Journal articles on the topic 'Bungarus candidus'

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1

Chen, Ze-Ning, Sheng-Chao Shi, Gernot Vogel, Li Ding, and Jing-Song Shi. "Multiple lines of evidence reveal a new species of Krait (Squamata, Elapidae, Bungarus) from Southwestern China and Northern Myanmar." ZooKeys 1025 (March 18, 2021): 35–71. http://dx.doi.org/10.3897/zookeys.1025.62305.

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Kraits of the genus Bungarus Daudin 1803 are widely known venomous snakes distributed from Iran to China and Indonesia. Here, we use a combination of mitochondrial DNA sequence data and morphological data to describe a new species from Yingjiang County, Yunnan Province, China: Bungarus suzhenaesp. nov. Phylogenetically, this species forms a monophyletic lineage sister to the Bungarus candidus/multicinctus/wanghaotingi complex based on cyt b and ND4 genes but forms a sister species pair with the species B. magnimaculatus Wall & Evans, 1901 based on COI gene fragments. Morphologically, B. suzhenaesp. nov. is similar to the B. candidus/multicinctus/wanghaotingi complex but differs from these taxa by a combination of dental morphology, squamation, coloration pattern, as well as hemipenial morphology. A detailed description of the cranial osteology of the new species is given based on micro-CT tomography images. We revised the morphological characters of B. candidus/multicinctus/wanghaotingi complex and verified the validity of three species in this complex. The distribution of these species was revised; the records of B. candidus in China should be attributed to B. wanghaotingi. We also provide an updated key to species of Bungarus.
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Rusmili, Muhamad Rusdi Ahmad, Tee Ting Yee, Mohd Rais Mustafa, Wayne C. Hodgson, and Iekhsan Othman. "Proteomic characterization and comparison of Malaysian Bungarus candidus and Bungarus fasciatus venoms." Journal of Proteomics 110 (October 2014): 129–44. http://dx.doi.org/10.1016/j.jprot.2014.08.001.

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3

NGUYEN, SANG NGOC, VU DANG HOANG NGUYEN, THANG QUOC NGUYEN, NGAN THANH THI LE, LUAN THANH NGUYEN, BA DINH VO, JENS V. VINDUM, ROBERT W. MURPHY, JING CHE, and YA-PING ZHANG. "A new color pattern of the Bungarus candidus complex (Squamata: Elapidae) from Vietnam based on morphological and molecular data." Zootaxa 4268, no. 4 (May 18, 2017): 563. http://dx.doi.org/10.11646/zootaxa.4268.4.7.

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Kraits with black and white bands from Nui Chua National Park, central Vietnam are morphologically similar to the Burmese Krait, Bungarus magnimaculatus, however, analysis of molecular data finds them to be nested within the B. candidus complex.
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4

Hodges, Cameron Wesley, Anji D'souza, and Sira Jintapirom. "Diurnal observation of a Malayan Krait Bungarus candidus (Reptilia: Elapidae) feeding inside a building in Thailand." Journal of Threatened Taxa 12, no. 8 (May 26, 2020): 15947–50. http://dx.doi.org/10.11609/jott.5746.12.8.15947-15950.

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Malayan Kraits Bungarus candidus have been reported to bite humans during the night after entering dwellings. We report an observation of an adult krait feeding on a colubrid snake Chrysopelea ornata during the early morning, in the hallway of a large building at the center of a university campus in Nakhon Ratchasima, Thailand. To our knowledge, this is the first observation of a wild B. candidus feeding within a building. This observation provides insight into why kraits enter human settlements, and since the event took place shortly after sunrise it also indicates that this nocturnal species can remain active during daylight when feeding. Further studies will be required to determine how often B. candidus forages among human structures.
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5

Ahmad Rusmili, Muhamad Rusdi, Iekhsan Othman, Mohd Rais Mustafa, and Wayne Hodgson. "145. In vitro Vascular Activity of Crude Bungarus candidus and Bungarus fasciatus Crude Venoms." Toxicon 60, no. 2 (August 2012): 169. http://dx.doi.org/10.1016/j.toxicon.2012.04.146.

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6

Laothong, C., and V. Sitprija. "Decreased parasympathetic activities in Malayan krait (Bungarus candidus) envenoming." Toxicon 39, no. 9 (September 2001): 1353–57. http://dx.doi.org/10.1016/s0041-0101(01)00087-3.

