Journal articles on the topic 'Breast Cancer Patients Malaysia'
To see the other types of publications on this topic, follow the link: Breast Cancer Patients Malaysia.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Breast Cancer Patients Malaysia.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Muhamad, Mazanah, Sharan Merriam, and Norhasmilia Suhami. "Why Breast Cancer Patients Seek Traditional Healers." International Journal of Breast Cancer 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/689168.
Full textAbstract:
Traditional healing is a common practice in low and middle income countries such as Malaysia. Eighty percent of Malaysians consult traditional healers or “bomoh” at some time in their life for health-related issues. The purpose of our study was to explore why breast cancer patients visit traditional healers. This is a qualitative study utilizing in-depth interviews with 11 cancer survivors who sought both traditional and Western medicine. The findings revealed the following reasons for which patients seek traditional healers: (1) recommendation from family and friends, (2) sanction from family, (3) perceived benefit and compatibility, (4) healer credibility, and (5) reservation with Western medicine and system delay. These factors work together and are strongly influenced by the Malaysian cultural context. The issue with the Western health system is common in a developing country with limited health facilities.
2
Amini, Farahnaz, Wong Fu Hou, Edmond Ng Siah Chye, Roslina Omar, Shafinaz Mohd Rejab, Izyan Wajiha Mohd Noor, and Baizurah Mohd. Hussain. "MUTATION PROFILE OF BREAST CANCER IN MALAYSIAN PATIENTS." Journal of Health and Translational Medicine 24, no. 1 (March 5, 2021): 37–44. http://dx.doi.org/10.22452/jummec.vol24no1.6.
Full textAbstract:
Background: Breast cancer (BC) is the most common cancer in women globally. In low- and middle-income countries, the use of appropriate breast cancer genetics services for screening and personalized treatments is severely lacking. This review is aimed to assess and summarize the reported mutation profiles of Malaysian BC patients. Methods: A literature search was performed in PubMed and Google Scholar from 2002 to 2019 using a set of keywords and MESH terms. Results: Data from 14 eligible studies are presented here. A total of 28 genes were studied in Malaysian BC patients in which 445 genetic alterations (229 deleterious, 209 variants with unknown clinical significance (VUC), and seven protective variants) have been reported, with 73 being novel (16% novel). The frequency ranged from 0.2% to 76% for VUC and 2.1 to 15% for deleterious variations. Only BRCA1, BRCA2, PALB2, APOBEC3B, and P53 have been associated with BC risk in Malaysian patients. Nine of these studies were conducted using the overlapped source of patients, which may limit the generalizability of the findings to the whole population of Malaysia. Conclusion: Information on the genetic basis of BC in the Malaysian population is scant. Multidisciplinary efforts with appropriate sample selection techniques and study design with multicenter collaboration are needed to address this issue. Out of thirteen high- and moderated-penetrance pathogenic mutations for BC, only five have been linked to Malaysians’ BC susceptibility. The findings from this review is valuable for decision-makers, researchers, and physicians, to enhance the research plans and utility of genetic services for screening and prevention.
3
Shaharudin, Soraya Hanie, Suhaina Sulaiman, Mohd Razif Shahril, Nor Aina Emran, and Sharifah Noor Akmal. "Dietary Changes Among Breast Cancer Patients in Malaysia." Cancer Nursing 36, no. 2 (2013): 131–38. http://dx.doi.org/10.1097/ncc.0b013e31824062d1.
Full text
4
Nair, Viji, Viji Dina Nazri, Angela Lau, Rozita Hashim, Clare Ratnasingham, and Murallitharan Munisamy. "Impact of a Targeted Free Mammography Screening Program for Underprivileged Women in Malaysia." Journal of Global Oncology 4, Supplement 3 (October 2018): 28s. http://dx.doi.org/10.1200/jgo.18.10320.
Full textAbstract:
Purpose Breast cancer remains the most prevalent cancer among Malaysians today. Almost two thirds of patients are diagnosed in the late stages of disease, stage III to IV, with poorer outcomes. In addition, evidence has also revealed that most of patients who present in these late stages are those from poorer socioeconomic backgrounds. Women from underprivileged backgrounds have been found to have poorer health-seeking behavior, especially in terms of screening for cancer. This is for a number of reasons, such as affordability, distance to health centers, and other socioeconomic factors, which have a large impact, as Malaysia only offers opportunistic screening for breast cancer and not for free. A specific program to provide free mammography screening targeted toward underprivileged Malaysian women was planned and implemented with the aim of improving access to screening and increasing the rate of screening among this specific group of women. Methods Funding for the program was obtained from successful negotiation with a large Malaysian life insurance carrier. To ensure geographic equity, screening services were strategically purchased from 15 hospitals that were spread out across Malaysia. We also built partnerships with various nongovernmental organizations working in the social arena servicing underprivileged groups to reach these groups specifically. The nongovernmental organizations co-organized awareness programs and screening days, together with the National Cancer Society Malaysia, with additional incentivization that included subsidizing transport to mammography centers. Results A total of 5,000 underprivileged women from different geographic localities and ethnicities were screened across Malaysia. Of these, 62% received a mammogram for the first time in their lives, whereas 21% received their first repeat mammogram in more than 3 years. Conclusion A targeted screening program that incorporated a multipronged approach strategy was successful at increasing access to breast cancer screening for underprivileged Malaysian women. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . Murallitharan Munisamy Employment: National Cancer Society of Malaysia Stock or Other Ownership: MMPKV Sdn Bhd–operator of Malaysian Primary Care Clinics
5
Lim, Z. Y., N. Rajaram, C. V. Song, R. Kaur, N. A. Mohd Taib, M. Muhamad, W. L. Ong, et al. "Patient-Reported Outcome Measures Among Breast Cancer Survivors in Malaysia: A Comparative Study With Patients From High-Income Countries." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 103s. http://dx.doi.org/10.1200/jgo.18.75100.
Full textAbstract:
Background: Patient-reported outcome measures (PROMs) are essential for identifying how patients perceive the outcomes of their cancer treatment, and is the ultimate success of cancer care. Although a growing number of studies have focused on PROMs in high income countries (HICs), outcomes relevant to patients in developing countries are less understood. Furthermore, the lack of standardization in PROMs makes it difficult to interpret these data for research or quality monitoring. Aim: In this study, we compared the results of PROM measures between patients in Malaysia, a middle income country, and those in HICs, using standard PROMs questionnaires. We also explored the differences in perceived importance of patient reported outcomes within the multiracial Malaysian cohort. Methods: Breast cancer patients (n=1063) were recruited in hospitals serving suburban areas of Malaysia. Of these, 969 patients were eligible for analysis. The surveys were conducted through face-to-face interviews (68%) or were self-administered (30%). An outcome was considered important if it was scored between 7-9 on a 9-point Likert scale. We compared PROMs scores between Malaysian patients and data previously collected from patients in HICs using logistic regression models, adjusting for demographic and clinical characteristics. A two-step cluster analysis was conducted to explore differences in the perceived importance of PROMs between clusters of Malaysian patients. Results: Compared with 1777 patients from HICs, Malaysian patients were less likely to rate overall and recurrence free survival, as well as emotional, cognitive, social and sexual functioning as very important outcomes. Interestingly, more Malaysian women reported that pain (50% vs. 39%), breast symptoms (51% vs. 35%), and major complications (60% vs. 44%) were very important outcomes ( P < 0.001). Compared with young, married Malaysian women, the cluster of older married women (mean age of 57 vs. 52), who were less likely to have received breast reconstructive surgery (8.6% vs. 16.8%), was more likely to rate sexual functioning (32.8% vs. 25.0%, P = 0.036), body image (63.9% vs. 42.4%, P < 0.001), and satisfaction with the breast (50.7% vs. 37.0%, P = 0.011) as very important outcomes. Conclusion: The differences in breast cancer patient needs between and within populations should be considered carefully to better clinician-patient relationship, patient care and satisfaction and assess the outcomes of our cancer care. Future research is needed to find suitable targeted interventions to identify and address the diverse needs of breast cancer patients in low and middle income countries.
6
Ganesh, Sri, Munn-Sann Lye, and Fen Nee Lau. "Quality of Life among Breast Cancer Patients In Malaysia." Asian Pacific Journal of Cancer Prevention 17, no. 4 (June 1, 2016): 1677–84. http://dx.doi.org/10.7314/apjcp.2016.17.4.1677.
Full text
7
Nies, Yong Hui, Farida Islahudin, Wei Wen Chong, Norlia Abdullah, Fuad Ismail, Ros Suzanna Ahmad Bustamam, Yoke Fui Wong, Saladina Jaszle, and Noraida Mohamed Shah. "Treatment decision-making among breast cancer patients in Malaysia." Patient Preference and Adherence Volume 11 (October 2017): 1767–77. http://dx.doi.org/10.2147/ppa.s143611.
Full text
8
Fatimah Sham, Normala Salim, Nor Hafizatul Akma Shohor, Siti Fatimah Zahra Mohd Anuar, Ain Aqiela Azamuddin, and Norziah Aman. "QUALITY OF LIFE AND SOCIAL SUPPORT AMONG BREAST CANCER PATIENTS IN MALAYSIA." Malaysian Journal of Public Health Medicine 22, no. 1 (April 28, 2022): 154–63. http://dx.doi.org/10.37268/mjphm/vol.22/no.1/art.1077.
Full textAbstract:
Cancer incidence and mortality are rapidly growing worldwide, and Breast Cancer is one of the leading causes of death among women in Malaysia. Social support is an important aspect of the Quality of Life (QoL) as it affects the psychological well-being and health of the patients. The aim of this study is to assess the quality of life and relationship of QoL with social support among female patients with diagnosed Breast Cancer. This is a cross-sectional study involving 259 female patients with diagnosed Breast Cancer from the outpatient unit of the National Cancer Institute, Malaysia. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its breast-specific module (QLQ-BR23) measured QoL and social support by using Perceived Social Support (MPSS) questionnaires. The data was analysed using SPSS version 25.0. The result of this study found that women with Breast Cancer in Malaysia had an excellent global quality of life in which they were able to achieve the highest score in their role and physical function. The result also showed a high rate of social support especially supports from family. There was a positive relationship between QoL and social support (rs: 0.25) generally with a p-value less than 0.05. Therefore, effective measures need to be taken and implemented concerning improving the QoL of Breast Cancer patients.
9
Mujar, Noor Mastura Mohd, Maznah Dahlui, and Nur Aishah Taib. "Presentation, Diagnosis, and Treatment Among Patients With Breast Cancer in Malaysia." Journal of Global Oncology 4, Supplement 3 (October 2018): 25s. http://dx.doi.org/10.1200/jgo.18.10280.
