Dissertations / Theses: 'Brg-1'

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Bock, Vanessa Leonie. "The Role of Brm, Brg-1, Snail 1 and Snail 2 in the Progression of Non-Melanoma Skin Cancer." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/4091.

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Non-melanoma skin cancer (NMSC) is the most common human cancer worldwide. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) make up almost all NMSC. SCC usually arises from actinic keratosis (AK) as a result of exposure to sunlight. SCC and AK provide a useful clinical model to investigate changes involved in the progression of NMSC. This project examines the expression of Brm, Brg-1, Snail 1 and Snail 2 in the progression of NMSC. Brm and Brg-1 are subunits of the SWI/SNF chromatin-remodelling complex which is involved in regulating the access of cell machinery to DNA by altering the structure of chromatin. It has been suggested that loss of this function is involved in carcinogenesis as the cell is unable to access to DNA normally in order to repair mutations or activate apoptosis. The loss of Brm or Brg-1 has been described in several human cancers. Snail 1 and Snail 2 are zinc-finger transcription factors that are known for their role in epithelial to mesenchymal transition (EMT), a process vital to embryological development. Increased expression of these factors leads to a loss of cell-cell adhesion and a migratory phenotype and has been described in some human cancers. In this project, double-label immunohistochemistry was used to determine the relative expression of these proteins in human SCC, BCC, AK and normal skin. The expression of Snail was unable to be determined due to poor specificity of the antibodies used. The expression of both Brm and Brg-1 proteins was found to be dramatically and consistently decreased in SCC and BCC when compared to normal skin and AK. This loss of Brm and Brg-1 occured as the tumour progressed from benign AK to malignant SCC. This finding suggests that the loss of either Brm or Brg-1 constitutes a key step in carcinogenesis. The results of this study identify Brm and Brg-1 as putative tumour suppressors involved in the progression of non-melanoma skin cancer from benign to malignant.

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Bock, Vanessa Leonie. "The Role of Brm, Brg-1, Snail 1 and Snail 2 in the Progression of Non-Melanoma Skin Cancer." University of Sydney, 2008. http://hdl.handle.net/2123/4091.

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Master of Medicine
Non-melanoma skin cancer (NMSC) is the most common human cancer worldwide. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) make up almost all NMSC. SCC usually arises from actinic keratosis (AK) as a result of exposure to sunlight. SCC and AK provide a useful clinical model to investigate changes involved in the progression of NMSC. This project examines the expression of Brm, Brg-1, Snail 1 and Snail 2 in the progression of NMSC. Brm and Brg-1 are subunits of the SWI/SNF chromatin-remodelling complex which is involved in regulating the access of cell machinery to DNA by altering the structure of chromatin. It has been suggested that loss of this function is involved in carcinogenesis as the cell is unable to access to DNA normally in order to repair mutations or activate apoptosis. The loss of Brm or Brg-1 has been described in several human cancers. Snail 1 and Snail 2 are zinc-finger transcription factors that are known for their role in epithelial to mesenchymal transition (EMT), a process vital to embryological development. Increased expression of these factors leads to a loss of cell-cell adhesion and a migratory phenotype and has been described in some human cancers. In this project, double-label immunohistochemistry was used to determine the relative expression of these proteins in human SCC, BCC, AK and normal skin. The expression of Snail was unable to be determined due to poor specificity of the antibodies used. The expression of both Brm and Brg-1 proteins was found to be dramatically and consistently decreased in SCC and BCC when compared to normal skin and AK. This loss of Brm and Brg-1 occured as the tumour progressed from benign AK to malignant SCC. This finding suggests that the loss of either Brm or Brg-1 constitutes a key step in carcinogenesis. The results of this study identify Brm and Brg-1 as putative tumour suppressors involved in the progression of non-melanoma skin cancer from benign to malignant.

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STROBECK, MATTHEW WILLIAM. "THE ROLE OF CHROMATIN REMODELING IN RB-MEDIATED CELL CYCLE ARREST." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1014728057.

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Modén, Roger, and Tomas Johansson. "Konstruktionsberäkning enligt Eurokoder : Bro 17-1294-1." Thesis, Karlstad University, Faculty of Technology and Science, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4108.

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Brabin, Charles Edward. "Investigating the regulation and functioning of RNT-1 and BRO-1 in C. elegans." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:6d9cd263-1051-443a-b064-c0c329252b28.

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The stem cell-like seam cells of the nematode, Caenorhabditis elegans, represent a tractable and powerful model for studying stem cell biology. rnt-1, the worm homologue of the mammalian RUNX family of transcription factors, together with the CBFβ homologue bro-1, is essential for the proliferation of the seam cells. RUNX genes and CBFβ are important regulators of stem cell development in mammals, and are associated with a variety of cancers. The worm seam cell model offers an opportunity to examine how these genes function in stem cell biology. The aim of this work was to shed light on the genetic network in which bro-1 and rnt-1 function, and to reveal the identity of regulators of these genes as well the downstream targets of the bro-1/rnt-1 pathway. Here, a number of genes that interact with bro-1 and rnt-1 have been identified. ELT-1, a GATA transcription factor, is shown to be a direct regulator of bro-1. Findings which show that the MEIS gene unc-62 acts upstream of bro-1/rnt-1 and regulates the symmetry of seam cell divisions are also presented. The seam cell marker, scm::gfp, is widely used in studies of the seam cells; here the results of an investigation into its identity and functional links are described. In addition, the mechanism underlying spatial regulation of rnt-1 was examined; this led to the discovery of distinct tissue-specific enhancer modules within an intron of this gene. Finally, interactions between pal-1 and bro-1/rnt-1 are reported and described. Together, these findings provide a framework for furthering our understanding of the mechanisms and genes associated with the functioning of bro-1 and rnt-1 in the worm.

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Grönqvist, Oskar. "Förstärkning av bro 17-803-1 : En jämförelse av förstärkningsmetoder." Thesis, Karlstads universitet, Fakulteten för teknik- och naturvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-8156.

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Schonemann, Marcus Dieter. "The role of the class III POU domain proteins, Brn-1 and Brn-2 in vertebrate development /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9806514.

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Saad, Nicole Liliane. "Investigating the role of rnt-1 and bro-1 in seam cell proliferation in C elegans." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531996.

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Lind, Karolina. "Vad är frivilligt sex? : Om frivilligt deltagande enligt 6 kap 1 § BrB." Thesis, Uppsala universitet, Juridiska institutionen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423095.

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Andersson, Jonas, David Nyqvist, and Johan Persson. "En dator per elev - bra eller inte? En kvantitativ analys av hur lärare förhåller sig till 1:1 konceptet." Thesis, Örebro universitet, Handelshögskolan vid Örebro Universitet, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-65162.

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Mirédin, Kim. "The Transcriptional Repressor CC2D1A/Freud-1 Interacts with the Chromatin Remodeling Protein Brg1." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23148.

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The serotonin-1A (5-HT1A) receptor plays an important role in the regulation of the serotonin (5-HT) system as an autoreceptor on 5-HT neurons. The transcription factor CC2D1A/Freud-1 is a potent repressor of the 5-HT1A promoter in neuronal but not in non-neuronal cells. The clinical relevance of Freud-1 is evident in a naturally occurring mutation, resulting in a truncated form of Freud-1 lacking its C-terminal half, that is associated with non syndromic mental retardation in humans. Thus, it is of interest to clarify the structure and function of Freud-1. As Freud-1 was shown to interact with the transcriptional regulator Brg1 at the 5-HT1A promoter, identification of the structural domains mediating the Brg1/Freud-1 interaction is required to assess the role of Brg1 in Freud-1 repression. In this study, I used pull-down assays with recombinant proteins, co-immunoprecipitation studies and immunofluorescent staining with confocal microscopy to show that Freud-1 interacts directly with the C-terminus of Brg1 and that the C-terminal domain of Freud-1 is required for this interaction.

