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Journal articles on the topic "Brm"

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HORIKOSHI, Takashi. "BRM therapy." Skin Cancer 8, no. 1 (1993): 43–50. http://dx.doi.org/10.5227/skincancer.8.43.

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Thompson, Kenneth W., Stefanie B. Marquez, Li Lu, and David Reisman. "Induction of functional Brm protein from Brm knockout mice." Oncoscience 2, no. 4 (April 18, 2015): 349–61. http://dx.doi.org/10.18632/oncoscience.153.

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Kataoka, Kazunori. "Biological Response Modifier (BRM)." Kobunshi 41, no. 10 (1992): 722a. http://dx.doi.org/10.1295/kobunshi.41.722a.

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Liu, Zhao-Yang, Ze-guang Wang, Wei Zhang, Hai-mei Tian, Hui Li, Di-ya Na, Dong-yan Cao, Yi Liu, and Mo Li. "Antitumor effect of BRM." Chinese Journal of Cancer Research 14, no. 3 (September 2002): 195–201. http://dx.doi.org/10.1007/s11670-002-0044-1.

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Fischer, Marcus, Florian Imgrund, Christian Janiesch, and Axel Winkelmann. "Directions for future research on the integration of SOA, BPM, and BRM." Business Process Management Journal 25, no. 7 (October 14, 2019): 1491–519. http://dx.doi.org/10.1108/bpmj-05-2018-0130.

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Purpose Digital transformation has been changing the economic environment of enterprises in recent years. To remain competitive, they rely on an extensible software architecture, flexible workflow execution, and automated decision management. The concepts of service-oriented architectures (SOA), business process management (BPM), and business rules management (BRM) provide an adequate, yet isolated means of addressing many of these requirements. The paper aims to discuss these issues. Design/methodology/approach This study adapts from established research frameworks to structure the current state of research on the integration of SOA, BPM and BRM. The authors highlight the current research scope, point to disregarded topics and sketch out multidisciplinary research approaches. Findings While the three concepts are often discussed only in isolation or pairwise, approaches that integrate them are scarce. Against this backdrop, this study defines three types of research opportunities and identifies several directions for future research that should be explored from a technological as well as organizational perspective. Given the breadth of open questions, the authors present sources for each area of our research framework, which can serve as starting points for future investigations. Practical implications Except for well-established support for separate tasks and technologies, there is a lack of integrated standards, methods and platforms, which for example enable integrated decision-making across BPM and SOA. Originality/value Our contribution builds on established frameworks and clearly shows that the discussion on the integration of SOA, BPM and BRM cannot yet be regarded as sufficient. The research agenda highlights which areas explicitly benefit from a more precise consideration.
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Ou, Yang, Zheng Jiang Liu, Hamid Reza Karimi, and Ying Tian. "Multilevel Association Rule Mining for Bridge Resource Management Based on Immune Genetic Algorithm." Abstract and Applied Analysis 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/278694.

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This paper is concerned with the problem of multilevel association rule mining for bridge resource management (BRM) which is announced by IMO in 2010. The goal of this paper is to mine the association rules among the items of BRM and the vessel accidents. However, due to the indirect data that can be collected, which seems useless for the analysis of the relationship between items of BIM and the accidents, the cross level association rules need to be studied, which builds the relation between the indirect data and items of BRM. In this paper, firstly, a cross level coding scheme for mining the multilevel association rules is proposed. Secondly, we execute the immune genetic algorithm with the coding scheme for analyzing BRM. Thirdly, based on the basic maritime investigation reports, some important association rules of the items of BRM are mined and studied. Finally, according to the results of the analysis, we provide the suggestions for the work of seafarer training, assessment, and management.
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MARTINS, BÁRBARA ESTEVAM DE MELO, AMANDA ABDALLAH CHAIBUB, MARCIO VINICIUS DE CARVALHO BARROS CORTÊS, VALÁCIA LEMES DA SILVA LOBO, and MARTA CRISTINA CORSI DE FILIPPI. "CHARACTERIZATION OF BACTERIAL ISOLATES FOR SUSTAINABLE RICE BLAST CONTROL." Revista Caatinga 33, no. 3 (September 2020): 702–12. http://dx.doi.org/10.1590/1983-21252020v33n313rc.

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ABSTRACT Rice blast (Magnaporthe oryzae) limits rice (Oryza sativa) grain yields worldwide. The objective of this investigation was to morphologically, biochemically, and molecularly characterize six bacterial isolates, BRM 32109, BRM 32110, BRM 32111, BRM 32112, BRM 32113, and BRM 32114, and to determine their potential as antagonists to M. oryzae. Morphological characterization was based on colony formation and color, Gram staining, and fluorescent pigment production. Biochemical studies were based on cellulase, chitinase, phosphatase, indoleacetic acid, and siderophore production, as well as biofilm formation. The molecular identification used specific primers for PCR amplification of the 16S rRNA region, followed by sequencing. The antagonism studies involved three experiments, which had randomized designs. Two of them were conducted in laboratory conditions, pairing bacterial colonies and M. oryzae, using bacterial filtrates, and the third was conducted in greenhouse conditions. BRM 32111 and BRM 32112 were identified as Pseudomonas sp., BRM 32113 as Burkholderia sp., BRM 32114 as Serratia sp., and BRM 32110 and BRM 32109 as Bacillus spp. BRM 32112, BRM 32111, and BRM 32113 inhibited the colony of M. oryzae by 68%, 65%, and 48%, respectively. The bacterial suspensions of the BRM 32111, BRM 32112, and BRM 3212 filtrates suppressed leaf blast by 81.0, 79.2, and 66.3%, respectively. BRM 32111 and BRM 32112 were determined to be antagonists of M. oryzae and were found to solubilize phosphate, produce siderophores and cellulose, form biofilms, and suppress leaf blast. These isolates should be further investigated as potential biological control agents for leaf blast control.
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Park, Song Yi, Sang-Hwa Lee, Min-Jeong Kim, Ki-Hwan Ji, and Ji Ho Ryu. "Comparing the cut score for the borderline group method and borderline regression method with norm-referenced standard setting in an objective structured clinical examination in medical school in Korea." Journal of Educational Evaluation for Health Professions 18 (September 27, 2021): 25. http://dx.doi.org/10.3352/jeehp.2021.18.25.