Full textAbstract:
Purpose Breast cancer is the most common form of cancer among women in Malaysia. Although there is a scarcity of data on the relation between delays and survival, it is generally accepted that optimum outcomes are dependent on the early detection and adherence to treatment. This study was conducted to evaluate the time intervals and associated factors with delays in presentation, diagnosis, and treatment among patients with breast cancer who attended public hospitals in Malaysia. Methods A retrospective cohort study was conducted in six public hospitals involving all patients with newly diagnosed breast cancer from January 1, 2012, to December 31, 2012. Data were collected through review of medical records and interviews using a structured questionnaire. Presentation delay was defined as time taken from the discovery of symptoms to the first presentation at primary care of more than 3 months. Diagnosis delay was defined as time taken from the first presentation to diagnosis disclosure of more than 1 month, and treatment delay was defined as time taken from diagnosis disclosure to initial treatment of more than 1 month. We used univariable logistic regression and multiple logistic regressions for analysis. A total of 340 patients with breast cancer were included in the study. Median times for presentation, diagnosis, and treatment were 2.4 months, 26 days, and 21 days, respectively. The presentation delay rate was 35%, and the factors associated with it were location (Kelantan: odds ratio [OR], 4.78) and use of complementary and alternative medicine (OR, 1.67). The diagnosis delay rate was 41.8%, and the factors associated with it were symptoms without lump (OR, 1.98), undergoing two or more biopsies (OR, 3.02), and surgical biopsy (OR, 2.56). Meanwhile, the treatment delay rate was 35.3%, and the factors associated with it were location (Johor: OR, 4.95; Kelantan: OR, 6.68; and Sarawak: OR, 3.88) and those diagnosed at other hospitals (OR, 2.18). Results Delays in presentation, diagnosis, and treatment were high among patients with breast cancer who attended public hospitals in Malaysia. Factors that influenced delays were locality, socio-culture, patients, and health systems. Mutual collaboration involving patients and health care sectors and a comprehensive intervention study are suggested to improve the quality of breast cancer care in Malaysia. Conclusion Delays in presentation, diagnosis, and treatment were high among patients with breast cancer who attended public hospitals in Malaysia. Factors that influenced delays were locality, socio-culture, patients, and health systems. Mutual collaboration involving patients and health care sectors and a comprehensive intervention study are suggested to improve the quality of breast cancer care in Malaysia. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . No COIs from the authors.
10
Bustamam, Ros Suzanna Ahmad, Yu Kong Leong, Flora Li Tze Chong, Florence Wong Yoke Fui, Yew-Teik Cheong, and Goh Kenny. "A Retrospective, Observational Study to Determine the Patient and Tumor Characteristics of HER2-Positive Breast Cancer Patients Treated at Five Main Public Cancer Centers in Malaysia." Asian Journal of Oncology 6, no. 01 (January 2020): 10–19. http://dx.doi.org/10.1055/s-0040-1708108.
Full textAbstract:
Abstract Introduction Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer is a high-risk subtype with poor prognosis. The incidence of HER2 expressing tumors is high in Malaysia; however, there is limited information on the characteristics of these tumors. Therefore, we sought to collect the patient and tumor characteristics of HER2+ breast cancer cases at five centers in Malaysia. Patients and Methods A retrospective review was conducted of the data from charts of patients diagnosed with HER2+ breast cancer between January 2014 and December 2015 at Hospital Kuala Lumpur, Institute Kanser Negara, Hospital Pulau Pinang, Hospital Besar Sarawak, and Hospital Likas in Malaysia. Results Of the 1,519 screened patient’ charts, 396 were included for the analysis. The average age of HER2+ breast cancer cases at diagnosis was 51.07 years. A high percentage of cases presented at an advanced stage (38.89 and 12.12% with stage 3 and 4, respectively). About 58.84% of patients were categorized as “high-risk,” with one or more lymph node involvement. Close to half (47.98%) of cases presented with T2 stage tumors, and infiltrating ductal carcinomas were reported in 85.35% of tumors. The most common immunohistochemical subtype was estrogen receptor (ER)+/progesterone receptor (PR)+/HER2+ (47.47%), followed by ER–/PR–/HER2+ (37.12%). Conclusion HER2 overexpressing tumors represent an aggressive subtype in Malaysia with large tumor size, high tumor grade, and lymph node involvement. Early diagnosis and management of these tumors may help improve the survival rates. Future studies should help elucidate the treatment patterns and outcomes in HER2+ breast cancer patients in Malaysia.
11
Mamat, Wan Hasliza Wan, Nikki Jarrett, and Susi Lund. "Diagnostic Interval: Experiences among Women with Breast Cancer in Malaysia." Open Access Macedonian Journal of Medical Sciences 9, T5 (January 2, 2022): 54–59. http://dx.doi.org/10.3889/oamjms.2021.7833.
Full textAbstract:
BACKGROUND: The diagnostic pathway is critical for early breast cancer detection and prognosis improvement. Countries such as the United Kingdom, particularly England, have implemented faster diagnosis standards to ensure that patients receive a definitive diagnosis of cancer or are ruled out within 28 days of referral. However, there is a severe shortage of data on the experiences of breast cancer patients in Malaysia during the diagnostic interval. AIM: This study aimed to explore what happened to the women during the diagnostic phase prior to confirmation of breast cancer. METHODOLOGY: Purposive sampling was applied, and 14 participants were recruited from two government hospitals. The participants took part in in-depth, face-to-face, one-time, and audio-recorded interviews. All the interviews were subsequently transcribed verbatim and analyzed using narrative analysis. RESULTS: The diagnostic interval for the women in this study was 1–3 months from first medical contact till diagnosis. Four themes were identified during the analysis for the diagnostic interval: 1) Women who are suspected of having breast cancer; 2) Women who experience false reassurance; 3) Woman who experience delayed referral; and 4) Women who experience inconclusive investigation results. CONCLUSIONS: This study indicates that early warning signs of breast cancer may prompt doctors to take immediate action. However, unexpected delays may occur as a result of staffing and system issues in the healthcare system. Healthcare professionals should aggressively refer patients with typical symptoms and actively follow-up with patients who present with atypical symptoms in the community. Continuing education for healthcare professionals is necessary to improve diagnostic and referral procedures.
12
Mirabolghasemi, Marva, Noorminshah A. Iahad, and T. Ramayah. "Influential Factors in Breast Cancer Patients' Performance Using Malaysian Social Network Support Groups." International Journal of Healthcare Information Systems and Informatics 14, no. 4 (October 2019): 73–90. http://dx.doi.org/10.4018/ijhisi.2019100105.
Full textAbstract:
Social network communities can serve as a health resource for cancer patients to share and disseminate information. Even so, theory-based research into evaluating cancer patients' performance empirically using social network sites (SNSs) is limited, representing an identifiable knowledge gap. This study proposes a research model that integrates social cognitive theory and task technology fit theory to contribute to the understanding of key factors impacting the performance of breast cancer patients using SNSs. Data were collected via a structured paper-based questionnaire. A total of one hundred seventy-eight (178) participants from six cancer support groups and hospitals in Peninsular Malaysia responded to the administered survey. Survey data were analyzed using the partial least squares (PLS) method while Smart PLS was used to test the hypotheses and to validate the proposed model. Results indicate that outcome expectation, self-efficacy, negative affect, positive affect, social support and task technology fit are significant factors affecting the performance of breast cancer patients vis-à-vis Malaysian social network support groups.
13
Jauhari, A. H. Asmali, N. Bhoo-Pathy, T. Islam, M. Y. Jalaludin, F. M. Moy, and N. A. Taib. "Serum 25(OH) Vitamin D Deficiency and Risk of Breast Cancer in Malaysia: A Case-Control Study." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 23s. http://dx.doi.org/10.1200/jgo.18.64100.
Full textAbstract:
Background: Despite the emerging literature supporting the beneficial role of sufficient vitamin D level and its association with various cancers, current evidence on the vitamin D and the risk of getting breast cancer is still inconsistent. Furthermore, the study between vitamin D status and breast cancer risk among south east Asian women is limited. Aim: We aimed to investigate the association between vitamin D deficiency and the risk of getting breast cancer among Malaysian women. Methods: We conducted a retrospective nested case control study which consisted of Malaysian Breast Cancer Cohort Study (MyBCC) subjects as the cases and UMMC Mammogram Cohort Study subjects as the hospital control. We also used a secondary data from the Cohort Study on Clustering of Lifestyle Risk Factors and understanding its association with stress on health and well-being among school teachers in Malaysia (CLUSTer), as we only included the data from the schools in Kuala Lumpur as the population control. We measured and compared serum 25-hydroxyvitamin D (25(OH)D) between newly diagnosed breast cancer patients (n= 231), female without cancer who came for mammogram checkup (n= 462) and female teachers without cancer from schools in Kuala Lumpur (n=231). Vitamin D deficiency was defined as serum (25(OH)D) < 50 nmol/L. Results: Median serum (25(OH)D) for cases and controls were 42.43 nmol/L and 44.30 nmol/L, respectively. We examined the association between serum (25(OH)D) and breast cancer risk stratified by age < 50 and ≥ 50 years old. The crude ORs for breast cancer risk in cases and controls did not show statistically significant association with serum (25(OH)D) for both age groups ( P = 0.463 and P = 0.650, respectively). After adjustment for age, ethnicity, education level and BMI the ORs (95% CI) for breast cancer risk among both groups were 1.183 (0.591-2.366) ( P = 0.635) and 1.237 (0.801-1.911) ( P = 0.338) respectively for women with serum (25(OH)D) < 50 nmol/L. Conclusion: Our results suggest that there is lack of association between vitamin D deficiency and the risk of getting breast cancer in Malaysian women.
14
Ainaa Almardhiyah, Abd Rashid, Zahali Zunura’in, Venkata Murali Krishna Bhavaraju, Siew Hua Gan, Abdullah Sarimah, Syed Abdullah Sharifah Zahhura, and Jan Mohamed Hamid Jan. "Nutritional Status Influences High-Molecular Weight (HMW) Adiponectin levels in Breast Cancer Patients: Comparison with Healthy Controls." World Nutrition Journal 2, no. 2 (January 4, 2019): 15. http://dx.doi.org/10.25220/wnj.v02.i2.0004.
Full textAbstract:
Introduction: Breast cancer is the leading killer of women in Malaysia. Nutritional status and adiponectin are modifiable risk factors for breast cancer occurrence which can be efficiently targeted. The purpose of this study was to determine the relationship between nutritional status and high molecular weight (HMW) adiponectin levels among breast cancer patients as compared to controls. Methods: This was a case- control study, conducted in Hospital Universiti Sains Malaysia and Universiti Sains Malaysia campus. Newly diagnosed breast cancer cases (n=55) were assigned as cases while healthy controls (n=58) were staff members of HUSM and USM campus. Sociodemographic and reproductive data were obtained with a standard questionnaire while the dietary data was obtained from a validated diet history questionnaire. Anthropometric assessments [weight, height, hip, waist circumference (WC) and body fat composition] were measured while overnight fasting venous blood samples were analysed for lipid profiles, glucose, insulin, high sensitivity C-reactive protein and HMW adiponectin. Results: A significant linear negative relationship exists between WC and HMW adiponectin (β=-0.05; p=0.005) among breast cancer cases. Additionally, HDL cholesterol was positively associated with HMW adiponectin (β=1.83; p=0.010) among the cases. BMI was negatively associated with HMW adiponectin (β=-0.02; p=0.001) among healthy controls. Conclusion: Our findings suggest that WC, BMI and HDL cholesterol had significant relationship with HMW adiponectin. Low levels of HMW adiponectin, low WC and high HDL levels may be protective against breast cancer
15
Hoon, TS, MA Ansari, IL Shuaib, AR Mohd Ariff, I. Khalid, MB L. Mohd Basheer, M. Tun, and Mohd E. Aziz. "MR imaging features and contrast enhancement characteristics in benign and malignant breast lesions." Journal of Institute of Medicine Nepal 34, no. 2 (October 30, 2013): 28–37. http://dx.doi.org/10.3126/jiom.v34i2.9052.
