Journal articles on the topic 'Breastfeeding Effect of drugs on'
To see the other types of publications on this topic, follow the link: Breastfeeding Effect of drugs on.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Breastfeeding Effect of drugs on.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Ferracini, Amanda, Aline Rodrigues, Marília Visacri, Rebeca Stahlschmidt, Nice Silva, Fernanda Surita, and Priscila Mazzola. "Potential Drug Interactions and Drug Risk during Pregnancy and Breastfeeding: An Observational Study in a Women's Health Intensive Care Unit." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 39, no. 06 (June 2017): 258–64. http://dx.doi.org/10.1055/s-0037-1603680.
Full textAbstract:
Introduction In the pregnancy-puerperal cycle, women may develop complications that require admission to the Intensive Care Unit (ICU). Thus, special attention to pharmacotherapy is necessary, particularly to potential drug interactions (PDIs) and to the effect of the drugs on the fetus and newborn. Objective The aim of this study was to determine the profile of PDIs and the potential risk of drugs used during pregnancy and breastfeeding among patients admitted to the ICU. Methods We conducted an observational, cross-sectional and prospective study, including pregnant and breastfeeding women admitted to the ICU at the Women's Hospital of a university in the city of Campinas, Brazil, for one year. Online databases were used to identify and classify the PDIs and the potential risk of the drugs used during pregnancy and breastfeeding. Results We evaluated 305 prescriptions of 58 women, 31 pregnant and 27 breastfeeding, and 284 (91%) prescriptions presented PDIs. A total of 175 different combinations of PDIs were identified in the prescriptions, and adverse effects caused by the simultaneous use of drugs were not actually observed in the clinical practice. A total of 26 (1.4%) PDIs were classified as contraindicated. We identified 15 (13.8%) drugs prescribed with risk D, and 2 (1.8%) with risk X for pregnant women, as well as 4 (4.9%) drugs prescribed with high risk for breastfeeding women. Conclusions This study demonstrates that there is a high incidence of PDIs in prescriptions. Most drugs used by pregnant and breastfeeding women at the ICU did not present serious risks to their fetus and newborns, but sometimes drugs with risk D or X are necessary in the course of the treatment.
2
Octaviani, Dwi Nur, Sugianto Sugianto, Masmuni Wahda Aisya, and Nurhayati Mahmud. "Influence of Breastfeeding Support Group (KP-ASI) on the success of exclusive breastfeeding in the Molingkapoto Community Health Center." Journal of Midwifery 6, no. 1 (July 7, 2021): 1. http://dx.doi.org/10.25077/jom.6.1.1-7.2021.
Full textAbstract:
Exclusive breastfeeding is giving only breast milk without giving other food and drinks to babies from birth to 6 months of age, except for drugs and vitamins. The purpose of this study was to determine the effect of breastfeeding support groups (KP-ASI) on the success of exclusive breastfeeding. The research method used is quantitative descriptive analytic which is cross sectional. The independent variable is the breastfeeding support group (KP-ASI), while the dependent variable is the success of exclusive breastfeeding. Case samples are mothers who have babies aged 6-24 months. The results of the study were based on the Chi-square statistical test, the results obtained were p = 0.001 (p <0.05), meaning that there was a significant relationship between breastfeeding support groups (KP-ASI) on the success of exclusive breastfeeding. Conclusion Breastfeeding Support Groups (KP-ASI) have a very big influence on the success of exclusive breastfeeding; most of who are assisted makes it to the exclusive breastfeeding stage.
3
Almas, Saneea, Jesse Vance, Teresa Baker, and Thomas Hale. "Management of Multiple Sclerosis in the Breastfeeding Mother." Multiple Sclerosis International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/6527458.
Full textAbstract:
Multiple Sclerosis (MS) is an autoimmune neurological disease characterized by inflammation of the brain and spinal cord. Relapsing-Remitting MS is characterized by acute attacks followed by remission. Treatment is aimed at halting these attacks; therapy may last for months to years. Because MS disproportionately affects females and commonly begins during the childbearing years, clinicians treat pregnant or nursing MS patients. The intent of this review is to perform an in-depth analysis into the safety of drugs used in breastfeeding women with MS. This paper is composed of several drugs used in the treatment of MS and current research regarding their safety in breastfeeding including immunomodulators, immunosuppressants, monoclonal antibodies, corticosteroids, and drugs used for symptomatic treatment. Typically, some medications are large polar molecules which often do not pass into the milk in clinically relevant amounts. For this reason, interferon beta is likely safe for the infant when given to a breastfeeding mother. However, other drugs with particularly dangerous side effects may not be recommended. While treatment options are available and some data from clinical studies does exist, there continues to be a need for investigation and ongoing review of the medications used in breastfeeding mothers.
4
Garry, Aurélia, Virginie Rigourd, Ammar Amirouche, Valérie Fauroux, Sylvie Aubry, and Raphaël Serreau. "Cannabis and Breastfeeding." Journal of Toxicology 2009 (2009): 1–5. http://dx.doi.org/10.1155/2009/596149.
Full textAbstract:
Cannabis is a drug derived from hemp plant,Cannabis sativa, used both as a recreational drug or as medicine. It is a widespread illegal substance, generally smoked for its hallucinogenic properties. Little is known about the adverse effects of postnatal cannabis exposure throw breastfeeding because of a lack of studies in lactating women. The active substance of cannabis is the delta 9 TetraHydroCannabinol (THC). Some studies conclude that it could decrease motor development of the child at one year of age. Therefore, cannabis use and abuse of other drugs like alcohol, tobacco, or cocaine must be contraindicated during breastfeeding. Mothers who use cannabis must stop breastfeeding, or ask for medical assistance to stop cannabis use in order to provide her baby with all the benefits of human milk.
5
Harun, Nurhidayati, Firdawati Firdawati, and Nia Kurniasih. "Safe Medicine Administration Counseling for Pregnant and Breastfeeding Mothers." ABDIMAS: Jurnal Pengabdian Masyarakat 4, no. 2 (January 3, 2022): 1134–39. http://dx.doi.org/10.35568/abdimas.v4i2.1118.
Full textAbstract:
The use of drugs for pregnancy and breastfeeding needs to be self-medication and the importance of counselling to increase the mother's knowledge about the correct use of drugs so that pregnant and lactating women's level of health and knowledge increases. The counselling purpose was to determine the mother's level of knowledge and whether there was a difference in the knowledge level of the use of drugs during pregnancy and lactation. The method used is pre and post-media analysis (flipchart). Data analysis obtain by scoring questionnaires, univariate analysis, and statistical analysis. Mann-Whitney test results showed that in the post-test or after giving counselling using flipchart media, there was a change in respondents' knowledge from before being given a flipchart and after being given a flipchart. The hypothesis from this counselling is accepted, which means that giving flipcharts affects the level of knowledge. The calculations using the spearman test obtained p-value pretest 0.732 and p-value post-test 0.253 for pregnant women and obtained p-value pretest and post-test of 0.033 (p <0.05) for breastfeeding mothers, then there is a relationship between the education level pregnant and lactating mothers with knowledge. The Wilcoxon test data pretest and post-test knowledge of pregnant and lactating mothers had a p-value of 0.003 (p 0.05), the effect of counselling concluded with flipchart media on the knowledge of pregnant and lactating mothers about the use of drugs.
6
Meador, K. J., G. A. Baker, N. Browning, J. Clayton-Smith, D. T. Combs-Cantrell, M. Cohen, L. A. Kalayjian, et al. "Effects of breastfeeding in children of women taking antiepileptic drugs." Neurology 75, no. 22 (November 24, 2010): 1954–60. http://dx.doi.org/10.1212/wnl.0b013e3181ffe4a9.
Full text
7
TUDOSE-TRANULIS, Ilinca, Anca Angela SIMIONESCU, Ana Maria Alexandra STĂNESCU, and Vlad DIMA. "Considerations of drug administration during breastfeeding." Romanian Journal of Medical Practice 16, S4 (August 15, 2021): 42–44. http://dx.doi.org/10.37897/rjmp.2021.s4.9.
Full textAbstract:
Breastmilk is the best nutrition for infants. Unfortunately, almost all breastfeeding mothers require medication at some point during the breastfeeding period, which sometimes leads to the cessation of breastfeeding because of false beliefs about the true risk for the infant. Many prospects drugs information about side effects avoid any administration during pregnancy or in the postpartum period; also, because of fear, mothers choose to stop breastfeeding out, and general practitioners or pediatrist calculate lower doses to administrate. In this article, we want to draw attention to that even though there are no trials in neonates; we have much data on the safe use of medication during breastfeeding. In conclusion, we want to increase awareness about the necessity of increasing knowledge for mothers and healthcare personnel about indications, contraindications, and side effects of most used medication during breastfeeding.
8
Melikova, Shahla Yagub. "Pregnancy in women with epilepsy." HEALTH OF WOMAN, no. 8(124) (October 30, 2017): 61–64. http://dx.doi.org/10.15574/hw.2017.124.61.