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Purpose: Setting standards is critical in health professions. However, appropriate standard setting methods do not always apply to the set cut score in performance assessment. The aim of this study was to compare the cut score when the standard setting is changed from the norm-referenced method to the borderline group method (BGM) and borderline regression method (BRM) in an objective structured clinical examination (OSCE) in medical school.Methods: This was an explorative study to model of the BGM and BRM. A total of 107 fourth-year medical students attended the OSCE at seven stations with encountering standardized patients (SPs) and one station with performing skills on a manikin on 15 July 2021. Thirty-two physician examiners evaluated the performance by completing a checklist and global rating scales.Results: The cut score of the norm-referenced method was lower than that of the BGM (p<0.01) and BRM (p<0.02). There was no significant difference in the cut score between the BGM and BRM (p=0.40). The station with the highest standard deviation and the highest proportion of the borderline group showed the largest cut score difference in standard setting methods.Conclusion: Prefixed cut scores by the norm-referenced method without considering station contents or examinee performance can vary due to station difficulty and content, affecting the appropriateness of standard setting decisions. If there is an adequate consensus on the criteria for the borderline group, standard setting with the BRM could be applied as a practical and defensible method to determine the cut score for OSCE.
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Elfring, Lisa K., Carla Daniel, Ophelia Papoulas, Renate Deuring, Melinda Sarte, Sarah Moseley, Shelley J. Beek, et al. "Genetic Analysis of brahma: The Drosophila Homolog of the Yeast Chromatin Remodeling Factor SWI2/SNF2." Genetics 148, no. 1 (January 1, 1998): 251–65. http://dx.doi.org/10.1093/genetics/148.1.251.

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Abstract The Drosophila brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling factor SWI2/SNF2. Here, we report the phenotype of null and dominant-negative brm mutations. Using mosaic analysis, we found that the complete loss of brm function decreases cell viability and causes defects in the peripheral nervous system of the adult. A dominant-negative brm mutation was generated by replacing a conserved lysine in the ATP-binding site of the BRM protein with an arginine. This mutation eliminates brm function in vivo but does not affect assembly of the 2-MD BRM complex. Expression of the dominant-negative BRM protein caused peripheral nervous system defects, homeotic transformations, and decreased viability. Consistent with these findings, the BRM protein is expressed at relatively high levels in nuclei throughout the developing organism. Site-directed mutagenesis was used to investigate the functions of conserved regions of the BRM protein. Domain II is essential for brm function and is required for the assembly or stability of the BRM complex. In spite of its conservation in numerous eukaryotic regulatory proteins, the deletion of the bromodomain of the BRM protein has no discernible phenotype.
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Akash, D., N. Earanna, and S. Subramanya. "Mushroom diversity in the Biligiri rangana hills of Karnataka (India)." Journal of Applied and Natural Science 9, no. 3 (September 1, 2017): 1381–87. http://dx.doi.org/10.31018/jans.v9i3.1371.

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Evergreen forests of Biligiri rangana hills (BR hills) spread over an area of 540 sq. KM over eastern most edge of Western Ghats in Karnataka. Climatic conditions are more favorable for establishment of mushrooms and complete their life cycle. In this study, fourteen mushroom species were collected from BR hills region during monsoon (June through September 2013) with the help of Solega tribe inhabited the region since many years. Of the fourteen mushrooms, two mushrooms were identified as Ganoderma lucidum and Polyporous flabelliformis based on their phenotypic characters. The other 12 mushrooms were identified by ITS (Internal Transcribed spacer)region sequence homology as Termitomyces sp. (BRM-3)., Auricularia delicate (BRM-4), Termitomyces microcarpus (BRM-5), Amanita sp. (BRM-6), Podoscypha petalodes (BRM-7), Agaricaceae sp. (BRM-8), Macrolepiota sp.(BRM-9), Calvatia holothurioides (BRM-10), Gymnopillus crociphyllus (BRM-11), Coprinus comatus (BRM-12), Gyrodontium sacchari (BRM-13) and Clitocybeafffellea (BRM-14). Among the fourteen mushrooms, three species viz., Termito-myces species, Auricularia delicate and Termitomyces microcarpus were edible. The others were non edible/poisonous species. This study reports the diverse mushroom species as addition to biodiversity at BR hills.
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Dissertations / Theses on the topic "Brm"

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Aldén, Gustaf. "A pilot framework for BRM training." Thesis, Linnéuniversitetet, Sjöfartshögskolan (SJÖ), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-95155.

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Human error has been a key factor in grounding- and collision incidents in the past and continues to present a challenge to the maritime industry in the present day. The feasibility of a pilot framework for Bridge Resource Management (BRM) training lies at the heart of this study, its objective being to gauge the possibility of the construction of such a model. The result is thought to open up for further research and highlight the most relevant and effective BRM tools that can be used, by the bridge team, to prevent collision and grounding. The study was carried out in two stages. Firstly, four key personnel within the shipping industry were interviewed. These respondents were tasked with prioritising what they regarded as the most effective BRM tools. Secondly, the effectiveness of these tools was tested on marine incident cases. A document analysis was carried out on six collision and grounding cases, as investigated by the Marine Accident Investigation Branch (MAIB). The majority of the respondents were in agreement regarding which three BRM tools they regarded as the most relevant and effective. The result from the interviews was repeated in the result from the document analysis.  The conclusions that were drawn are that: it is possible to construct a pilot framework for BRM training and it is also possible to measure the effectiveness of the BRM tools. Additionally, suggestions for further research that arose from this thesis pertain to the study of the relationship between different BRM tools.
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Bock, Vanessa Leonie. "The Role of Brm, Brg-1, Snail 1 and Snail 2 in the Progression of Non-Melanoma Skin Cancer." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/4091.