Full textAbstract:
Introduction: Breast cancer is the commonest female malignancy in Malaysia and other countries the world. All races are affected in Malaysia and breast cancer comprised 30.4% of all newly diagnosed cancer cases. A women in Malaysia has a 1 in 19 chances of getting breast cancer in her lifetime. The Age Standardized Rate (ASR) of female breast cancer in Malaysia is 52.8 per 100,000 people and is higher than that in Singapore, Hong Kong and Shanghai, but it is lower than that in Australia and the UK. Out of the 4,337 new cases of female breast cancer cases reported to the National Cancer Registry of Malaysia in 2002, 52.3% were for women less than 50 years old. Genetic risk factors have not been studies thoroughly in Malaysia. Methods: We prospectively studied 55 patients with breast lumps in whom MR imaging was performed. The T1- and T2-weighted, axial STIR, fat-suppression contrast enhanced fast spin echo and two dimensional dynamic enhanced fast spoiled gradient-echo images were obtained. The tumour margins and shape, enhancement pattern and time-signal intensity curves were analysed. Results: A total of 37 patients fulfilled the study criteria with the mean age of 43.46 ±11.99 years (age ranged 21-70). There were 23 benign and 14 malignant lesions. The MR imaging criteria suggestive of malignancy were poorly defined and spiculated margins, irregular shape, heterogeneous and rim enhancement as well as type II and III curves. On the other hand, the criteria for a benign breast lesions were well-defined margin, regular and lobulated shape, none or homogeneous enhancement and type I curve. Only the malignant lesions are characterised by skin, retroareolar, nipple and pectoralis muscle involvement. Conclusion: MR imaging is a valuable complementary breast imaging tool to further evaluate equivocal findings on conventional x-ray mammography. A combination of lesion morphology and enhancement characteristics is useful in distinguishing benign from malignant lesions. DOI: http://dx.doi.org/10.3126/joim.v34i2.9052 Journal of Institute of Medicine August, 2012; 34:2 28-34
16
Mohammed, Ali Haider, Fares Mohammed Saeed Muthanna, Bassam Abdul Rasool Hassan, Mahmathi Karuppannan, and Abdulrasool M. Wayyes. "Impact and Association of Anaemia Severity and Its Treatment With Quality of Life of Breast Cancer Patients in Malaysia." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, no. 2 (December 23, 2022): 62–70. http://dx.doi.org/10.31351/vol31iss2pp62-70.
Full textAbstract:
Anaemia is a crucial issue among cancer patients and need to be treated properly. High incidence of anaemia in patients with cancer have been associated with several physiological manifestations, leading to decreased quality of life (QOL). The current study aimed to assess the severity of anaemia, evaluate the current treatment guideline of anaemia, and to determine the association between the level of anaemia and its treatment on quality of life of breast cancer patients in Malaysia. This prospective study conducted among breast cancer patients in multicancer centers in Malaysia including three follow ups after receiving their chemotherapy. Clinical data were collected from their medical records and at each follow up, they asked to fill up a functional assessment chronic therapy (FACT-An) questionnaire. Descriptive and inferential statistical analysis were done using SPSS. The mean age of participants was 52 ± 11 years old, and out of 120 participants, 32% received anti-anaemic treatments including 87% of them were prescribed with iron supplementation and only 13% received combination of blood transfusion and iron therapy. Surprisingly, none of the participants received erythropoietin stimulating agents (ESAs). Statistical tests also indicated a significant association between anti-anaemic treatments with haemoglobin level and QOL scores. However, this association was insufficient to significantly improve QOL or palliate anaemia severity among participants. This study showed a great evidence that, the current practice of anaemia treatment (iron therapy) among breast cancer patients in Malaysia’s healthcare setting, was not sufficient to palliate anaemia severity or to improve patients’ QOL. There is still a lot of gaps to improve in the management of anaemia among breast cancer patients to show a significant improvement in haemoglobin level. Therefore, respective organisations and oncologists are required to raise awareness about the optimal treatment of anaemia among breast cancer patients, as a result, improve their general wellbeing
17
Kiew, S. J., T. Islam, N. A. Taib, and H. A. Majid. "The Prevalence of Metabolic Syndrome Among Newly Diagnosed Malaysian Breast Cancer Patients." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 120s. http://dx.doi.org/10.1200/jgo.18.46700.
Full textAbstract:
Background: The incidence of breast cancer has increased in South East Asian (SEA) women. Malaysia has the highest obesity rates in SEA. Malaysian Breast Cancer Survivorship Cohort (MyBCC) study is a hospital-based prospective cohort study that aims to study the association between lifestyle factors and overall survival and quality of life of Malaysian breast cancer patients. Metabolic syndrome (MS) is associated with increasing levels of inflammatory cytokines and leptin that can stimulate cell proliferation through various mechanisms, hence indicating both an increased risk of developing breast cancer and a poorer prognosis. However, there is very scarce information available on the presence of MS among the newly diagnosed breast cancer patients. This is an early report of the presence of MS in the MyBCC study. Aim: We aim to evaluate the presence of MS among newly diagnosed breast cancer patients and to determine the association of MS and sociodemographic factors. Methods: 370 newly diagnosed breast cancer patients were interviewed at baseline. The anthropometric data (waist circumference, hip circumference, body weight, body height and body fat percentage) and also blood for lipid profile and glucose profile were collected. The MS status of the patients was defined using a modified International Diabetes Federation worldwide definition; presence of central obesity (waist circumference ≥ 80 cm) and any of two or more of the following criteria: (i) raised triglyceride with ≥ 1.7 mmol/L, (ii) reduced HDL-cholesterol that < 1.3 mmol/L, (iii) diagnosed with hypertension and (iv) diagnosed with diabetes. Results: Among the 370 breast cancer patients, most were aged 51 years and above (258, 69.7%), were Chinese (180, 48.6%), had secondary school education level (168, 45.4%), had less than RM3500 household income (193, 52.2%) and were postmenopausal (250, 67.6%). Most of the patients were obese or overweight (268, 72.4%) and around half of the patients (190, 51.4%) had high body fat percentage. 140 patients had MS (37.8%). MS was significantly higher among patients aged 61 years and above (59, 42.1%) and 51 to 60 years (50, 35.7%) compared with 20 to 50 years of age group (31, 22.1%) ( P < 0.05). The patients with MS were significantly higher among Chinese ethnicity (57, 40.7%), unemployed (95, 70.4%), and postmenopausal (108, 77.1%) ( P < 0.05). Conclusion: The prevalence of MS is high in newly diagnosed Malaysian breast cancer patients. With longer follow-up, further analysis will be done to look at association with outcomes.
18
Junazli, N. I., D. Kamaruddin, S. S. Sabu, Z. Basheer Ahmad, H. S. Mohd Hashim, C. Lim, S. L. Choo, K. Y. Low, and M. Munisamy. "Factors Associated With an Abnormal Mammogram Finding in Women Undergoing Screening in Kuala Lumpur, Malaysia." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 55s. http://dx.doi.org/10.1200/jgo.18.47500.
Full textAbstract:
Background: Breast cancer is the most common cancer among Malaysian women, with a rising incidence from 16.5% in 2006%–17.7% in 2011. One of the key strategies in breast cancer control is early screening; of which mammography is a highly accurate tool, having been shown to reduce the number of mortality rates due to breast cancer up to 30%. However, mammography is often not as widely available in Malaysia; and in many local settings, healthcare providers have to limit screenings to only particular groups such as those with abnormal clinical breast examinations due to limited resources. Knowledge of other predictive factors may assist in further decision-making to prioritize patients for screening mammography in a low-resource setting. Aim: This study aimed to determine such predictive factors for abnormal mammogram findings among women who underwent mammography examination at a center in Kuala Lumpur, Malaysia. Methods: This was a cross-sectional study of women (n = 5491) who underwent a three-dimensional tomosynthesis mammography procedure at the Cancer and Health Screening Clinic, National Cancer Society of Malaysia (NCSM) in Kuala Lumpur, from Jan 2016 until Dec 2017 (2 years). Patients were surveyed on: i) age, ii) ethnicity, iii) family history of breast or any cancers, if any, iv) reproductive history (age of menarche, age of first delivery, age of menopause); and v) history of postmenopausal estrogen and hormone replacement therapy (HRT). Bivariate analysis was conducted by using χ2 tests in determining associations between variables and a multiple logistic regression model built to identify factors which were predictive of an abnormal mammogram finding (BI-RADS 4 & 5). Results: From the bivariate analysis; nulliparous status ( P = 0.02), a family history of breast cancer ( P = 0.04), and a history of postmenopausal hormone replacement therapy (HRT) ( P = 0.01) were determined to significantly associated with an abnormal mammogram finding. There were also significant ethnic differences between women who had abnormal mammogram findings; with Chinese women having highest odds of this (OR:3.22; 95% CI 1.86-5.74). Women within the age group of 45-54 (OR:1.84, 95% CI 1.19-3.12), a family history of breast cancer (OR 2.03, 95% CI 1.31-3.27) or any cancer (OR 1.56, 95% CI 1.06-2.94), age of menopause (OR 2.86; 95% CI 1.43-4.02) and age of first delivery above 30 (OR 1.73, 95% CI 1.26-3.45) were significantly associated with abnormal mammogram findings. Conclusion: Factors which predict abnormal mammogram findings in a Malaysian setting can be used as baseline evidence to formulate criteria which can be used to carry out targeted screening programs or even as cutoff criteria for focusing screening resources in resource-limited settings. This data may be of benefit in aiding healthcare providers in provisioning of services at a macro level as well as for frontline healthcare personnel in helping them profile women who should be focused on to be screened for the disease.
19
Pathy, N. T. Bhoo, Y. C. Kong, S. Subramaniam, P. P. Goh, C. W. Ng, C. H. Yip, and N. Bhoo Pathy. "Patterns of Complementary and Alternative Medicine Use Following a Cancer Diagnosis in Malaysia." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 104s. http://dx.doi.org/10.1200/jgo.18.74300.
