)°, V 3066 . 4(6) Å, F(000) 1579, Z 4, Dc 1 . 675 g cm−3 , µ 0 . 898 cm−1 , MoKα(graphite monochromatized) radiation, γ 0 . 71073 Å, T 293(1) K. In all three complexes the cobalt is in the usual octahedral environment, with the cations being linked by hydrogen bonds between the amine hydrogens and the anions into extended structures.
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Chrzanowska - Steglińska, Marta, Hanna Moczulska, Beata Skoczylas, Michał Pietrusiński, Karolina Antosik, Paulina Jakiel, Marta Kacprzak, Maciej Borowiec, and Piotr Sieroszewski. "Occurrence of c.976 G>T (p.Val326Leu) and c.452 G>A (p.Trp151Ter) variants in DHCR7 gene in population of polish women with recurrent miscarriage." European Journal of Obstetrics & Gynecology and Reproductive Biology 252 (September 2020): 252–55. http://dx.doi.org/10.1016/j.ejogrb.2020.05.063.
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Mokhtar, M. "Surface and Catalytic Properties of the CuO/Al2O3 System as Influenced by Treating with Trace Amounts of MoO3." Adsorption Science & Technology 21, no. 5 (June 2003): 425–38. http://dx.doi.org/10.1260/026361703769645762.
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A CuO/Al2O3 solid containing 0.2 mol% CuO (0.2CuO/Al2O3) and three MoO3-doped variants of this material were all prepared via the wet impregnation method, the amount of dopant added to the CuO/Al2O3 solid being 0.25, 1.0 or 2.0 mol% MoO3, respectively. All the samples prepared were heated in air to 350, 450 or 600°C, respectively, before being cooled to room temperature and stored. X-Ray studies of these materials showed that the undoped (pure) solid calcined at 350°C exhibited all the diffractions lines associated with the AlO(OH) and CuO phases with an excellent degree of crystallinity. Doping the pure solid resulted in the effective progressive decrease in the degree of crystallinity of both the above-mentioned phases to an extent proportional to the amount of dopant added. Increasing the calcination temperature of the pure and doped solids to 650°C led to a significant decrease in the degree of ordering of CuO due to the formation of poorly crystalline γ-Al2O3 having a much better dispersion power relative to AlO(OH). The specific surface areas of the various samples were found to decrease progressively as the amount of dopant added was increased, especially for samples calcined at 650°C. Increasing the calcination temperature of the pure sample within the range 350–650°C led to a small increase in their catalytic activities in H2O2 decomposition. In contrast, MoO3 treatment followed by calcination of the resulting materials in the range 350–650°C resulted in a significant increase in their catalytic activities in the same catalytic reaction. The maximum increase in the catalytic activity at 30°C attained values of 720%, 735% and 976% for the doped solids calcined at 350, 450 and 650°C, respectively. In contrast, however, such doping brought about a progressive measurable decrease in the catalytic activity of the treated solids towards CO oxidation by O2 when this latter reaction was conducted over the temperature range 150–250°C.
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Thiem, Jonas, Simon Spelthann, Laurie Neumann, Florian Jakobs, Hans-Hermann Johannes, Wolfgang Kowalsky, Dietmar Kracht, Joerg Neumann, Axel Ruehl, and Detlev Ristau. "Upconversion Nanocrystal Doped Polymer Fiber Thermometer." Sensors 20, no. 21 (October 24, 2020): 6048. http://dx.doi.org/10.3390/s20216048.
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In recent years, lanthanide-doped nanothermometers have been mainly used in thin films or dispersed in organic solvents. However, both approaches have disadvantages such as the short interaction lengths of the active material with the pump beam or complicated handling, which can directly affect the achievable temperature resolution. We investigated the usability of a polymer fiber doped with upconversion nanocrystals as a thermometer. The fiber was excited with a wavelength stabilized diode laser at a wavelength of 976 nm. Emission spectra were recorded in a temperature range from 10 to 35 ∘C and the thermal emission changes were measured. Additionally, the pump power was varied to study the effect of self-induced heating on the thermometer specifications. Our fiber sensor shows a maximal thermal sensitivity of 1.45%/K and the minimal thermal resolution is below 20 mK. These results demonstrate that polymer fibers doped with nanocrystals constitute an attractive alternative to conventional fluorescence thermometers, as they add a long pump interaction length while also being insensitive to strong electrical fields or inert to bio-chemical environments.