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Non-melanoma skin cancer (NMSC) is the most common human cancer worldwide. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) make up almost all NMSC. SCC usually arises from actinic keratosis (AK) as a result of exposure to sunlight. SCC and AK provide a useful clinical model to investigate changes involved in the progression of NMSC. This project examines the expression of Brm, Brg-1, Snail 1 and Snail 2 in the progression of NMSC. Brm and Brg-1 are subunits of the SWI/SNF chromatin-remodelling complex which is involved in regulating the access of cell machinery to DNA by altering the structure of chromatin. It has been suggested that loss of this function is involved in carcinogenesis as the cell is unable to access to DNA normally in order to repair mutations or activate apoptosis. The loss of Brm or Brg-1 has been described in several human cancers. Snail 1 and Snail 2 are zinc-finger transcription factors that are known for their role in epithelial to mesenchymal transition (EMT), a process vital to embryological development. Increased expression of these factors leads to a loss of cell-cell adhesion and a migratory phenotype and has been described in some human cancers. In this project, double-label immunohistochemistry was used to determine the relative expression of these proteins in human SCC, BCC, AK and normal skin. The expression of Snail was unable to be determined due to poor specificity of the antibodies used. The expression of both Brm and Brg-1 proteins was found to be dramatically and consistently decreased in SCC and BCC when compared to normal skin and AK. This loss of Brm and Brg-1 occured as the tumour progressed from benign AK to malignant SCC. This finding suggests that the loss of either Brm or Brg-1 constitutes a key step in carcinogenesis. The results of this study identify Brm and Brg-1 as putative tumour suppressors involved in the progression of non-melanoma skin cancer from benign to malignant.
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Bock, Vanessa Leonie. "The Role of Brm, Brg-1, Snail 1 and Snail 2 in the Progression of Non-Melanoma Skin Cancer." University of Sydney, 2008. http://hdl.handle.net/2123/4091.

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Master of Medicine
Non-melanoma skin cancer (NMSC) is the most common human cancer worldwide. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) make up almost all NMSC. SCC usually arises from actinic keratosis (AK) as a result of exposure to sunlight. SCC and AK provide a useful clinical model to investigate changes involved in the progression of NMSC. This project examines the expression of Brm, Brg-1, Snail 1 and Snail 2 in the progression of NMSC. Brm and Brg-1 are subunits of the SWI/SNF chromatin-remodelling complex which is involved in regulating the access of cell machinery to DNA by altering the structure of chromatin. It has been suggested that loss of this function is involved in carcinogenesis as the cell is unable to access to DNA normally in order to repair mutations or activate apoptosis. The loss of Brm or Brg-1 has been described in several human cancers. Snail 1 and Snail 2 are zinc-finger transcription factors that are known for their role in epithelial to mesenchymal transition (EMT), a process vital to embryological development. Increased expression of these factors leads to a loss of cell-cell adhesion and a migratory phenotype and has been described in some human cancers. In this project, double-label immunohistochemistry was used to determine the relative expression of these proteins in human SCC, BCC, AK and normal skin. The expression of Snail was unable to be determined due to poor specificity of the antibodies used. The expression of both Brm and Brg-1 proteins was found to be dramatically and consistently decreased in SCC and BCC when compared to normal skin and AK. This loss of Brm and Brg-1 occured as the tumour progressed from benign AK to malignant SCC. This finding suggests that the loss of either Brm or Brg-1 constitutes a key step in carcinogenesis. The results of this study identify Brm and Brg-1 as putative tumour suppressors involved in the progression of non-melanoma skin cancer from benign to malignant.
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Farrell, Andrew William. "The Role of Brm in Non-­‐Melanoma Skin Cancer Progression." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16438.