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7

KUCH, ULRICH, and DIETRICH MEBS. "The identity of the Javan Krait, Bungarus javanicus Kopstein, 1932 (Squamata: Elapidae): evidence from mitochondrial and nuclear DNA sequence analyses and morphology." Zootaxa 1426, no. 1 (March 15, 2007): 1–26. http://dx.doi.org/10.11646/zootaxa.1426.1.1.

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The Javan Krait (Bungarus javanicus Kopstein, 1932) was described on the basis of a single specimen that had been discovered subsequent to its delivery of lethal bites to two sleeping people in a rice field hut. Until 1936, only two additional specimens were found in the vicinity of the type locality near Cirebon on the north coast of West Java province, Indonesia. The taxonomic status of B. javanicus has remained doubtful due to its great similarity to the common and widely distributed Malayan Krait (Bungarus candidus), from which it was distinguished only by its black (vs. black-andwhite banded) colouration. We rediscovered B. javanicus near its type locality in 1993 and obtained substantial series of black kraits in West and Central Java provinces in 1996 and 1998. We provide a detailed redescription of the type specimen and the two other specimens of B. javanicus available to Kopstein. We then use nucleotide sequences of the mitochondrial cytochrome b gene to estimate relationships among 27 black and black-and-white banded kraits from Java and Bali. In addition, we use exon-primed intron-crossing primers to analyze a sequence segment of the alpha-bungarotoxin (A31) gene from ten black and black-and-white banded kraits from these islands. Four mitochondrial haplotypes were identified which exhibited minimal sequence divergence and no correlation to colouration. In particular, both external phenotypes were found in the same genealogical lineage near Indramayu, where black kraits and black-and-white banded B. candidus occur in syntopy. Neither the nucleotide sequence of intron 2 nor partial exon 2 and 3 sequences of the alphabungarotoxin (A31) gene exhibited variation within the sample from Java and Bali. Intron 2 sequence divergence between the Javan kraits and the closely related Bungarus multicinctus is 1.1%. Morphological examination of specimens of B. javanicus and B. candidus from Java revealed no differences beyond colouration. The combined evidence identifies the locally strong populations of black kraits in Java as conspecific with local B. candidus. Their regional dichromatism includes two fundamentally different patterns for predator avoidance, and is interpreted as the result of increased genetic fixation of mutations in one or several instable genes (which can cause similar pattern abnormalities in various species of Bungarus), in the course of the colonization of the alluvial plains of northern Java. These plains are of very recent origin and likely offered selective pressures different from those in older parts of the island, rendering both black and black-and-white banded phenotypes successful in predator avoidance.
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8

Yanoshita, Ryohei, Yuko Ogawa, Nobuhiro Murayama, Tamotsu Omori-Satoh, Ken-ichi Saguchi, Shigesada Higuchi, Orawan Khow, Lawan Chanhome, Yuji Samejima, and Visith Sitprija. "Molecular cloning of the major lethal toxins from two kraits (Bungarus flaviceps and Bungarus candidus)." Toxicon 47, no. 4 (March 2006): 416–24. http://dx.doi.org/10.1016/j.toxicon.2005.12.004.

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9

Grahadi, Rahmat, Fatchiyah Fatchiyah, and Nia Kurniawan. "Virtual prediction of potential immunogenic epitope of candoxin protein from Malayan krait (Bungarus candidus) venom." Journal of Pharmacy & Pharmacognosy Research 10, no. 6 (November 1, 2022): 1046–57. http://dx.doi.org/10.56499/jppres22.1469_10.6.1046.

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Context: Malayan krait (Bungarus candidus) is a snake that is considered highly venomous snake and widely distributed across Southeast Asia. Envenomation by this snake is characterized by facial weakness, paralysis, respiratory muscle weakness, and in most cases, it renders the victim dead. Unfortunately, there is only one antivenom for neutralizing venom that is only available from the Thai Red Cross Society. Aims: To predict the epitopes from candoxin protein of B. candidus venom that could be a candidate for vaccine-based antivenom. Methods: In this study, IEDB and SYFPHEITHI databases were utilized to predict candoxin epitope sequences and determine their immunogenicity, conservancy, and population coverage. Next, the epitopes were modeled, and the binding interactions between epitopes and MHC-II were analyzed. The epitope that binds into the active site of human and murine MHC-II proceeded to the next step. Then, the allergenic properties of the chosen epitope were assessed to ensure its safety. Lastly, the physicochemical characteristics prediction and molecular dynamics simulation were conducted to verify the epitope’s stability when produced in vivo. Results: The results showed that epitope 47-CFKESWREARGTRIE-61 has the best binding interaction when compared to others. This epitope was confirmed that did not show potential allergenic properties. The physicochemical properties and molecular dynamics simulation demonstrated that this epitope was stable. Conclusions: The results of this study will be useful in developing a novel antivenom for Bungarus candidus using a vaccine-based method.
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10