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Lundén, Arnold. "Internal Cation Mobilities and their Isotope Effects in the Molten System (Li, K)Cl." Zeitschrift für Naturforschung A 41, no. 8 (August 1, 1986): 1034–40. http://dx.doi.org/10.1515/zna-1986-0811.
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With the Klemm method, the internal m obility ratios of the Li and K. 6Li and 7Li, and 39K and 41K have been measured for melts o f the system (Li. K)Cl near the eutectic composition (ca. 56% Li) in the range 729 -976 K. Under all these conditions the Chemla effect occurs, i.e. bLi<bK. (b- internal mobility). In the region near the anode the com position becomes that corresponding to the Chemla crossing point, which shifts with temperature toward higher concentration of Li+. Both bLi and bK have been found to be well expressed by the equation b = [A/( V - V0)] exp ( - E/RT ) (V: molar volum e. A and E: constants depending on the respective cation. V0: a parameter depending on the respective cation and temperature), which is also valid for the mobilities in alkali nitrates when the C oulom bic attraction plays a dominant role. The isotope effects o f both cations seem to be similar to those in pure LiCl and KCl and slightly increase with temperature.
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Luis Francisco, Cristovao Teixeira, Ruth Hernández Vital, and Jair Arody Del Valle López. "Validación de instrumentos de medición para las variables conocimiento, convicción y compromiso de los padres respecto de un sistema educativo confesional." RIEE | Revista Internacional de Estudios en Educación 22, no. 2 (October 25, 2022): 83–100. http://dx.doi.org/10.37354/riee.2022.223.
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El propósito de este estudio fue diseñar y validar instrumentos de medición para las variables conocimiento, convicción y compromiso de los padres respecto de un sistema educativo confesional. A través de un muestreo no probabilístico por conveniencia, se realizó una prueba piloto donde fueron seleccionados 101 padres, con hijos en edad escolar de nivel primario y medio en escuelas que pertenecen a una sección del noreste de México. Para los análisis estadísticos se usó el análisis factorial exploratorio, con una extracción de factorización de ejes principales y una rotación equamax. Al analizar los resultados del estudio, se determinó que los tres instrumentos refieren una varianza explicada aceptable: (a) conocimiento (σ2 = 76.38%), (b) convicción (σ2 = 83.35%) y (c) compromiso (σ2= 65.08%). El coeficiente de confiabilidad, medido por el alfa de Cronbach, reveló un elevado grado de consistencia interna total para las variables convicción (α = .976), conocimiento (α = .969) y compromiso (α = .889). Como conclusión, se infiere que los instrumentos propuestos son válidos para valorar el grado de conocimiento, convicción y compromiso por parte de los padres respecto de un sistema educativo confesional.
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Govind, Mukesh Kumar, Manish Kumar, Hardeep, and Deepak Sangwan. "Effect of seed priming on germination parameters of Bael (Aegle marmelos Corr.) under laboratory conditions." Environment Conservation Journal 25, no. 1 (February 7, 2024): 199–205. http://dx.doi.org/10.36953/ecj.24392668.
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The current experiment was conducted during 2020-21 at the Microbiology Laboratory, CCS Haryana Agricultural University, Regional Research Station Bawal to examine the impact of bio-inoculants and chemicals seed priming on bael seed germination. There were 15 seed priming treatments i.e., control, IBA @ 100 ppm and 50 ppm for 24 hours, NAA @ 50 and 100 ppm for 24 hours, GA3 @ 50 and 100 ppm for 24 hours, KNO3 @ 1 per cent for 24 hours, Azotobacter (HT 54) for 30 minutes, Trichoderma viride for 30 minutes, Rhizobium (CK 16) for 30 minutes, PSB (P 36) for 30 minutes, hot water for 30 minutes, nitric acid for 3 minutes, sulphuric acid for 3 minutes. Among different seed priming treatments, shortest germination time (12.7 days) was recorded with sulphuric acid for 3 minutes in agar medium at 28 ⁰C under laboratory conditions and the highest germination percentage (83.3 %), dry weight per seedling (153.2 mg), seedling length (12.2 cm) and vigour index I (976) and II (12256) were observed when bael seeds primed with GA3 @ 100 ppm for 24 hours under laboratory conditions.
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Lin, L. S., G. W. Levan, S. M. Russell, and C. C. Law. "Effect of titanium addition on a Ni-Al-Co alloy." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 4 (August 1990): 938–39. http://dx.doi.org/10.1017/s0424820100177829.