Full textAbstract:
Epilepsy is one of the most common serious neurological diseases. Many publications relating to interaction of epilepsy and pregnancy have been studied. Women with epilepsy experience a number of physical and social problems associated with obstetric risk, the risk of seizures during pregnancy. Generalized epileptic seizures may have a direct damaging effect on the fetus, although there is no conclusive evidence for a significant increase in the incidence of complications during pregnancy in women with epilepsy. Antenatal exposure to antiepileptic drugs, especially in high-dose and polytherapy, increases the risk of congenital malformations. There are concerns regarding the effects of antiepileptic drugs on infants during breastfeeding. However, the risk of complications associated with the epilepsy and the effects of antiepileptic drugs on the fetus may be reduced by joint monitor by neurologist-epileptologist and obstetrician. Key words: pregnancy, antiepileptic drugs, epilepsy, monotherapy, polytherapy.
9
Golovach, I. Yu, and Ye D. Yehudina. "Perygravid management of rheumatic disease." HEALTH OF WOMAN, no. 2(148) (March 30, 2020): 42–51. http://dx.doi.org/10.15574/hw.2020.148.42.
Full textAbstract:
Management of inflammatory rheumatic diseases in preconception period, pregnancy and breastfeeding has undergone significant changes over the past few years. Modern therapy, including biological and targeted synthetic disease modifying drugs, has significantly improved the control of rheumatic diseases, which has led to an increase in the patients’ number planning a pregnancy with serious diseases. When consulting such patients, it is necessary to discuss the possible time of conception (regarding the activity of the disease), the effect of the disease on pregnancy and pregnancy on the disease, as well as the potential need to change the regimen of medications during pregnancy and breastfeeding. This review summarizes information on the effects of pregnancy on various rheumatic diseases and vice versa, changes in therapy and monitoring of patients with rheumatic diseases before, during and after pregnancy. Women with inflammatory rheumatic diseases need advice on drug therapy before planning pregnancy, during pregnancy, and breastfeeding. Safe disease-modifying drugs that can be taken during pregnancy are hydroxychloroquine, sulfosalazine, azathioprine, and cyclosporine. Glucocorticoids and non-steroidal anti-inflammatory drugs can also be taken up to 32 weeks of gestation. Most inhibitors of tumor necrosis factor (anti-TNF) are also safe during pregnancy. During pregnancy, a clear monitoring of the activity of the disease is necessary, control of the level of autoantibodies, especially anti-SSA / Ro and anti-SSB / La and antiphospholipid antibodies, an assessment of the degree of organ dysfunction, especially kidney damage. Presented are modern approaches to optimizing the management of inflammatory rheumatic disease during pregnancy. For patients with inflammatory rheumatic diseases, a successful pregnancy outcome is optimized by creating an individual plan to suppress disease activity using a targeted approach. Key words: pregnancy, rheumatic diseases, treatment, lactation, management tactics, drugs.
10
Hanifa, Dina, Sri Rahayu, Isnu Kurnia Nugrahaeni, and Noviyati Rahardjo Putri. "Herbal Lactagogum And Breastfeeding Mother's Breast Milk Production: A Sistematic Review." Journal of Midwifery Science: Basic and Applied Research 3, no. 2 (December 16, 2021): 55–68. http://dx.doi.org/10.31983/jomisbar.v3i2.8115.
Full textAbstract:
Background: Exclusive breastfeeding has a major contribution to the growth and development of toddlers, especially at 1,000 HPK. The coverage of exclusive breastfeeding in 2017 was still low at 35.7% compared to the WHO and the Ministry of Health's 2019 target which is 50%. One of the efforts to increase the coverage of exclusive breastfeeding is increase the quantity and quality of breast milk production, so as to increase the mother's motivation to give exclusive breastfeeding. Efforts to increase by using drugs / herbs are known as laktagogums. Lactagogum drugs are rarely known because they are relatively expensive. Therefore, the use of alternative lactogogum herbs derived from plants that can be consumed by breastfeeding mothers is very necessary. Objective: The purpose of this study was to analyze the herbal lactagogum on breast milk production. Methods: Literature review using the keywords laktagogum and herbs for breast milk production. Articles retrieved from Google Scholar, Science Direct, and Pub Med in the period 2009 to February 2019. In addition, relevant text books and guidelines were used to add further information or additional reports that were not identified in the electronic search. Results: Based on several experimental studies, it was shown that torbangun leaves, young papayas, moringa leaves, katuk leaves and banana buds contain chemical compounds that can stimulate the synthesis of prolactin and oxytocin to increase the production and secretion of breast milk. Conclusion: Lactagogum torbangun leaves, young papaya fruit, moringa leaves, katuk leaves and banana buds have a positive effect on increasing breast milk production. Keywords: herbs, lactagogum, breast milk production
11
Hodel, E. M., C. Marzolini, C. Waitt, and N. Rakhmanina. "Pharmacokinetics, Placental and Breast Milk Transfer of Antiretroviral Drugs in Pregnant and Lactating Women Living with HIV." Current Pharmaceutical Design 25, no. 5 (June 3, 2019): 556–76. http://dx.doi.org/10.2174/1381612825666190320162507.
Full textAbstract:
Background:Remarkable progress has been achieved in the identification of HIV infection in pregnant women and in the prevention of vertical HIV transmission through maternal antiretroviral treatment (ART) and neonatal antiretroviral drug (ARV) prophylaxis in the last two decades. Millions of women globally are receiving combination ART throughout pregnancy and breastfeeding, periods associated with significant biological and physiological changes affecting the pharmacokinetics (PK) and pharmacodynamics (PD) of ARVs. The objective of this review was to summarize currently available knowledge on the PK of ARVs during pregnancy and transport of maternal ARVs through the placenta and into the breast milk. We also summarized main safety considerations for in utero and breast milk ARVs exposures in infants.Methods:We conducted a review of the pharmacological profiles of ARVs in pregnancy and during breastfeeding obtained from published clinical studies. Selected maternal PK studies used a relatively rich sampling approach at each ante- and postnatal sampling time point. For placental and breast milk transport of ARVs, we selected the studies that provided ratios of maternal to the cord (M:C) plasma and breast milk to maternal plasma (M:P) concentrations, respectively.Results:We provide an overview of the physiological changes during pregnancy and their effect on the PK parameters of ARVs by drug class in pregnancy, which were gathered from 45 published studies. The PK changes during pregnancy affect the dosing of several protease inhibitors during pregnancy and limit the use of several ARVs, including three single tablet regimens with integrase inhibitors or protease inhibitors co-formulated with cobicistat due to suboptimal exposures. We further analysed the currently available data on the mechanism of the transport of ARVs from maternal plasma across the placenta and into the breast milk and summarized the effect of pregnancy on placental and of breastfeeding on mammal gland drug transporters, as well as physicochemical properties, C:M and M:P ratios of individual ARVs by drug class. Finally, we discussed the major safety issues of fetal and infant exposure to maternal ARVs.Conclusions:Available pharmacological data provide evidence that physiological changes during pregnancy affect maternal, and consequently, fetal ARV exposure. Limited available data suggest that the expression of drug transporters may vary throughout pregnancy and breastfeeding thereby possibly impacting the amount of ARV crossing the placenta and secreted into the breast milk. The drug transporter’s role in the fetal/child exposure to maternal ARVs needs to be better understood. Our analysis underscores the need for more pharmacological studies with innovative study design, sparse PK sampling, improved study data reporting and PK modelling in pregnant and breastfeeding women living with HIV to optimize their treatment choices and maternal and child health outcomes.
12
Lobkova, Nelya, and Edwin W. Wolf. "Performing Elective Surgery on the Breastfeeding Patient." Foot & Ankle Specialist 7, no. 3 (April 25, 2014): 225–30. http://dx.doi.org/10.1177/1938640014532132.
Full textAbstract:
The prevalence of breastfeeding among women in the United States is increasing along with the understanding of the importance of continually and exclusively breastfeeding an infant in the first half year of life. Modern necessities and problems evoke questions about what medications can be safely utilized by a breastfeeding mother and which procedures she may safely undergo. Planning elective surgery for a patient who is breastfeeding is a challenge because of insufficient studies regarding medication safety, apprehension among patients, and inadequate information from care providers. Nonetheless, information on the pharmacokinetics of drugs in the maternal system, the possible adverse effects to the infant, and how to minimize drug exposure to the infant is easily accessible to both patients and their surgeons. Positively informed providers and breastfeeding mothers who elect to undergo surgery, willing to take the proper steps and precautions, ensure healthy outcomes postoperatively.
13
Powell, Elizabeth M. "Breast is Still Best: No Harmful Effects of Breastfeeding in Women Taking Antiepileptic Drugs." Epilepsy Currents 15, no. 1 (January 2015): 10–12. http://dx.doi.org/10.5698/1535-7597-15.1.10.
Full text
14
Hasibuan, Nurul Azizah, and Evi Desfauza. "PENGARUH PEMBERIAN PUDING SARI PEPAYA TERHADAP PRODUKSI ASI PADA IBU POSTPARTUM DI BPM SUGIHARTI LUBUK PAKAM TAHUN 2020." COLOSTRUM : Jurnal Kebidanan 2, no. 1 (January 15, 2021): 78–84. http://dx.doi.org/10.36911/colostrum.v2i1.859.