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Tunborg, Jacob. "Provokation som grund för strafflindring : Om tillämpningen av 29:3 p. 1 BrB." Thesis, Uppsala universitet, Juridiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219454.

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Wardak, Rustam. "Utvecklingen av samspelet mellan lagstiftare och rättstillämpare : En studie av 3 kap. 1 § BrB." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-92980.

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Walla, David. "Molecular Regulation of Synaptogenesis in Drosophila." Thesis, University of Oregon, 2014. http://hdl.handle.net/1794/18392.

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Dynamic regulation of the actin cytoskeleton is required for synapses to form and maintain their shape. The actin cytoskeleton is regulated by Rho GTPases in response to genetic and extracellular signals. Rho GTPases are regulated by guanine nucleotide exchange factors and GTPase activating proteins (GAPs). Syd-1 is a protein that has been identified as necessary for synapse formation in worms, with similar proteins in flies, and mice. Little is known about the molecular mechanism by which Syd-1 is acting. While genetic techniques are great tools for examining synapse development, they are limited by their inability to consider the molecular nature of the protein product. By studying the biochemical nature of synaptic proteins, we can begin to understand their function with a new level of clarity. Syd-1 has a predicted Rho GAP domain; however it is thought to be inactive. The activity of the fly protein, Dsyd-1, has never been examined although it has been speculated that it is inactive in all invertebrates. Recently the mouse version was reported to have Rho GAP activity. By performing GTPase activity assays on purified proteins, I found the GAP domain of Dsyd-1 increased the GTPase activity of Rac-1 and Cdc42 but not RhoA. Members of our lab found the activity of Dsyd-1 is necessary for proper synapse formation both at the Drosophila neuromuscular junction as well as in R7 neurons. In Caenorhabditis elegans, Syd-1 was found to interact with presynaptic protein RSY-1. Since RSY-1 is evolutionarily conserved, I tested whether or not RSY-1 has a similar effect on R neurons in Drosophila. I also isolated mRNA from R neurons and evaluated the possibility of analyzing mutant neurons using comparative transcriptomics. This dissertation includes previously unpublished coauthored material.

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Lehmkuhl-Dakhwe, K. Virginia. "Regulation of p53, p21, ARF, BIM, and BAX by the Transcription Factor Trip-Br1." Ohio University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1194549826.

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Kupreeva, Inna Veniaminovna. "Alexander of Aphrodisias on soul as form (de anima 1-26 Br.)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0021/NQ41200.pdf.

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Hedlund, Jessica. "Otydliga rekvisit i BrB 4 kap. 1 a § om människohandel : Tolkningsproblem i frågan om kontroll och otillbörliga medel." Thesis, Karlstad University, Faculty of Economic Sciences, Communication and IT, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-1798.

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The thesis will discuss the interpretations of the two requisites; Control and improper means in the paragraph concerning trafficking in human beings, who can be find in the Swedish penal code chapter 4, section. 1 a. This paragraph is worded in a way that indicates that the paragraph is misinterpreted and that it is therefore hard to proof that the present requisites have been used or fulfilled. However, Sweden has by accepting international legal framework committed itself to do anything in its power to prevent, suppress and punish trafficking in persons. The interpretation of the paragraph has shown that the difficulties have mainly depended of its indistinct formula.

A new review published in April 2008 shows that the paragraph should be afforded a new wording, and therefore contain new requisites. For criminal liability of trafficking in human beings the current requisite about control is interpreted along with the use of improper means. Control is taken with the aim to use the victim for trafficking. This requisite is consequently removed from the suggestion that the review publishes. The requisite about improper means are though still in the paragraph, mainly to show that violation of the personal integrity are greater that the violation of sexual integrity. One of the problems concerning the prosecution in cases with great resemblance to trafficking are often prosecuted as procuring.

Firstly, the current legal status of the paragraph is examined, by the preparatory work, mainly carried out by the Swedish government. This shows in which way the requisites where meant to be interpreted, and which relation the Swedish ordinance have to the international instruments and documents. Secondly, I present the court cases that have been discussing these requisites in there judicial decision. This shows how they are worded and which problems the legal systems see in these requisites. Furthermore I present the new review and their interpretation of the legal situation, and their conclusion is that the paragraph should be afforded with a new wording. Finally I discuss the likely outcome of these changes, with the background of the work material presented in this thesis.

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Jedemark, Jakob. "Kvinnlig provokation : en diskursanalys av det kvinnliga brottsoffrets beteende som provocerande enligt BrB 29 kap. 3 § p. 1." Thesis, Stockholms universitet, Juridiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-127678.

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Edström, Matilda. "”Kanske mår tjuvarna inte bra” : Ett skönlitterärt verks didaktiska potential för arbete med skolans värdegrund i årskurs 1." Thesis, Linnéuniversitetet, Institutionen för svenska språket (SV), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-100914.

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Denna studie syftar till att undersöka den didaktiska potentialen för värdegrundsarbete i Stora Boken om Sandvargen (2006) skriven av Åsa Lind. Syftet är även att, med elever i årskurs 1, undersöka hur förståelse för skolans värdegrund kan skapas med hjälp av boksamtal kring Stora Boken om Sandvargen. För att undersöka detta analyseras verket utifrån fenomenologisk och socialkonstruktivistisk teori. Analysen görs även i förhållande till två utvalda delar ur Läroplan för grundskolan, förskoleklassen och fritidshemmet 2011 (2019) (”Skolans värdegrund och uppdrag”). Resultatet av analysen konstaterar att Stora Boken om Sandvargen har stor didaktisk potential för arbete med skolans värdegrund. Verket används sedan i boksamtal utformade efter Aidan Chambers modell, för att undersöka om och i så fall hur eleverna visar förståelse för skolans värdegrund. Boksamtalen analyseras i förhållande till de två utvalda delarna ur styrdokumenten och slutsatsen blir att eleverna på ett flertal sätt visar förståelse för skolans värdegrund. Resultatet visar hur eleverna skiftar perspektiv mellan sitt eget, karaktärer i berättelsen samt andra människor i elevernas liv och att kunna skifta och bredda sina perspektiv anses i studien vara grundläggande för skolans värdegrundsarbete.

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Lundell, Madeleine. "Vad behövs för en bra teknikundervisning? : En studie om hur pedagoger ser på teknikundervisning för åk 1-3." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-84409.

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The purpose of the study is to contribute with knowledge about technology teaching for years 1-3 by gaining better knowledge of what educators perceive about their technology teaching regard to interest, understanding and assessment. The study has used semi-structured interviews as a method, involving four educators. The study examines how educators, who teach technology in primary school, consider their teaching in terms of interest, understanding and assessment. The results showed a great interest in the subject and the teaching. What affects teaching is the knowledge the educator possesses, the availability of teaching materials and construction materials and how time is allocated. Assessment opportunities are also affected by the educator's knowledge and by the student groups. The teachers' view of the purpose of their teaching turns out to be the same as they assess, which is the students' commitment and ability to reflect. There is uncertainty among teaching educators, including how to interpret the curriculum and design lesson arrangements. This uncertainty may be the reason why the subject is still taught together with the nature-oriented subjects, where the educators feel more confident. The study revealed shortcomings in the availability of teaching materials, materials for construction and further education. The educators consider these assets to be a prerequisite for being able to practice good teaching. Increased knowledge and access to materials could be a way of developing teaching. Knowledge through further education and collegial learning helps educators to feel confident in how to interpret the curriculum and achieve an equal education. The availability of materials for construction could be increased through collaboration with the practically oriented subjects such as handicrafts and painting as well as with extracurricular at school.
Syfte med studien är att bidra med kunskap om teknikundervisning för åk 1-3 genom att få bättre kännedom om vad pedagoger uppfattning om sin teknikundervisning med avseende på intresse, förståelse och bedömning. Studien har använt semistrukturerade intervjuer som metod, där fyra pedagoger medverkade. Studien undersöker hur pedagoger som undervisar i teknik på lågstadiet, tänker om sin undervisning med avseende på intresse, förståelse och bedömning. Resultatet visade ett stort intresse för ämnet och undervisningen. Det som inverkar på undervisning är den kunskap pedagogen besitter, tillgången på läromedel och konstruktionsmaterial samt hur tiden disponeras. Även bedömningsmöjligheter påverkas av pedagogens kunskap samt av elevgruppernas sammansättning. Pedagogernas syfte med undervisningen visar sig vara samma som de bedömer, vilket är elevernas engagemang och reflektionsförmåga. Även om pedagogerna till stor del är positiva till att undervisa i ämnet teknik finns det en osäkerhet om bland annat i hur de ska tolka läroplanen och utforma lektionsupplägg. Denna osäkerhet kan vara orsaken till att ämnet fortfarande undervisas ihop med de naturorienterande ämnena, där pedagogerna känner sig säkrare. I studien framkom det att pedagogerna upplever brister i tillgången på läromedel, material för konstruktion samt fortbildning. Dessa tillgångar anser pedagogerna vara en förutsättning för att kunna utöva en bra undervisning. Kunskap genom fortbildning och kollegialt lärande hjälper pedagogerna att känna sig trygga i hur de ska tolka läroplanen och få till en likvärdig undervisning. Tillgången till material för konstruktion skulle kunna utökas genom samarbete med de praktiskt inriktade ämnena som slöjd och bild samt med fritids på skolan.