Full textAbstract:
Background: Worldwide surveys suggest that the use of CAM is becoming increasingly popular among the general population as well as among cancer patients. Aim: We determined the patterns of complementary and alternative medicine (CAM) use in cancer patients, and the associated factors in a multiethnic Asian setting. Methods: Through the Asean CosTs In ONcology (ACTION) prospective cohort study, 1662 newly diagnosed cancer patients were recruited from 12 public and 2 private hospitals in Malaysia. In the current study, we only included 1328 patients who were alive and completed one-year of follow-up. Using questionnaires and cost diaries, patients' sociodemographic factors and disease related factors were measured at baseline, whereas details on CAM use were measured at 12 months. Results: Median age at cancer diagnosis was 53 years. Patients comprised those with breast cancer (33%), gastrointestinal cancers (27%), hematologic malignancies (22%), female reproductive cancers (6%), respiratory cancers (5%), and other types. At one-year, 175 patients reported using CAM (14%), of which 53 comprised patients reporting inability to make necessary household payments (economic hardship) at initial diagnosis. Most CAM users took food or nutritional supplements (75%), spending between RM150 to RM7500 in a year, followed by traditional local medicine (43%), where expenditures ranged between RM50 to RM20,000. A minority practiced homeopathy, and mind-body practices. Fifty-one patients used more than one type of therapy. In CAM users with economic hardship at baseline, median expenditure on CAM was RM1500, with some spending as much as RM10,000. Compared with other cancer types, patients with hematologic malignancies and women with breast cancer were most likely to use CAM. In a multivariable analysis, baseline factors that were associated with CAM use were economic hardship, higher anxiety scores, having female reproductive cancers, or hematologic malignancies, receipt of surgery, and nonreceipt of radiotherapy. Sex, education status, marital status, health insurance status, cancer stage, and systemic cancer therapy do not appear to be associated with CAM use. Conclusion: While the proportion of patients reporting CAM use following a cancer diagnosis appear low in this study, the finding that patients with initial economic hardship were independently more likely to use CAM, warrants attention.
20
Mohd Shariff, Noorsuzana, Nizuwan Azman, Rohayu Hami, Noor Mastura Mohd Mujar, and Mohammad Farris Iman Leong Bin Abdullah. "Multicentre prospective cohort study of unmet supportive care needs among patients with breast cancer throughout their cancer treatment trajectory in Penang: a PenBCNeeds Study protocol." BMJ Open 11, no. 3 (March 2021): e044746. http://dx.doi.org/10.1136/bmjopen-2020-044746.
Full textAbstract:
IntroductionProper assessment of unmet supportive care needs of patients with breast cancer and its influencing factors at different treatment intervals will improve the rehabilitation of patients with breast cancer. Therefore, this study aims to determine the prevalence of unmet supportive care needs, changes of needs over time and associated factors during the treatment period.Methods and analysisThis multicentre, prospective cohort study will be conducted in three governmental hospitals and one tertiary cancer institute in Penang, Malaysia. Adult women diagnosed with primary or recurrent tumour, node, metastases stage I–IV breast cancer based on pathological biopsy will be eligible for this study. At least 281 samples are required for this study. Participants will undergo follow-up at three time intervals: T1 at breast cancer diagnosis; T2 at 3 months after diagnosis and T3 at 6 months after diagnosis. Patients will complete a set of questionnaires at each time. The primary outcome of this study includes the changes in supportive care needs over three time points, followed by the secondary outcome examining patients’ characteristics, coping behaviours and positive psychological components as they affect changes in unmet supportive care needs over time.Ethics and disseminationThe study has received ethics approval from the Medical Research and Ethics Committee, Ministry of Health Malaysia (NMRR-19-268-45809 IIR) and the Human Research Ethics Committee of Universiti Sains Malaysia (USM/JEPeM/17100443). The results of the prospective study will be submitted for publication in a peer-reviewed journal.
21
Lee, Y. Y., N. A. M. Taib, S. S. Yeoh, C. H. Yip, and N. Bhoo-Pathy. "73P Prognostic factors among ER+ HER2- breast cancer patients in Malaysia." Annals of Oncology 26 (December 2015): ix16. http://dx.doi.org/10.1093/annonc/mdv519.22.
Full text
22
Liang, Seng, Manjit Singh, and Lay-Harn Gam. "The Differential Expression of Aqueous Soluble Proteins in Breast Normal and Cancerous Tissues in Relation to Ethnicity of the Patients; Chinese, Malay and Indian." Disease Markers 28, no. 3 (2010): 149–65. http://dx.doi.org/10.1155/2010/704630.
Full textAbstract:
Female breast cancer is one of the leading causes of female mortality worldwide. In Malaysia, breast cancer is the most commonly diagnosed cancer in women. Of the women in Malaysia, the Chinese have the highest number of breast cancer cases, followed by the Indian and the Malay. The most common type of breast cancer is infiltrating ductal carcinoma (IDC). A proteomic approach was applied in this study to identify changes in the protein profile of cancerous tissues compared with normal tissues from 18 patients; 8 Chinese, 6 Malay and 4 Indian were analysed. Twenty-four differentially expressed hydrophilic proteins were identified. We evaluated the potential of these proteins as biomarkers for infiltrating ductal carcinoma based on their ethnic-specific expressions. Three of the upregulated proteins, calreticulin, 14-3-3 protein zeta and 14-3-3 protein eta, were found to be expressed at a significantly higher level in the cancerous breast tissues when compared with the normal tissues in cases of infiltrating ductal carcinoma. The upregulation in expression was particularly dominant in the Malay cohort.
23
Nair, V., D. Nazri, R. Hashim, A. Lau, and M. Muniasamy. "Bridging Barriers, Building Partners: Success of a Multistakeholder Collaborative Effort in Building and Implementing a Free Mammography Programme for Underprivileged Malaysian Women." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 133s. http://dx.doi.org/10.1200/jgo.18.66700.
Full textAbstract:
Background and context: Research has revealed two large problems in the Malaysian breast cancer control context. First, a large disparity existed in diagnostic stages of Malaysian patients during first presentation; with a large percentage of patients presenting in Stage 3 or 4. Second, patients presenting in later stages of disease were revealed to be of lower socioeconomic backgrounds. Shortcomings are thus thought to exist in the capability of women from lower socioeconomic groups to access breast cancer screening. To address these gaps, the National Cancer Society of Malaysia conceptualized and put together a multistakeholder collaborative project. Aim: The aim of this project was to build, finance and implement a free mammography program for underprivileged Malaysian women. Strategy/Tactics: To ensure geographic equity in provision of this program, 14 individual private hospitals in 10 different states in peninsular Malaysia were negotiated with and agreed to provide the mammogram at highly competitive prices. To address transport and other costs which may have acted as a barrier for patients to attend their screening, transportation costs for groups going for their screening was also subsidized. Additional stakeholders' engaged were nongovernmental organizations (NGOs) especially those working with the economically underprivileged such as religious and other community NGOs. They were roped in as partners to spread the message, identify eligible participants and schedule visits. Some NGOs carried this out as part of their own outreach activities; reserving specific days at the screening centers for themselves. Program/Policy process: The program consisted of a free mammogram provided to Malaysian women above 40 years of age who were determined to be underprivileged; defined for this program as those having a monthly household income below the poverty line (RM5000). If the mammogram was found to be suspicious, a confirmatory breast ultrasound was also performed sans payment. Once conceptualized, the program was successfully pitched by NCSM to ETIQA Insurance, a large Malaysian insurer, who agreed to fund this project as part of their sustainable corporate social responsibility (CSR) initiative. In total, the program funded mammograms for 5000 women over a period of 1 year from July 2017 to July 2018. NCSM advertised the program through various channels; including traditional media, social media, and at various outreach programs and events. Outcomes/What was learned: The program has run for 8 months and has already screened 3550 women nationwide. The multistakeholder collaborative effort has been highly successful at creating awareness on breast cancer screening and providing accurate breast cancer screening for a large number of underprivileged women, some for the first time in their lives.
24
Nik Ab Kadir, Mohd Nasrullah, Najib Majdi Yaacob, Siti Norbayah Yusof, Imi Sairi Ab Hadi, Kamarul Imran Musa, Seoparjoo Azmel Mohd Isa, Balqis Bahtiar, Farzaana Adam, Maya Mazuwin Yahya, and Suhaily Mohd Hairon. "Development of Predictive Models for Survival among Women with Breast Cancer in Malaysia." International Journal of Environmental Research and Public Health 19, no. 22 (November 20, 2022): 15335. http://dx.doi.org/10.3390/ijerph192215335.
Full textAbstract:
Prediction of survival probabilities based on models developed by other countries has shown inconsistent findings among Malaysian patients. This study aimed to develop predictive models for survival among women with breast cancer in Malaysia. A retrospective cohort study was conducted involving patients who were diagnosed between 2012 and 2016 in seven breast cancer centres, where their survival status was followed until 31 December 2021. A total of 13 predictors were selected to model five-year survival probabilities by applying Cox proportional hazards (PH), artificial neural networks (ANN), and decision tree (DT) classification analysis. The random-split dataset strategy was used to develop and measure the models’ performance. Among 1006 patients, the majority were Malay, with ductal carcinoma, hormone-sensitive, HER2-negative, at T2-, N1-stage, without metastasis, received surgery and chemotherapy. The estimated five-year survival rate was 60.5% (95% CI: 57.6, 63.6). For Cox PH, the c-index was 0.82 for model derivation and 0.81 for validation. The model was well-calibrated. The Cox PH model outperformed the DT and ANN models in most performance indices, with the Cox PH model having the highest accuracy of 0.841. The accuracies of the DT and ANN models were 0.811 and 0.821, respectively. The Cox PH model is more useful for survival prediction in this study’s setting.
25
Ahmad, Azura Rozila, Jia Shin Jessica Tan, Arkonam Balasubramaniam Manivannan, and Mohamed Ibrahim Abdul Wahid. "Breast cancer survivorship in an Asian specialist centre from Malaysia: A retrospective analysis." Asian Journal of Medical Sciences 10, no. 6 (October 30, 2019): 22–27. http://dx.doi.org/10.3126/ajms.v10i6.25885.
Full textAbstract:
Background: Real world data (RWD) is increasingly relevant in breast cancer (BCa) as it is the most frequently diagnosed cancer. Developed world has seen improved breast cancer survival, however, RWDon BCa survival in Malaysia is still lacking.
Aims and Objectives: This study aims to determine characteristics and survival of BCa patients from a single institute.
Materials and Methods: Retrospective analysis of 168 BCa patients who were treated with at least one treatment modality in Beacon International Specialist Centre (BISC) from 2008-2012 was conducted. Patient characteristicsand treatments received were analysed descriptively to survival outcome.Vital status was obtained from the National Registry of Birth and Death (NRD) records. Observed survival rates wereestimated by Kaplan-Meier method and difference between groups by log-rank.