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Background: Australia has the highest incidence of non-melanoma skin cancer (NMSC) in the world. These cancers are predominantly caused by exposure to ultraviolet radiation (UVR) in sunlight. Brm is an ATPase subunit that drives chromatin remodelling via the SWI/SNF complex. Thus, Brm is able to regulate access to transcription factors and repair enzymes to DNA, in addition to cell division. The loss of Brm has been observed in several cancer types, where its loss correlates with decreased patient survival. The loss of Brm has been identified in NMSC, but not pre-malignant lesions, suggesting Brm plays a role in the progression of a benign skin lesion into a malignant skin cancer. Brm-deficient mice also harbour excessive levels of epidermal hyperplasia as well as heightened tumour incidence following UVR as compared to mice with wildtype Brm. Moreover, a novel hotspot mutation of Brm (Q203K) has also been discovered in 17% of NMSC studied, which was the first mutation of Brm discovered in any type of cancer. Aims: This thesis aims to study the function of the Q203K mutation as compared to the loss of Brm in several key aspects of keratinocyte responses to UV-induced DNA damage: proliferation, cell cycle regulation, UVR-induced cell death and DNA repair. Methods: The loss of Brm was studied with keratinocytes grown ex vivo from neonatal Brm-/- mice and compared to keratinocytes grown from Brm+/+ mice. Further, a human keratinocyte cell line, HaCaT was also studied, in combination with Brm miRNAs to knockdown Brm expression in these cells. The overexpression of either wildtype or Q203K Brm was also studied in HaCaTs. These cells were treated with UV, and their responses were observed using assays for cell growth, cell death, cell cycle regulation and DNA repair. Results: In neonatal mouse keratinocytes, as well as HaCaT cells, the loss of Brm expression led to an altered cellular response to UVR. Cells lacking Brm exhibited increased proliferative potential following UVR due to a reduced time spent in G1 cell cycle arrest. Further, Brm-deficient cells displayed increased formation of UVR-induced cyclobutane pyrimidine dimers (CPDs) in the dark. Interestingly, when Brm was knocked down in the immortalised human keratinocyte cell line HaCaT, these cells were not as sensitive to the loss of Brm in combination with UVR, and showed less prominent effects on both cell cycle regulation and CPD formation. It was hypothesised that primary neonatal keratinocytes were more sensitive to UVR due to these cells being naïve, whereas HaCaT cells already exhibit several UVR-induced mutations, such as that of p53. Therefore, the loss of Brm in mouse neonatal keratinocytes was more catastrophic to the cell. Lastly, the mutation of Q203K did not lead to increased cellular sensitivity to UVR, suggesting the presence of this mutation in NMSC was most likely non-functional. However, increasing levels of Brm in HaCaT cells did lead to enhanced levels of cell viability at high density, which the Q203K mutation was able to reverse, suggesting Q203K does display some functionality, and thus may play a role in other functions not studied in this thesis. Conclusions: The loss of Brm but not the Q203K mutant in combination with UVR is enough to cause increased cellular sensitivity in the cell, leading to the proliferation of cells whilst harbouring DNA damage via defective cell cycle checkpoints. This would likely lead to heightened levels of mutations in the cell, and increased carcinogenesis downstream, as previously witnessed in Brm-deficient mice. The Q203K mutation was not comparable to the loss of Brm, and this thesis suggests that the Q203K mutation in NMSC is not likely to contribute to increased carcinogenesis, however further testing would have to be conducted to fully determine this.
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Oddgeirsson, Edmark Henrik. "Varje fartyg är unikt : Sjöbefäls upplevelser av BRM och hur det tränas." Thesis, Linnéuniversitetet, Sjöfartshögskolan (SJÖ), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-82489.

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Bridge Resource Management (förkortat BRM) är idag en naturlig del av handhavandet av fartyg, med syfte att öka säkerheten. Olyckorna till sjöss minskar däremot inte i den takt som de borde. Studien har därför ställt frågan om hur aktiva sjöbefäl upplever att träning i BRM kan förbättras för att bidra till ökad säkerhet, med icke-tekniska förmågor som teoretisk utgångspunkt. Slutsatsen är att inget fartyg är det andra likt när det gäller arbetet med BRM, och förhållandevis abstrakta egenskaper hos besättningen som inställning och beteende i kombination med praktisk nautisk kompetens och erfarenhet är nyckelkomponenter för fartygets säkra framförande. Varje tillfälle för BRM-träning bör också hanteras som unikt, framför allt utifrån deltagarnas specifika behov och bakgrund.
Bridge Resource Management (in short BRM) is today a natural part of ship handling, with its purpose of enhancing safety. The accidents, on the other hand, are not declining by a desired rate. This study has therefore posed the question of how working deck officers experience training in BRM and how it is contributing to safety. The theoretical basis is the concept of non-technical skills. The conclusion is that every vessel is unique when it comes to BRM. Seemingly abstract faculties as attitude and behavior shown by the crewmembers combined with practical, nautical competence and experience are key factors for safe ship handling. Every moment of BRM-training should be a unique event, and therefore arranged keeping the specific needs and background of the participants in mind.
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SCATTOLINI, DANIELE. "LA GESTIONE DELLA RELAZIONE NELLA SUPPLY CHAIN: DAL TRADE MARKETING AL BRM." Doctoral thesis, Università Politecnica delle Marche, 2016. http://hdl.handle.net/11566/243101.

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Il presente lavoro, sviluppato nell’ambito del dottorato di ricerca cofinanziato dal Gruppo Fileni, riguarda il rapporto tra l’industria e la distribuzione; nello specifico, si sviluppa nell’osservare quali azioni l’impresa di produzione può intraprendere per migliorare la relazione e la gestione della relazione stessa con le imprese commerciali. Nella tesi l’attenzione si è concentrata sul’evoluzione del marketing tradizionale, verso nuove forme di marketing relazionale, esaminando in particolare il trade marketing. L’aspetto innovativo è rappresentato, invece, dalle possibilità applicative del Buyer Relationship Management (BRM), evoluzione del CRM, con specifico riferimento al Gruppo Fileni. L’obiettivo principale è, pertanto, comprendere sotto quali condizioni organizzative e sotto quale approccio manageriale sia possibile implementare un percorso di sviluppo in grado di far conseguire alle imprese industriali risultati utili. La ricerca ha permesso di portare avanti, oltre ad una riflessione teorica sul rapporto industria-distribuzione, due indagini empiriche: la prima, basata sul metodo del caso di studio multiplo, ha rappresentato il supporto di verifica per l’analisi della tematica del trade marketing, analizzando quattro differenti best practices di aziende di calibro nazionale e internazionale; la seconda, basata sul metodo del caso di studio singolo, in una logica di action research, ha riguardato un esempio di percorso evolutivo da seguire per creare valore nella supply chain. Le due analisi presentano interessanti implicazioni teoriche e operative. A livello teorico, la prima ha consentito di arricchire con interessanti contributi la tematica del trade marketing; la seconda, invece, di concettualizzare un modello innovativo, il BRM, capace di avanzare gli studi in materia di CRM. A livello operativo, invece, le indagini offrono utili indicazioni ai manager sul percorso da seguire per migliorare la relazione e, soprattutto, la gestione del rapporto con le imprese commerciali.
This work, developed within PhD studies co-financed by the Fileni Group, addresses the issue of the relationship between the supplier and the retailer. More specifically, the present study investigates which supplier actions are suitable for improving the management of relationships with retailers. This thesis focuses on the evolution of the traditional concept of marketing towards new forms of relationship marketing, examining in particular trade marketing. The innovative aspect of this work is the possible application to the Fileni Group of Buyer Relationship Management (BRM), which is a development of CRM. The main objective is, from the supplier’s perspective, to understand which organizational conditions and managerial approach will encourage progressive development and hence lead to good performance. In addition to a theoretical discussion on the supplier-retailer relationship, this work also allowed two empirical studies to be carried out: the first, based on the multiple case study method, confirms the relevance of the trade marketing literature and analyzes four different best practices adopted by national and international companies; the second, which uses the single case study method and ongoing action research, presents an example of development which can create supply chain value. The two analyses have interesting theoretical and operational implications. The first empirical analysis has, to a certain extent, contributed to existing literature by updating studies on the subject of trade marketing, while the second study has allowed an innovative model, the BRM, to be implemented, which is capable of furthering CRM studies. From a more operational point of view, the analyses may provide supplier managers with considerable insight not only into how to enhance relationships with retailers but, above all, into how to improve the management of these relationships.
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Sut, Caroline. "Détermination des prédicteurs de sévérité des effets indésirables receveurs au cours des transfusions de concentrés plaquettaires." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSES061/document.

