Journal articles: 'Breast restoration'

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Reaby, Linda L. "Breast Restoration Decision Making." Plastic Surgical Nursing 19, no. 1 (1999): 22–30. http://dx.doi.org/10.1097/00006527-199901910-00005.

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Renby, Linda L. "Breast Restoration Decision Making." Plastic Surgical Nursing 19, no. 1 (1999): 22–30. http://dx.doi.org/10.1097/00006527-199919010-00005.

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Hudson, Donald A., and Paul J. Skoll. "Single-Stage, Autologous Breast Restoration." Plastic and Reconstructive Surgery 108, no. 5 (October 2001): 1163–71. http://dx.doi.org/10.1097/00006534-200110000-00009.

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Hudson, Donald A., and Paul J. Skoll. "Single-Stage, Autologous Breast Restoration." Plastic and Reconstructive Surgery 108, no. 5 (October 2001): 1172–73. http://dx.doi.org/10.1097/00006534-200110000-00010.

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Zografos, George C., A. Louizos, G. Filipakis, and George Androulakis. "Cavity restoration following breast conservation surgery." Journal of Surgical Oncology 79, no. 1 (December 19, 2001): 72. http://dx.doi.org/10.1002/jso.10037.

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Tsamis, Dimitrios, I. Flessas, N. Michalopoulos, N. A. Papadopulos, and G. Zografos. "Breast restoration after complicated silicone injection." Hellenic Journal of Surgery 87, no. 3 (May 2015): 271–72. http://dx.doi.org/10.1007/s13126-015-0221-6.

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Borges, Lucas R., Lucio Azzari, Predrag R. Bakic, Andrew D. A. Maidment, Marcelo A. C. Vieira, and Alessandro Foi. "Restoration of low-dose digital breast tomosynthesis." Measurement Science and Technology 29, no. 6 (April 19, 2018): 064003. http://dx.doi.org/10.1088/1361-6501/aab2f6.

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Reaby, Linda L. "Breast restoration decision making: Enhancing the process." Cancer Nursing 21, no. 3 (June 1998): 196–204. http://dx.doi.org/10.1097/00002820-199806000-00007.

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Zikiryahodzhaev, A. D., and E. A. Rasskazova. "TWO-STAGE DELAYED RECONSTRUCTION IN PATIENTS WITH BREAST CANCER AFTER MASTECTOMY." Malignant tumours 8, no. 2 (July 11, 2018): 43–49. http://dx.doi.org/10.18027/2224-5057-2018-8-2-43-49.

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Delayed breast reconstruction after performing radical mastectomy for cancer is a surgical method of rehabilitation of patients. Breast reconstruction is performed to improve the quality of life of patients with breast cancer. Breast restoration using expander is used in women with a small breast size, as well as in patients who refuse to use patchwork techniques of breast restoration. In P. A. Herzen MORI 27 patients with a diagnosis of breast cancer was performed in delayed breast reconstruction after radical mastectomy.To achieve symmetry in 51,9 % of cases the operations were also performed on the healthy breast. During the observation period up to 4 years, no signs of progression of the underlying disease were found in this group.

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Busse, Brittany, Hakan Orbay, and David E. Sahar. "Sterile Acellular Dermal Collagen as a Treatment for Rippling Deformity of Breast." Case Reports in Surgery 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/876254.

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Prosthetic implants are frequently used for breast augmentation and breast reconstruction following mastectomy. Unfortunately, long-term aesthetic results of prosthetic breast restoration may be hindered by complications such as rippling, capsular contracture, and implant malposition. The advent of use of acellular dermal matrices has greatly improved the outcomes of prosthetic breast reconstruction. We describe a case of rippling deformity of breast that was treated using an acellular dermal matrix product, AlloMax. The patient presented with visible rippling of bilateral prosthetic breast implants as well as significant asymmetry of the breasts after multiple excisional biopsies for right breast ductal carcinoma in situ. A6×10 cm piece of AlloMax was placed on the medial aspect of each breast between the implant and the skin flap. Follow-up was performed at 1 week, 3 months, and 1 year following the procedure. The patient recovered well from the surgery and there were no complications. At her first postoperative follow-up the patient was extremely satisfied with the result. At her 3-month and 1-year follow-up she had no recurrence of her previous deformity and no new deformity.

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Li, Yi, Jiliang Qiu, Ting Pang, Zhixing Guo, Yonghui Su, Qingan Zeng, and Xuexia Zhang. "Restoration of Arpin suppresses aggressive phenotype of breast cancer cells." Biomedicine & Pharmacotherapy 92 (August 2017): 116–21. http://dx.doi.org/10.1016/j.biopha.2017.05.053.

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Ismagilov, A. Kh, and I. F. Kamaletdinov. "Comparative evaluation of the quality of life of patients depending of different inframammary fold creation techniques during a two-stage breast reconstruction." Tumors of female reproductive system 15, no. 1 (July 1, 2019): 12–18. http://dx.doi.org/10.17650/1994-4098-2019-15-1-12-18.

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Reconstruction of natural-looking breast involves the restoration of all the constituent elements that define the identity of a normal breast. The inframammary fold is one of the main anatomical elements that determine the shape of the breast. That is why the technical features of various methods of the inframammary fold reconstruction affect the final aesthetic result of the reconstructive surgery. This article considers a comparative evaluation of the quality of life and satisfaction with the reconstructed breast after the two-stage breast reconstruction with different inframammary fold creation techniques.

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Ali Khodja, N., H. Zeghlache, F. Benali, and O. Guani. "THE USE OF NEW TECHNOLOGIES IN THE RESTORATION AND CONSERVATION OF BUILT CULTURAL HERITAGE/ THE CASE OF THE STATUE OF FOUARA, SETIF, ALGERIA." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-2/W11 (May 4, 2019): 43–46. http://dx.doi.org/10.5194/isprs-archives-xlii-2-w11-43-2019.

