Academic literature on the topic 'Broadly neutralizing antibodies (bNAbs)'
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Journal articles on the topic "Broadly neutralizing antibodies (bNAbs)"
Karuna, Shelly T., and Lawrence Corey. "Broadly Neutralizing Antibodies for HIV Prevention." Annual Review of Medicine 71, no. 1 (January 27, 2020): 329–46. http://dx.doi.org/10.1146/annurev-med-110118-045506.
Full textYang, Guang, Mengfei Liu, Kevin Wiehe, Nathan Nicely, Barton Haynes, John Mascola, Pamela Bjorkman, and Garnett Kelsoe. "HIV broadly neutralizing antibodies and immunological tolerance (VAC7P.988)." Journal of Immunology 192, no. 1_Supplement (May 1, 2014): 141.33. http://dx.doi.org/10.4049/jimmunol.192.supp.141.33.
Full textLubow, Jay, Lisa M. Levoir, Duncan K. Ralph, Laura Belmont, Maya Contreras, Catiana H. Cartwright-Acar, Caroline Kikawa, et al. "Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses." PLOS Pathogens 19, no. 10 (October 9, 2023): e1011722. http://dx.doi.org/10.1371/journal.ppat.1011722.
Full textSprenger, Kayla G., Joy E. Louveau, Pranav M. Murugan, and Arup K. Chakraborty. "Optimizing immunization protocols to elicit broadly neutralizing antibodies." Proceedings of the National Academy of Sciences 117, no. 33 (August 3, 2020): 20077–87. http://dx.doi.org/10.1073/pnas.1919329117.
Full textGlazkova, D. V., E. V. Bogoslovskaya, G. A. Shipulin, and S. M. Yudin. "Broadly neutralizing antibodies for the treatment of HIV infection." HIV Infection and Immunosuppressive Disorders 13, no. 3 (October 24, 2021): 81–95. http://dx.doi.org/10.22328/2077-9828-2021-13-3-81-95.
Full textShrader, Hannah, Sabrina Helmold Hait, Sarah Lovelace, Meaghan Kilner, Chen-Hsiang Shen, Emily Coates, Martin Gaudinski, et al. "Phenotypic analysis of HIV-1 resistance to CD4 binding site broadly-neutralizing antibodies." Journal of Immunology 210, no. 1_Supplement (May 1, 2023): 223.08. http://dx.doi.org/10.4049/jimmunol.210.supp.223.08.
Full textSteichen, Jon M., Ying-Cing Lin, Colin Havenar-Daughton, Simone Pecetta, Gabriel Ozorowski, Jordan R. Willis, Laura Toy, et al. "A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses." Science 366, no. 6470 (October 31, 2019): eaax4380. http://dx.doi.org/10.1126/science.aax4380.
Full textThavarajah, Jannifer Jasmin, Bo Langhoff Hønge, and Christian Morberg Wejse. "The Use of Broadly Neutralizing Antibodies (bNAbs) in HIV-1 Treatment and Prevention." Viruses 16, no. 6 (June 4, 2024): 911. http://dx.doi.org/10.3390/v16060911.
Full textKumar, Rajesh, Huma Qureshi, Suprit Deshpande, and Jayanta Bhattacharya. "Broadly neutralizing antibodies in HIV-1 treatment and prevention." Therapeutic Advances in Vaccines and Immunotherapy 6, no. 4 (August 2018): 61–68. http://dx.doi.org/10.1177/2515135518800689.
Full textXu, Ling, Amarendra Pegu, Ercole Rao, Nicole Doria-Rose, Jochen Beninga, Krisha McKee, Dana M. Lord, et al. "Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques." Science 358, no. 6359 (September 20, 2017): 85–90. http://dx.doi.org/10.1126/science.aan8630.
Full textDissertations / Theses on the topic "Broadly neutralizing antibodies (bNAbs)"
Nemoz, Benjamin. "Exploration longitudinale à haut débit et en cellule unique du répertoire d'anticorps neutralisants à large spectre chez un neutraliseur d'élite du VIH-1." Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALV012.