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La transfusion sanguine est une thérapeutique indispensable pour laquelle il n’existe pas actuellement de substitut. La transfusion de produits sanguins labiles est dans la grande majorité des cas très bien tolérée mais elle peut être à l’origine d’effets indésirables chez les receveurs (EIR) notamment de type inflammatoire. Ceci dépend de facteurs liés aux produits eux-mêmes et/ou aux receveurs de par leur prédisposition génétique et de leur état clinique. Les concentrés plaquettaires (CP) sont la principale source de manifestations inflammatoires et/ou allergiques. Ceci est notamment dû, en partie, à la capacité des plaquettes à sécréter une multitude de molécules ayant une activité inflammatoire. De plus, les processus de collecte, de préparation et de conservation induisent un stress vis-à-vis des cellules, qui peut activer les plaquettes et donc induire la production de produits inflammatoires dans les CP. Le but de ce travail de thèse a été dans un premier temps d’identifier les molécules les plus impliquées dans les manifestations inflammatoires. Le sCD40L en particulier est identifié comme étant largement impliqué dans les EIR après transfusion de CP, mais pas systématiquement. Aussi, la composante inflammatoire de ces réactions est multifactorielle. De plus, nous avons évalué le potentiel inflammatoire des CP sur l’endothélium vasculaire. Des différences d’activation des cellules endothéliales, dans un modèle in vitro, ont été observées lorsqu’elles sont en présence de surnageants de CP ayant induits un EIR. Ce travail de thèse poursuit l’effort entrepris par notre équipe de recherche, en vue de prédire la survenue d’EIR et de préciser les mécanismes qui influencent la physiopathologie plaquettaire transfusionnelle ; un corollaire de ces travaux est ainsi d’optimiser les processus de production et de conditionnement des CP transfusés afin de réduire ces réactions inflammatoires
Blood transfusion is an indispensable therapy for which there is currently no substitute. Transfusion of blood products is in the great majority of cases very well tolerated but it can be at the origin of serious adverse reactions (SARs), notably of inflammatory reactions. This depends on the factors related to the products themselves and/or to the recipients, their genetic predisposition and clinical condition. Platelet concentrates (PCs) are the main source of inflammatory and/or allergic manifestations. This is due, in part, to the ability of platelets to secrete a multitude of molecules with inflammatory activity. In addition, the collection, processing and storage conditions induce stress on cells, which can activate platelets and thus induce the production of inflammatory products in PCs. The purpose of this work is to identify the molecules involved in inflammatory manifestations. sCD40L was identified as being involved in SARs after PCs transfusion, but not systematically. Also, the inflammatory component of these reactions is multifactorial. In addition, we evaluated the inflammatory potential of PCs on the vascular endothelium. Differences in endothelial cell activation, in an in vitro model, were observed when they were in the presence of PC supernatants involved in SARs. This thesis work continues the effort undertaken by our research team to predict the occurrence of SARs and to clarify the mechanisms that influence transfusional platelet physiopathology; a corollary of this work is to optimize the production and conditioning process of PCs transfused in order to reduce these inflammatory reactions
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Zhang, Min. "The role of SWI/SNF in regulating smooth muscle differentiation." Thesis, Connect to resource online, 2009. http://hdl.handle.net/1805/2024.

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Thesis (Ph.D.)--Indiana University, 2009.
Title from screen (viewed on December 1, 2009). Department of Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): B. Paul Herring, Anthony B. Firulli, Frederick M. Pavalko, Simon J. Rhodes. Includes vitae. Includes bibliographical references (leaves 138-149).
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Krzystyniak, Joanna. "Epigenetic modulation of intestinal homeostasis and tumorigenesis by Brm SWI/SNF chromatin remodelling factor." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/73083/.