Full textAbstract:
Introduction: One of the obstacles that occur in postpartum mothers is not giving exclusive breastfeeding. According to UNICEF data (2018) the coverage of exclusive breastfeeding in the world is only around 36%. Papaya fruit provision to postpartum mothers is one of the efforts to increase breast milk production, the aim of this study was to find out the effect of papaya juice pudding provision to breast milk production in postpartum mothers at Sugiharti midwifery clinic of Lubuk Pakam in 2020.
Methods: This type of research was Quasi Experiment with a Posttest Only Control Group design and the sampling used was purposive sampling. Samples were 30 postpartum mothers, namely 15 experimental groups who gave papaya juice pudding and 15 control groups who were not given papaya juice pudding with the inclusion criteria of normal postpartum mothers, infants who were given early breastfeeding initiation, mothers who did not consume drugs, herbal / Other breastfeeding smoothing supplements, willing to take part in the research through Informed Consent, were given in the experimental group papaya juice pudding while in the control group papaya juice pudding was not given.
Results and Discussion: This research on giving papaya juice pudding was conducted for 7 consecutive days and then measured the volume of breast milk using Breastpump. Based on the results of the study showed that the average milk production of the experimental group was 128.00 and the average milk production of the control group was 91.20, so the difference in breast milk production was 36.8. Then it can be seen that the results of the Independent T-Test test obtained a P-Value of 0.000 (? <0.005).
Conclusion: The provision of papaya juice pudding has an effect on increasing breast milk production in postpartum mothers. It is suggested to midwifery clinic to utilize papaya fruit which can be processed into papaya juice pudding to increase breast milk production in postpartum mothers so that mothers give exclusive breastfeeding to their babies.
15
Tillery, Erika E., Rikki L. Tonet, and Christine A. Trahan. "Oh baby! A review of mood stabilizers for bipolar disorder in the child-bearing woman." Mental Health Clinician 3, no. 2 (August 1, 2013): 61–70. http://dx.doi.org/10.9740/mhc.n163522.
Full textAbstract:
Background: Bipolar disorder is a brain disorder that can cause abnormal changes in a person's mood, cognitive function, and quality of life. Patients who are diagnosed with bipolar disorder often have intense emotional states that are characterized by either manic or depressive episodes. There is a strong correlation between women of child bearing age and the initial age of onset of the disease. Mood stabilizing drugs have been the mainstay of treatment for many decades; however, there is strong data supporting the teratogenic effects of these drugs on the fetus in pregnant and lactating women. Methods: Review articles, clinical trials, and practice guidelines were located using online databases PubMed, CINAHL, IDIS, and Medline. Search terms included at least one of the following: “bipolar disorder”, “breast-feeding”, “carbamazepine”, “epilepsy”, “lactation”, “lamotrigine”, “lithium”, “mood stabilizers”, “pregnancy”, “valproate”, and “valproic acid”. Online clinical databases Clinical Pharmacology and Lexi-Comp were also used in the study. Results: All mood stabilizer drugs are found to cause malformations in fetal development if given during the first trimester of pregnancy, thus use should be avoided if possible. Lamotrigine was found to cause lowest risk of adverse effects in both the mother and fetus during pregnancy; however, it should be avoided in breastfeeding women as it readily passes into breast milk. Lithium use during pregnancy and lactation has been associated with severe malformations and should only be used if maternal benefit outweighs fetal risk. Valproate is considered harmful to both the mother and fetus during pregnancy, but may be a compatible option for breastfeeding. Carbamazepine is found to cause serious malformations with the developing fetus as well as metabolic effects with the mother; however, it is found to cause little effects in breastfed infants as it does not readily pass through breast milk. Conclusion: The use of medications in pregnant and breastfeeding women suffering from bipolar disorder must be carefully considered for impacts on fetal development as well as risks to the mother. Mood stabilizers are readily marketed as first line treatment options for bipolar disorder; however, their use in pregnant and lactating women may cause limitations as preferred therapy. Studies show that though lamotrigine has not been as well studied as the other agents, it may be the best recommendation during pregnancy, for both fetal and maternal health concerns. For breastfeeding women, carbamazepine has been shown to be the better option, as it carries the lowest risk of adverse events to the infant.
16
Ovchinnikov, A. V., and T. I. Vazagaeva. "Modern approaches to the pharmacotherapy of postpartum depression." Meditsinskiy sovet = Medical Council, no. 11 (August 8, 2020): 70–81. http://dx.doi.org/10.21518/2079-701x-2020-11-70-81.
Full textAbstract:
Postpartum or postnatal depression (PDD) is a common disorder that has serious negative effects on a woman’s health and increases the risk for a child’s emotional, social, and cognitive development outcomes. There are a few unresolved problems in the PDD pharmacotherapy caused by the lack of evidence about drug safety and effectiveness. This review provides a timely update on the current understanding of approaches to the diagnosis and treatment of patients with PDD as part of recurrent depression and bipolar disorder, the features of pharmacotherapy in the postpartum period depending on the manifestations and course of the disease. In accordance with the current guidelines, the treatment of PDD requires the use of the same standard approaches, as in the treatment of depression not associated with pregnancy and childbirth, while it is recommended to refuse breastfeeding in most cases, which runs somewhat contrary to the literature. Several clinical studies have shown that some psychotropic drugs are safe to use in breastfeeding mothers as they demonstrate low transfer into breast milk and rarely cause adverse events in infants. With this respect, sertraline is regarded as the first choice among antidepressants (AD), and quetiapine and valproate among normotimics, however, the limited amount of data does not allow us to make final conclusions about short-term and long-term risks for children. The article also outlines promising directions in the development of new neurosteroid-based antidepressant drugs for the treatment of PDD. Their mechanism of action is mainly associated with a modulating effect on GABAergic neurotransmission.
17
Nakijoba, Ritah, Aida Nakayiwa Kawuma, Francis Williams Ojara, Jovia C. Tabwenda, Jacqueline Kyeyune, Christine Turyahabwe, Simon Peter Asiimwe, et al. "Pharmacokinetics of drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study." Wellcome Open Research 8 (January 6, 2023): 12. http://dx.doi.org/10.12688/wellcomeopenres.18512.1.
Full textAbstract:
Background: Data surrounding the exposure of the breastfed infant to drugs and any associated risks are sparse. Drugs are transferred to milk in small quantities, and many have been used without obviously noticeable infant toxicity for many years – this lack of a ‘safety signal’ has further reduced the interest in studying mother-to-infant transfer of the drugs. In sub-Saharan Africa, pregnant women are at risk of Plasmodium falciparum infection, and one in four women have evidence of placental infection at the time of delivery. Artemisinin-based combination therapies (ACTs), primarily artemether-lumefantrine (AL), are the current first-line treatment for uncomplicated Plasmodium falciparum malaria, with the same dosing recommendations in breastfeeding women as those in the adult population. Dihydroartemisinin-piperaquine (DP) is routinely used as an alternative to AL in Uganda. However, lactation pharmacokinetics (PK) of ACTs are unknown. Pharmacokinetic characterization of anti-malarial transfer to breast milk and breastfed infants is crucial in understanding the potential consequences to the infant, in terms of therapeutic- and prophylactic effects as well as potential toxicity. Methods: This observational study will enroll 30 mother-infant pairs, and aims to characterize the breastmilk transfer of antimalarial medications (AL and DP) to infants when these ACTs are administered to mothers as part of treatment for uncomplicated malaria. In addition, we will assess the mental health of the breastfeeding mothers enrolled as well as the well-being of their children. PK samples of maternal blood, breastmilk and breastfeeding infant’s blood will be obtained at specific times points. Pharmacokinetic data will be analyzed using a population pharmacokinetic approach. Conclusions: We anticipate that findings from this research will guide to develop a PK model describing lumefantrine and piperaquine disposition and will provide a framework to foster other lactation pharmacokinetic studies in different disease areas.
18
Rizqiea, Noerma Shovie. "The Exclusive Breastfeeding Booklet for Knowledge and Skills Mother." Jurnal Ilmiah Kesehatan Media Husada 8, no. 1 (March 21, 2019): 22–31. http://dx.doi.org/10.33475/jikmh.v8i1.193.
Full textAbstract:
Exclusive breastfeeding is breast milk given to babies from birth for six months, without adding and / or replacing with other foods or drinks (except drugs, vitamins and minerals). Booklet is one of the media that is used to convey health messages in the form of books, both writing and drawing. The results of a preliminary study obtained from the Village Midwife said that the majority of mothers found it difficult to give exclusive breastfeeding to their children so that she gave up and gave formula milk. The aim of the study: to determine the effect of giving booklets on exclusive breastfeeding to the knowledge and skills of mothers in Gondangrejo Community Health Center, Karanganyar Regency. Method: Type of research experiment with the design of pre and post test without control. The sampling technique used by researchers is non probability sampling with a consecutive sampling method. The number of samples used in this study were 45 respondents with an added 10% estimate of the proportion of drop outs, so the sample amounted to 50 respondents. Results: The normality test obtained results p 0,000 (p <0.05) so that the distribution of data was said to be abnormal. The analysis used was the Wilcoxon test, the results obtained p 0,000 (p <0.05), so that it showed a significant difference in knowledge between before being given the booklet and after giving the booklet. The frequency distribution of skills shows that 64% of respondents get the maximum score (12). Conclusion: The provision of booklets increases the knowledge and skills of mothers in giving exclusive breastfeeding.
