Dissertations / Theses on the topic 'BRET'
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Eustace, Natalie Margaret. "Biological Realistic Education Technology (BRET)." Thesis, University of Canterbury. HIT Lab NZ, 2014. http://hdl.handle.net/10092/9242.
Full textBorghei, Golnaz. "Design of a BRET fluorescent protein." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607666.
Full textYoung, Joshua B. "Bret & Vince Get Framed for Murder." Ohio University Honors Tutorial College / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1339258933.
Full textWeissenberg, Clare. "This is not an exit : reading Bret Easton Ellis." Thesis, University of Essex, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361020.
Full textNystrand, Alexander. "Patrick Bateman, Violence and Consumption: Bret Easton Ellis’s American Psycho." Thesis, Södertörns högskola, Institutionen för kultur och kommunikation, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-7875.
Full textSilva, Luciano Cabral da. "The fourfold serial killer in Bret Easton Elliss American Psycho." Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8749.
Full textPatrick Bateman, o protagonista narrador do romance American Psycho (1991), de Bret Easton Ellis, confunde por ser rico, bonito e educado e, ao mesmo tempo, torturador, assassino e canibal. Mas esta personalidade antagônica não o torna singular. O que o particulariza são as quatro faces que ele apresenta ao longo de sua narrativa: (1) ele consome mercadorias e humanos, (2) compete para ter reconhecimento, (3) provoca horror por suas ações, e (4) não é um narrador confiável. Sendo um yuppie (termo popular usado nos Estados Unidos na década de 1980 para denominar jovens e bem sucedidos profissionais urbanos), Bateman é materialista e hedonista. Ele está imerso em uma sociedade de consumo, fato que o impossibilita de perceber diferenças entre produtos e pessoas. Sendo um narcisista, ele se torna um competidor em busca de admiração. No entanto, Bateman também é um serial killer e suas descrições detalhadas de torturas e assassinatos horrorizam. Por fim, nós leitores duvidamos de sua narrativa ao notarmos inconsistências e ambiguidades. Zygmunt Bauman (2009) afirma que uma sociedade extremamente capitalista transforma tudo que nela existe em algo consumível. Christopher Lasch (1991) afirma que o lendário Narciso deu lugar a um novo, controverso, dependente e menos confiante. A maioria das vítimas de Bateman são membros de grupos socialmente marginalizados, como mendigos, homossexuais, imigrantes e prostitutas, o que o torna uma identidade predatória, segundo Arjun Appadurai (2006). A voz autodiegética e a narrativa incongruente do protagonista, contudo, impedem que confiemos em suas palavras. Estas são as quatro faces que pretendo apresentar deste serial killer
The autodiegetic protagonist Patrick Bateman, in Bret Easton Elliss American Psycho (1991), is a troubling character, for he is highly-educated, wealthy and handsome as well as a torturer, a killer and a cannibal. This antagonistic behavior, nonetheless, does not make him a singular character. The four sides he presents throughout the novel are singular, though: (1) he consumes humans and commodities equally; (2) he competes for recognition and admiration; (3) his acts are horrific; and (4) his narration is unreliable. As a yuppie (a popular term from the 1980s used to define young urban U.S. professionals), Bateman is materialistic and hedonistic. As he lives off the excesses of a consumer society, he is incapable of distinguishing people from products. As a self-absorbed, narcissistic protagonist, he becomes a competitor struggling to get approval from his peers. Nevertheless, Bateman is a serial killer, and his detailed descriptions of tortures and murders are horrifying. Finally, we readers cannot rely on his narrative once we notice ambiguities and divergences. Zygmunt Bauman (2009) posits that an extremely capitalist society forces people to be commodified. Christopher Lasch (1991) asseverates that the old legendary Narcissus gave birth to a new one, paradoxical, dependent and less confident. Most of Batemans victims are socially-marginalized characters, members of minority groups, such as homeless people, homosexuals, immigrants, and prostitutes. As a matter of fact, Bateman may be regarded as having a predatory identity, as defined by Arjun Appadurai (2006). However, this autodiegetic narrator, together with his inconsistent narrative, cannot be entirely trusted. These are the points I want to debate regarding this fourfold serial killer
Helm, Kimberly Anne. "Is everything disposable? Bret Easton Ellis, abortion, and consumer culture." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004643.