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AEM examinations of a NiAlCo alloy of composition Ni-29 at.% Al-21 at.% Co after room temperature compression show that the microstructure consists of a twinned tetragonal matrix (L10, marked A in Figure 1a) and ordered fcc gamma prime precipitates (L12, marked B in Figure 1a) along grain boundaries. The compressive yield strengths of this alloy at room temperature and 760°C are 754 MPa and 163 MPa respectively. It also has superior room temperature ductility as compared to binary NiAl. An addition of 5 at.% Ti at the expense of Ni was made to this alloy in order to increase the yield strengths. The quarternary alloy shows compressive yield strengths of 976 MPa and 403 MPa at room temperature and 760°C, respectively, indicating that the Ti addition is having the desired effect.Comparison of the microstructures of the two alloys after room temperature compression (Figures la and lb) shows that the Ti containing alloy has a smaller grain size. X-ray diffraction data indicate that the gamma prime volume fraction increases from 10% to 20% as the result of the Ti addition. Titanium was also found to stabilize the B2 matrix (marked A in Figure lb) as no tetragonal L10 phase was found. All precipitates along grain boundaries were identified by micro-diffraction to be gamma prime.
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Baek, Dooyoung, Kyeng-Bo Sim, and Hyun-Joong Kim. "Mechanical Characterization of Core-Shell Rubber/Epoxy Polymers for Automotive Structural Adhesives as a Function of Operating Temperature." Polymers 13, no. 5 (February 27, 2021): 734. http://dx.doi.org/10.3390/polym13050734.
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Automotive structural adhesives must show a steady toughness performance in the temperature range of −40 °C to 80 °C, considering their actual usage environments. Core-shell rubber (CSR) nanoparticles are known to enhance the toughness of epoxy systems. In this study, a CSR, pre-dispersed, diglycidyl epoxy of bisphenol A (DGEBA) mixture at 35 wt % (KDAD-7101, Kukdo Chemical, Seoul, Korea) was used as a toughener for an automotive structural epoxy adhesive system. A simple, single-component, epoxy system of DGEBA/dicyandiamide with a latent accelerator was adopted, where the CSR content of the system was controlled from 0 to 50 phr by the CSR mixture. To determine the curing conditions, we studied the curing behavior of the system by differential scanning calorimetry (DSC). Modulus variations of the cured bulk epoxies were studied using a dynamic mechanical analyzer (DMA) in the dual cantilever mode. The flexural modulus of the cured epoxies at various temperatures (−40, −10, 20, 50, and 80 °C) showed the same tendency as the DMA results, and as the flexural strength, except at 0 phr. On the other hand, the strain at break exhibited the opposite tendency to the flexural modulus. To study the adhesion behavior, we performed single-lap joint (SLJ) and impact wedge-peel (IWP) tests. As the CSR content increased, the strength of the SLJ and dynamic resistance to the cleavage of the IWP improved. In particular, the SLJ showed excellent strength at low temperatures (32.74 MPa at 50 phr @ −40 °C (i.e., an 190% improvement compared to 17.2 MPa at 0 phr @ −40 °C)), and the IWP showed excellent energy absorption at high temperatures (21.73 J at 50 phr @ 80 °C (i.e., a 976% improvement compared to 2.07 J at 0 phr @ 80 °C)). The results were discussed in relation to the changes in the properties of the bulk epoxy depending on the temperature and CSR content. The morphology of the fracture surface was also provided, which offered useful information for composition studies using the CSR/epoxy system.
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Almind, Gitte Juul, A. Abraham-Zadeh, E. Faerch, F. Lindenberg, S. Smidt-Jensen, and S. Lindenberg. "Two modified natural in vitro fertilisation (IVF) protocols compared to conventional IVF treatment: Retrospective data from one Danish Fertility Centre." Obstetrics & Gynecology International Journal 12, no. 6 (December 2, 2021): 386–89. http://dx.doi.org/10.15406/ogij.2021.12.00610.