19
Dyrka, Kamil, Miłosz Miedziaszczyk, Edyta Szałek, and Katarzyna Łącka. "Drugs used in viral diseases – their mechanism of action, selected adverse effects and safety during pregnancy and lactation." Postępy Higieny i Medycyny Doświadczalnej 73 (October 10, 2019): 491–507. http://dx.doi.org/10.5604/01.3001.0013.5249.
Full textAbstract:
Viruses cause many diseases in humans, from self-resolving diseases to acute fatal diseases. New antiviral drugs are registered and the efficacy and safety of other medicines are evaluated in clinical trials. Antiviral therapy significantly reduces the morbidity and mortality of patients, but may cause numerous adverse effects. The aim of this study is to discuss the mechanism, selected adverse effects of available antivirals and their safety during pregnancy and lactation. The authors refer to the classification of drugs used during pregnancy and recommendations for breastfeeding, which, for example, definitely prohibit the use of ribavirin. The authors also pay attention to the monitoring of selected diagnostic parameters to improve the treatment results. Clinicians should limit adverse effects through an individual, specific to the patient treatment regimen. Physicians should pay special attention to the use of antiviral drugs in pregnant and breast-feeding women. Clinical trials should be continued to increase knowledge about the adverse effects of antiviral medicines.
20
Ramos Santos Jr, Wilson José, and Bruno Spinosa De Martinis. "Psychoactive substances in human breast milk: a review of analytical strategies for their investigation." Bioanalysis 12, no. 17 (September 2020): 1263–74. http://dx.doi.org/10.4155/bio-2020-0155.
Full textAbstract:
WHO recommends breastfeeding for the first 6 months of newborn's life. Due to its physicochemical properties, breast milk may contain undesirable components originated from mother's feeding, medication and illicit drugs consumption. Some of these substances transferred from bloodstream to milk and delivered to the infant can cause harmful effects. For the last decades, analytical advances enabled the analysis of several substances in milk using different techniques. Thereby, it is possible to evaluate infant's level of exposure to these substances. This review presents the information published in the main scientific dissemination media about psychoactive drugs investigation in human breast milk, involving the sample preparation techniques and chromatographic validated methods developed in the past 10 years.
21
Zingler, Emilie, Angélica Amato, Alysson Zanatta, Maria Vogt, Miriam Wanderley, Coríntio Mariani Neto, and Alberto Zaconeta. "Lactation Induction in a Commissioned Mother by Surrogacy: Effects on Prolactin Levels, Milk Secretion and Mother Satisfaction." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 39, no. 02 (February 2017): 086–89. http://dx.doi.org/10.1055/s-0037-1598641.
Full textAbstract:
Case report of a 39-year-old intended mother of a surrogate pregnancy who underwent induction of lactation by sequential exposure to galactagogue drugs (metoclopramide and domperidone), nipple mechanical stimulation with an electric pump, and suction by the newborn. The study aimed to analyze the effect of each step of the protocol on serum prolactin levels, milk secretion and mother satisfaction, in the set of surrogacy. Serum prolactin levels and milk production had no significant changes. Nevertheless, the mother was able to breastfeed for four weeks, and expressed great satisfaction with the experience. As a conclusion, within the context of a surrogate pregnancy, breastfeeding seems to bring emotional benefits not necessarily related to an increase in milk production.
22
Bakhtiar, Bakhtiar. "Literatur review: Dukungan nutrisi untuk bayi yang lahir dari ibu dengan Covid-19." AcTion: Aceh Nutrition Journal 5, no. 2 (November 13, 2020): 210. http://dx.doi.org/10.30867/action.v5i2.398.
Full textAbstract:
COVID-19 suffered by mothers who gave birth has an impact on newborns, including the risk of possible transmission. However, all the needs of newborns must remain a priority, especially regarding protection against possible transmission and nutritional needs, especially breast milk or formula milk. The care of the baby depends on the health condition or the wishes of the mother and family. In mothers with severe COVID-19, babies must be treated separately from their mothers. Conversely, if the mother is asymptomatic, the baby can be treated together, but still according to health protocols. Two impacts on the baby are related to breastfeeding are the risk of transmission and the effects of drugs taken by the mother that can be transmitted through breast milk. There are three ways to provide nutrition for the newborn, depending on the severity of the COVID-19 that the mother is suffering from. If without symptoms, breastfeeding is direct. If symptoms are mild, breastfeeding is indirect. Meanwhile, if COVID-19 with severe symptoms, the baby is only given donor breast milk or formula milk. Provision of advanced nutrition, after treatment, is complete, the baby is still given breast milk from the mother and stops donor breast milk or formula milk.
23
Zuppa, Antonio Alberto, Paola Sindico, Claudia Orchi, Chiara Carducci, Valentina Cardiello, Piero Catenazzi, Costantino Romagnoli, and Piero Catenazzi. "Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production." Journal of Pharmacy & Pharmaceutical Sciences 13, no. 2 (May 26, 2010): 162. http://dx.doi.org/10.18433/j3ds3r.
Full textAbstract:
Poor production of breast milk is the most frequent cause of breast lactation failure. Often, physician prescribe medications or other substances to solve this problem. The use of galactogogues should be limited to those situations in which reduced milk production from treatable causes has been excluded. One of the most frequent indication for the use of galactogogues is the diminution of milk production in mothers using indirect lactation, particularly in the case of preterm birth. The objective of this review is to analyze to the literature relating to the principal drugs used as galactogogues (metoclopramide, domperidone, chlorpromazine, sulpiride, oxytocin, growth hormone, thyrotrophin releasing hormone, medroxyprogesterone). Have been also analyzed galactogogues based on herbs and other natural substances (fenugreek, galega and milk thistle). We have evaluated their mechanism of action, transfer to maternal milk, effectiveness and potential side effects for mother and infant, suggested doses for galactogogic effect, and recommendation for breastfeeding.
24
Stepans, Mary Beth Flanders, Susan L. Wilhelm, and Kurt Dolence. "Smoking Hygiene: Reducing Infant Exposure to Tobacco." Biological Research For Nursing 8, no. 2 (October 2006): 104–14. http://dx.doi.org/10.1177/1099800406290643.
Full textAbstract:
The American Academy of Pediatrics recently removed nicotine from the list of drugs contraindicated during breastfeeding. The objective of this study was to evaluate the feasibility of determining the effect of a smoking hygiene intervention on infants of breastfeeding mothers who smoke cigarettes. An experimental design with repeated measures was used. A convenience sample of 35 mother-infant dyads from seven sites was recruited and randomly assigned to the intervention or control group. Of the 27 dyads completing the study, 16 were in the experimental group and 11 were in the control group. Smoking hygiene was introduced when infants were 2 weeks old and reinforced when they were 3 and 5 weeks old. At these three data points, infant health and urinary nicotine and cotinine levels were measured, as well as the mothers' breast-milk nicotine and cotinine levels and smoking hygiene behaviors. Recruiting and retaining a sample of breastfeeding mothers who smoke proved difficult. Only 27% of women in the intervention group implemented all aspects of the smoking hygiene intervention behaviors. Repeated-measures ANOVA revealed no difference in a) infant urinary nicotine and cotinine levels or b) breast-milk nicotine and cotinine levels between the two groups. The McNemar test for related samples revealed no difference between frequency of respiratory symptoms in either the control or intervention groups when Week 2 levels were compared with levels at Weeks 3 and 5. Mothers were not successful in adhering to the smoking hygiene intervention. To adequately test interventions, strategies must be developed to help women incorporate health-promoting behaviors into their lives.
25
Gómez-Roig, M. Dolores, Rosalia Pascal, Marc Josep Cahuana, Oscar García-Algar, Giorgia Sebastiani, Vicente Andreu-Fernández, Leopoldo Martínez, et al. "Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review." Fetal Diagnosis and Therapy 48, no. 4 (2021): 245–57. http://dx.doi.org/10.1159/000514884.
Full textAbstract:
Preconception and prenatal exposure to environmental contaminants may affect future health. Pregnancy and early life are critical sensitive windows of susceptibility. The aim of this review was to summarize current evidence on the toxic effects of environment exposure during pregnancy, the neonatal period, and childhood. Alcohol use is related to foetal alcohol spectrum disorders, foetal alcohol syndrome being its most extreme form. Smoking is associated with placental abnormalities, preterm birth, stillbirth, or impaired growth and development, as well as with intellectual impairment, obesity, and cardiovascular diseases later in life. Negative birth outcomes have been linked to the use of drugs of abuse. Pregnant and lactating women are exposed to endocrine-disrupting chemicals and heavy metals present in foodstuffs, which may alter hormones in the body. Prenatal exposure to these compounds has been associated with pre-eclampsia and intrauterine growth restriction, preterm birth, and thyroid function. Metals can accumulate in the placenta, causing foetal growth restriction. Evidence on the effects of air pollutants on pregnancy is constantly growing, for example, preterm birth, foetal growth restriction, increased uterine vascular resistance, impaired placental vascularization, increased gestational diabetes, and reduced telomere length. The advantages of breastfeeding outweigh any risks from contaminants. However, it is important to assess health outcomes of toxic exposures via breastfeeding. Initial studies suggest an association between pre-eclampsia and environmental noise, particularly with early-onset pre-eclampsia. There is rising evidence of the negative effects of environmental contaminants following exposure during pregnancy and breastfeeding, which should be considered a major public health issue.