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Alonso, Marcell Patachi. "Características agronômicas de genótipos de amendoim forrageiro em resposta à intensidade e ao intervalo de desfolhação." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-06042018-150612/.

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As pastagens são a base da alimentação dos ruminantes na pecuária brasileira. Sistemas de produção em condições pastoris utilizam diversos genótipos forrageiros sob diferentes formas de manejo, no intuito de otimizar respostas produtivas desses sistemas. Algumas decisões quanto ao manejo, no entanto, são tomadas de forma não criteriosa e generalista, tornando o sistema de produção frequentemente propenso a erros na gestão. A intensificação da produção animal em pastagem possibilita o aumento da participação de leguminosas forrageiras no sistema. No entanto, ainda há um limitado entendimento das respostas destas plantas quando submetidas a manejos mais intensificados. Este trabalho teve como objetivo caracterizar quatro cultivares comerciais de Arachis pintoi Krapov. & Greg., sob duas intensidades de desfolhação e dois intervalos entre desfolhas ao longo da estação de crescimento de dois anos consecutivos. Para tanto, foi conduzido um experimento analisando-se os cultivares Alqueire-1, Amarillo, Belmonte e BRS Mandobi sob quatro manejos de colheita: dois intervalos (28 e 35 dias) associados a duas intensidades de desfolha (5 e 10 cm). Determinou-se a produtividade total por estação de crescimento, acúmulo total de forragem, taxa de acúmulo diário, composição morfológica, ângulo foliar, interceptação luminosa, índice de área foliar, composição química e digestibilidade da forragem, fotossíntese foliar, fotossíntese de dossel e compostos orgânicas de reserva. O experimento foi conduzido no município de Piracicaba - SP, sendo a área experimental total de 0,11 ha. O delineamento experimental adotado foi o inteiramente casualizado com arranjo em parcelas subdivididas. À parcela foram alocados as combinações entre cultivares de A. pintoi (Alqueire-1, Amarillo, Belmonte e BRS Mandobi) e intervalos entre cortes (28 e 35 dias) em um fatorial 4 x 2. À subparcela foi designado o fator intensidade de desfolhação, na forma de duas alturas de resíduo (5 e 10 cm), tendo o experimento contado com com 3 repetições. A análise estatística dos dados foi realizada utilizando-se o procedimento MIXED do SAS®. As médias dos tratamentos foram estimadas utilizando-se o LSMEANS e comparadas pelo teste Tukey a 5% de probabilidade. O cultivar Belmonte apresentou média de acúmulo total acima de 11,85 Mg MS ha-1 e taxa de acúmulo diário de 41 kg MS ha-1 nos diferentes manejos adotados, sendo o maior desempenho produtivo em relação aos demais cultivares testados. Em geral, o intervalo de 28 dias com intensidade de desfolha de 5 cm, confere maior produtividade total aos cultivares de A. pintoi. Menores produções de folíolos, pecíolos e estolões foram obtidos para o cultivar Amarillo.O perfil nutricional do cultivar Belmonte apresentou maior potencial em função da alta concentração de proteína bruta (277 g kg-1 MS) e digestibilidade in vitro da matéria orgânica (717 g kg-1 MS) em relação a Alqueire-1 e Amarillo e concentrações de fibra em detergente neutro (366 g kg-1 MS) intermediárias comparativamente aos três cultivares. Variações intraespecífica entre os cultivares apresenta pouco efeito sobre os compostos de reservas, sendo estes mais afetados pelas estratégias de manejo adotadas. Carboidratos totais não estruturais estiveram menos concentrados nos órgãos de reserva de Alqueire-1 (196 g kg-1 MO), e a concentração de N total apresentou variação somente entre os cultivares Belmonte (31 g kg-1 MO) e BRS Mandobi (25 g kg-1 MO). Em geral, a concentração de carboidratos totais não estruturais nos órgãos de reserva é maior quando o manejo de intervalos entre desfolha é de 35 dias. Plantas invasoras são mais evidentes em dosséis manejados com intensidade de desfolha de 5 cm. O cultivar Belmonte apresenta características que lhe conferem maior desempenho agronômico, sendo portanto considerado o material mais promissor.
Pastures are the backbone of the brazilian livestock industry. Pasture-based ruminant production systems make use of a diverse base of forage genotypes under various managements, aiming at the optimization of productive responses. Decisions regarding management, however, are often made under an empirical and generalistic standpoint, making these systems prone to failure. The intensification of animal production on pasture makes can be achieved with the increased participation of forage legumes in the system. However, there is still a limited understanding of the responses of these plants when subjected to more intensive management. This work aimed to characterize four commercial cultivars of Arachis pintoi (Krapov. & Greg.), under two harvest intensities and two harvest intervals throughout the summer growing season of two years. An experiment was carried out with the cultivars Alqueire-1, Amarillo, Belmonte and BRS Mandobi under four harvest management: two intervals (28 and 35 days) associated with two harvest intensities (5 and 10 cm). The total forage accumulation, daily accumulation rate, plant-part composition, leaf angle, light interception, leaf area index, chemical composition and forage digestibility, leaf photosynthesis, canopy photosynthesis and organic reserve compounds. The experiment was carried out in Piracicaba - SP. The experimental design was completely randomized with split-plot arrangement. To the plots were allocated the combinations between cultivars of A. pintoi (Alqueire-1, Amarillo, Belmonte and BRS Mandobi) and harvest intervals (28 and 35 days) in a factorial 4 x 2. To the subplot was designated harvest intensities (5 and 10 cm). Data were analyzed using the MIXED procedure of SAS®. Treatment means were estimated using LSMEANS and compared by the Tukey test at 5% of probability. Belmonte had mean of total accumulation above 11.85 Mg DM ha-1 and daily accumulation rate of 41 kg DM ha-1 in the different managements adopted, the greatest production of all four entries. In general, the 28 day interval with harvest intensity of 5 cm resulted in greater total yield of all cultivars. The nutritional profile of Belmonte was the best due to the high concentration of crude protein (277 g kg-1 DM) and in vitro digestible of organic matter (717 g kg-1 DM) relative to Alqueire-1 and Amarillo and neutral detergent fiber concentrations (366 g kg-1 DM) as compared to the three cultivars. Intraspecific variations among cultivars had less effect on the reserve compounds, being more affected by the management strategies. Total non-structural carbohydrate concentratin was less in Alqueire-1 roots and stubble (196 g kg-1 OM), and total N concentration differed only between Belmonte (31 g kg-1 OM) and BRS Mandobi (25 g kg-1 OM). In general, the concentration of total non-structural carbohydrates in the reserve organs is greater when intervals between harvest is 35 days. Weeds are more evident in canopies managed with harvest intensity of 5 cm. Belmonte seems to have greater agronomic performance, being therefore considered the most promising material.