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Aim of study: Over the last decade, laboratory procedures in in vitro fertilisation (IVF) have improved. Hyperstimulated ovaries cause an overload of surplus embryos. The present study was designed to evaluate the efficiency of two different modified IVF cycle protocols trying to reduce the load of medication used for IVF: simple IVF (S-IVF), Tamoxifen 40 mg daily from day 2 in the cycle to ovulation induction) and mild IVF (M-IVF), Tamoxifen 40 mg daily and every secondary 150 IU Gonal F until ovulation induction. The study aims to evaluate their efficiency compared with our conventional IVF (C-IVF) using a short antagonist protocol. Methods: A retrospective cohort study including all patients admitted to IVF for unexplained infertility, tubal factor, and male factor. In all stimulated cycles patients aimed at having fresh embryos transferred and surplus good embryos cryopreserved. All patients were recruited in the same period and allocated to the different treatments on their own request. The study was conducted between June 2019 and February 2021. Results: In total the study included 976 IVF cycles. 651 cycles from C-IVF, 145 cycles from S-IVF and 180 cycles from M-IVF. Mean age in the groups were comparable. Mean number of eggs retrieved was 6.1 (C-IVF), 1.2 (S-IVF) and 3.0 (M-IVF). Pregnancy rate per fresh transfer was found to be 29% for C-IVF, 26% in the S-IVF group and for the M-IVF 20%. Conclusion: Modified IVF stimulation protocols may be an important step towards a simpler assisted reproductive technology (ART) approach. More tolerable for women, easier and cheaper for patients and society they maintain acceptable clinical pregnancy rates. Large prospective studies need to be performed in the future.
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Benito, Pedro J., Laura M. Bermejo, Ana B. Peinado, Bricia López-Plaza, Rocío Cupeiro, Barbara Szendrei, Francisco J. Calderón, Eliane A. Castro, and Carmen Gómez-Candela. "Change in weight and body composition in obese subjects following a hypocaloric diet plus different training programs or physical activity recommendations." Journal of Applied Physiology 118, no. 8 (April 15, 2015): 1006–13. http://dx.doi.org/10.1152/japplphysiol.00928.2014.
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The aim of the present study was to compare the effects of different physical activity programs, in combination with a hypocaloric diet, on anthropometric variables and body composition in obese subjects. Ninety-six obese (men: n = 48; women: n = 48; age range: 18-50 yr) participated in a supervised 22-wk program. They were randomized into four groups: strength training (S; n = 24), endurance training (E; n = 26), combined strength + endurance training (SE; n = 24), and physical activity recommendations (C; n = 22). In addition, all groups followed the same hypocaloric diet. At baseline and at the end of the intervention, dietetic and physical activity variables were assessed using validated questionnaires. Anthropometric variables were recorded along with body composition variables measured using dual-energy X-ray absorptiometry techniques. At the end of the intervention, significant improvements were seen within groups in terms of body weight (S: −9.21 ± 0.83 kg; E: −10.55 ± 0.80 kg; SE: −9.88 ± 0.85 kg; C: −8.69 ± 0.89 kg), and total fat mass (S: −5.24 ± 0.55%; E: −5.35 ± 0.55%; SE: −4.85 ± 0.56%; C: −4.89 ± 0.59%). No differences were seen between groups at this time in terms of any other anthropometric or body composition variables examined. All groups increased their total physical activity in metabolic equivalents (MET) per week during the intervention, but with no difference between groups (S: 976 ± 367 MET-min/wk; E: 954 ± 355 MET-min/wk; SE: 1 329 ± 345 MET-min/wk; C: 763 ± 410 MET-min/wk). This study shows that, when combined with a hypocaloric diet, exercise training and adherence to physical activity recommendations are equally effective at reducing body weight and modifying body composition in the treatment of obesity (Clinical Trials Gov. number: NCT01116856).
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Zhu, Wenjuan, Yagang Zhang, Penglei Wang, Zhiyong Yang, Akram Yasin, and Letao Zhang. "Preparation and Applications of Salt-Resistant Superabsorbent Poly (Acrylic Acid-Acrylamide/Fly Ash) Composite." Materials 12, no. 4 (February 16, 2019): 596. http://dx.doi.org/10.3390/ma12040596.