Chanhome, Lawan, Visith Sitprija, and Narongsak Chaiyabutr. "Effects of Bungarus candidus (Malayan krait) venom on general circulation and renal hemodynamics in experimental animals." Asian Biomedicine 4, no. 3 (June 1, 2010): 421–28. http://dx.doi.org/10.2478/abm-2010-0051.

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Abstract Background: Many studies have reported the occurrence of lethal acute renal failure after snakebites. Bungarus candidus (Malayan krait) is a medically important venomous snake distributed widely throughout Southeast Asia. The best known features of systemic envenoming by B. candidus are neurotoxic. Objective: Obtain more information on effects of B. candidus venom on changes in systemic and renal hemodynamics in experimental animals. Methods: Twelve adult male New Zealand white rabbits were used to study the effect of B. candidus venom on general circulation and renal hemodynamics. An anesthetized animal was intravenously injected with B. candidus venom at a dosage of 50μg/kg bodyweight. All changes of parameters were observed after initial post venom injection and recorded at 30 min intervals until 150 minutes after envenomation. Results: After envenomation, cardiovascular responses showed a marked decrease in mean arterial pressure within two minutes, afterwards gradually returning closely to baseline values. There were stepwise decreases in heart rate and cardiac output, while total peripheral resistance was slightly increased. The renal hemodynamics significantly decreased by glomerular filtration rate, effective renal plasma flow and effective renal blood flow, while the filtration fraction significantly increased. Envenomed animals showed a reduction in renal fraction, while renal vascular resistance stepwise increased. The plasma potassium level tended to increase. Animals showed stepwise decreases in urinary excretion of Na+, K+ and Cl-. A marked decrease in plasma calcium level was apparent at 120 minutes, while plasma creatine phosphokinase and lactate dehydrogenase levels increased at 30-120 minutes. Conclusion: A significant drop in blood pressure was attributed to a sustained fall in cardiac output, which would be associated with a reduction in heart rate. Sustained hypotension would contribute to reduction of renal blood flow, which results in decreased GFR.
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11

Dharma, Agus Pambudi, and Winarno Winarno. "ONLINE TRAINING ON THE INTRODUCTION AND HANDLING OF THE THREAT OF RATTLESNAKES DURING THE COVID-19 PANDEMIC." Indonesian Journal of Engagement, Community Services, Empowerment and Development 1, no. 1 (April 19, 2021): 31–34. http://dx.doi.org/10.53067/ijecsed.v1i1.5.

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Snakes are cold-blooded reptiles that are often found from the lowlands, headlands, soil, trees, freshwater, brackish water, to seawater, except in areas with low temperatures such as the poles. Rattlesnake bites continue to occur anytime and anywhere. Although, currently, there is a covid-19 pandemic in Indonesia. The community needs to know and identify some basic knowledge about snakes. This training was held on April 22, 2020. The method used in this training was demonstration and question and answered through the chat column on Instagram and YouTube accounts for 1 hour. The results of this online training provide additional information and knowledge to the broader community. Also, the number of participants who took part was more significant and scattered throughout Indonesia. Snakes with high venom have a pair of fangs in the upper jaw, and not all highly venomous snakes have triangular heads, such as Bungarus candidus (weling) and Bungarus fasciatus (welang).
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12

Rusmili, Muhamad Rusdi Ahmad, Iekhsan Othman, Syafiq Asnawi Zainal Abidin, Fathin Athirah Yusof, Kavi Ratanabanangkoon, Lawan Chanhome, Wayne C. Hodgson, and Janeyuth Chaisakul. "Variations in neurotoxicity and proteome profile of Malayan krait (Bungarus candidus) venoms." PLOS ONE 14, no. 12 (December 30, 2019): e0227122. http://dx.doi.org/10.1371/journal.pone.0227122.

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13

Chaisakul, Janeyuth, Muhamad Rusdi Ahmad Rusmili, Wayne C. Hodgson, Panadda Hatthachote, Kijja Suwan, Anjaree Inchan, Lawan Chanhome, Iekhsan Othman, and Krongkarn Chootip. "A Pharmacological Examination of the Cardiovascular Effects of Malayan Krait (Bungarus candidus) Venoms." Toxins 9, no. 4 (March 29, 2017): 122. http://dx.doi.org/10.3390/toxins9040122.