26
Ronchetti, Camilla, Federico Cirillo, Noemi Di Segni, Martina Cristodoro, Andrea Busnelli, and Paolo Emanuele Levi-Setti. "Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy—A Narrative Review." Nutrients 14, no. 8 (April 12, 2022): 1591. http://dx.doi.org/10.3390/nu14081591.
Full textAbstract:
Despite the fact that knowledge on obstetrical management of Inflammatory Bowel Diseases (IBDs) has greatly improved over the years, many patients still actively avoid pregnancy for fear of adverse maternal or neonatal outcomes, of adverse effects of pregnancy on the disease activity, of eventual IBD inheritance, or of an increased risk of congenital malformations. Indeed, though data prove that fertility is hardly affected by the disease, a reduced birth rate is nevertheless observed in patients with IBD. Misconceptions on the safety of drugs during gestation and breastfeeding may influence patient choice and negatively affect their serenity during pregnancy or lactation. Moreover, physicians often showed concerns about starting IBD medications before and during pregnancy and did not feel adequately trained on the safety of IBD therapies. IBD-expert gastroenterologists and gynecologists should discuss pregnancy and breastfeeding issues with patients when starting or changing medications in order to provide appropriate information; therefore, pre-conception counselling on an individualized basis should be mandatory for all patients of reproductive age to reassure them that maintaining disease remission and balancing the eventual obstetrical risks is possible.
27
Ding, Li, Yimin Cheng, Wei Guo, Siyue Sun, Xiangqin Chen, Tiantian Zhang, Hongwei Cheng, et al. "High Expression Level of α2-3-Linked Sialic Acids on Salivary Glycoproteins of Breastfeeding Women May Help to Protect Them from Avian Influenza Virus Infection." Molecules 27, no. 13 (July 3, 2022): 4285. http://dx.doi.org/10.3390/molecules27134285.
Full textAbstract:
Terminal sialic acids (Sia) on soluble glycoprotein of saliva play an important role in the clearance of influenza virus. The aim of this study is to investigate the alteration of sialylation on the salivary proteins of women during the lactation period and its effect on the saliva binding ability to virus. In total, 210 saliva samples from postpartum women with and without breastfeeding were collected, and the expression level of α2-3/6-linked Sia on the whole salivary proteins and specific glycoproteins of IgA and MUC5B from different groups were tested and verified using lectin microarray, blotting analysis and ELISA based method. The H1N1 vaccine and three strains of Avian influenza virus (AIV) were used for the saliva binding assay. Results showed that the variation in salivary expression level of α2-3-linked Sia was much more obvious than the α2-6-linked Sia, which was up-regulated significantly in the breastfeeding groups compared to the non-breastfeeding groups at the same postpartum stage. Furthermore, the binding abilities of salivary glycoproteins to AIV strains and H1N1 vaccine were increased in breastfeeding groups accordingly. This finding adds new evidence for the maternal benefit of breastfeeding and provides new thinking to protect postpartum women from AIV infection.
28
Martineau, Marcus, Dorian O. Haskard, and Catherine Nelson-Piercy. "Behçet's syndrome in pregnancy." Obstetric Medicine 3, no. 1 (March 2010): 2–7. http://dx.doi.org/10.1258/om.2009.090033.
Full textAbstract:
Behçet's syndrome (BS), a systemic inflammatory disease characterized by oral and genital ulceration, eye inflammation and arthritis, usually presents in the third and fourth decades of life, but is rare in pregnancy. BS is not usually associated with a detrimental effect on pregnancy outcome. In most women BS is reported to improve in pregnancy, although it may not always follow a similar course in successive pregnancies and it is not possible to predict the course of BS in a particular pregnancy. Many of the drug therapies used to treat BS are safe to use in pregnancy and in the breastfeeding mother. These include corticosteroids, azathioprine, calcineurin inhibitors and probably colchicine. Experience with use of biologics in pregnancy is increasing. Drugs used in the management of BS that should be avoided in women planning a pregnancy include methotrexate, mycophenolate mofetil, thalidomide, cyclophosphamide and chlorambucil.
29
Koukou, Zoi, Anatoli Theodoridou, Eleftheria Taousani, Angeliki Antonakou, Eleftherios Panteris, Styliani-Stella Papadopoulou, Anna Skordou, and Stavros Sifakis. "Effectiveness of Non-Pharmacological Methods, Such as Breastfeeding, to Mitigate Pain in NICU Infants." Children 9, no. 10 (October 17, 2022): 1568. http://dx.doi.org/10.3390/children9101568.
Full textAbstract:
Neonates do experience pain and its management is necessary in order to prevent long-term, as well as, short-term effects. The most common source of pain in the neonatal intensive care unit (NICU) is caused by medically invasive procedures. NICU patients have to endure trauma, medical adhesive related skin injuries, heel lance, venipuncture and intramuscular injection as well as nasogastric catheterization besides surgery. A cornerstone in pain assessment is the use of scales such as COMFORT, PIPP-R, NIPS and N-PASS. This narrative review provides an up to date account of neonate pain management used in NICUs worldwide focusing on non-pharmacological methods. Non-steroidal anti-inflammatory drugs have well established adverse side effects and opioids are addictive thus pharmacological methods should be avoided if possible at least for mild pain management. Non-pharmacological interventions, particularly breastfeeding and non-nutritive sucking as primary strategies for pain management in neonates are useful strategies to consider. The best non-pharmacological methods are breastfeeding followed by non-nutritive sucking coupled with sucrose sucking. Regrettably most parents used only physical methods and should be trained and involved for best results. Further research in NICU is essential as the developmental knowledge changes and neonate physiology is further uncovered together with its connection to pain.
30
Antonoaea, Paula, Nicoleta Todoran, Emőke Rédai, Robert Alexandru Vlad, Magdalena Bîrsan, Aura Rusu, and Adriana Ciurba. "Ibuprofen in the current practice of the pharmacist in the community pharmacy." Romanian Journal of Pharmaceutical Practice 13, no. 3 (September 30, 2020): 115–20. http://dx.doi.org/10.37897/rjphp.2020.3.1.
Full textAbstract:
The pharmacist from the community pharmacy plays a key role in the case of patients who seek directly for pathologies related to pain. Being a health specialist, he has the ability to offer pharmaceutical healthcare for drugs that need a medical prescription and also for the ones that are registered as OTC’s. Ibuprofen (IBU) is a part of the drug group called nonsteroidal anti-inflammatory drugs (NSAIDs) being registered in Romania under 17 pharmaceutical formulation by the National Agency of Drugs and Medical Devices. Due to its pharmacological profile which consists of a low risk of gastrointestinal side effects, IBU is an OTC recommended and frequently prescribed for decreasing the low and moderate pain. World Health Organization (WHO) indicates IBU as a drug that can be used to babies aged over three months. Through this paper, we try to analyze the pharmacist’s vision from the community pharmacy in IBU recommendation. In this paper were mentioned some legal aspects that are linked to the pharmacist competences, and also its approach regarding IBU recommendation during pregnancy and breastfeeding and also to children and to a category of patients who have various associated pathologies.
31
., Rusmini, Any Ashari, and Yuni Kusmiyati. "Effect of Acupressur and Oxytocin Massage on Output Time and Adequacy Of Breast Milk in Post Partum Mothers at Panembahan Senopati Hospital, Bantul." JURNAL KEBIDANAN KESTRA (JKK) 5, no. 1 (October 31, 2022): 37–44. http://dx.doi.org/10.35451/jkk.v5i1.1195.
Full textAbstract:
Breastfeeding provides benefits for both mother and baby. Breasti imilk containsi imany nutrientsi ithat babiesi need ini ithe ifirst 6i (six) months after birth. There are factors that influence exclusive breastfeeding that can inhibit the secretion of the oxytocin hormone. One way to stimulate the oxytocin hormone and increase comfort is by oxytocin massage. The prolactin and oxytocin hormones play a very important role in the adequacy of breast milk production. One way to generate the let down reflex is by doing therapy acupressure. The purpose of this study was to analyze the effect of giving little finger acupressure and oxytocin massage to the output time and adequacy of breastfeeding in postpartum mothers at Panembahan Senopati Hospital, Bantul. The design of this research is the Randomized Controlled Trial (RCT) with a quantitative approach. The population in this study were all postpartum mothers who experienced vaginal delivery at the Panembahan Senopati Hospital Bantul in 2021, as many as 166 people. The number of samples in this study was 70 postpartum mothers who met the inclusion criteria based on the calculation of the slovin formula. The results showed that acupressure had more effect on the time of output and the adequacy of breast milk than oxytocin massage for postpartum mothers at RSUD Panembahan Senopati Bantul.