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Solution polymerization synthesized alt-resistant superabsorbent poly (acrylic acid-acrylamide/fly ash) composites. The mass ratio of acrylic acid (AA) to acrylamide (AM), the concentration of crosslinker, the neutralization degree (ND) of AA, and the polymerization temperature were investigated by single-factor method. Optimized conditions for the synthesis of poly (acrylic acid-acrylamide/fly ash) (PAA-AM/FA) are, as following: m (AA)/m (AM) is 1.5, the content of crosslinker N, N-methylenebisacrylamide. (MBA) is 0.7%, neutralization degree of AA is 70%, polymerization temperature is 70 °C, and fly ash (FA) content is 50%. The prepared PAA-AM/FA demonstrated superior water absorption performance. The absorption capacities of PAA-AM/FA for pure water and 0.9% NaCl solution were found to be 976 g·g−1 and 81 g·g−1, respectively. Furthermore, PAA-AM/FA was found to have excellent adsorption capacity (148 mg·g−1) for Rhodamine B in water. Fourier Transform-Infrared Spectroscopy (FT-IR), Thermogravimetric Analysis (TGA), and Scanning Electron Microscopy (SEM) characterized the prepared materials. Results showed that fly ash was incorporated into the macromolecular polymer matrix and played a key role in improving the performance of the polymer composites.
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Chandonia, John-Marc, Lindsey Guan, Shiangyi Lin, Changhua Yu, Naomi K. Fox, and Steven E. Brenner. "SCOPe: improvements to the structural classification of proteins – extended database to facilitate variant interpretation and machine learning." Nucleic Acids Research 50, no. D1 (December 1, 2021): D553—D559. http://dx.doi.org/10.1093/nar/gkab1054.
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Abstract The Structural Classification of Proteins—extended (SCOPe, https://scop.berkeley.edu) knowledgebase aims to provide an accurate, detailed, and comprehensive description of the structural and evolutionary relationships amongst the majority of proteins of known structure, along with resources for analyzing the protein structures and their sequences. Structures from the PDB are divided into domains and classified using a combination of manual curation and highly precise automated methods. In the current release of SCOPe, 2.08, we have developed search and display tools for analysis of genetic variants we mapped to structures classified in SCOPe. In order to improve the utility of SCOPe to automated methods such as deep learning classifiers that rely on multiple alignment of sequences of homologous proteins, we have introduced new machine-parseable annotations that indicate aberrant structures as well as domains that are distinguished by a smaller repeat unit. We also classified structures from 74 of the largest Pfam families not previously classified in SCOPe, and we improved our algorithm to remove N- and C-terminal cloning, expression and purification sequences from SCOPe domains. SCOPe 2.08-stable classifies 106 976 PDB entries (about 60% of PDB entries).
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Núñez-Lillo, Gerardo, Lissette Ulloa-Zepeda, Catalina Pavez, Anibal Riveros, Francisca Blanco-Herrera, Reinaldo Campos-Vargas, Romina Pedreschi, and Claudio Meneses. "Unravelling the Molecular Regulation Mechanisms of Slow Ripening Trait in Prunus persica." Plants 10, no. 11 (November 5, 2021): 2380. http://dx.doi.org/10.3390/plants10112380.
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Fruit development is a complex process that involves the interplay of cell division, expansion, and differentiation. As a model to study fruit development, nectarines incapable of ripening were described as slow ripening. Slow ripening fruits remained firm and exhibited no rise in CO2 or ethylene production rates for one month or more at 20 °C. Different studies suggest that this trait is controlled by a single gene (NAC072). Transcriptome analysis between normal and slow ripening fruits showed a total of 157, 269, 976, and 5.224 differentially expressed genes in each fruit developmental stage analyzed (T1, T2, T3, and T7, respectively), and no expression of NAC072 was found in the slow ripening individuals. Using this transcriptomic information, we identified a correlation of NAC072 with auxin-related genes and two genes associated with terpene biosynthesis. On the other hand, significant differences were observed in hormonal biosynthetic pathways during fruit development between the normal and slow ripening individuals (gibberellin, ethylene, jasmonic acid and abscisic acid). These results suggest that the absence of NAC072 by the direct or indirect expression control of auxins or terpene-related genes prevents normal peach fruit development.
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Petlickaitė, Rita, Algirdas Jasinskas, Ramūnas Mieldažys, Kęstutis Romaneckas, Marius Praspaliauskas, and Jovita Balandaitė. "Investigation of Pressed Solid Biofuel Produced from Multi-Crop Biomass." Sustainability 14, no. 2 (January 11, 2022): 799. http://dx.doi.org/10.3390/su14020799.