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14

Inoue, Tetsuya, Kunitomo Minagawa, Taketo Matsuda, Yoshihiro Yamaguchi, Atsuo Murata, and Shuji Shimazaki. "A Case of Respiratory Arrest Following a Snake Bite (Envenomation) by Bungarus candidus." Nihon Kyukyu Igakukai Zasshi 14, no. 2 (2003): 72–76. http://dx.doi.org/10.3893/jjaam.14.72.

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15

Tan, Nget-Hong, Chin-Hua Poh, and Chon-Seng Tan. "The lethal and biochemical properties of Bungarus candidus (Malayan krait) venom and venom fractions." Toxicon 27, no. 9 (January 1989): 1065–70. http://dx.doi.org/10.1016/0041-0101(89)90159-1.

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16

Rusmili, Muhamad, Tee Yee, Mohd Mustafa, Iekhsan Othman, and Wayne Hodgson. "In-vitro Neurotoxicity of Two Malaysian Krait Species (Bungarus candidus and Bungarus fasciatus) Venoms: Neutralization by Monovalent and Polyvalent Antivenoms from Thailand." Toxins 6, no. 3 (March 12, 2014): 1036–48. http://dx.doi.org/10.3390/toxins6031036.

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17

Pochanugool, Charn, Henry Wilde, Sutichai Jitapunkul, and Sakschai Limthongkul. "Spontaneous recovery from severe neurotoxic envenoming by a Malayan krait Bungarus candidus (linnaeus) in Thailand." Wilderness & Environmental Medicine 8, no. 4 (November 1997): 223–25. http://dx.doi.org/10.1580/1080-6032(1997)008[0223:srfsne]2.3.co;2.

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18

V., Rani Parvathy, Kandala V. R. Chary, R. Manjunatha Kini, and Girjesh Govil. "Solution structure of candoxin, a novel three-finger toxin from the venom of Bungarus candidus." Arkivoc 2006, no. 15 (September 8, 2006): 1–16. http://dx.doi.org/10.3998/ark.5550190.0007.f01.

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19

TORRES, Allan M., R. Manjunatha KINI, Nirthanan SELVANAYAGAM, and Philip W. KUCHEL. "NMR structure of bucandin, a neurotoxin from the venom of the Malayan krait (Bungarus candidus)." Biochemical Journal 360, no. 3 (December 15, 2001): 539. http://dx.doi.org/10.1042/0264-6021:3600539.

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TORRES, Allan M., R. Manjunatha KINI, Nirthanan SELVANAYAGAM, and Philip W. KUCHEL. "NMR structure of bucandin, a neurotoxin from the venom of the Malayan krait (Bungarus candidus)." Biochemical Journal 360, no. 3 (December 10, 2001): 539–48. http://dx.doi.org/10.1042/bj3600539.

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A high-resolution solution structure of bucandin, a neurotoxin from Malayan krait (Bungarus candidus), was determined by 1H-NMR spectroscopy and molecular dynamics. The average backbone root-mean-square deviation for the 20 calculated structures and the mean structure is 0.47 Å (1 Å = 0.1nm) for all residues and 0.24 Å for the well-defined region that spans residues 23–58. Secondary-structural elements include two antiparallel β-sheets characterized by two and four strands. According to recent X-ray analysis, bucandin adopts a typical three-finger loop motif and yet it has some peculiar characteristics that set it apart from other common α-neurotoxins. The presence of a fourth strand in the second antiparallel β-sheet had not been observed before in three-finger toxins, and this feature was well represented in the NMR structure. Although the overall fold of the NMR structure is similar to that of the X-ray crystal structure, there are significant differences between the two structures that have implications for the pharmacological action of the toxin. These include the extent of the β-sheets, the conformation of the region spanning residues 42–49 and the orientation of some side chains. In comparison with the X-ray structure, the NMR structure shows that the hydrophobic side chains of Trp27 and Trp36 are stacked together and are orientated towards the tip of the middle loop. The NMR study also showed that the two-stranded β-sheet incorporated in the first loop, as defined by residues 1–22, and the C-terminus from Asn59, is probably flexible relative to the rest of the molecule. On the basis of the dispositions of the hydrophobic and hydrophilic side chains, the structure of bucandin is clearly different from those of cytotoxins.
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Tsai, Inn-Ho, Hwa-Yao Hsu, and Ying-Ming Wang. "A novel phospholipase A2 from the venom glands of Bungarus candidus: cloning and sequence-comparison." Toxicon 40, no. 9 (September 2002): 1363–67. http://dx.doi.org/10.1016/s0041-0101(02)00150-2.