32
McNeilly, Alan S. "Lactational control of reproduction." Reproduction, Fertility and Development 13, no. 8 (2001): 583. http://dx.doi.org/10.1071/rd01056.
Full textAbstract:
In most mammalian species lactation suppresses fertility. There is no doubt that it is the suckling stimulus that provides the controlling signal, and, in human reproduction, this is the only truly physiological signal that suppresses fertility in normally nourished, healthy women. In breastfeeding women, the return of normal fertility follows a relatively well-defined path progressing through: an almost complete inhibition of gonadotrophin-releasing hormone/luteinizing hormone (GnRH/LH) pulsatile secretion in the early stages of lactation; return of erratic pulsatile secretion with some ovarian follicle development associated with increases in inhibin B and oestradiol; a resumption of apparently normal follicle growth associated with a normal increase in oestradiol, but often an absence of ovulation, or formation of an inadequate corpus luteum; and a return to normal ovulatory menstrual cycles. A key element in controlling the rate of this progression is the impact of the suckling stimulus on the GnRH pulse generator, a common feature of lactation in those species for which there is information. The variability in the duration of lactational amenorrhoea between women is related to the variation in the strength of the suckling stimulus, a unique situation between each mother and baby. Full breastfeeding can provide a reliable contraceptive effect in the first 6 to 9 months, but the precise mechanisms whereby the suckling stimulus affects GnRH pulsatile secretion remain unknown. Many studies on the hypothalamic pathways that might be involved in the translation of the neural suckling stimulus to suppression of hypothalamic GnRH secretion have been undertaken, principally in rats. In women, suckling increases the sensitivity of the hypothalamus to the negative feedback effect of oestradiol on suppressing the GnRH/LH pulse generator, a mechanism that appears to be common across species. In contrast, the role of prolactin in the control of GnRH appears to be species-dependent, with the importance varying from none to an important role in late or throughout lactation. In women, there is little evidence for a role of leptin, opioids or dopamine, although this may merely reflect the ethical dilemma of being able to give sufficient drug to test the system in the mother since these drugs will pass through the breast milk to the baby. Regardless of mechanism, practical guidelines for using breastfeeding as a natural contraceptive have been developed, which allows mothers to utilize the only natural suppressor of fertility in women as an effective means of spacing births.
33
Chaparro, María, María G. Donday, Francisco Abad-Santos, Francisco Javier Martín de Carpi, Miguel Ángel Maciá-Martínez, Dolores Montero, Diana Acosta, Yanire Brenes, and Javier P. Gisbert. "The safety of drugs for inflammatory bowel disease during pregnancy and breastfeeding: the DUMBO registry study protocol of GETECCU." Therapeutic Advances in Gastroenterology 14 (January 2021): 175628482110180. http://dx.doi.org/10.1177/17562848211018097.
Full textAbstract:
Background: Active disease during conception and pregnancy in women with inflammatory bowel disease (IBD) increases the risk of pregnancy complications and adverse neonatal outcomes. The use of IBD treatments during pregnancy should be weighed against their adverse effects on the neonate, but longer-term safety data and data on serious infection rates and malignancies postnatally are lacking, particularly for newer drugs, such as tofacitinib, vedolizumab and ustekinumab. Methods: This ongoing, prospective registry study being conducted at 70 centres in Spain is enrolling pregnant women who are ⩾18 years, are at any point in pregnancy up to the end of the second trimester and have a diagnosis of Crohn’s disease, ulcerative colitis or unclassified IBD. Patients will receive treatment decided independently by their IBD specialist. Each incident gestation will be followed up through pregnancy and the first 4 years postnatally. Three cohorts will be compared: biologicals exposed, immunomodulatory exposed and non-exposed. The primary endpoint is the risk of severe infection in newborns postnatally up to 4 years of age; other endpoints include serious adverse events (SAEs) such as pregnancy and delivery complications, neonatal SAEs, development [Ages and Stages Questionnaire-3 (ASQ3)], and malignancy incidence, up to 4 years of age. IBD specialists will collect maternal data (baseline/end of each trimester/1 month post-delivery), neonatal birth data, and the SAE and ASQ3 data in children exposed during pregnancy, reported every 3 months by the mother. Statistical analysis will include summary statistics for quantitative variables, comparisons of qualitative variables with significance set at p < 0.025 and a binary logistic regression model to determine the risk factors for severe infections. Results: Enrolment began in September 2019 and study completion is expected in September 2028. Conclusions: This prospective, controlled study will provide evidence on the long-term safety profile in children after intrauterine and lactation exposure to biological and immunomodulatory IBD treatments, including data on postnatal severe infections, development and malignancies. ClinicalTrials.gov identifier: NCT03894228
34
Kharitonova, Nataliya A., Milana A. Basargina, Mariya S. Illarionova, Marina I. Nesterovich, Mariya D. Mitish, and Alina A. Seliverstova. "The course of new coronavirus infection in newborn infants." Russian Pediatric Journal 25, no. 1 (March 15, 2022): 61–65. http://dx.doi.org/10.46563/1560-9561-2022-25-1-61-65.
Full textAbstract:
Introduction. To assess the features of the course of new coronavirus infection over the first month of life. Materials and methods. The article presents four clinical cases of coronavirus infection in newborn children aged 8 to 30 days, treated at the covid centre of the National Medical Research Center for Children’s Health. Results. The incubation period lasted from 2 to 10 days. The clinical picture included prevalence of hyperemic palatine arches, lethargy, impaired sucking, hyperemia of the conjunctiva, sneezing, mucous discharge from the nose, cough of varying severity. In more severe cases, an elevation in body temperature, a change in the auscultatory picture of lungs, abnormalities in the electrocardiogram. In the general blood test, there was noted anaemia, relative and absolute neutropenia, lymphocytosis and monocytosis; enlargement of activated partial thromboplastin time, increasing the level of D-dimer in the coagulogram. Computed tomography of the chest showed focal infiltrative changes in the lung tissue or uneven pneumatisation. Conclusion. Our observations show coronavirus infection in newborns, most often to show a mild and moderate course, which does not require the appointment of antibacterial drugs and hormonal, and anticoagulant therapy without strict indications. According to the recommendations of the World Health Organization, the mother, and baby should remain together throughout the day, regardless of the suspicion or confirmation of a viral infection. To date, there is no conclusive evidence mother-to-child transmission of COVID-19 through breastfeeding is possible, and the benefits of breastfeeding far outweigh the minimal risk of infection. In addition, IgA and IgG to SARS-CoV-2, detected in milk, neutralise the effect of the virus.
35
Allegaert, Karel. "Rational Use of Medicines in Neonates: Current Observations, Areas for Research and Perspectives." Healthcare 6, no. 3 (September 14, 2018): 115. http://dx.doi.org/10.3390/healthcare6030115.
Full textAbstract:
A focused reflection on rational medicines use in neonates is valuable and relevant, because indicators to assess rational medicines use are difficult to apply to neonates. Polypharmacy and exposure to antibiotics are common, while dosing regimens or clinical guidelines are only rarely supported by robust evidence in neonates. This is at least in part due to the extensive variability in pharmacokinetics and subsequent effects of medicines in neonates. Medicines utilization research informs us on trends, on between unit variability and on the impact of guideline implementation. We illustrate these aspects using data on drugs for gastroesophageal reflux, analgesics or anti-epileptic drugs. Areas for additional research are drug-related exposure during breastfeeding (exposure prediction) and how to assess safety (tools to assess seriousness, causality, and severity tailored to neonates) since both efficacy and safety determine rational drug use. To further improve rational medicines use, we need more data and tools to assess efficacy and safety in neonates. Moreover, we should facilitate access to such data, and explore strategies for effective implementation. This is because prescription practices are not only rational decisions, but also have psychosocial aspects that may guide clinicians to irrational practices, in part influenced by the psychosocial characteristics of this population.
36
Nordin, Z. M., I. A. Bakar, Muhammad Nor Omar, and Azizah Mahmood. "Effect of consuming lactogenic biscuits formulated with banana (Musa x paradisiaca) flower flour on expressed breast milk (EBM) among lactating working women." Food Research 4, no. 2 (September 30, 2019): 294–300. http://dx.doi.org/10.26656/fr.2017.4(2).292.
Full textAbstract:
The most common reasons given for breastfeeding discontinuation among working women is insufficient or low milk supply which related to physiological and psychological factors. In this case, natural galactagogue is suggested as an alternative for lactating women to augment expressed breast milk supply, instead of using drugs as a milk booster. This study investigated the banana flower of Musa x paradisiaca for its galactogenic property on lactating working women. Formulations containing banana flower flour (BFF) and wheat flour with ratio of 50:50 were consumed by randomised lactating working women. A total of 58 mother-infant pairs were assigned to two groups which were placebo group (n=29) who consumed plain biscuits (without addition of BFF) and experimental group (n=29) who consumed prototype biscuits. Expressed breast milk (EBM), anthropometric indices of mothers and infants were recorded before and after the consumption of the biscuits. The result showed that EBM volume after consuming lactogenic biscuits among experimental group was significantly higher compared to placebo groups. The index of mother’s BMI change after the intervention was not statistically significantly different between the two groups (p>0.05). However, the BMI for age index after the intervention was significantly different among the infants (p<0.05), which means that lactogenic biscuit also contributes to the infants' growth status. The usage of banana flower as a galactagogue was useful to help increasing maternal milk production among lactating working women.
