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Books on the topic 'Breast cancer, pregnancy, chemotherapy, radiotherapy'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

Veronique, Benk, and Canadian Coordinating Office for Health Technology Assessment., eds. Impact of radiation wait times on risk of local recurrence of breast cancer: Early stage cancer with no chemotherapy. Ottawa: Canadian Coordinating Office for Health Technology Assessment, 2004.

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2

1955-, Jatoi Ismail, and Singletary S. Eva, eds. Breast cancer: New concepts in management. Philadelphia: W.B. Saunders Co., 2003.

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3

Singletary, S. Eva. Breast cancer: Myths & facts : what you need to know. 3rd ed. Manhasset, NY: Oncology Pub. Group of CMP Healthcare Media, 2004.

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4

Breast cancer Mardi Gras: Surviving the emotional hurricane and showing my boobs to strangers. Bloomington, IN: AuthorHouse, 2013.

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5

Breast Cancer. Springer, 2012.

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6

Singletary, S. Eva. Breast Cancer. Springer London, Limited, 2012.

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7

A Journey through Cancer: A Woman Doctor's Personal Experience with Breast Cancer. iUniverse, Inc., 2004.

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8

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, Gareth Morris-Stiff, and Madhumita Bhattacharyya. Breast cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0014_update_001.

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Thoracic cancer examines the epidemiology, aetiology, and role of screening and prevention in the reduction of deaths from lung cancer, the majority caused by cigarette smoking. The pathology and genetics of lung cancer, with particular note of the driver mutations, are followed by the symptoms and signs of the disease. Appropriate investigations are described to stage the tumour. The optimum treatment for localised non-small cell lung cancer (NSCLC) is surgical resection, followed in some cases by adjuvant chemotherapy. However, most cases present with disease too advanced for surgery, and for these chemotherapy and radiotherapy are appropriate. Metastatic NSCLC can be treated with platinum based doublet chemotherapy with modest palliative benefits. Metastatic NSCLC with specific driver mutations are amenable to control by targeted therapy. Locally advanced NSCLC is often treated with similar chemotherapy and radiotherapy, ideally administered concurrently, to achieve symptom relief but also improved survival rates. Short course simple radiotherapy offers symptom relief in patients not fit for chemotherapy. Patients with localised NSCLC who are not fit for surgery, may benefit from radical radiotherapy, particularly stereotactic radiotherapy. Small cell lung cancer (SCLC) is characterised by almost universal systemic spread, so that surgery is rarely appropriate. Staging is similar to NSCLC, and chemotherapy is the mainstay of treatment, usually cisplatin or carboplatin combined with etoposide. When possible, this is combined with concurrent thoracic irradiation covering all radiological sites of disease. Prophylactic cranial irradiation reduces the risk of CNS disease. Malignant pleural mesothelioma is caused by occupational asbestos exposure. Symptoms and signs, investigation and staging, and management are discussed. Thymic tumours, their pathology, presenting symptoms including paraneoplastic syndromes, investigation, staging and treatment are reviewed.

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9

Adjuvant therapy for breast cancer. Cary, NC: Oxford University Press, 2001.

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10

Adjuvant Breast Cancer Treatment. Springer, 2009.

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11

National Institute of Health Consensus Development Conference: Adjuvant therapy for breast cancer. Bethesda, MD: National Cancer Institute, 2001.

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12

The National Institutes of Health Consensus Development Conference: Adjuvant therapy for breast cancer : Bethesda, Maryland, November 1-3, 2000 (Journal of the National Cancer Institute). National Institutes of Health, 2001.

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13

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, Gareth Morris-Stiff, and Amen Sibtain. Colorectal cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0015_update_001.

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Breast cancer reviews the epidemiology and aetiology of this malignancy, with particular attention to the genetics underlying familial breast cancer, its pathology along with its receptors, oestrogen receptor (ER), the growth factor receptor HER2, and epidermal growth factor receptor (EGFR), and the bearing these have on treatment and prognosis. The benefits of breast cancer screening in the population and families at higher risk are discussed. Presenting symptoms and signs are followed by investigation including examination, bilateral mammography, and core biopsy of suspicious lesions. Management of non-invasive in situ disease is considered. Invasive breast cancer is staged according to TNM guidelines. Early breast cancer is defined, managed frequently by breast conserving surgery and sentinel node biopsy from the axilla. A positive sentinel node biopsy requires clearance of the axilla. Larger lesions may require mastectomy. Breast radiotherapy is indicated after breast conserving surgery. Following surgery, the risk of systemic micrometastatic disease is estimated from the primary size, lymph node spread, and tumour grade. Adjuvant chemotherapy improves treatment outcome in all but very good prognosis premenopausal breast cancer, and intermediate or poor prognosis postmenopausal breast cancer. This is combined with trastuzumab in HER2 positive disease. Adjuvant endocrine therapy is recommended for all ER positive breast cancer, tamoxifen in premenopausal, aromatase inhibitors in postmenopausal women. Neoadjuvant chemotherapy may be used in large operable breast cancers to facilitate breast conserving surgery. Locally advanced breast cancer is defined, its high risk of metastatic disease requiring full staging before treatment. Systemic therapy is often best first treatment, according to receptor profile. Metastatic breast cancer although incurable can be controlled for years using endocrine therapy, chemotherapy, trastuzumab, palliative radiotherapy, and bisphosphonates as appropriate. Male breast cancer is uncommon, but management similar.