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Falk, Urs. "Bilineare und biquadratische Austauschwechselwirkungen in den gemischten Systemen CsMn-xMg(1-x)Br-3 /." Zürich, 1986. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7886.

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Ozdemir, Halise. "An Attempt To Understand Humes Philosophy Of Religion." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607086/index.pdf.

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Norman, David Andrew. "Studies on nuclear factor KAPPA and a related protein, 1 KAPPA BR, in cardiac myocytes." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251661.

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Bitzer, Julia [Verfasser], and Oliver [Akademischer Betreuer] Gruss. "Molecular characterization of the breast cancer associated antigen NY-BR-1 / Julia Bitzer ; Betreuer: Oliver Gruss." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/118073520X/34.

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Zahedi, Farhad, Richard Korswagen, and Manfred L. Ziegler. "Reacciones de H7 -C7H7W(COh X (X=Br, 1) con aniones organometálicos del IV grupo principal." Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/101310.

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En el presente trabajo describimos el estudio de estas reacciones aplicadas a la preparación de derivados del sistema TpW (CO)z -L (L =ligando organometálico con elementos del IV grupo principal), con el objeto de comparar el componarniento del sistema del tungsteno con el del molibdeno, en parte estudiado por nosotros anteriormente.
We report the reactions of TpW(COh X (Tp = h7-C7H 7, X = Br, 1)with thc anionic species MPh3 - (Ph = C6 Hs ; M= Ge, Sn, Pb) leading to thesubstitution products TpW(C0hMPh3 (3). The compound 3d (M= Pb) couldnot be isolated due to its instability and was only detected spcctroscopically;3b (M= Ge) and 3c (M = Sn) were isolated as red crystals and caracterizedthrough elemental analysis and spectrometry (IR, 1H-NMR and MS).The reduction of TpW(COhl with Na/Hg in THF leads to the an10n[TpW (COhr (1), which also reacts with MPh3- (M = Si, Ge, Sn) forming3a (M = Si), 3b and 3c; 3a was detected only spectroscopically.

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Bitzer, Julia Verfasser], and Oliver [Akademischer Betreuer] [Gruss. "Molecular characterization of the breast cancer associated antigen NY-BR-1 / Julia Bitzer ; Betreuer: Oliver Gruss." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/118073520X/34.

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Drwal, Veronika [Verfasser], and Thomas [Akademischer Betreuer] Wex. "Die Bedeutung der Expression der G-Protein-gekoppelten-Rezeptoren BRS 3, CCKA, CXCR 4, GHRH, GRPR, NK 1, NMBR, NT 2, PAC 1, VPAC 1 und VPAC 2 bei kolorektalen Tumoren in Abhängigkeit von Tumorstadium und Differenzierungsgrad / Veronika Drwal. Betreuer: Thomas Wex." Magdeburg : Universitätsbibliothek, 2012. http://d-nb.info/1054135525/34.

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Cotta, Aloísio José Bueno. "Estudo da homogeneidade e atribuição de valores e incertezas certificados a um material de referencia de basalto (BRP-1 Basalto de Ribeirão Preto)." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/286803.

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Orientador: Jacinta Enzweiler
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Geociencias
Made available in DSpace on 2018-08-08T13:45:46Z (GMT). No. of bitstreams: 1 Cotta_AloisioJoseBueno_M.pdf: 787013 bytes, checksum: 13b0b9b7761deb7be37a9a3b6857b626 (MD5) Previous issue date: 2007
Resumo: Materiais de referência (MRs) são usados para controlar e garantir a qualidade de resultados analíticos, além disso, são essenciais para calibrar instrumentos usados em análises de amostras de matriz complexa. Apesar de existirem várias dezenas de MRs de rochas, poucos são totalmente apropriados a essas finalidades. Dada a inexistência de MRs de rochas preparados no Brasil, um projeto colaborativo entre pesquisadores da UNICAMP/UNESP/CPRM/USGS/IAG foi elaborado em 2004, para a produção de 2 MRs de rochas. Os objetivos desta dissertação são descrever a preparação do primeiro desses materiais (BRP-1, Basalto de Ribeirão Preto) e estabelecer valores de referência conforme as recomendações do Guia 35 da ISO. O basalto BRP-1 apresenta elevado teor de titânio e de elementos-traço, o que o diferencia de outros MRs. A amostra (180 kg) foi fragmentada (< 5 cm) e enviada para o USGS (Denver, USA), onde ela foi moída (98% < 75µm). O pó foi homogeneizado e dividido em 1920 frascos, cada um com 55 g. De volta ao Brasil, a homogeneidade entre frascos foi avaliada por WDXRF. Os resultados das análises mostraram que os elementos maiores, menores e quatorze traços são suficientemente homogêneos. Adicionalmente, a massa mínima representativa para os principais constituintes de BRP-1 foi determinada por µ-SXRF, com um feixe de 1 mm2. Os resultados deste estudo indicam que os elementos maiores (Si, Ti, Fe, Ca e K) e traços (Ba, Co, Cu, Mn, Rb, Sr, Zn e Zr) são homogêneos em porções de 1 mg e 12 mg, respectivamente. A caracterização química foi efetuada em 18 laboratórios internacionais, selecionados com base no seu desempenho em teste proficiência organizado pela IAG. Adicionalmente, 12 laboratórios nacionais também foram convidados a analisar a amostra. Cada laboratório recebeu dois frascos de BRP-1 e um MRC para controle de qualidade (CQ). O protocolo analítico requisitava três resultados para cada frasco de BRP-1 e pelo menos um resultado do CQ. Até abril de 2007, os 18 laboratórios internacionais e 8 nacionais enviaram seus resultados, com os quais puderam ser calculados valores de referência e incertezas para 44 constituintes de BRP-1. O cálculo de cada valor de referência incluiu dados de comprovada rastreabilidade obtidos em 10 ou mais laboratórios, utilizando no mínimo duas técnicas analíticas. Nestes casos, a média das médias de cada laboratório foi tomada como valor de referência. As incertezas destes valores são, em geral, menores que 1/3 da incerteza de Horwitz. Adicionalmente, valores informativos para 11 elementos-traço são apresentados. Desta forma, BRP-1 é adequado aos usos previstos de um MRC.
Resumo: Materiais de referência (MRs) são usados para controlar e garantir a qualidade de resultados analíticos, além disso, são essenciais para calibrar instrumentos usados em análises de amostras de matriz complexa. Apesar de existirem várias dezenas de MRs de rochas, poucos são totalmente apropriados a essas finalidades. Dada a inexistência de MRs de rochas preparados no Brasil, um projeto colaborativo entre pesquisadores da UNICAMP/UNESP/CPRM/USGS/IAG foi elaborado em 2004, para a produção de 2 MRs de rochas. Os objetivos desta dissertação são descrever a preparação do primeiro desses materiais (BRP-1, Basalto de Ribeirão Preto) e estabelecer valores de referência conforme as recomendações do Guia 35 da ISO. O basalto BRP-1 apresenta elevado teor de titânio e de elementos-traço, o que o diferencia de outros MRs. A amostra (180 kg) foi fragmentada (< 5 cm) e enviada para o USGS (Denver, USA), onde ela foi moída (98% < 75µm). O pó foi homogeneizado e dividido em 1920 frascos, cada um com 55 g. De volta ao Brasil, a homogeneidade entre frascos foi avaliada por WDXRF. Os resultados das análises mostraram que os elementos maiores, menores e quatorze traços são suficientemente homogêneos. Adicionalmente, a massa mínima representativa para os principais constituintes de BRP-1 foi determinada por µ-SXRF, com um feixe de 1 mm2. Os resultados deste estudo indicam que os elementos maiores (Si, Ti, Fe, Ca e K) e traços (Ba, Co, Cu, Mn, Rb, Sr, Zn e Zr) são homogêneos em porções de 1 mg e 12 mg, respectivamente. A caracterização química foi efetuada em 18 laboratórios internacionais, selecionados com base no seu desempenho em teste proficiência organizado pela IAG. Adicionalmente, 12 laboratórios nacionais também foram convidados a analisar a amostra. Cada laboratório recebeu dois frascos de BRP-1 e um MRC para controle de qualidade (CQ). O protocolo analítico requisitava três resultados para cada frasco de BRP-1 e pelo menos um resultado do CQ. Até abril de 2007, os 18 laboratórios internacionais e 8 nacionais enviaram seus resultados, com os quais puderam ser calculados valores de referência e incertezas para 44 constituintes de BRP-1. O cálculo de cada valor de referência incluiu dados de comprovada rastreabilidade obtidos em 10 ou mais laboratórios, utilizando no mínimo duas técnicas analíticas. Nestes casos, a média das médias de cada laboratório foi tomada como valor de referência. As incertezas destes valores são, em geral, menores que 1/3 da incerteza de Horwitz. Adicionalmente, valores informativos para 11 elementos-traço são apresentados. Desta forma, BRP-1 é adequado aos usos previstos de um MRC.
Mestrado
Geologia e Recursos Naturais
Mestre em Geociências