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Abstract. The present paper deals with the techniques using the laser scanner survey in the restoration of the statue of Fouara in Setif, Algeria. This statue which is made of marble was realized by Francis de St Vidal in 1899 that represents a nymph which is a part of the fountain, publicly displayed in the center of the city's main plaza. On 18 December 2018, a man defaced the statue, removing the facial features and breasts with a hammer and chisel.As a matter of fact, the build cultural heritage in Algeria is in danger from attacks and reaction time deterioration with age. Following the day of the incident, our team has been called to use a previous scanner laser survey of the nymph that was stored in our cultural heritage monument database in order to help the restoration of the missing part of the nymph (the face and the breast. as matter of fact, the original laser scanning survey provided a helpful and accurate details to support the restoration of the nymph.

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Krämer, S., Friedrich M, and Kraft C. "Technique of Breast Reconstruction with Expander Implants after Mastectomy." Current Opinion in Gynecology and Obstetrics 1, no. 1 (December 11, 2018): 82–88. http://dx.doi.org/10.18314/cogo.v1i1.1275.

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The reconstruction of the female breast after mastectomy is an integral part of the surgical treatment of breast cancer nowadays. If it is necessary for oncologic reasons and if there are contraindications for breast conserving therapy, methods of breast reconstruction can contribute significantly to the restoration of physical integrity, including an improvement of life quality for the affected women. Besides an improvement or restoration of the physical image and of the self-esteem, breast reconstruction leads to a processing of an oncologically necessary mastectomy from a psychooncological and rehabilitative point of view. Alloplastic methods of breast reconstruction are the most common methods of reconstructing the female breast after mastectomy. In order to obtain optimal results from reconstruction, the use of textured, anatomically shaped expander-implant systems are recommended. After modified radical mastectomy a combined expander implant reconstruction can be indicated to reconstruct a smaller, non-ptotic breast after preforming stretching of the skin. This combined expander-implant reconstruction can be performed primarily during mastectomy as well as secondarily. If adjuvant therapy is necessary, especially in the case of radiation therapy, an implant or expander-implant reconstruction is relatively contraindicated because of an insufficiently high rate of complication. The patients need to be informed about the very often necessity of adapting mastopexy or reduction mastopexy of the contralateral breast and about possible autologous methods of reconstruction. In our opinion, adjuvant radiation therapy is a contraindication for alloplastic reconstruction because of an inacceptable complication rate, especially if compared to autologous reconstruction. Therefore, primary alloplastic reconstruction should be indicated very critically. When planning alloplastic or, of course, autologous breast reconstruction the overall oncological situation of the patient needs to be considered. To avoid prognostic or aesthetic disadvantages, the differential indication for the methods of breast reconstruction should ideally take place in specialized breast centres with experience in all methods of reconstruction.

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Pshenisnov, Kirill P. "Restoration of the shape, position, and skin of burn-damaged breast." Plastic &amp Reconstructive Surgery 100, no. 5 (October 1997): 1371. http://dx.doi.org/10.1097/00006534-199710000-00080.

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Weiss, Paul R., and Arthur G. Ship. "Restoration of Breast Contour with Autologous Tissue After Removal of Implants." Annals of Plastic Surgery 34, no. 3 (March 1995): 236–41. http://dx.doi.org/10.1097/00000637-199503000-00003.

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Ciftci, Ilhan, Tamer Sekmenli, Seda Ozbek, Mehtap Karamese, and Serdar Ugras. "Inframammarial Giant Fibroadenoma Removing and a Nipple-sparing Breast Reconstruction in an Adolescent: A Case Report." Prague Medical Report 116, no. 2 (2015): 161–66. http://dx.doi.org/10.14712/23362936.2015.54.

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Fibroadenomas are common, benign breast tumors that usually affect women in the second and third decade of life. Giant fibroadenomas often cause significant concern for the patient or family regarding malignant potential and altered breast development. Most fibroadenomas are benign. Local excision of small lesions through a circumareolar or inframammary incision rather than radical surgery is appropriate. Breast ultrasound represents the most commonly used imaging modality for the study of pediatric female breast masses and fibroadenomas. Detailed descriptions of the sonographic appearances of fibroadenomas in young girls are sparse. We believe that surgical treatment for the patient should include tumor extirpation and immediate restoration of breast appearance, minimizing visible scars, protection of the developing breast bud, nipple, and areola. This modality reduces psychosocial comorbidity.

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Girish, G. V., Nehi Sinha, K. Chakraborty, G. Bhattacharya, Nighat N. Kahn, and A. K. Sinha. "Restoration by aspirin of impaired plasma maspin level in human breast cancer." Acta Oncologica 45, no. 2 (January 2006): 184–87. http://dx.doi.org/10.1080/02841860500516584.

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Pshenisnov, Kirill P. "Restoration of the shape, position, and the skin of burn-damaged breast." Plastic & Reconstructive Surgery 102, no. 6 (November 1998): 2281. http://dx.doi.org/10.1097/00006534-199811000-00092.

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Zhou, Anna, Ivica Ducic, and Arash Momeni. "Sensory restoration of breast reconstruction – The search for the ideal approach continues." Journal of Surgical Oncology 118, no. 5 (October 2018): 780–92. http://dx.doi.org/10.1002/jso.25223.

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Kinoshita, S. K., and P. M. Azevedo Marques. "A method for edge restoration and breast region segmentation in noisy mammograms." International Congress Series 1268 (June 2004): 1350. http://dx.doi.org/10.1016/j.ics.2004.03.235.

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Feng, Zhi-Peng, Hong-Yi Xin, Ze-Wei Zhang, Chen-Guang Liu, Zheng Yang, Hua You, and Hong-Wu Xin. "Gut microbiota homeostasis restoration may become a novel therapy for breast cancer." Investigational New Drugs 39, no. 3 (January 17, 2021): 871–78. http://dx.doi.org/10.1007/s10637-021-01063-z.