Full textIssafras, Hassan. "Étude de l'oligomérisation du récepteur CCR5 par la technique de BRET." Paris 7, 2002. http://www.theses.fr/2002PA077211.
Full textLacaze, Annie. "Hysteroplastie selon Bret-Palmer : à propos de 43 cas d'utérus cloisonnés." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR1M059.
Full textArmando, Sylvain. "Structure quaternaire des récepteurs de chimiokines CXCR4 et CCR2 et interaction avec leur effecteurs." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20208/document.
Full textG protein coupled receptors (GPCR) are the most represented cell surface receptors among vertebrates, and the major therapeutic target in humans. The initial paradigm stating a 1 :1 :1 stoichiometry for receptor :G protein :effector has evolved to a more complex model, as illustrated here with the example of the chemokine receptors CXCR4 and CCR2. Bioluminescence resonance energy transfer (BRET) was used to demonstrate that (1) CXCR4 is able to couple Gα13 instead of Gαi to promote breast cancer metastasis, (2) the multiple pathways engaged by stimulation of CXCR4 are selectively desensitized by the specific recruitment of a defined combination of proteins (GRKs and arrestins) and (3) the CXCR4 protomer plays a crucial role during Gαi engagement and β-arrestin recruitment by the CXCR4/CCR2 heterodimer upon CCR2 activation. In this last and main study, the results shown also demonstrate that CCR2 dimers could assemble with CX CR4 dimers into hetero-tetramers, and that CCR2 activation leads to a conformational change in the CXCR4 dimer. Former results showing cooperativity and asymmetric activation of a simple CXCR4/CCR2 heterodimer could then be applied to a tetramer. To conclude, the work done during this thesis demonstrates a more sophisticated regulation of chemokine receptors than previously suspected at 3 different levels: quaternary structure of the protomers, G protein signalling, and signalling termination
von, Seth Oscar. "Psykopaten i garderoben : En queer läsning av Bret Easton Ellis American Psycho." Thesis, Södertörns högskola, Institutionen för kultur och lärande, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-21456.
Full textRomanen American Psycho publicerades 1991. Den fick hård kritik och sågs som ett heterosexistiskt, misogynt verk fullt av meningslöst våld. Trots kritiken fascinerade protagonisten, den förmögna seriemördaryuppien Patrick Bateman, läsarna. Bateman döljer sin monstrositet bakom en heteronormativ fasad men den här uppsatsen visar att textens heteronorm är bräcklig. Batemans relationer är ytliga, identiteten är konstruerad från traditionella maskulinitetsnormer, han är homofobisk, även då gotiska, homoerotiska undertoner präglar texten. Analysen visar att AIDS-skräcken som präglar boken är synonym med Batemans sexualitetsdiskrepans, att hans känslor för två av hans kollegor är av homoerotisk karaktär, samt att i ytliga läsningar av romanen, där texten inte tolkas, gör det explicita våldet att läsarens uppmärksamhet avleds från romanens queera innebörd.
Mortimer, Danielle. "Traumatic seductions : Bret Easton Ellis's Lunar park, the postmodern, and the reader." Thesis, University of Essex, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549291.
Full textRHONE, GERARD PASCALE. "Resultats obstetricaux apres intervention de bret-palmer : a propos de 27 observations." Reims, 1988. http://www.theses.fr/1988REIMM033.
Full textOnfroy, Lauriane. "Développement de biosenseurs BRET prédictifs de la cardiotoxicité des médicaments anti-tumoraux." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30071/document.