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The paper presents the preparation and use of pressed solid biofuel of multi-crop plants (fibrous hemp (Cannabis sativa L.), maize (Zea mays L.) and faba bean (Vicia faba L.)) as mono, binary and trinomial crops. The results of the investigation show that three main chemical elements (carbon, oxygen and hydrogen) accounted for 93.1 to 94.9% of the biomass pellet content. The moisture content varied from 3.9 to 8.8%, ash content from 4.5 to 6.8% and calorific value from 16.8 to 17.1 MJ·kg−1. It was found that the density (DM) of all variants of pellets was very similar; the faba bean biomass pellets had the highest density of 1195.8 kg·m−3 DM. The initial ash deformation temperature (DT) of burning biomass pellets was detected, which varied from 976 to 1322 °C. High potassium (K), calcium (Ca) and phosphorus (P) concentrations were found in all types of biomass ash. The quantities of heavy metals in pellet ash were not large and did not exceed the permissible values according to Lithuanian legislation. These chemical properties of multi-crop biomass ash allow them to be used in agriculture for plant fertilization.
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Lajmi, Luke, Sloan Breedy, Wishrawana S. Ratnayake, and Mildred Acevedo-Duncan. "Abstract 172: Limiting medulloblastoma progression by hindering the Hedgehog signaling pathway with novel atypical protein kinase C inhibitors." Cancer Research 82, no. 12_Supplement (June 15, 2022): 172. http://dx.doi.org/10.1158/1538-7445.am2022-172.
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Abstract Medulloblastoma is the most common pediatric brain tumor, constituting 20% of all childhood brain cancers (Clin. Cancer Res. 2008, 14 (4), 971-976., Oncogenesis 2019, 8 (11), 1-11). It is a highly invasive tumor that originates in the cerebellum and has the ability to metastasize throughout the central nervous system early in its course. The median age of diagnosis is 5 years, with 80% of cases being diagnosed in the first 15 years (Asian J. Neurosurg. 2015, 10 (1), 1-4). Current treatment options include maximal safe resection, chemotherapy and craniospinal radiation (J. Neurosurg. Pediatr. 2019, 24(4), 353-363). Despite such aggressive therapeutic treatments, nearly 30% of afflicted patients succumb to this disease, and survivors cope with the long-term side effects of these treatments that have significant impacts on their quality of life (J. Neurosurg. Pediatr. 2019, 24(4), 353-363). This underscores the need for less invasive and more effective treatment methods to improve overall patient outcomes. We believe that oncogene expression resulting from the Hedgehog (Hh) signaling pathway is responsible for upregulating malignant cancer cell growth, cell survival, and migration. Preliminary dose curve studies, in which D341 and D283 medulloblastoma cell lines were treated with novel atypical protein kinase C (aPKC) inhibitors 2-acetyl-1,3-cyclopentanedione (ACPD) and 3,4-diaminonapthalene-2,7-disulfonic acid (DNDA) (Int. J. Oncol. 2017, 51(5), 1370-1382), have been shown to significantly decrease cell proliferation with increasing inhibitor concentration. Cell line D341 showed 44.2% inhibition when treated with 10 µM of ACPD and 75.2% inhibition when treated with 1 µM of DNDA while cell line D283 showed a 63.2% inhibition at 5 µM of ACPD and 73.6% inhibition at 10 µM. Future studies will be conducted to determine the inhibition mechanism of the Hh pathway in medulloblastoma by probing for different cell cycle and oncoprotein markers using Western blotting, employing the WST-1 assay to evaluate cell viability and cytotoxicity, and implementing migration and invasion assays. Citation Format: Luke Lajmi, Sloan Breedy, Wishrawana S. Ratnayake, Mildred Acevedo-Duncan. Limiting medulloblastoma progression by hindering the Hedgehog signaling pathway with novel atypical protein kinase C inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 172.
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Liu, Ziyu, Guido Toci, Angela Pirri, Barbara Patrizi, Yagang Feng, Jiabei Wei, Feng Wu, Zhaoxiang Yang, Matteo Vannini, and Jiang Li. "Fabrication, microstructures, and optical properties of Yb:Lu2O3 laser ceramics from co-precipitated nano-powders." Journal of Advanced Ceramics 9, no. 6 (November 6, 2020): 674–82. http://dx.doi.org/10.1007/s40145-020-0403-8.