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Bullock, M. "FOXO factors and breast cancer: outfoxing endocrine resistance." Endocrine-Related Cancer 23, no. 2 (November 26, 2015): R113—R130. http://dx.doi.org/10.1530/erc-15-0461.

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The majority of metastatic breast cancers cannot be cured and present a major public health problem worldwide. Approximately 70% of breast cancers express the estrogen receptor, and endocrine-based therapies have significantly improved patient outcomes. However, the development of endocrine resistance is extremely common. Understanding the molecular pathways that regulate the hormone sensitivity of breast cancer cells is important to improving the efficacy of endocrine therapy. It is becoming clearer that the PI3K–AKT–forkhead box O (FOXO) signaling axis is a key player in the hormone-independent growth of many breast cancers. Constitutive PI3K–AKT pathway activation, a driver of breast cancer growth, causes down-regulation of FOXO tumor suppressor functions. This review will summarize what is currently known about the role of FOXOs in endocrine-resistance mechanisms. It will also suggest potential therapeutic strategies for the restoration of normal FOXO transcriptional activity.

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S, Gopinathan. "Clinical Study about Latissimus Dorsi Based Breast Reconstruction at a Tertiary Health Centre in Mangalore, India." Journal of Evolution of Medical and Dental Sciences 10, no. 34 (August 23, 2021): 2905–9. http://dx.doi.org/10.14260/jemds/2021/592.

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BACKGROUND The most common cancer among urban Indian women is breast cancer. Mastectomy causes loss of body image and negatively impacts the quality of life. Restoration of body image is an important step for breast cancer survivors. Recent reconstruction options are autologous or implant-based reconstruction or combined approach. This present clinical study was done to describe about latissimus dorsi based breast reconstruction (BR) at a tertiary health centre. METHODS This retrospective study was conducted at a tertiary health care centre from Jun 2018 to Dec 2020. Eligible desiring patients’ divided into the small, medium and large breasts and were willing to undergo BR were taken up for surgery. Patients considered as suitable candidates were further assessed for the option of reconstruction by latissimus dorsi (LD) flap, LD flap with an implant. All the patients were fully explained about the procedure. RESULTS The total number of mastectomies were 158 and breast reconstruction was done in 45 patients, with a percentage of 29 %. In our study, majority of the patients (91.1 %) underwent immediate breast reconstruction. Reconstructive methods used in our study were autologous LD flap (64.4 %), LD flap with silicone implant (24.2 %) and pedicled transverse rectus abdominis myocutaneous (TRAM) flap (11.2 %) based on the size of the contralateral breast. The most common type of reconstruction in our study was the LD flap (64.4 %). CONCLUSIONS Immediate reconstruction of mastectomy defects was offered to all interested patients. Autologous or implant-based can be done safely with minimum morbidity. Latissimus dorsi flap-based breast reconstruction is a cost-effective, safe, reliable method at a tertiary health centre. KEY WORDS Breast Reconstruction, Flap, LD Flap, Implant

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Pinchasov, Y., I. Nir, and Zafrira Nitsan. "Muscle growth and composition in heavy and light breed chickens adapted to intermittent feeding." British Journal of Nutrition 61, no. 2 (March 1989): 245–56. http://dx.doi.org/10.1079/bjn19890113.

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1. The effect of intermittent feeding in chickens of heavy breed (HB; meat type) and light breed (LB; egg type) on skeletal muscle growth and composition was studied in adapted and non-adapted chickens.2. Food intake, relative to body-weight, was similar in both breeds but was higher in ad lib.-fed than in intermittently fed birds.3. On repletion days the relative growth rate was similar in both breeds, while on depletion the LB chickens lost more weight than the HB chickens. In both breeds, the relative growth was higher in the intermittently fed birds during days of food restoration than in those fed ad lib.4. The relative weight of the breast muscle was higher in HB birds than in LB birds, but deposition rate on the day of food restoration was similar in both breeds. This growth was more pronounced in chickens adapted to alternate feeding than in chickens exposed to this feeding regimen for one cycle.5. Protein concentration in breast muscle was not affected by age and was slightly higher in LB chickens than in HB chickens. Soluble protein was markedly reduced on days of repletion, and more at 46d than at 18d of age.6. The RNA:DNA ratio was higher in HB than in LB chickens, and lower on days of food deprivation than on days of food restoration. After repletion this ratio returned to the level of the ad lib.-fed chickens. While in LB chickens cell size (as estimated by DNA concentration) remained constant on repletion and depletion days, in the HB chickens it decreased.7. The rapid growth of breast muscle in HB chickens was attributed to the higher rate of protein synthesis (estimated by RNA:DNA ratio) compared with LB chickens. This may also explain why the breast muscle of LB chickens was less sensitive to intermittent feeding than that of HB chickens.

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Ebbesen, Saya H., Maurizio Scaltriti, Carl U. Bialucha, Natasha Morse, Edward R. Kastenhuber, Hannah Y. Wen, Lukas E. Dow, José Baselga, and Scott W. Lowe. "Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas." Proceedings of the National Academy of Sciences 113, no. 11 (February 29, 2016): 3030–35. http://dx.doi.org/10.1073/pnas.1523693113.

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Loss of the tumor suppressor gene PTEN is implicated in breast cancer progression and resistance to targeted therapies, and is thought to promote tumorigenesis by activating PI3K signaling. In a transgenic model of breast cancer, Pten suppression using a tetracycline-regulatable short hairpin (sh)RNA cooperates with human epidermal growth factor receptor 2 (HER2/neu), leading to aggressive and metastatic disease with elevated signaling through PI3K and, surprisingly, the mitogen-activated protein kinase (MAPK) pathway. Restoring Pten function is sufficient to down-regulate both PI3K and MAPK signaling and triggers dramatic tumor regression. Pharmacologic inhibition of MAPK signaling produces similar effects to Pten restoration, suggesting that the MAPK pathway contributes to the maintenance of advanced breast cancers harboring Pten loss.