Full textCardiotoxicity is a recognized long-term consequence of a lot of anticancer drugs, but its mechanisms are not well-known. To date, the cardiotoxic potential of anticancer drugs is difficult to predict during preclinical studies due to the lack of appropriate tools. In this context, the aim of this thesis project was to develop biosensors, based on the use of bioluminescent resonance energy transfer (BRET) principle, to measure class IB phosphoinositide-3-kinases (PI3K) activity. Indeed, these ubiquitous kinases are major pharmacological oncotargets due to their participation in cancer development, but they also have a preponderant role in cardiac homeostasis. Thus, they could represent cardiac targets for anticancer drugs participating in the development of cardiotoxicity.PI3K-IB are heterodimers of a catalytic subunit (C) p110y and a regulatory subunit (R) p87 or p101. To develop the PI3Ky sensor, BRET energy donor (Rluc8) and acceptor (GFP2) were fused at the N-terminal or C-terminal of each subunit (intermolecular sensor). After expression control of each probe in HEK293T cells, the interactions between C and R subunits for all BRET pairs (8 combinations) were studied, in living cells in real time, so to find one able to sense PI3Ky activation. Our results indicated specific basal interaction between C and R subunits from p110y-p87 and p110y-p101 pairs. However, none of the stimulation conditions tested (receptor nature, ligand concentration, stimulation kinetics and biosensor stoichiometry) allowed the detection of BRET signal modulation. Further addition of p110y co-activators such as Ras proteins or heterotrimeric G proteins, did not improve BRET modulation. We then tried to create an indirect BRET sensor of PI3Ky activity by measuring the interaction between PI3K and G proteins subunits, known to occur during PI3Ky activation. Surprisingly, results highlighted a basal pre-association of PI3Ky and G protein subunits without BRET modulations upon PI3Ky stimulation.In conclusion, we failed to create a BRET biosensor of the PI3Ky activity based on the measure of the interaction between the catalytic and regulatory subunits. However, the pre-association of PI3K subunits without BRET modulation could reflect a mechanism of PI3Ky activation based on conformationals changes of the complex between C and R subunits rather than physical association-dissociation. In the future, intramolecular labeling of the C or R subunit with the two BRET probes could better detect conformational changes and therefore PI3Ky activity. From a fundamental standpoint, the existence of PI3Ky-G proteins pre-complexes could reflect a specific spatio-temporal fine-tuning of the PI3K activity, in agreement with recent concept of preformed cell signaling platforms
Roche, David. "L'imagination malsaine : Russell Banks, Raymond Carver, David Cronenberg, Bret Easton Ellis, David Lynch /." Paris : l'Harmattan, 2008. http://catalogue.bnf.fr/ark:/12148/cb412407868.
Full textZhou, Yi Yuan. "Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19761.
Full textEttler, Justine. "The Best Ellis For Business: A Re-Examination Of The Mass Media Feminist Critique Of American Psycho." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10020.
Full textLundberg, Robin. "Unreliable narration in Bret Easton Ellis's American Psycho and Jeff Lindsay's Darkly Dreaming Dexter." Thesis, Karlstads universitet, Institutionen för språk, litteratur och interkultur, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-34929.
Full textDenna uppsats fokuserar på karaktären Patrick Bateman i American Psycho skriven av Bret Easton Ellis, med tanke på denna karaktärs opålitlighet som berättare. Detta jämförs med karaktären Dexter Morgan från Darkly Dreaming Dexter skriven av Jeff Lindsay och denna karaktärs opålitlighet som berättare. Detta opålitliga berättande analyseras utifrån en modell som består av sex kategorier vilka James Phelan och Mary Patricia Martin har formulerat. Dessa kategorier kallas: ”misreporting”, ”misreading”, ”misregarding”, ”underreporting”, ”underreading” och ”underregarding”. Resultatet av analysen visar på att Patricks berättande kan placeras in i fyra av dessa kategorier (”misreporting”, ”misreading”, ”misregarding” och ”underreading”). Detta i jämförelse med Dexters berättande som kan placeras in i tre av dem (”misreading”, ”underreading” och ”underregarding”). Även fast denna skillnad kan verka obetydlig är det ändå så att de exampel på opålitlighet som Patrick visar upp står att finna i fler och tydligare exempel än hos Dexter vilket innebär att Patrick kan ses som en mer opålitlig berättare än Dexter. Resultatet av analysen indikerar att olika karaktärers berättande kan återfinnas i olika ändar av ett opålitlighetsspektrum. På detta spektrum kan Patrick då placeras in som en mer opålitlig berättare än Dexter som hamnar i den mer pålitliga delen av spektrumet.
Andersson, Jim. "Psykopatfabriken : Maskulinitetskonstruktioner i Iain Banks The Wasp Factory och Bret Easton Ellis American Psycho." Thesis, Uppsala universitet, Litteraturvetenskapliga institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302290.