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SWI/SNF chromatin remodelling complexes are one of the well-characterized cellular machineries capable of regulation of gene expression. Numerous lines of evidence indicate that SWI/SNF complexes are involved in a wide range of cellular processes and the maintenance of homeostasis whereas aberrant expression of those proteins contributes towards cancer development. Colorectal cancer remains one of the most clinically significant cancers due to its high incidence in developed countries and previous studies have demonstrated that SWI/SNF complexes are aberrantly regulated in a significant proportion of patients with this disease. However, whilst the sequence of molecular events leading to CRC has been well-established, the role of SWI/SNF chromatin remodelling complex ATPase subunits Brm and its paralogue Brg1 in the colorectal tumorigenesis remains elusive. The chromatin remodelling catalytic subunit Brm has been found to interact with the Notch pathway effectors ICD-22 and CBF-1 and also to be necessary for expression of the Wnt target gene CD44 and for Rb-mediated cell cycle arrest. In this PhD thesis, the potential of Brm to modulate Wnt-driven intestinal tumorigenesis was addressed. Initially, a murine model carrying constitutively deleted Brm was used to assess the consequences of this loss on homeostasis of the small intestinal and colonic epithelia. The effects of Brm deficiency were also examined in the context of Wnt-activated epithelium via conditional loss of Apc. Additionally, the effect of concomitant loss of Brm and Brg1 was addressed in the contexts of both normal homeostasis and aberrant Wnt signalling. The results presented here demonstrate that Brm plays an important role in the small intestine by regulating the distribution of proliferating cells and cell fate decisions mediated through Notch pathway effectors. Furthermore, Brm deficiency was found to modulate intestinal phenotype of Wnt activation through the attenuation of the Wnt transcriptional programme and the suppressed expression of the intestinal stem cell marker Olfm4. Thus while Brg1 has been widely characterized as a bone fide tumour suppressor, the function of Brm continues to remain elusive especially in the light of contrasting effects co-mediated by Brm on proliferation, differentiation and gene expression. Taken together, these results elucidate the tissue-specific role of Brm, the catalytic subunit of SWI/SNF chromatin remodelling complex, on both normal intestinal homeostasis and acute activation of Wnt pathway while the extent of these Brm-dependent effects depend upon the gradient of Wnt signalling throughout the epithelium of small and large intestine.
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Pantak, N. "Hitting the target but missing the point : Merseyside Police's response to the BRM satisfaction gap." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3010080/.

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The study is an evaluation of how Merseyside Police attempted to narrow the Black and Racial Minority (BRM) satisfaction gap, as measured by the Home Office performance indicator. The research considers the sense with which both police officers and, more importantly, victims made of the policies and processes used. It asks whether this activity resulted in an improvement to the service being provided, therefore benefitting the victim, or in the construction of performance data thereby benefitting the organisation. The research was undertaken between 2011 and 2015 and completed as a case study. It involved the views of those people within Merseyside Police who were responsible for the design and implementation of policy along, with some of those responsible for delivering the service to the public. The research also includes the narrative of victims who had taken part in Merseyside Police’s monthly victim satisfaction survey. The BRM satisfaction gap was initially proposed by the Macpherson Report, which had examined the murder of black teenager Stephen Lawrence. It was one of ten performance indicators intending to monitor and assess whether trust and confidence in the police was improving within BRM communities. Previous research had identified factors other than the quality of police contact as influencing a person’s level of satisfaction. However, this research shows how the BRM satisfaction gap was treated as a single subject by Merseyside Police, who chose to focus purely on service delivery to improve victim satisfaction. Warnings regarding statistical relevance of the BRM satisfaction gap, along with concerns as to whether the victim satisfaction survey was fit for purpose, were ignored in their efforts to ensure the performance indicator was on target. The research highlights how New Public Management (NPM) principles of performance management were used to produce organisational focus and develop a system which closely tracked the service provided to BRM victims by individual officers. However, it shows that although it resulted in a good knowledge amongst senior officers, this was not embedded amongst those delivering the service. Instead, reporting officers developed their own working practices to deliver Merseyside Police’s required ‘Gold Service’ to BRM victims, whilst many victims remained confused and frustrated with the service provided. Merseyside Police did statistically narrow the BRM satisfaction gap. However, the research highlights the influence of performance construction and questions whether the recorded improvement in performance was as result of an improved service or was manufactured by gaming techniques. Although the BRM satisfaction gap was intended to measure trust and confidence, the research concludes this was never a consideration for Merseyside Police who, instead, focussed their efforts on improving their performance indicator.
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Books on the topic "Brm"

1

Nye, Doug. BRM: The saga of British Racing Motors. Croydon: MRP, 1991.

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Wasielewski, Maciej. Bim, bam, bom, mogę wszystko!: Historia Bogusława Meca. Warszawa: Agora S.A., 2013.

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Crosswell, Adrian Brian. Investigations into lead and silver refining undertaken during the BRM/Brunel University Teaching Company scheme. Uxbridge: Brunel University, 1991.

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Keller, Anna. Bim, Bam y Bum. Bucaramanga, Colombia: Fundación El Libro Total, 2009.

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Infante, Arturo. Bim Bom: Historias de lucha. Madrid: Diábolo Ediciones, 2016.

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1885-1954, Jenkins Billy, and United States. National Aeronautics and Space Administration., eds. Complex burn region module (BRM) update: Final technical report for the period November 01 1989 through September 30, 1990. [Washington, DC: National Aeronautics and Space Administration, 1991.

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Al-Jahwari, Nasra Ahmed. Investigation on teamwork or groupwork expectation to performance and social loafing among the BRM students of the business school. Oxford: Oxford Brookes University, 2002.

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illustrator, Iwai Melissa, ed. Bim and Bom: A Shabbat tale. Minneapolis: Kar-Ben, 2011.

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ill, Ephraim Shelly Schonebaum, ed. Bim and Bom: A Shabbat tale. Rockville, MD: Kar-Ben Copies, 1996.

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Division, Montana Highways. Environmental assessment and final section 4(f) evaluation for BRM 5211(2), 9th-10th Streets North (connector) Bridge, Great Falls, Montana. Helena, Mont: U.S. Dept. of Transportation, Federal Highway Administration, Region 8 [and] State of Montana Dept. of Transportation, Highways Division, 1992.