Full textHuman Immunodeficiency Virus type 1 (HIV-1) infection remains a major global health concern, with an estimated 37.7 million people living with the virus worldwide and new contaminations above a million cases yearly. Efficient anti-retroviral therapies are available, allowing a sustained relief for infected individuals. These therapeutics have also contributed to a better prevention and helped curb the epidemic, notably in high-income countries. However, a vaccine is still highly awaited for controlling this epidemic, especially in lower-income regions and precarious settings.The protective role of neutralizing antibodies (NAbs) has been unequivocally demonstrated in both animal models of HIV infection and in human settings. Consequently, the development of a B-cell-based vaccine capable of eliciting antibodies (Abs) with the ability to neutralize the majority of circulating viruses, namely broadly NAbs (bNAbs), could be foreseen as an answer to the HIV pandemic.The investigation of bNAb development in HIV-1 elite neutralizers provides valuable insights to inform the design of such vaccines. To date, most of the undertaken studies have relied on conventional single B-cell FACS sorting to isolate bNAbs. In the present study, we have used the Chromium Single Cell Immune Profiling approach to conduct a high-throughput longitudinal single-cell exploration of the B-cell repertoire in an HIV-1 elite neutralizer. Importantly, this novel method enables the use of a much greater number of HIV envelope glycoprotein (Env) baits compared to regular FACS-based Ab isolation studies, providing a more comprehensive view of the anti-Env Ab repertoire. In addition, this approach yields a wealth of information on the nature of the specific Abs identified and the corresponding B-cells.The study enabled the uncovering of the sequence of 12,130 putative HIV Env specific Abs. Antibodies from 39 lineages were produced and tested for neutralization, revealing 21 distinct neutralizing lineages. The results thus demonstrated the ability of the method to explore large antigen-specific Ab repertoires from longitudinal samples. The neutralizing activity of Abs from four neutralizing lineages together recapitulated the serum activity of the donor, achieving neutralization against 62.4 % of a large predictive panel of 126 pseudoviruses. One of these neutralizing Ab lineages was shown to target the gp120 high-mannose patch supersite with great breadth and potency; Abs from this lineage were sensitive to the presence of a glycan in position N332. A single of those Abs achieved most of the neutralization breadth (51.1 %) with a high potency (mean IC50 of 91.1 ng.mL-1). This Ab exhibited a 23 AA-long CDRH3 and 20 % somatic hypermutation (SMH). The lineage showed continuous evolution over 6.5 years of maturation, with observed SHM rates ranging from 2.0 % to 30.6 % for the heavy chain, without any insertions or deletions.Conventional FACS-based sorting was previously used to isolate bNAbs from the same donor. In comparison, the single cell high-throughput approach made possible the isolation of orders of magnitude more Abs. Furthermore, the newly isolated NAbs were overall more potent and broader than those isolated previously, indicating the superiority of the novel method in recovering neutralizing lineages. Ongoing structural studies will elucidate the epitopes responsible for the broad neutralization observed in this donor. Together, the findings may help the design of reverse vaccine approaches, which show promise in the development of an effective AIDS vaccine
Derby, Nina Rafterman. "Designing immunogens to elicit broadly reactive neutralizing antibodies to the HIV envelope /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9302.
Full textPenn-Nicholson, Adam Garth. "Characterization and evaluation of approaches to elicit Broadly Reactive Neutralizing Antibodies against HIV-1." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1205433621.
Full textSuphaphiphat, Karunasinee. "Anti-viral immune response in the semen of cynomolgus macaques and inhibition of cell to cell transmission by broadly neutralizing antibodies in an SIV/SHIV model of infection SHIV162P3 transmission by semen 1 leukocytes is efficiently 2 inhibited by broadly neutralizing antibodies." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS599.
Full textHIV-1 sexual transmission occurs mostly through contaminated semen, which contains both free virions and infected leukocytes. Moreover, factors in seminal plasma (SP) can influence both semen infectivity and host’s response. Therefore, we used the experimental model of Simian Immunodeficiency Virus (SIV) infection of macaques, to investigate semen cells infectivity and the antiviral immune responses and to evaluate the potency of broadly neutralizing antibodies (bNAbs) to block cell-to-cell virus transmission.In SIVmac251 infected cynomolgus macaques, we investigated SIV-specific innate and adaptive responses in semen, including CD8+ T cell response, humoral response and levels of cytokines, chemokines and growth factors. SIV infection induced pro-inflammatory and immunoregulatory cytokines in semen and a concomitant upregulation of activated CD69+ CD8+ T cells and CCR5+ CXCR3+ CD8+ T cells. Neither SIV-specific CD8+ T-cell responses nor humoral responses controlled seminal viral shedding. Failure to control viral replication in SIV-infected semen is related to a general inflammation and immune activation, which possibly mirrors what happen in the male genital tract and which could lead to enhanced HIV/SIV transmission.Moreover, we developed cell-to-cell transmission assays, using either TZM-bl or human PBMC as target cells and SHIV162P3-infected splenocytes and CD45+ semen leukocytes as donor cells, and evaluated bNAbs-mediated inhibition. The bNAb panel included four 1st generation bNAbs and eight 2nd generation bNAbs. A combination of 1st generation bNAbs (2F5+2G12+4E10) was able to efficiently inhibit CAV transmission, while double combination or single bNAbs showed reduced potency. Of note, individual 2nd generation bNAbs inhibited transmission as efficiently as bNAbs combinations. An anti-V3 bNAb has been selected to evaluate its potential to block cell-to-cell transmission in vivo
Corti, Davide. "Analysis of the human B cell memory repertoire against infectious pathogens and isolation of broadly neutralizing human monoclonal antibodies /." Bern : [s.n.], 2008. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Full textYuan, Tingting, and 袁婷婷. "Identification of intermediate antibodies of broadly neutralizing HIV-1 human monoclonal antibody b12 and characterization of variable loops of HIV-1 envelop glycoprotein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196445.