Full textRuigrok, Hermanus. "Étude en temps réel des effets cellulaires et moléculaires des champs électromagnétiques radiofréquence environnementaux." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0674/document.
Full textThe biological and health effects of radiofrequency (RF) electromagnetic fields (EMF) exposure have been very actively studied in the past two decades, mainly triggered by concerns about potential health effects of wireless communication systems. This physical agent is among the most common, fastest-growing environmental factors, triggering concerns in the population, as even a minor effect of EMF exposure on health could have a major public health impact. While the effects of extremely low frequency electromagnetic fields (ELF EMF) on the excitation of nerve and muscle cells have been well-characterized, the only well-described effects of radiofrequency electromagnetic fields (RF EMF) on biological systems are caused by dielectric-relaxation heating. In contrast, “nonthermal” RF EMF effects refer to other potential biological effects that are not caused by temperature elevation of living tissue or cell culture medium. The investigation of such mechanisms has been hampered by the absence of robust, reliable and repeatable effects occurring as a consequence of low-level exposures, for which temperature elevation is minimal. Moreover, no plausible mechanistic hypotheses have been given concerning thermal or nonthermal effects of low-level RF EMF exposures, making difficult to draw conclusions on the basis of available experimental results. Nonetheless, in 2011, the International Agency for Research on Cancer (IARC) classified RF emitted by cell phones as “possibly carcinogenic to humans” (Class 2B). The characterization of nonthermal biological RF EMF effects is therefore of primary importance for setting safety limits since guidelines and standards have so far been set to protect from the known health risks associated only with the thermal effects of RF EMF exposures. The aim of this basic science thesis work is to characterize the effects of environmental RF EMF signals on living matter at the cellular and molecular level. In this work, we took advantage of modern and innovative methods to observe the behavior of living matter under RF EMF exposure in real time at various specific absorption rates (SAR). In particular, we have studied: (i) Specific RF EMF effects on the ionic channel TRPV1, a major thermoreceptor in our body. TRPV1 activation under RF EMF exposure was studied using the bioluminescence resonance energy transfer (BRET) technique. The implementation of this technique called for the construction and characterization of BRET probes targeting TRP channels as well as the development of a device for the remote measurement of BRET spectra, using an optical fiber. The conclusion of this part of the thesis is that RFs are able to activate the TRPV1 channel by producing a dielectric heating but in the absence of temperature increase there is no RF effect on the basal activation state of TRPV1 and no change of capsaicin maximal efficacy to activate TRPV1. (ii) The analysis of the global behavior of cells in culture under RF exposure was carried out using a modified xCELLigence system where the array of electrodes of the measuring plates were also used to expose the cells to RF EMF. Using this device, we were able to perform SH-SY5Y cell exposures with a SAR of 24 W/kg without causing heating in the culture medium or in the cell culture. No effect of RF EMF on the behavior of the neuroblastoma SH-SY5Y line could however be demonstrated, either in the absence or in the presence of a co-stimulation by a chemical agent. The conclusion of this study is that under conditions where the temperature remains stable, we have not been able to demonstrate any changes in the functioning of living cells, ether at the molecular level or at the cellular level. The tools developed in this thesis work offer important prospects both in the field of drug screening using spectral BRET, and pave the ways for future studies in bioelectromagnetics
Alt, Constanze. "Zeitdiagnosen im Roman der Gegenwart Bret Easton Ellis' American Psycho, Michel Houellebecqs Elementarteilchen und die deutsche Gegenwartsliteratur." Berlin Trafo, 2009. http://d-nb.info/992353327/04.
Full textWeibels-Balthaus, Gregor. "The self in trouble: young adults in the urban consumer society of the 1980s in Janowitz, Ellis, and McInerney." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976449706.
Full textPerzo, Nicolas. "Rôle des déterminants moléculaires impliqués dans la signalisation du récepteur urotensine II." Mémoire, Université de Sherbrooke, 2013. http://hdl.handle.net/11143/6349.
Full textNabo, João Luís Brejo. "O escritor e o seu duplo em Bret Easton Ellis: uma contribuição para a análise do processo de auto-referencialidade no gótico norte-americano contemporâneo." Master's thesis, Universidade de Évora, 2008. http://hdl.handle.net/10174/18409.