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Savi, Federica, Irene Forno, Alice Faversani, Andrea Luciani, Sarah Caldiera, Stefano Gatti, Paolo Foa, et al. "miR-296/Scribble axis is deregulated in human breast cancer and miR-296 restoration reduces tumour growth in vivo." Clinical Science 127, no. 4 (April 10, 2014): 233–42. http://dx.doi.org/10.1042/cs20130580.

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miR-296-5p is a nodal miRNA deregulated in diverse human cancers. In the present study we show that miR-296-5p and its target Scribble play a role in breast carcinogenesis and metastatic dissemination. Furthermore, an miR-296-5p-based therapeutic approach hampers breast cancer tumour growth in vivo.

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Grishkevich, Viktor M. "Restoration of the shape, location and skin of the severe burn-damaged breast." Burns 35, no. 7 (November 2009): 1026–35. http://dx.doi.org/10.1016/j.burns.2008.12.008.

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Cai, Fenglin, Luhong Chen, Yuting Sun, Chunlan He, Deyuan Fu, and Jinhai Tang. "MiR-539 inhibits the malignant behavior of breast cancer cells by targeting SP1." Biochemistry and Cell Biology 98, no. 3 (June 2020): 426–33. http://dx.doi.org/10.1139/bcb-2019-0111.

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The aberrant expression of microRNAs (miRNAs) is involved in the initiation and progression of human cancers. In our study, we found that miR-539 was down-regulated in breast cancer tissues and cell lines. Decreased expression of miR-539 was significantly associated with lymph node metastasis in patients with breast cancer. Overexpression of miR-539 inhibited the proliferation and promoted apoptosis of breast cancer cells. Moreover, highly expressed miR-539 significantly suppressed the epithelial–mesenchymal transition (EMT) and sensitized cells to cisplatin treatment. Mechanistically, miR-539 was found to target the specificity protein 1 (SP1) and down-regulated the expression of SP1 in breast cancer cells. Knockdown of miR-539 consistently increased the expression of SP1. The expression of miR-539 in breast cancer tissues was negatively correlated with the expression of SP1. Restoration of SP1 significantly attenuated the inhibitory effect of miR-539 on the proliferation of breast cancer cells. Taken together, our results indicate that miR-539 has a tumor suppressive role in breast cancer via targeting SP1, suggesting miR-539 as a promising target for the diagnosis of breast cancer.

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Jakeman, Molly, Ranjeet Jeevan, Sasha C. Burn, and Sian Falder. "Neurosurgical transection of the breast: an unexpected extracranial complication of ventriculoperitoneal shunt insertion." Journal of Neurosurgery: Pediatrics 20, no. 6 (December 2017): 517–20. http://dx.doi.org/10.3171/2017.7.peds16708.

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Ventriculoperitoneal (VP) shunt placement is among the most common surgical procedures undertaken by neurosurgeons. Complications arising from the thoracic portion of the shunt are relatively rare in comparison with those of the intraventricular and peritoneal portions. Disruption of primary breast development following VP shunt placement has not previously been reported. The authors describe the case of a 15-year-old girl referred to the plastic surgery department with a significant right breast deformity and associated asymmetry following VP shunt placement performed during the neonatal period. The calcified shunt was excised and the breast deformity was corrected surgically through multiple scar tissue releases and restoration of the normal breast parenchymal anatomy via a minimally invasive approach, resulting in an excellent aesthetic outcome.This case highlights the potential for injury to occult breast tissue in pediatric patients undergoing VP shunt placement, which can impair subsequent cosmesis and quality of life.

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Sharobaro, V. I., A. A. Baeva, and N. V. Mokshina. "Algorithm of oNe-stAge correctioN oF breAst Asymmetry iN PAtieNts with hyPomAstiA." Journal of Clinical Practice 7, no. 2 (June 15, 2016): 3–14. http://dx.doi.org/10.17816/clinpract723-14.

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We analyzed the results of one-stage correction of the asymmetry of mammary glands in 51 patients with a diagnosis of hypomastia. On the basis of obtained results the algorithm of one-stage restoration of symmetry at the given category of patients, based on the type and severity of the asymmetry was developed, which contributes to the achievement of good aesthetic results in 94.1% of cases.

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Nel, Ivonne, Erik W. Morawetz, Dimitrij Tschodu, Josef A. Käs, and Bahriye Aktas. "The Mechanical Fingerprint of Circulating Tumor Cells (CTCs) in Breast Cancer Patients." Cancers 13, no. 5 (March 5, 2021): 1119. http://dx.doi.org/10.3390/cancers13051119.

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Circulating tumor cells (CTCs) are a potential predictive surrogate marker for disease monitoring. Due to the sparse knowledge about their phenotype and its changes during cancer progression and treatment response, CTC isolation remains challenging. Here we focused on the mechanical characterization of circulating non-hematopoietic cells from breast cancer patients to evaluate its utility for CTC detection. For proof of premise, we used healthy peripheral blood mononuclear cells (PBMCs), human MDA-MB 231 breast cancer cells and human HL-60 leukemia cells to create a CTC model system. For translational experiments CD45 negative cells—possible CTCs—were isolated from blood samples of patients with mamma carcinoma. Cells were mechanically characterized in the optical stretcher (OS). Active and passive cell mechanical data were related with physiological descriptors by a random forest (RF) classifier to identify cell type specific properties. Cancer cells were well distinguishable from PBMC in cell line tests. Analysis of clinical samples revealed that in PBMC the elliptic deformation was significantly increased compared to non-hematopoietic cells. Interestingly, non-hematopoietic cells showed significantly higher shape restoration. Based on Kelvin–Voigt modeling, the RF algorithm revealed that elliptic deformation and shape restoration were crucial parameters and that the OS discriminated non-hematopoietic cells from PBMC with an accuracy of 0.69, a sensitivity of 0.74, and specificity of 0.63. The CD45 negative cell population in the blood of breast cancer patients is mechanically distinguishable from healthy PBMC. Together with cell morphology, the mechanical fingerprint might be an appropriate tool for marker-free CTC detection.