Results: Of 143 eligible BCa patients,28 (19.6%) died during the study period. Five-year BCa specific survival rates were 100% for Stage I and II, 79.31% for stage III and 38.89% for Stage IV disease. In the multivariate analysis, higher stage at diagnosis, triple negative breast cancer with metastases and higher grade were associated with worse survival outcomes. The overall 5-year survival rate of BCa patients in BISC from 2008-2012 compares favourably to the survival data of developed countries.
Conclusion: In conclusion, the overall 5-year survival rate of BCa patients in BISC compares favourably to the survival data of developed countries, as well as to other institutions.
26
Abdullah, Nor Aini, Wan Rozita Wan Mahiyuddin, Nor Asiah Muhammad, Zainudin Mohamad Ali, Lailanor Ibrahim, Nor Saleha Ibrahim Tamim, Amal Nasir Mustafa, and Muhammad Amir Kamaluddin. "Survival Rate of Breast Cancer Patients In Malaysia: A Population-based Study." Asian Pacific Journal of Cancer Prevention 14, no. 8 (August 30, 2013): 4591–94. http://dx.doi.org/10.7314/apjcp.2013.14.8.4591.
Full text
27
Choo, S. B., A. Saifulbahri, S. N. Zullkifli, M. L. Fadzil, A. Md Redzuan, N. Abdullah, R. S. Ahmad Bustamam, H. Z. Ahmad, and N. Mohamed Shah. "Adjuvant endocrine therapy side-effects among postmenopausal breast cancer patients in Malaysia." Climacteric 22, no. 2 (December 17, 2018): 175–81. http://dx.doi.org/10.1080/13697137.2018.1540563.
Full text
28
Yeoh, Zi-Yi, Maheswari Jaganathan, Nadia Rajaram, Sudha Rawat, Nurul Ain Tajudeen, Norlia Rahim, Nur Hidayati Zainal, et al. "Feasibility of Patient Navigation to Improve Breast Cancer Care in Malaysia." Journal of Global Oncology, no. 4 (December 2018): 1–13. http://dx.doi.org/10.1200/jgo.17.00229.
Full textAbstract:
Purpose Late stage at presentation and poor adherence to treatment remain major contributors to poor survival in low- and middle-income countries (LMICs). Patient navigation (PN) programs in the United States have led to improvement in diagnostic or treatment timeliness, particularly for women in lower socioeconomic classes or minority groups. To date, studies of PN in Asia have been limited. We aimed to assess the feasibility of PN in a state-run hospital in an LMIC and to report the impact on diagnostic and treatment timeliness for patients in its first year of implementation. Methods We established PN in a dedicated breast clinic of a Malaysian state-run hospital. We compared diagnostic and treatment timeliness between navigated patients (n = 135) and patients diagnosed in the prior year (n = 148), and described factors associated with timeliness. Results Women with PN received timely mammography compared with patients in the prior year (96.4% v 74.4%; P < .001), biopsy (92.5% v 76.1%; P = .003), and communication of news (80.0% v 58.5%; P < .001). PN reduced treatment default rates (4.4% v 11.5%; P = .048). Among navigated patients, late stage at presentation was independently associated with having emotional and language barriers ( P = .01). Finally, the main reason reported for delay, default, or refusal of treatment was the preference for alternative therapy. Conclusion PN is feasible for addressing barriers to cancer care when integrated with a state-run breast clinic of an LMIC. Its implementation resulted in improved diagnostic timeliness and reduced treatment default. Wider adoption of PN could be a key element of cancer control in LMICs.
29
Taib, Nur Aishah, Tania Islam, Ranjit Kaur, and Suhaida Mushtaffa. "Treatment Information and Navigation Program for New Patients With Breast Cancer in Malaysia." Journal of Global Oncology 4, Supplement 3 (October 2018): 45s. http://dx.doi.org/10.1200/jgo.18.10530.
Full textAbstract:
Purpose Advancements in medical treatment with wider treatment options have made breast cancer (BC) care more complex. Short consultation time with physicians, patient fears, and poor coping skills at the time of diagnosis may affect a patient’s decision, causing treatment delays and nonadherence. The main reasons for advanced BC presentation in Malaysia are a delay in making a treatment decision and poor breast health literacy on the disease and its treatment outcomes. To address this gap, we developed an audio-visual tool on multimodal treatments; adverse effects; navigating admission, discharge, and follow-up; and advice on diet and exercise to maintain a healthy lifestyle during the survivorship period in layperson language in Malay, Mandarin, and English. This study aims to assess its effectiveness in improving patient knowledge and satisfaction. Methods A pilot study of 50 patients found that patients needed face-to-face interaction to watch the video. Hence, a breast care nurse–led orientation was developed. A self-administered pre- and postsurvey in 246 patients with newly diagnosed breast cancer in University Malaya Medical Centre was performed to evaluate expectations, satisfactions, and knowledge. We scored the results with the following Likert scale terms: 0 means no knowledge and 4 means a great degree of knowledge. Scoring was done pre- and postintervention. A Wilcoxon matched paired signed rank test was used in the analysis. Results Among 246 patients who received the intervention, 79.3% (n = 197) found that the video met or exceeded their expectations, and 80.2% found the video effective in broadening their perspective on BC treatments. One hundred seventy-one patients (69.2%) rated the video as highly meeting their expectations. There were significant improvements in knowledge of treatment options for BC (mean scores 0.93 v 2.97 for pre- and postintervention; P < .001). Similar findings were found in different types of operations for BC; admission procedures; and information on chemotherapy, radiotherapy, hormone therapy, and alternative medicine. Knowledge scores for healthy diet, physical activity after treatment, and care of the arm were observed ( P < .001). Conclusion Video-based information on treatments and navigating care through a breast care nurse–led service effectively improved patients’ knowledge and satisfaction. This approach can be used to educate patients with cancer in a middle-resource setting. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . No COIs from the authors.
30
Zainuddin, Nur Faizatul Akma, and Nur Adibah Solihin Sulaiman. "Knowledge, Attitude and Practice of Breast Self-Examination among Janitors at Public University Malaysia." Malaysian Journal of Social Sciences and Humanities (MJSSH) 7, no. 12 (December 31, 2022): e001956. http://dx.doi.org/10.47405/mjssh.v7i12.1956.
Full textAbstract:
Breast cancer is the most prevalent form of cancer worldwide including Malaysia. Breast self-examination is recommended as a screening method for early detection of breast cancer. The purpose of this cross-sectional study is to determine the level of knowledge, attitude and practice of breast self-examination among janitors at Health Campus, Universiti Sains Malaysia. A descriptive cross-sectional study was conducted by using simple random sampling, a total of 74 female janitors were recruited into this study. Data were collected using self-administered questionnaire consisting sociodemographic characteristic and level of knowledge, attitude and practice towards breast self-examination. Among participants, 29% (n=22) have good knowledge regarding breast self-examination, 91.9% (n=68) have positive attitude and 51.4% (n=38) have high practice of breast self-examination. There was no significant association between knowledge of breast self-examination and practice of breast self-examination. The study shows attitude of breast self-examination have significant association between practices of breast self-examination. There was no association between socio-demographic characteristic and practice of breast self-examination. This study is crucial because it will provide healthcare professionals the early data, they need to design an effective public awareness campaign that could result in early diagnosis and treatment, which might improve survival among breast cancer patients.
31
Et al., Suraini Mohamad Saini. "Comparison of ultrasound and histopatological findings breast cancer between women aged below and above 40 years." Psychology and Education Journal 58, no. 1 (January 20, 2021): 5713–22. http://dx.doi.org/10.17762/pae.v58i1.2207.
Full textAbstract:
Breast cancer is the most common cancer among females, but breast cancer incidence in young women is low. There are limited studies of breast cancer in this age group in Malaysia, while there are conflicting data regarding these women's prognosis compared to older patients. This study describes the common features presented by breast carcinoma on histopathological and ultrasound findings. Objective: To compare the ultrasound findings and histopathological characteristics of breast cancer for women aged below 40 years and those aged 40 years and above. Methodology: This was a retrospective, cross-sectional study using secondary data, in which the data was collected respectively from patient's clinical histories, radiology findings, and histopathology reports of patients with breast cancer in Hospital Serdang from 1 January 2009 until 31 December 2018. Patients were divided into two age groups (ages below 40, ages 40 and above). Results: 205 patients were included in this study. The most common type of breast carcinoma is invasive ductal carcinoma. Common features are grade II breast cancer cells, DCIS high grade, stage 2 (TNM), tumour size of T2 and lymph node invasion. The majority of tumours are positive with oestrogen receptor, progesterone receptor, and HER2 receptor. Conclusion: Younger age group has a similar feature with the older age group, except they have late stage and progesterone negativity. There is no significant association between age group, ultrasound, histological features, and breast carcinoma receptors.
Keywords: ultrasound breast, histopathological, breast cancer
32
Ho, G. F., N. A. Taib, R. K. Pritam Singh, C. H. Yip, M. M. Abdullah, and T. O. Lim. "What If All Patients with Breast Cancer in Malaysia Have Access to the Best Available Care: How Many Deaths Are Avoidable?" Global Journal of Health Science 9, no. 8 (May 7, 2017): 32. http://dx.doi.org/10.5539/gjhs.v9n8p32.
Full textAbstract:
BACKGROUND: Cancer is a leading cause of death in the world and the fourth leading cause in Malaysia. A widening disparity in cancer burden has emerged between high and low-middle income countries. A similar disparity due to differential access to cancer care between affluent and deprived groups is likely to exist within developing country too. We assess this inequality by estimating the number of deaths due to cancer that would be avoidable if all patients had access to the best available care in Malaysia, a high middle income country.METHODS: The number of avoidable deaths is the difference between the number of deaths estimated by GLOBOCAN12 for Malaysia (which is consistent with published estimates on cancer survival), and the expected number of deaths if all patients with Breast Cancer (BC) had experienced the age-ethnic-stage specific survival outcomes observed in a leading private cancer centre in Malaysia. Data on age-ethnic-stage composition of the general BC population were from local cancer registry and public hospitals providing safety net cancer services.FINDINGS: Of the 2312 excess deaths due to BC, 2048 (88%) were avoidable. Of these avoidable deaths, 1167 (57%) were attributable to late stage presentation while 881 (43%) were due to lack of access to optimal treatment. Sensitivity analyses however show that the 88% avoidable deaths may be as low as 50%, taking into account differences in socio-economic status, over-diagnosis and lack of very long term survival data.INTERPRETATION: The huge number of avoidable deaths highlights the high cancer mortality rate among the deprived and the vast disparity in access to cancer care between the rich and poor within Malaysia, which mirrors the global cancer divide between rich and poor countries.Cancer care system that deliver such disastrous and inequitable outcomes is clearly under-performing. It is in urgent need of reform.
33
Jaganathan, M., N. H. Zainal, N. Rajaram, T. Soo Hwang, and M. Y. Abdul Wahab. "The Feasibility and Performance of the Patient Navigation Programme in Improving Breast Cancer Care in Malaysia." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 95s. http://dx.doi.org/10.1200/jgo.18.59500.