Full textGardner, Matthew Ryan. "Targeting the CD4- and Coreceptor-Binding Sites of the HIV-1 Envelope Glycoprotein." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11644.
Full textCheng, Yuxing. "Elicitation of antibody responses against the HIV-1 gp41 Membrane Proximal External Region (MPER)." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11427.
Full textMiles, Brodie, Shannon M. Miller, and Elizabeth Connick. "CD4 T Follicular Helper and Regulatory Cell Dynamics and Function in HIV Infection." FRONTIERS MEDIA SA, 2016. http://hdl.handle.net/10150/622733.
Full textHashem, Anwar. "Targeting the Highly Conserved Sequences in Influenza A Virus." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24058.
Full textBooks on the topic "Broadly neutralizing antibodies (bNAbs)"
Cox, Josephine H., Stuart Z. Shapiro, Liza Dawson, Cynthia Geppert, Andrew M. Siegel, and M. Patricia D’Souza. Vaccines for The Prevention and Treatment of HIV Infection. Edited by Mary Ann Cohen, Jack M. Gorman, Jeffrey M. Jacobson, Paul Volberding, and Scott Letendre. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199392742.003.0032.
Full textSchommers, Philipp, Harry Gristick, Marit J. Van Gils, and Kshitij Wagh, eds. Novel Concepts in Using Broadly Neutralizing Antibodies for HIV-1 Treatment and Prevention. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-305-6.
Full textBook chapters on the topic "Broadly neutralizing antibodies (bNAbs)"
Wu, Xueling. "HIV Broadly Neutralizing Antibodies: VRC01 and Beyond." In HIV Vaccines and Cure, 53–72. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0484-2_3.
Full textZhou, Tongqing, and Kai Xu. "Structural Features of Broadly Neutralizing Antibodies and Rational Design of Vaccine." In HIV Vaccines and Cure, 73–95. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0484-2_4.
Full textPauthner, Matthias G., and Lars Hangartner. "Broadly Neutralizing Antibodies to Highly Antigenically Variable Viruses as Templates for Vaccine Design." In Current Topics in Microbiology and Immunology, 31–87. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/82_2020_221.
Full textZhang, Mei-Yun, and Dimiter S. Dimitrov. "Sequential Antigen Panning for Selection of Broadly Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies." In Methods in Molecular Biology, 143–54. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-302-2_11.
Full textVan Regenmortel, Marc H. V. "Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 Not Inform the Rational Design of an HIV-1 Vaccine?" In HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design, 221–28. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-32459-9_19.
Full textMorris, L., and T. A. Moody. "Broadly Neutralizing Antibodies." In Human Vaccines, 3–21. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-802302-0.00012-1.
Full textMohamed, Yehia. "The Future of HIV Vaccine Development, Learned Lessons from COVID-19 Pandemic." In New Topics in Vaccine Development [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.114355.
Full textNi, Fengyun, and Qinghua Wang. "Stem-specific Broadly Neutralizing Antibodies of Influenza Virus Hemagglutinin." In Influenza: Current Research, 1–16. Caister Academic Press, 2016. http://dx.doi.org/10.21775/9781910190432.01.
Full textHaynes, Barton F., Kevin O. Saunders, Garnett Kelsoe, John R. Mascola, and Gary J. Nabel. "The Cellular and Molecular Biology of HIV-1 Broadly Neutralizing Antibodies." In Molecular Biology of B Cells, 441–61. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-397933-9.00024-2.
Full textMallard, Bonnie, Mehdi Emam, Shannon Cartwright, Tess Altvater-Hughes, Alexandra Livernois, Lauri Wagter-Lesperance, Douglas C. Hodgins, et al. "Advances in understanding immune response in dairy cattle." In Improving dairy herd health Improving, 121–62. Burleigh Dodds Science Publishing, 2021. http://dx.doi.org/10.19103/as.2020.0086.06.
Full textConference papers on the topic "Broadly neutralizing antibodies (bNAbs)"
Morton, Scott P., and Joshua L. Phillips. "pH Dependent Binding Energies of Broadly Neutralizing Antibodies." In 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2021. http://dx.doi.org/10.1109/bibm52615.2021.9669511.
Full textSolodkov, P. P., T. N. Belovezhets, A. N. Chikaev, K. O. Baranov, S. V. Kulemzin, A. A. Gorchakov, S. V. Guselnikov, et al. "SINGLE DOMAIN LLAMA ANTIBODIES BROADLY NEUTRALIZING SARS-COV-2 VARIANTS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-127.
Full textFlyak, Andrew I., Stormy Ruiz, Michelle Colbert, Tiffany Luong, James E. Crowe, Justin R. Bailey, and Pamela J. Bjorkman. "Abstract B109: Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design." In Abstracts: Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 30 - October 3, 2018; New York, NY. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr18-b109.
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