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22

Nirthanan, S., E. Charpantier, P. Gopalakrishnakone, M. C. E. Gwee, H. E. Khoo, L. S. Cheah, R. M. Kini, and D. Bertrand. "Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus )." British Journal of Pharmacology 139, no. 4 (June 2003): 832–44. http://dx.doi.org/10.1038/sj.bjp.0705299.

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23

Murakami, M., R. Kini, and R. Arni. "Crystal Structure of Bucain, a Three-Fingered Toxin from the Venom of the Malayan Krait (Bungarus candidus)." Protein & Peptide Letters 16, no. 12 (December 1, 2009): 1473–77. http://dx.doi.org/10.2174/092986609789839304.

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24

Utkin, Yuri N., Ulrich Kuch, Igor E. Kasheverov, Dmitry S. Lebedev, Ella Cederlund, Brian E. Molles, Iakov Polyak, et al. "Novel long-chain neurotoxins from Bungarus candidus distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors." Biochemical Journal 476, no. 8 (April 26, 2019): 1285–302. http://dx.doi.org/10.1042/bcj20180909.

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Abstract αδ-Bungarotoxins, a novel group of long-chain α-neurotoxins, manifest different affinity to two agonist/competitive antagonist binding sites of muscle-type nicotinic acetylcholine receptors (nAChRs), being more active at the interface of α–δ subunits. Three isoforms (αδ-BgTx-1–3) were identified in Malayan Krait (Bungarus candidus) from Thailand by genomic DNA analysis; two of them (αδ-BgTx-1 and 2) were isolated from its venom. The toxins comprise 73 amino acid residues and 5 disulfide bridges, being homologous to α-bungarotoxin (α-BgTx), a classical blocker of muscle-type and neuronal α7, α8, and α9α10 nAChRs. The toxicity of αδ-BgTx-1 (LD50 = 0.17–0.28 µg/g mouse, i.p. injection) is essentially as high as that of α-BgTx. In the chick biventer cervicis nerve–muscle preparation, αδ-BgTx-1 completely abolished acetylcholine response, but in contrast with the block by α-BgTx, acetylcholine response was fully reversible by washing. αδ-BgTxs, similar to α-BgTx, bind with high affinity to α7 and muscle-type nAChRs. However, the major difference of αδ-BgTxs from α-BgTx and other naturally occurring α-neurotoxins is that αδ-BgTxs discriminate the two binding sites in the Torpedo californica and mouse muscle nAChRs showing up to two orders of magnitude higher affinity for the α–δ site as compared with α–ε or α–γ binding site interfaces. Molecular modeling and analysis of the literature provided possible explanations for these differences in binding mode; one of the probable reasons being the lower content of positively charged residues in αδ-BgTxs. Thus, αδ-BgTxs are new tools for studies on nAChRs.
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Fatmawati, Nimas Ayu, Bainah Sari Dewi, Rusita Rusita, Yulia Rahma Fitriana, and Indra Gumay Febryano. "Keanekaragaman Jenis Reptil Di Laboratorium Lapang Terpadu Universitas Lampung." Jurnal Rimba Lestari 1, no. 2 (October 31, 2022): 114–23. http://dx.doi.org/10.29303/rimbalestari.v1i2.402.