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Book chapters on the topic "Brm"

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Saidak, Zuzana, Zakaria Ezzoukhry, Jean-Claude Maziere, Antoine Galmiche, Ken-Ichi Takemaru, Xingwang Chen, Feng-Qian Li, et al. "BRM." In Encyclopedia of Signaling Molecules, 203. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100139.

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Hohwiller, Jörg, Diethelm Schlegel, Gunter Grieser, and Yvette Hoekstra. "Integration of BPM and BRM." In Lecture Notes in Business Information Processing, 136–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-25160-3_12.

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Wan, Li, Bo Huang, Xiang Ling, and Guoqing Wu. "BRM—A Behavior Based Requirements Modeling Method." In Advances in Intelligent and Soft Computing, 1139–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-03718-4_139.

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Abe, Shigeru, Megumi Ohnishi, Sadao Kimura, Masatoshi Yamazaki, Haruyuki Oshima, Denichi Mizuno, and Hideyo Yamaguchi. "BRM Activities of Low-Toxic Bordetella Pertussis Lipopolysaccharides." In Microbial Infections, 69–76. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3434-1_8.

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Machida, Yuichi, Yujin Inayoshi, Kiyohito Murai, Katsuhide Miyake, and Shinji Iijima. "A Chromatin Remodeling Factor, BRM has Important Roles in Cell Differentiation." In Animal Cell Technology: Basic & Applied Aspects, 303–7. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-0728-2_54.

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Kato, Motohisa, Kiichi Miya, and Shigetoyo Saji. "Effects of Serial Transarterial Infusion Chemotherapy Combination with Multi-BRM for Metastatic Liver Tumor." In Recent Advances in Management of Digestive Cancers, 711–13. Tokyo: Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-68252-3_213.

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Itoh, Toshinari, Katsuhide Miyake, and Shinji Iijima. "CCAAT/Enhancer-Binding Protein Beta Controls Differentiation-Specific Expression of Chromatin Remodeling Factor BRM." In Animal Cell Technology: Basic & Applied Aspects, 203–9. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-9646-4_32.

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Kusama, Mikihiro, Kozaburo Kimura, Yasuhisa Koyanagi, and Kazunobu Suzuki. "Suppression of Cytokines Production in Peripheral and Regional Lymph Node Lymphocytes from Patients with Gastric Cancer and the Augmentative Effect of BRM." In Recent Advances in Management of Digestive Cancers, 394–96. Tokyo: Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-68252-3_107.

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Chaubey, Vikas P., Kevin B. Laupland, Christopher B. Colwell, Gina Soriya, Shelden Magder, Jonathan Ball, Jennifer M. DiCocco, et al. "B2M." In Encyclopedia of Intensive Care Medicine, 281. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1187.

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Ormö, Jens. "Brim." In Encyclopedia of Planetary Landforms, 1–2. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-9213-9_28-2.

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Conference papers on the topic "Brm"

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Reisman, David N., Colin Rogers, and Geoff Liu. "Abstract 1590: BRM and BRM polymorphisms applications for target therapy." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1590.

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Kahali, Bhaskar, Sarah Gramling, and David N. Reisman. "Abstract 4609: Epigenetic regulation of BRM." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4609.

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Lee, Shih-Hsiung, and Chu-Sing Yang. "PSO ICA with BRM for Image Enhancement." In 2016 International Symposium on Computer, Consumer and Control (IS3C). IEEE, 2016. http://dx.doi.org/10.1109/is3c.2016.87.

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Raimondi, Lucrezia, Laura Di Benedetto, Paolo Ciracì, Rachele Lazzeroni, Filippo Maria Raimondi, Gian Paolo Spinelli, and Giuseppe Naso. "CIRCULATING TUMOR DNA OF CEREBROSPINAL FLUID SAMPLES IN TRIPLE-NEGATIVE BREAST CANCER: USEFULNESS OF LONGITUDINAL ASSESSMENT FOR EARLY DETECTION OF BRAIN METASTASIS." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2008.

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Objectives: Triple-negative breast cancer (TNBC) still has poor prognosis for a higher rate of relapse and a greater tendency of developing brain metastasis (BrM) compared with other major breast cancer subtypes. Circulating tumor DNA (ctDNA) represents a valuable tool associated with the outcome and the aggressiveness of breast cancer. Biomarkers allowing to predict the development of BrM in TNBC are needed. We studied the usefulness of assessment of CSF-ctDNA for identification early at-risk patients to develop BrM in TNBC. Methodology: A total of 323 newly diagnosed nonmetastatic TNBC patients who underwent neoadjuvant therapy + surgery (NACT) with complete response (CR) were prospectively enrolled. After surgery, CSF-ctDNA collected from all patients enrolled was extracted and assessed using the QIAamp Circulating Nucleic Acid Kit. Survival curves were estimated by using Kaplan–Meier method and compared with the log-rank test. Multivariate Cox regression was used to identify the risk of mortality at 3 years. Results: After NACT, CSF-ctDNA was detectable in 126/323 (39%) patients, 101/126 (80%) were diagnosed at Stage 3. A total of 124 out of 126 (98.4%) ctDNA+ patients subsequently developed BrM. In contrast, only 2 (2/197, 1%) ctDNA− patients subsequently developed BrM and 195 other patients remain in a CR (p <0.001, Fisher’s exact test). CSF-ctDNA did associate with PFS and OS: undetectable ctDNA was associated with superior PFS (HR 0.3; p=0.002) and OS (HR 0.2; p<0.01), indicating survival is largely determined by the onset of BrM. With a median follow-up of 3 years, median PFS of ctDNA+ versus ctDNA− patients was 13 months versus not reach, p=0.004 (log-rank test). Median OS for ctDNA+ versus ctDNA− patients was 16 months after NACT versus not reach, p=0.0016 (log-rank test). At multivariate analysis, detectable CSF-ctDNA emerged as the best predictor of the development of BrM and 24-month mortality (HR: 3.62; p <0.0001). Age, stage, Ki67%, and response to chemotherapy were not significantly associated with the prognosis. Conclusion: After NACT, detectable CSF-ctDNA significantly associated with PFS and OS, identifying early at-risk patients to develop BrM in TNBC who should take advantage from appropriate additional treatment, remains a critical problem.
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Rogers, Colin, Geoffrey Liu, Daniela Munoz, Dangxiao Cheng, Azad K. Kalam, Maryam Mirshams, Zhou Chen, et al. "Abstract 198: Two novel insertion polymorphisms of the BRM gene are associated with loss of BRM expression and lung cancer risk." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-198.