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Padmanabhan, Regina, Hadeel Shafeeq Kheraldine, Nader Meskin, Semir Vranic, and Ala-Eddin Al Moustafa. "Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models." Cancers 12, no. 3 (March 10, 2020): 636. http://dx.doi.org/10.3390/cancers12030636.

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Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2+) and triple-negative breast cancers. Therapies targeting HER2 receptors have significantly improved HER2+ breast cancer patient outcomes. However, several recent studies have pointed out the deficiency of existing treatment protocols in combatting disease relapse and improving response rates to treatment. Overriding the inherent actions of the immune system to detect and annihilate cancer via the immune checkpoint pathways is one of the important hallmarks of cancer. Thus, restoration of these pathways by various means of immunomodulation has shown beneficial effects in the management of various types of cancers, including breast. We herein review the recent progress in the management of HER2+ breast cancer via HER2-targeted therapies, and its association with the programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) axis. In order to link research in the areas of medicine and mathematics and point out specific opportunities for providing efficient theoretical analysis related to HER2+ breast cancer management, we also review mathematical models pertaining to the dynamics of HER2+ breast cancer and immune checkpoint inhibitors.

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Sheng, Zejuan, Wenping Sun, Elizabeth Smith, Cynthia Cohen, Zeqi Sheng, and Xiang-Xi Xu. "Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells." Oncogene 19, no. 42 (October 2000): 4847–54. http://dx.doi.org/10.1038/sj.onc.1203853.

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Batisteli, Augusto, Marcel Tanaka, and Andréa Souza. "Bird Functional Traits Respond to Forest Structure in Riparian Areas Undergoing Active Restoration." Diversity 10, no. 3 (August 14, 2018): 90. http://dx.doi.org/10.3390/d10030090.

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Monitoring wildlife responses is essential to assess restoration projects. Birds are widely used as bioindicators of ecosystem restoration, but most studies use only taxonomic descriptors to compare categories of reference and restoring sites. Here, we used forest structure as a continuous predictor variable to evaluate avifaunal taxonomic and functional indicators in riparian forest reference and restoration sites on southeastern Brazil. Reference sites were riparian forest remnants, and restoration sites were pasture before seedling reintroduction. Forest structure variables (mean tree height, canopy depth, mean diameter at breast height, basal area, tree layering, tree density, and grass cover) were reduced into two axes using a Principal Component Analysis (PCA), Forest Axis 1 (tree biomass vs. grass cover) and Forest Axis 2 (canopy depth vs. tree density). Bird species were classified in relation to five functional categories (i.e., diet, foraging stratum, nest height, cavity dependence for nesting, and forest dependence). Forest Axis 1 influenced the functional diversity of bird assemblages and the relative abundance within levels of each functional category (except for nest height). The relative abundance of all functional categories combined was also affected by Forest Axis 2. Therefore, forest structure affected the predominant functional traits of bird species in riparian sites under restoration. Sites with higher tree biomass were the richest, with canopy birds that were insectivores and frugivores of high forest dependence, whereas more open sites were associated with birds of low forest dependence and ground-foraging insectivores. Forest structures of similar-aged sites were strongly variable, due to natural and anthropic disturbances, so restoration age was a poor indicator of forest development. These unpredictable disturbances can change the development of sites under restoration, so that forest structure can be a better descriptor of the trajectory of these ecosystems.

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Deshmukh, Sachin Kumar, Sanjeev Kumar Srivastava, Haseeb Zubair, Mohammad Aslam Khan, Ajay Pratap Singh, and Seema Singh. "Resistin Induces LIN28A-Mediated Let-7a Repression in Breast Cancer Cells Leading to IL-6 and STAT3 Upregulation." Cancers 13, no. 18 (September 7, 2021): 4498. http://dx.doi.org/10.3390/cancers13184498.

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Downregulation of the Let-7 family of microRNAs (miRNAs) has been reported in several cancers, including breast malignancy; however, underlying mechanisms are not completely understood. Resistin is an important component of the tumor microenvironment, having a functional impact on the tumor cell phenotypes. Here, we examined the role of resistin in the regulation of Let-7 miRNAs and studied its downstream consequences. We found that resistin treatment led to the reduced expression of Let-7 family miRNAs in breast cancer (BC) cells, with the highest downregulation reported for Let-7a. Furthermore, resistin induced the expression of LIN28A, and its silencing abrogated resistin-mediated Let-7a suppression. Let-7a restoration or LIN28A silencing abolished the resistin-induced growth, clonogenicity, and sphere-forming ability of BC cells. Restoration of Let-7a also suppressed the resistin-induced expression of genes associated with growth, survival, and stemness. Pathway analysis suggested STAT3 as a putative central node associated with Let-7a-mediated gene regulation. In silico analysis identified STAT3 and its upstream modifier, IL-6, as putative Let-7a gene targets, which were later confirmed by 3′UTR-reporter assays. Together, our findings demonstrate a novel resistin/LIN28A/Let-7a/IL-6/STAT3 signaling axis supporting the growth and stemness of BC cells.

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Ivashkov, Vladimir. "BRANT (BREAST RECONSTRUCTION AND NODE TRANSPLANTATION) - A ONE-STAGE TRANSPLANTATION OF INGUINAL LYMPH NODES AND DELAYED BREAST RECONSTRUCTION. MODERN CONCEPT IN RECONSTRUCTIVE MICROSURGERY OF LYMPHATIC SYSTEM LESIONS." Problems in oncology 63, no. 6 (June 1, 2017): 867–75. http://dx.doi.org/10.37469/0507-3758-2017-63-6-867-875.