Full textGoyet, Elise. "Dynamique et fonction des interactions entre récepteurs du glutamate et de la dopamine." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT019.
Full textIn some specific brain areas, synergism between glutamate and dopamine transmission is required to induce synaptic plasticity. Metabotropic glutamate receptor mGlu5 and dopamine receptor D1 are both known to control synaptic plasticity. Moreover, multiple lines of evidence converge toward the ability of G-protein coupled receptors to form dynamic heteromers thereby creating new entities with unique properties. Focusing on the hypothesis of receptor heteromerization, my PhD project aimed at investigating the molecular mechanisms underlying a functional interplay between mGlu5 and D1 receptors.To address this issue, a first part of this work consisted in improving single-cell Bioluminescent Resonance Energy Transfer (BRET) imaging, a technology enabling to study real time protein-protein interaction dynamics in living cells. Using the Nanoluciferase, an extremely bright luciferase, we characterized a faster and higher resolution single-cell BRET imaging technique with unprecedented performance in terms of temporal and spatial resolution, duration of signal stability and signal sensitivity. In the second part of this project, we showed that mGlu5 and D1 can form heteromers in heterologous expression system. The above-mentioned improvements of single-cell BRET imaging technique allowed to evidence the occurrence and the dynamics of mGlu5/D1 heteromers in cultured primary neurons. Furthermore, our results showed that the co-expression of mGlu5 and D1 receptors modifies single receptor properties to favor calcium signaling by increasing mGlu5 constitutive activity and creating a D1 agonist-induced activation of Ca2+ release from intracellular stores.These findings advance our knowledge about the molecular basis of the glutamate/dopamine functional dialogue to control neuronal communication in physiological conditions. Further investigation will help the dissection of the mGlu5/D1 heteromer specific signaling pathway with the hope of defining new therapeutics that may selectively modulate heteromer function and thus bypass undesirable side effects
Bengtsson, Tomas. "Självframställningens dilemma : En biografisk och tematisk undersökning av självframställningen i Bret Easton Ellis roman Lunar Park." Thesis, Uppsala universitet, Litteraturvetenskapliga institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-191833.
Full textAnnesley, James. "Blank fiction : culture, consumption and the contemporary American novel." Thesis, University of Sussex, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321347.
Full textBusonik, Stephen. "Epistemic structuralism in the postmodern novel : the examples of William Gaddis, J.G. Ballard, and Bret Easton Ellis /." Connect to resource, 1993. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1260971951.
Full textFERRARI, Federica. "Pharmacological profile of nociceptin/orphanin FQ receptor – characterization of novel peptide and non peptide ligands." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2478798.
Full textNociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of the N/OFQ peptide receptor (NOP) and this peptidergic system controls several biological functions in the central nervous system as well as in the periphery. The aim of the present study was the pharmacological characterization of novel peptide and non-peptide NOP ligands. A series of N/OFQ dimeric compounds and the antagonist PWT2-UFP-101 were designed and synthesized in our University while non-peptide NOP ligands were from pharmaceutical companies. All compounds were evaluated in vitro in several assays including receptor binding, stimulated GTPγ[35S] binding, calcium mobilization studies performed in cells co-expressing the human recombinant receptors and chimeric G-proteins, bioluminescence resonance energy transfer (BRET) experiments investigating receptor interaction with G protein and β-arrestin 2, and bioassay studies in isolated tissues. A series of dimeric NOP ligands with spacers of different lengths were generated using as peptide pharmacophore N/OFQ(1-13)NH2 and were pharmacologically investigated in a calcium mobilization assay and in the mouse vas deferens bioassay (mVD). Results demonstrated that dimerization did not modify the pharmacological activity of peptide pharmacophore. Moreover, when dimeric compounds were generated with short peptide pharmacophores, dimerization recovered ligand potency. This effect