Full textAbstract:
Background: Breast cancer is the most common cancer in Malaysia and it is anticipated that incidence will increase by 49% from 2012 to 2025. Unfortunately, survival remains poor because of late presentation and poor adherence to evidence-based medicine. Barriers to early presentation include inadequate knowledge about the disease, financial issues, negative influence of relatives and perceived poor quality of care and services in state-run hospitals. Poor adherence to treatment is also a common struggle, and is further exacerbated by the use of traditional, alternative healing methods. While patient navigation (PN) programs have been shown to improve breast cancer outcomes in the US, its implementation and performance in low and middle income countries is not well studied. Aim: We sought to determine the impact of a PN program in reducing treatment delays and improving adherence to treatment and patient satisfaction, as well as to evaluate the barriers faced by women seeking breast cancer care in Malaysia. Methods: We established a nurse-led patient navigation center at a secondary government hospital in Klang. This clinical team involved the surgery, pathology, radiology and nursing departments and provided patient-centered care, including patient tracking and call reminder systems, family counseling, health education and decision aids. The community team involved a Patient Navigator Program Coordinator and a Community Navigator. We compared treatment delays and adherence to treatment between navigated patients and patients registered in the year prior to the PN program. We used Student t-tests and Pearson χ2 or Fisher's Exact tests to compare timeliness between navigated patients and patients registered in the year prior. Results: Of the 136 Malaysian women enrolled in the PNP in 2015, 48.9% were diagnosed with advanced disease (stage 3 or 4). Women with advance disease had a lower median monthly household income compared with women with early disease (USD $350 vs $540, P = 0.023). Women with advance disease were also less likely to have personal transportation to the hospital (36.4% vs 56.5%, P = 0.048). Compared with the year before PN, more navigated patients underwent mammography within 7 days of their first visit (96.4% vs 74.4%, P < 0.001) and received their diagnosis within 14 days of their first visit (80.0% vs 58.5%, P < 0.001). The proportion of women who met timeliness to treatment initiation was similar for navigated patients and patients in the year prior. The proportion of defaulters were marginally lesser among navigated patients compared with the year prior (4.4% vs 11.5%, P = 0.048). Conclusion: We found that integrating PN within a breast clinic of a middle income country is feasible, and in the long run, could improve outcomes for breast cancer patients. Long-term follow-up is needed to assess the impact of the PN program on improving treatment completion and survival.
34
Shunnmugam, B., S. Sinnadurai, S. H. Chua, T. Islam, M. H. See, K. Chinna, and N. A. Mohd Taib. "Linguistic and Psychometric Validity of the Malay BREAST-Q in Women Undergoing Breast Cancer Surgery in Malaysia." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 115s. http://dx.doi.org/10.1200/jgo.18.60700.
Full textAbstract:
Background: BREAST-Q is a PROMs used to measure and assess patient satisfaction and quality of life before and after breast cancer surgery. BREAST-Q composed of 5 different modules and each module comprised of multiple scales. Each module has preoperative and postoperative versions to assess the impact of surgery. Four subscales with common items from the 5 modules: “satisfaction with the breast”, psychosocial, sexual and physical well-being were subjected to testing. Two other subscales, “satisfaction with overall outcomes” and “satisfaction with the care” were only validated linguistically. Currently, the BREAST-Q has already been translated into 25 languages. Linguistic and psychometric validation of BREAST-Q has not been performed in Malaysia. Aim: To translate the BREAST-Q into Malay language and perform psychometric validation. Methods: Translation of the English BREAST-Q to Malay language was done based on linguistic validation protocol provided by MAPI Research Trust. Content and face validation were performed to determine contextual accuracy, acceptability and understanding of the items. The finalised Malay BREAST-Q then underwent psychometric testing. Breast cancer patients (n=186) who were planned for breast cancer surgery were conveniently sampled at the breast clinic of UMMC between June 2015 to June 2016. Consented participants completed the questionnaire in the same visit following their diagnosis. Retest was done 2-3 weeks after the first questionnaire administration in 62 patients who were admitted for their surgery. Data were analyzed using SPSS and AMOS software. Results: Content experts (4 breast surgeons) agreed the items in BREAST-Q comprehensively measured the concept of interest and I-CVI for each item was 1.0. Participants agreed the questionnaire was comprehensive and easy to understand. The average time taken to complete the questionnaire was 15.3 minutes. Test–retest analysis showed good reproducibility with intraclass correlation coefficient (ICC) value of 0.71-0.98. Internal consistencies were good for all items in each subscale with Cronbach's alpha values of 0.83-0.95. The highest interitem correlation for each item with at least one other item in the construct ranged from 0.47 to 0.90. The lowest corrected item-total correlation (CITC) values ranged from 0.47 to 0.72. In exploratory factor analysis, the KMO values were excellent in all 4 subscales (0.76, 0.92, 0.91, and 0.86). Single factor was extracted in 3 subscales that explained more than 50% of the variance and 3 factors (breast pain, general pain, and discomfort) were extracted in “physical well-being” subscale that cumulatively explained more than 50% of the variance. Conclusion: The Malay BREAST-Q demonstrated good reliability, content and face validity, and excellent psychometric properties. Hence, we propose the use of the Malay BREAST-Q to measure patient reported outcomes among breast cancer patients in Malaysia undergoing breast cancer surgery.
35
Saiful Bahri, Athirah, Tuan Mazlelaa Tuan Mahmood, Siti Azdiah Abdul-Aziz, Mohd Makmor-Bakry, and Noraida Mohamed Shah. "Use of Adjuvant Endocrine Therapy Among Post-Menopausal Breast Cancer Patients in Malaysia." Patient Preference and Adherence Volume 15 (February 2021): 227–35. http://dx.doi.org/10.2147/ppa.s293029.
Full text
36
Hassan, Mohd Rohaizat, Shamsul Azhar Shah, Hasanain Faisal Ghazi, Noor Mastura Mohd Mujar, Mohd Fadhli Samsuri, and Nizam Baharom. "Anxiety and Depression among Breast Cancer Patients in an Urban Setting in Malaysia." Asian Pacific Journal of Cancer Prevention 16, no. 9 (May 18, 2015): 4031–35. http://dx.doi.org/10.7314/apjcp.2015.16.9.4031.
Full text
37
Lee, Yi Lin, Tania Islam, Mahmoud Danaee, and Nur Aishah Taib. "A longitudinal study of physical activity among Malaysian breast cancer survivors." PLOS ONE 17, no. 11 (November 21, 2022): e0277982. http://dx.doi.org/10.1371/journal.pone.0277982.
Full textAbstract:
Regular physical activity (PA) after a breast cancer diagnosis is associated with reduced mortality and better quality of life. In this prospective cohort study, we aimed to explore the trends of PA among breast cancer survivors over three years and identify factors associated with low PA. Interviews on 133 breast cancer patients were conducted at baseline, one and three years after the diagnosis of breast cancer at University Malaya Medical Centre in Kuala Lumpur. Physical activity was measured by using the Global Physical Activity Questionnaire. PA was categorised as active (≥ 600 MET-min/week) and inactive (<600 MET-min/week). We used the generalised estimating equation method to examine PA levels and factors affecting PA longitudinally. The survivors’ mean age was 56.89 (±10.56) years; half were Chinese (50.4%), and 70.7% were married. At baseline, 48.1% of the patients were active, but the proportion of active patients declined to 39.8% at one year and 35.3% in the third year. The mean total PA decreased significantly from 3503±6838.3 MET-min/week to 1494.0±2679.8 MET-min/week (one year) and 792.5±1364 MET-min/week (three years) (p<0.001). Three years after diagnosis (adjusted odds ratio [AOR]: 1.74, p = 0.021); Malay ethnicity (AOR: 1.86, p = 0.042) and being underweight (AOR: 3.43, p = 0.004) were significantly associated with inactivity. We demonstrated that breast cancer survivors in Malaysia had inadequate PA levels at diagnosis, which decreased over time. Thus, it is vital to communicate about the benefits of PA on cancer outcomes and continue to encourage breast cancer survivors to be physically active throughout the extended survivorship period, especially in the Malay ethnic group and underweight patients.
38
Tan, King Fang, Farzaana Adam, Hasmah Hussin, and Noor Mastura Mohd Mujar. "A comparison of breast cancer survival across different age groups: a multicentric database study in Penang, Malaysia." Epidemiology and Health 43 (May 25, 2021): e2021038. http://dx.doi.org/10.4178/epih.e2021038.
Full textAbstract:
This study compared breast cancer survival and the prognostic factors across different age groups of women in Penang, Malaysia. Data on 2,166 women with breast cancer who had been diagnosed between 2010 and 2014 were extracted from the Penang Breast Cancer Registry and stratified into 3 age groups: young (< 40 years old), middle-aged (40-59 years old), and elderly (≥ 60 years). The overall and relative survival rates were calculated using the life table method, median survival time was calculated using the Kaplan-Meier method, and comparisons between groups were conducted using the log-rank test. Prognostic factors were analyzed using a Cox proportional hazards model. The 5-year overall and breast cancer-specific survival rates for women with breast cancer in Penang were 72.9% and 75.2%, with a mean survival time of 92.5 months and 95.1 months, respectively. The 5-year breast cancer-specific survival rates for young, middle-aged, and elderly women were 74.9%, 77.8%, and 71.4%, respectively, with a mean survival time of 95.7 months, 97.5 months, and 91.2 months. There was a significant difference in breast cancer survival between age groups, with elderly women showing the lowest survival rate, followed by young and middle-aged women. Disease stage was the most prominent prognostic factor for all age groups. Survival rates and prognostic factors differed according to age group. Treatment planning for breast cancer patients should be age-specific to promote better cancer care and survival.
39
Hasbullah, Harissa Husainy, Anita Bustamam, Tho Lye Munn, and Vincent Phua. "Assessment of Survival and Cardiotoxicity of Adjuvant Trastuzumab among HER2 Breast Cancer Patients in an Oncology Centre in Malaysia." Journal of Clinical and Health Sciences 3, no. 1 (June 30, 2018): 33. http://dx.doi.org/10.24191/jchs.v3i1.6156.