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Andersson, Susanne. ""Det är bra att det är lika för alla" : -En intervjustudie om lärares uppfattningar om Skolverkets obligatoriska bedömningsstöd i läsutveckling för årskurs 1." Thesis, Linköpings universitet, Institutionen för beteendevetenskap och lärande, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148866.

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Den här kvalitativa intervjustudien beskriver hur ett tiotal lärare i de lägre skolåren resonerar kring Skolverkets obligatoriska bedömningsstöd i läsutveckling för årskurs 1. Studien fokuserar på lärarnas uppfattningar om organisation, upptäckter och resonemang kring stöden. Tio lärare har intervjuats med samma intervjuguide som bas. Urvalet av intervjupersoner är ett målstyrt bekvämlighetsurval bestående av lärare som har erfarenhet att arbeta med bedömningsstöden i läsning. Intervjuerna har transkriberats och analyserats med inspiration av tematisk analys. Resultatet av studien visar att lärarna är positivt inställda till bedömningsstödet. De tycker att de fått en bra bild av både enskilda elevers och gruppen/ klassens läsförmågor genom att genomföra bedömningsstöden. Resultatet av bedömningsstöden har använts för både summativ och formativ bedömning. Lärarna i studien resonerar mer kring upptäckter av elever i behov av extra stimulans än de resonerar kring upptäckter av elever i behov av anpassningar eller stöd. Den aspekt som lärarna är mest kritiska över vad gäller bedömningsstödet i läsning är den tidsåtgång som krävs för att genomföra dem. De betonar vikten av en bra organisation kring stöden för att kvaliteten på klassens undervisning inte ska bli lidande under den period som stöden genomförs.

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Rapin, Jean-Philippe. "Synthèse et étude cristallochimique de quelques aluminates et ferrites calciques hydratés de formule [Ca2 M(OH)6]+, [X,nH2O]- avec X=Cl, Br, I, ClO4, 1/2CO3 1/2CrO4 et 1/2SO4 et M=Al et Fe." Nancy 1, 2001. http://docnum.univ-lorraine.fr/public/SCD_T_2001_0124_RAPIN.pdf.

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Ce travail porte sur la synthèse et l'étude cristallographique de quelques aluminates et ferrites de calcium hydratés de formule structurale [Ca2Al1-xFex(OH)6]+ [X, nH2O]-, appelés "phase AFm" par les cimentiers. Ces composés appartiennent à la famille des hydroxydes doubles lamellaires (HDL) et sont formés par l'empilement de feuillets rigides chargés positivement, entre lesquels diverses espèces anioniques peuvent être insérées. La transition structurale de la phase AFm-Cl, a pour origine une organisation du réseau de liaisons hydrogène. Les structures cristallographiques de nombreuses phases, AFm-(Cl, Br), AFm-(Cl, CO3), AFm-(Cl, SO4) et AFm-(CrO4) ont été résolues. Une application de la phase AFm-Cl comme détecteur d'iodure par voltampérométrie a été réalisé. L'étude des ferrites de calcium a montré qu'une solution solide Al et Fe existe. Cependant la substitution de Al3+ par Fe3+ engendre des perturbations structurales mises en évidences par spectrométrie Mössbauer et EXAFS
This work deals with the synthesis and the crystallographic study of some calcium aluminate and calcium ferrite with structural formulae [Ca2Al1-xFex(OH)6]+ [X, nH2O]-, commonly named "AFm phases" by the cement workers. These compounds belong to the layered double hydroxide (LDH) family and are composed by the stacking of positively charged main layers, and negatively charged interlayers. It was shown that the structural transition of the AFm-Cl phase is due to an ordering of the hydrogen bonds network. The crystallographic structures of several phases, AFm-(Cl, Br), AFm-(Cl, CO3), AFm-(Cl, SO4) and AFm-(CrO4) are given. An application of AFm-Cl like iodide sensor by voltammetric detection is detailed. Finally, calcium ferrite study has shown that a solid solution between aluminium and iron exists. However the substitute of Al3+ by Fe3+ gives some structural modifications, which are clearly emphasised by Mössbauer spectrometry and EXAFS

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Minolf, Lisa, and Fanny Gustafsson. "”Huvudsaken är väl att man är en bra människa” : En kvalitativ textanalys av innehåll gällande könsmönster, könsidentitet och sexualitet i skönlitteratur för årskurs 1-3." Thesis, Uppsala universitet, Institutionen för pedagogik, didaktik och utbildningsstudier, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-433869.

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Studiens syfte är att synliggöra vilket innehåll gällande könsmönster, könsidentitet och sexualitet som finns i skönlitteratur för årskurs 1–3, för att lågstadielärare potentiellt ska kunna använda böckerna i ett högläsningssyfte i sin sex- och samlevnadsundervisning. Studiens teoretiska utgångspunkter är den didaktiska frågan vad, heteronormen, könsmönster, könsidentitet och sexualitet. Studien baseras därmed på tre forskningsfrågor angående vad i utvalda högläsningsböcker för årskurs 1–3 som är normavvikande och normativt inom könsmönster, könsidentitet och sexualitet. Detta undersöks genom en kvalitativ textanalys med analysfrågor formulerade utifrån studiens frågeställningar. De fyra böckerna som analyseras är följande: Prinsessan som inte tyckte om prinsar av Alice Brière-Haquet, Jösta och Johan av Anette Skåhlberg, Om jag bara inte råkat klippa taxfrisyr av Ingelin Angerborn och Brorsan är kung av Jenny Jägerfeld. Resultatet visar att majoriteten av karaktärerna beskrivs med både normavvikande och normativa könsmönster och att enstaka karaktärer är traditionellt normativa. Innehåll om könsidentitet påvisar att normativa könsidentiteter (cispersoner) är vanligast förekommande och att endast en karaktär identifierar sig med en normavvikande könsidentitet som transperson. Angående innehållet av sexualitet (sexuella läggningar) synliggörs normativ heterosexualitet i alla böcker och i två av böckerna synliggörs en normavvikande sexualitet, homosexualitet. Sammanfattningsvis visar resultatet att alla böckers innehåll genomsyras av normativa aspekter gällande könsmönster, könsidentitet och sexualitet, trots att de valts ut i ett normkritiskt perspektiv. Detta påvisar att heteronormen upprätthålls i samtliga böcker samtidigt som den utmanas av vissa karaktärer. Studien konstaterar därav att lärare bör vara medvetna i val av högläsningsbok samt vilket innehåll som förmedlas till eleverna, för att skolans sex- och samlevnadsundervisning ska normalisera det avvikande och därmed förmedla allas lika värde och rättigheter i likhet med skolans värdegrund.