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Secondary lymphedema is one of the common complications after complex treatment of breast cancer. One of the promising methods of treatment of lymphatic edema at the moment is microsurgical autotransplantation of inguinal lymph nodes. Only one method for treating lymphatic edema with a one-stage breast reconstruction was the concept of TBAR (Total Breast Anatomy Restoration), which implies the use of an inguinal lymphatic flap in the unfree variant - with the inclusion of its DIEP flap for delayed breast reconstruction. Cons - the concept is limited to using only the DIEP flap. A patient suffering from lymphatic edema and in need of breast reconstruction may not have enough tissue on the anterior abdominal wall. Therefore, our goal was to create an alternative concept, not tied to a single flap. BRANT (Breast Reconstruction And Node Transplantation) means microsurgical autotransplantation of the inguinal lymph flap into the axillary region and the use of any of the available flaps, to restore anatomical structures and to replenish the volume of the breast. The proposed method allows achieving the following results: for the minimal amount of surgical interventions an attractive type of breast is restored and good results are achieved in the treatment of lymphatic edema of the hand.

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Wei, Yuxian, Hongyan Huang, Zhu Qiu, Hongzhong Li, Jinxiang Tan, Guosheng Ren, and Xiaoyi Wang. "NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4938473.

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Recent studies suggest that nucleotide-binding domain leucine-rich repeat protein 1 (NLRP1) is a pivotal factor in the inflammatory process. However, the role of NLRP1 in breast cancer pathogenesis remains unclear. The aim of this study was to examine the expression and function of NLRP1 in breast cancer. We found that NLRP1 was widely expressed in 83% (60/72) of primary breast cancer tissue. NLRP1 expression level was higher in primary breast cancer tissue than in adjacent noncancerous tissue (p<0.001) and NLRP1 expression was associated with lymph node metastasis (p=0.003), TNM stage (p=0.003), and Ki-67 levels (p<0.001). Overexpression of NLRP1 in the breast cancer cell line MCF-7 promotes proliferation, migration, invasion, and tumorigenicity in nude mice. Restoration of NLRP1 expression resulted in the EMT occurrence that downregulation of epithelial marker E-cadherin and upregulation mesenchymal marker vimentin, C-myc, MMP-9, and snail. In summary, NLRP1 promotes cell line MCF-7 the proliferation, migration, and invasion through inducing EMT.

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Rogayah, Rogayah, Waliya Rahmawanti, and Nur Azizah. "Colour-Based Extraction Methods for the Classification of Breast Milk (ASI)." CCIT Journal 14, no. 1 (February 10, 2021): 21–27. http://dx.doi.org/10.33050/ccit.v14i1.966.

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The development of cellular devices makes accessing information in the form of text or images more easier. In line with the growing field of computer vision, various processes in image/image processing continue to increase. Image processing can be done by increasing image quality (image enhancement) and image recovery (image restoration). Feature extraction is divided into three types, namely feature form extraction, texture feature extraction, and color feature extraction. The application of color-based feature extraction methods has been widely used by researchers in the process of classification of various objects. This paper aims to review the technology that can be applied to image processing in a CBIR system with the object of breast milk so that it can measure the quality of breast milk based on its color.

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Zhang, Guochen, Junlan Wang, Ruilin Zheng, Beibei Song, Li Huang, Yujiang Liu, Yating Hao, and Xiangdong Bai. "MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382092701. http://dx.doi.org/10.1177/1533033820927011.

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Triple-negative breast cancer shows worse outcome compared with other subtypes of breast cancer. The discovery of dysregulated microRNAs and their roles in the progression of triple-negative breast cancer provide novel strategies for the treatment of patients with triple-negative breast cancer. In this study, we identified the significant reduction of miR-133 in triple-negative breast cancer tissues and cell lines. Ectopic overexpression of miR-133 suppressed the proliferation, colony formation, and upregulated the apoptosis of triple-negative breast cancer cells. Mechanism study revealed that the YES Proto-Oncogene 1 was a target of miR-133. miR-133 bound the 3′-untranslated region of YES Proto-Oncogene 1 and decreased the level of YES Proto-Oncogene 1 in triple-negative breast cancer cells. Consistent with miR-133 downregulation, YES1 was significantly increased in triple-negative breast cancer, which was inversely correlated with the level of miR-133. Restoration of YES Proto-Oncogene 1 attenuated the inhibitory effects of miR-133 on the proliferation and colony formation of triple-negative breast cancer cells. Consistent with the decreased expression of YES Proto-Oncogene 1, overexpression of miR-133 suppressed the phosphorylation of YAP1 in triple-negative breast cancer cells. Our results provided novel evidence for the role of miR-133/YES1 axis in the development of triple-negative breast cancer, which indicated miR-133 might be a potential therapeutic strategy for triple-negative breast cancer.

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Irshad, Iram, and Pegah Varamini. "Different Targeting Strategies for Treating Breast Cancer Bone Metastases." Current Pharmaceutical Design 24, no. 28 (December 7, 2018): 3320–31. http://dx.doi.org/10.2174/1381612824666180619165728.

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Background: Breast cancer is the most frequently diagnosed malignancy in women worldwide. Breast cancer tends to metastasize to bone. Around 70% of the breast cancer patients eventually develop bone metastasis. After the bone invasion, metastatic cells disrupt the balance between osteoblastic and osteoclastic activities, leading to skeletal complications, characterized by pain and pathological fractures and hence worsening the patient's quality of life. Once tumor invades the bone, it is hard to treat it with, the so-far available treatments options (e.g. bisphosphonates and denosumab). Bone metastasis should be essentially controlled, in cancer treatment and there is a strong need to explore new, more efficient therapeutic targets. This review discusses the bone physiological processes and the recent advances in exploring different pathways involved in bone metastasis. Furthermore, some novel treatment options, which are under preclinical and clinical investigations, are highlighted. Conclusion: A deeper understanding of these metastatic pathways can provide oncology researchers with novel avenues for treating bone metastasis, one of the main challenges to cure breast cancer. The restoration of healthy bone environment will not only improve the patient's quality of life but also reduces the tumor burden.