Full textAbstract:
Introduction: Adjuvant trastuzumab has been used in human epidermal growth factor-2 (HER2) breast cancer to improve survival but with concern of cardiotoxicity. Our study is the first to review efficacy and toxicity of adjuvant trastuzumab in Malaysia. Methods: This is a retrospective cohort study on HER2 non metastatic breast cancer patients in University Malaya Medical Centre diagnosed between October 2006 and May 2011. Two cohorts were created based on whether or not they received adjuvant trastuzumab. Disease free survival (DFS) and overall survival (OS) for both groups were estimated using Kaplan Meier method and compared using Log rank test. Cox proportional hazards regression models analysed for potential covariates of age, tumour size and grade, node and estrogen receptor (ER) status. Trastuzumab cardiotoxicity was defined as left ventricular systolic dysfunction or heart failure with or without symptoms and graded using Common Terminology Criteria for Adverse Events (CTCAE 4.0). Results: 170 HER2 non metastatic breast cancer patients were identified. Thirty-three received trastuzumab and 136 did not. Median age was 53.4 ± 10.3 years old. Significantly more ER negative patients received trastuzumab. Four years DFS in ‘trastuzumab’ versus ‘no trastuzumab’ cohort was 90.9% vs 74.5% (p = 0.027). Four years OS was 91% vs 84.7% (p = 0.30) respectively. Majority tolerated trastuzumab with no toxicity. Five patients (15.2%) experienced cardiotoxicity (all grade I).Conclusions: Adjuvant trastuzumab significantly improved DFS in HER2 breast cancer. Treatment was well tolerated. With this we propose the justification for adjuvant trastuzumab in HER2 breast cancer in our population.
40
Farid, F. Mohd. "Makna Mobile Mammography Screening Unit." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 182s. http://dx.doi.org/10.1200/jgo.18.61800.
Full textAbstract:
Amount allocated in 2017 for this initiative RM 754,892.00 (US$ 195,353 or CHF 187,509.16) Background and context: Urbanization and its discontent have seen more urban poor in need of immediate medical intervention. Only a small percentage of women ever performed mammogram due to medical screening cost and poor knowledge pertaining to mammography screening for breast cancer. A massive health education campaign through multiple methods and agencies is necessary to upend this deep-seated perception. Aim: MAKNA's mobile mammography screening unit aims to improve lifesaving chances of people afflicted by cancer through early detection of presymptomatic cancer, using approved and fully equipped vehicle with the latest technology available. Focusing in early detection Garnering resources inter alia to help the financially-challenged cancer patients Many cases that come to MAKNA come in the late stages where help of a cure is usually less than 30% Enhancing knowledge and awareness among general public Economic-wise: cheaper to screen for diseases compared with treating patient Reducing death rate from breast cancer by conduct and deliver nationwide campaign all over Malaysia from districts to cities, rural to urban dwellings Strategy: Equipment overall specs Breast screenings with mammography using full fledge digital unit (GE SENOGRAPHE 2000D) Primary objectives: To conduct mammograms and clinical breast examinations (CBE) to public. To conduct general screening to public. Secondary objectives: To conduct cancer awareness and screening program to public. To educate staffs on early detection of cancer. To raise fund for financially challenged cancer patients via MAKNA various fundraising projects Key messages: Early detection saves lives - know the early warning signs and get screened. Care for yourself and others -help us to help the financially challenged cancer patient. (Cancer treatment is very expensive.) Get involved! -Participate in our activities Further targeted communities: Rural interior villages across Malaysia Costs and returns: A. Total 2007-2017: Total costs: RM 5,787,634 (US$ 1,497,398 or CHF 1,437,713) (RM 2,499,500 for fixed assets + RM 3,288,134 for services) Total ROI: Total screenings: 204 locations Results (by case): Normal: 20,027 Benign: 2434 Abnormal/referred: 383 Cancer diagnoses: 23 B. Year of 2017´s impacts: Costs: RM 753,109 (US$ 194,878 or CHF 187,083) ROI: 6378 screenings: 47 locations Result (by case) Normal: 5329 Benign: 956 Abnormal/referred: 93 Cancer diagnoses: 7 What was learned: Majority of cancers are the result of unhealthy lifestyle rather than inherited genetic faults. Breast cancer rate by ethnic: highest in Chinese > Malay > Indian > others. Early stage of breast cancer most detected. Patient navigation program to improve follow-up with positive cases. Overall, this is a scalable solution. Specifically in good prospect to operate in Borneo, East Malaysia with 2 more units.
41
Zulkeflee, Hani Ajrina, Tuan Salwani Tuan Ismail, Tengku Ahmad Damitri Al-Astani Tengku Din, Maya Mazuwin Yahya, and Wan Faiziah Wan Abdul Rahman. "Association of Serum Vitamin D Level and Vitamin D Receptor Expression among Newly Diagnosed Breast Cancer." Sains Malaysiana 50, no. 11 (November 30, 2021): 3321–32. http://dx.doi.org/10.17576/jsm-2021-5011-16.
Full textAbstract:
There is a mushrooming interest in the anti-carcinogenic property of vitamin D. However, many researches reported a conflicting result in the association of vitamin D levels to certain types of cancer. This study was designed to assess the association between vitamin D and vitamin D receptor (VDR) expression with breast cancer. This case-control study, carried out at Hospital Universiti Sains Malaysia, Kelantan, involved 69 newly diagnosed breast cancer patients and 73 healthy volunteers. Serum 25(OH)D was taken and compared between 2 groups. VDR expression in patients’ breast tissue samples was determined by immunohistochemical staining method using anti-VDR antibody. 85.5% of breast cancer patients and 97.3% of healthy control were vitamin D insufficient with a mean (SD) of 13.36 (6.96) ng/mL and 13.05 (3.71) ng/mL, respectively, and the difference was not statistically significant. VDR expression showed cytoplasmic positivity in 75.4% of breast cancer tissue, followed by both cytoplasmic and nuclear positivity in 21.5% and complete absence in 3%. There was no significant association between VDR expression and hormone receptor status. In conclusion, there was a high prevalence of vitamin D deficiency among breast cancer and healthy volunteers in our study. There was no significant association between breast cancer and vitamin D. The VDR expression in breast cancer cells showed high cytoplasmic localization.
42
Hanin, F. K., L. Sit Wai, J. Sabirin, W. P. Sharifa Ezat, and D. Maznah. "Trastuzumab As an Adjuvant Therapy for Early Breast Cancer: Economic Evaluation From a Malaysian Perspective." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 72s. http://dx.doi.org/10.1200/jgo.18.12800.
Full textAbstract:
Background: In Malaysia, breast cancer is the most common cancer in females and also the first most common cancer among population regardless of gender. The percentage of breast cancer detected at stage I and II was 61%, another 27% with locally advanced cancer and 11% with late stage metastatic cancer. From the total, 28% are human epidermal growth factor receptor 2 (HER2) positive and access to targeted therapy (trastuzumab) was very limited; only 19% of eligible patients could be treated. Aim: To determine the incremental cost-effectiveness ratio (ICER) between chemotherapy plus trastuzumab and chemotherapy alone as adjuvant treatment of early breast cancer from Malaysian perspective. Methods: A Markov cohort simulation was developed using Microsoft Excel Workbook 2007 to estimate the cost-utility of adjuvant trastuzumab compared with chemotherapy alone for treatment of early breast cancer with HER2 positive status. Two adjuvant treatment strategies were evaluated: 1) chemotherapy plus trastuzumab and 2) chemotherapy alone as adjuvant treatment. This Markov model was projected to lifetime horizon. All costs and outcomes were discounted at 3% and the cost-effectiveness result was expressed in ICER. One-way sensitivity analysis was performed to address the uncertainty. Results: The base case analysis indicated that 1-year adjuvant trastuzumab treatment generates a deterministic ICER of RM 83,544.59 per QALY gained. Over the lifetime, there is a marginal cost increase of RM 85,659.10 and a marginal benefit of 1.025 QALYs per patient when trastuzumab is added to standard chemotherapy compared with no trastuzumab strategy. Based on one-way sensitivity analysis, these components have shown to be a sensitive parameter for ICER determination: discount rate, disease-free state utility, route of trastuzumab administration and cost of trastuzumab. Conclusion: Addition of 1-year treatment with trastuzumab on top of standard adjuvant chemotherapy is considered as a cost-effective strategy for early breast cancer with HER2 positive, yielding an ICER of RM 83,544.59 per QALY gained, which is within the suggested value of cost-effectiveness threshold by WHO (1-3 times GDP per capita). However, if suggested threshold for Malaysia is taken into consideration, this treatment may not be a cost-effective strategy.
43
Wen, Wei Xiong, Jamie Allen, Kah Nyin Lai, Shivaani Mariapun, Siti Norhidayu Hasan, Pei Sze Ng, Daphne Shin-Chi Lee, et al. "Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia." Journal of Medical Genetics 55, no. 2 (October 9, 2017): 97–103. http://dx.doi.org/10.1136/jmedgenet-2017-104947.
Full textAbstract:
BackgroundGenetic testing for BRCA1 and BRCA2 is offered typically to selected women based on age of onset and family history of cancer. However, current internationally accepted genetic testing referral guidelines are built mostly on data from cancer genetics clinics in women of European descent. To evaluate the appropriateness of such guidelines in Asians, we have determined the prevalence of germ line variants in an unselected cohort of Asian patients with breast cancer and healthy controls.MethodsGerm line DNA from a hospital-based study of 2575 unselected patients with breast cancer and 2809 healthy controls were subjected to amplicon-based targeted sequencing of exonic and proximal splice site junction regions of BRCA1 and BRCA2 using the Fluidigm Access Array system, with sequencing conducted on a Illumina HiSeq2500 platform. Variant calling was performed with GATK UnifiedGenotyper and were validated by Sanger sequencing.ResultsFifty-five (2.1%) BRCA1 and 66 (2.6%) BRCA2 deleterious mutations were identified among patients with breast cancer and five (0.18%) BRCA1 and six (0.21%) BRCA2 mutations among controls. One thousand one hundred and eighty-six (46%) patients and 97 (80%) carriers fulfilled the National Comprehensive Cancer Network guidelines for genetic testing.ConclusionFive per cent of unselected Asian patients with breast cancer carry deleterious variants in BRCA1 or BRCA2. While current referral guidelines identified the majority of carriers, one in two patients would be referred for genetic services. Given that such services are largely unavailable in majority of low-resource settings in Asia, our study highlights the need for more efficient guidelines to identify at-risk individuals in Asia.
44
Hanis, Tengku Muhammad, Najib Majdi Yaacob, Suhaily Mohd Hairon, and Sarimah Abdullah. "Net survival differences of breast cancer between stages at diagnosis and age groups in the east coast region of West Malaysia: a retrospective cohort study." BMJ Open 11, no. 5 (May 2021): e043642. http://dx.doi.org/10.1136/bmjopen-2020-043642.
Full textAbstract:
ObjectiveEstimation of the net survival of breast cancer helps in assessing breast cancer burden at a population level. Thus, this study aims to estimate the net survival of breast cancer at different cancer staging and age at diagnosis in the east coast region of West Malaysia.SettingKelantan, Malaysia.ParticipantsAll breast cancer cases diagnosed in 2007 and 2011 identified from Kelantan Cancer Registry.DesignThis retrospective cohort study used a relative survival approach to estimate the net survival of patients with breast cancer. Thus, two data were needed; breast cancer data from Kelantan Cancer Registry and general population mortality data for Kelantan population.Primary and secondary outcome measuresNet survival according to stage and age group at diagnosis at 1, 3 and 5 years following diagnosis.ResultsThe highest net survival was observed among stage I and II breast cancer cases, while the lowest net survival was observed among stage IV breast cancer cases. In term of age at diagnosis, breast cancer cases aged 65 and older had the best net survival compared with the other age groups.ConclusionThe age at diagnosis had a minimal impact on the net survival compared with the stage at diagnosis. The finding of this study is applicable to other populations with similar breast cancer profile.