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Larsson, Carolina, and Isabelle Lindstam. "“Jag sjunger hellre än bra...” : En kvalitativ studie om arbetet i förskolan med musik i åldrarna 1–3 år och hur förskollärare upplever ordet musikalisk." Thesis, Högskolan för lärande och kommunikation, Högskolan i Jönköping, Förskolepedagogisk-didaktisk forskning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-44506.

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Syftet med denna studie är att synliggöra på vilka sätt förskollärare arbetar med musik mot yngre barn i åldrarna 1–3 år samt hur förskollärarna ser på musikalitet i arbetet med barnen. De frågeställningarna som vi har besvarat för att uppnå syftet är: På vilka sätt arbetar förskollärarna mot de yngre åldrarna (1–3 år) med musik? Och hur beskriver förskollärarna betydelsen av att vara musikalisk i användandet av musik? Studien har genomförts med kvalitativa intervjuer. Förskollärarna valdes ur ett bekvämlighetsurval där någon av oss haft kontakt med deltagaren tidigare. Datainsamlingen är analyserad ur ett sociokulturellt perspektiv med fokus på redskap och den proximala utvecklingszonen. Resultatet visar att förskollärarna använder musiken på många sätt i utbildningen, de använder den bland annat spontant men även i planerade situationer i undervisningen. I det sociokulturella perspektivet talas det om redskap, förskollärarna använder sig av instrument, sång och rörelse och de förklarar att dessa kan vara redskap för bland annat språkutveckling och utvecklingen av barnens motorik. Förskollärarnas syn på musikalitet i arbetet med barnen är att man inte behöver vara musikalisk, så länge glädje visas inför att utöva musik tillsammans med barnen.

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Erguig, Hassane. "Contribution à l'étude des spectres de réflexion et de piézoréflexion de l'iodure cuivreux cui et des halogenures mixtes de plomb Pb CL2x Br2(1-x)( 0." Metz, 1990. http://docnum.univ-lorraine.fr/public/UPV-M/Theses/1990/Erguig.Hassane.SMZ9024.pdf.

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Dans la première partie de ce mémoire, nous décrivons la réalisation d'un montage de réflexion et piézoréflexion. Il permet la mesure de la variation relative de la lumière réfléchie par un échantillon soumis à une pression alternative en fonction de l'énergie de la lumière incidente aux basses températures et dans le domaine du visible. Dans la seconde partie, nous étudions les spectres de piézoréflexion des monocristaux de cui au voisinage de l'exciton 1sz#1#2 à 95 k. Le vecteur d'onde de la lumière incidente est perpendiculaire au plan de clivage (11) et les pressions alternatives sont appliquées suivant les directions 001, 011 et 111. Nous avons observé la décomposition de l'exciton transverse #5 et des petites structures de l'exciton #3+#4 interdites à pression nulle. Par analyse des spectres mesurés, nous avons déterminé les potentiels de déformation de la bande excitonique. Les potentiels hydrostatique (c-a)=1 ev, quadratique b=0,5 ev et triclinique d=1,8 ev. Dans la dernière partie, nous étudions les spectres de réflexion des monocristaux des halogénures mixtes de plomb Pb Cl2x Br2(1-x)( 0

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Streicher, Hermann. "Statistisch-klinische Notizen über die vom 1. October 1876 bis 1. Januar 1885 an der medicinischen Klinik zu Freiburg i. Br. zur Beobachtung gekommenen Fälle von Pleuritis exsudativa UB Freiburg, Hs. 1420; Autograph /." Freiburg i. Br. : Univ.-Bibl, 2006. http://www.manuscripta-mediaevalia.de/hs/katalogseiten/HSK0547%5Fb249%5Fjpg.htm.

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Arbstig, Holm Louise, and Norén Ulrika Hedman. "Undervisningen i förskoleklass och i årskurs 1 ska vara så bra att eleverna vaccineras mot lässvårigheter : En fördjupad förståelse av finska och svenska speciallärares arbete för att främja läsinlärningen." Thesis, Mälardalens högskola, Akademin för utbildning, kultur och kommunikation, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-35615.

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Syftet med denna studie är att fördjupa förståelsen av finska och svenska speciallärares arbete för att främja läsinlärningen. Nutidens samhälle kräver en god läs- och skrivförmåga. Det innebär en utmaning för pedagoger och speciallärare i skolan att verkligen se till att samtliga elever får de verktyg som är nödvändiga för att nå såväl en god läsförståelse som en god avkodningsförmåga. Under de senaste åren har det skrivits om Finlands goda resultat vad gäller läsning hos elever i grundskolan. Det fick oss som speciallärarstuderande att undra över vilka de finska framgångsfaktorerna var. Även olika orsaker till elevers svårigheter gällande läsutveckling tas upp samt speciallärarnas roll för att möta hinder i läsinlärningen. Finska och svenska styrdokument lyfts. För att genomföra studien har ett kvalitativt perspektiv använts med semistrukturerade intervjuer som metod. Fokus för undersökningen har varit att undersöka hur fjorton speciallärare i Finland och Sverige [1]beskriver sitt arbete med att identifiera elever i behov av särskilt stöd gällande läsinlärning samt hur de beskriver sitt dagliga arbete med elever i behov av särskilt stöd gällande läsinlärning. Även likheter och skillnader som framträtt i dessa beskrivningar belyses. Resultatet har analyserats utifrån en fenomenografisk analysmodell med utgångspunkt i studiens frågeställningar samt utifrån ett komparativt perspektiv. Ett par slutsatser som kan dras av studien är att det framkom en likhet som innebar att samtliga informanter hade elevens behov i fokus samt en skillnad mellan informanterna som berörde informanternas utbildningsbakgrund. [1] De finska informanterna har alla en speciallärarutbildning och hade en speciallärartjänst. Med finska speciallärare avses finska speciallärare verksamma i svensktalande skolor i Finland. Två av de svenska informanterna hade speciallärarutbildning och två hade specialpedagogutbildning. Tre av de svenska informanterna studerade till speciallärare. Alla svenska informanter hade tjänst som speciallärare. Samtliga svenska informanter benämns som svenska speciallärare. Benämningarna gäller genom hela studien.

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Gardyan, Adriane [Verfasser], and Stefan [Akademischer Betreuer] Eichmüller. "Identification of CD4+ T cell epitopes specific for the breast cancer associated tumor antigen NY-BR-1 using HLA-transgenic mice / Adriane Gardyan ; Betreuer: Stefan Eichmüller." Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/1180499123/34.

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Roy, Marilyne. "DEVENIR SERVITEUR DE LA PAROLE: Une anthropologie de la réception de la parole à la lumière d'une lecture sémiotique du récit de la dernière Cène (Luc 22, 1-62)." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28340/28340.pdf.

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Das, Krishna [Verfasser], and Stefan [Akademischer Betreuer] Eichmüller. "Generation of a transplantable murine tumor model expressing the human breast cancer associated tumor antigen NY-BR-1 in HLA-DRB1*0401-transgenic mice / Krishna Das ; Betreuer: Stefan Eichmüller." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178009513/34.

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Das, Krishna [Verfasser], and Stefan B. [Akademischer Betreuer] Eichmüller. "Generation of a transplantable murine tumor model expressing the human breast cancer associated tumor antigen NY-BR-1 in HLA-DRB1*0401-transgenic mice / Krishna Das ; Betreuer: Stefan Eichmüller." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178009513/34.

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Ganame, Noufou. "Place et rôle du ministère diaconal dans l'Église des Assemblées de Dieu du Burkina Faso : apport et critique de l'Église primitive selon Actes 6, 1-7." Doctoral thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/36442.