37
Jügens, TP, C. Schaefer, and A. May. "Treatment of Cluster Headache in Pregnancy and Lactation." Cephalalgia 29, no. 4 (April 2009): 391–400. http://dx.doi.org/10.1111/j.1468-2982.2008.01764.x.
Full textAbstract:
Cluster headache is a rare disorder in women, but has a serious impact on the affected woman's life, especially on family planning. Women with cluster headache who are pregnant need special support, including the expertise of an experienced headache centre, an experienced gynaecologist and possibly a teratology information centre. The patient should be seen through all stages of the pregnancy. A detailed briefing about the risks and safety of various treatment options is mandatory. In general, both the number of medications and the dosage should be kept as low as possible. Preferred treatments include oxygen, subcutaneous or intranasal sumatriptan for acute pain and verapamil and prednisone/ prednisolone as preventatives. If there is a compelling reason to treat the patient with another preventative, gabapentin is the drug of choice. While breastfeeding, oxygen, sumatriptan and lidocaine for acute pain and prednisone/prednisolone, verapamil, and lithium as preventatives are the drugs of choice. As the individual pharmacokinetics differ substantially, adverse drug effects should be considered if unexplained symptoms occur in the newborn.
38
Myasnyankin, M. Yu, and V. V. Anisimov. "Experience in treating breast pathology in outpatient practice." Нospital-replacing technologies:Ambulatory surgery, no. 1-2 (June 8, 2020): 95–102. http://dx.doi.org/10.21518/1995-1477-2020-1-2-95-102.
Full textAbstract:
Introduction. According to epidemiological researches, such mammary gland disease as fibrocystic breast disease takes the leading place in the structure of pre-tumor diseases in women. Pathological cell proliferation is the common starting point for pathogenesis of both mastopathy and breast cancer. Patients with fibrocystic breast disease complain of pain unrelated to the menstrual cycle in the area of the mammary glands, swelling of breast tissue, nipple discharge. An important problem is the effective treatment of mastitis and lactostasis, during and after which the possibility of breastfeeding was maintained. Mastitis is a formidable complication of the postpartum period and the cause of lactation failure. For a long time, all patients with infectious mastitis underwent surgical treatment of the area of infection with subsequent drainage. As a rule, with the prescription of broad spectrum antibiotic drugs. Often, against the background of such stress for the body the ability to breastfeed dies down. Timely diagnosis and adequate treatment of mastitis and lactostasis help to preserve breastfeeding and improve the health of mother and child. Treatment of mastitis and lactostasis, fibrocystic breast disease is a complex problem of modern mammology.Aim. This paper presents a pathogenetic approach to the treatment of fibrocystic breast disease from the point of view of evidence-based medicine using micronized progesterone. In order to avoid surgical interventions on the mammary glands and to preserve the maximum possible period of breastfeeding, we studied and proposed the method of mini-invasive and evidence-based approach to the treatment and prophylaxis of mastitis and lactostasis using a drug containing the strain L. Fermentum CECT5716.Materials and methods. 13 patients with mastitis symptoms were included in the study. The main complaint of all patients who applied was lactostasis (100%). According to breast ultrasound, most patients were diagnosed with infiltrative mastitis – 8 (61.5%), serous mastitis – 4 (30.7%). Only one patient was diagnosed with purulent mastitis (7.7%). After prescription of treatment for mastitis and lactostasis after 21 days of clinical and radiological mammary gland image in 10 cases (77%) without pathology, duct ectasia was found in three women, which is the physiological norm in breastfeeding. All breastfeeding women have recovered normal lactation without symptoms of lactostasis. Almost all patients according to pain VAS noted not exceeding 1 point (mean was 1 ± 0.7). In most cases, the punctate cytogram corresponded to acute inflammation and purulent inflammation, 7 (53.9%) and 6 (46.1%). Results of a bacteriological study: Staphylococcus aureus – 11 (84.6%). Three patients had mixed microflora, Staphylococcus aureus/Staphylococcus epidermidis and Staphylococcus aureus/Staphylococcus saprophyticus, 2 (15.3%) and 1 (7.7%), respectively. One patient was diagnosed with Enterococcus faecalis. These data affected the choice of therapy. All patients were prescribed therapy with a drug containing the strain of L. Fermentum CECT5716 one capsule per day for 28 days, with subsequent assessment of the therapeutic effect on the 10th, 21st days.Results. After treatment on the 10th day of control examination all the patients had galactorrhea cytogram without morphological signs of inflammation. According to the data of the bacteriological study of cultures, complete elimination of pathogenic microflora was revealed in most cases – 8 (61,5%), in 5 patients there were titers of less than 104 CFU/ml, which was the norm indicator. Clinical examples of treatment are given.Conclusions. Our experience in treating such patients with a drug containing the strain L. Fermentum CECT5716 can successfully replace the standard of medical care for the treatment of mastitis and lactostasis. However, a combination with antibiotic therapy can be used for high bacterial load and mixed microflora. In all cases (100%) on the 10th day after the start of therapy all symptoms and clinical and radiological signs of lactostasis and mastitis were cured.
39
Hayati, Kardina, Tati Murni Karo Karo, Rahmad Gurusinga, Widya ., and Latifatul Robbaniyah. "PENGARUH PEMBERIAN KACANG EDAMAME TERHADAP PRODUKSI ASI PADA IBU POST PARTUM DI KLINIK BIDAN PUTRI TANJUNG KECAMATAN KOTA KISARAN TIMUR." JURNAL KEBIDANAN KESTRA (JKK) 4, no. 1 (October 31, 2021): 15–20. http://dx.doi.org/10.35451/jkk.v4i1.813.
Full textAbstract:
During breastfeeding, mothers are recommended to increase their intake of energy, protein, calcium, iron, folic acid, and other vitamins and minerals to meet the nutritional needs of breastfeeding. In order for mothers to produce 1 liter of breast milk, additional food is needed. Edamame plant is a local food ingredient that has potential for nutrition for nursing mothers, because it contains phytosterol compounds that function to increase and facilitate breast milk production (lactagogum effect). This study aims to see whether there is an effect of giving edamame nuts to breast milk production in postpartum mothers at the Midwife Clinic Putri Tanjung, Kota Kisaran Timur District in 2021. This type of research is a Quasy Experiment Design using the one Group Pretest-Postest Design, with a total sample of 8 person. Data collection uses primary data and secondary data. The data analysis technique is using the Wilcoxon test. Based on the Wilcoxon test, the results showed that post-partum mothers gave edamame nuts pre-test and post-test with a sample of 8 respondents having a P-value (0.008) < 0.05 then H0 was rejected. test and post-test on the administration of edamame nuts on breast milk production in postpartum mothers at the Tanjung Putri Midwife Clinic, East Kisaran City District in 2021. It is recommended for health workers to provide information about giving edamame nuts as an alternative to increase breast milk production for postpartum mothers.
40
Agrawal, Manasi, Eun Soo Kim, and Jean-Frederic Colombel. "JAK Inhibitors Safety in Ulcerative Colitis: Practical Implications." Journal of Crohn's and Colitis 14, Supplement_2 (February 1, 2020): S755—S760. http://dx.doi.org/10.1093/ecco-jcc/jjaa017.
Full textAbstract:
Abstract Janus kinase inhibitors [JAKi] are a new class of small molecule drugs that modulate inflammatory pathways by blocking one or more JAK receptors, and are increasingly being used in the treatment of immune-mediated diseases. Tofacitinib, a non-selective JAKi, is now approved for moderate-to-severe ulcerative colitis [UC] that is refractory or intolerant to tumour necrosis factor inhibitors [TNFi]. Whereas tofacitinib is associated with the advantages of oral administration, rapid onset of action, and lack of immunogenicity over TNFi, there are many safety considerations to take into account such as the risk of thromboembolism, infections, and hyperlipidaemia: each with specific nuances pertaining to prevention and monitoring strategies. Considerations such as pregnancy, breastfeeding, and history of malignancy also are to be navigated with utmost caution, given that very few data are available for guidance. With the use of JAKi in the real world progressively over time, safety implications will become more lucid, including caveats pertaining to JAK selectivity and gut-selective JAKi, as well as mechanistic data pertaining to adverse effects. This Viewpoint serves as a practical guide for clinicians managing inflammatory bowel disease [IBD] patients to navigate safety concerns around JAKi, including preventive and monitoring strategies.