depends on the doubling of the C terminal address sequence in the dimeric ligand. The novel peptide antagonist PWT2-UFP-101 has been evaluated in vitro in a BRET based assay measuring NOP/G protein interaction and in mVD. The molecule maintains the antagonist activity, competitive behavior, and potency of the linear peptide. In vivo, PWT2-UFP-101 has been tested in mice in the forced swimming test where was able to elicit the same antidepressant like effects of UFP-101, being 10 fold more potent. However, PWT2-UFP-101, inhibited spontaneous locomotor activity. The non-peptide NOP agonists Ro 65-6570, Ro 2q, SCH-221510, MCOPPB, AT-403, AT-202 and SCH-486757 have been pharmacologically characterized and compared. All compounds behaved as full NOP agonists consistently showing the following rank order of potency MCOPPB>AT-403>Ro 65-6570=Ro 2q>SCH-221510>AT-202>SCH-486757. Moreover, all molecules displayed some degree of G protein biased agonism with the exception of AT-403 that behaved as an unbiased agonist. MCOPPB and AT-403 displayed the highest potency associated to the highest selectivity both at human and murine NOP receptors. A series of five AT non-peptide NOP partial agonists were also characterized. AT compounds displayed high NOP affinity and behaved as NOP agonists in all the functional assays consistently showing the following rank order of potency AT-127>AT-090>AT-035>AT-004=AT-001. AT compounds behaved as NOP full agonists in the calcium mobilization and mouse colon assays and as partial agonists in the GTPγ[35S] and BRET assays. Interestingly AT-090 and AT-127, behaved as an unbiased agonists and displayed higher NOP selectivity than Ro 65-6570 at native mouse receptors. Finally, the non-peptide antagonist AT-076 was pharmacologically characterized in vitro at NOP and opioid receptors in the calcium mobilization assay and in the electrically stimulated mouse vas deferens and guinea pig ileum. At human recombinant receptors, AT-076 acts as antagonist with the following rank order of potency: kappa>>mu>>delta=NOP. The moderate potency of AT-076 at mu receptor and its very low potency at NOP and delta receptor has been confirmed in bioassay studies. These results suggest that AT-076 should be classified as a rather selective kappa antagonist. In conclusion, the present thesis investigated in great detail the pharmacological profile of several peptide and non-peptide ligands for the NOP receptor, thus providing to the scientific community novel tools useful for investigating the therapeutic potential of the NOP receptor.
Hardie, Michael L. "Using Hamlet and Peter Pan: Family Issues, Ghosts, and Memory in Bret Easton Ellis's Lunar Park." ScholarWorks@UNO, 2016. http://scholarworks.uno.edu/td/2233.
Full textDarbandi-Tehrani, Kévin. "Etude de la structure du CX3CR1 par BRET : effet anti-tumoral de son ligand, le CX3CL1." Paris 6, 2010. http://www.theses.fr/2010PA066396.
Full textLangenbruch, Lisa Marie [Verfasser], and Erhard [Akademischer Betreuer] Wischmeyer. "Biolumineszenz-Resonanz-Energietransfer (BRET) zur Untersuchung der Dimerisierung des Mineralokortikoidrezeptors / Lisa Marie Langenbruch. Betreuer: Erhard Wischmeyer." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1014892201/34.
Full textd'Hont, Coco. "Brutal bodies : exploring transgression through the fiction of Chuck Palahniuk, Poppy Z. Brite, and Bret Easton Ellis." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/59676/.
Full textBusnelli, M. "Development of a BRET-based assay to investigate the multiple G protein coupling of the oxytocin receptor." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/63231.
Full textБойко, М. И. "Физиолого-биохимические особенности системы Pinus Sywestuis. - Heterobasidion annosur (Fr) Bret и перспективы практического использования экзометаболитов некоторых дереворазрушающих грибов." Diss. of Doctor of Biological Sciences, Донецкий гос. унив., 1996.
Find full textBusonik, Stephen. "Epistemic structuralism in the postmodern novel : the examples of William Gaddis, J. G. Ballard, and Bret Easton Ellis." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1260971951.
Full textBusonik, Stephen William. "Epistemic structuralism in the postmodern novel: The examples of William Gaddis, J. G. Ballard, and Bret Easton Ellis /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487847309053231.
Full textAyoub, Mohammed Akli. "Etude de la dimérisation des récepteurs de la mélatonine par la technique de BRET : Bioluminescence Resonance Energy Transfer." Paris 11, 2003. http://www.theses.fr/2003PA11T043.