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Zhu, Lin, Fengchun Wang, Wenhui Fan, Zhi Jin, Chao Teng, and Jianxin Zhang. "lncRNA NEAT1 promotes the Taxol resistance of breast cancer via sponging the miR-23a-3p-FOXA1 axis." Acta Biochimica et Biophysica Sinica 53, no. 9 (July 30, 2021): 1198–206. http://dx.doi.org/10.1093/abbs/gmab098.

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Abstract Breast cancer is the most prevalent malignancy among women worldwide. Paclitaxel (Taxol) is a widely applied chemotherapeutic agent against breast cancer. Although Taxol therapy has achieved improvements recently, development of chemoresistance of breast cancer patients is a major obstacle, leading to therapeutic failure. Long non-coding RNAs (lncRNAs) play pivotal roles in tumorigenesis and progresses of breast cancer. However, the biological roles and molecular targets of lncRNA NEAT1 in Taxol-resistant breast cancer remain unclear. Here, we report that NEAT1 is significantly upregulated in breast tumors and cell lines. In addition, silencing NEAT1 effectively sensitizes breast cancer cells to Taxol. Bioinformatical analysis and luciferase assay demonstrated that miR-23a-3p could be sponged and downregulated by NEAT1. We demonstrated that miR-23a-3p was downregulated and functioned as a tumor suppressor in breast cancer. Furthermore, in the established Taxol-resistant MDA-MB-231 breast cancer cell line, we detected significantly increased NEAT1 expression and downregulated miR-23a-3p expression. Importantly, FOXA1 was identified and validated as a direct target of miR-23a-3p in breast cancer cells. Rescue experiments demonstrated that the restoration of miR-23a-3p in NEAT1-overexpressing Taxol-resistant breast cancer cells successfully overcame the NEAT1-promoted Taxol resistance. Taken together, our results revealed the clinical roles and molecular mechanisms for the NEAT1-mediated chemoresistance, providing new insights into the development of non-coding RNA-based therapeutic strategies for enhancing the anti-cancer effects of traditional chemotherapeutic drugs.

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Moiseenko, Fedor V., Nikita Volkov, Alexey Bogdanov, Michael Dubina, and Vladimir Moiseyenko. "Resistance mechanisms to drug therapy in breast cancer and other solid tumors: An opinion." F1000Research 6 (March 17, 2017): 288. http://dx.doi.org/10.12688/f1000research.10992.1.

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Cancer is an important contributor to mortality worldwide. Breast cancer is the most common solid tumor in women. Despite numerous drug combinations and regimens, all patients with advanced breast cancer, similarly to other solid tumors, inevitably develop resistance to treatment. Identified mechanisms of resistance could be classified into intra- and extracellular mechanisms. Intracellular mechanisms include drug metabolism and efflux, target modulations and damage restoration. Extracellular mechanisms might be attributed to the crosstalk between tumor cells and environmental factors. However, current knowledge concerning resistance mechanisms cannot completely explain the phenomenon of multi-drug resistance, which occurs in the vast majority of patients treated with chemotherapy. In this opinion article, we investigate the role of these factors in the development of drug-resistance.

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Pellecchia, Simona, Romina Sepe, Antonella Federico, Mariella Cuomo, Sara Carmela Credendino, Pasquale Pisapia, Claudio Bellevicine, et al. "The Metallophosphoesterase-Domain-Containing Protein 2 (MPPED2) Gene Acts as Tumor Suppressor in Breast Cancer." Cancers 11, no. 6 (June 8, 2019): 797. http://dx.doi.org/10.3390/cancers11060797.

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Background: We have recently reported the downregulation of the Metallophosphoesterase-domain-containing protein 2 (MPPED2) gene and its cognate long non-coding RNA, MPPED2-AS1, in papillary thyroid carcinomas. Functional studies supported a tumor suppressor role of both these genes in thyroid carcinogenesis. We then decided to investigate their role in breast carcinogenesis. Methods: In order to verify MPPED2 expression, 45 human breast carcinoma samples have been investigated by quantitative real-time polymerase chain reaction (qRT-PCR). Then, MPPED2 has been transfected in several human breast carcinoma cell lines, analyzing its role in cell proliferation, migration and invasion. To study the regulation of MPPED2 expression the methylation of its promoter was investigated by targeted bisulfite sequencing. Results: MPPED2 expression was decreased in breast cancer samples, and this was confirmed by the analysis of data available in The Cancer Genome Atlas (TCGA). Interestingly, the hypermethylation of MPPED2 promoter likely accounted for its downregulation in breast cancer. Additionally, MPPED2-AS1 was also found downregulated in breast cancer tissues and, intriguingly, its expression decreased the hypermethylation of the MPPED2 promoter by inhibiting DNA methyltransferase 1 (DNMT1). Furthermore, the restoration of MPPED2 expression reduced cell proliferation, migration and invasion capability of breast carcinoma cell lines. Conclusion: Taken together, these results propose MPPED2 downregulation as a critical event in breast carcinogenesis.

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Bayliss, Jill, Amy Hilger, Prakash Vishnu, Kathleen Diehl, and Dorraya El-Ashry. "Reversal of the Estrogen Receptor–Negative Phenotype in Breast Cancer and Restoration of Antiestrogen Response." Clinical Cancer Research 13, no. 23 (December 1, 2007): 7029–36. http://dx.doi.org/10.1158/1078-0432.ccr-07-0587.

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Zhu, Kun, Kang Li, Haonan Wang, Li Kang, Chengxue Dang, and Yong Zhang. "Discovery of Glabridin as Potent Inhibitor of Epidermal Growth Factor Receptor in SK-BR-3 Cell." Pharmacology 104, no. 3-4 (2019): 113–25. http://dx.doi.org/10.1159/000496798.