45
Ganggayah, M. D., N. A. Taib, T. Islam, and S. K. Dhillon. "Application of Database and Data Science Techniques in the Malaysian Breast Cancer Survivorship Cohort STUDY." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 110s. http://dx.doi.org/10.1200/jgo.18.78500.
Full textAbstract:
Background: Breast cancer is one of the leading cause of mortality among women worldwide. The Breast Cancer Resource Centre (BCRC) of University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia, started the Malaysian Breast Cancer Survivorship Cohort (MyBCC) study in 2012. Aim: As a further enhancement of the research, the MyBCC database has been developed to conduct the survey in a convenient way, which aims to predict the factors influencing different survival rate among patients from multiethnic origin using data science techniques. Methods: The database comprised of life style related data of the patients including demographic factors, information on other illness, clinical factors, quality of life, psychosocial support, physical activity, work related questions, depression score, family background, type of medication consumed and financial status of the patients. This paper presents an approach to build an automated workflow using the MySQL database management system and PHP, integrated with R and HTML for web display. Results: A relational database comprising 816 breast cancer patients' data were developed for the MyBCC cohort study. This database serves as the backend for the MyBCC application where researchers can register new patients' records, update and view the information of recruited patients by using the system in a more commodious environment than before. Besides, the MyBCC database has been integrated with R programming tool by deploying the RMySQL package to perform audits. A few important analysis using plotly package, leveraging the integration of R with database are presented. Conclusion: In this paper, the development of the MyBCC database is presented, with the aim to automate the manual process of data entry, storage and analysis for performing audits for the breast cancer cohort study. The integration of database with R for automated analysis of data are also shown using examples of predictions that can be generated using functions in R. This fully automated workflow reduces the workload and time taken in performing manual predictions using data sources stored in flat files.
46
Yusoff, Jamilah, and Aniza Ismail. "OUT OF POCKETS SPENDING AMONG BREAST CANCER WOMEN RECEIVING OUT-PATIENT TREATMENT IN A TERTIARY TEACHING HOSPITAL IN KUALA LUMPUR MALAYSIA." Malaysian Journal of Public Health Medicine 21, no. 3 (December 28, 2021): 240–49. http://dx.doi.org/10.37268/mjphm/vol.21/no.3/art.1107.
Full textAbstract:
There is lack of information about the estimates of out-of-pocket (OOP) spending among women diagnosed with breast cancer and effects on their family’s financial situation in Malaysia. This study is to determine estimates of out-of-pocket spending among women with breast cancer in HCTM and identify factors that significantly associated with high OOP spending. This cross-sectional study assessed out of pockets spending among breast cancer women in HCTM for breast cancer as out-patient. Sampling unit is a woman who has been diagnosed breast cancer and receiving treatment and follows up in HCTM. A 189 breast cancer women were identified for a 6 months period between July to December 2017. Only those patients who received at least 6 months treatment in HCTM were recruited. Out of pocket spending for treatments for adjuvant therapy and follow up, consultations with other practitioners, care taker fee, equipment and traditional/complementary treatment were collected by face-to-face interview using structured questionnaires. The dependent variable was OOP, analyzed using SSPS v23 for descriptive analysis and both univariate and multivariate analysis.173 out of 186 women were recruited and only 172 were considered for cost calculation (participation rate, 93.0 %) in this study. Total out of pocket spending for breast cancer treatment in 2017 was RM 1,037,446.23 with women’s total means out of pocket spending was RM6031.66 (SD =/- 495.58). The highest percentage of cost component contributed by cost of adjuvant therapy, RM334,056.00 (30.2%) followed by traditional/complementary medicine, RM268,278.00 (24.3%), other expenses/private hospital, RM224,887.00 (20.4%), transportation RM 79,772.52 (7.2%), chemotherapy RM67,300.00 (6.1%), dressing RM54,850.00 (5.0%), equipment/prosthesis RM50,550.00 (4.6%) and care taker cost RM24,661.43 (2.2%). Out of pockets costs from breast cancer in HCTM for 2017 are a burden for women and their family. Financial support provides assistance to the out-of-pocket spending in breast cancer treatment and is able to reduce the financial burden among patients and families.
47
Edib, Zobaida, and Verasingam Kumarasamy. "Quality of Life among Female Breast Cancer Patients in a University Hospital in Malaysia." British Journal of Medicine and Medical Research 6, no. 5 (January 10, 2015): 453–62. http://dx.doi.org/10.9734/bjmmr/2015/15065.
Full text
48
Chua, M., V. Silvathorai, M. Muniasamy, H. S. Mohd Hashim, C. Lim, N. I. Binti Junazli, S. L. Choo, and K. Y. Low. "Experience and Impact of a Locally-Based Peer, Volunteer Cancer Support Programme in Hospital Melaka, Melaka Malaysia." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 113s. http://dx.doi.org/10.1200/jgo.18.47300.
Full textAbstract:
Background: Melaka is a small southern state in Peninsular Malaysia. On average, the state has an annual incidence of 200 odd breast cancer patients, largely treated out of its public, subsidized, single tertiary treatment center of Hospital Melaka. Hospital Melaka is an 800-bedded hospital with multiple specialties including surgery and radiology. Though the hospital does not have a dedicated oncology department, cancer treatment is carried out via phone consultations and visiting oncologists as well as a team of on-site nursing staff who are trained to initiate and monitor treatment. Feedback from Hospital Melaka staff highlighted that there was a drop-out rate of about 30% of patients from the treatment journey. Qualitative interviews with different stakeholders including patient revealed that the drop-out may be driven by factors such as: i) fear of surgery, ii) fear of chemotherapy, iii) fear of disfigurement, iv) loss of spouse v) emotional distress and shock; and vi) delay in waiting times for different levels of diagnostics and treatment. Aim: The aim of the initiative was to reduce the rate of patients who defaulted out from the cancer treatment journey via a three-pronged approach: a) improving understanding about cancer and treatment by patients and family members; b) integrating peer-support into the clinical treatment pathway at the hospital and reduction of waiting times; and c) maintaining a continuous interaction with the patient throughout the treatment journey. Methods: The inception and deployment of a locally-based peer, volunteer support program for breast cancer patients and families as part of the formal cancer treatment process in Hospital Melaka. Volunteers were consisted of a trained mix of cancer survivors, current and retired healthcare practitioners and provided information pertaining to treatment and care aspects of breast cancer as well as emotional support and follow-up of patients via phone or in person to ensure compliance to treatment. In this study, we engaged with various stakeholders including hospital management and clinicians. Then, support group's services were formalized into the care pathway for all patients with breast cancer; with both volunteers able to send and receive patient referrals. Results: Statistically significant reductions in patient delays in decision-making to seek treatment as well as a significant decrease of 12.5% in the number of defaulters. Conclusion: A support program built with support from all stakeholders and run by volunteers and embedded within the formal care process acts as a catalyst to enhance both service delivery as well as keeping patients engaged on the cancer care journey.
49
Jamaluddin, Norrina, Izzuna Mudla Mohamed Ghazali, and Junainah Sabirin. "PP585 A New Hope For Breast Cancer Survivors: Early Assessment Of A Breast Cancer Vaccine." International Journal of Technology Assessment in Health Care 36, S1 (December 2020): 43–44. http://dx.doi.org/10.1017/s0266462320002044.
Full textAbstract:
IntroductionBreast cancer is the most frequent cancer among women globally, impacting 2.1 million women each year, causing the greatest number of cancer-related deaths among women. In Malaysia, the new cases of breast cancer comprised of 32.7 percent of all new cancer cases in women as reported by The International Agency for Research on Cancer (IARC). The recurrence rate was about 16.4 percent post-mastectomy. This early assessment is to evaluate the effectiveness and safety of a breast cancer vaccine.MethodsA systematic review was conducted. Searches were done through PubMed, Medline and ClinicalTrial.gov. The articles were selected based on inclusion and exclusion criteria and appraised using Critical Appraisal Skills Programme (CASP) checklist. More than twenty cancer vaccines under development were identified.ResultsThe most advanced breast cancer vaccine is Nelipepimut-S (NPS). In a Phase 2b clinical trial, improvement disease-free survival (DFS) in the NPS group was 89.8 percent. The DFS rate in the NPS group was 92.6 percent for triple negative patients. Median DFS in the NPS group [hazard ratio (HR): 0.26 (95% confidence interval, Cl: 0.08–0.81)] showed a significant difference. A projection study showed the cost-effectiveness will be 90 percent success if the cost less than USD1,000 per patient. No safety issues were reported.ConclusionsEarly assessment showed potential benefit in patient with triple-negative breast cancer (TNBC). However, further research is required to ensure its efficacy, safety, and cost-effectiveness.
50
Schliemann, Désirée, Wilfred Mok Kok Hoe, Devi Mohan, Pascale Allotey, Daniel D. Reidpath, Min Min Tan, Nur Aishah Mohd Taib, Michael Donnelly, and Tin Tin Su. "Challenges and opportunities for breast cancer early detection among rural dwelling women in Segamat District, Malaysia: A qualitative study." PLOS ONE 17, no. 5 (May 20, 2022): e0267308. http://dx.doi.org/10.1371/journal.pone.0267308.
Full textAbstract:
Introduction Breast cancer patients in low- and middle-income countries often present at an advanced stage. This qualitative study elicited views regarding the challenges and opportunities for breast cancer screening and early detection among women in a low-income semi-rural community in Segamat district, Malaysia. Methods Individual semi-structured interviews with 22 people (health professionals, cancer survivors, community volunteers and member from a non-governmental organization) and four focus group discussions (n = 22 participants) with women from a local community were conducted. All participants were purposively sampled and female residents registered with the South East Asia Community Observatory aged ≥40 years were eligible to participate in the focus group discussions. Data were transcribed verbatim and analyzed using thematic analysis. Results The thematic analysis illuminated barriers, challenges and opportunities across six domains: (i) personal experiences and barriers to help-seeking as well as financial and travel access barriers; (ii) primary care challenges (related to delivering clinical breast examination and teaching breast-self-examination); (iii) secondary care challenges (related to mammogram services); (iv) disconnection between secondary and primary care breast cancer screening pathways; and (v) opportunities to improve breast cancer early detection relating to community civil service society activities (i.e. awareness raising, support groups, addressing stigma/embarrassment and encouraging husbands to support women) and vi) links between public healthcare personnel and community (i.e. improving breast self-examination education, clinical breast examination provision and subsidised mammograms). Conclusion The results point to a variety of reasons for low uptake and, therefore, to the complex nature of improving breast cancer screening and early detection. There is a need to adopt a systems approach to address this complexity and to take account of the socio-cultural context of communities in order, in turn, to strengthen cancer control policy and practices in Malaysia.