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Reptil adalah hewan berdarah dingin yang perlu diketahui keanekaragaman dan kemerataannya sebagai bio-indikator lingkungan. Tujuan penelitian adalah untuk mengetahui keanekaragaman dan kemerataan jenis reptil. Penelitian dilakukan pada bulan Desember 2020-Januari 2021 di Laboratorium Lapang Terpadu Universitas Lampung. Pengumpulan data penelitian menggunakan Metode Visual Encounter Survey (VES) dengan kombinasi metode Time Search lalu hasilnya dianalisis secara kuantitatif dengan menggunakan indeks keanekaragaman Shannon-Wiener dan indeks kemeretaan jenis. Hasil penelitian menunjukkan terdapat lima jenis reptil yang teramati yaitu cecak dinding (Hemidactylus frenatus), kadal kebun (Eutropis multifasciata), ular kadut belang (Hemalopsis buccata), Kadal rumput (Takydromus sexlineatus) dan ular welang (Bungarus candidus) dengan kategori keanekaragaman sedang. Hal ini karena habitat masih memiliki ketersediaan pakan yang cukup, sedangkan akibat adanya aktivitas manusia habitat sedikit mengalami gangguan. Pada ketiga habitat persebaran reptil termasuk merata dan kemerataan jenis reptil masuk ke dalam kategori komunitas stabil. Spesies reptil yang ditemukan tidak jauh berbeda karena jarak pada ketiga habitat tidak terlalu jauh yang memudahkan spesies berpindah tempat. Keseimbangan lingkungan kampus dapat diketahui dengan melakukan monitoring dan penelitian lanjutan tentang keberadaan reptil di Universitas Lampung. Selain itu, upaya lain untuk mengurangi perburuan serta perdagangan ilegal reptil yaitu dengan memberikan status lindung terhadap spesies reptil.
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Pachiappan, A., M. M. Thwin, J. Manikandan, and P. Gopalakrishnakone. "Glial inflammation and neurodegeneration induced by candoxin, a novel neurotoxin from Bungarus candidus venom: global gene expression analysis using microarray." Toxicon 46, no. 8 (December 2005): 883–99. http://dx.doi.org/10.1016/j.toxicon.2005.08.017.

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Khow, O. "Isolation, Toxicity and Amino Terminal Sequences of Three Major Neurotoxins in the Venom of Malayan Krait (Bungarus candidus) from Thailand." Journal of Biochemistry 134, no. 6 (December 1, 2003): 799–804. http://dx.doi.org/10.1093/jb/mvg187.

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28

Jiang, Yx, Y. Ma, and Y. Cheng. "Transcriptome and Coexpression Network Analysis of the Human Glioma Cell Line Hs683 Exposed to Candoxin." Journal of International Medical Research 40, no. 3 (June 2012): 887–98. http://dx.doi.org/10.1177/147323001204000307.

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OBJECTIVE: Gliomas are the most common primary tumours of the central nervous system. Snake venom, such as candoxin (CDX) isolated from Bungarus candidus, inhibits glioma cell proliferation. This study explored the gene regulation profile of CDX-treated human glioma Hs683 cells. METHODS: Using microarray technology and bioinformatics analyses the underlying molecular mechanism of action of CDX was evaluated by constructing gene regulation and protein—protein interaction coexpression networks. RESULTS: CDX treatment induced a large number of related genes at the transcriptional level. The MYC gene (v-myc myelocytomatosis viral oncogene homologue [avian]) had a key role in the response of Hs683 cells to CDX treatment. Activation of MYC upregulated NDRG1 (N-myc downstream regulated 1), WNT10B (wingless-type mouse mammary tumour virus integration site family, member 10B), CASP9 (caspase 9, apoptosis-related cysteine peptidase) and CDKN2A (cyclin-dependent kinase inhibitor 2A), and downregulated ID3 (inhibitor of DNA binding 3, dominant negative helix—loop—helix protein) and SLC1A4 (solute carrier family 1 [glutamate/neutral amino acid transporter], member 4). In addition, a subnetwork was constructed among SPP1 (secreted phosphoprotein 1), SDC1 (syndecan 1) and CD44 based on protein—protein interactions, and these genes were predicted to be involved in glioma cell invasion. CONCLUSION: These findings might provide novel therapeutic targets for glioma chemotherapy.
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Karsani, Saiful Anuar, and Iekhsan Othman. "Isolation, complete amino acid sequence and characterization of a previously unreported post-synaptic neurotoxin – AlphaN3, from the venom of Bungarus candidus." Biochemical and Biophysical Research Communications 389, no. 2 (November 2009): 343–48. http://dx.doi.org/10.1016/j.bbrc.2009.08.145.

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Trinh, Kiem Xuan, Quyen Le Khac, Long Xuan Trinh, and David A. Warrell. "Hyponatraemia, rhabdomyolysis, alterations in blood pressure and persistent mydriasis in patients envenomed by Malayan kraits (Bungarus candidus) in southern Viet Nam." Toxicon 56, no. 6 (November 2010): 1070–75. http://dx.doi.org/10.1016/j.toxicon.2010.06.026.