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AbstractThe Yb:Lu2O3 precursor made up of spherical particles was synthesized through the co-precipitation method in the water/ethanol solvent. The 5 at% Yb:Lu2O3 powder is in the cubic phase after calcination at 1100 °C for 4 h. The powder also consists of spherical nanoparticles with the average particle and grain sizes of 96 and 49 nm, respectively. The average grain size of the pre-sintered ceramic sample is 526 nm and that of the sample by hot isostatic pressing grows to 612 nm. The 1.0 mm-thick sample has an in-line transmittance of 81.6% (theoretical value of 82.2%) at 1100 nm. The largest absorption cross-section at 976 nm is 0.96×10−20 cm2 with the emission cross-section at 1033 nm of 0.92×10−20 cm2 and the gain cross sections are calculated with the smallest population inversion parameter β of 0.059. The highest slope efficiency of 68.7% with the optical efficiency of 65.1% is obtained at 1033.3 nm in quasi-continuous wave (QCW) pumping. In the case of continuous wave (CW) pumping, the highest slope efficiency is 61.0% with the optical efficiency of 54.1%. The obtained laser performance indicates that Yb:Lu2O3 ceramics have excellent resistance to thermal load stresses, which shows great potential in high-power solid-state laser applications.
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Okuda, Keiko, Nari Harakawa, Richard A. VanEtten, Nihal Patel, Naochika Domae, Yuko Sato, and Hideyo Hirai. "Distinct Transforming and Leukemogenic Activities of Tel-Arg and Tel-Abl Oncogenes in Mice: Possible Negative Role for the Transforming Activity in C-Terminus of Arg." Blood 112, no. 11 (November 16, 2008): 2845. http://dx.doi.org/10.1182/blood.v112.11.2845.2845.
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Abstract ARG (ABL2) is a member of ABL tyrosine kinase gene family that is highly homologous to c-ABL (ABL1) in overall domain structure (SH3-SH2-SH1) and amino acid sequence. ARG has recently been implicated in the pathogenesis of human acute leukemia though t(1;12) translocations that fuse a transcription factor gene, ETV6/TEL, to ARG (Iijima et al., Blood2000;95:2126). The resulting TEL-ARG fusion tyrosine kinase is similar in structure to the TEL-ABL fusion found in some acute leukemia and atypical CML patients, and, like TEL-ABL, can transform Ba/F3 cells and fibroblasts in vitro and activate a similar set of intracellular signaling pathways (Iijima et al., Oncogene2002;21:4374). To assess the leukemogenic activity of TEL-ARG, we co-expressed TEL-ARG with GFP in mouse bone marrow using a retroviral bone marrow transduction/transplantation strategy. Whereas TEL-ABL induces rapidly fatal myelolproliferative disease (MPD) in recipient mice (Million et al., Blood2000;96:664), recipients of TEL-ARG-transduced BM did not develop overt MPD, but succumbed instead to long-latency (30–45 weeks) T-cell acute lymphoblastic leukemia/lymphoma characterized by modest leukocytosis and a malignant pleural effusion composed of Thy-1+B220- tumor cells. To study the molecular basis of the marked difference in the leukemogenic activity of TEL-ARG and TEL-ABL, we produced TEL-ARG mutants that swapped the kinase domain or C-terminus of ARG with the corresponding domain in ABL. The mutants were introduced into Ba/F3 cells by retroviral transduction and transduced cells selected for equal expression of the fusion protein by flow sorting for populations with equivalent intensity of GFP fluorescence. All chimeric proteins were expressed and showed equivalent levels of auto-phosphorylation by western blot analysis of the sorted cells. However, the quantitative transforming activity of TEL-ARG in Ba/F3 cells, measured by the number of days required to achieve measurable cell growth following IL-3 deprivation, was significantly lower than for TEL-ABL (25 ± 4.3 days for TEL-ARG vs. 1 to 2 days for TEL-ABL). A TEL-ARG mutant containing the ABL kinase domain was similar to TEL-ARG in this assay, but replacing the ARG C-terminal domain with that of ABL increased Ba/F3 transformation to levels equivalent to TEL-ABL. To further dissect the functional domains that are responsible for this effect, a new series of mutants containing internal deletions in ARG C-terminus of TEL-ARG [aa.826–976 (Delta Box1), aa.977–1213 (Delta Box2), aa 1214–1316 (Delta Box3), aa.1317–1465 (Delta Box4)] were generated. Regarding to their function, only Box2 and Box4 were reported as F- or F,G- actin binding domain. From a preliminary study using the cell lines which express each of the mutants, Delta Box 1 clones obtained an accelerated proliferation which compared with that of Tel-Abl, suggesting that there is a disadvantage for cell proliferation by ARG c-terminus. These results indicate that distinct bio-phenotype associated with Abl family tyrosine kinase is the most likely regulated by their c-terminus and the c-terminus of Arg contains functional subdomain that impairs growth signal induced by Abl family tyrosine kinase.