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14

Smyth, Dion. Breast surgery. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642663.003.0027.

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Breast surgery is usually the principal and primary treatment of malignant diseases of the breast. It may now sometimes follow neo-adjuvant therapies, such as chemotherapy or radiotherapy, but, for most patients with breast cancer, their disease pathway will include some form of surgery for either diagnostic evaluation, local control of the disease, prophylactic or risk-reducing reasons, or reconstructive rehabilitation. Nevertheless, this treatment modality, whilst contributing to increasing survival and other improved outcomes, is not without some physical and psychosocial morbidity. This chapter presents an overview of breast surgery, related primarily to cancer, and describes the clinical context of this modality in modern cancer care and some of the key considerations of caring for patients requiring and receiving this form of treatment.

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15

Kulkarni, Kunal, James Harrison, Mohamed Baguneid, and Bernard Prendergast, eds. Breast surgery. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198729426.003.0021.

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Breast cancer trials started in the 1930s and have made major contributions to the field of evidence-based medicine and the management of breast cancer. In the United States, the National Surgical and Adjuvant Breast Project (NSABP), established in 1957, has been responsible for many pivotal breast cancer trials in breast cancer surgery, radiotherapy, chemotherapy, and hormone therapy. The Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) started in 1985, with the aim of sharing data from high-quality randomized trials worldwide to promote high-quality meta-analyses. Increasingly, breast cancer is being recognized not as one single pathology, but as a disease with a biology and behaviour that is individual to each patient. This chapter discusses trials which have been pivotal in this dynamic time for breast cancer research and which have led the way in personalized therapies for cancer patients.

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16

Cutter, David, and Martin Scott-Brown. Treatment of cancer. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0325.

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The variety of conditions that are considered to be ‘cancer’ is extremely wide, with marked variation in the management approach from disease to disease. A common feature in the management of malignant conditions, however, is the involvement of a wide range of medical professionals at different stages of the patient pathway. This commonly includes physicians, surgeons, radiologists, pathologists, medical oncologists, radiation oncologists, and specialist nurses, as well as a plethora of other allied disciplines. As such, a practice that has been widely adopted is to work as a multidisciplinary team (MDT), with regular meetings to decide the appropriate treatment for each patient with a cancer diagnosis, on an individual and case-by-case basis. The main treatment modalities for the treatment of cancer are surgery, radiotherapy, and chemotherapy. While these are often combined to form a multimodality therapy, they are all, in isolation, potentially radical (curative) therapies for certain conditions. For example, surgery (in the case of a Stage I colon adenocarcinoma), radiotherapy (in the case of early laryngeal squamous cell carcinoma), and chemotherapy (in the case of acute lymphoblastic leukaemia) are all curative as single-modality treatments. It is commonly the case, however, for a patient to require more than one mode of therapy to achieve the best outcome, for example a combination of surgery, chemotherapy, and radiotherapy for early breast cancer. It can also be the case that two or more different management strategies are thought to give equivalent oncological results, for example surgery or radiotherapy for early prostate cancer. In this situation, the MDT and the patient need to decide on the ‘best’ management plan for the individual, based on their personal and professional opinions and on the differing toxicity profiles of the alternate treatments.

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17

Watson, Max, Caroline Lucas, Andrew Hoy, and Jo Wells. Oncology and palliative care. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199234356.003.0011.

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This chapter covers organization of cancer care, clinical trials, oncological surgery, chemotherapy, cytotoxic drugs, radiotherapy, types of radiation therapy, managing the side effects of radiotherapy, new developments, common cancers, including patients with lung cancer, colorectal cancer, breast cancer, prostate cancer, gynaecological cancer, upper gastrointestinal tract cancer, cancer of the bladder and ureter, and tumours of the central nervous system, chronic leukaemia and myeloma, palliative care of patients with carcinomatosis of unknown primary site, and investigations.

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18

Jolly, Elaine, Andrew Fry, and Afzal Chaudhry, eds. Oncology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199230457.003.0015.

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Chapter 15 covers the basic science and clinical topics relating to oncology which trainees are required to learn as part of their basic training and demonstrate in the MRCP. It covers basic science, genetics in oncology, screening strategies in oncology, diagnostic techniques in oncology, oncological emergencies, breast cancer and lymphoma, prostate cancer, paraneoplastic syndromes, chemotherapy, biological therapy, and targeted therapy, radiotherapy, end of life: the multidisciplinary approach, and symptom control.

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19

Malik, Tariq M. Back Pain: It’s Not Always Arthritis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0029.

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Back pain is prevalent in adults, and most often its cause is nonspecific and benign. Imaging and interventions are not always helpful and they are generally expensive and low yield. However, in about 10% or fewer cases, a specific etiology is found. A patient history, physical examination, and testing are the methods for finding the cause. Back pain from malignancy must also be considered. Prolonged survival from better chemotherapy has increased the incidence of metastases to bone, especially the spine. Common sources of spinal metastases are cancers of the prostate, kidneys, thyroid, breast, and lungs. The primary treatment is to address the malignancy. Pain from spinal tumors can be treated with chemotherapy, radiotherapy, radiofrequency, or vertebral augmentation therapy. The chapter reviews the epidemiology of spinal cancer pain, evaluation of malignant spinal pain, and what the interventional pain physician can offer patients to alleviate their pain.

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