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Kuch, Ulrich, Brian E. Molles, Tamotsu Omori-Satoh, Lawan Chanhome, Yuji Samejima, and Dietrich Mebs. "Identification of alpha-bungarotoxin (A31) as the major postsynaptic neurotoxin, and complete nucleotide identity of a genomic DNA of Bungarus candidus from Java with exons of the Bungarus multicinctus alpha-bungarotoxin (A31) gene." Toxicon 42, no. 4 (September 2003): 381–90. http://dx.doi.org/10.1016/s0041-0101(03)00168-5.

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Trinh, Kiem Xuan, and Long Xuan Trinh. "The Production Of bungarus Candidus Antivenom From Horses Immunized With Venom & it??s Application For The Treatment Of Snake Bite Patients In Vietnam." Therapeutic Drug Monitoring 27, no. 2 (April 2005): 230. http://dx.doi.org/10.1097/00007691-200504000-00091.

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33

Kini, R. Manjunatha. "Toxins for decoding interface selectivity in nicotinic acetylcholine receptors." Biochemical Journal 476, no. 10 (May 28, 2019): 1515–20. http://dx.doi.org/10.1042/bcj20190255.

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Abstract Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that play crucial roles in neurotransmission and regulate complex processes in brain functions, including anxiety, learning and memory, food intake, drug addiction, cognition and nociception. To perform these and other functions, a diverse array of nAChR subtypes are generated by homomeric or heteromeric assembly of 17 homologous nAChR subunits. Agonists, acetylcholine and nicotine, bind to the interface formed between two α subunits and between α and non-α subunits to activate the nAChR and allow cation influx. The diversity of subunit interfaces determines the channel properties, the responses to different agonists/antagonists, desensitization and downstream signaling and thus, define specialized properties and functions. Over the last several decades, snake venom neurotoxins have contributed to the purification, localization and characterization of molecular details of various nAChRs. Utkin et al. have described the purification and characterization of αδ-bungarotoxins, a novel class of neurotoxins in a recent paper published in the Biochemical Journal [Biochem. J. (2019) 476, 1285–1302]. These toxins from Bungarus candidus venom preferably bind to α–δ site with two orders of magnitude higher affinity compared with α–γ or α–ε sites. The subtle changes in the structure of αδ-bungarotoxins led to variation in interface selectivity. Such new classes of antagonists will offer us great opportunity to delineate the pharmacophores and design new highly selective antagonists. Thus, their findings provide new impetus to re-evaluate molecular details of pharmacological properties of α-neurotoxins with careful consideration towards subtype-, interface- and species-selectivity.
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34

Dinh, Quang Kien, and Duc Ngoc Ngo. "MECHANICAL VENTILATION IN PATIENTS BITTEN BY BUNGARUS CANDIDUS." Journal of Medicine and Pharmacy, April 2017, 79–84. http://dx.doi.org/10.34071/jmp.2017.2.14.

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Background: Bungarus candidus is a common accident, leading to respiratory failure due to respiratory muscle paralysis. Artificial ventilation is an essential intervention to cure. Objective: Assess results of artificial ventilation in patients bitten by Bungarus candidus. Subjects and Methods: The ventilation method is volume control with 2 different Vt levels: Vt 8-10ml/kg with PEEP 5cmH2O versus Vt 12-15ml/kg with out PEEP. To describe figures of ventilation, complication and microbiology causes of pneumonia. Results: 64 patients were put on ventilation. Average time of artificial ventilation was 9.8±7.1 days. Complications were due to ventilator-associated pneumonia (59.4%), the most common is Acinetobater baumanii 45%, followed by P. aeruginosa, K. pneumoniae, S. and Candida albicans. Complete recovery is 94%, sequelae is 3% and mortality is 3%. Sequelae and mortality mainly is due to respiratory failure and complications associated with mechanical ventilation. Conclusion: High Vt 12-15ml/kg mode is less atalectasis than Vt 8-10ml/kg with PEEP 5cmH2O. Complications mainly related to ventilator-associated pneumonia, the most common etiology is A.baumanii. Key words: Bungarus candidus, mechanical ventilation, respiratory muscle paralysis, complications.
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Thongproh, Prapaiporn, JIDAPA CHUNSKUL, PEERASIT RONGCHAPHO, CHANTIP CHUAYNKERN, YODCHAIY CHUAYNKERN, RUTTAPON SRISONCHAI, CHIRAWUTH SAENGSRI, et al. "Prey items of some amphibians and reptiles in Phu Khieo–Nam Nao Forest Complex, northeastern Thailand." Biodiversitas Journal of Biological Diversity 21, no. 9 (August 16, 2020). http://dx.doi.org/10.13057/biodiv/d210925.