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Parikka, P., and M. Kokkola. "First Report of Colletotrichum acutatum on Strawberry in Finland." Plant Disease 85, no. 8 (August 2001): 923. http://dx.doi.org/10.1094/pdis.2001.85.8.923a.
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Strawberry (Fragaria × ananassa) is the most important small fruit crop in Finland. The quarantined pest Colletotrichum acutatum was detected for the first time on strawberry in August 2000, in Eastern Finland. Waiting-bed plants of cultivar Elsanta had symptoms typical of anthracnose rot (black spot) on the fruit, and small black lesions were seen on stolons. The rainy, warm, and humid weather of the summer favored the development and spread of the disease. C. acutatum was isolated from lesions on the fruit. Abundant sporulation was observed on lesions, and the fungus was readily isolated on potato dextrose agar (PDA) from surface-sterilized fruit pieces. Spores (11.5 to 19.8 × 3.3 to 4.0 μm) were acute at both ends, and acervuli with salmon pink spore masses matched the descriptions of C. acutatum (1). At first, the colonies were white and later became ash gray. The growth rate of the fungus was 8.0 to 8.8 mm per day, at 27°C. The identification was confirmed with enzyme-linked immunosorbent assay at the Central Science Laboratory, York, U.K. In order to fulfill Koch's postulates, young potted strawberry plants were inoculated by misting with a suspension of 10.4 × 106 conidia per ml of C. acutatum. Healthy runner plants of micropropagated cultivars Bounty, Cudaruska, Jonsok, Korona, and Oka (10 plants of each cultivar) were inoculated and incubated for 3 days, at 100% relative humidity. After 3 weeks at 20 to 21°C and 16 h of light per day, dark, elongated lesions measuring 2 to 15 mm were observed on the stolons. All tested cultivars developed symptoms on stolons and petioles, but no crown infections were detected. Flowering and fruit-bearing plants of cultivars Honeoye, Sara, and Senga Sengana were similarly inoculated and incubated. The first symptoms of fruit rot were detected 5 days after inoculation on the ripening fruit of Honeoye. Less severe fruit rot was seen on the fruit of Senga Sengana and the Fragaria vescana cultivar Sara. Salmon pink sporodochia developed on infected fruit, stolons, and leaves, within 5 days on moist filter paper, and C. acutatum was isolated on PDA. No other pathogens were present. Because C. acutatum is a quarantined pest in Finland, all strawberry plants of the infected lot on this particular farm were destroyed and future use of the field will be restricted. Reference: (1) C. M. Howard et al. 1992. Plant Dis. 76:976–981.
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Bowler, David, Adrian Cox, Catherine Smith, Martin Brann, Neil McGavin, Peter Clark, Linda Blanchard, et al. "Four excavations in Perth, 1979-84." Proceedings of the Society of Antiquaries of Scotland 125 (November 30, 1996): 917–99. http://dx.doi.org/10.9750/psas.125.917.999.
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Reports: medieval--post-medieval malting kilns at `Mill Street' by Martin Brann & Neil McGavin (ed David Bowler) (918--30); early medieval buildings at `King Edward Street' by Peter Clark & Linda Blanchard (ed David Bowler) (931--8); investigations into possible Dominican Friary site at `Kinnoull Street' by David Bowler & Derek Hall (939--47) including cemetery evidence; `Blackfriars House' by David Bowler & Derek Hall (947--54). The artefacts section, by B Ford (959--79) includes notes on: `Horse equipment' by B Ellis (963); `Numismatica' by N Holmes (965); `Porous ceramic material' by C Underwood (965); `Stone shot' by M Brann (966); `Doorway pediment' by N Cameron & D Bowler (966); `Ceramic building material' by D W Hall (968, 970); `Textiles' by H Bennett (971); `Leather' by C Thomas & A Walsh~(971). There are details of `The human skeletal remains from Kinnoull Street' by M Bruce (ed A Cox) (979--85), `Animal bone' by C Smith (986--9), `The botanical remains: Mill Street & King Edward Street' by D Robinson (ed C Smith) (990--3). Finally, `Pollen and particle size analysis of ditch deposits' by D Robinson (ed C Smith) (994) concludes proceedings.