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"Le ministère du diacre occupe une place intégrante depuis les origines de l’Église des Assemblées de Dieu du Burkina Faso jusqu’à nos jours (1921-2017). Lorsque le missionnaire américain sillonnait les contrées pour l’annonce de l’Évangile, une fois qu’il enregistrait sur la place un solide noyau de chrétiens, il établissait un diacre à qui il donnait les prérogatives de pasteurs, car ceux-ci se faisaient rares. Nous pouvons affirmer qu’en plus de l’action du Saint-Esprit, la fondation de l’Église des Assemblées de Dieu du Burkina Faso repose sur la vie, les biens et les compétences de plusieurs de nos patriarches qui ont exercé le ministère de diacre. L’Église compte de nos jours plus de 4000 pasteurs, mais vit un conflit de leadership. La cause de ce conflit est la difficulté à reconnaître la place et le rôle du diacre. Le ministère du diacre étant reconnu ou du moins ayant des traces dans l’Église apostolique, il est une nécessité pour nous de réorienter nos réflexions sur la situation actuelle à la lumière des Écritures saintes. En d’autres termes, cette étude vise à comprendre la pratique de ce ministère dans l’Église des Assemblées de Dieu du Burkina Faso, et à apporter une explication théologique basée sur l’expérience de l’Église primitive en se référant à Ac 6,1- 7. Notre démarche se réclame d’une double méthode. La première, dénommée exégèse biblique, avec une approche historique et critique, a permis de comprendre la portée historique de notre corpus en lien avec la pratique du diaconat dans l’Église primitive. La deuxième méthode, dite empirique, a permis d’avoir une compréhension de ce ministère dans l’Église des Assemblées de Dieu du Burkina Faso. Pour cette deuxième méthode, les données recueillies sur le terrain ont permis d’évaluer la perception des acteurs plutôt que de se borner sur nos présuppositions. De ces résultats empiriques, on a pu établir une mise en dialogue qui a généré d’une part des points de consensus et d’autre part des points de divergences. La thèse se termine par la compilation des résultats de nos deux méthodes qui a servi pour faire une interprétation théologique et proposer des perspectives afin d’améliorer le ministère du diacre au profit des églises locales des Assemblées de Dieu du Burkina Faso du XXIe siècle. L’interprétation théologique de ces résultats a aussi contribué à diagnostiquer l’emprise de la culture traditionnelle du Burkina Faso dans le fonctionnement vital des églises. Cette étude qui a un fondement biblique présente le diaconat comme un ministère compréhensible, dynamique, et créatif."
"The ministry of the deacon has occupied an integral place since the origins of the Church of the Assemblies of God of Burkina Faso until today (1921-2017). When the American missionary criss-crossed the land for the proclamation of the Gospel, once he registered a solid nucleus of Christians in the square, he established a deacon to whom he gave the prerogatives of pastors, for they were made rare. We can affirm that in addition to the Holy Spirit's work, the foundation of the Church of the Assemblies of God in Burkina Faso is based on the life, property and skills of many of our patriarchs who deacon. The Church today has more than 4,000 pastors, but lives a conflict of leadership. The cause of this conflict is the difficulty in recognizing the place and role of the deacon. The ministry of the deacon being recognized or at least having traces in the apostolic church, it is a necessity for us to reorient our reflections on the present situation in the light of the Holy Scriptures. In other words, this study aims to understand the practice of this ministry of the diaconate in the Church of the Assemblies of God, and to bring a theological explanation based on the experience of the early Church by referring to the Acts of the Apostles 6,1-7. Our approach calls for a double method. The first known as biblical exegesis served to understand the practice of diaconate in the early Church. The second so-called empirical method allowed us to have an understanding of this ministry in the Church of the Assemblies of God of Burkina Faso. For this second method, the data collected in the field allowed to evaluate the perception of the actors rather than to limit ourselves to our presuppositions. From these empirical results, we have been able to establish a dialogue, which has generated points of consensus on the one hand and points of divergence on the other. The thesis ends with the compilation of the results of our two methods which served to make a theological interpretation and propose perspectives in order to improve the ministry of the deacon in favor of the local churches of the Assemblies of God of Burkina Faso. The theological interpretation of these results has also made it possible to diagnose the hold of traditional Burkina culture in the functionally vital churches. This study, we dare to believe that it presents the ministry of the deacon in the most biblically understandable, dynamic and creative way."

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42

KAVERI, SRINIVAS-VENKATESH. "Etude immunologique des recepteurs beta-adrenergiques." Paris 7, 1987. http://www.theses.fr/1987PA077217.

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Caracterisation des recepteurs beta -adrenergiques humains a ete realisee par des methodes immunologiques (anticorps polyclonaux et anticorps monoclonaux ont ete developpes. Un anticorps anticodytypique ab2b4 reconnait egalement le recepteur beta -adrenergique et stimule l'activite de l'adenylate cyclase comme des ligands agonistes. Au cours de certaines maladies autoimmunes, l'existence d'autoanticorps diriges contre les recepteurs beta -adrenergiques ont ete detectes dans le serum de patients atteints de la maladie de chagas. Le developpement des groupes d'anticorps anti-recepteur obtenus permettront une etude structurale et fonctionnelle du systeme beta-adrenergique

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43

Jebbari, Saïda. "Contribution à l'étude structurale des halogénures de plomb par diffraction des rayons X. Système PBCL::(2X)BR::(2(1-X)) : Comportement de la structure de PBCL::(2) en fonction de la température." Nancy 1, 1988. http://www.theses.fr/1988NAN10159.

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Évolution des paramètres de maille du système PBCL::(2X)BR::(2(1-X)) en fonction de X et apport d'une preuve irréfutable de l'existence d'une substitution ordonnée au niveau des sites halogènes X et Y. Étude de l'enthalpie et de l'entropie de fusion des solutions solides PBCL::(2X)BR::(2(1-X)) en fonction de X. Amélioration de la structure de PBCL::(2) à la température ordinaire, et comparaison avec la structure à T = 473K, 523K ET 573K. Étude de la densité électronique résiduelle par le modèle de vibrations anharmoniques de Gram. Charlier jusqu'à l'ordre 6 A T = 293K et T = 473K

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44

Persson, Josefin, and Jesper Adolfsson. "’’Asså jag tycker ju det är bra att vi har skyldighet att anmäla, för det borde egentligen vara lag någonstans!’’ : -En kvalitativ studie om hur yrkesverksamma inom skolan förhåller sig till sitt ansvar och skyldighet gällande anmälningsskyldigheten i 14 kap 1 § SoL." Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-45556.

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45

Grönström, Alfons. ""Thank you, brother Xi" : En studie i hur Kinas Belt and Road Initiative påverkar EU:s möjlighet att tillämpa sin utvidgningsstrategi." Thesis, Uppsala universitet, Statsvetenskapliga institutionen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418161.

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46

Henderson, Angus Scott. "Recruitment of HMG I and BRG-1 to the activated HIV-1 viral promoter." Phd thesis, 2002. http://hdl.handle.net/1885/146201.

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47

Ho, Wen-Jin, and 何文晉. "Exosomal miR-155 from MSCs promotes AT/RT tumor migration via inhibiting BRG-1." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/87qzvr.

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碩士
國立陽明大學
解剖學及細胞生物學研究所
105
Atypical teratoid / rhabdoid tumor (AT / RT) is a very uncommon tumor type usually diagnosed in older age like childhood. AT / RT can be found on other parts of the central nervous system (CNS), including distant part like spinal cord, surgery with radiant therapy is a classical method for treatment. To investigate AT / RT treatment, decreasing tumor cell migration and invasion can improve the efficiency of surgical treatment. Previous studies show a chromatin re-modeling protein called BRG-1, its expression is absent in AT / RT. Mesenchyme stem cell (MSCs) is normally appear at tumor lesion, it regulates tumor migration, proliferation, and invasion. MSCs can release a type of signal vehicle called exosome, it targets to tumor cell. Ours finding shows that mir-155 is a major microRNA type in MSCs exosome, and it inhibits AT / RT BRG-1 expression. The BRG-1 repression results tumor cell migration. In ours finding, MSCs is major type of mesenchymal stromal cells, it plays a pivot role in AT / RT tumor cell migration, through MSCs miR-155 delivery in exosome. Reducing the MSCs exosome uptake or MSCs miR-155 production, it can rescue the AT / RT BRG-1 expression and decrease cell migration. Also, disable the function of AT / RT endogenous miR-155 can result in tumor cell migration decreasing.