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Abstract. Thongproh P, Chunskul J, Rongchapho P, Chuaynkern C, Chuaynkern Y, Srisonchai R, Saengsri C, Aonpime P, Phochayavanich R, Kanishthajata P, Phusaensri S, Prompalad S, Tongpun S, Arkajag J, Duengkae P. 2020. Prey items of some amphibians and reptiles in Phu Khieo–Nam Nao Forest Complex, Northeastern Thailand. Biodiversitas 21: 4124-4130. We reported prey items for two amphibians (Fejervarya limnocharis and Sylvirana nigrovittata) and three reptiles (Hebius sp., Bungarus candidus and Xenopeltis unicolor) from several areas of Phu Khieo–Nam Nao Forest Complex (northeastern Thailand) based on direct observation method. Fejervarya limnocharis (Anura: Dicroglossidae) consumed Amynthas sp. (Clitellata: Megascolecidae) in Nam Nao National Park (Phetchabun Province), while Sylvirana nigrovittata (Anura: Ranidae) consumed Megaustenia sp. (Gastropoda: Ariophantidae) in Phu Long Forest (Chaiyaphum Province). Consumption of snails in Sylvirana nigrovittata was documented as the first report on this prey item for the species. In Phu Luang Wildlife Sanctuary (Loei Province), Hebius sp. (Serpentes: Colubridae) consumed Fejervarya limnocharis while Bungarus candidus (Serpentes: Elapidae) consumed Argyrophis muelleri (Serpentes: Typhlopidae). Xenopeltis unicolor (Serpentes: Xenopeltidae) consumed Glyphoglossus molossus (Anura: Microhylidae) in Phu Wiang National Park (Khon Kaen Province).
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Charoenpitakchai, Mongkon, Kulachet Wiwatwarayos, Nattapon Jaisupa, Muhamad Rusdi Ahmad Rusmili, Supachoke Mangmool, Wayne C. Hodgson, Chetana Ruangpratheep, Lawan Chanhome, and Janeyuth Chaisakul. "Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand." Journal of Venomous Animals and Toxins including Tropical Diseases 24, no. 1 (March 9, 2018). http://dx.doi.org/10.1186/s40409-018-0146-y.

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Hodges, Cameron Wesley, Benjamin Michael Marshall, Jacques George Hill, and Colin Thomas Strine. "Malayan kraits (Bungarus candidus) show affinity to anthropogenic structures in a human dominated landscape." Scientific Reports 12, no. 1 (May 3, 2022). http://dx.doi.org/10.1038/s41598-022-11255-z.

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AbstractAnimal movement can impact human–wildlife conflict by influencing encounter and detection rates. We assess the movement and space use of the highly venomous and medically important Malayan krait (Bungarus candidus) on a suburban university campus. We radio-tracked 14 kraits for an average of 114 days (min: 19, max: 218), during which we located individuals an average of 106 times (min: 21, max: 229) each. Most individuals displayed some level of attraction to buildings (n = 10) and natural areas (n = 12); we identified a similar unambiguous pattern of attraction to buildings and natural areas at the population level (of our sample). Snakes remained in shelter sites for long durations (max: 94 days) and revisited sites on average every 15.45 days. Over 50% of locations were within human settlements and 37.1% were associated with buildings. We found generally seasonal patterns of activity, with higher activity in wet seasons, and lower activity in the hot season. These results show frequent proximity between Malayan kraits and humans at the university; thereby, suggesting a near constant potential for human-wildlife conflict. Despite the fact that no snakebites from this species occurred at the university during our study period, substantial education and awareness training should be considered to ensure continued coexistence on campus.
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Hodges, Cameron Wesley, Curt Hrad Barnes, Porramin Patungtaro, and Colin Thomas Strine. "Deadly dormmate: A case study on Bungarus candidus living among a student dormitory with implications for human safety." Ecological Solutions and Evidence 2, no. 1 (January 2021). http://dx.doi.org/10.1002/2688-8319.12047.

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Ratanabanangkoon, Kavi, Pavinee Simsiriwong, Kritsada Pruksaphon, Kae Yi Tan, Bunkuea Chantrathonkul, Sukanya Eursakun, and Choo Hock Tan. "An in vitro potency assay using nicotinic acetylcholine receptor binding works well with antivenoms against Bungarus candidus and Naja naja." Scientific Reports 8, no. 1 (June 26, 2018). http://dx.doi.org/10.1038/s41598-018-27794-3.

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