41
Karlowicz-Bodalska, Katarzyna, Anna Prochera, Adrianna Rogowska, Agata Muszyńska, Natalia Sauer, Ernest Kuchar, Krystyna Głowacka, and Anna Wiela- Hojeńska. "Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions." Acta Poloniae Pharmaceutica - Drug Research 79, no. 4 (November 21, 2022): 567–75. http://dx.doi.org/10.32383/appdr/154637.
Full textAbstract:
Therapeutic options are limited during pregnancy due to the safety of the foetus. Non-opioid analgesics (NOA) are among the most commonly prescribed medicaments by physicians. Many of them are available over-the-counter (OTC) without prescription and in non-pharmacy sales such as hypermarkets and petrol stations. There has been a steady increase in their sales due to their high availability, the spread of self-medication and advertising. They are used for pain of various origins, inflammatory diseases, colds and flu. Monitoring the safety of therapy with these drugs is particularly important in the population of pregnant women, due to their high popularity and the different pharmacokinetics during pregnancy. The number of clinical studies on pregnant women is very limited, so it is important to raise awareness and knowledge of the adverse effects (ADR) on the developing foetus. The aim of this study was to analyse and evaluate the safety of non-opioid analgesics in a population of pregnant women based on the results of an anonymous validated survey. It will increase the awareness and enable women to make informed decisions and consider the potential risks associated with treating or not treating pain during pregnancy and breastfeeding.
42
Al Jumah, Mohammed, Yaser Al Malik, Nuha M. AlKhawajah, Jameelah Saeedi, Ibtisam AlThubaiti, Saeed Bohlega, Reem F. Bunyan, et al. "Family Planning for People with Multiple Sclerosis in Saudi Arabia: an Expert Consensus." Multiple Sclerosis International 2021 (February 15, 2021): 1–8. http://dx.doi.org/10.1155/2021/6667006.
Full textAbstract:
More than half of all patients with multiple sclerosis (MS) in the Kingdom of Saudi Arabia (KSA) are women of childbearing age. Raising a family is an important life goal for women in our region of the world. However, fears and misconceptions about the clinical course of relapsing-remitting MS (RRMS) and the effects of disease-modifying drugs (DMDs) on the foetus have led many women to reduce their expectations of raising a family, sometimes even to the point of avoiding pregnancy altogether. The increase in the number of DMDs available to manage RRMS and recent studies on their effects in pregnancy have broadened management options for these women. Interferon beta now has an indication in Europe for use during pregnancy (according to clinical need) and can be used during breastfeeding. Glatiramer acetate is a further possible option for women with lower levels of RRMS disease activity who are, or about to become, pregnant; natalizumab may be used up to 30 weeks in patients with higher levels of disease activity. Where possible, physicians need to support and encourage women to pursue their dream of a fulfilling family life, supported where necessary by active interventions for RRMS that are increasingly evidence based.
43
Sadat Hosseini, Fatemeh, Hamid Joveini, Vahid Kohpeima Jahromi, and Nader Sharifi. "Prevention of Self-medication in Women of Reproductive Age Based on a Health Belief Model: A Quasi-experimental Study." Journal of Education and Community Health 9, no. 1 (March 30, 2022): 18–25. http://dx.doi.org/10.34172/jech.2022.4.
Full textAbstract:
Background: Women of reproductive age have important responsibilities such as pregnancy, breastfeeding, and children raising. This study aimed at surveying the effect of educational interventions, based on the health belief model (HBM), in the prevention of self-medication (SM) in women of reproductive age. Methods: This quasi-experimental study was performed on women of reproductive age in Jahrom in 2019 (January-September). Simple multi-stage random sampling was used to select the participants, and the sample size was determined 60 people for both intervention and control groups. Data collection tool was a questionnaire including demographic information and HBM construct questions. The questionnaire was completed in person by both groups before and three months after the educational intervention. The educational intervention was performed based on the HBM in the intervention group, including holding 4 educational sessions each lasting 60 minutes. The data were analyzed by SPSS 21 software using the chi-square test, paired t test, and independent t-test. Results: The results showed a significant difference between intervention and control groups in terms of knowledge, perceived severity, benefits, and barriers, as well as cues to action on the correct use of drugs after the intervention (P<0.05). Three months after the intervention, the practice mean of women in the intervention group was significantly decreased compared with the control group (P<0.001). Conclusion: Overall, educational intervention based on HBM was effective in preventing SM, but the extent of this effect varied for different HBM constructs. Nonetheless, measuring the effectiveness of the intervention based on the HBM in preventing SM behaviors requires studies with a long follow-up period.
44
Nurmala, Sara, and Cantika Zaddana. "OXYTOCIN DOSE ANALYSIS OF BREASTMILK PRODUCTION THROUGH INDUCTION LABOR." Journal of Science Innovare 2, no. 01 (December 5, 2019): 01–03. http://dx.doi.org/10.33751/jsi.v2i01.1520.
Full textAbstract:
Breast milk is the only first food that can be consumed by newborns until the age reaches six months. therefore it is very important to know by the mother who is pregnant and will give birth about the importance of breast milk. Oxytocin drugs have similar functions to the natural hormone oxytocin produced by the body. This drug serves to trigger or strengthen the contraction of the uterine muscle. Therefore, oxytocin can be used to stimulate (induce) labor and stop bleeding after childbirth. In addition, this drug can also help stimulate the release of breast milk in breastfeeding mothers. Oxytocin should be avoided by pregnant women who can not give birth normally, for example because it has a narrow pelvis, suffering from placenta previa, or having a too strong uterine contractions. Oxytocin is also prohibited for pregnant women with cephalopelvic disproportion, impaired fetal conditions, uterine damage, or a history of caesarean section. In this study we see whether there is effect of different doses of oxytocin on the quantity of breastmilk produced. oxytocin doses were administered with 3 doses of 5 UI, 10 UI and 15 UI. the dose of oxytocin is administered once per incidence of labor. maternal results obtained by oxytocin induction of 5 UI and 10 UI obtained breastmilk averaging 10 ml in the first 24 hours after delivery. and a mother with oxytocin induction 15 UI received an average breastmilk of 10 ml at 24 hours after delivery.
45
Alton, M. E., S. C. Tough, P. J. Mandhane, and A. L. Kozyrskyj. "Street drug use during pregnancy: potential programming effects on preschool wheeze." Journal of Developmental Origins of Health and Disease 4, no. 2 (November 30, 2012): 191–99. http://dx.doi.org/10.1017/s2040174412000670.
Full textAbstract:
Street drug use during pregnancy is detrimental to fetal development. Although the prevalence of wheeze is high in offspring of substance-abusing mothers, nothing is known about the role of street drug use during pregnancy in its development. We investigated the impact of maternal street drug use and distress during pregnancy on the development of wheeze and allergy in preschool children. Questionnaire data were accessed from the Community Perinatal Care trial of 791 mother–child pairs in Calgary, Alberta. Using logistic regression, the association between maternal substance use and distress during pregnancy, and wheeze and allergy at age 3 years was determined in boys and girls. After adjusting for alcohol use during pregnancy, pre- and postnatal tobacco use, preterm birth, duration of exclusive breastfeeding, daycare attendance and maternal socioeconomic status, maternal street drug use during pregnancy [odds ratio (OR): 5.02, 95% confidence interval (CI): 1.30–19.4] and severe maternal distress during pregnancy (OR: 5.79, 95% CI: 1.25–26.8) were associated with wheeze in girls. In boys, an independent association was found between severe distress during pregnancy (OR: 3.85, 95% CI: 1.11–13.3) and allergies, but there was no association with maternal street drug use. In conclusion, we found an association between maternal street drug use and wheeze in preschool girls that could not be accounted for by maternal distress, smoking or alcohol use during pregnancy. Prenatal programming effects of street drugs may explain this association.
46
Kanemura, Akari, Hitoshi Masamoto, Tadatsugu Kinjo, Keiko Mekaru, Tomohide Yoshida, Hideki Goya, and Yoichi Aoki. "Evaluation of neonatal withdrawal syndrome in neonates delivered by women taking psychotropic or anticonvulsant drugs: A retrospective chart review of the effects of multiple medications and breastfeeding." European Journal of Obstetrics & Gynecology and Reproductive Biology 254 (November 2020): 226–30. http://dx.doi.org/10.1016/j.ejogrb.2020.09.008.
Full text
47
Mullin, Sadie, Christy Burden, Judith Standing, and Francesca Neuberger. "Breastfeeding and drugs." Obstetrician & Gynaecologist 23, no. 2 (March 24, 2021): 94–102. http://dx.doi.org/10.1111/tog.12728.
Full text
48
Hotham, Neil, and Elizabeth Hotham. "Drugs in breastfeeding." Australian Prescriber 38, no. 5 (October 1, 2015): 156–59. http://dx.doi.org/10.18773/austprescr.2015.056.
Full text
49
Kim, Ai-Rhan. "Drugs and Breastfeeding." Hanyang Medical Reviews 30, no. 1 (2010): 41. http://dx.doi.org/10.7599/hmr.2010.30.1.41.
Full text
50
Barger, Bob. "Drugs and Breastfeeding." Journal of Human Lactation 8, no. 2 (June 1992): 103. http://dx.doi.org/10.1177/089033449200800233.
Full text