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Yasui, Kohichiroh, Yasuyuki Gen, Akira Tomie, Tomoko Kitaichi, and Yoshito Itoh. "Abstract 5186: Reduced expression of BRM in hepatocellular carcinoma." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5186.

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Tipsuwanporn, V., F. Cheevasuvit, W. Piyarat, P. Thepsatorn, and Y. Paraken. "BRM technique for space vector decomposition reactive power of SPIM." In Proceedings of the IEEE 1999 International Conference on Power Electronics and Drive Systems. PEDS'99 (Cat. No.99TH8475). IEEE, 1999. http://dx.doi.org/10.1109/peds.1999.794623.

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Savija, I., J. R. Culham, and M. M. Yovanovich. "Effective Thermophysical Properties of Thermal Interface Materials: Part II — Experiments and Data." In ASME 2003 International Electronic Packaging Technical Conference and Exhibition. ASMEDC, 2003. http://dx.doi.org/10.1115/ipack2003-35264.

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A new method for determining effective thermal conductivity and Young’s modulus in thermal interface materials is demonstrated. The method denoted as the Bulk Resistance Method (BRM) uses empircal thermal resistance data and analytical modeling to accurately predict thermophysical properties that account for insitu changes in material thickness due to external loading and thermal expansion. The BRM is demonstrated using commercially available sheets of Grafoil GTA. Tests were performed on thermal joints consisting of two Al 2024 machined surfaces with layers of Grafoil GTA in the interface. Test conditions included a vacuum environment, 0.2–6.5 MPa contact pressure, a nominal 50°C mean interface temperature and a continuous loading and unloading cycle. Test results indicated that the BRM consistently predicted thermal conductivity independent of the number of layers tested and that the predicted results were significantly lower than values reported using conventional ASTM test procedures.
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Matsubara, Daisuke, Yuka Kishaba, Shumpei Ishikawa, Masashi Fukayama, and Toshiro Niki. "Abstract 2179: Histopathologic and genetic features of lung adenocarcinomas with loss of chromatin remodeling factors, BRG-1 and BRM." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2179.

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He, Shu-Wen, Shinn-Dar Wu, Ting Huang, and Yu-Hong Wen. "Research on the practice of pesticide knowledge BRM board game in primary school." In ICDLT 2021: 2021 5th International Conference on Deep Learning Technologies. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3480001.3480003.

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Reports on the topic "Brm"

1

Smith, Horace, William Broste, and Carl Ekdahl. A Diamagnetic-Loop-Based Beam Radius Monitor (BRM). Office of Scientific and Technical Information (OSTI), July 2021. http://dx.doi.org/10.2172/1808820.

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Smith, Horace, William Broste, Howard Bender, Nicholas Kallas, Kurtis McCurdy, David Moir, Manolito Sanchez, Gary Salazar, Wade Ogg, and Carl Ekdahl. Installation and Testing of a Diamagnetic-Loop-Based Beam Radius Monitor (BRM) on the DARHT-I Linear Induction Accelerator. Office of Scientific and Technical Information (OSTI), January 2023. http://dx.doi.org/10.2172/1922735.

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O'Donnell, James T., Tobias Maile, Cody Rose, Natasa Mrazovic, Elmer Morrissey, Cynthia Regnier, Kristen Parrish, and Vladimir Bazjanac. Transforming BIM to BEM: Generation of Building Geometry for the NASA Ames Sustainability Base BIM. Office of Scientific and Technical Information (OSTI), January 2013. http://dx.doi.org/10.2172/1168736.

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Benmerrouche, Mo. 06-BM BMM Beamline Radiation Shielding Analysis. Office of Scientific and Technical Information (OSTI), May 2017. http://dx.doi.org/10.2172/1493172.

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Benmerrouche, Mo. 06-BM BMM Beamline Radiation Shielding Analysis - Revised. Office of Scientific and Technical Information (OSTI), July 2017. http://dx.doi.org/10.2172/1493174.

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Yan, Jianxun, and Dan Dale. TRIUMF BLM. Office of Scientific and Technical Information (OSTI), January 2019. http://dx.doi.org/10.2172/1490793.

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Barner, Claudine Eckert, and Kristen Morris. Newton Bra. Ames: Iowa State University, Digital Repository, September 2016. http://dx.doi.org/10.31274/itaa_proceedings-180814-1610.

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Pinayev, Igor. BPM Button Testing. Office of Scientific and Technical Information (OSTI), July 2018. http://dx.doi.org/10.2172/1480939.

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Church, M. BPM System Improvements. Office of Scientific and Technical Information (OSTI), April 1991. http://dx.doi.org/10.2172/983980.

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Deshpande, Alina. BRD usability requirements. Office of Scientific and Technical Information (OSTI), March 2015. http://dx.doi.org/10.2172/1172866.

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