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The breast cancer is the leading cause of death in women. Therefore, objective of the present study was to examine the antibreast cancer effect of glabridin (GBN) and to evaluate its mechanism of action. In this study, we have demonstrated that GBN causes reduction of cellular viability of human breast cancer SK-BR-3 in MTT assay. Results from Hoechst 33342 and propidium iodide staining assay suggested that GBN causes significant enhancement in the apoptosis. At the molecular level, in western blot analysis, GBN causes significant increase in c-PARP and c-caspases 3, 8, and 9 concentrations in a dose-dependent manner in breast cancer cells. The GBN further showed reduced level of p-epidermal growth factor receptor, p-AKT, p-ERK1/2, and cyclin D1 as the concentration rose in treated cells. Subsequent to this, GBN showed beneficial effect in 7,12-dimethylbenz[a]anthracene-induced breast cancer in experimental mice as confirmed by increase in body weight, reduction in tumor volume, oxidative stress, and dose-dependent restoration of all tested enzymes (phase I and II) in the treated group. GBN may, thus, play a protective role as an antibreast cancer drug for the prevention of breast cancer.

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Peterson, Steven W., and Howard A. Tobin. "B Mastopexy: Versatility and 5-Year Experience." American Journal of Cosmetic Surgery 24, no. 2 (June 2007): 85–90. http://dx.doi.org/10.1177/074880680702400205.

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Introduction: Many women are searching for restoration of a younger outward physical appearance. Mastopexy with or without augmentation may help improve or restore a woman's breast shape at the price of scars on the breast. We describe our experience with the versatility and improved aesthetic result using the B mastopexy technique, which provides a natural-appearing breast contour with less scarring. Materials and Methods: A retrospective review was performed on 40 patients who underwent B-type mastopexy from June 2000 through August 2005. Our technique is described in detail including our approach when simultaneous augmentation is performed. Patients undergoing simultaneous augmentation to give additional fill to the breast typically received an implant size ranging from 240 mL to 300 mL. Results: B mastopexy was performed on 40 patients with simultaneous augmentation performed in 27 patients. There were no complications, and only 1 patient underwent scar revision. All patients were satisfied with final outcome. Conclusion: B mastopexy provides an approach to restoring a naturally appearing breast contour and a more youthful look when augmentation is performed simultaneously. The versatility and limited scar makes this our procedure of choice.

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Unruh, Anita M., Nancy Smith, and Cynthia Scammell. "The Occupation of Gardening in Life-Threatening Illness: A Qualitative Pilot Project." Canadian Journal of Occupational Therapy 67, no. 1 (February 2000): 70–77. http://dx.doi.org/10.1177/000841740006700110.

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This qualitative pilot study was completed as an exploratory study of the meaning of gardening using attention restoration theory. Three women with breast cancer who garden for leisure were recruited from a cancer support group. Each participant was interviewed at her home on two occasions. To complement the qualitative data, participants also completed the Perceived Restorativeness Scale (PRS) (Hartig, Korpela, Evans, & Garling, 1996). The interviews revealed six major themes some of which were concerned with the interactions between the gardener and the garden, and others which focused on gardening within the context of having cancer. The qualitative and quantitative outcomes supported the perspective of attention restoration theory. Spirituality was interwoven throughout the comments of two participants but was less important for one participant. The implications of this study for practice and future research are discussed.

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Zeng, Peng, Shengnan Sun, Rui Li, Zhi-Xiong Xiao, and Hu Chen. "HER2 Upregulates ATF4 to Promote Cell Migration via Activation of ZEB1 and Downregulation of E-Cadherin." International Journal of Molecular Sciences 20, no. 9 (May 6, 2019): 2223. http://dx.doi.org/10.3390/ijms20092223.

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HER2 (human epidermal growth factor receptor 2) activation is critical in breast cancer development. HER2 promotes cell proliferation, angiogenesis, survival, and metastasis by activation of PI3K/Akt, Ras/MEK/ERK, and JAK/STAT pathways. However, beyond these signaling molecules, the key proteins underlining HER2-mediated metastasis remain elusive. ATF4 (Activating transcription factor 4), a critical regulator in unfolded protein response (UPR), is implicated in cell migration and tumor metastasis. In this study, we demonstrate that HER2 upregulated ATF4 expression at both mRNA and protein levels, resulting in cell migration increased. In addition, ATF4 upregulated ZEB1 (Zinc finger E-box-binding homeobox 1) and suppressed E-cadherin expression resulting in promoting cell migration. Restoration of E-cadherin expression effectively inhibited HER2- or ATF4-mediated cell migration. In addition, upregulated expression of ATF4 was found in HER2-positive breast cancer specimens. Together, this study demonstrates that ATF4-ZEB1 is important for HER2-mediated cell migration and suggests that ATF4-ZEB1 may be potential therapeutic targets for breast cancer metastasis.

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Chandran, Elias A., and Ian Kennedy. "Case Report: Sustained Complete Response to PI3K Inhibition in a Patient with Metastatic Breast Cancer Harboring PIK3CA, NF1, and CDH1 Mutations." Journal of Immunotherapy and Precision Oncology 3, no. 3 (May 18, 2020): 133–36. http://dx.doi.org/10.36401/jipo-20-5.

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ABSTRACT PIK3CA mutations resulting in disinhibition of the phosphoinositide 3-kinase (PI3K) pathway are present in approximately a third of estrogen receptor (ER)-positive breast cancer. Recent clinical trials of PI3K inhibition in PIK3CA-mutated metastatic breast cancer have shown improvement in progression-free survival of up to 11 months. We report a 68-year-old woman with metastatic ER-positive breast cancer with PIK3CA mutation who despite having disease progression after four lines of endocrine therapy (ET) attained a complete response (CR) after subsequent addition of a PI3K inhibitor. Remarkably, her CR is still maintained at 5 years. We believe this may be due to the co-occurrence of an NF1 mutation, which increases sensitivity to PI3K inhibition. Our case demonstrates restoration of sensitivity to ET by additional inhibition of PI3K, which resulted in exceptional disease response, far exceeding the expected duration. Hence, we believe that PI3K inhibition in addition to ET should be considered in patients with simultaneous PIK3CA and NF1 mutations.

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Journal articles on the topic 'Breast restoration'

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