Full textMarquez, Marcel. "Optimisation de la technique de BRET : étude de l’association des variants d’HMGA1 avec le diabète de type 2." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S035.
Full textThe BRET technique is based on resonance energy transfer has been described by Förster and is based on a luminescentdonor enzyme and a complementary acceptor fluorophore upon oxidation of a donor enzyme substrate. Unlike many techniquesfor the study of protein-protein interactions, the BRET is non-invasive and allows the dynamic study of interaction between twoproteins in living cells and the screening of molecules modulating this interaction.In our study, we sought to optimize the BRET technique for screening assay by selecting the best pair of donor / acceptor.Rluc8, a new donor, with superior light capabilities than Rluc, was tested in combination with two new acceptors, YPET, avariant of YFP optimized for energy transfer, and RGFP, a fluorophore from Renilla reniformis which is involved in theBREAT signal when in contact with Rluc. These new donors / acceptors were compared to the original Rluc / YFP combination,usually used in BRET1, in fusion proteins and in follow-up studies of protein-protein interactions involving GPCRs and βARR2in order to assess their capacity to improve the BRET technique. We were able to show that Rluc8, YPET and RGFP increasedthe sensitivity of the original BRET1 method by increasing at least 2-fold of the BRET signal. These results demonstrate theinterest of these new donors / acceptors in BRET technique and may help improving current follow-up studies of protein-proteininteractions
Fredriksson, Sophia. "Abandon All Hope : An Analysis of American Psycho." Thesis, Högskolan Dalarna, Engelska, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:du-6391.
Full textGondoin, Anaïs. "Etude et développement d’agents insulino-sensibilisateurs inhibant l’interaction IR-Grb14." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T018.
Full textWadström, Simon. "Anteckningar från en skyskrapa : En studie av Fjodor Dostojevskijs Anteckningar från ett källarhål och Bret Easton Ellis American Psycho." Thesis, Uppsala universitet, Litteraturvetenskapliga institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150993.
Full textLutton, Alison Mary. "Authorship and the production of literary value, 1982-2012 : Bret Easton Ellis, Paul Auster, J.T. LeRoy, and Tucker Max." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3aa64675-73a2-42a8-be24-cb75f034e9de.
Full textLeypoldt, Günter. "Casual silences : the poetics of minimal realism from Raymond Carver and the New Yorker School to Bret Easton Ellis /." Trier : Wissenschaftlicher Verlag Trier, 2001. http://catalogue.bnf.fr/ark:/12148/cb388753788.
Full textSimon, Alaina R. "Satire and Sympathy in American Psycho." University of Toledo Honors Theses / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=uthonors1355508133.
Full textFerry, Peter. "Masculinity in Manhattan : reading hegemonic masculinity in selected novels of Paul Auster, Don DeLillo, Bret Easton Ellis and Jed Rubenfeld." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601475.
Full textWagner, Annette. "Postmoderne im Adoleszenzroman der Gegenwart : Studien zu Bret Easton Ellis, Douglas Coupland, Benjamin von Stuckrad-Barre und Alexa Hennig von Lange /." Frankfurt am Main : P. Lang, 2007. http://catalogue.bnf.fr/ark:/12148/cb41147777t.
Full textMacha, Bret B. [Verfasser], Holger [Gutachter] Braunschweig, Todd [Gutachter] Marder, and Matthias [Gutachter] Lehmann. "Boron-Containing Aromatics as Communicating and Communicative Units in π-Conjugated Systems / Bret B. Macha ; Gutachter: Holger Braunschweig, Todd Marder, Matthias Lehmann." Würzburg : Universität Würzburg, 2016. http://d-nb.info/1120924987/34.
Full textHawryluk, Lynda J., University of Western Sydney, of Arts Education and Social Sciences College, and of Communication Design and Media School. "Call waiting." THESIS_CAESS_CDM_Hawryluk_L.xml, 2001. http://handle.uws.edu.au:8081/1959.7/6.
Full textDoctor of Philosophy (PhD)
Wallbanks, Mark. "The vicissitudes of the authentic self: a literary mapping of the authentic self from John Milton's Paradise lost to Bret Easton Ellis' Glamorama /Mark Wallbanks." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/364.
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