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48

Cheng, Fang-Ju, and 鄭方茹. "Effect of docosahexaenoic acid on EGF-induced urokinase plasminogen activator and matrix metalloproteinase-1/-9 expression in SK-BR3 human breast cancer cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/19469502735580997495.

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碩士
中山醫學大學
營養學研究所
101
Breast cancer is the most commonly diagnosed cancer among women all over the world. Metastasis is the leading cause of death from breast cancer. EGFR and ErbB2 are an important oncogene overexpressed in about 20~30% of breast cancers, and was associated with poor patient outcome and distant metastasis. Previous study showed the induction of urokinase plasminogen activator (uPA) and matrix metalloproteinase (MMP)-1 and MMP-9 activity and expression were associated with breast cancer metastasis. EGF up-regulated uPA, MMP-1, MMP-9 expression by activating EGFR/ErbB2 in ErbB2-overexpressing SK-BR3 breast cancer cells. Diets consisting mostly of docosahexaenoic acid (DHA) have shown to reduce breast cancer incidence rate and have better outcomes There have been several studies on the role of DHA in suppressing breast cancer metastasis,however, the mechanism for the down-regulation of SK-BR3 breast cancer metastasis by DHA is not fully clarified. In the present study, we used ErbB2-overexpression SK-BR3 breast cancer cells to study the effect of DHA on EGF-induced EGFR/ErbB2 expression and activation, and further to investigate whether their downstream signaling pathways are involved in DHA''s down-regulation of EGF-induced MMP-1/-9 and uPA expression in SK-BR3 human breast cancer cells. We found that EGF (40 ng/ml) induced MMP-1, MMP-9, and uPA mRNA, protein expression and enzyme activity in both dose- and time-dependent manners, and 100 μM DHA significantly inhibited the induction of EGF. DHA was shown to inhibit EGF-induced activation of ERK1/2, JNK and Akt (Ser473). AG1478, a tyrosine kinase inhibitor of the EGFR, attenuated ERK1/2, JNK and Akt (Ser473) activation as well. The phosphorylation of EGFR and ErbB2 was induced within 15 min after EGF treatment and the total amount of protein was found to increase after 12 h of EGF exposure and these induction were decreased by DHA. Immuno-fluorescence assay and co-immuno-precipitation analysis showed DHA decreases EGFR expression and intracellular localization in the presence of EGF as well as the interaction between EGFR and ErbB2 was disrupted by DHA. These results suggest that attenuation of EGFR and ErbB2 expression and disruption of protein interaction between EGFR and ErbB2 and EGFR-dependent signaling pathways (ERK1/2、JNK、Akt (Ser473)) are involved in DHA''s down-regulation of EGF-induced MMP-1/-9 and uPA expression in SK-BR3 human breast cancer cells.

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49

Torti, Dax. "Functional Roles of the SWI/SNF ATPase Brahma Related Gene 1 (BRG1) and Special AT-Rich Binding Protein (SATB1) in Virus Response and Innate Immunity." Thesis, 2012. http://hdl.handle.net/1807/32831.

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The innate immune response is a primary transcriptional defence network activated by interferons (IFNs) α/ β in response to viral infection. A cell must have the capability to detect the virus, activate signalling cascades, and engage transcriptional anti-viral networks. IFNs trigger the Signal Transducer and Activator of Transcription (STAT) family, which in turn induce anti-viral gene expression. Recruitment of STATs to IFN stimulated gene (ISG) promoters and the ensuing gene induction requires Brahma Related Gene 1 (BRG1), the catalytic component of the SWI/ SNF chromatin remodelling (or BAF) complex. Cell lines with high BRG1 expression are hyper-responsive to IFN induced transcription, conversely BRG1 low cells exhibit impaired induction. However, BRG1 high cells that are resistant to Encephalomyocarditis virus infection did not require signalling through the IFN receptor complex for anti-viral immunity. This suggested 2F-BRG1 cells must rely on BRG1 dependent non-ISGs or an as yet uncharacterized subset of basally expressed BRG1-dependent ISGs that do not require IFN enhanced expression for anti-viral activity. Utilizing genome wide microarrays we identified five genes with potent anti-viral activity. These genes may restrict viral infection through alterations in integrin signalling, endosomal trafficking, and activation of host transcriptional responses. We also investigated the role of Special AT-Rich Binding Protein (SATB1) in regulation of IFN responsive genes. The loss of this chromatin binding protein is associated with transcriptional changes in the MHC locus that mimic IFNγ induced expression. Through microarray analysis we discovered a remarkable 47% of IFNα regulated genes were co-regulated by SATB1; 42% of IFNα induced genes were induced by SATB1 knock down, while 63% of IFNα repressed genes were SATB1 dependent. Functionally, knock down of SATB1 protected cells from EMCV induced cell death at low multiplicity of infection (MOI), and increased the cytoprotective effect of IFNα against EMCV at higher MOIs. Analysis of IFNα, SATB1 and BRG1 regulated genes revealed a subset of core genes regulated by all three factors that may be critical to robust anti-viral immunity. The potent immunosuppressive properties of SATB1 suggest this protein may be involved in complex immunopathologies. The immuno-modulatory properties of SATB1 and BRG1 established in this thesis provide substantive evidence for the development of pharmaceutical therapies targeting these proteins.

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50

Huang, Chien Chih, and 黃建誌. "1.Decomposition Reaction of Pd(CH=CHR)(Br)(PPh3)2;2.Oxidative Ad- dition of Tetraaryl Phosphonium Salt to Pd(0)." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/72063703511091146830.

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碩士
國立清華大學
化學學系
82
PdI(Ar)(PPh3)2的苯環交換反應,在一般的有機溶劑中都會發生.那如果Ar 取代基換為烯基時,是否會有同樣的情況發生呢?當我們把PdBr(CH=CH )(PPh3)2溶在CDCl3作交換反應追蹤時,卻得到化合物Pd(0)-olefin com- ,結構鑑定是利用單晶X-ray繞射方法.一般Pd(0)-olefin complex 不b ,這是因為Pd的游離能較高,回饋鍵較弱.鹵化烯基三苯基鏻在常溫下與Pd( PPh3)4反應可得Pd(0)-olefin com- plex.在溶劑為THF,溫度為攝氏60度, 卻會有氧化還原加成反應的發生.以其整個步驟來看,這似乎是達成烯基苯環交換反應的分解步驟.第一步驟先形成鏻鹽,第二步驟再氧化加成至Pd金屬中心.我做了一些四芳香基鏻鹽氧化加成至Pd上,嘗試著解釋苯環交換的反應可能途徑.我們提出二可能性的反應途徑來解釋PdI(Ar)(PPh3)2的苯環交換反應。途徑一：PdI(Ar)(PPh3)2在溶劑中及PPh3存在下產生 tetraaryl phosph- onium salt及Pd(PPh3)2，但是四芳香基鏻鹽似乎沒有離開Pd的配位圈，馬W又氧化加成回去，得到苯環交換反應的產物，如果碘化四芳香基鏻有離開開Pd金屬的配位圈，便會在溶液中沈澱出來，便較不容易再氧化加成回去了。途徑二：PdI(Ar)(PPh3)2在溶劑中先有一分子的PPh3游離出來，產生中間體，而後經由一個分子內的重排反應使的芳香基轉移到磷上，苯環轉移到Pd上，再與一分子的PPh3重新結合完成交換反應。

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Dissertations / Theses on the topic 'Brg-1'

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